1863
Pathway
Ethanolamine Metabolism
Ethanolamine, in E. coli, is produced through phospholipid biosynthesis. Once in the cytosol it can be used to produce acetaldehyde by reacting with ethanolamine ammonia-lyase resulting in the release of ammonium and acetaldehyde.
Metabolic
PW002094
Center
PathwayVisualizationContext2381
1100
1300
#000099
PathwayVisualization1847
1863
Ethanolamine Metabolism
Ethanolamine, in E. coli, is produced through phospholipid biosynthesis. Once in the cytosol it can be used to produce acetaldehyde by reacting with ethanolamine ammonia-lyase resulting in the release of ammonium and acetaldehyde.
Metabolic
3
109865
968
SubPathway
109396
96
Compound
3929
1090845
Chang GW, Chang JT: Evidence for the B12-dependent enzyme ethanolamine deaminase in Salmonella. Nature. 1975 Mar 13;254(5496):150-1.
1863
Pathway
3930
6374020
Jones PW, Turner JM: Interrelationships between the enzymes of ethanolamine metabolism in Escherichia coli. J Gen Microbiol. 1984 Feb;130(2):299-308. doi: 10.1099/00221287-130-2-299.
1863
Pathway
3931
6376700
Jones PW, Turner JM: A model for the common control of enzymes of ethanolamine catabolism in Escherichia coli. J Gen Microbiol. 1984 Apr;130(4):849-60. doi: 10.1099/00221287-130-4-849.
1863
Pathway
3932
16585748
Penrod JT, Roth JR: Conserving a volatile metabolite: a role for carboxysome-like organelles in Salmonella enterica. J Bacteriol. 2006 Apr;188(8):2865-74. doi: 10.1128/JB.188.8.2865-2874.2006.
1863
Pathway
3933
784902
Scarlett FA, Turner JM: Microbial metabolism of amino alcohols. Ethanolamine catabolism mediated by coenzyme B12-dependent ethanolamine ammonia-lyase in Escherichia coli and Klebsiella aerogenes. J Gen Microbiol. 1976 Jul;95(1):173-6. doi: 10.1099/00221287-95-1-173.
1863
Pathway
1
Cell
CL:0000000
1
Homo sapiens
9606
Eukaryote
Human
4
Arabidopsis thaliana
3702
Eukaryote
Thale cress
12
Mus musculus
10090
Eukaryote
Mouse
5
Bos taurus
9913
Eukaryote
Cattle
6
Caenorhabditis elegans
6239
Eukaryote
Roundworm
17
Rattus norvegicus
10116
Eukaryote
Rat
10
Drosophila melanogaster
7227
Eukaryote
Fruit fly
3
Escherichia coli
562
Prokaryote
2
Bacteria
2
Prokaryote
Bacteria
18
Saccharomyces cerevisiae
4932
Eukaryote
Yeast
23
Pseudomonas aeruginosa
287
Prokaryote
5
Cytoplasm
GO:0005737
13
Endoplasmic Reticulum
GO:0005783
1
Cytosol
GO:0005829
7
Endoplasmic Reticulum Membrane
GO:0005789
35
Chloroplast
GO:0009507
32
Inner Membrane
GO:0070258
20
Endoplasmic Reticulum Lumen
GO:0005788
4
Peroxisome
GO:0005777
2
Mitochondrion
GO:0005739
1
Liver
BTO:0000759
72
9
8
5
1
1
PW_BS000008
249
13
4
1
PW_BS000024
151
1
4
1
PW_BS000151
2
1
1
1
PW_BS000002
111
5
12
1
PW_BS000111
132
1
12
1
PW_BS000132
124
1
5
1
PW_BS000124
388
1
6
1
PW_BS000112
118
1
17
1
PW_BS000118
122
5
5
1
PW_BS000122
135
5
17
1
PW_BS000135
297
5
10
1
PW_BS000024
205
5
6
1
PW_BS000024
108
1
3
PW_BS000108
95
1
7
2
1
PW_BS000095
100
5
2
1
PW_BS000100
166
1
1
PW_BS000166
225
35
4
1
PW_BS000024
170
18
PW_BS000170
315
1
23
PW_BS000024
109
32
3
PW_BS000109
10
1
7
1
1
PW_BS000010
36
1
20
1
1
PW_BS000036
31
1
5
1
1
PW_BS000031
5
4
1
1
PW_BS000005
3
2
1
1
PW_BS000003
163
2
18
1
PW_BS000163
224
2
4
1
PW_BS000024
344
1
20
12
1
PW_BS000028
129
1
5
12
1
PW_BS000129
334
4
12
1
PW_BS000028
112
2
12
1
PW_BS000112
417
1
20
5
1
PW_BS000115
414
1
5
5
1
PW_BS000115
408
4
5
1
PW_BS000115
407
2
5
1
PW_BS000115
453
1
20
17
1
PW_BS000115
450
1
5
17
1
PW_BS000115
374
4
17
1
PW_BS000053
119
2
17
1
PW_BS000119
481
2
10
1
PW_BS000115
299
1
10
1
PW_BS000024
206
2
6
1
PW_BS000024
96
Ethanolamine
HMDB0000149
Ethanolamine is a viscous, hygroscopic amino alcohol with an ammoniacal odor. It is widely distributed in biological tissue and is a component of lecithin. It is used as a surfactant, fluorometric reagent, and to remove CO2 and H2S from natural gas and other gases.
141-43-5
C00189
700
16000
ETHANOL-AMINE
13835336
DB03994
NCCO
C2H7NO
InChI=1S/C2H7NO/c3-1-2-4/h4H,1-3H2
HZAXFHJVJLSVMW-UHFFFAOYSA-N
61.0831
61.052763851
FDB000769
1-amino-2-hydroxyethane;2-amino-1-ethanol;2-aminoethanol;2-aminoethyl alcohol;2-ethanolamine;2-hydroxyethanamine;2-hydroxyethylamine;Aethanolamin;Aminoethanol;Colamine;Envision conditioner pdd 9020;Ethanolamine;Ethylolamine;Glycinol;H-glycinol;Mea;Monoaethanolamin;Monoethanolamine;Olamine;B-aminoethanol;B-aminoethyl alcohol;B-ethanolamine;B-hydroxyethylamine;Beta-aminoethanol;Beta-aminoethyl alcohol;Beta-ethanolamine;Beta-hydroxyethylamine;Eta;2-amino-ethanol;2-aminoethan-1-ol;Hea;β-aminoethanol;β-aminoethyl alcohol;β-ethanolamine;β-hydroxyethylamine
PW_C000096
ETA
1564
8
9146
249
12174
151
15326
2
78542
111
79971
132
94825
124
113281
388
115538
118
121333
122
123903
135
126013
297
127465
205
22608
Ammonium
HMDB0041827
Ammonium is an important source of nitrogen for many plant species, especially those growing on hypoxic soils. However, it is also toxic to most crop species and is rarely applied as a sole nitrogen source. The ammonium (more obscurely: aminium) cation is a positively charged polyatomic cation with the chemical formula NH4+. It is formed by the protonation of ammonia (NH3). Ammonium is also a general name for positively charged or protonated substituted amines and quaternary ammonium cations (NR4+), where one or more hydrogen atoms are replaced by organic radical groups (indicated by R).
14798-03-9
C01342
16741146
28938
218
[NH4+]
H4N
InChI=1S/H3N/h1H3/p+1
QGZKDVFQNNGYKY-UHFFFAOYSA-O
18.0385
18.034374133
Ammonium ion;Ammonia ion;Ammonium;Ammonium chloride;Ammonium(1+);Azanium;Nh4+;[nh4]+;[nh4](+);Nh4(+)
PW_C022608
Ammon
5751
108
5892
95
5969
100
6226
166
8273
151
8367
225
11909
170
12470
249
42627
315
116281
109
784
Acetaldehyde
HMDB0000990
Acetaldehyde is a colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis. Small amounts of acetaldehyde are produced naturally through gut microbial fermentation. Acetaldehyde is produced through the action of alcohol dehydrogenase on ethanol and is somewhate more toxic than ethanol. Acetaldehyde is linked to most of the negative clinical effects of alcohol. It has been shown to increase the risk of developing cirrhosis of the liver, multiple forms of cancer, and alcoholism.
75-07-0
C00084
177
15343
ACETALD
172
CC=O
C2H4O
InChI=1S/C2H4O/c1-2-3/h2H,1H3
IKHGUXGNUITLKF-UHFFFAOYSA-N
44.0526
44.02621475
DBMET00328
FDB008297
Acetaldehyde;Acetic aldehyde;Aldehyde;Ethanal;Ethyl aldehyde;Acetaldehyd;Acetaldehydes;Azetaldehyd
PW_C000784
Ethanal
774
8
779
10
784
36
785
31
787
5
1794
2
1870
3
6911
163
8370
224
77186
132
77821
111
77825
344
77827
129
77828
334
78779
112
120611
122
120617
417
120619
414
120620
408
121459
407
122195
124
123236
135
123242
453
123244
450
123245
374
124017
119
124747
118
126089
481
126355
299
127544
206
127918
388
6239
Ethanolamine ammonia-lyase heavy chain
P0AEJ6
Involved in catalytic activity. Ethanolamine = acetaldehyde + NH(3).
eutB
b2441
AP009048
3
4.3.1.7
6381
Ethanolamine ammonia-lyase light chain
P19636
Involved in ethanolamine ammonia-lyase activity. Ethanolamine = acetaldehyde + NH(3).
eutC
b2440
AP009048
3
4.3.1.7
4083
ethanolamine ammonia-lyase
3
PW_P004083
11098
6239
6
11099
6381
6
6110
false
PW_R006110
Right
25007
96
1
Compound
false
25008
22608
1
Compound
false
25009
784
1
Compound
false
6071
4083
4.3.1.7
71602
96
3
false
589
314
10
regular
100
100
71603
22608
3
false
914
489
10
regular
100
100
71604
784
3
false
794
624
10
regular
100
100
32802
6239
17
false
779
279
8
subunit
regular
180
85
32803
6381
17
false
754
324
8
subunit
regular
180
85
27542
4083
1847
32483
32802
32484
32803
101631
M689 364 C719 364 724 364 754 364
5
false
18
101632
M914 539 C868 537 844 530 844 409
5
false
18
true
M 25.946855044164835 13.26155629629604 L 11 12 L 17.380887721185843 25.575134323078345
false
101633
M844 624 C844 592 844 476 844 409
5
false
18
true
M 25.946855044164835 13.26155629629604 L 11 12 L 17.380887721185843 25.575134323078345
false
3660858
M589 364 C559 364 504 362 474 362
5
false
18
true
M 2241.0096189432334 2531.5 L 2254 2524 L 2241.0096189432334 2516.5
false
20765
1847
6110
80687
71602
101631
Left
80688
71603
101632
Right
80689
71604
101633
Right
20941
6071
27542
109537
109865
1847
14
false
324
327
16
regular
106231
71602
3660858
Right
186493
373
421
0.8
0.8
0
2
92
479
481
3606
M225 325 C225 275 275 225 325 225 C522 225 777 225 974 225 C1024 225 1074 275 1074 325 C1074 461 1074 638 1074 774 C1074 824 1024 874 974 874 C777 874 522 874 325 874 C275 874 225 824 225 774 C225 638 225 461 225 325
1
true
6
849.0
649.0
3607
M125 225 C125 175 175 125 225 125 C483 125 817 125 1075 125 C1125 125 1175 175 1175 225 C1175 422 1175 678 1175 875 C1175 925 1125 975 1075 975 C817 975 483 975 225 975 C175 975 125 925 125 875 C125 678 125 422 125 225
1
true
6
1050.0
850.0