2-Oxo-3-phenylpropanoic acid (Mixture oxo and keto)
Aromatic/aminoadipate aminotransferase 1
Multifunctional tryptophan biosynthesis protein
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
N-(5'-phosphoribosyl)anthranilate isomerase
Chorismate + L-Glutamine → 2-Aminobenzoic acid + Hydrogen Ion + L-Glutamic acid + Pyruvic acid
2-Aminobenzoic acid + Phosphoribosyl pyrophosphate → N-(5-phosphoribosyl)-anthranilate + Pyrophosphate
N-(5-phosphoribosyl)-anthranilate → 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
L-Tryptophan + Oxoglutaric acid → L-Glutamic acid + indole-3-pyruvate
2-Oxo-3-phenylpropanoic acid (Mixture oxo and keto) + L-Tryptophan → L-Phenylalanine + indole-3-pyruvate
Hydrogen Ion + indole-3-pyruvate → Carbon dioxide + Indoleacetaldehyde
Hydrogen Ion + Indoleacetaldehyde + NADH → NAD + Tryptophol
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + Hydrogen Ion → Carbon dioxide + Indoleglycerol phosphate + Water
Indoleglycerol phosphate → D-Glyceraldehyde 3-phosphate + Indole
Indole + L-Serine → L-Tryptophan + Water
L-Tryptophan → N'-Formylkynurenine + Oxygen
L-Kynurenine + Water → 2-Aminobenzoic acid + Hydrogen Ion + L-Alanine
3-Hydroxyanthranilic acid + Oxygen → 2-Amino-3-carboxymuconic acid semialdehyde + Hydrogen Ion
3-hydroxy-L-kynurenine + Water → 3-Hydroxyanthranilic acid + Hydrogen Ion + L-Alanine
Hydrogen Ion + L-Kynurenine + NADPH + Oxygen → 3-hydroxy-L-kynurenine + NADP + Water
N'-Formylkynurenine + Water → Formic acid + Hydrogen Ion + L-Kynurenine
2-Amino-3-carboxymuconic acid semialdehyde