Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/ChemSpider 96860
type: UnificationXref
id: 96860
db: ChemSpider

Homocitric acid
type: SmallMoleculeReference
xref: Reference/CAS 3562-74-1
xref: Reference/KEGG Compound C01251
xref: Reference/HMDB HMDB0003518
xref: Reference/BioCyc HOMO-CIT
xref: Reference/PubChem-compound 439459
xref: Reference/ChemSpider 388564
xref: Reference/ChEBI CHEBI 52222
chemical formula: C7H10O7
molecular weight: 206.04265
structure: ChemicalStructure/PW C001911

Reference/ChemSpider 388353
type: UnificationXref
id: 388353
db: ChemSpider

Reference/ChEBI CHEBI 30797
type: UnificationXref
id: CHEBI:30797
db: ChEBI

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

Compound/PW C001991/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-(a-Hydroxyethyl)thiamine diphosphate
stoichiometric coefficient: 1.0

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001066
type: UnificationXref
id: HMDB0001066
db: HMDB

Reference/UniProt P10963
type: UnificationXref
id: P10963
db: UniProt

Reference/ChemSpider 388368
type: UnificationXref
id: 388368
db: ChemSpider

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

Reference/CAS 3562-74-1
type: UnificationXref
id: 3562-74-1
db: CAS

Reference/KEGG Compound C02504
type: UnificationXref
id: C02504
db: KEGG Compound

Reference/UniProt P52489
type: UnificationXref
id: P52489
db: UniProt

NAD
type: SmallMolecule
entity reference: NAD

S-Lactoylglutathione
type: SmallMolecule
entity reference: S-Lactoylglutathione

Reference/BioCyc OXALACETIC ACID
type: UnificationXref
id: OXALACETIC_ACID
db: BioCyc

Compound/PW C000101/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Malic acid
stoichiometric coefficient: 1.0

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/PubChem-compound 440018
type: UnificationXref
id: 440018
db: PubChem-compound

Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
type: ProteinReference
xref: Reference/UniProt P32473

Reference/ChEBI CHEBI 978
type: UnificationXref
id: CHEBI:978
db: ChEBI

Pyruvate dehydrogenase complex protein X component, mitochondrial
type: ProteinReference
xref: Reference/UniProt P16451

Reference/ChemSpider 48
type: UnificationXref
id: 48
db: ChemSpider

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

ReactionCatalysis6466
type: Catalysis
controller: NADPH-dependent methylglyoxal reductase
controlled: 1.1.1.283,1.1.1.265
control type: ACTIVATION

Unknown
type: ProteinReference

ReactionCatalysis6469
type: Catalysis
controller: D-lactate dehydrogenase
controlled: 1.1.2.4
control type: ACTIVATION

Reference/HMDB HMDB0006880
type: UnificationXref
id: HMDB0006880
db: HMDB

ReactionCatalysis6468
type: Catalysis
controller: hydroxyacylglutathione hydrolase
controlled: 3.1.2.6
control type: ACTIVATION

ReactionCatalysis6467
type: Catalysis
controller: lactoylglutathione lyase
controlled: 4.4.1.5
control type: ACTIVATION

Reference/ChEBI CHEBI 16236
type: UnificationXref
id: CHEBI:16236
db: ChEBI

ReactionCatalysis6473
type: Catalysis
controller: phosphoenolpyruvate carboxykinase
controlled: 4.1.1.49
control type: ACTIVATION

Reference/PubChem-compound 702
type: UnificationXref
id: 702
db: PubChem-compound

ReactionCatalysis6472
type: Catalysis
controller: pyruvate carboxylase
controlled: 6.4.1.1
control type: ACTIVATION

Reference/BioCyc D-LACTATE
type: UnificationXref
id: D-LACTATE
db: BioCyc

Compound/PW C001034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

ReactionCatalysis6471
type: Catalysis
controller: Unknown
controlled: 1.1.2.3
control type: ACTIVATION

Reference/CAS 49601-06-1
type: UnificationXref
id: 49601-06-1
db: CAS

ReactionCatalysis6470
type: Catalysis
controller: pyruvate kinase
controlled: 2.7.1.40
control type: ACTIVATION

Reference/BioCyc HCO3
type: UnificationXref
id: HCO3
db: BioCyc

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Acetyl-CoA carboxylase
type: ProteinReference
xref: Reference/UniProt Q00955

Reference/KEGG Compound C00332
type: UnificationXref
id: C00332
db: KEGG Compound

Glutathione reductase
type: ProteinReference
xref: Reference/UniProt P41921

Compound/PW C000905/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvaldehyde
stoichiometric coefficient: 1.0

ReactionCatalysis6477
type: Catalysis
controller: alcohol dehydrogenase
controlled: Reaction6558
control type: ACTIVATION

Reference/CAS 154-87-0
type: UnificationXref
id: 154-87-0
db: CAS

ReactionCatalysis6476
type: Catalysis
controller: pyruvate decarboxylase
controlled: Reaction6557
control type: ACTIVATION

ReactionCatalysis6475
type: Catalysis
controller: malate dehydrogenase
controlled: Reaction6556
control type: ACTIVATION

ReactionCatalysis6474
type: Catalysis
controller: malate dehydrogenase
controlled: 1.1.1.38
control type: ACTIVATION

Reference/CAS 97-67-6
type: UnificationXref
id: 97-67-6
db: CAS

ReactionCatalysis6479
type: Catalysis
controller: Pyruvate dehydrogenase complex
controlled: Reaction6560
control type: ACTIVATION

ReactionCatalysis6478
type: Catalysis
controller: Pyruvate dehydrogenase complex
controlled: Reaction6559
control type: ACTIVATION

ReactionCatalysis6480
type: Catalysis
controller: Pyruvate dehydrogenase complex
controlled: Reaction6561
control type: ACTIVATION

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

Reference/KEGG Compound C00469
type: UnificationXref
id: C00469
db: KEGG Compound

ReactionCatalysis6484
type: Catalysis
controller: 2-isopropylmalate synthase
controlled: 2.3.3.13
control type: ACTIVATION

ReactionCatalysis6483
type: Catalysis
controller: acetyl-CoA synthetase
controlled: Reaction6564
control type: ACTIVATION

ReactionCatalysis6482
type: Catalysis
controller: acetyl-CoA synthetase
controlled: 6.2.1.1
control type: ACTIVATION

ReactionCatalysis6481
type: Catalysis
controller: acetyl-CoA hydrolase
controlled: 3.1.2.1
control type: ACTIVATION

Reference/CAS 13015-87-7
type: UnificationXref
id: 13015-87-7
db: CAS

Acetyl-CoA
type: SmallMolecule
entity reference: Acetyl-CoA

Homocitric acid
type: SmallMolecule
entity reference: Homocitric acid

Reference/ChemSpider 945
type: UnificationXref
id: 945
db: ChemSpider

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reference/CAS 10326-41-7
type: UnificationXref
id: 10326-41-7
db: CAS

Saccharomyces cerevisiae
type: BioSource
xref: Reference/TAXONOMY 4932

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Reference/UniProt P41338
type: UnificationXref
id: P41338
db: UniProt

ReactionCatalysis6487
type: Catalysis
controller: Pyruvate carboxylase, mitochondrial
controlled: Reaction6568
control type: ACTIVATION

ReactionCatalysis6486
type: Catalysis
controller: Homocitrate synthase, mitochondrial
controlled: Reaction6567
control type: ACTIVATION

ReactionCatalysis6485
type: Catalysis
controller: Acetyl-CoA acetyltransferase
controlled: 2.3.1.9
control type: ACTIVATION

Reference/CAS 138-08-9
type: UnificationXref
id: 138-08-9
db: CAS

Compound/PW C000032/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

pyruvate decarboxylase 2
type: ProteinReference
xref: Reference/UniProt P16467

alcohol dehydrogenase subunit I
type: ProteinReference
xref: Reference/UniProt P25377

Pyruvate decarboxylase isozyme 1
type: ProteinReference
xref: Reference/UniProt P06169

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

Reference/PubChem-compound 124886
type: UnificationXref
id: 124886
db: PubChem-compound

Reference/UniProt P26263
type: UnificationXref
id: P26263
db: UniProt

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

Reference/UniProt P16451
type: UnificationXref
id: P16451
db: UniProt

Compound/PW C000463/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen carbonate
stoichiometric coefficient: 1.0

Ferrocytochrome
type: SmallMolecule
entity reference: Ferrocytochrome

Pyruvate decarboxylase isozyme 3
type: ProteinReference
xref: Reference/UniProt P26263

alcohol dehydrogenase subunit 2
type: ProteinReference
xref: Reference/UniProt Q04894

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/ChEBI CHEBI 17158
type: UnificationXref
id: CHEBI:17158
db: ChEBI

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/CAS 10055-47-7
type: UnificationXref
id: 10055-47-7
db: CAS

Reference/PubChem-compound C16255
type: UnificationXref
id: C16255
db: PubChem-compound

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/ChemSpider 388564
type: UnificationXref
id: 388564
db: ChemSpider

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/ChemSpider 1031
type: UnificationXref
id: 1031
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/CAS 598-35-6
type: UnificationXref
id: 598-35-6
db: CAS

Reference/UniProt P16467
type: UnificationXref
id: P16467
db: UniProt

Protein/9972/Stoichiometry/24.0
type: Stoichiometry
physical entity: Glutathione reductase
stoichiometric coefficient: 24.0

Reference/HMDB HMDB0003052
type: UnificationXref
id: HMDB0003052
db: HMDB

ChemicalStructure/PW C000905
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)C=O

lactoylglutathione lyase
type: ProteinReference
xref: Reference/UniProt P50107

NADPH-dependent methylglyoxal reductase
type: ProteinReference
xref: Reference/UniProt Q12068

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

S-Lactoylglutathione
type: SmallMoleculeReference
xref: Reference/CAS 25138-66-3
xref: Reference/BioCyc S-LACTOYL-GLUTATHIONE
xref: Reference/KEGG Compound C03451
xref: Reference/ChemSpider 389032
xref: Reference/PubChem-compound 440018
xref: Reference/ChEBI CHEBI 15694
xref: Reference/HMDB HMDB0001066
chemical formula: C13H21N3O8S
molecular weight: 379.10495
structure: ChemicalStructure/PW C000841

Reference/PubChem-compound 107689
type: UnificationXref
id: 107689
db: PubChem-compound

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

Compound/PW C000784/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetaldehyde
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Reference/KEGG Compound C00256
type: UnificationXref
id: C00256
db: KEGG Compound

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

D-lactate dehydrogenase 3
type: ProteinReference
xref: Reference/UniProt P39976

hydroxyacylglutathione hydrolase
type: ProteinReference
xref: Reference/UniProt Q12320

hydroxyacylglutathione hydrolase
type: ProteinReference
xref: Reference/UniProt Q05584

D-lactate dehydrogenase 2
type: ProteinReference
xref: Reference/UniProt P46681

D-lactate dehydrogenase 1
type: ProteinReference
xref: Reference/UniProt P32891

Reference/CAS 25138-66-3
type: UnificationXref
id: 25138-66-3
db: CAS

pyruvate carboxylase 2
type: ProteinReference
xref: Reference/UniProt P32327

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

phosphoenolpyruvate carboxykinase
type: ProteinReference
xref: Reference/UniProt P10963

pyruvate carboxylase 1
type: ProteinReference
xref: Reference/UniProt P11154

Reference/KEGG Compound C00149
type: UnificationXref
id: C00149
db: KEGG Compound

pyruvate kinase II
type: ProteinReference
xref: Reference/UniProt P52489

pyruvate kinase I
type: ProteinReference
xref: Reference/UniProt P00549

Reference/KEGG Compound C00022
type: UnificationXref
id: C00022
db: KEGG Compound

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

Reference/KEGG Compound C00141
type: UnificationXref
id: C00141
db: KEGG Compound

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

Reference/ChEBI CHEBI 52222
type: UnificationXref
id: CHEBI:52222
db: ChEBI

ChemicalStructure/PW C000911
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc ACET
type: UnificationXref
id: ACET
db: BioCyc

Reference/UniProt P06208
type: UnificationXref
id: P06208
db: UniProt

Compound/PW C000143/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

malate dehydrogenase
type: ProteinReference
xref: Reference/UniProt P36013

Reference/BioCyc OXIDIZED-GLUTATHIONE
type: UnificationXref
id: OXIDIZED-GLUTATHIONE
db: BioCyc

Compound/PW C000080/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glutathione
stoichiometric coefficient: 1.0

Reference/PubChem-compound 769
type: UnificationXref
id: 769
db: PubChem-compound

Acetyl-CoA acetyltransferase
type: Protein
entity reference: Acetyl-CoA acetyltransferase

2-Isopropylmalic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 5280523
xref: Reference/ChemSpider 4444155
xref: Reference/HMDB HMDB0000402
xref: Reference/KEGG Compound C02504
xref: Reference/CAS 49601-06-1
xref: Reference/ChEBI CHEBI 35128
chemical formula: C7H12O5
molecular weight: 176.06847
structure: ChemicalStructure/PW C000301

Reference/UniProt P25377
type: UnificationXref
id: P25377
db: UniProt

Reference/KEGG Compound C00033
type: UnificationXref
id: C00033
db: KEGG Compound

Reference/HMDB HMDB0003518
type: UnificationXref
id: HMDB0003518
db: HMDB

Reference/KEGG Compound C00036
type: UnificationXref
id: C00036
db: KEGG Compound

Protein/Generic266/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lipoamide-E
stoichiometric coefficient: 1.0

Reference/PubChem-compound 880
type: UnificationXref
id: 880
db: PubChem-compound

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

1.1.1.283,1.1.1.265
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000905/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001765/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Pyruvaldehyde
right: NADP
right: Hydrogen Ion
spontaneous: false
EC number: 1.1.1.283,1.1.1.265
left: NADP
left: Lactaldehyde
name: Lactaldehyde + NADP ↔ Hydrogen Ion + NADP + Pyruvaldehyde
conversion direction: REVERSIBLE

4.4.1.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000080/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000905/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000841/Stoichiometry/1.0
right: S-Lactoylglutathione
spontaneous: false
EC number: 4.4.1.5
left: Pyruvaldehyde
left: Glutathione
name: Glutathione + Pyruvaldehyde ↔ S-Lactoylglutathione
conversion direction: REVERSIBLE

Water
type: SmallMolecule
entity reference: Water

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

ChemicalStructure/PW C001142
type: ChemicalStructure
structure format: SMILES

3.1.2.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001010/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000080/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000841/Stoichiometry/1.0
right: D-Lactic acid
right: Glutathione
spontaneous: false
EC number: 3.1.2.6
left: Water
left: S-Lactoylglutathione
name: S-Lactoylglutathione + Water ↔ D-Lactic acid + Glutathione
conversion direction: REVERSIBLE

Reference/KEGG Compound C01251
type: UnificationXref
id: C01251
db: KEGG Compound

Reference/HMDB HMDB0000019
type: UnificationXref
id: HMDB0000019
db: HMDB

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Lactaldehyde
type: SmallMoleculeReference
xref: Reference/CAS 598-35-6
xref: Reference/KEGG Compound C00424
xref: Reference/ChemSpider 388368
xref: Reference/PubChem-compound 439231
xref: Reference/ChEBI CHEBI 18041
xref: Reference/HMDB HMDB0003052
xref: Reference/BioCyc LACTALD
chemical formula: C3H6O2
molecular weight: 74.03678
structure: ChemicalStructure/PW C001765

Reference/ChEBI CHEBI 18041
type: UnificationXref
id: CHEBI:18041
db: ChEBI

Reference/KEGG Compound C00288
type: UnificationXref
id: C00288
db: KEGG Compound

Acetyl adenylate
type: SmallMolecule
entity reference: Acetyl adenylate

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Protein/Generic265/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Acetyldihydrolipoamide-E
stoichiometric coefficient: 1.0

Compound/PW C000170/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/UniProt P50107
type: UnificationXref
id: P50107
db: UniProt

Reference/KEGG Compound C00051
type: UnificationXref
id: C00051
db: KEGG Compound

Reference/BioCyc PHOSPHO-ENOL-PYRUVATE
type: UnificationXref
id: PHOSPHO-ENOL-PYRUVATE
db: BioCyc

Reference/ChEBI CHEBI 9532
type: UnificationXref
id: CHEBI:9532
db: ChEBI

Reference/UniProt P36013
type: UnificationXref
id: P36013
db: UniProt

2-isopropylmalate synthase LEU9
type: Protein
entity reference: 2-isopropylmalate synthase LEU9

acetyl-CoA hydrolase
type: Protein
entity reference: acetyl-CoA hydrolase

acetate--CoA ligase 1
type: Protein
entity reference: acetate--CoA ligase 1

acetate--CoA ligase ACS2
type: Protein
entity reference: acetate--CoA ligase ACS2

Reference/HMDB HMDB0000263
type: UnificationXref
id: HMDB0000263
db: HMDB

ChemicalStructure/PW C000180
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C(=C)OP(O)(O)=O

2-isopropylmalate synthase
type: Protein
entity reference: 2-isopropylmalate synthase

Reference/ChemSpider 389703
type: UnificationXref
id: 389703
db: ChemSpider

Reference/CAS 78-98-8
type: UnificationXref
id: 78-98-8
db: CAS

ChemicalStructure/PW C000029
type: ChemicalStructure
structure format: SMILES
structure data: CC(O)=O

ChemicalStructure/PW C000148
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC(=O)C(O)=O

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Compound/PW C000164/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 1.0

Lactaldehyde
type: SmallMolecule
entity reference: Lactaldehyde

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Reference/HMDB HMDB0000156
type: UnificationXref
id: HMDB0000156
db: HMDB

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

Reaction6568
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000463/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000911/Stoichiometry/1.0
right: Adenosine diphosphate
right: Pyrophosphate
right: Malonyl-CoA
spontaneous: false
left: Hydrogen carbonate
left: Acetyl-CoA
left: Adenosine triphosphate
name: Acetyl-CoA + Adenosine triphosphate + Hydrogen carbonate ↔ Adenosine diphosphate + Malonyl-CoA + Pyrophosphate
conversion direction: REVERSIBLE

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C03451
type: UnificationXref
id: C03451
db: KEGG Compound

Reaction6560
type: BiochemicalReaction
participant stoichiometry: Protein/Generic265/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001991/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001060/Stoichiometry/1.0
participant stoichiometry: Protein/Generic266/Stoichiometry/1.0
right: S-Acetyldihydrolipoamide-E
right: Thiamine pyrophosphate
spontaneous: false
left: Lipoamide-E
left: 2-(a-Hydroxyethyl)thiamine diphosphate
name: 2-(a-Hydroxyethyl)thiamine diphosphate + Lipoamide-E ↔ S-Acetyldihydrolipoamide-E + Thiamine pyrophosphate
conversion direction: REVERSIBLE

Reaction6561
type: BiochemicalReaction
participant stoichiometry: Protein/Generic265/Stoichiometry/1.0
participant stoichiometry: Protein/Generic267/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940/Stoichiometry/1.0
right: Dihydrolipoamide-E
right: Acetyl-CoA
spontaneous: false
left: Coenzyme A
left: S-Acetyldihydrolipoamide-E
name: Coenzyme A + S-Acetyldihydrolipoamide-E ↔ Acetyl-CoA + Dihydrolipoamide-E
conversion direction: REVERSIBLE

3.1.2.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000029/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940/Stoichiometry/1.0
right: Coenzyme A
right: Acetic acid
spontaneous: false
EC number: 3.1.2.1
left: Water
left: Acetyl-CoA
name: Acetyl-CoA + Water → Acetic acid + Coenzyme A
conversion direction: LEFT_TO_RIGHT

6.2.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000032/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002987/Stoichiometry/1.0
right: Coenzyme A
right: Acetyl adenylate
spontaneous: false
EC number: 6.2.1.1
left: Adenosine monophosphate
left: Acetyl-CoA
name: Acetyl-CoA + Adenosine monophosphate ↔ Acetyl adenylate + Coenzyme A
conversion direction: REVERSIBLE

Reaction6564
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000029/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002987/Stoichiometry/1.0
right: Acetic acid
right: Adenosine triphosphate
spontaneous: false
left: Pyrophosphate
left: Acetyl adenylate
name: Acetyl adenylate + Pyrophosphate ↔ Acetic acid + Adenosine triphosphate
conversion direction: REVERSIBLE

Ferrocytochrome
type: SmallMoleculeReference
xref: Reference/CAS 1818-68-4
xref: Reference/KEGG Compound C05183
xref: Reference/ChEBI CHEBI 15910
xref: Reference/HMDB HMDB0012947
chemical formula: C33H32FeN4O4
molecular weight: 604.1762
structure: ChemicalStructure/PW C008134

2.3.3.13
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000301/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000012/Stoichiometry/1.0
right: Water
right: α-Ketoisovaleric acid
right: Acetyl-CoA
spontaneous: false
EC number: 2.3.3.13
left: Coenzyme A
left: 2-Isopropylmalic acid
name: 2-Isopropylmalic acid + Coenzyme A ↔ Acetyl-CoA + Water + α-Ketoisovaleric acid
conversion direction: REVERSIBLE

2.3.1.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001142/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940/Stoichiometry/1.0
right: Coenzyme A
right: Acetoacetyl-CoA
spontaneous: false
EC number: 2.3.1.9
left: Acetyl-CoA
name: Acetyl-CoA ↔ Acetoacetyl-CoA + Coenzyme A
conversion direction: REVERSIBLE

Reference/HMDB HMDB0001484
type: UnificationXref
id: HMDB0001484
db: HMDB

Reaction6567
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001911/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940/Stoichiometry/1.0
right: Coenzyme A
right: Homocitric acid
spontaneous: false
left: Water
left: Acetyl-CoA
name: Acetyl-CoA + Water ↔ Coenzyme A + Homocitric acid
conversion direction: REVERSIBLE

Compound/PW C000029/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetic acid
stoichiometric coefficient: 1.0

Compound/PW C008134/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ferrocytochrome
stoichiometric coefficient: 1.0

Protein/Generic267/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydrolipoamide-E
stoichiometric coefficient: 1.0

ChemicalStructure/PW C040778
type: ChemicalStructure
structure format: SMILES
structure data: CCCCC

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/KEGG Compound C00186
type: UnificationXref
id: C00186
db: KEGG Compound

2-Isopropylmalic acid
type: SmallMolecule
entity reference: 2-Isopropylmalic acid

ChemicalStructure/PW C040779
type: ChemicalStructure
structure format: SMILES

Acetaldehyde
type: SmallMolecule
entity reference: Acetaldehyde

Reference/KEGG Compound C05993
type: UnificationXref
id: C05993
db: KEGG Compound

Reference/KEGG Compound C00068
type: UnificationXref
id: C00068
db: KEGG Compound

Reaction6557
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000784/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Carbon dioxide
right: Acetaldehyde
spontaneous: false
left: Hydrogen Ion
left: Pyruvic acid
name: Hydrogen Ion + Pyruvic acid → Acetaldehyde + Carbon dioxide
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000164
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)C(O)=O

Reaction6558
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000721/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000784/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000070/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: NAD
right: Ethanol
spontaneous: false
left: NADH
left: Hydrogen Ion
left: Acetaldehyde
name: Acetaldehyde + Hydrogen Ion + NADH ↔ Ethanol + NAD
conversion direction: REVERSIBLE

2-(a-Hydroxyethyl)thiamine diphosphate
type: SmallMolecule
entity reference: 2-(a-Hydroxyethyl)thiamine diphosphate

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

ChemicalStructure/PW C001010
type: ChemicalStructure
structure format: SMILES
structure data: C[C@H](O)C(O)=O

Reaction6559
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001991/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001060/Stoichiometry/1.0
right: 2-(a-Hydroxyethyl)thiamine diphosphate
right: Carbon dioxide
spontaneous: false
left: Pyruvic acid
left: Thiamine pyrophosphate
name: Pyruvic acid + Thiamine pyrophosphate → 2-(a-Hydroxyethyl)thiamine diphosphate + Carbon dioxide
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00074
type: UnificationXref
id: C00074
db: KEGG Compound

2-(a-Hydroxyethyl)thiamine diphosphate
type: SmallMoleculeReference
xref: Reference/ChemSpider 389468
xref: Reference/CAS 10055-47-7
xref: Reference/HMDB HMDB0003904
xref: Reference/KEGG Compound C05125
xref: Reference/PubChem-compound 440568
xref: Reference/ChEBI CHEBI 978
chemical formula: C14H23N4O8P2S
molecular weight: 469.0712
structure: ChemicalStructure/PW C001991

Acetaldehyde
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15343
xref: Reference/KEGG Compound C00084
xref: Reference/CAS 75-07-0
xref: Reference/BioCyc ACETALD
xref: Reference/ChemSpider 172
xref: Reference/PubChem-compound 177
xref: Reference/HMDB HMDB0000990
chemical formula: C2H4O
molecular weight: 44.026215
structure: ChemicalStructure/PW C000784

1.1.2.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001010/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040778/Stoichiometry/2.0
participant stoichiometry: Compound/PW C040779/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000164/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/2.0
right: Hydrogen Ion
right: Pyruvic acid
right: ferrocytochrome c
spontaneous: false
EC number: 1.1.2.4
left: D-Lactic acid
left: ferricytochrome c
name: D-Lactic acid + 2 ferricytochrome c → 2 Hydrogen Ion + Pyruvic acid + 2 ferrocytochrome c
conversion direction: LEFT_TO_RIGHT

2.7.1.40
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000180/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164/Stoichiometry/1.0
right: Adenosine diphosphate
right: Phosphoenolpyruvic acid
spontaneous: false
EC number: 2.7.1.40
left: Pyruvic acid
left: Adenosine triphosphate
name: Adenosine triphosphate + Pyruvic acid ↔ Adenosine diphosphate + Phosphoenolpyruvic acid
conversion direction: REVERSIBLE

1.1.2.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C008134/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000122/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040779/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Hydrogen Ion
right: Pyruvic acid
right: Ferrocytochrome
spontaneous: false
EC number: 1.1.2.3
left: L-Lactic acid
left: ferricytochrome c
name: L-Lactic acid + ferricytochrome c ? Ferrocytochrome + Hydrogen Ion + Pyruvic acid

6.4.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000463/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000148/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
right: Adenosine diphosphate
right: Oxalacetic acid
right: Phosphate
spontaneous: false
EC number: 6.4.1.1
left: Hydrogen carbonate
left: Pyruvic acid
left: Adenosine triphosphate
name: Adenosine triphosphate + Hydrogen carbonate + Pyruvic acid ↔ Adenosine diphosphate + Oxalacetic acid + Phosphate
conversion direction: REVERSIBLE

Reference/HMDB HMDB0000042
type: UnificationXref
id: HMDB0000042
db: HMDB

4.1.1.49
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000180/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000148/Stoichiometry/1.0
right: Adenosine diphosphate
right: Phosphoenolpyruvic acid
spontaneous: false
EC number: 4.1.1.49
left: Oxalacetic acid
left: Adenosine triphosphate
name: Adenosine triphosphate + Oxalacetic acid ↔ Adenosine diphosphate + Phosphoenolpyruvic acid
conversion direction: REVERSIBLE

Reference/HMDB HMDB0001372
type: UnificationXref
id: HMDB0001372
db: HMDB

1.1.1.38
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000101/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: L-Malic acid
right: NAD
spontaneous: false
EC number: 1.1.1.38
left: NADH
left: Hydrogen Ion
left: Pyruvic acid
left: Carbon dioxide
name: Carbon dioxide + Hydrogen Ion + NADH + Pyruvic acid ↔ L-Malic acid + NAD
conversion direction: REVERSIBLE

Reaction6556
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000721/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000101/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000148/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: L-Malic acid
right: NAD
spontaneous: false
left: NADH
left: Hydrogen Ion
left: Oxalacetic acid
name: Hydrogen Ion + NADH + Oxalacetic acid ↔ L-Malic acid + NAD
conversion direction: REVERSIBLE

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/UniProt P39976
type: UnificationXref
id: P39976
db: UniProt

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Reference/CAS 64-17-5
type: UnificationXref
id: 64-17-5
db: CAS

Unknown
type: Protein
entity reference: Unknown

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Reference/UniProt Q00955
type: UnificationXref
id: Q00955
db: UniProt

Reference/ChemSpider 857
type: UnificationXref
id: 857
db: ChemSpider

Reference/BioCyc LACTALD
type: UnificationXref
id: LACTALD
db: BioCyc

Phosphate
type: SmallMolecule
entity reference: Phosphate

2-isopropylmalate synthase LEU9
type: ProteinReference
xref: Reference/UniProt Q12166

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

2-isopropylmalate synthase
type: ProteinReference
xref: Reference/UniProt P06208

acetyl-CoA hydrolase
type: ProteinReference
xref: Reference/UniProt P32316

Reference/KEGG Compound C00084
type: UnificationXref
id: C00084
db: KEGG Compound

α-Ketoisovaleric acid
type: SmallMolecule
entity reference: α-Ketoisovaleric acid

acetate--CoA ligase ACS2
type: ProteinReference
xref: Reference/UniProt P52910

Reference/KEGG Compound C00083
type: UnificationXref
id: C00083
db: KEGG Compound

acetate--CoA ligase 1
type: ProteinReference
xref: Reference/UniProt Q01574

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/ChEBI CHEBI 42111
type: UnificationXref
id: CHEBI:42111
db: ChEBI

ChemicalStructure/PW C001060
type: ChemicalStructure
structure format: SMILES
structure data: CC1=C(CCOP(O)(=O)OP(O)(O)=O)SC=[N+]1CC1=CN=C(C)N=C1N

Reference/ChEBI CHEBI 44897
type: UnificationXref
id: CHEBI:44897
db: ChEBI

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/BioCyc PYRUVATE
type: UnificationXref
id: PYRUVATE
db: BioCyc

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

Protein/9971/Stoichiometry/60.0
type: Stoichiometry
physical entity: Pyruvate dehydrogenase complex protein X component, mitochondrial
stoichiometric coefficient: 60.0

Glutathione reductase
type: Protein
entity reference: Glutathione reductase

Pyruvate dehydrogenase complex protein X component, mitochondrial
type: Protein
entity reference: Pyruvate dehydrogenase complex protein X component, mitochondrial

L-Lactic acid
type: SmallMolecule
entity reference: L-Lactic acid

L-Lactic acid
type: SmallMoleculeReference
xref: Reference/CAS 79-33-4
xref: Reference/ChEBI CHEBI 422
xref: Reference/HMDB HMDB0000190
xref: Reference/PubChem-compound 107689
xref: Reference/KEGG Compound C00186
xref: Reference/BioCyc L-LACTATE
xref: Reference/ChemSpider 96860
chemical formula: C3H6O3
molecular weight: 90.03169
structure: ChemicalStructure/PW C000122

Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
type: Protein
entity reference: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

Acetyl-CoA acetyltransferase
type: ProteinReference
xref: Reference/UniProt P41338

Lipoamide-E
type: Protein
entity reference: Lipoamide-E

S-Acetyldihydrolipoamide-E
type: Protein
entity reference: S-Acetyldihydrolipoamide-E

Dihydrolipoamide-E
type: Protein
entity reference: Dihydrolipoamide-E

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Reference/TAXONOMY 4932
type: UnificationXref
id: 4932
db: TAXONOMY

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

Reference/HMDB HMDB0000190
type: UnificationXref
id: HMDB0000190
db: HMDB

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

Acetyl adenylate
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL AMP
xref: Reference/ChemSpider 389703
xref: Reference/CAS 13015-87-7
xref: Reference/ChEBI CHEBI 37666
xref: Reference/PubChem-compound 440867
xref: Reference/HMDB HMDB0006880
xref: Reference/KEGG Compound C05993
chemical formula: C12H16N5O8P
molecular weight: 389.07364
structure: ChemicalStructure/PW C002987

Reference/ChemSpider 1100
type: UnificationXref
id: 1100
db: ChemSpider

Reference/PubChem-compound 10663
type: UnificationXref
id: 10663
db: PubChem-compound

Reference/HMDB HMDB0001167
type: UnificationXref
id: HMDB0001167
db: HMDB

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/UniProt P41921
type: UnificationXref
id: P41921
db: UniProt

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Acetyl-CoA carboxylase
type: Protein
entity reference: Acetyl-CoA carboxylase

Homocitrate synthase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q12122

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

ChemicalStructure/PW C000070
type: ChemicalStructure
structure format: SMILES
structure data: CCO

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Reference/ChEBI CHEBI 15910
type: UnificationXref
id: CHEBI:15910
db: ChEBI

Carbon dioxide
type: SmallMolecule
entity reference: Carbon dioxide

Reference/ChemSpider 749
type: UnificationXref
id: 749
db: ChemSpider

Reference/CAS 71-52-3
type: UnificationXref
id: 71-52-3
db: CAS

Reference/PubChem-compound 970
type: UnificationXref
id: 970
db: PubChem-compound

L-Malic acid
type: SmallMolecule
entity reference: L-Malic acid

Reference/ChemSpider 980
type: UnificationXref
id: 980
db: ChemSpider

Hydrogen carbonate
type: SmallMolecule
entity reference: Hydrogen carbonate

ChemicalStructure/PW C000080
type: ChemicalStructure
structure format: SMILES

L-Malic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000156
xref: Reference/ChEBI CHEBI 30797
xref: Reference/KEGG Compound C00149
xref: Reference/ChemSpider 193317
xref: Reference/PubChem-compound 222656
xref: Reference/CAS 97-67-6
chemical formula: C4H6O5
molecular weight: 134.02153
structure: ChemicalStructure/PW C000101

Hydrogen carbonate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000595
xref: Reference/ChEBI CHEBI 17544
xref: Reference/PubChem-compound 769
xref: Reference/BioCyc HCO3
xref: Reference/ChemSpider 749
xref: Reference/CAS 71-52-3
xref: Reference/KEGG Compound C00288
chemical formula: CH2O3
molecular weight: 62.000393
structure: ChemicalStructure/PW C000463

Reference/HMDB HMDB0001175
type: UnificationXref
id: HMDB0001175
db: HMDB

Reference/ChemSpider 4444155
type: UnificationXref
id: 4444155
db: ChemSpider

Reference/UniProt Q12068
type: UnificationXref
id: Q12068
db: UniProt

Reference/CAS 1818-68-4
type: UnificationXref
id: 1818-68-4
db: CAS

Acetic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15366
xref: Reference/BioCyc ACET
xref: Reference/CAS 64-19-7
xref: Reference/KEGG Compound C00033
xref: Reference/ChemSpider 171
xref: Reference/HMDB HMDB0000042
xref: Reference/PubChem-compound 176
chemical formula: C2H4O2
molecular weight: 60.02113
structure: ChemicalStructure/PW C000029

Oxalacetic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000223
xref: Reference/CAS 328-42-7
xref: Reference/ChEBI CHEBI 30744
xref: Reference/BioCyc OXALACETIC ACID
xref: Reference/ChemSpider 945
xref: Reference/PubChem-compound 970
xref: Reference/KEGG Compound C00036
chemical formula: C4H4O5
molecular weight: 132.00587
structure: ChemicalStructure/PW C000148

Reference/UniProt P52910
type: UnificationXref
id: P52910
db: UniProt

ChemicalStructure/PW C002987
type: ChemicalStructure
structure format: SMILES

Compound/PW C002987/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl adenylate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1132
type: UnificationXref
id: 1132
db: PubChem-compound

NADH
type: SmallMolecule
entity reference: NADH

Reference/CAS 64-19-7
type: UnificationXref
id: 64-19-7
db: CAS

Pyruvate carboxylase, mitochondrial
type: Complex
component stoichiometry: Protein/9981/Stoichiometry/4.0
component: Acetyl-CoA carboxylase

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Acetoacetyl-CoA
type: SmallMolecule
entity reference: Acetoacetyl-CoA

Compound/PW C000301/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Isopropylmalic acid
stoichiometric coefficient: 1.0

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

Pyrophosphate
type: SmallMolecule
entity reference: Pyrophosphate

Reference/ChEBI CHEBI 16928
type: UnificationXref
id: CHEBI:16928
db: ChEBI

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Pyruvate decarboxylase isozyme 1
type: Protein
entity reference: Pyruvate decarboxylase isozyme 1

Reference/PubChem-compound 3425
type: UnificationXref
id: 3425
db: PubChem-compound

pyruvate decarboxylase 2
type: Protein
entity reference: pyruvate decarboxylase 2

alcohol dehydrogenase subunit I
type: Protein
entity reference: alcohol dehydrogenase subunit I

Reference/PubChem-compound 1005
type: UnificationXref
id: 1005
db: PubChem-compound

Pyruvate decarboxylase isozyme 3
type: Protein
entity reference: Pyruvate decarboxylase isozyme 3

alcohol dehydrogenase subunit 2
type: Protein
entity reference: alcohol dehydrogenase subunit 2

Compound/PW C001010/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Lactic acid
stoichiometric coefficient: 1.0

D-Lactic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001311
xref: Reference/ChemSpider 55423
xref: Reference/BioCyc D-LACTATE
xref: Reference/CAS 10326-41-7
xref: Reference/KEGG Compound C00256
xref: Reference/PubChem-compound 61503
xref: Reference/ChEBI CHEBI 42111
chemical formula: C3H6O3
molecular weight: 90.03169
structure: ChemicalStructure/PW C001010

Compound/PW C000414/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Compound/PW C000180/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoenolpyruvic acid
stoichiometric coefficient: 1.0

Reference/CAS 328-42-7
type: UnificationXref
id: 328-42-7
db: CAS

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

ChemicalStructure/PW C000101
type: ChemicalStructure
structure format: SMILES
structure data: O[C@@H](CC(O)=O)C(O)=O

D-Lactic acid
type: SmallMolecule
entity reference: D-Lactic acid

Pyruvic acid
type: SmallMolecule
entity reference: Pyruvic acid

ChemicalStructure/PW C000463
type: ChemicalStructure
structure format: SMILES
structure data: OC(O)=O

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Pyruvic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 1060
xref: Reference/HMDB HMDB0000243
xref: Reference/CAS 127-17-3
xref: Reference/BioCyc PYRUVATE
xref: Reference/KEGG Compound C00022
xref: Reference/ChEBI CHEBI 32816
xref: Reference/ChemSpider 1031
chemical formula: C3H4O3
molecular weight: 88.016045
structure: ChemicalStructure/PW C000164

Reference/UniProt Q12166
type: UnificationXref
id: Q12166
db: UniProt

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Compound/PW C000940/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Compound/PW C000070/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ethanol
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

ferrocytochrome c
type: SmallMolecule
entity reference: ferrocytochrome c

ferricytochrome c
type: SmallMolecule
entity reference: ferricytochrome c

Reference/CAS 759-05-7
type: UnificationXref
id: 759-05-7
db: CAS

Compound/PW C000122/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Lactic acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Adenosine monophosphate
type: SmallMolecule
entity reference: Adenosine monophosphate

α-Ketoisovaleric acid
type: SmallMoleculeReference
xref: Reference/CAS 759-05-7
xref: Reference/PubChem-compound 49
xref: Reference/ChemSpider 48
xref: Reference/HMDB HMDB0000019
xref: Reference/BioCyc 2-KETO-ISOVALERATE
xref: Reference/KEGG Compound C00141
xref: Reference/ChEBI CHEBI 16530
chemical formula: C5H8O3
molecular weight: 116.04734
structure: ChemicalStructure/PW C000012

pyruvate decarboxylase
type: Complex
component: Pyruvate decarboxylase isozyme 1
component: pyruvate decarboxylase 2
component: Pyruvate decarboxylase isozyme 3

Pyruvate Metabolism
type: Pathway
pathway order: PathwayEnzymeReaction/25339
pathway order: PathwayEnzymeReaction/25342
pathway order: PathwayEnzymeReaction/25375
pathway order: PathwayEnzymeReaction/25343
pathway order: PathwayEnzymeReaction/25376
pathway order: PathwayEnzymeReaction/25333
pathway order: PathwayEnzymeReaction/25344
pathway order: PathwayEnzymeReaction/25377
pathway order: PathwayEnzymeReaction/25334
pathway order: PathwayEnzymeReaction/25345
pathway order: PathwayEnzymeReaction/25335
pathway order: PathwayEnzymeReaction/25346
pathway order: PathwayEnzymeReaction/25336
pathway order: PathwayEnzymeReaction/25347
pathway order: PathwayEnzymeReaction/25337
pathway order: PathwayEnzymeReaction/25338
pathway order: PathwayEnzymeReaction/25371
pathway order: PathwayEnzymeReaction/25372
pathway order: PathwayEnzymeReaction/25340
pathway order: PathwayEnzymeReaction/25373
pathway order: PathwayEnzymeReaction/25341
pathway order: PathwayEnzymeReaction/25374
pathway component: ReactionCatalysis6473
pathway component: ReactionCatalysis6472
pathway component: ReactionCatalysis6471
pathway component: ReactionCatalysis6470
pathway component: Reaction6568
pathway component: 1.1.1.283,1.1.1.265
pathway component: 4.4.1.5
pathway component: 3.1.2.6
pathway component: ReactionCatalysis6477
pathway component: Reaction6560
pathway component: ReactionCatalysis6476
pathway component: Reaction6561
pathway component: ReactionCatalysis6475
pathway component: 3.1.2.1
pathway component: ReactionCatalysis6474
pathway component: 6.2.1.1
pathway component: Reaction6564
pathway component: 2.3.3.13
pathway component: ReactionCatalysis6479
pathway component: 2.3.1.9
pathway component: ReactionCatalysis6478
pathway component: Reaction6567
pathway component: ReactionCatalysis6480
pathway component: ReactionCatalysis6484
pathway component: ReactionCatalysis6483
pathway component: ReactionCatalysis6482
pathway component: ReactionCatalysis6481
pathway component: Reaction6557
pathway component: Reaction6558
pathway component: Reaction6559
pathway component: ReactionCatalysis6466
pathway component: 1.1.2.4
pathway component: ReactionCatalysis6487
pathway component: 2.7.1.40
pathway component: ReactionCatalysis6486
pathway component: 1.1.2.3
pathway component: ReactionCatalysis6485
pathway component: 6.4.1.1
pathway component: ReactionCatalysis6469
pathway component: 4.1.1.49
pathway component: ReactionCatalysis6468
pathway component: 1.1.1.38
pathway component: ReactionCatalysis6467
pathway component: Reaction6556
xref: Reference/PathWhiz PW002447
xref: Reference/SMPDB SMP0002355
organism: Saccharomyces cerevisiae

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Reference/ChemSpider 55423
type: UnificationXref
id: 55423
db: ChemSpider

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Oxalacetic acid
type: SmallMolecule
entity reference: Oxalacetic acid

ChemicalStructure/PW C001765
type: ChemicalStructure
structure format: SMILES
structure data: C[C@H](O)C=O

Acetic acid
type: SmallMolecule
entity reference: Acetic acid

NADP
type: SmallMolecule
entity reference: NADP

Reference/BioCyc 2-KETO-ISOVALERATE
type: UnificationXref
id: 2-KETO-ISOVALERATE
db: BioCyc

Reference/UniProt P11154
type: UnificationXref
id: P11154
db: UniProt

Reference/BioCyc L-LACTATE
type: UnificationXref
id: L-LACTATE
db: BioCyc

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

Compound/PW C000012/Stoichiometry/1.0
type: Stoichiometry
physical entity: α-Ketoisovaleric acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16856
type: UnificationXref
id: CHEBI:16856
db: ChEBI

Reference/PubChem-compound C15972
type: UnificationXref
id: C15972
db: PubChem-compound

Reference/PubChem-compound C15973
type: UnificationXref
id: C15973
db: PubChem-compound

Reference/PubChem-compound 440867
type: UnificationXref
id: 440867
db: PubChem-compound

Reference/KEGG Compound C05125
type: UnificationXref
id: C05125
db: KEGG Compound

Reference/BioCyc ETOH
type: UnificationXref
id: ETOH
db: BioCyc

Reference/BioCyc S-LACTOYL-GLUTATHIONE
type: UnificationXref
id: S-LACTOYL-GLUTATHIONE
db: BioCyc

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Ethanol
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00469
xref: Reference/ChEBI CHEBI 16236
xref: Reference/PubChem-compound 702
xref: Reference/ChemSpider 682
xref: Reference/HMDB HMDB0000108
xref: Reference/CAS 64-17-5
xref: Reference/BioCyc ETOH
chemical formula: C2H6O
molecular weight: 46.041866
structure: ChemicalStructure/PW C000070

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

ChemicalStructure/PW C000012
type: ChemicalStructure
structure format: SMILES
structure data: CC(C)C(=O)C(O)=O

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Compound/PW C000841/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Lactoylglutathione
stoichiometric coefficient: 1.0

Thiamine pyrophosphate
type: SmallMolecule
entity reference: Thiamine pyrophosphate

Reference/ChEBI CHEBI 15531
type: UnificationXref
id: CHEBI:15531
db: ChEBI

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/UniProt Q05584
type: UnificationXref
id: Q05584
db: UniProt

Reference/ChEBI CHEBI 37666
type: UnificationXref
id: CHEBI:37666
db: ChEBI

Reference/ChEBI CHEBI 35128
type: UnificationXref
id: CHEBI:35128
db: ChEBI

Reference/UniProt P46681
type: UnificationXref
id: P46681
db: UniProt

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0001311
type: UnificationXref
id: HMDB0001311
db: HMDB

Glutathione
type: SmallMoleculeReference
xref: Reference/CAS 70-18-8
xref: Reference/HMDB HMDB0000125
xref: Reference/BioCyc OXIDIZED-GLUTATHIONE
xref: Reference/KEGG Compound C00051
xref: Reference/ChEBI CHEBI 16856
xref: Reference/PubChem-compound 124886
xref: Reference/ChemSpider 111188
chemical formula: C10H17N3O6S
molecular weight: 307.0838
structure: ChemicalStructure/PW C000080

Reference/HMDB HMDB0000223
type: UnificationXref
id: HMDB0000223
db: HMDB

Reference/ChemSpider 682
type: UnificationXref
id: 682
db: ChemSpider

Reference/SMPDB SMP0002355
type: UnificationXref
id: SMP0002355
db: SMPDB

Glutathione
type: SmallMolecule
entity reference: Glutathione

Reference/PubChem-compound 49
type: UnificationXref
id: 49
db: PubChem-compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Reference/HMDB HMDB0000108
type: UnificationXref
id: HMDB0000108
db: HMDB

Reference/HMDB HMDB0000595
type: UnificationXref
id: HMDB0000595
db: HMDB

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

Acetoacetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETOACETYL-COA
xref: Reference/PubChem-compound 439214
xref: Reference/ChEBI CHEBI 15345
xref: Reference/CAS 1420-36-6
xref: Reference/HMDB HMDB0001484
xref: Reference/KEGG Compound C00332
xref: Reference/ChemSpider 388353
chemical formula: C25H40N7O18P3S
molecular weight: 851.13635
structure: ChemicalStructure/PW C001142

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

Ethanol
type: SmallMolecule
entity reference: Ethanol

Homocitrate synthase, mitochondrial
type: Protein
entity reference: Homocitrate synthase, mitochondrial

Reference/ChEBI CHEBI 15991
type: UnificationXref
id: CHEBI:15991
db: ChEBI

Reference/HMDB HMDB0000243
type: UnificationXref
id: HMDB0000243
db: HMDB

Adenosine diphosphate
type: SmallMolecule
entity reference: Adenosine diphosphate

Reference/HMDB HMDB0000125
type: UnificationXref
id: HMDB0000125
db: HMDB

Phosphoenolpyruvic acid
type: SmallMoleculeReference
xref: Reference/CAS 138-08-9
xref: Reference/ChEBI CHEBI 44897
xref: Reference/KEGG Compound C00074
xref: Reference/BioCyc PHOSPHO-ENOL-PYRUVATE
xref: Reference/ChemSpider 980
xref: Reference/PubChem-compound 1005
xref: Reference/HMDB HMDB0000263
chemical formula: C3H5O6P
molecular weight: 167.98238
structure: ChemicalStructure/PW C000180

Pyruvate dehydrogenase complex
type: Complex
component stoichiometry: Protein/9971/Stoichiometry/60.0
component stoichiometry: Protein/9970/Stoichiometry/60.0
component stoichiometry: Protein/9969/Stoichiometry/60.0
component stoichiometry: Protein/9972/Stoichiometry/24.0
component: Glutathione reductase
component: Pyruvate dehydrogenase complex protein X component, mitochondrial
component: Unknown
component: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/BioCyc ACETYL AMP
type: UnificationXref
id: ACETYL_AMP
db: BioCyc

ChemicalStructure/PW C000122
type: ChemicalStructure
structure format: SMILES
structure data: C[C@H](O)C(O)=O

Compound/PW C000911/Stoichiometry/1.0
type: Stoichiometry
physical entity: Malonyl-CoA
stoichiometric coefficient: 1.0

Phosphoenolpyruvic acid
type: SmallMolecule
entity reference: Phosphoenolpyruvic acid

Reference/CAS 70-18-8
type: UnificationXref
id: 70-18-8
db: CAS

Compound/PW C000721/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000841
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 16530
type: UnificationXref
id: CHEBI:16530
db: ChEBI

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Reference/PubChem-compound 5280523
type: UnificationXref
id: 5280523
db: PubChem-compound

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

Reference/BioCyc METHYL-GLYOXAL
type: UnificationXref
id: METHYL-GLYOXAL
db: BioCyc

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/BioCyc 2-(alpha-lactyl)-thpp
type: UnificationXref
id: 2-(alpha-lactyl)-thpp
db: BioCyc

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Reference/PubChem-compound 222656
type: UnificationXref
id: 222656
db: PubChem-compound

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

Reference/ChEBI CHEBI 15694
type: UnificationXref
id: CHEBI:15694
db: ChEBI

Coenzyme A
type: SmallMolecule
entity reference: Coenzyme A

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Reference/KEGG Compound C05183
type: UnificationXref
id: C05183
db: KEGG Compound

Reference/ChemSpider 10213
type: UnificationXref
id: 10213
db: ChemSpider

Reference/UniProt Q12320
type: UnificationXref
id: Q12320
db: UniProt

Reference/BioCyc ACETOACETYL-COA
type: UnificationXref
id: ACETOACETYL-COA
db: BioCyc

Compound/PW C001142/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetoacetyl-CoA
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

ChemicalStructure/PW C001911
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC[C@@](O)(CC(O)=O)C(O)=O

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

Reference/CAS 524-14-1
type: UnificationXref
id: 524-14-1
db: CAS

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Reference/PubChem-compound 440568
type: UnificationXref
id: 440568
db: PubChem-compound

Reference/CAS 79-33-4
type: UnificationXref
id: 79-33-4
db: CAS

Reference/CAS 127-17-3
type: UnificationXref
id: 127-17-3
db: CAS

Compound/PW C001316/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/PubChem-compound 439214
type: UnificationXref
id: 439214
db: PubChem-compound

Reference/PubChem-compound 439459
type: UnificationXref
id: 439459
db: PubChem-compound

Thiamine pyrophosphate
type: SmallMoleculeReference
xref: Reference/BioCyc 2-(alpha-lactyl)-thpp
xref: Reference/ChEBI CHEBI 9532
xref: Reference/CAS 154-87-0
xref: Reference/ChemSpider 1100
xref: Reference/HMDB HMDB0001372
xref: Reference/PubChem-compound 1132
xref: Reference/KEGG Compound C00068
chemical formula: C12H19N4O7P2S
molecular weight: 425.04498
structure: ChemicalStructure/PW C001060

Compound/PW C001099/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Lipoamide-E
type: ProteinReference
xref: Reference/PubChem-compound C15972

Reference/ChemSpider 389032
type: UnificationXref
id: 389032
db: ChemSpider

Dihydrolipoamide-E
type: ProteinReference
xref: Reference/PubChem-compound C15973

Compound/PW C001144/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Reference/UniProt P00549
type: UnificationXref
id: P00549
db: UniProt

Reference/UniProt Q01574
type: UnificationXref
id: Q01574
db: UniProt

Protein/9981/Stoichiometry/4.0
type: Stoichiometry
physical entity: Acetyl-CoA carboxylase
stoichiometric coefficient: 4.0

Reference/UniProt P32473
type: UnificationXref
id: P32473
db: UniProt

Reference/ChEBI CHEBI 15366
type: UnificationXref
id: CHEBI:15366
db: ChEBI

Reference/PathWhiz PW002447
type: UnificationXref
id: PW002447
db: PathWhiz

Reference/ChEBI CHEBI 17544
type: UnificationXref
id: CHEBI:17544
db: ChEBI

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

acetyl-CoA synthetase
type: Complex
component: acetate--CoA ligase 1
component: acetate--CoA ligase ACS2

2-isopropylmalate synthase
type: Complex
component: 2-isopropylmalate synthase LEU9
component: 2-isopropylmalate synthase

Pyruvaldehyde
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001167
xref: Reference/KEGG Compound C00546
xref: Reference/ChEBI CHEBI 17158
xref: Reference/CAS 78-98-8
xref: Reference/BioCyc METHYL-GLYOXAL
xref: Reference/ChemSpider 857
xref: Reference/PubChem-compound 880
chemical formula: C3H4O2
molecular weight: 72.021126
structure: ChemicalStructure/PW C000905

Compound/PW C001104/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

pyruvate kinase
type: Complex
component: pyruvate kinase I
component: pyruvate kinase II

pyruvate carboxylase
type: Complex
component: pyruvate carboxylase 2
component: pyruvate carboxylase 1

Reference/PubChem-compound 439231
type: UnificationXref
id: 439231
db: PubChem-compound

hydroxyacylglutathione hydrolase
type: Complex
component: hydroxyacylglutathione hydrolase

D-lactate dehydrogenase
type: Complex
component: D-lactate dehydrogenase 1
component: D-lactate dehydrogenase 2
component: D-lactate dehydrogenase 3

Protein/9969/Stoichiometry/60.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 60.0

Reference/CAS 75-07-0
type: UnificationXref
id: 75-07-0
db: CAS

S-Acetyldihydrolipoamide-E
type: ProteinReference
xref: Reference/PubChem-compound C16255

Reference/HMDB HMDB0012947
type: UnificationXref
id: HMDB0012947
db: HMDB

Reference/ChemSpider 172
type: UnificationXref
id: 172
db: ChemSpider

ChemicalStructure/PW C008134
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 171
type: UnificationXref
id: 171
db: ChemSpider

Compound/PW C001765/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lactaldehyde
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 32816
type: UnificationXref
id: CHEBI:32816
db: ChEBI

Reference/CAS 1420-36-6
type: UnificationXref
id: 1420-36-6
db: CAS

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Malonyl-CoA
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15531
xref: Reference/KEGG Compound C00083
xref: Reference/BioCyc MALONYL-COA
xref: Reference/CAS 524-14-1
xref: Reference/HMDB HMDB0001175
xref: Reference/PubChem-compound 10663
xref: Reference/ChemSpider 10213
chemical formula: C24H38N7O19P3S
molecular weight: 853.1156
structure: ChemicalStructure/PW C000911

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/BioCyc ACETALD
type: UnificationXref
id: ACETALD
db: BioCyc

ferrocytochrome c
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 16928
chemical formula: C5H12
molecular weight: 72.0939
structure: ChemicalStructure/PW C040778

ferricytochrome c
type: SmallMoleculeReference
xref: Reference/PubChem-compound 3425
xref: Reference/ChEBI CHEBI 15991
chemical formula: C42H68O13
molecular weight: 780.466
structure: ChemicalStructure/PW C040779

Compound/PW C040779/Stoichiometry/2.0
type: Stoichiometry
physical entity: ferricytochrome c
stoichiometric coefficient: 2.0

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Compound/PW C001060/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thiamine pyrophosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001991
type: ChemicalStructure
structure format: SMILES

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 422
type: UnificationXref
id: CHEBI:422
db: ChEBI

Protein/9970/Stoichiometry/60.0
type: Stoichiometry
physical entity: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
stoichiometric coefficient: 60.0

ChemicalStructure/PW C000301
type: ChemicalStructure
structure format: SMILES
structure data: CC(C)[C@@](O)(CC(O)=O)C(O)=O

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

ChemicalStructure/PW C000784
type: ChemicalStructure
structure format: SMILES
structure data: CC=O

Compound/PW C040778/Stoichiometry/2.0
type: Stoichiometry
physical entity: ferrocytochrome c
stoichiometric coefficient: 2.0

Reference/ChEBI CHEBI 30744
type: UnificationXref
id: CHEBI:30744
db: ChEBI

Reference/UniProt P32891
type: UnificationXref
id: P32891
db: UniProt

Reference/ChemSpider 111188
type: UnificationXref
id: 111188
db: ChemSpider

Reference/BioCyc HOMO-CIT
type: UnificationXref
id: HOMO-CIT
db: BioCyc

Reference/PubChem-compound 61503
type: UnificationXref
id: 61503
db: PubChem-compound

Reference/ChEBI CHEBI 15343
type: UnificationXref
id: CHEBI:15343
db: ChEBI

Reference/UniProt Q12122
type: UnificationXref
id: Q12122
db: UniProt

Reference/ChemSpider 389468
type: UnificationXref
id: 389468
db: ChemSpider

Reference/UniProt P32327
type: UnificationXref
id: P32327
db: UniProt

Reference/ChEBI CHEBI 15345
type: UnificationXref
id: CHEBI:15345
db: ChEBI

pyruvate carboxylase 2
type: Protein
entity reference: pyruvate carboxylase 2

pyruvate carboxylase 1
type: Protein
entity reference: pyruvate carboxylase 1

phosphoenolpyruvate carboxykinase
type: Protein
entity reference: phosphoenolpyruvate carboxykinase

malate dehydrogenase
type: Protein
entity reference: malate dehydrogenase

pyruvate kinase I
type: Protein
entity reference: pyruvate kinase I

Malonyl-CoA
type: SmallMolecule
entity reference: Malonyl-CoA

pyruvate kinase II
type: Protein
entity reference: pyruvate kinase II

Compound/PW C001911/Stoichiometry/1.0
type: Stoichiometry
physical entity: Homocitric acid
stoichiometric coefficient: 1.0

Reference/UniProt Q04894
type: UnificationXref
id: Q04894
db: UniProt

Reference/ChemSpider 193317
type: UnificationXref
id: 193317
db: ChemSpider

Compound/PW C000148/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxalacetic acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000990
type: UnificationXref
id: HMDB0000990
db: HMDB

Compound/PW C040034/Stoichiometry/2.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 2.0

Pyruvaldehyde
type: SmallMolecule
entity reference: Pyruvaldehyde

Reference/PubChem-compound 1060
type: UnificationXref
id: 1060
db: PubChem-compound

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/KEGG Compound C00546
type: UnificationXref
id: C00546
db: KEGG Compound

Reference/KEGG Compound C00424
type: UnificationXref
id: C00424
db: KEGG Compound

Reference/UniProt P32316
type: UnificationXref
id: P32316
db: UniProt

hydroxyacylglutathione hydrolase
type: Protein
entity reference: hydroxyacylglutathione hydrolase

D-lactate dehydrogenase 1
type: Protein
entity reference: D-lactate dehydrogenase 1

D-lactate dehydrogenase 2
type: Protein
entity reference: D-lactate dehydrogenase 2

D-lactate dehydrogenase 3
type: Protein
entity reference: D-lactate dehydrogenase 3

Reference/UniProt P06169
type: UnificationXref
id: P06169
db: UniProt

Compound/PW C040779/Stoichiometry/1.0
type: Stoichiometry
physical entity: ferricytochrome c
stoichiometric coefficient: 1.0

NADPH-dependent methylglyoxal reductase
type: Protein
entity reference: NADPH-dependent methylglyoxal reductase

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

lactoylglutathione lyase
type: Protein
entity reference: lactoylglutathione lyase

hydroxyacylglutathione hydrolase
type: Protein
entity reference: hydroxyacylglutathione hydrolase

Reference/HMDB HMDB0003904
type: UnificationXref
id: HMDB0003904
db: HMDB

Reference/PubChem-compound 177
type: UnificationXref
id: 177
db: PubChem-compound

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

Reference/PubChem-compound 176
type: UnificationXref
id: 176
db: PubChem-compound

Reference/HMDB HMDB0000402
type: UnificationXref
id: HMDB0000402
db: HMDB

alcohol dehydrogenase
type: Complex
component: alcohol dehydrogenase subunit I
component: alcohol dehydrogenase subunit 2

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

Reference/BioCyc MALONYL-COA
type: UnificationXref
id: MALONYL-COA
db: BioCyc