Reference/PubChem-compound 247
type: UnificationXref
id: 247
db: PubChem-compound

Reference/CAS 454-29-5
type: UnificationXref
id: 454-29-5
db: CAS

Reference/PubChem-compound 249
type: UnificationXref
id: 249
db: PubChem-compound

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

solute carrier family 44
type: Complex
component: solute carrier family 44 A1
component: Choline transporter-like protein 2

S-adenosylmethionine synthase isoform type-2
type: Protein
cellular location: Cytoplasm
entity reference: S-adenosylmethionine synthase isoform type-2

Methionine synthase
type: ProteinReference
xref: Reference/UniProt Q99707
organism: Homo sapiens

Reference/KEGG Compound C05330
type: UnificationXref
id: C05330
db: KEGG Compound

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Unknown
type: ProteinReference

Reference/HMDB HMDB0000092
type: UnificationXref
id: HMDB0000092
db: HMDB

Tetrahydrofolic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Tetrahydrofolic acid

Reference/HMDB HMDB0000097
type: UnificationXref
id: HMDB0000097
db: HMDB

Reference/HMDB HMDB0001185
type: UnificationXref
id: HMDB0001185
db: HMDB

βine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 247
xref: Reference/BioCyc BETAINE
xref: Reference/ChemSpider 242
xref: Reference/KEGG Compound C00719
xref: Reference/CAS 107-43-7
xref: Reference/ChEBI CHEBI 17750
xref: Reference/HMDB HMDB0000043
chemical formula: C5H11NO2
molecular weight: 117.07898
structure: ChemicalStructure/PW C000030

Alpha-aminoadipic semialdehyde dehydrogenase
type: Complex
component stoichiometry: Protein/287 Mitochondrion/Stoichiometry/4.0
cellular location: Mitochondrion
component: Alpha-aminoadipic semialdehyde dehydrogenase

Reference/ChEBI CHEBI 20506
type: UnificationXref
id: CHEBI:20506
db: ChEBI

Reference/ChEBI CHEBI 17115
type: UnificationXref
id: CHEBI:17115
db: ChEBI

Reference/ChEBI CHEBI 15611
type: UnificationXref
id: CHEBI:15611
db: ChEBI

Compound/PW C000185 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sarcosine
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/ChEBI CHEBI 17230
type: UnificationXref
id: CHEBI:17230
db: ChEBI

Reference/KEGG Compound C00440
type: UnificationXref
id: C00440
db: KEGG Compound

βine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: βine

5-Methyltetrahydrofolic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: 5-Methyltetrahydrofolic acid

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/PubChem-compound 6137
type: UnificationXref
id: 6137
db: PubChem-compound

ChemicalStructure/PW C040918
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc 5-METHYL-THF
type: UnificationXref
id: 5-METHYL-THF
db: BioCyc

Homocysteine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Homocysteine

S-adenosylmethionine synthase isoform type-2
type: ProteinReference
xref: Reference/UniProt P31153
organism: Homo sapiens

Compound/PW C000967 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: βine aldehyde
stoichiometric coefficient: 1.0

Reference/ChemSpider 18714427
type: UnificationXref
id: 18714427
db: ChemSpider

Reference/ChemSpider 244
type: UnificationXref
id: 244
db: ChemSpider

Water
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Water

Reference/ChemSpider 242
type: UnificationXref
id: 242
db: ChemSpider

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Glycine N-methyltransferase
type: ProteinReference
xref: Reference/UniProt Q14749
organism: Homo sapiens

Compound/PW C000185 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sarcosine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Compound/PW C000065/Stoichiometry/1.0
type: Stoichiometry
physical entity: Choline
stoichiometric coefficient: 1.0

βine
type: SmallMolecule
cellular location: Mitochondrion
entity reference: βine

Reference/PubChem-compound 49791978
type: UnificationXref
id: 49791978
db: PubChem-compound

TransportCatalysis1588
type: Catalysis
controller: Unknown
controlled: Transport522
control type: ACTIVATION

Glycine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Glycine

Betaine--homocysteine S-methyltransferase 1
type: Complex
component stoichiometry: Protein/530 Cytoplasm/Stoichiometry/4.0
cellular location: Cytoplasm
component: Betaine--homocysteine S-methyltransferase 1

S-Adenosylmethionine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24762165
xref: Reference/KEGG Compound C00019
xref: Reference/ChemSpider 31983
xref: Reference/ChEBI CHEBI 15414
xref: Reference/CAS 485-80-3
xref: Reference/BioCyc S-ADENOSYLMETHIONINE
xref: Reference/HMDB HMDB0001185
chemical formula: C15H23N6O5S
molecular weight: 399.14505
structure: ChemicalStructure/PW C000921

Glycine N-methyltransferase
type: Protein
cellular location: Cytoplasm
entity reference: Glycine N-methyltransferase

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/KEGG Compound C00576
type: UnificationXref
id: C00576
db: KEGG Compound

Reference/KEGG Compound C00213
type: UnificationXref
id: C00213
db: KEGG Compound

Reference/UniProt Q93088
type: UnificationXref
id: Q93088
db: UniProt

ChemicalStructure/PW C000548
type: ChemicalStructure
structure format: SMILES
structure data: CSCC[C@H](N)C(O)=O

Acceptor
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Acceptor

Reference/ChEBI CHEBI 15022
type: UnificationXref
id: CHEBI:15022
db: ChEBI

βine
type: SmallMolecule
entity reference: βine

Alpha-aminoadipic semialdehyde dehydrogenase
type: ProteinReference
xref: Reference/UniProt P49419
organism: Homo sapiens

Tetrahydrofolic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 20506
xref: Reference/ChemSpider 18714427
xref: Reference/HMDB HMDB0001846
xref: Reference/PubChem-compound 13781857
xref: Reference/BioCyc THF
xref: Reference/CAS 135-16-0
xref: Reference/KEGG Compound C00101
chemical formula: C19H23N7O6
molecular weight: 445.171
structure: ChemicalStructure/PW C001221

Reference/PubChem-compound 439175
type: UnificationXref
id: 439175
db: PubChem-compound

Reference/BioCyc BETAINE ALDEHYDE
type: UnificationXref
id: BETAINE_ALDEHYDE
db: BioCyc

Reference/CAS 107-43-7
type: UnificationXref
id: 107-43-7
db: CAS

Reference/UniProt Q9UI17
type: UnificationXref
id: Q9UI17
db: UniProt

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Compound/PW C040918 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tetrahydrofolate
stoichiometric coefficient: 1.0

ReactionCatalysis168
type: Catalysis
controller: S-adenosylmethionine synthase
controlled: 2.5.1.6
control type: ACTIVATION

Reference/ChemSpider 5736
type: UnificationXref
id: 5736
db: ChemSpider

ReactionCatalysis166
type: Catalysis
controller: Betaine--homocysteine S-methyltransferase 1
controlled: 2.1.1.5
control type: ACTIVATION

Serine hydroxymethyltransferase, cytosolic
type: Complex
component stoichiometry: Protein/739 Cytoplasm/Stoichiometry/4.0
cellular location: Cytoplasm
component: Serine hydroxymethyltransferase, cytosolic

solute carrier family 44 A1
type: ProteinReference
xref: Reference/UniProt Q8WWI5

ReactionCatalysis164
type: Catalysis
controller: Alpha-aminoadipic semialdehyde dehydrogenase
controlled: Reaction667
control type: ACTIVATION

2.1.1.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000590 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000062 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000030 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000548 Cytoplasm/Stoichiometry/1.0
right: L-Methionine
right: Dimethylglycine
spontaneous: false
EC number: 2.1.1.5
left: Homocysteine
left: βine
name: Homocysteine + βine → Dimethylglycine + L-Methionine
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc ADENOSYL-HOMO-CYS
type: UnificationXref
id: ADENOSYL-HOMO-CYS
db: BioCyc

Reference/ChEBI CHEBI 15710
type: UnificationXref
id: CHEBI:15710
db: ChEBI

ReactionCatalysis165
type: Catalysis
controller: Choline dehydrogenase, mitochondrial
controlled: 1.1.99.1
control type: ACTIVATION

Serine hydroxymethyltransferase, cytosolic
type: ProteinReference
xref: Reference/UniProt P34896
organism: Homo sapiens

Reaction667
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001144 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000967 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000030 Mitochondrion/Stoichiometry/1.0
right: NADH
right: βine
spontaneous: false
left: NAD
left: Water
left: βine aldehyde
name: NAD + Water + βine aldehyde → NADH + βine
conversion direction: LEFT_TO_RIGHT

Choline transporter-like protein 2
type: ProteinReference
xref: Reference/UniProt Q8IWA5

1.1.99.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000967 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000065 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/Generic40 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/Generic41 Mitochondrion/Stoichiometry/1.0
right: Reduced acceptor
right: βine aldehyde
spontaneous: false
EC number: 1.1.99.1
left: Choline
left: Acceptor
name: Acceptor + Choline → Reduced acceptor + βine aldehyde
conversion direction: LEFT_TO_RIGHT

Reference/CAS 485-80-3
type: UnificationXref
id: 485-80-3
db: CAS

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Reference/BioCyc METHYLENE-THF
type: UnificationXref
id: METHYLENE-THF
db: BioCyc

Sarcosine dehydrogenase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q9UL12
organism: Homo sapiens

Reference/CAS 7418-61-3
type: UnificationXref
id: 7418-61-3
db: CAS

Serine hydroxymethyltransferase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P34897
organism: Homo sapiens

Reference/BioCyc SER
type: UnificationXref
id: SER
db: BioCyc

Reference/KEGG Compound C00101
type: UnificationXref
id: C00101
db: KEGG Compound

Compound/PW C000921 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylmethionine
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001533
type: UnificationXref
id: HMDB0001533
db: HMDB

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

TransportCatalysis1590
type: Catalysis
controller: Unknown
controlled: Transport523
control type: ACTIVATION

Compound/PW C000030 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: βine
stoichiometric coefficient: 1.0

Protein/739 Cytoplasm/Stoichiometry/4.0
type: Stoichiometry
physical entity: Serine hydroxymethyltransferase, cytosolic
stoichiometric coefficient: 4.0

Mitochondrion
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005739

Reference/BioCyc THF
type: UnificationXref
id: THF
db: BioCyc

Compound/PW C000062/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dimethylglycine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15641
type: UnificationXref
id: CHEBI:15641
db: ChEBI

Reference/BioCyc GLY
type: UnificationXref
id: GLY
db: BioCyc

Compound/PW C000120 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Serine
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000921
type: ChemicalStructure
structure format: SMILES

Reference/CAS 979-92-0
type: UnificationXref
id: 979-92-0
db: CAS

S-Adenosylhomocysteine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: S-Adenosylhomocysteine

Compound/PW C000030 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: βine
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00114
type: UnificationXref
id: C00114
db: KEGG Compound

S-Adenosylhomocysteine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 25246222
xref: Reference/ChemSpider 388301
xref: Reference/BioCyc ADENOSYL-HOMO-CYS
xref: Reference/CAS 979-92-0
xref: Reference/KEGG Compound C00021
xref: Reference/ChEBI CHEBI 16680
xref: Reference/HMDB HMDB0000939
chemical formula: C14H20N6O5S
molecular weight: 384.12158
structure: ChemicalStructure/PW C000749

ChemicalStructure/PW C001221
type: ChemicalStructure
structure format: SMILES

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Water
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Water

Reference/BioCyc SARCOSINE
type: UnificationXref
id: SARCOSINE
db: BioCyc

Compound/PW C001178 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5,10-Methylene-THF
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000696
type: UnificationXref
id: HMDB0000696
db: HMDB

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Compound/Generic40 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Reduced acceptor
stoichiometric coefficient: 1.0

Serine hydroxymethyltransferase, cytosolic
type: Protein
cellular location: Cytoplasm
entity reference: Serine hydroxymethyltransferase, cytosolic

ReactionCatalysis1527
type: Catalysis
controller: Serine hydroxymethyltransferase, cytosolic
controlled: 2.1.2.1
control type: ACTIVATION

Glycine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000123
xref: Reference/BioCyc GLY
xref: Reference/ChemSpider 730
xref: Reference/PubChem-compound 5257127
xref: Reference/CAS 56-40-6
xref: Reference/ChEBI CHEBI 15428
xref: Reference/KEGG Compound C00037
chemical formula: C2H5NO2
molecular weight: 75.03203
structure: ChemicalStructure/PW C000078

ReactionCatalysis1520
type: Catalysis
controller: Glycine N-methyltransferase
controlled: 2.1.1.20
control type: ACTIVATION

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

5-Methyltetrahydrofolic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 5-Methyltetrahydrofolic acid

Reference/ChEBI CHEBI 15414
type: UnificationXref
id: CHEBI:15414
db: ChEBI

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Compound/Generic41 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acceptor
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/PubChem-compound 673
type: UnificationXref
id: 673
db: PubChem-compound

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/CAS 135-16-0
type: UnificationXref
id: 135-16-0
db: CAS

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/ChemSpider 388320
type: UnificationXref
id: 388320
db: ChemSpider

Reference/PubChem-compound 5257127
type: UnificationXref
id: 5257127
db: PubChem-compound

Reference/UniProt Q8NE62
type: UnificationXref
id: Q8NE62
db: UniProt

5,10-Methylene-THF
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001533
xref: Reference/CAS 3432-99-3
xref: Reference/PubChem-compound 439175
xref: Reference/ChEBI CHEBI 15636
xref: Reference/KEGG Compound C00143
xref: Reference/BioCyc METHYLENE-THF
xref: Reference/ChemSpider 388320
chemical formula: C20H23N7O6
molecular weight: 457.171
structure: ChemicalStructure/PW C001178

Reference/UniProt Q99707
type: UnificationXref
id: Q99707
db: UniProt

Protein/287 Mitochondrion/Stoichiometry/4.0
type: Stoichiometry
physical entity: Alpha-aminoadipic semialdehyde dehydrogenase
stoichiometric coefficient: 4.0

βine aldehyde
type: SmallMoleculeReference
xref: Reference/ChemSpider 244
xref: Reference/ChEBI CHEBI 15710
xref: Reference/PubChem-compound 249
xref: Reference/BioCyc BETAINE ALDEHYDE
xref: Reference/CAS 7418-61-3
xref: Reference/HMDB HMDB0001252
xref: Reference/KEGG Compound C00576
chemical formula: C5H12NO
molecular weight: 102.09189
structure: ChemicalStructure/PW C000967

Reference/KEGG Compound C00019
type: UnificationXref
id: C00019
db: KEGG Compound

Reference/PathWhiz PW002387
type: UnificationXref
id: PW002387
db: PathWhiz

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Methionine synthase
type: Protein
cellular location: Cytoplasm
entity reference: Methionine synthase

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine triphosphate

Reference/BioCyc S-ADENOSYLMETHIONINE
type: UnificationXref
id: S-ADENOSYLMETHIONINE
db: BioCyc

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Reference/PubChem-compound 5951
type: UnificationXref
id: 5951
db: PubChem-compound

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Sarcosine Oncometabolite Pathway
type: Pathway
pathway order: PathwayTransport/24963
pathway order: PathwayTransport/2156357
pathway order: PathwayEnzymeReaction/2512295
pathway order: PathwayTransport/2156359
pathway order: PathwayEnzymeReaction/2512304
pathway order: PathwayEnzymeReaction/2512306
pathway order: PathwayEnzymeReaction/2512305
pathway order: PathwayEnzymeReaction/2512311
pathway order: PathwayEnzymeReaction/2512310
pathway order: PathwayEnzymeReaction/2512312
pathway order: PathwayEnzymeReaction/2512308
pathway order: PathwayEnzymeReaction/2512307
pathway order: PathwayEnzymeReaction/2512309
pathway component: TransportCatalysis1588
pathway component: ReactionCatalysis207829
pathway component: ReactionCatalysis6175
pathway component: ReactionCatalysis6174
pathway component: ReactionCatalysis6173
pathway component: 2.1.2.1
pathway component: ReactionCatalysis1527
pathway component: Reaction6244
pathway component: Reaction6245
pathway component: ReactionCatalysis1520
pathway component: 2.5.1.6
pathway component: 2.1.1.13
pathway component: ReactionCatalysis168
pathway component: TransportCatalysis450
pathway component: ReactionCatalysis166
pathway component: ReactionCatalysis164
pathway component: 2.1.1.5
pathway component: ReactionCatalysis165
pathway component: Reaction667
pathway component: 1.1.99.1
pathway component: 2.1.1.20
pathway component: TransportCatalysis1590
pathway component: Transport521
pathway component: Transport523
pathway component: Transport522
xref: Reference/PathWhiz PW002387
xref: Reference/SMPDB SMP0002313
organism: Homo sapiens

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Sarcosine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Sarcosine

ChemicalStructure/PW C000590
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCS)C(O)=O

Compound/PW C000548 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Methionine
stoichiometric coefficient: 1.0

Reference/ChemSpider 388301
type: UnificationXref
id: 388301
db: ChemSpider

Reference/ChemSpider 1057
type: UnificationXref
id: 1057
db: ChemSpider

Reference/BioCyc CPD-563
type: UnificationXref
id: CPD-563
db: BioCyc

Reference/ChEBI CHEBI 15636
type: UnificationXref
id: CHEBI:15636
db: ChEBI

Reference/KEGG Compound C00143
type: UnificationXref
id: C00143
db: KEGG Compound

Reference/BioCyc MET
type: UnificationXref
id: MET
db: BioCyc

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/KEGG Compound C00021
type: UnificationXref
id: C00021
db: KEGG Compound

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Tetrahydrofolate
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Tetrahydrofolate

Reference/HMDB HMDB0000123
type: UnificationXref
id: HMDB0000123
db: HMDB

Compound/PW C001144 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000120
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CO)C(O)=O

Dimethylglycine
type: SmallMolecule
entity reference: Dimethylglycine

Choline dehydrogenase, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Choline dehydrogenase, mitochondrial

Compound/PW C000062 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dimethylglycine
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005739
type: UnificationXref
id: GO:0005739
db: GENE ONTOLOGY

Reference/CAS 3432-99-3
type: UnificationXref
id: 3432-99-3
db: CAS

Compound/PW C000078 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glycine
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Choline
type: SmallMolecule
entity reference: Choline

Reference/CAS 1118-68-9
type: UnificationXref
id: 1118-68-9
db: CAS

Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Choline
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15354
xref: Reference/ChemSpider 299
xref: Reference/BioCyc CPD-563
xref: Reference/PubChem-compound 305
xref: Reference/CAS 62-49-7
xref: Reference/HMDB HMDB0000097
xref: Reference/KEGG Compound C00114
chemical formula: C5H14NO
molecular weight: 104.10754
structure: ChemicalStructure/PW C000065

Sarcosine
type: SmallMoleculeReference
xref: Reference/CAS 107-97-1
xref: Reference/BioCyc SARCOSINE
xref: Reference/ChemSpider 1057
xref: Reference/ChEBI CHEBI 15611
xref: Reference/HMDB HMDB0000271
xref: Reference/KEGG Compound C00213
xref: Reference/PubChem-compound 1088
chemical formula: C3H7NO2
molecular weight: 89.047676
structure: ChemicalStructure/PW C000185

Dimethylglycine
type: SmallMoleculeReference
xref: Reference/BioCyc DIMETHYL-GLYCINE
xref: Reference/ChemSpider 653
xref: Reference/CAS 1118-68-9
xref: Reference/ChEBI CHEBI 17724
xref: Reference/HMDB HMDB0000092
xref: Reference/PubChem-compound 673
xref: Reference/KEGG Compound C01026
chemical formula: C4H9NO2
molecular weight: 103.06333
structure: ChemicalStructure/PW C000062

L-Methionine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000696
xref: Reference/ChEBI CHEBI 16643
xref: Reference/KEGG Compound C00073
xref: Reference/CAS 63-68-3
xref: Reference/BioCyc MET
xref: Reference/PubChem-compound 6137
xref: Reference/ChemSpider 5907
chemical formula: C5H11NO2S
molecular weight: 149.05106
structure: ChemicalStructure/PW C000548

Methionine adenosyltransferase 2 subunit beta
type: Protein
cellular location: Cytoplasm
entity reference: Methionine adenosyltransferase 2 subunit beta

Reference/UniProt Q9UL12
type: UnificationXref
id: Q9UL12
db: UniProt

ReactionCatalysis6175
type: Catalysis
controller: Serine hydroxymethyltransferase, mitochondrial
controlled: 2.1.2.1
control type: ACTIVATION

ReactionCatalysis6174
type: Catalysis
controller: Sarcosine dehydrogenase, mitochondrial
controlled: Reaction6245
control type: ACTIVATION

ReactionCatalysis6173
type: Catalysis
controller: Dimethylglycine dehydrogenase, mitochondrial
controlled: Reaction6244
control type: ACTIVATION

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Reference/KEGG Compound C03541
type: UnificationXref
id: C03541
db: KEGG Compound

Reference/KEGG Compound C00037
type: UnificationXref
id: C00037
db: KEGG Compound

ChemicalStructure/PW C000967
type: ChemicalStructure
structure format: SMILES
structure data: C[N+](C)(C)CC=O

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 653
type: UnificationXref
id: 653
db: ChemSpider

Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00719
type: UnificationXref
id: C00719
db: KEGG Compound

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

2.1.1.13
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000590 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001221 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001079 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000548 Cytoplasm/Stoichiometry/1.0
right: L-Methionine
right: Tetrahydrofolic acid
spontaneous: false
EC number: 2.1.1.13
left: Homocysteine
left: 5-Methyltetrahydrofolic acid
name: 5-Methyltetrahydrofolic acid + Homocysteine ↔ L-Methionine + Tetrahydrofolic acid
conversion direction: REVERSIBLE

Reference/ChEBI CHEBI 15339
type: UnificationXref
id: CHEBI:15339
db: ChEBI

Dimethylglycine dehydrogenase, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Dimethylglycine dehydrogenase, mitochondrial

Reference/ChEBI CHEBI 17750
type: UnificationXref
id: CHEBI:17750
db: ChEBI

Reference/PubChem-compound 1088
type: UnificationXref
id: 1088
db: PubChem-compound

Reference/HMDB HMDB0000939
type: UnificationXref
id: HMDB0000939
db: HMDB

Reference/CAS 107-97-1
type: UnificationXref
id: 107-97-1
db: CAS

ChemicalStructure/PW C000065
type: ChemicalStructure
structure format: SMILES
structure data: C[N+](C)(C)CCO

Compound/PW C000749 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylhomocysteine
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000185
type: ChemicalStructure
structure format: SMILES
structure data: CNCC(O)=O

Dimethylglycine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Dimethylglycine

Reference/SMPDB SMP0002313
type: UnificationXref
id: SMP0002313
db: SMPDB

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Transport521
type: Transport
participant stoichiometry: Compound/PW C000065 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000065/Stoichiometry/1.0
right: Choline
spontaneous: false
left: Choline
name: Choline (→) Transport: Homo sapiens, Cell to Homo sapiens, Cell, Mitochondrion
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000062
type: ChemicalStructure
structure format: SMILES
structure data: CN(C)CC(O)=O

Transport523
type: Transport
participant stoichiometry: Compound/PW C000062 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000062/Stoichiometry/1.0
right: Dimethylglycine
spontaneous: false
left: Dimethylglycine
name: Dimethylglycine (→) Transport: Homo sapiens, Cell to Homo sapiens, Cell, Mitochondrion
conversion direction: LEFT_TO_RIGHT

Transport522
type: Transport
participant stoichiometry: Compound/PW C000030/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000030 Mitochondrion/Stoichiometry/1.0
right: βine
spontaneous: false
left: βine
name: βine (→) Transport: Homo sapiens, Cell, Mitochondrion to Homo sapiens, Cell
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/PubChem-compound 305
type: UnificationXref
id: 305
db: PubChem-compound

Reference/ChEBI CHEBI 17724
type: UnificationXref
id: CHEBI:17724
db: ChEBI

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Methionine adenosyltransferase 2 subunit beta
type: ProteinReference
xref: Reference/UniProt Q9NZL9
organism: Homo sapiens

solute carrier family 44 A1
type: Protein
entity reference: solute carrier family 44 A1

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Acceptor
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15339

Choline transporter-like protein 2
type: Protein
entity reference: Choline transporter-like protein 2

Reduced acceptor
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15022

Reference/KEGG Compound C01026
type: UnificationXref
id: C01026
db: KEGG Compound

NAD
type: SmallMolecule
cellular location: Mitochondrion
entity reference: NAD

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Reduced acceptor
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Reduced acceptor

Serine hydroxymethyltransferase, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Serine hydroxymethyltransferase, mitochondrial

ChemicalStructure/PW C000030
type: ChemicalStructure
structure format: SMILES
structure data: C[N+](C)(C)CC([O-])=O

L-Methionine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Methionine

2.1.2.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001178 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000120 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001221 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000078 Cytoplasm/Stoichiometry/1.0
right: 5,10-Methylene-THF
right: Glycine
right: Water
spontaneous: false
EC number: 2.1.2.1
left: L-Serine
left: Tetrahydrofolic acid
name: L-Serine + Tetrahydrofolic acid ↔ 5,10-Methylene-THF + Glycine + Water
conversion direction: REVERSIBLE

Compound/PW C000030/Stoichiometry/1.0
type: Stoichiometry
physical entity: βine
stoichiometric coefficient: 1.0

Reference/CAS 63-68-3
type: UnificationXref
id: 63-68-3
db: CAS

Compound/PW C001221 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tetrahydrofolic acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000271
type: UnificationXref
id: HMDB0000271
db: HMDB

Reference/UniProt Q14749
type: UnificationXref
id: Q14749
db: UniProt

Reference/UniProt P31153
type: UnificationXref
id: P31153
db: UniProt

Compound/PW C000062 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dimethylglycine
stoichiometric coefficient: 1.0

Reference/ChemSpider 5907
type: UnificationXref
id: 5907
db: ChemSpider

L-Serine
type: SmallMolecule
cellular location: Mitochondrion
entity reference: L-Serine

Reference/ChEBI CHEBI 16643
type: UnificationXref
id: CHEBI:16643
db: ChEBI

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/UniProt P34897
type: UnificationXref
id: P34897
db: UniProt

Reference/UniProt P34896
type: UnificationXref
id: P34896
db: UniProt

Reference/CAS 56-40-6
type: UnificationXref
id: 56-40-6
db: CAS

Reference/KEGG Compound C00065
type: UnificationXref
id: C00065
db: KEGG Compound

Compound/PW C001079 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Methyltetrahydrofolic acid
stoichiometric coefficient: 1.0

Compound/PW C000120 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Serine
stoichiometric coefficient: 1.0

Pyrophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pyrophosphate

Tetrahydrofolate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C03541
chemical formula: C19H23N7O6
molecular weight: 445.171
structure: ChemicalStructure/PW C040918

2.1.1.20
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000749 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000185 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000078 Cytoplasm/Stoichiometry/1.0
right: Glycine
right: S-Adenosylmethionine
spontaneous: false
EC number: 2.1.1.20
left: Sarcosine
left: S-Adenosylhomocysteine
name: S-Adenosylhomocysteine + Sarcosine ↔ Glycine + S-Adenosylmethionine
conversion direction: REVERSIBLE

5-Methyltetrahydrofolic acid
type: SmallMoleculeReference
xref: Reference/BioCyc 5-METHYL-THF
xref: Reference/ChEBI CHEBI 15641
xref: Reference/PubChem-compound 439234
xref: Reference/CAS 134-35-0
xref: Reference/KEGG Compound C00440
xref: Reference/ChemSpider 388371
xref: Reference/HMDB HMDB0001396
chemical formula: C20H25N7O6
molecular weight: 459.18665
structure: ChemicalStructure/PW C001079

Reference/KEGG Compound C00073
type: UnificationXref
id: C00073
db: KEGG Compound

Sarcosine dehydrogenase, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Sarcosine dehydrogenase, mitochondrial

Protein/397 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: S-adenosylmethionine synthase isoform type-2
stoichiometric coefficient: 2.0

Reference/ChEBI CHEBI 15428
type: UnificationXref
id: CHEBI:15428
db: ChEBI

S-adenosylmethionine synthase
type: Complex
component stoichiometry: Protein/2387 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/397 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Methionine adenosyltransferase 2 subunit beta
component: S-adenosylmethionine synthase isoform type-2

Reference/HMDB HMDB0001252
type: UnificationXref
id: HMDB0001252
db: HMDB

NADH
type: SmallMolecule
cellular location: Mitochondrion
entity reference: NADH

Reference/HMDB HMDB0000043
type: UnificationXref
id: HMDB0000043
db: HMDB

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/BioCyc DIMETHYL-GLYCINE
type: UnificationXref
id: DIMETHYL-GLYCINE
db: BioCyc

Compound/PW C000590 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Homocysteine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

5,10-Methylene-THF
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 5,10-Methylene-THF

Reference/UniProt Q8WWI5
type: UnificationXref
id: Q8WWI5
db: UniProt

Reference/ChemSpider 31983
type: UnificationXref
id: 31983
db: ChemSpider

Protein/2387 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Methionine adenosyltransferase 2 subunit beta
stoichiometric coefficient: 1.0

Alpha-aminoadipic semialdehyde dehydrogenase
type: Protein
cellular location: Mitochondrion
entity reference: Alpha-aminoadipic semialdehyde dehydrogenase

Dimethylglycine
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Dimethylglycine

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/PubChem-compound 439234
type: UnificationXref
id: 439234
db: PubChem-compound

Reference/BioCyc BETAINE
type: UnificationXref
id: BETAINE
db: BioCyc

Reference/ChemSpider 730
type: UnificationXref
id: 730
db: ChemSpider

Reference/ChemSpider 299
type: UnificationXref
id: 299
db: ChemSpider

βine aldehyde
type: SmallMolecule
cellular location: Mitochondrion
entity reference: βine aldehyde

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Homocysteine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C05330
xref: Reference/CAS 454-29-5
xref: Reference/HMDB HMDB0000742
xref: Reference/ChEBI CHEBI 17230
xref: Reference/ChemSpider 757
xref: Reference/PubChem-compound 49791978
xref: Reference/BioCyc HOMO-CYS
chemical formula: C4H9NO2S
molecular weight: 135.0354
structure: ChemicalStructure/PW C000590

2.5.1.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000921 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000548 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
right: S-Adenosylmethionine
right: Phosphate
right: Pyrophosphate
spontaneous: false
EC number: 2.5.1.6
left: L-Methionine
left: Water
left: Adenosine triphosphate
name: Adenosine triphosphate + L-Methionine + Water → Phosphate + Pyrophosphate + S-Adenosylmethionine
conversion direction: LEFT_TO_RIGHT

Unknown
type: Protein
entity reference: Unknown

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

TransportCatalysis450
type: Catalysis
controller: solute carrier family 44
controlled: Transport521
control type: ACTIVATION

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/CAS 56-45-1
type: UnificationXref
id: 56-45-1
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Sarcosine
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Sarcosine

Compound/PW C000078 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glycine
stoichiometric coefficient: 1.0

Reference/UniProt Q8IWA5
type: UnificationXref
id: Q8IWA5
db: UniProt

Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphate

Reference/BioCyc HOMO-CYS
type: UnificationXref
id: HOMO-CYS
db: BioCyc

Choline dehydrogenase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q8NE62
organism: Homo sapiens

Reference/HMDB HMDB0000742
type: UnificationXref
id: HMDB0000742
db: HMDB

Dimethylglycine dehydrogenase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q9UI17
organism: Homo sapiens

ChemicalStructure/PW C001079
type: ChemicalStructure
structure format: SMILES

L-Serine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Serine

L-Serine
type: SmallMoleculeReference
xref: Reference/ChemSpider 5736
xref: Reference/ChEBI CHEBI 17115
xref: Reference/CAS 56-45-1
xref: Reference/KEGG Compound C00065
xref: Reference/PubChem-compound 5951
xref: Reference/HMDB HMDB0000187
xref: Reference/BioCyc SER
chemical formula: C3H7NO3
molecular weight: 105.042595
structure: ChemicalStructure/PW C000120

Reference/HMDB HMDB0000187
type: UnificationXref
id: HMDB0000187
db: HMDB

Reference/HMDB HMDB0001396
type: UnificationXref
id: HMDB0001396
db: HMDB

Protein/530 Cytoplasm/Stoichiometry/4.0
type: Stoichiometry
physical entity: Betaine--homocysteine S-methyltransferase 1
stoichiometric coefficient: 4.0

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

ReactionCatalysis207829
type: Catalysis
controller: Methionine synthase
controlled: 2.1.1.13
control type: ACTIVATION

Reference/UniProt Q9NZL9
type: UnificationXref
id: Q9NZL9
db: UniProt

Reference/ChemSpider 388371
type: UnificationXref
id: 388371
db: ChemSpider

Compound/PW C001079 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Methyltetrahydrofolic acid
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000749
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 757
type: UnificationXref
id: 757
db: ChemSpider

Reference/PubChem-compound 25246222
type: UnificationXref
id: 25246222
db: PubChem-compound

Compound/PW C000065 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Choline
stoichiometric coefficient: 1.0

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

ChemicalStructure/PW C000078
type: ChemicalStructure
structure format: SMILES
structure data: NCC(O)=O

Glycine
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Glycine

Reaction6244
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040918 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000185 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001079 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000062 Mitochondrion/Stoichiometry/1.0
right: Sarcosine
right: 5-Methyltetrahydrofolic acid
spontaneous: false
left: Dimethylglycine
left: Tetrahydrofolate
name: Dimethylglycine + Tetrahydrofolate → 5-Methyltetrahydrofolic acid + Sarcosine
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Reaction6245
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040918 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000078 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000185 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001079 Mitochondrion/Stoichiometry/1.0
right: Glycine
right: 5-Methyltetrahydrofolic acid
spontaneous: false
left: Sarcosine
left: Tetrahydrofolate
name: Sarcosine + Tetrahydrofolate → 5-Methyltetrahydrofolic acid + Glycine
conversion direction: LEFT_TO_RIGHT

2.1.2.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040918 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000078 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001079 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000120 Mitochondrion/Stoichiometry/1.0
right: Glycine
right: 5-Methyltetrahydrofolic acid
spontaneous: false
EC number: 2.1.2.1
left: L-Serine
left: Tetrahydrofolate
name: L-Serine + Tetrahydrofolate ↔ 5-Methyltetrahydrofolic acid + Glycine
conversion direction: REVERSIBLE

Choline
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Choline

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Reference/ChEBI CHEBI 15354
type: UnificationXref
id: CHEBI:15354
db: ChEBI

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/HMDB HMDB0001846
type: UnificationXref
id: HMDB0001846
db: HMDB

Reference/ChEBI CHEBI 16680
type: UnificationXref
id: CHEBI:16680
db: ChEBI

Reference/CAS 62-49-7
type: UnificationXref
id: 62-49-7
db: CAS

Betaine--homocysteine S-methyltransferase 1
type: Protein
cellular location: Cytoplasm
entity reference: Betaine--homocysteine S-methyltransferase 1

Reference/UniProt P49419
type: UnificationXref
id: P49419
db: UniProt

Betaine--homocysteine S-methyltransferase 1
type: ProteinReference
xref: Reference/UniProt Q93088
organism: Homo sapiens

Reference/PubChem-compound 24762165
type: UnificationXref
id: 24762165
db: PubChem-compound

ChemicalStructure/PW C001178
type: ChemicalStructure
structure format: SMILES

Reference/CAS 134-35-0
type: UnificationXref
id: 134-35-0
db: CAS

Reference/PubChem-compound 13781857
type: UnificationXref
id: 13781857
db: PubChem-compound

Compound/PW C000721 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

S-Adenosylmethionine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: S-Adenosylmethionine