1851
Pathway
Thioredoxin Pathway
In this pathway diagram, clicking on the protein class named "a reduced thioredoxin" will display a page showing two instances of this class named reduced thioredoxin 2 and thioredoxin 1. As shown in the gene-reaction schematic on this page, these proteins are the products of genes trxC and trxA, respectively. Clicking on either of the instance names (or on their gene or protein symbols in the gene-reaction schematic) will display a page showing some structural and functional properties of the respective protein.
Again in the pathway diagram, clicking on the protein class named "an oxidized thioredoxin" will display a page showing two instances of this class named oxidized thioredoxin and oxidized thioredoxin 2. Note that in the gene-reaction schematic shown on this page the reduced thioredoxins are considered to be the direct gene products and their oxidized forms are shown separately as modified forms of the gene products.
In E. coli TrxA is a more well studied thiol-disulfide oxidoreductase than TrxC (Trx2). TrxC was identified later as a novel thioredoxin that forms a subfamily of the TrxA protein family. The gene encoding TrxC is under control of the transcriptional regulator OxyR which responds to oxidative stress, although the biological role of TrxC remains to be fully elucidated. (EcoCyc)
Metabolic
PW002082
Center
PathwayVisualizationContext2369
1501
1401
#000099
PathwayVisualization1835
1851
Thioredoxin Pathway
In this pathway diagram, clicking on the protein class named "a reduced thioredoxin" will display a page showing two instances of this class named reduced thioredoxin 2 and thioredoxin 1. As shown in the gene-reaction schematic on this page, these proteins are the products of genes trxC and trxA, respectively. Clicking on either of the instance names (or on their gene or protein symbols in the gene-reaction schematic) will display a page showing some structural and functional properties of the respective protein.
Again in the pathway diagram, clicking on the protein class named "an oxidized thioredoxin" will display a page showing two instances of this class named oxidized thioredoxin and oxidized thioredoxin 2. Note that in the gene-reaction schematic shown on this page the reduced thioredoxins are considered to be the direct gene products and their oxidized forms are shown separately as modified forms of the gene products.
In E. coli TrxA is a more well studied thiol-disulfide oxidoreductase than TrxC (Trx2). TrxC was identified later as a novel thioredoxin that forms a subfamily of the TrxA protein family. The gene encoding TrxC is under control of the transcriptional regulator OxyR which responds to oxidative stress, although the biological role of TrxC remains to be fully elucidated. (EcoCyc)
Metabolic
3
3892
9724776
Debarbieux L, Beckwith J: The reductive enzyme thioredoxin 1 acts as an oxidant when it is exported to the Escherichia coli periplasm. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10751-6.
1851
Pathway
1
Cell
CL:0000000
4
Cardiomyocyte
CL:0000746
5
Hepatocyte
CL:0000182
1
Homo sapiens
9606
Eukaryote
Human
12
Mus musculus
10090
Eukaryote
Mouse
3
Escherichia coli
562
Prokaryote
24
Solanum lycopersicum
4081
Eukaryote
Tomato
18
Saccharomyces cerevisiae
4932
Eukaryote
Yeast
6
Caenorhabditis elegans
6239
Eukaryote
Roundworm
4
Arabidopsis thaliana
3702
Eukaryote
Thale cress
23
Pseudomonas aeruginosa
287
Prokaryote
17
Rattus norvegicus
10116
Eukaryote
Rat
5
Bos taurus
9913
Eukaryote
Cattle
10
Drosophila melanogaster
7227
Eukaryote
Fruit fly
2
Bacteria
2
Prokaryote
Bacteria
21
Xenopus laevis
8355
Eukaryote
African clawed frog
25
Escherichia coli (strain K12)
83333
Prokaryote
60
Nitzschia sp.
0001
Eukaryote
Nitzschia4
5
Cytoplasm
GO:0005737
2
Mitochondrion
GO:0005739
7
Endoplasmic Reticulum Membrane
GO:0005789
4
Peroxisome
GO:0005777
13
Endoplasmic Reticulum
GO:0005783
1
Cytosol
GO:0005829
10
Cell Membrane
GO:0005886
19
sarcoplasmic reticulum
GO:0016529
35
Chloroplast
GO:0009507
3
Mitochondrial Matrix
GO:0005759
36
Membrane
GO:0016020
11
Extracellular Space
GO:0005615
12
Mitochondrial Inner Membrane
GO:0005743
14
Mitochondrial Outer Membrane
GO:0005741
24
Mitochondrial Intermembrane Space
GO:0005758
31
Periplasmic Space
GO:0005620
53
Endoplasmic Reticulum Body
GO:0010168
34
Plant-Type Vacuole
GO:0000325
32
Inner Membrane
GO:0070258
1
Liver
BTO:0000759
72
9
5
cardiocyte
BTO:0001539
28
Stomach
BTO:0001307
155
26
8
Blood Vessel
BTO:0001102
74
11
8
5
1
1
PW_BS000008
3
2
1
1
PW_BS000003
10
1
7
1
1
PW_BS000010
5
4
1
1
PW_BS000005
18
13
1
1
PW_BS000018
2
1
1
1
PW_BS000002
29
1
1
1
PW_BS000029
49
7
1
1
PW_BS000049
31
1
5
1
1
PW_BS000031
14
10
1
PW_BS000014
111
5
12
1
PW_BS000111
108
1
3
PW_BS000108
147
1
24
1
PW_BS000147
159
24
PW_BS000159
35
5
19
1
4
PW_BS000035
117
1
3
1
PW_BS000117
188
1
18
PW_BS000024
163
2
18
1
PW_BS000163
205
5
6
1
PW_BS000024
160
1
18
1
PW_BS000160
213
7
18
1
PW_BS000024
210
13
18
1
PW_BS000024
212
1
7
18
1
PW_BS000024
170
18
PW_BS000170
225
35
4
1
PW_BS000024
151
1
4
1
PW_BS000151
224
2
4
1
PW_BS000024
198
5
18
1
PW_BS000024
211
10
18
PW_BS000024
222
3
4
1
PW_BS000024
164
4
PW_BS000164
286
36
4
1
PW_BS000024
226
4
4
1
PW_BS000024
249
13
4
1
PW_BS000024
315
1
23
PW_BS000024
322
1
23
1
PW_BS000024
293
4
1
PW_BS000024
132
1
12
1
PW_BS000132
331
7
12
1
PW_BS000028
332
1
7
12
1
PW_BS000028
130
13
12
1
PW_BS000130
112
2
12
1
PW_BS000112
115
10
12
PW_BS000115
336
1
12
1
PW_BS000028
119
2
17
1
PW_BS000119
94
3
PW_BS000094
407
2
5
1
PW_BS000115
405
10
5
PW_BS000115
122
5
5
1
PW_BS000122
123
1
7
5
1
PW_BS000123
125
13
5
1
PW_BS000125
429
1
5
1
PW_BS000115
124
1
5
1
PW_BS000124
383
7
5
1
PW_BS000100
376
10
17
PW_BS000053
135
5
17
1
PW_BS000135
447
1
7
17
1
PW_BS000115
136
13
17
1
PW_BS000136
464
1
17
1
PW_BS000115
118
1
17
1
PW_BS000118
398
7
17
1
PW_BS000113
481
2
10
1
PW_BS000115
297
5
10
1
PW_BS000024
299
1
10
1
PW_BS000024
495
7
10
1
PW_BS000115
206
2
6
1
PW_BS000024
388
1
6
1
PW_BS000112
390
7
6
1
PW_BS000112
4
3
1
1
PW_BS000004
15
11
1
PW_BS000015
26
1
1
1
5
PW_BS000026
54
1
3
1
5
PW_BS000054
17
12
1
1
PW_BS000017
22
14
1
1
PW_BS000022
42
24
1
1
PW_BS000042
70
28
5
1
1
PW_BS000070
103
3
3
1
PW_BS000103
107
31
3
PW_BS000107
100
5
2
1
PW_BS000100
105
11
3
PW_BS000105
155
3
24
1
PW_BS000155
157
2
24
1
PW_BS000157
161
3
18
1
PW_BS000161
166
1
1
PW_BS000166
178
3
21
1
PW_BS000178
152
8
4
PW_BS000152
101
5
3
1
PW_BS000101
187
31
18
PW_BS000024
219
31
4
PW_BS000024
220
1
4
PW_BS000024
162
12
18
1
PW_BS000162
195
13
18
PW_BS000024
281
1
25
1
PW_BS000024
285
10
4
1
PW_BS000024
287
53
4
1
PW_BS000024
227
34
4
1
PW_BS000024
223
12
4
1
PW_BS000024
294
11
4
1
PW_BS000024
308
10
1
1
PW_BS000024
318
31
23
PW_BS000024
312
5
23
1
PW_BS000024
320
11
23
PW_BS000024
133
3
12
1
PW_BS000133
134
12
12
1
PW_BS000134
114
11
12
PW_BS000114
327
1
1
12
5
PW_BS000028
347
1
3
12
5
PW_BS000028
345
24
12
1
PW_BS000028
368
3
60
1
PW_BS000028
310
31
2
PW_BS000024
304
1
2
PW_BS000024
109
32
3
PW_BS000109
406
3
5
1
PW_BS000115
409
11
5
PW_BS000115
424
1
1
5
5
PW_BS000115
425
1
3
5
5
PW_BS000115
418
24
5
1
PW_BS000115
384
12
5
1
PW_BS000100
120
3
17
1
PW_BS000120
137
11
17
PW_BS000137
459
1
1
17
5
PW_BS000115
460
1
3
17
5
PW_BS000115
454
24
17
1
PW_BS000115
121
12
17
1
PW_BS000121
479
3
10
1
PW_BS000115
483
11
10
PW_BS000115
489
24
10
1
PW_BS000115
480
12
10
1
PW_BS000115
300
13
10
1
PW_BS000024
501
3
6
1
PW_BS000115
208
11
6
PW_BS000024
506
24
6
1
PW_BS000115
391
12
6
1
PW_BS000112
395
13
6
1
PW_BS000113
334
4
12
1
PW_BS000028
408
4
5
1
PW_BS000115
374
4
17
1
PW_BS000053
482
4
10
1
PW_BS000115
502
4
6
1
PW_BS000115
146
NADPH
HMDB0000221
Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed.).
53-57-6
C00005
22833512
16474
NADPH
17215925
NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O
C21H30N7O17P3
InChI=1S/C21H30N7O17P3/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32/h1,3-4,7-8,10-11,13-16,20-21,29-31H,2,5-6H2,(H2,23,32)(H,36,37)(H,38,39)(H2,22,24,25)(H2,33,34,35)/t10-,11-,13-,14-,15-,16-,20-,21-/m0/s1
ACFIXJIJDZMPPO-NCHANQSKSA-N
{[(2S,3S,4S,5S)-2-(6-amino-9H-purin-9-yl)-5-[({[({[(2S,3R,4S,5S)-5-(3-carbamoyl-1,4-dihydropyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-4-hydroxyoxolan-3-yl]oxy}phosphonic acid
745.4209
745.091102105
-2.14
9
[(2S,3S,4S,5S)-2-(6-aminopurin-9-yl)-5-{[({[(2S,3R,4S,5S)-5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy(hydroxy)phosphoryl}oxy(hydroxy)phosphoryl)oxy]methyl}-4-hydroxyoxolan-3-yl]oxyphosphonic acid
0
-4
FDB021909
2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-b-d-ribofuranosylnicotinamide;2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide;Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-d-ribofuranosyl-3-pyridinecarboxamide;Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide;Dihydrocodehydrogenase ii;Dihydronicotinamide adenine dinucleotide phosphate;Dihydronicotinamide adenine dinucleotide-p;Dihydrotriphosphopyridine nucleotide reduced;Nadp-reduced;Nadph;Nicotinamide-adenine-dinucleotide-phosphorate;Nicotinamide-adenine-dinucleotide-phosphoric acid;Reduced codehydrase ii;Reduced coenzyme ii;Reduced cozymase ii;Reduced triphosphopyridine nucleotide;Triphosphopyridine nucleotide reduced;B-nadph;B-nicotinamide-adenine-dinucleotide-phosphorate;B-nicotinamide-adenine-dinucleotide-phosphoric acid;Beta-nadph;Beta-nicotinamide-adenine-dinucleotide-phosphorate;Beta-nicotinamide-adenine-dinucleotide-phosphoric acid;Nicotinamide adenine dinucleotide phosphate - reduced
PW_C000146
NADPH
185
8
190
3
778
10
796
5
821
18
837
2
1609
29
1615
49
4687
31
4793
14
4797
14
5310
111
5789
108
5972
147
6128
159
6271
35
6779
117
7068
188
7103
163
7154
205
7205
160
7315
213
7345
210
7559
212
7591
170
8194
225
8219
151
8421
224
11812
198
11893
211
12006
222
12150
164
12245
286
12596
226
12648
249
42343
315
43746
322
76911
293
77166
132
77385
331
77394
332
77460
130
77504
112
77511
115
77623
336
80712
119
113164
94
120105
407
120425
405
120452
122
120616
123
121141
125
121275
429
121402
124
121483
383
123059
376
123086
135
123241
447
123712
136
123846
464
123961
118
124041
398
125472
481
125696
297
126214
299
126529
495
127009
206
127572
388
128101
390
40034
Hydrogen Ion
HMDB0059597
Hydrogen ion is recommended by IUPAC as a general term for all ions of hydrogen and its isotopes. Depending on the charge of the ion, two different classes can be distinguished: positively charged ions and negatively charged ions. Under aqueous conditions found in biochemistry, hydrogen ions exist as the hydrated form hydronium, H3O+, but these are often still referred to as hydrogen ions or even protons by biochemists. [WikiPedia])
C00080
1038
15378
1010
[H+]
H
InChI=1S/p+1
GPRLSGONYQIRFK-UHFFFAOYSA-N
hydron
1.0079
1.007825032
0
hydron
1
0
H+;H(+);Hydrogen cation;Hydron;Proton
PW_C040034
H+
215
4
670
8
753
15
788
31
848
3
1116
2
1463
26
1464
54
2231
49
2780
17
4250
22
4254
42
4547
10
4576
18
4694
70
5241
103
5327
111
5353
112
5626
108
5639
107
5699
100
5720
105
5742
117
5963
147
6037
155
6070
157
6093
161
6130
159
6232
166
6483
178
6601
152
6692
101
6843
188
6910
187
7100
163
7168
205
7191
206
7453
219
7454
220
7472
222
7525
213
7532
210
7558
212
7572
160
7590
170
8195
225
8218
151
8243
226
8413
162
8420
224
9139
195
9155
249
11915
164
12015
281
12181
285
12246
286
12266
287
12521
227
13257
223
13325
294
15330
308
42329
315
42354
318
42401
322
42405
312
42454
320
76912
293
77136
133
77210
134
77372
331
77804
114
77955
132
77990
327
77991
347
78379
345
79929
130
80019
368
80387
310
80388
304
80722
119
93823
124
94823
383
110550
388
112855
94
113280
390
115537
398
115539
118
115856
336
116205
109
119973
406
120193
407
120549
122
120593
409
121170
424
121171
425
122569
418
122615
384
122687
125
122758
120
123183
135
123218
137
123742
459
123743
460
125141
454
125188
121
125273
136
125359
479
125550
481
125730
483
125736
297
125809
299
126517
495
126717
489
126766
480
126823
300
126902
501
127213
208
128308
506
128361
391
128430
395
143
NADP
HMDB0000217
Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5-phosphate (NMN) coupled by pyrophosphate linkage to the 5-phosphate adenosine 2,5-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed.) Hydrogen carrier in biochemical redox systems. In the hexose monophosphoric acid system it is reduced to Dihydrocoenzyme II and reoxidation in the presence of flavoproteins (Dictionary of Organic Compounds).
53-59-8
C00006
5886
18009
NAD(P)
5675
NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O
C21H29N7O17P3
InChI=1S/C21H28N7O17P3/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32/h1-4,7-8,10-11,13-16,20-21,29-31H,5-6H2,(H7-,22,23,24,25,32,33,34,35,36,37,38,39)/p+1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1
XJLXINKUBYWONI-NNYOXOHSSA-O
1-[(2R,3R,4S,5R)-5-[({[({[(2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxy-4-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-3,4-dihydroxyoxolan-2-yl]-3-carbamoyl-1lambda5-pyridin-1-ylium
744.4129
744.083277073
-2.27
9
1-[(2R,3R,4S,5R)-5-{[({[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-hydroxy-4-(phosphonooxy)oxolan-2-yl]methoxy(hydroxy)phosphoryl}oxy(hydroxy)phosphoryl)oxy]methyl}-3,4-dihydroxyoxolan-2-yl]-3-carbamoyl-1lambda5-pyridin-1-ylium
1
-3
FDB021908
Adenine-nicotinamide dinucleotide phosphate;Codehydrase ii;Codehydrogenase ii;Coenzyme ii;Cozymase ii;Nad phosphate;Nadp;Nadp+;Nicotinamide adenine dinucleotide phosphate;Nicotinamide-adenine dinucleotide phosphate;Tpn;Triphosphopyridine nucleotide;B-nadp;B-nicotinamide adenine dinucleotide phosphate;B-tpn;Beta-nadp;Beta-nicotinamide adenine dinucleotide phosphate;Beta-tpn;Oxidized nicotinamide-adenine dinucleotide phosphate;B-nicotinamide adenine dinucleotide phosphoric acid;Beta-nicotinamide adenine dinucleotide phosphoric acid;β-nicotinamide adenine dinucleotide phosphate;β-nicotinamide adenine dinucleotide phosphoric acid
PW_C000143
NADP
183
8
191
3
768
5
780
10
824
18
839
2
1611
29
1617
49
4685
31
4796
14
4801
14
5308
111
5790
108
6017
147
6132
159
6273
35
6778
117
7069
188
7105
163
7152
205
7206
160
7317
213
7346
210
7562
212
7589
170
8197
225
8220
151
8419
224
11811
198
11897
211
12008
222
12152
164
12249
286
12597
226
12650
249
42344
315
43745
322
76913
293
77164
132
77384
331
77396
332
77461
130
77515
115
77624
336
77814
334
77870
112
80713
119
113165
94
120106
407
120429
405
120450
122
120604
408
120618
123
121142
125
121277
429
121401
124
121485
383
123063
376
123084
135
123229
374
123243
447
123713
136
123848
464
123960
118
124043
398
125473
481
125694
297
125743
482
126215
299
126528
495
127010
206
127225
502
127570
388
128100
390
72
oxidized thioredoxin
Compound
PW_EC000072
15033
ChEBI
OT
73
reduced thioredoxin
Compound
PW_EC000073
15033
ChEBI
RT
227
oxidized electron acceptor
Compound
Compound
PW_EC000227
ox-e
237
reduced electron acceptor
Compound
Compound
PW_EC000237
red-e
6134
Thioredoxin reductase
P0A9P4
Involved in oxidation-reduction process. Thioredoxin + NADP(+) = thioredoxin disulfide + NADPH.
trxB
b0888
AP009048
3
1.8.1.9
8901
101
4073
thioredoxin reductase
25
PW_P004073
11084
6134
2
6782
117
6080
false
PW_R006080
Right
24879
72
1
ElementCollection
false
24880
146
1
Compound
false
24881
40034
1
Compound
false
24882
73
1
ElementCollection
false
24883
143
1
Compound
false
6043
4073
1.8.1.9
6081
true
PW_R006081
Right
24884
73
1
ElementCollection
false
24885
227
1
ElementCollection
false
24886
72
1
ElementCollection
false
24887
237
1
ElementCollection
false
71407
146
62
false
447
279
10
regular
50
30
71408
40034
55
false
548
269
10
regular
78
78
71409
143
61
false
907
298
10
regular
50
30
1503
72
37
false
307
322
12
regular
100
90
1504
73
37
false
1002
323
12
regular
100
90
1505
227
37
false
907
1093
12
regular
100
90
1506
237
37
false
402
1092
12
regular
100
90
32714
6134
101
6
false
652
338
8
subunit
regular
160
80
27496
4073
1835
32395
32714
101373
M472 309 C472 383 609 378 652 378
5
false
18
101374
M587 347 C586 373 622 378 652 378
5
false
18
101375
M932 328 C931 382 842 378 812 378
5
false
18
true
M 25.946855044164835 59.82311706448356 L 11 58.56156076818752 L 17.380887721185843 72.13669509126586
false
101376
M407 377 C437 377 622 378 652 378
5
false
18
101377
M1002 378 C972 378 842 378 812 378
5
false
18
true
M 25.946855044164835 59.82311706448356 L 11 58.56156076818752 L 17.380887721185843 72.13669509126586
false
101378
M1150 751 C1196 742 1153 778 1153 808
5
true
18
101379
M452 1092 C452 1012 957 1004 957 1093
5
false
18
true
M 809.4799291903271 848.3075676219361 L 820 859 L 823.9998826628141 844.5431352401803
false
101380
M357 432 C358 461 358 990 358 1025 C430 1026 982 1032 1054 1031 C1053 1002 1053 455 1052 433
5
false
18
true
M 342.7786825995171 256.5198112262534 L 327.8318275553522 255.2582549299574 L 334.21271527653806 268.8333892530357
false
101381
M452 1092 C549 1093 950 1026 957 1093
5
true
18
true
M 342.7786825995171 256.5198112262534 L 327.8318275553522 255.2582549299574 L 334.21271527653806 268.8333892530357
false
20716
1835
6080
80498
71407
101373
Left
80499
71408
101374
Left
80500
71409
101375
Right
1740
1503
101376
Left
1741
1504
101377
Right
20898
6043
27496
20717
1835
6081
1742
1504
101378
Left
1743
1505
101379
Left
1744
1503
101380
Right
1745
1506
101381
Right
186461
477
468
1.0
1.0
0
2
92
479
481
3580
M125 225 C125 175 175 125 225 125 C513 125 888 125 1176 125 C1226 125 1276 175 1276 225 C1276 543 1276 958 1276 1276 C1276 1326 1226 1376 1176 1376 C888 1376 513 1376 225 1376 C175 1376 125 1326 125 1276 C125 958 125 543 125 225
1
true
6
1151.0
1251.0
3581
M225 325 C225 275 275 225 325 225 C552 225 846 225 1073 225 C1123 225 1173 275 1173 325 C1173 580 1173 911 1173 1166 C1173 1216 1123 1266 1073 1266 C846 1266 552 1266 325 1266 C275 1266 225 1216 225 1166 C225 911 225 580 225 325
1
true
6
948.0
1041.0