N-docosanoyl-4-hydroxysphinganine
type: SmallMolecule
entity reference: N-docosanoyl-4-hydroxysphinganine

Reference/PubChem-compound 25203083
type: UnificationXref
id: 25203083
db: PubChem-compound

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/BioCyc DEHYDROSPHINGANINE
type: UnificationXref
id: DEHYDROSPHINGANINE
db: BioCyc

Reference/ChemSpider 17220830
type: UnificationXref
id: 17220830
db: ChemSpider

Compound/PW C001065/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

ReactionCatalysis6338
type: Catalysis
controller: Serine palmitoyltransferase 1
controlled: 2.3.1.50
control type: ACTIVATION

ReactionCatalysis6337
type: Catalysis
controller: 3-ketosphinganine reductase
controlled: 1.1.1.102
control type: ACTIVATION

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

ReactionCatalysis6336
type: Catalysis
controller: dihydrosphingosine C-4 hydroxylase
controlled: 1.-.-.-
control type: ACTIVATION

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

Reference/ChEBI CHEBI 17115
type: UnificationXref
id: CHEBI:17115
db: ChEBI

trans-docos-2-enoyl-CoA
type: SmallMolecule
entity reference: trans-docos-2-enoyl-CoA

ReactionCatalysis6341
type: Catalysis
controller: 3-oxoacyl-[acyl-carrier-protein] reductase
controlled: Reaction6413
control type: ACTIVATION

(3R)-3-hydroxy-arachidoyl-CoA
type: SmallMoleculeReference
xref: Reference/PubChem-compound 72193813
chemical formula: C41H70N7O18P3S
molecular weight: 1073.3733
structure: ChemicalStructure/PW C044539

(3R)-3-hydroxy-docosanoyl-CoA
type: SmallMolecule
entity reference: (3R)-3-hydroxy-docosanoyl-CoA

ReactionCatalysis6340
type: Catalysis
controller: 3-ketoacyl-CoA synthase ELO1
controlled: Reaction6412
control type: ACTIVATION

(3R)-3-hydroxy-stearoyl-CoA
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 76374
chemical formula: C39H66N7O18P3S
molecular weight: 1045.342
structure: ChemicalStructure/PW C044536

Reference/BioCyc CPD-10279
type: UnificationXref
id: CPD-10279
db: BioCyc

Reference/PubChem-compound 5281
type: UnificationXref
id: 5281
db: PubChem-compound

3-oxoicosanoyl-CoA
type: SmallMoleculeReference
xref: Reference/PubChem-compound 70678676
chemical formula: C42H70N7O18P3S
molecular weight: 1085.3733
structure: ChemicalStructure/PW C044537

Reference/KEGG Compound C01530
type: UnificationXref
id: C01530
db: KEGG Compound

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/ChemSpider 388366
type: UnificationXref
id: 388366
db: ChemSpider

Reference/HMDB HMDB0006529
type: UnificationXref
id: HMDB0006529
db: HMDB

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

3-oxodocosanoyl-CoA
type: SmallMolecule
entity reference: 3-oxodocosanoyl-CoA

(2E)-eicosenoyl-CoA
type: SmallMolecule
entity reference: (2E)-eicosenoyl-CoA

3-oxodocosanoyl-CoA
type: SmallMoleculeReference
xref: Reference/PubChem-compound 25203083
chemical formula: C43H76N7O18P3S
molecular weight: 1103.4181
structure: ChemicalStructure/PW C044541

Compound/Generic259/Stoichiometry/1.0
type: Stoichiometry
physical entity: ferricytochrome b5
stoichiometric coefficient: 1.0

Reference/UniProt P39002
type: UnificationXref
id: P39002
db: UniProt

(3R)-3-hydroxy-docosanoyl-CoA
type: SmallMoleculeReference
xref: Reference/PubChem-compound 72193817
chemical formula: C43H74N7O18P3S
molecular weight: 1101.4045
structure: ChemicalStructure/PW C044542

(2E)-eicosenoyl-CoA
type: SmallMoleculeReference
xref: Reference/PubChem-compound 71627315
xref: Reference/HMDB HMDB0062227
chemical formula: C41H72N7O17P3S
molecular weight: 1059.3918
structure: ChemicalStructure/PW C044540

trans-docos-2-enoyl-CoA
type: SmallMoleculeReference
xref: Reference/PubChem-compound 71627306
xref: Reference/HMDB HMDB0062226
chemical formula: C43H76N7O17P3S
molecular weight: 1087.4231
structure: ChemicalStructure/PW C044543

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

ReactionCatalysis6354
type: Catalysis
controller: Ceramide synthase subunit LIP1
controlled: Reaction6426
control type: ACTIVATION

Reference/CAS 24330-89-0
type: UnificationXref
id: 24330-89-0
db: CAS

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

N-docosanoyl-4-hydroxysphinganine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 67024
chemical formula: C40H81NO4
molecular weight: 639.6166
structure: ChemicalStructure/PW C044556

Reference/ChemSpider 5736
type: UnificationXref
id: 5736
db: ChemSpider

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Saccharomyces cerevisiae
type: BioSource
xref: Reference/TAXONOMY 4932

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Compound/PW C000032/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

Compound/PW C000146/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Compound/PW C001031/Stoichiometry/1.0
type: Stoichiometry
physical entity: Palmitoyl-CoA
stoichiometric coefficient: 1.0

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

Reference/HMDB HMDB0004258
type: UnificationXref
id: HMDB0004258
db: HMDB

Stearoyl-CoA
type: SmallMoleculeReference
xref: Reference/CAS 362-66-3
xref: Reference/ChEBI CHEBI 15541
xref: Reference/HMDB HMDB0001114
xref: Reference/KEGG Compound C00412
xref: Reference/BioCyc STEAROYL-COA
xref: Reference/ChemSpider 388366
xref: Reference/PubChem-compound 439229
chemical formula: C39H70N7O17P3S
molecular weight: 1033.3762
structure: ChemicalStructure/PW C000871

Reference/PubChem-compound 53477850
type: UnificationXref
id: 53477850
db: PubChem-compound

Reference/KEGG Compound C00249
type: UnificationXref
id: C00249
db: KEGG Compound

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/UniProt P25045
type: UnificationXref
id: P25045
db: UniProt

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Docosanoyl-CoA
type: SmallMolecule
entity reference: Docosanoyl-CoA

Docosanoyl-CoA
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0012930
xref: Reference/KEGG Compound C16528
xref: Reference/ChEBI CHEBI 65088
xref: Reference/BioCyc CPD-10279
xref: Reference/PubChem-compound 168166
xref: Reference/CAS 24330-89-0
chemical formula: C43H78N7O17P3S
molecular weight: 1089.4387
structure: ChemicalStructure/PW C008122

(3R)-3-hydroxy-stearoyl-CoA
type: SmallMolecule
entity reference: (3R)-3-hydroxy-stearoyl-CoA

Reference/ChemSpider 388895
type: UnificationXref
id: 388895
db: ChemSpider

3-oxoicosanoyl-CoA
type: SmallMolecule
entity reference: 3-oxoicosanoyl-CoA

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

(3R)-3-hydroxy-arachidoyl-CoA
type: SmallMolecule
entity reference: (3R)-3-hydroxy-arachidoyl-CoA

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Reference/PubChem-compound 122121
type: UnificationXref
id: 122121
db: PubChem-compound

Reference/CAS 554-62-1
type: UnificationXref
id: 554-62-1
db: CAS

Endocytosis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway112357
pathway component: SubPathwayInteraction112357
name: SubPathway

ReactionCatalysis6317
type: Catalysis
controller: Peroxisomal acyl-coenzyme A thioester hydrolase 1
controlled: 3.1.2.2
control type: ACTIVATION

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Stearoyl-CoA
type: SmallMolecule
entity reference: Stearoyl-CoA

1.-.-.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Protein/Generic260/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002151/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000184/Stoichiometry/1.0
participant stoichiometry: Compound/Generic259/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/2.0
right: Water
right: Phytosphingosine
right: ferricytochrome b5
spontaneous: false
EC number: 1.-.-.-
left: Sphinganine
left: Hydrogen Ion
left: Oxygen
left: ferrocytochrome b5
name: 2 Hydrogen Ion + Oxygen + Sphinganine + ferrocytochrome b5 → Phytosphingosine + Water + ferricytochrome b5
conversion direction: LEFT_TO_RIGHT

1.1.1.102
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001139/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000184/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Sphinganine
right: NADP
spontaneous: false
EC number: 1.1.1.102
left: Hydrogen Ion
left: NADPH
left: 3-Dehydrosphinganine
name: 3-Dehydrosphinganine + Hydrogen Ion + NADPH → NADP + Sphinganine
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis6312
type: Catalysis
controller: 3-ketoacyl-CoA synthase ELO1
controlled: 2.3.1.199
control type: ACTIVATION

ReactionCatalysis6316
type: Catalysis
controller: 2-enoyl thioester reductase
controlled: 1.3.1.10,1.3.1.38
control type: ACTIVATION

Reference/HMDB HMDB0062227
type: UnificationXref
id: HMDB0062227
db: HMDB

ReactionCatalysis6315
type: Catalysis
controller: Peroxisomal hydratase-dehydrogenase-epimerase
controlled: 4.2.1.119,1.1.1.n12
control type: ACTIVATION

ReactionCatalysis6314
type: Catalysis
controller: 3-oxoacyl-[acyl-carrier-protein] reductase
controlled: 1.1.1.100
control type: ACTIVATION

ReactionCatalysis6313
type: Catalysis
controller: Acyl-CoA synthase
controlled: 6.2.1.3
control type: ACTIVATION

Reference/HMDB HMDB0062226
type: UnificationXref
id: HMDB0062226
db: HMDB

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

ChemicalStructure/PW C000911
type: ChemicalStructure
structure format: SMILES

Compound/PW C044541/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-oxodocosanoyl-CoA
stoichiometric coefficient: 1.0

ReactionCatalysis6323
type: Catalysis
controller: 3-oxoacyl-[acyl-carrier-protein] reductase
controlled: Reaction6397
control type: ACTIVATION

ReactionCatalysis6322
type: Catalysis
controller: 3-ketoacyl-CoA synthase ELO1
controlled: Reaction6396
control type: ACTIVATION

ReactionCatalysis6321
type: Catalysis
controller: 2-enoyl thioester reductase
controlled: Reaction6395
control type: ACTIVATION

Compound/PW C000143/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

ReactionCatalysis6320
type: Catalysis
controller: Peroxisomal hydratase-dehydrogenase-epimerase
controlled: Reaction6394
control type: ACTIVATION

ReactionCatalysis6325
type: Catalysis
controller: 2-enoyl thioester reductase
controlled: Reaction6399
control type: ACTIVATION

ReactionCatalysis6324
type: Catalysis
controller: Peroxisomal hydratase-dehydrogenase-epimerase
controlled: Reaction6398
control type: ACTIVATION

Compound/PW C044536/Stoichiometry/1.0
type: Stoichiometry
physical entity: (3R)-3-hydroxy-stearoyl-CoA
stoichiometric coefficient: 1.0

ferricytochrome b5
type: SmallMoleculeReference

Reference/KEGG Compound C00154
type: UnificationXref
id: C00154
db: KEGG Compound

ChemicalStructure/PW C001139
type: ChemicalStructure
structure format: SMILES
structure data: CCCCCCCCCCCCCCCC(=O)[C@@H](N)CO

Reaction6426
type: BiochemicalReaction
participant stoichiometry: Compound/PW C044556/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002151/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099/Stoichiometry/1.0
participant stoichiometry: Compound/PW C008122/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Coenzyme A
right: Hydrogen Ion
right: N-docosanoyl-4-hydroxysphinganine
spontaneous: false
left: Phytosphingosine
left: Docosanoyl-CoA
name: Docosanoyl-CoA + Phytosphingosine → Coenzyme A + Hydrogen Ion + N-docosanoyl-4-hydroxysphinganine
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

Water
type: SmallMolecule
entity reference: Water

Reference/HMDB HMDB0004610
type: UnificationXref
id: HMDB0004610
db: HMDB

ChemicalStructure/PW C002111
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc STEARIC ACID
type: UnificationXref
id: STEARIC_ACID
db: BioCyc

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/PubChem-compound 16061151
type: UnificationXref
id: 16061151
db: PubChem-compound

Compound/PW C001139/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Dehydrosphinganine
stoichiometric coefficient: 1.0

Compound/PW C002796/Stoichiometry/1.0
type: Stoichiometry
physical entity: (2E)-Octadecenoyl-CoA
stoichiometric coefficient: 1.0

Compound/PW C000661/Stoichiometry/1.0
type: Stoichiometry
physical entity: Stearic acid
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001031
type: ChemicalStructure
structure format: SMILES

Compound/PW C000170/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001114
type: UnificationXref
id: HMDB0001114
db: HMDB

ChemicalStructure/PW C000184
type: ChemicalStructure
structure format: SMILES
structure data: CCCCCCCCCCCCCCC[C@@H](O)[C@@H](N)CO

3-ketoacyl-CoA synthase ELO1
type: ProteinReference
xref: Reference/UniProt P39540

Reference/PubChem-compound 72193813
type: UnificationXref
id: 72193813
db: PubChem-compound

Reference/HMDB HMDB0000269
type: UnificationXref
id: HMDB0000269
db: HMDB

Long-chain-fatty-acid--CoA ligase 2
type: ProteinReference
xref: Reference/UniProt P39518

Reference/PubChem-compound 72193817
type: UnificationXref
id: 72193817
db: PubChem-compound

Reference/KEGG Compound C12144
type: UnificationXref
id: C12144
db: KEGG Compound

Serine palmitoyltransferase 1
type: ProteinReference
xref: Reference/UniProt P25045

2.3.1.50
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001139/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001031/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000120/Stoichiometry/1.0
right: Coenzyme A
right: Carbon dioxide
right: 3-Dehydrosphinganine
spontaneous: false
EC number: 2.3.1.50
left: Palmitoyl-CoA
left: Hydrogen Ion
left: L-Serine
name: Hydrogen Ion + L-Serine + Palmitoyl-CoA ? 3-Dehydrosphinganine + Carbon dioxide + Coenzyme A

Reaction6412
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000871/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316/Stoichiometry/1.0
participant stoichiometry: Compound/PW C044537/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000911/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Coenzyme A
right: 3-oxoicosanoyl-CoA
right: Carbon dioxide
spontaneous: false
left: Stearoyl-CoA
left: Hydrogen Ion
left: Malonyl-CoA
name: Hydrogen Ion + Malonyl-CoA + Stearoyl-CoA → 3-oxoicosanoyl-CoA + Carbon dioxide + Coenzyme A
conversion direction: LEFT_TO_RIGHT

Reaction6413
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146/Stoichiometry/1.0
participant stoichiometry: Compound/PW C044537/Stoichiometry/1.0
participant stoichiometry: Compound/PW C044539/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: NADP
right: (3R)-3-hydroxy-arachidoyl-CoA
spontaneous: false
left: 3-oxoicosanoyl-CoA
left: Hydrogen Ion
left: NADPH
name: 3-oxoicosanoyl-CoA + Hydrogen Ion + NADPH → (3R)-3-hydroxy-arachidoyl-CoA + NADP
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 70678676
type: UnificationXref
id: 70678676
db: PubChem-compound

Reference/UniProt P30624
type: UnificationXref
id: P30624
db: UniProt

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/CAS 16105-69-4
type: UnificationXref
id: 16105-69-4
db: CAS

Reference/BioCyc ICOSANOYL-COA
type: UnificationXref
id: ICOSANOYL-COA
db: BioCyc

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

3-ketosphinganine reductase
type: ProteinReference
xref: Reference/UniProt P38342

dihydrosphingosine C-4 hydroxylase
type: ProteinReference
xref: Reference/UniProt P38992

Reference/UniProt P38225
type: UnificationXref
id: P38225
db: UniProt

Peroxisomal hydratase-dehydrogenase-epimerase
type: ProteinReference
xref: Reference/UniProt Q02207

3-oxoacyl-[acyl-carrier-protein] reductase
type: ProteinReference
xref: Reference/UniProt P35731

Peroxisomal acyl-coenzyme A thioester hydrolase 1
type: ProteinReference
xref: Reference/UniProt P41903

2-enoyl thioester reductase
type: ProteinReference
xref: Reference/UniProt P38071

Reference/HMDB HMDB0001480
type: UnificationXref
id: HMDB0001480
db: HMDB

long chain fatty acyl:CoA synthetase
type: ProteinReference
xref: Reference/UniProt P47912

Reference/CAS 57-10-3
type: UnificationXref
id: 57-10-3
db: CAS

Reference/UniProt P38342
type: UnificationXref
id: P38342
db: UniProt

Very long-chain fatty acid transport protein
type: ProteinReference
xref: Reference/UniProt P38225

Long-chain-fatty-acid--CoA ligase 3
type: ProteinReference
xref: Reference/UniProt P39002

Long-chain-fatty-acid--CoA ligase 1
type: ProteinReference
xref: Reference/UniProt P30624

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Compound/PW C044537/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-oxoicosanoyl-CoA
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00065
type: UnificationXref
id: C00065
db: KEGG Compound

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

Reference/KEGG Compound C16528
type: UnificationXref
id: C16528
db: KEGG Compound

Stearic acid
type: SmallMolecule
entity reference: Stearic acid

Stearic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 28842
xref: Reference/PubChem-compound 5281
xref: Reference/ChemSpider 5091
xref: Reference/KEGG Compound C01530
xref: Reference/BioCyc STEARIC ACID
xref: Reference/HMDB HMDB0000827
xref: Reference/CAS 57-11-4
chemical formula: C18H36O2
molecular weight: 284.27155
structure: ChemicalStructure/PW C000661

Ceramide synthase subunit LIP1
type: ProteinReference
xref: Reference/UniProt A6ZN14

Reference/UniProt P39540
type: UnificationXref
id: P39540
db: UniProt

Reference/PubChem-compound 22833663
type: UnificationXref
id: 22833663
db: PubChem-compound

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Protein/Generic260/Stoichiometry/1.0
type: Stoichiometry
physical entity: ferrocytochrome b5
stoichiometric coefficient: 1.0

Compound/PW C044556/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-docosanoyl-4-hydroxysphinganine
stoichiometric coefficient: 1.0

Compound/PW C044543/Stoichiometry/1.0
type: Stoichiometry
physical entity: trans-docos-2-enoyl-CoA
stoichiometric coefficient: 1.0

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

(2E)-Octadecenoyl-CoA
type: SmallMolecule
entity reference: (2E)-Octadecenoyl-CoA

Reference/KEGG Compound C00083
type: UnificationXref
id: C00083
db: KEGG Compound

3-oxooctadecanoyl-CoA
type: SmallMoleculeReference
xref: Reference/ChemSpider 17216373
xref: Reference/HMDB HMDB0006498
xref: Reference/KEGG Compound C16216
xref: Reference/CAS 86370-20-9
xref: Reference/PubChem-compound 22833663
chemical formula: C39H68N7O18P3S
molecular weight: 1047.3555
structure: ChemicalStructure/PW C002775

Compound/PW C000145/Stoichiometry/1.0
type: Stoichiometry
physical entity: Palmitic acid
stoichiometric coefficient: 1.0

Compound/PW C044542/Stoichiometry/1.0
type: Stoichiometry
physical entity: (3R)-3-hydroxy-docosanoyl-CoA
stoichiometric coefficient: 1.0

ChemicalStructure/PW C002151
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/CAS 57-11-4
type: UnificationXref
id: 57-11-4
db: CAS

Reference/ChemSpider 960
type: UnificationXref
id: 960
db: ChemSpider

L-Serine
type: SmallMolecule
entity reference: L-Serine

Reference/ChEBI CHEBI 46961
type: UnificationXref
id: CHEBI:46961
db: ChEBI

L-Serine
type: SmallMoleculeReference
xref: Reference/ChemSpider 5736
xref: Reference/ChEBI CHEBI 17115
xref: Reference/CAS 56-45-1
xref: Reference/KEGG Compound C00065
xref: Reference/PubChem-compound 5951
xref: Reference/HMDB HMDB0000187
xref: Reference/BioCyc SER
chemical formula: C3H7NO3
molecular weight: 105.042595
structure: ChemicalStructure/PW C000120

Reference/UniProt P38992
type: UnificationXref
id: P38992
db: UniProt

Reference/HMDB HMDB0000187
type: UnificationXref
id: HMDB0000187
db: HMDB

Reference/PubChem-compound 985
type: UnificationXref
id: 985
db: PubChem-compound

Reference/UniProt P39518
type: UnificationXref
id: P39518
db: UniProt

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Reference/TAXONOMY 4932
type: UnificationXref
id: 4932
db: TAXONOMY

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

ferrocytochrome b5
type: Protein
entity reference: ferrocytochrome b5

3-oxooctadecanoyl-CoA
type: SmallMolecule
entity reference: 3-oxooctadecanoyl-CoA

Reference/PubChem-compound 10663
type: UnificationXref
id: 10663
db: PubChem-compound

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Reference/KEGG Compound C02041
type: UnificationXref
id: C02041
db: KEGG Compound

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Carbon dioxide
type: SmallMolecule
entity reference: Carbon dioxide

Reference/ChEBI CHEBI 76374
type: UnificationXref
id: CHEBI:76374
db: ChEBI

Reference/HMDB HMDB0001175
type: UnificationXref
id: HMDB0001175
db: HMDB

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

1.3.1.10,1.3.1.38
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000871/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002796/Stoichiometry/1.0
right: Stearoyl-CoA
right: NADP
spontaneous: false
EC number: 1.3.1.10,1.3.1.38
left: (2E)-Octadecenoyl-CoA
left: Hydrogen Ion
left: NADPH
name: (2E)-Octadecenoyl-CoA + Hydrogen Ion + NADPH → NADP + Stearoyl-CoA
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 71627315
type: UnificationXref
id: 71627315
db: PubChem-compound

3.1.2.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000661/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000871/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Coenzyme A
right: Stearic acid
right: Hydrogen Ion
spontaneous: false
EC number: 3.1.2.2
left: Water
left: Stearoyl-CoA
name: Stearoyl-CoA + Water → Coenzyme A + Hydrogen Ion + Stearic acid
conversion direction: LEFT_TO_RIGHT

Compound/PW C002151/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phytosphingosine
stoichiometric coefficient: 1.0

Reaction6394
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C044540/Stoichiometry/1.0
participant stoichiometry: Compound/PW C044539/Stoichiometry/1.0
right: Water
right: (2E)-eicosenoyl-CoA
spontaneous: false
left: (3R)-3-hydroxy-arachidoyl-CoA
name: (3R)-3-hydroxy-arachidoyl-CoA → (2E)-eicosenoyl-CoA + Water
conversion direction: LEFT_TO_RIGHT

Eicosanoyl-CoA
type: SmallMolecule
entity reference: Eicosanoyl-CoA

Reference/BioCyc PHYTOSPINGOSINE
type: UnificationXref
id: PHYTOSPINGOSINE
db: BioCyc

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/KEGG Compound C16216
type: UnificationXref
id: C16216
db: KEGG Compound

2.3.1.199
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001031/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000911/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002775/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Coenzyme A
right: Carbon dioxide
right: 3-oxooctadecanoyl-CoA
spontaneous: false
EC number: 2.3.1.199
left: Palmitoyl-CoA
left: Hydrogen Ion
left: Malonyl-CoA
name: Hydrogen Ion + Malonyl-CoA + Palmitoyl-CoA → 3-oxooctadecanoyl-CoA + Carbon dioxide + Coenzyme A
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C16218
type: UnificationXref
id: C16218
db: KEGG Compound

6.2.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000032/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001031/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000145/Stoichiometry/1.0
right: Palmitoyl-CoA
right: Adenosine monophosphate
right: Pyrophosphate
spontaneous: false
EC number: 6.2.1.3
left: Coenzyme A
left: Palmitic acid
left: Adenosine triphosphate
name: Adenosine triphosphate + Coenzyme A + Palmitic acid → Adenosine monophosphate + Palmitoyl-CoA + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

Pyrophosphate
type: SmallMolecule
entity reference: Pyrophosphate

1.1.1.100
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146/Stoichiometry/1.0
participant stoichiometry: Compound/PW C044536/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002775/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: (3R)-3-hydroxy-stearoyl-CoA
right: NADP
spontaneous: false
EC number: 1.1.1.100
left: Hydrogen Ion
left: NADPH
left: 3-oxooctadecanoyl-CoA
name: 3-oxooctadecanoyl-CoA + Hydrogen Ion + NADPH → (3R)-3-hydroxy-stearoyl-CoA + NADP
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P41903
type: UnificationXref
id: P41903
db: UniProt

4.2.1.119,1.1.1.n12
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C044536/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002796/Stoichiometry/1.0
right: Water
right: (2E)-Octadecenoyl-CoA
spontaneous: false
EC number: 4.2.1.119,1.1.1.n12
left: (3R)-3-hydroxy-stearoyl-CoA
name: (3R)-3-hydroxy-stearoyl-CoA → (2E)-Octadecenoyl-CoA + Water
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

3-Dehydrosphinganine
type: SmallMolecule
entity reference: 3-Dehydrosphinganine

Compound/PW C000414/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Reference/BioCyc PALMITYL-COA
type: UnificationXref
id: PALMITYL-COA
db: BioCyc

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Compound/PW C000184/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sphinganine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Ceramide synthase subunit LIP1
type: Protein
entity reference: Ceramide synthase subunit LIP1

Reference/PubChem-compound 439853
type: UnificationXref
id: 439853
db: PubChem-compound

SubPathwayInteraction112357
type: Interaction
name: SubPathwayReaction
name: SubPathway112357Reaction

(2E)-Octadecenoyl-CoA
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0006529
xref: Reference/PubChem-compound 53477850
xref: Reference/KEGG Compound C16218
chemical formula: C39H68N7O17P3S
molecular weight: 1031.3605
structure: ChemicalStructure/PW C002796

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Adenosine monophosphate
type: SmallMolecule
entity reference: Adenosine monophosphate

Peroxisomal hydratase-dehydrogenase-epimerase
type: Protein
entity reference: Peroxisomal hydratase-dehydrogenase-epimerase

2-enoyl thioester reductase
type: Protein
entity reference: 2-enoyl thioester reductase

Reference/PubChem-compound 71627306
type: UnificationXref
id: 71627306
db: PubChem-compound

Peroxisomal acyl-coenzyme A thioester hydrolase 1
type: Protein
entity reference: Peroxisomal acyl-coenzyme A thioester hydrolase 1

dihydrosphingosine C-4 hydroxylase
type: Protein
entity reference: dihydrosphingosine C-4 hydroxylase

long chain fatty acyl:CoA synthetase
type: Protein
entity reference: long chain fatty acyl:CoA synthetase

Long-chain-fatty-acid--CoA ligase 1
type: Protein
entity reference: Long-chain-fatty-acid--CoA ligase 1

Long-chain-fatty-acid--CoA ligase 3
type: Protein
entity reference: Long-chain-fatty-acid--CoA ligase 3

3-oxoacyl-[acyl-carrier-protein] reductase
type: Protein
entity reference: 3-oxoacyl-[acyl-carrier-protein] reductase

Very long-chain fatty acid transport protein
type: Protein
entity reference: Very long-chain fatty acid transport protein

NADPH
type: SmallMolecule
entity reference: NADPH

Reference/BioCyc SER
type: UnificationXref
id: SER
db: BioCyc

Palmitic acid
type: SmallMolecule
entity reference: Palmitic acid

NADP
type: SmallMolecule
entity reference: NADP

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

Reaction6395
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146/Stoichiometry/1.0
participant stoichiometry: Compound/PW C044540/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002111/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Eicosanoyl-CoA
right: NADP
spontaneous: false
left: Hydrogen Ion
left: (2E)-eicosenoyl-CoA
left: NADPH
name: (2E)-eicosenoyl-CoA + Hydrogen Ion + NADPH → Eicosanoyl-CoA + NADP
conversion direction: LEFT_TO_RIGHT

Palmitic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 985
xref: Reference/KEGG Compound C00249
xref: Reference/ChemSpider 960
xref: Reference/ChEBI CHEBI 15756
xref: Reference/BioCyc CPD-8475
xref: Reference/CAS 57-10-3
xref: Reference/HMDB HMDB0000220
chemical formula: C16H32O2
molecular weight: 256.24023
structure: ChemicalStructure/PW C000145

Reaction6396
type: BiochemicalReaction
participant stoichiometry: Compound/PW C044541/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000911/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002111/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Coenzyme A
right: Carbon dioxide
right: 3-oxodocosanoyl-CoA
spontaneous: false
left: Eicosanoyl-CoA
left: Hydrogen Ion
left: Malonyl-CoA
name: Eicosanoyl-CoA + Hydrogen Ion + Malonyl-CoA → 3-oxodocosanoyl-CoA + Carbon dioxide + Coenzyme A
conversion direction: LEFT_TO_RIGHT

Reaction6397
type: BiochemicalReaction
participant stoichiometry: Compound/PW C044541/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146/Stoichiometry/1.0
participant stoichiometry: Compound/PW C044542/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: (3R)-3-hydroxy-docosanoyl-CoA
right: NADP
spontaneous: false
left: Hydrogen Ion
left: 3-oxodocosanoyl-CoA
left: NADPH
name: 3-oxodocosanoyl-CoA + Hydrogen Ion + NADPH → (3R)-3-hydroxy-docosanoyl-CoA + NADP
conversion direction: LEFT_TO_RIGHT

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

Reaction6398
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C044543/Stoichiometry/1.0
participant stoichiometry: Compound/PW C044542/Stoichiometry/1.0
right: Water
right: trans-docos-2-enoyl-CoA
spontaneous: false
left: (3R)-3-hydroxy-docosanoyl-CoA
name: (3R)-3-hydroxy-docosanoyl-CoA → Water + trans-docos-2-enoyl-CoA
conversion direction: LEFT_TO_RIGHT

Reaction6399
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146/Stoichiometry/1.0
participant stoichiometry: Compound/PW C044543/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143/Stoichiometry/1.0
participant stoichiometry: Compound/PW C008122/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: NADP
right: Docosanoyl-CoA
spontaneous: false
left: trans-docos-2-enoyl-CoA
left: Hydrogen Ion
left: NADPH
name: Hydrogen Ion + NADPH + trans-docos-2-enoyl-CoA → Docosanoyl-CoA + NADP
conversion direction: LEFT_TO_RIGHT

3-ketosphinganine reductase
type: Protein
entity reference: 3-ketosphinganine reductase

Serine palmitoyltransferase 1
type: Protein
entity reference: Serine palmitoyltransferase 1

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Reference/ChEBI CHEBI 15525
type: UnificationXref
id: CHEBI:15525
db: ChEBI

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

ChemicalStructure/PW C002796
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

Reference/ChEBI CHEBI 28842
type: UnificationXref
id: CHEBI:28842
db: ChEBI

Phytosphingosine
type: SmallMolecule
entity reference: Phytosphingosine

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Reference/ChemSpider 5091
type: UnificationXref
id: 5091
db: ChemSpider

Oxygen
type: SmallMolecule
entity reference: Oxygen

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

3-ketoacyl-CoA synthase ELO1
type: Protein
entity reference: 3-ketoacyl-CoA synthase ELO1

Long-chain-fatty-acid--CoA ligase 2
type: Protein
entity reference: Long-chain-fatty-acid--CoA ligase 2

Reference/ChEBI CHEBI 15531
type: UnificationXref
id: CHEBI:15531
db: ChEBI

Reference/CAS 1763-10-6
type: UnificationXref
id: 1763-10-6
db: CAS

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000145
type: ChemicalStructure
structure format: SMILES
structure data: CCCCCCCCCCCCCCCC(O)=O

Reference/ChEBI CHEBI 15527
type: UnificationXref
id: CHEBI:15527
db: ChEBI

Compound/PW C008122/Stoichiometry/1.0
type: Stoichiometry
physical entity: Docosanoyl-CoA
stoichiometric coefficient: 1.0

Compound/PW C002775/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-oxooctadecanoyl-CoA
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000220
type: UnificationXref
id: HMDB0000220
db: HMDB

Compound/PW C000120/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Serine
stoichiometric coefficient: 1.0

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Reference/ChEBI CHEBI 65088
type: UnificationXref
id: CHEBI:65088
db: ChEBI

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

3-Dehydrosphinganine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 439853
xref: Reference/ChEBI CHEBI 17862
xref: Reference/ChemSpider 388895
xref: Reference/KEGG Compound C02934
xref: Reference/HMDB HMDB0001480
xref: Reference/CAS 16105-69-4
xref: Reference/BioCyc DEHYDROSPHINGANINE
chemical formula: C18H37NO2
molecular weight: 299.28244
structure: ChemicalStructure/PW C001139

Reference/PubChem-compound 5951
type: UnificationXref
id: 5951
db: PubChem-compound

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

ChemicalStructure/PW C002775
type: ChemicalStructure
structure format: SMILES

Eicosanoyl-CoA
type: SmallMoleculeReference
xref: Reference/PubChem-compound 16061151
xref: Reference/KEGG Compound C02041
xref: Reference/HMDB HMDB0004258
xref: Reference/ChEBI CHEBI 15527
xref: Reference/CAS 15895-27-9
xref: Reference/BioCyc ICOSANOYL-COA
xref: Reference/ChemSpider 17220830
chemical formula: C41H74N7O17P3S
molecular weight: 1061.4075
structure: ChemicalStructure/PW C002111

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Compound/PW C000871/Stoichiometry/1.0
type: Stoichiometry
physical entity: Stearoyl-CoA
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15756
type: UnificationXref
id: CHEBI:15756
db: ChEBI

Reference/CAS 15895-27-9
type: UnificationXref
id: 15895-27-9
db: CAS

Palmitoyl-CoA
type: SmallMoleculeReference
xref: Reference/PubChem-compound 15667
xref: Reference/ChemSpider 14902
xref: Reference/HMDB HMDB0001338
xref: Reference/ChEBI CHEBI 15525
xref: Reference/KEGG Compound C00154
xref: Reference/CAS 1763-10-6
xref: Reference/BioCyc PALMITYL-COA
chemical formula: C37H66N7O17P3S
molecular weight: 1005.34485
structure: ChemicalStructure/PW C001031

Sphinganine
type: SmallMolecule
entity reference: Sphinganine

ChemicalStructure/PW C000120
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CO)C(O)=O

Biosynthesis of Unsaturated Fatty Acids (Docosanoyl-CoA)
type: Pathway
pathway order: PathwayEnzymeReaction/25119
pathway order: PathwaySubPathway/112357
pathway order: PathwayEnzymeReaction/25122
pathway order: PathwayEnzymeReaction/25133
pathway order: PathwayEnzymeReaction/25123
pathway order: PathwayEnzymeReaction/25124
pathway order: PathwayEnzymeReaction/25125
pathway order: PathwayEnzymeReaction/25126
pathway order: PathwayEnzymeReaction/25127
pathway order: PathwayEnzymeReaction/25128
pathway order: PathwayEnzymeReaction/25129
pathway order: PathwayEnzymeReaction/25150
pathway order: PathwayEnzymeReaction/25130
pathway order: PathwayEnzymeReaction/25141
pathway order: PathwayEnzymeReaction/25120
pathway order: PathwayEnzymeReaction/25142
pathway order: PathwayEnzymeReaction/25121
pathway order: PathwayEnzymeReaction/25132
pathway order: PathwayEnzymeReaction/25143
pathway component: 1.3.1.10,1.3.1.38
pathway component: 3.1.2.2
pathway component: Reaction6394
pathway component: Reaction6426
pathway component: Endocytosis
pathway component: ReactionCatalysis6317
pathway component: 1.-.-.-
pathway component: 1.1.1.102
pathway component: ReactionCatalysis6312
pathway component: 2.3.1.199
pathway component: ReactionCatalysis6354
pathway component: 6.2.1.3
pathway component: 1.1.1.100
pathway component: ReactionCatalysis6316
pathway component: ReactionCatalysis6338
pathway component: 4.2.1.119,1.1.1.n12
pathway component: ReactionCatalysis6315
pathway component: ReactionCatalysis6337
pathway component: ReactionCatalysis6314
pathway component: ReactionCatalysis6336
pathway component: ReactionCatalysis6313
pathway component: ReactionCatalysis6341
pathway component: ReactionCatalysis6340
pathway component: Reaction6395
pathway component: ReactionCatalysis6323
pathway component: Reaction6396
pathway component: ReactionCatalysis6322
pathway component: ReactionCatalysis6321
pathway component: Reaction6397
pathway component: ReactionCatalysis6320
pathway component: Reaction6398
pathway component: Reaction6399
pathway component: 2.3.1.50
pathway component: ReactionCatalysis6325
pathway component: Reaction6412
pathway component: ReactionCatalysis6324
pathway component: Reaction6413
xref: Reference/SMPDB SMP0002329
xref: Reference/PathWhiz PW002408
organism: Saccharomyces cerevisiae

Palmitoyl-CoA
type: SmallMolecule
entity reference: Palmitoyl-CoA

Reference/HMDB HMDB0001338
type: UnificationXref
id: HMDB0001338
db: HMDB

Compound/PW C000911/Stoichiometry/1.0
type: Stoichiometry
physical entity: Malonyl-CoA
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 67024
type: UnificationXref
id: CHEBI:67024
db: ChEBI

Sphinganine
type: SmallMoleculeReference
xref: Reference/CAS 764-22-7
xref: Reference/ChEBI CHEBI 16566
xref: Reference/HMDB HMDB0000269
xref: Reference/KEGG Compound C00836
xref: Reference/PubChem-compound 91486
xref: Reference/ChemSpider 82609
chemical formula: C18H39NO2
molecular weight: 301.29807
structure: ChemicalStructure/PW C000184

Reference/ChEBI CHEBI 17862
type: UnificationXref
id: CHEBI:17862
db: ChEBI

Reference/UniProt P35731
type: UnificationXref
id: P35731
db: UniProt

ferricytochrome b5
type: SmallMolecule
entity reference: ferricytochrome b5

Reference/KEGG Compound C00836
type: UnificationXref
id: C00836
db: KEGG Compound

Compound/PW C002111/Stoichiometry/1.0
type: Stoichiometry
physical entity: Eicosanoyl-CoA
stoichiometric coefficient: 1.0

Reference/CAS 764-22-7
type: UnificationXref
id: 764-22-7
db: CAS

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

Reference/PubChem-compound 91486
type: UnificationXref
id: 91486
db: PubChem-compound

Reference/BioCyc STEAROYL-COA
type: UnificationXref
id: STEAROYL-COA
db: BioCyc

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

ChemicalStructure/PW C044556
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Reference/BioCyc CPD-8475
type: UnificationXref
id: CPD-8475
db: BioCyc

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/ChemSpider 82609
type: UnificationXref
id: 82609
db: ChemSpider

Coenzyme A
type: SmallMolecule
entity reference: Coenzyme A

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Reference/ChemSpider 10213
type: UnificationXref
id: 10213
db: ChemSpider

Reference/ChEBI CHEBI 15541
type: UnificationXref
id: CHEBI:15541
db: ChEBI

Reference/ChemSpider 14902
type: UnificationXref
id: 14902
db: ChemSpider

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/SMPDB SMP0002329
type: UnificationXref
id: SMP0002329
db: SMPDB

Reference/HMDB HMDB0012930
type: UnificationXref
id: HMDB0012930
db: HMDB

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

Compound/PW C044540/Stoichiometry/1.0
type: Stoichiometry
physical entity: (2E)-eicosenoyl-CoA
stoichiometric coefficient: 1.0

Compound/PW C044539/Stoichiometry/1.0
type: Stoichiometry
physical entity: (3R)-3-hydroxy-arachidoyl-CoA
stoichiometric coefficient: 1.0

Reference/CAS 524-14-1
type: UnificationXref
id: 524-14-1
db: CAS

Reference/HMDB HMDB0000827
type: UnificationXref
id: HMDB0000827
db: HMDB

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Compound/PW C001316/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/ChemSpider 108921
type: UnificationXref
id: 108921
db: ChemSpider

Reference/HMDB HMDB0006498
type: UnificationXref
id: HMDB0006498
db: HMDB

Phytosphingosine
type: SmallMoleculeReference
xref: Reference/CAS 554-62-1
xref: Reference/HMDB HMDB0004610
xref: Reference/BioCyc PHYTOSPINGOSINE
xref: Reference/ChemSpider 108921
xref: Reference/KEGG Compound C12144
xref: Reference/ChEBI CHEBI 46961
xref: Reference/PubChem-compound 122121
chemical formula: C18H39NO3
molecular weight: 317.293
structure: ChemicalStructure/PW C002151

Compound/PW C001099/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Reference/KEGG Compound C02934
type: UnificationXref
id: C02934
db: KEGG Compound

ferrocytochrome b5
type: ProteinReference

Reference/ChemSpider 17216373
type: UnificationXref
id: 17216373
db: ChemSpider

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Malonyl-CoA
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15531
xref: Reference/KEGG Compound C00083
xref: Reference/BioCyc MALONYL-COA
xref: Reference/CAS 524-14-1
xref: Reference/HMDB HMDB0001175
xref: Reference/PubChem-compound 10663
xref: Reference/ChemSpider 10213
chemical formula: C24H38N7O19P3S
molecular weight: 853.1156
structure: ChemicalStructure/PW C000911

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/CAS 56-45-1
type: UnificationXref
id: 56-45-1
db: CAS

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Reference/UniProt Q02207
type: UnificationXref
id: Q02207
db: UniProt

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Reference/UniProt P38071
type: UnificationXref
id: P38071
db: UniProt

ChemicalStructure/PW C000661
type: ChemicalStructure
structure format: SMILES
structure data: CCCCCCCCCCCCCCCCCC(O)=O

Reference/CAS 86370-20-9
type: UnificationXref
id: 86370-20-9
db: CAS

Reference/PubChem-compound 439229
type: UnificationXref
id: 439229
db: PubChem-compound

Reference/CAS 362-66-3
type: UnificationXref
id: 362-66-3
db: CAS

Reference/PubChem-compound 168166
type: UnificationXref
id: 168166
db: PubChem-compound

Reference/KEGG Compound C00412
type: UnificationXref
id: C00412
db: KEGG Compound

Malonyl-CoA
type: SmallMolecule
entity reference: Malonyl-CoA

Acyl-CoA synthase
type: Complex
component: long chain fatty acyl:CoA synthetase
component: Long-chain-fatty-acid--CoA ligase 1
component: Long-chain-fatty-acid--CoA ligase 3
component: Very long-chain fatty acid transport protein
component: Long-chain-fatty-acid--CoA ligase 2

ChemicalStructure/PW C000871
type: ChemicalStructure
structure format: SMILES

Compound/PW C040034/Stoichiometry/2.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 2.0

Reference/PubChem-compound 15667
type: UnificationXref
id: 15667
db: PubChem-compound

ChemicalStructure/PW C044537
type: ChemicalStructure
structure format: SMILES

Reference/UniProt A6ZN14
type: UnificationXref
id: A6ZN14
db: UniProt

ChemicalStructure/PW C044539
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 16566
type: UnificationXref
id: CHEBI:16566
db: ChEBI

ChemicalStructure/PW C044536
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/UniProt P47912
type: UnificationXref
id: P47912
db: UniProt

ChemicalStructure/PW C044541
type: ChemicalStructure
structure format: SMILES

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

ChemicalStructure/PW C044540
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc MALONYL-COA
type: UnificationXref
id: MALONYL-COA
db: BioCyc

ChemicalStructure/PW C044543
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C008122
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C044542
type: ChemicalStructure
structure format: SMILES

Reference/PathWhiz PW002408
type: UnificationXref
id: PW002408
db: PathWhiz