Reference/ChemSpider 141370
type: UnificationXref
id: 141370
db: ChemSpider

Reference/CAS 454-29-5
type: UnificationXref
id: 454-29-5
db: CAS

Compound/PW C040845/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
stoichiometric coefficient: 1.0

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Compound/PW C001178/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5,10-Methylene-THF
stoichiometric coefficient: 1.0

Folate Biosynthesis
type: Pathway
xref: Reference/PathWhiz PW122419
xref: Reference/SMPDB SMP0121139
name: ActivatingSubPathway

dihydrofolate reductase
type: ProteinReference
xref: Reference/UniProt P07807

Reference/CAS 365-07-1
type: UnificationXref
id: 365-07-1
db: CAS

FAICAR
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 18381
chemical formula: C10H15N4O9P
molecular weight: 366.05768
structure: ChemicalStructure/PW C040844

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 18406
chemical formula: C9H15N4O8P
molecular weight: 338.06274
structure: ChemicalStructure/PW C040845

Reference/CAS 964-26-1
type: UnificationXref
id: 964-26-1
db: CAS

Compound/PW C001556/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5'-phosphoribosyl-a-N-formylglycineamidine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16134
type: UnificationXref
id: CHEBI:16134
db: ChEBI

Compound/PW C041668/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-Amino-4-deoxy-L-arabinose
stoichiometric coefficient: 1.0

Reference/KEGG Compound C05330
type: UnificationXref
id: C05330
db: KEGG Compound

UDP-L-Ara4N formyltransferase / UDP-GlcA C-4"-decarboxylase
type: Complex
component stoichiometry: Protein/9969/Stoichiometry/6.0
component: Unknown

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Ammonia
type: SmallMoleculeReference
xref: Reference/BioCyc AMMONIA
xref: Reference/CAS 7664-41-7
xref: Reference/HMDB HMDB0000051
xref: Reference/PubChem-compound 222
xref: Reference/KEGG Compound C00014
xref: Reference/ChEBI CHEBI 16134
xref: Reference/ChemSpider 217
chemical formula: H3N
molecular weight: 17.026548
structure: ChemicalStructure/PW C000035

Reference/CAS 58-05-9
type: UnificationXref
id: 58-05-9
db: CAS

Reference/BioCyc 10-FORMYL-THF
type: UnificationXref
id: 10-FORMYL-THF
db: BioCyc

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/KEGG Compound C03838
type: UnificationXref
id: C03838
db: KEGG Compound

Reaction179458
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000774/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001199/Stoichiometry/1.0
right: N5-Formyl-THF
spontaneous: false
left: 10-Formyltetrahydrofolate
name: 10-Formyltetrahydrofolate → N5-Formyl-THF
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 20506
type: UnificationXref
id: CHEBI:20506
db: ChEBI

Reference/ChEBI CHEBI 17115
type: UnificationXref
id: CHEBI:17115
db: ChEBI

Reference/CAS 7444-29-3
type: UnificationXref
id: 7444-29-3
db: CAS

Dihydrofolic acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00415
xref: Reference/BioCyc DIHYDROFOLATE
xref: Reference/ChEBI CHEBI 15633
xref: Reference/ChemSpider 89228
xref: Reference/PubChem-compound 98792
xref: Reference/HMDB HMDB0001056
xref: Reference/CAS 4033-27-6
chemical formula: C19H21N7O6
molecular weight: 443.15533
structure: ChemicalStructure/PW C000831

5-Thymidylic acid
type: SmallMoleculeReference
xref: Reference/BioCyc TMP
xref: Reference/PubChem-compound 9700
xref: Reference/HMDB HMDB0001227
xref: Reference/ChemSpider 9319
xref: Reference/CAS 365-07-1
xref: Reference/KEGG Compound C00364
xref: Reference/ChEBI CHEBI 17013
chemical formula: C10H15N2O8P
molecular weight: 322.0566
structure: ChemicalStructure/PW C000950

Reference/ChEBI CHEBI 17119
type: UnificationXref
id: CHEBI:17119
db: ChEBI

Reference/KEGG Compound C00440
type: UnificationXref
id: C00440
db: KEGG Compound

Reference/ChEBI CHEBI 17230
type: UnificationXref
id: CHEBI:17230
db: ChEBI

5'-Phosphoribosyl-N-formylglycinamide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001308
xref: Reference/CAS 349-34-8
xref: Reference/PubChem-compound 130805
xref: Reference/ChemSpider 115687
xref: Reference/KEGG Compound C04376
xref: Reference/BioCyc 5-P-RIBOSYL-N-FORMYLGLYCINEAMIDE
chemical formula: C8H15N2O9P
molecular weight: 314.0515
structure: ChemicalStructure/PW C001007

S-Aminomethyldihydrolipoylprotein;
type: ProteinReference

Reference/PubChem-compound 6137
type: UnificationXref
id: 6137
db: PubChem-compound

Reference/KEGG Compound C00445
type: UnificationXref
id: C00445
db: KEGG Compound

ChemicalStructure/PW C040918
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc 5-P-RIBOSYL-N-FORMYLGLYCINEAMIDE
type: UnificationXref
id: 5-P-RIBOSYL-N-FORMYLGLYCINEAMIDE
db: BioCyc

Reference/BioCyc 5-METHYL-THF
type: UnificationXref
id: 5-METHYL-THF
db: BioCyc

Reference/ChemSpider 18714427
type: UnificationXref
id: 18714427
db: ChemSpider

Compound/PW C001355/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glycineamideribotide
stoichiometric coefficient: 1.0

Compound/PW C001007/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5'-Phosphoribosyl-N-formylglycinamide
stoichiometric coefficient: 1.0

SubPathwayControl110030
type: Interaction
name: ActivatingSubPathwayControl
name: SubPathway110030Control
participant: Folate Biosynthesis
participant: Dihydrofolic acid

Unknown
type: ProteinReference

Reference/PubChem-compound 49791978
type: UnificationXref
id: 49791978
db: PubChem-compound

Compound/PW C000035/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonia
stoichiometric coefficient: 1.0

Reference/PathWhiz PW002468
type: UnificationXref
id: PW002468
db: PathWhiz

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

ChemicalStructure/PW C042665
type: ChemicalStructure
structure format: SMILES

Dihydrofolic acid
type: SmallMolecule
entity reference: Dihydrofolic acid
name: SubPathwayActivator

5-Thymidylic acid
type: SmallMolecule
entity reference: 5-Thymidylic acid

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/KEGG Compound C04376
type: UnificationXref
id: C04376
db: KEGG Compound

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

ChemicalStructure/PW C000548
type: ChemicalStructure
structure format: SMILES
structure data: CSCC[C@H](N)C(O)=O

5'-Phosphoribosyl-N-formylglycinamide
type: SmallMolecule
entity reference: 5'-Phosphoribosyl-N-formylglycinamide

Reference/PubChem-compound 143
type: UnificationXref
id: 143
db: PubChem-compound

ChemicalStructure/PW C001087
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 278
type: UnificationXref
id: 278
db: ChemSpider

Tetrahydrofolic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 20506
xref: Reference/ChemSpider 18714427
xref: Reference/HMDB HMDB0001846
xref: Reference/PubChem-compound 13781857
xref: Reference/BioCyc THF
xref: Reference/CAS 135-16-0
xref: Reference/KEGG Compound C00101
chemical formula: C19H23N7O6
molecular weight: 445.171
structure: ChemicalStructure/PW C001221

Ammonia
type: SmallMolecule
entity reference: Ammonia

Reference/PubChem-compound 439175
type: UnificationXref
id: 439175
db: PubChem-compound

Reference/BioCyc DUMP
type: UnificationXref
id: DUMP
db: BioCyc

Reference/ChemSpider 5736
type: UnificationXref
id: 5736
db: ChemSpider

Reference/BioCyc METHYLENE-THF
type: UnificationXref
id: METHYLENE-THF
db: BioCyc

Reference/HMDB HMDB0001409
type: UnificationXref
id: HMDB0001409
db: HMDB

NADPH
type: SmallMolecule
entity reference: NADPH

Compound/PW C042665/Stoichiometry/1.0
type: Stoichiometry
physical entity: UDP-4-Deoxy-4-formamido-β-L-arabinose
stoichiometric coefficient: 1.0

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reference/BioCyc SER
type: UnificationXref
id: SER
db: BioCyc

Reference/PubChem-compound 6037
type: UnificationXref
id: 6037
db: PubChem-compound

Reference/KEGG Compound C00101
type: UnificationXref
id: C00101
db: KEGG Compound

Reference/ChemSpider 149
type: UnificationXref
id: 149
db: ChemSpider

Saccharomyces cerevisiae
type: BioSource
xref: Reference/TAXONOMY 4932

One Carbon Pool by Folate I
type: Pathway
pathway order: PathwayEnzymeReaction/25614
pathway order: PathwayEnzymeReaction/25625
pathway order: PathwayEnzymeReaction/25615
pathway order: PathwayEnzymeReaction/25616
pathway order: PathwayEnzymeReaction/25627
pathway order: PathwayEnzymeReaction/25617
pathway order: PathwayEnzymeReaction/25628
pathway order: PathwayEnzymeReaction/25618
pathway order: PathwayEnzymeReaction/25619
pathway order: PathwaySubPathway/110030
pathway order: PathwayEnzymeReaction/25620
pathway order: PathwayEnzymeReaction/25621
pathway order: PathwayEnzymeReaction/25622
pathway order: PathwayEnzymeReaction/25612
pathway order: PathwayEnzymeReaction/25623
pathway order: PathwayEnzymeReaction/25613
pathway order: PathwayEnzymeReaction/2123881
pathway order: PathwayEnzymeReaction/2124208
pathway order: PathwayEnzymeReaction/2124207
pathway component: ReactionCatalysis169548
pathway component: 2.1.2.10
pathway component: Reaction6691
pathway component: ReactionCatalysis6639
pathway component: ReactionCatalysis6638
pathway component: ReactionCatalysis6637
pathway component: ReactionCatalysis6636
pathway component: 2.1.2.1
pathway component: Reaction6682
pathway component: ReactionCatalysis6652
pathway component: 2.1.2.-
pathway component: ReactionCatalysis6651
pathway component: 3.5.1.10
pathway component: 2.1.2.9
pathway component: Reaction179458
pathway component: ReactionCatalysis169518
pathway component: 1.3.1.71
pathway component: 2.1.1.13
pathway component: Reaction179670
pathway component: 2.1.1.45
pathway component: 1.5.1.20
pathway component: ReactionCatalysis6649
pathway component: ReactionCatalysis6647
pathway component: SubPathwayControl110030
pathway component: ReactionCatalysis6642
pathway component: ReactionCatalysis6641
pathway component: ReactionCatalysis6640
pathway component: ReactionCatalysis6646
pathway component: 1.5.1.3
pathway component: ReactionCatalysis6645
pathway component: ReactionCatalysis6644
pathway component: ReactionCatalysis6643
xref: Reference/PathWhiz PW002468
xref: Reference/SMPDB SMP0002369
organism: Saccharomyces cerevisiae

Reference/HMDB HMDB0001533
type: UnificationXref
id: HMDB0001533
db: HMDB

Compound/PW C000092/Stoichiometry/1.0
type: Stoichiometry
physical entity: Formic acid
stoichiometric coefficient: 1.0

Reference/CAS 10074-18-7
type: UnificationXref
id: 10074-18-7
db: CAS

Glycineamideribotide
type: SmallMolecule
entity reference: Glycineamideribotide

NADP
type: SmallMolecule
entity reference: NADP

Glycineamideribotide
type: SmallMoleculeReference
xref: Reference/KEGG Compound C03838
xref: Reference/ChemSpider 141370
xref: Reference/ChEBI CHEBI 18349
xref: Reference/CAS 10074-18-7
xref: Reference/PubChem-compound 160913
xref: Reference/BioCyc 5-PHOSPHO-RIBOSYL-GLYCINEAMIDE
xref: Reference/HMDB HMDB0002022
chemical formula: C7H15N2O8P
molecular weight: 286.0566
structure: ChemicalStructure/PW C001355

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

Reference/ChemSpider 140
type: UnificationXref
id: 140
db: ChemSpider

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

Reference/BioCyc THF
type: UnificationXref
id: THF
db: BioCyc

Protein/Generic202/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Aminomethyldihydrolipoylprotein;
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15641
type: UnificationXref
id: CHEBI:15641
db: ChEBI

Compound/PW C000146/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Reference/BioCyc GLY
type: UnificationXref
id: GLY
db: BioCyc

S-Aminomethyldihydrolipoylprotein;
type: Protein
entity reference: S-Aminomethyldihydrolipoylprotein;

UDP-4-Deoxy-4-formamido-β-L-arabinose
type: SmallMoleculeReference
chemical formula: C15H23N3O16P2
molecular weight: 563.05536
structure: ChemicalStructure/PW C042665

Reference/UniProt P38009
type: UnificationXref
id: P38009
db: UniProt

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

10-Formyltetrahydrofolate
type: SmallMolecule
entity reference: 10-Formyltetrahydrofolate

Reference/KEGG Compound C00234
type: UnificationXref
id: C00234
db: KEGG Compound

Compound/PW C001199/Stoichiometry/1.0
type: Stoichiometry
physical entity: N5-Formyl-THF
stoichiometric coefficient: 1.0

Reference/ChemSpider 217
type: UnificationXref
id: 217
db: ChemSpider

Reference/BioCyc 5-FORMYL-THF
type: UnificationXref
id: 5-FORMYL-THF
db: BioCyc

ChemicalStructure/PW C001221
type: ChemicalStructure
structure format: SMILES

RNA/17/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Methionyl-tRNA(Met)
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000696
type: UnificationXref
id: HMDB0000696
db: HMDB

5,10-Methenyltetrahydrofolic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001354
xref: Reference/CAS 7444-29-3
xref: Reference/BioCyc 5,10-methenyl-thf
xref: Reference/ChEBI CHEBI 15636
xref: Reference/PubChem-compound 644350
xref: Reference/ChemSpider 559356
xref: Reference/KEGG Compound C00445
chemical formula: C20H21N7O6
molecular weight: 455.15533
structure: ChemicalStructure/PW C001045

Compound/PW C001221/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tetrahydrofolic acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Reference/PubChem-compound 122347
type: UnificationXref
id: 122347
db: PubChem-compound

Reference/ChEBI CHEBI 15637
type: UnificationXref
id: CHEBI:15637
db: ChEBI

ReactionCatalysis6652
type: Catalysis
controller: UDP-L-Ara4N formyltransferase / UDP-GlcA C-4"-decarboxylase
controlled: Reaction6691
control type: ACTIVATION

Glycine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000123
xref: Reference/BioCyc GLY
xref: Reference/ChemSpider 730
xref: Reference/PubChem-compound 5257127
xref: Reference/CAS 56-40-6
xref: Reference/ChEBI CHEBI 15428
xref: Reference/KEGG Compound C00037
chemical formula: C2H5NO2
molecular weight: 75.03203
structure: ChemicalStructure/PW C000078

Compound/PW C001045/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5,10-Methenyltetrahydrofolic acid
stoichiometric coefficient: 1.0

ReactionCatalysis6651
type: Catalysis
controller: Aminomethyltransferase, mitochondrial
controlled: 2.1.2.10
control type: ACTIVATION

Folic acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00504
xref: Reference/BioCyc FOLATE
xref: Reference/ChemSpider 5815
xref: Reference/CAS 59-30-3
xref: Reference/ChEBI CHEBI 27470
xref: Reference/HMDB HMDB0000121
xref: Reference/PubChem-compound 6037
chemical formula: C19H19N7O6
molecular weight: 441.13968
structure: ChemicalStructure/PW C000076

Protein/9969/Stoichiometry/6.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 6.0

Formic acid
type: SmallMolecule
entity reference: Formic acid

Aminomethyltransferase, mitochondrial
type: Protein
entity reference: Aminomethyltransferase, mitochondrial

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/ChemSpider 9319
type: UnificationXref
id: 9319
db: ChemSpider

Reference/UniProt P06785
type: UnificationXref
id: P06785
db: UniProt

Reference/KEGG Compound C00364
type: UnificationXref
id: C00364
db: KEGG Compound

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/HMDB HMDB0001308
type: UnificationXref
id: HMDB0001308
db: HMDB

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/CAS 135-16-0
type: UnificationXref
id: 135-16-0
db: CAS

Reference/ChemSpider 388320
type: UnificationXref
id: 388320
db: ChemSpider

Reference/KEGG Compound C00365
type: UnificationXref
id: C00365
db: KEGG Compound

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

5,10-Methylene-THF
type: SmallMolecule
entity reference: 5,10-Methylene-THF

Reference/PubChem-compound 5257127
type: UnificationXref
id: 5257127
db: PubChem-compound

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

5,10-Methylene-THF
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001533
xref: Reference/CAS 3432-99-3
xref: Reference/PubChem-compound 439175
xref: Reference/ChEBI CHEBI 15636
xref: Reference/KEGG Compound C00143
xref: Reference/BioCyc METHYLENE-THF
xref: Reference/ChemSpider 388320
chemical formula: C20H23N7O6
molecular weight: 457.171
structure: ChemicalStructure/PW C001178

ChemicalStructure/PW C001355
type: ChemicalStructure
structure format: SMILES

Reference/CAS 7664-41-7
type: UnificationXref
id: 7664-41-7
db: CAS

Protein/Generic174/Stoichiometry/1.0
type: Stoichiometry
physical entity: dihydrolipoylprotein
stoichiometric coefficient: 1.0

Compound/PW C000120/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Serine
stoichiometric coefficient: 1.0

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Compound/PW C000146/Stoichiometry/2.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 2.0

Compound/PW C000590/Stoichiometry/1.0
type: Stoichiometry
physical entity: Homocysteine
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001556
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5951
type: UnificationXref
id: 5951
db: PubChem-compound

Reference/PubChem-compound 222
type: UnificationXref
id: 222
db: PubChem-compound

Compound/PW C000076/Stoichiometry/1.0
type: Stoichiometry
physical entity: Folic acid
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00014
type: UnificationXref
id: C00014
db: KEGG Compound

5,10-Methenyltetrahydrofolic acid
type: SmallMolecule
entity reference: 5,10-Methenyltetrahydrofolic acid

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Glycine
type: SmallMolecule
entity reference: Glycine

Folic acid
type: SmallMolecule
entity reference: Folic acid

Reference/SMPDB SMP0002369
type: UnificationXref
id: SMP0002369
db: SMPDB

Compound/PW C000831/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydrofolic acid
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000590
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCS)C(O)=O

Reference/HMDB HMDB0001562
type: UnificationXref
id: HMDB0001562
db: HMDB

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/ChEBI CHEBI 18349
type: UnificationXref
id: CHEBI:18349
db: ChEBI

ChemicalStructure/PW C041668
type: ChemicalStructure
structure format: SMILES

Thymidylate synthase
type: Protein
entity reference: Thymidylate synthase

Reference/ChEBI CHEBI 15633
type: UnificationXref
id: CHEBI:15633
db: ChEBI

Reference/ChEBI CHEBI 15636
type: UnificationXref
id: CHEBI:15636
db: ChEBI

Reference/ChemSpider 58574
type: UnificationXref
id: 58574
db: ChemSpider

Compound/PW C040844/Stoichiometry/1.0
type: Stoichiometry
physical entity: FAICAR
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00143
type: UnificationXref
id: C00143
db: KEGG Compound

Reference/BioCyc MET
type: UnificationXref
id: MET
db: BioCyc

Reference/UniProt P21264
type: UnificationXref
id: P21264
db: UniProt

Reference/ChEBI CHEBI 17013
type: UnificationXref
id: CHEBI:17013
db: ChEBI

FAICAR
type: SmallMolecule
entity reference: FAICAR

1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
type: SmallMolecule
entity reference: 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide

Reference/HMDB HMDB0000123
type: UnificationXref
id: HMDB0000123
db: HMDB

ChemicalStructure/PW C000120
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CO)C(O)=O

Reference/CAS 3432-99-3
type: UnificationXref
id: 3432-99-3
db: CAS

Reference/HMDB HMDB0002305
type: UnificationXref
id: HMDB0002305
db: HMDB

Compound/PW C000143/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Bifunctional purine biosynthesis protein ADE17
type: Protein
entity reference: Bifunctional purine biosynthesis protein ADE17

Phosphoribosylaminoimidazole carboxylase
type: Protein
entity reference: Phosphoribosylaminoimidazole carboxylase

Reference/HMDB HMDB0000121
type: UnificationXref
id: HMDB0000121
db: HMDB

Reference/ChEBI CHEBI 17622
type: UnificationXref
id: CHEBI:17622
db: ChEBI

L-Methionine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000696
xref: Reference/ChEBI CHEBI 16643
xref: Reference/KEGG Compound C00073
xref: Reference/CAS 63-68-3
xref: Reference/BioCyc MET
xref: Reference/PubChem-compound 6137
xref: Reference/ChemSpider 5907
chemical formula: C5H11NO2S
molecular weight: 149.05106
structure: ChemicalStructure/PW C000548

Compound/PW C000143/Stoichiometry/2.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 2.0

Compound/PW C000078/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glycine
stoichiometric coefficient: 1.0

Compound/PW C000774/Stoichiometry/1.0
type: Stoichiometry
physical entity: 10-Formyltetrahydrofolate
stoichiometric coefficient: 1.0

Reference/PathWhiz PW122419
type: UnificationXref
id: PW122419
db: PathWhiz

Reference/UniProt P48015
type: UnificationXref
id: P48015
db: UniProt

Compound/PW C000950/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Thymidylic acid
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00037
type: UnificationXref
id: C00037
db: KEGG Compound

Reference/KEGG Compound C03541
type: UnificationXref
id: C03541
db: KEGG Compound

dUMP
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17622
xref: Reference/ChemSpider 58574
xref: Reference/HMDB HMDB0001409
xref: Reference/CAS 964-26-1
xref: Reference/BioCyc DUMP
xref: Reference/PubChem-compound 65063
xref: Reference/KEGG Compound C00365
chemical formula: C9H13N2O8P
molecular weight: 308.04095
structure: ChemicalStructure/PW C001087

Water
type: SmallMolecule
entity reference: Water

Reference/HMDB HMDB0001227
type: UnificationXref
id: HMDB0001227
db: HMDB

Aminomethyltransferase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P48015

Reference/PubChem-compound 98792
type: UnificationXref
id: 98792
db: PubChem-compound

L-Methionyl-tRNA(Met)
type: RnaReference
xref: Reference/ChEBI CHEBI 16635

N-formylmethionyl-tRNA(fMet)
type: RnaReference
xref: Reference/ChEBI CHEBI 17119

4-Amino-4-deoxy-L-arabinose
type: SmallMoleculeReference
xref: Reference/PubChem-compound 17756769
chemical formula: C14H23N3O15P2
molecular weight: 535.0604
structure: ChemicalStructure/PW C041668

Reference/PubChem-compound 644350
type: UnificationXref
id: 644350
db: PubChem-compound

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/PubChem-compound 65063
type: UnificationXref
id: 65063
db: PubChem-compound

Reference/KEGG Compound C04640
type: UnificationXref
id: C04640
db: KEGG Compound

Reference/BioCyc DIHYDROFOLATE
type: UnificationXref
id: DIHYDROFOLATE
db: BioCyc

Reference/HMDB HMDB0001354
type: UnificationXref
id: HMDB0001354
db: HMDB

Compound/PW C040918/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tetrahydrofolate
stoichiometric coefficient: 1.0

dihydrolipoylprotein
type: ProteinReference

Reference/PubChem-compound 18971002
type: UnificationXref
id: 18971002
db: PubChem-compound

Reference/HMDB HMDB0000142
type: UnificationXref
id: HMDB0000142
db: HMDB

Reference/ChEBI CHEBI 16635
type: UnificationXref
id: CHEBI:16635
db: ChEBI

ReactionCatalysis169548
type: Catalysis
controller: Unknown
controlled: Reaction179670
control type: ACTIVATION

2.1.2.10
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001178/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001221/Stoichiometry/1.0
participant stoichiometry: Protein/Generic202/Stoichiometry/1.0
participant stoichiometry: Protein/Generic174/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035/Stoichiometry/1.0
right: 5,10-Methylene-THF
right: Ammonia
right: dihydrolipoylprotein
spontaneous: false
EC number: 2.1.2.10
left: Tetrahydrofolic acid
left: S-Aminomethyldihydrolipoylprotein;
name: S-Aminomethyldihydrolipoylprotein; + Tetrahydrofolic acid ↔ 5,10-Methylene-THF + Ammonia + dihydrolipoylprotein
conversion direction: REVERSIBLE

Reaction6691
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040918/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000774/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042665/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041668/Stoichiometry/1.0
right: UDP-4-Deoxy-4-formamido-β-L-arabinose
right: Tetrahydrofolate
spontaneous: false
left: 10-Formyltetrahydrofolate
left: 4-Amino-4-deoxy-L-arabinose
name: 10-Formyltetrahydrofolate + 4-Amino-4-deoxy-L-arabinose → Tetrahydrofolate + UDP-4-Deoxy-4-formamido-β-L-arabinose
conversion direction: LEFT_TO_RIGHT

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/KEGG Compound C00058
type: UnificationXref
id: C00058
db: KEGG Compound

ReactionCatalysis6639
type: Catalysis
controller: Thymidylate synthase
controlled: 2.1.1.45
control type: ACTIVATION

ReactionCatalysis6638
type: Catalysis
controller: dihydrofolate reductase
controlled: 1.5.1.3
control type: ACTIVATION

ReactionCatalysis6637
type: Catalysis
controller: dihydrofolate reductase
controlled: 1.5.1.3
control type: ACTIVATION

Formic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 30751
xref: Reference/ChemSpider 278
xref: Reference/PubChem-compound 18971002
xref: Reference/BioCyc FORMATE
xref: Reference/CAS 64-18-6
xref: Reference/KEGG Compound C00058
xref: Reference/HMDB HMDB0000142
chemical formula: CH2O2
molecular weight: 46.005478
structure: ChemicalStructure/PW C000092

ReactionCatalysis6636
type: Catalysis
controller: dihydrofolate reductase
controlled: 1.5.1.3
control type: ACTIVATION

ChemicalStructure/PW C000950
type: ChemicalStructure
structure format: SMILES

Compound/PW C001079/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Methyltetrahydrofolic acid
stoichiometric coefficient: 1.0

Reference/BioCyc AMMONIA
type: UnificationXref
id: AMMONIA
db: BioCyc

ChemicalStructure/PW C000035
type: ChemicalStructure
structure format: SMILES
structure data: N

dUMP
type: SmallMolecule
entity reference: dUMP

2.1.2.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001178/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000078/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001221/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000120/Stoichiometry/1.0
right: 5,10-Methylene-THF
right: Water
right: Glycine
spontaneous: false
EC number: 2.1.2.1
left: Tetrahydrofolic acid
left: L-Serine
name: L-Serine + Tetrahydrofolic acid ↔ 5,10-Methylene-THF + Glycine + Water
conversion direction: REVERSIBLE

Reference/CAS 63-68-3
type: UnificationXref
id: 63-68-3
db: CAS

Reaction6682
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040845/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001221/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040844/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000774/Stoichiometry/1.0
right: 10-Formyltetrahydrofolate
right: 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
spontaneous: false
left: Tetrahydrofolic acid
left: FAICAR
name: FAICAR + Tetrahydrofolic acid → 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide + 10-Formyltetrahydrofolate
conversion direction: LEFT_TO_RIGHT

2.1.2.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001355/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001221/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001007/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000774/Stoichiometry/1.0
right: Glycineamideribotide
right: 10-Formyltetrahydrofolate
spontaneous: false
EC number: 2.1.2.-
left: Tetrahydrofolic acid
left: 5'-Phosphoribosyl-N-formylglycinamide
name: 5'-Phosphoribosyl-N-formylglycinamide + Tetrahydrofolic acid → 10-Formyltetrahydrofolate + Glycineamideribotide
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc FORMATE
type: UnificationXref
id: FORMATE
db: BioCyc

3.5.1.10
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000092/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001221/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000774/Stoichiometry/1.0
right: Water
right: 10-Formyltetrahydrofolate
spontaneous: false
EC number: 3.5.1.10
left: Tetrahydrofolic acid
left: Formic acid
name: Formic acid + Tetrahydrofolic acid → 10-Formyltetrahydrofolate + Water
conversion direction: LEFT_TO_RIGHT

2.1.2.9
type: BiochemicalReaction
participant stoichiometry: RNA/17/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001221/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000774/Stoichiometry/1.0
participant stoichiometry: RNA/18/Stoichiometry/1.0
right: 10-Formyltetrahydrofolate
right: L-Methionyl-tRNA(Met)
spontaneous: false
EC number: 2.1.2.9
left: Tetrahydrofolic acid
left: N-formylmethionyl-tRNA(fMet)
name: N-formylmethionyl-tRNA(fMet) + Tetrahydrofolic acid ? 10-Formyltetrahydrofolate + L-Methionyl-tRNA(Met)

2.1.2.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001355/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001221/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001045/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001556/Stoichiometry/1.0
right: 5,10-Methenyltetrahydrofolic acid
right: Water
right: Glycineamideribotide
spontaneous: false
EC number: 2.1.2.-
left: Tetrahydrofolic acid
left: 5'-phosphoribosyl-a-N-formylglycineamidine
name: 5'-phosphoribosyl-a-N-formylglycineamidine + Tetrahydrofolic acid → 5,10-Methenyltetrahydrofolic acid + Glycineamideribotide + Water
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 5907
type: UnificationXref
id: 5907
db: ChemSpider

2.1.2.10
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001045/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001199/Stoichiometry/1.0
right: N5-Formyl-THF
spontaneous: false
EC number: 2.1.2.10
left: 5,10-Methenyltetrahydrofolic acid
left: Water
name: 5,10-Methenyltetrahydrofolic acid + Water → N5-Formyl-THF
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00504
type: UnificationXref
id: C00504
db: KEGG Compound

UDP-4-Deoxy-4-formamido-β-L-arabinose
type: SmallMolecule
entity reference: UDP-4-Deoxy-4-formamido-β-L-arabinose

Reference/PubChem-compound 9700
type: UnificationXref
id: 9700
db: PubChem-compound

Reference/ChEBI CHEBI 16643
type: UnificationXref
id: CHEBI:16643
db: ChEBI

1.3.1.71
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001178/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001045/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143/Stoichiometry/1.0
right: 5,10-Methylene-THF
right: NADP
spontaneous: false
EC number: 1.3.1.71
left: 5,10-Methenyltetrahydrofolic acid
left: NADPH
name: 5,10-Methenyltetrahydrofolic acid + NADPH → 5,10-Methylene-THF + NADP
conversion direction: LEFT_TO_RIGHT

2.1.1.13
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000548/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001079/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001221/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000590/Stoichiometry/1.0
right: Tetrahydrofolic acid
right: L-Methionine
spontaneous: false
EC number: 2.1.1.13
left: 5-Methyltetrahydrofolic acid
left: Homocysteine
name: 5-Methyltetrahydrofolic acid + Homocysteine → L-Methionine + Tetrahydrofolic acid
conversion direction: LEFT_TO_RIGHT

10-Formyltetrahydrofolate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000972
xref: Reference/PubChem-compound 122347
xref: Reference/ChemSpider 109092
xref: Reference/ChEBI CHEBI 15637
xref: Reference/CAS 2800-34-2
xref: Reference/BioCyc 10-FORMYL-THF
xref: Reference/KEGG Compound C00234
chemical formula: C20H23N7O7
molecular weight: 473.1659
structure: ChemicalStructure/PW C000774

Reference/CAS 349-34-8
type: UnificationXref
id: 349-34-8
db: CAS

Reference/CAS 56-40-6
type: UnificationXref
id: 56-40-6
db: CAS

ChemicalStructure/PW C000831
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00065
type: UnificationXref
id: C00065
db: KEGG Compound

ChemicalStructure/PW C001007
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc 5-PHOSPHO-RIBOSYL-GLYCINEAMIDE
type: UnificationXref
id: 5-PHOSPHO-RIBOSYL-GLYCINEAMIDE
db: BioCyc

Reference/CAS 2800-34-2
type: UnificationXref
id: 2800-34-2
db: CAS

L-Methionine
type: SmallMolecule
entity reference: L-Methionine

Reference/CAS 4033-27-6
type: UnificationXref
id: 4033-27-6
db: CAS

2.1.1.45
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001178/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000831/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000950/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001087/Stoichiometry/1.0
right: 5,10-Methylene-THF
right: dUMP
spontaneous: false
EC number: 2.1.1.45
left: Dihydrofolic acid
left: 5-Thymidylic acid
name: 5-Thymidylic acid + Dihydrofolic acid → 5,10-Methylene-THF + dUMP
conversion direction: LEFT_TO_RIGHT

Tetrahydrofolate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C03541
chemical formula: C19H23N7O6
molecular weight: 445.171
structure: ChemicalStructure/PW C040918

1.5.1.20
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001178/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001079/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: 5-Methyltetrahydrofolic acid
right: NADP
spontaneous: false
EC number: 1.5.1.20
left: 5,10-Methylene-THF
left: Hydrogen Ion
left: NADPH
name: 5,10-Methylene-THF + Hydrogen Ion + NADPH → 5-Methyltetrahydrofolic acid + NADP
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis6649
type: Catalysis
controller: Aminomethyltransferase, mitochondrial
controlled: 2.1.2.10
control type: ACTIVATION

N5-Formyl-THF
type: SmallMolecule
entity reference: N5-Formyl-THF

5-Methyltetrahydrofolic acid
type: SmallMolecule
entity reference: 5-Methyltetrahydrofolic acid

ReactionCatalysis6647
type: Catalysis
controller: Phosphoribosylaminoimidazole carboxylase
controlled: 2.1.2.-
control type: ACTIVATION

Compound/PW C000548/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Methionine
stoichiometric coefficient: 1.0

N5-Formyl-THF
type: SmallMoleculeReference
xref: Reference/KEGG Compound C03479
xref: Reference/ChemSpider 140
xref: Reference/CAS 58-05-9
xref: Reference/HMDB HMDB0001562
xref: Reference/BioCyc 5-FORMYL-THF
xref: Reference/PubChem-compound 143
xref: Reference/ChEBI CHEBI 209153
chemical formula: C20H23N7O7
molecular weight: 473.1659
structure: ChemicalStructure/PW C001199

5-Methyltetrahydrofolic acid
type: SmallMoleculeReference
xref: Reference/BioCyc 5-METHYL-THF
xref: Reference/ChEBI CHEBI 15641
xref: Reference/PubChem-compound 439234
xref: Reference/CAS 134-35-0
xref: Reference/KEGG Compound C00440
xref: Reference/ChemSpider 388371
xref: Reference/HMDB HMDB0001396
chemical formula: C20H25N7O6
molecular weight: 459.18665
structure: ChemicalStructure/PW C001079

Reference/KEGG Compound C00073
type: UnificationXref
id: C00073
db: KEGG Compound

Reference/ChEBI CHEBI 18381
type: UnificationXref
id: CHEBI:18381
db: ChEBI

Tetrahydrofolate
type: SmallMolecule
entity reference: Tetrahydrofolate

ReactionCatalysis6642
type: Catalysis
controller: Unknown
controlled: 2.1.2.1
control type: ACTIVATION

ReactionCatalysis6641
type: Catalysis
controller: Unknown
controlled: 2.1.1.13
control type: ACTIVATION

Reference/ChEBI CHEBI 15428
type: UnificationXref
id: CHEBI:15428
db: ChEBI

ReactionCatalysis6640
type: Catalysis
controller: Unknown
controlled: 1.5.1.20
control type: ACTIVATION

Reference/ChemSpider 115687
type: UnificationXref
id: 115687
db: ChemSpider

RNA/18/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-formylmethionyl-tRNA(fMet)
stoichiometric coefficient: 1.0

ReactionCatalysis6646
type: Catalysis
controller: Unknown
controlled: 2.1.2.9
control type: ACTIVATION

1.5.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000831/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000076/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Hydrogen Ion
right: Folic acid
right: NADPH
spontaneous: false
EC number: 1.5.1.3
left: NADP
left: Dihydrofolic acid
name: Dihydrofolic acid + NADP → Folic acid + Hydrogen Ion + NADPH
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis6645
type: Catalysis
controller: Unknown
controlled: 3.5.1.10
control type: ACTIVATION

1.5.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001221/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000831/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Tetrahydrofolic acid
right: NADP
spontaneous: false
EC number: 1.5.1.3
left: Hydrogen Ion
left: Dihydrofolic acid
left: NADPH
name: Dihydrofolic acid + Hydrogen Ion + NADPH → NADP + Tetrahydrofolic acid
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis6644
type: Catalysis
controller: Phosphoribosylaminoimidazole carboxylase
controlled: 2.1.2.-
control type: ACTIVATION

1.5.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000143/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001221/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000076/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/2.0
right: Tetrahydrofolic acid
right: NADP
spontaneous: false
EC number: 1.5.1.3
left: Hydrogen Ion
left: Folic acid
left: NADPH
name: Folic acid + 2 Hydrogen Ion + 2 NADPH → 2 NADP + Tetrahydrofolic acid
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis6643
type: Catalysis
controller: Bifunctional purine biosynthesis protein ADE17
controlled: Reaction6682
control type: ACTIVATION

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/PubChem-compound 130805
type: UnificationXref
id: 130805
db: PubChem-compound

5'-phosphoribosyl-a-N-formylglycineamidine
type: SmallMoleculeReference
xref: Reference/ChemSpider 149
xref: Reference/HMDB HMDB0002305
xref: Reference/KEGG Compound C04640
xref: Reference/PubChem-compound 154
chemical formula: C8H16N3O8P
molecular weight: 313.0675
structure: ChemicalStructure/PW C001556

Unknown
type: Protein
entity reference: Unknown

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Tetrahydrofolic acid
type: SmallMolecule
entity reference: Tetrahydrofolic acid

Reference/PubChem-compound 439234
type: UnificationXref
id: 439234
db: PubChem-compound

Reference/ChemSpider 730
type: UnificationXref
id: 730
db: ChemSpider

Reference/HMDB HMDB0000972
type: UnificationXref
id: HMDB0000972
db: HMDB

Reference/ChEBI CHEBI 30751
type: UnificationXref
id: CHEBI:30751
db: ChEBI

ChemicalStructure/PW C000774
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 27470
type: UnificationXref
id: CHEBI:27470
db: ChEBI

Reference/HMDB HMDB0000051
type: UnificationXref
id: HMDB0000051
db: HMDB

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Homocysteine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C05330
xref: Reference/CAS 454-29-5
xref: Reference/HMDB HMDB0000742
xref: Reference/ChEBI CHEBI 17230
xref: Reference/ChemSpider 757
xref: Reference/PubChem-compound 49791978
xref: Reference/BioCyc HOMO-CYS
chemical formula: C4H9NO2S
molecular weight: 135.0354
structure: ChemicalStructure/PW C000590

ChemicalStructure/PW C000092
type: ChemicalStructure
structure format: SMILES
structure data: OC=O

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/BioCyc TMP
type: UnificationXref
id: TMP
db: BioCyc

ReactionCatalysis169518
type: Catalysis
controller: Unknown
controlled: 1.3.1.71
control type: ACTIVATION

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/BioCyc 5,10-methenyl-thf
type: UnificationXref
id: 5,10-methenyl-thf
db: BioCyc

Reference/ChEBI CHEBI 18406
type: UnificationXref
id: CHEBI:18406
db: ChEBI

Reference/CAS 56-45-1
type: UnificationXref
id: 56-45-1
db: CAS

Reference/KEGG Compound C03479
type: UnificationXref
id: C03479
db: KEGG Compound

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

dihydrolipoylprotein
type: Protein
entity reference: dihydrolipoylprotein

dihydrofolate reductase
type: Protein
entity reference: dihydrofolate reductase

Reference/BioCyc HOMO-CYS
type: UnificationXref
id: HOMO-CYS
db: BioCyc

Reference/PubChem-compound 154
type: UnificationXref
id: 154
db: PubChem-compound

Reference/ChEBI CHEBI 209153
type: UnificationXref
id: CHEBI:209153
db: ChEBI

ChemicalStructure/PW C001199
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc FOLATE
type: UnificationXref
id: FOLATE
db: BioCyc

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000742
type: UnificationXref
id: HMDB0000742
db: HMDB

ChemicalStructure/PW C001079
type: ChemicalStructure
structure format: SMILES

L-Serine
type: SmallMolecule
entity reference: L-Serine

L-Serine
type: SmallMoleculeReference
xref: Reference/ChemSpider 5736
xref: Reference/ChEBI CHEBI 17115
xref: Reference/CAS 56-45-1
xref: Reference/KEGG Compound C00065
xref: Reference/PubChem-compound 5951
xref: Reference/HMDB HMDB0000187
xref: Reference/BioCyc SER
chemical formula: C3H7NO3
molecular weight: 105.042595
structure: ChemicalStructure/PW C000120

Reference/HMDB HMDB0000187
type: UnificationXref
id: HMDB0000187
db: HMDB

Compound/PW C001087/Stoichiometry/1.0
type: Stoichiometry
physical entity: dUMP
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001396
type: UnificationXref
id: HMDB0001396
db: HMDB

Reference/KEGG Compound C00415
type: UnificationXref
id: C00415
db: KEGG Compound

Reference/TAXONOMY 4932
type: UnificationXref
id: 4932
db: TAXONOMY

ChemicalStructure/PW C040844
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 160913
type: UnificationXref
id: 160913
db: PubChem-compound

Reference/ChemSpider 89228
type: UnificationXref
id: 89228
db: ChemSpider

N-formylmethionyl-tRNA(fMet)
type: Rna
entity reference: N-formylmethionyl-tRNA(fMet)

Reference/ChemSpider 388371
type: UnificationXref
id: 388371
db: ChemSpider

ChemicalStructure/PW C040845
type: ChemicalStructure
structure format: SMILES

Reference/CAS 64-18-6
type: UnificationXref
id: 64-18-6
db: CAS

L-Methionyl-tRNA(Met)
type: Rna
entity reference: L-Methionyl-tRNA(Met)

Reference/PubChem-compound 17756769
type: UnificationXref
id: 17756769
db: PubChem-compound

4-Amino-4-deoxy-L-arabinose
type: SmallMolecule
entity reference: 4-Amino-4-deoxy-L-arabinose

Reference/ChemSpider 757
type: UnificationXref
id: 757
db: ChemSpider

ChemicalStructure/PW C001045
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000076
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Homocysteine
type: SmallMolecule
entity reference: Homocysteine

Bifunctional purine biosynthesis protein ADE17
type: ProteinReference
xref: Reference/UniProt P38009

Thymidylate synthase
type: ProteinReference
xref: Reference/UniProt P06785

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

ChemicalStructure/PW C000078
type: ChemicalStructure
structure format: SMILES
structure data: NCC(O)=O

Phosphoribosylaminoimidazole carboxylase
type: ProteinReference
xref: Reference/UniProt P21264

Reference/UniProt P07807
type: UnificationXref
id: P07807
db: UniProt

Reference/SMPDB SMP0121139
type: UnificationXref
id: SMP0121139
db: SMPDB

Compound/PW C040034/Stoichiometry/2.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 2.0

Reference/ChemSpider 5815
type: UnificationXref
id: 5815
db: ChemSpider

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Reference/ChemSpider 109092
type: UnificationXref
id: 109092
db: ChemSpider

Reference/ChemSpider 559356
type: UnificationXref
id: 559356
db: ChemSpider

Reaction179670
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000774/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001045/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: 5,10-Methenyltetrahydrofolic acid
right: Water
spontaneous: false
left: Hydrogen Ion
left: 10-Formyltetrahydrofolate
name: 10-Formyltetrahydrofolate + Hydrogen Ion ↔ 5,10-Methenyltetrahydrofolic acid + Water
conversion direction: REVERSIBLE

Reference/HMDB HMDB0001846
type: UnificationXref
id: HMDB0001846
db: HMDB

5'-phosphoribosyl-a-N-formylglycineamidine
type: SmallMolecule
entity reference: 5'-phosphoribosyl-a-N-formylglycineamidine

ChemicalStructure/PW C001178
type: ChemicalStructure
structure format: SMILES

Reference/CAS 134-35-0
type: UnificationXref
id: 134-35-0
db: CAS

Reference/PubChem-compound 13781857
type: UnificationXref
id: 13781857
db: PubChem-compound

Reference/CAS 59-30-3
type: UnificationXref
id: 59-30-3
db: CAS

Reference/HMDB HMDB0001056
type: UnificationXref
id: HMDB0001056
db: HMDB

Reference/HMDB HMDB0002022
type: UnificationXref
id: HMDB0002022
db: HMDB