6-hydroxymethyl-7,8-dihydropterin diphosphate
mitochondrial C1-tetrahydrofolate synthase
7,8-Dihydropteroic acid + Adenosine triphosphate + L-Glutamic acid → 7,8-dihydrofolate monoglutamate + Adenosine diphosphate + Hydrogen Ion + Phosphate
7,8-dihydrofolate monoglutamate + Hydrogen Ion + NADPH → NADP + Tetrahydrofolate
10-Formyltetrahydrofolate + 5'-Phosphoribosyl-N-formylglycinamide → 5'-Phosphoribosyl-N-formylglycinamide + Tetrahydrofolate
Dihydroneopterin triphosphate + Water → Dihydroneopterin phosphate + Hydrogen Ion + Pyrophosphate
Dihydroneopterin phosphate + Water → 7,8-Dihydroneopterin + Phosphate
7,8-Dihydroneopterin → 6-hydroxymethyl-7,8-dihydropterin + Glycolaldehyde
6-hydroxymethyl-7,8-dihydropterin + Adenosine triphosphate → 6-hydroxymethyl-7,8-dihydropterin diphosphate + Adenosine monophosphate + Hydrogen Ion
6-hydroxymethyl-7,8-dihydropterin diphosphate + p-Aminobenzoic acid → 7,8-Dihydropteroic acid + Pyrophosphate
4-amino-4-deoxychorismate → Hydrogen Ion + Pyruvic acid + p-Aminobenzoic acid
Chorismate + L-Glutamine → 4-amino-4-deoxychorismate + L-Glutamic acid
Guanosine triphosphate + Water → Dihydroneopterin triphosphate + Formic acid + Hydrogen Ion
5,10-Methenyltetrahydrofolic acid + Water → 10-Formyltetrahydrofolate + Hydrogen Ion