cystathionine beta-lyase
type: Protein
entity reference: cystathionine beta-lyase

cystathionine beta-lyase subunit 2
type: Protein
entity reference: cystathionine beta-lyase subunit 2

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Acetic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15366
xref: Reference/BioCyc ACET
xref: Reference/CAS 64-19-7
xref: Reference/KEGG Compound C00033
xref: Reference/ChemSpider 171
xref: Reference/HMDB HMDB0000042
xref: Reference/PubChem-compound 176
chemical formula: C2H4O2
molecular weight: 60.02113
structure: ChemicalStructure/PW C000029

Selenocysteine
type: SmallMolecule
entity reference: Selenocysteine

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/KEGG Compound C05689
type: UnificationXref
id: C05689
db: KEGG Compound

Reference/ChEBI CHEBI 16134
type: UnificationXref
id: CHEBI:16134
db: ChEBI

Reference/KEGG Compound C05688
type: UnificationXref
id: C05688
db: KEGG Compound

Succinic acid
type: SmallMolecule
entity reference: Succinic acid

Reference/CAS 64-19-7
type: UnificationXref
id: 64-19-7
db: CAS

Reference/ChemSpider 57
type: UnificationXref
id: 57
db: ChemSpider

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Ammonia
type: SmallMoleculeReference
xref: Reference/BioCyc AMMONIA
xref: Reference/CAS 7664-41-7
xref: Reference/HMDB HMDB0000051
xref: Reference/PubChem-compound 222
xref: Reference/KEGG Compound C00014
xref: Reference/ChEBI CHEBI 16134
xref: Reference/ChemSpider 217
chemical formula: H3N
molecular weight: 17.026548
structure: ChemicalStructure/PW C000035

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

Pyrophosphate
type: SmallMolecule
entity reference: Pyrophosphate

Acetylhomoserine
type: SmallMolecule
entity reference: Acetylhomoserine

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Compound/PW C002064/Stoichiometry/1.0
type: Stoichiometry
physical entity: Se-Methylselenocysteine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/PathWhiz PW002472
type: UnificationXref
id: PW002472
db: PathWhiz

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/KEGG Compound C04489
type: UnificationXref
id: C04489
db: KEGG Compound

Reference/KEGG Compound C05699
type: UnificationXref
id: C05699
db: KEGG Compound

Reference/KEGG Compound C05335
type: UnificationXref
id: C05335
db: KEGG Compound

Reference/KEGG Compound C05698
type: UnificationXref
id: C05698
db: KEGG Compound

Compound/PW C000414/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Pyruvic acid
type: SmallMolecule
entity reference: Pyruvic acid

Reference/PubChem-compound 58
type: UnificationXref
id: 58
db: PubChem-compound

Pyruvic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 1060
xref: Reference/HMDB HMDB0000243
xref: Reference/CAS 127-17-3
xref: Reference/BioCyc PYRUVATE
xref: Reference/KEGG Compound C00022
xref: Reference/ChEBI CHEBI 32816
xref: Reference/ChemSpider 1031
chemical formula: C3H4O3
molecular weight: 88.016045
structure: ChemicalStructure/PW C000164

Compound/PW C000035/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonia
stoichiometric coefficient: 1.0

Compound/PW C002727/Stoichiometry/1.0
type: Stoichiometry
physical entity: Selenocystathionine
stoichiometric coefficient: 1.0

Compound/PW C002066/Stoichiometry/1.0
type: Stoichiometry
physical entity: Selenohomocysteine
stoichiometric coefficient: 1.0

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

ChemicalStructure/PW C040920
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCOC(=O)CCC(O)=O)C(O)=O

ChemicalStructure/PW C002727
type: ChemicalStructure
structure format: SMILES
structure data: NC(CC[Se]CC(N)C(O)=O)C(O)=O

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

tRNA(Met)
type: Rna
entity reference: tRNA(Met)

Reference/ChEBI CHEBI 9100
type: UnificationXref
id: CHEBI:9100
db: ChEBI

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/ChemSpider 88693
type: UnificationXref
id: 88693
db: ChemSpider

Reference/KEGG Compound C04144
type: UnificationXref
id: C04144
db: KEGG Compound

Ammonia
type: SmallMolecule
entity reference: Ammonia

Reference/UniProt P43623
type: UnificationXref
id: P43623
db: UniProt

Reference/ChEBI CHEBI 27812
type: UnificationXref
id: CHEBI:27812
db: ChEBI

Adenosine monophosphate
type: SmallMolecule
entity reference: Adenosine monophosphate

Reference/HMDB HMDB0004119
type: UnificationXref
id: HMDB0004119
db: HMDB

Methylselenic acid
type: SmallMolecule
entity reference: Methylselenic acid

Reference/HMDB HMDB0060488
type: UnificationXref
id: HMDB0060488
db: HMDB

Reference/HMDB HMDB0004113
type: UnificationXref
id: HMDB0004113
db: HMDB

methylselenol
type: SmallMolecule
entity reference: methylselenol

Reference/HMDB HMDB0060489
type: UnificationXref
id: HMDB0060489
db: HMDB

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

Reference/KEGG Compound C00109
type: UnificationXref
id: C00109
db: KEGG Compound

thioredoxin reductase 2
type: Protein
entity reference: thioredoxin reductase 2

NADPH
type: SmallMolecule
entity reference: NADPH

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Acetic acid
type: SmallMolecule
entity reference: Acetic acid

Saccharomyces cerevisiae
type: BioSource
xref: Reference/TAXONOMY 4932

Reference/BioCyc SELENOMETHIONINE
type: UnificationXref
id: SELENOMETHIONINE
db: BioCyc

ChemicalStructure/PW C002066
type: ChemicalStructure
structure format: SMILES
structure data: NC(CC[SeH])C(O)=O

Reference/CAS 600-18-0
type: UnificationXref
id: 600-18-0
db: CAS

NADP
type: SmallMolecule
entity reference: NADP

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

Reference/CAS 10236-58-5
type: UnificationXref
id: 10236-58-5
db: CAS

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

ChemicalStructure/PW C002064
type: ChemicalStructure
structure format: SMILES
structure data: C[Se]C[C@H](N)C(O)=O

methionine--tRNA ligase MES1
type: Protein
entity reference: methionine--tRNA ligase MES1

Compound/PW C000032/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

Compound/PW C000146/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

cystathionine gamma-synthase
type: Protein
entity reference: cystathionine gamma-synthase

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

thioredoxin reductase 1
type: Protein
entity reference: thioredoxin reductase 1

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

methionine--tRNA ligase MSM1
type: Protein
entity reference: methionine--tRNA ligase MSM1

O-succinyl-L-homoserine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 16160
chemical formula: C8H13NO6
molecular weight: 219.07428
structure: ChemicalStructure/PW C040920

Compound/PW C044571/Stoichiometry/1.0
type: Stoichiometry
physical entity: Methylselenic acid
stoichiometric coefficient: 1.0

Reference/BioCyc L-SELENOCYSTEINE
type: UnificationXref
id: L-SELENOCYSTEINE
db: BioCyc

Reference/ChemSpider 217
type: UnificationXref
id: 217
db: ChemSpider

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

Reference/BioCyc SUC
type: UnificationXref
id: SUC
db: BioCyc

RNA/9/Stoichiometry/1.0
type: Stoichiometry
physical entity: tRNA(Met)
stoichiometric coefficient: 1.0

Acetylhomoserine
type: SmallMoleculeReference
xref: Reference/CAS 7540-67-2
xref: Reference/PubChem-compound 528
xref: Reference/HMDB HMDB0029423
xref: Reference/ChEBI CHEBI 7671
xref: Reference/ChemSpider 513
chemical formula: C6H11NO4
molecular weight: 161.0688
structure: ChemicalStructure/PW C010666

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Reference/HMDB HMDB0003966
type: UnificationXref
id: HMDB0003966
db: HMDB

Reference/HMDB HMDB0003288
type: UnificationXref
id: HMDB0003288
db: HMDB

Reference/UniProt P05694
type: UnificationXref
id: P05694
db: UniProt

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/PubChem-compound 16722111
type: UnificationXref
id: 16722111
db: PubChem-compound

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/PubChem-compound 16722112
type: UnificationXref
id: 16722112
db: PubChem-compound

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Tetrahydropteroyltri-L-glutamate
type: SmallMoleculeReference
xref: Reference/ChemSpider 17625690
xref: Reference/KEGG Compound C04144
xref: Reference/HMDB HMDB0012290
xref: Reference/BioCyc CPD-1302
xref: Reference/PubChem-compound 16722112
xref: Reference/ChEBI CHEBI 17420
chemical formula: C29H37N9O12
molecular weight: 703.25616
structure: ChemicalStructure/PW C007828

Selenomethionine
type: SmallMoleculeReference
xref: Reference/BioCyc SELENOMETHIONINE
xref: Reference/ChemSpider 14375
xref: Reference/HMDB HMDB0003966
xref: Reference/PubChem-compound 15103
xref: Reference/CAS 1464-42-2
xref: Reference/KEGG Compound C05335
xref: Reference/ChEBI CHEBI 27585
chemical formula: C5H11NO2Se
molecular weight: 196.9955
structure: ChemicalStructure/PW C002019

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/BioCyc 2-OXOBUTANOATE
type: UnificationXref
id: 2-OXOBUTANOATE
db: BioCyc

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/ChemSpider 1031
type: UnificationXref
id: 1031
db: ChemSpider

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Compound/PW C010666/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetylhomoserine
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

cystathionine beta-lyase
type: ProteinReference
xref: Reference/UniProt P43623

Reference/CAS 7664-41-7
type: UnificationXref
id: 7664-41-7
db: CAS

cystathionine beta-lyase subunit 2
type: ProteinReference
xref: Reference/UniProt P53101

Reference/HMDB HMDB0029423
type: UnificationXref
id: HMDB0029423
db: HMDB

cystathionine gamma-lyase
type: ProteinReference
xref: Reference/UniProt P31373

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Reference/ChEBI CHEBI 15741
type: UnificationXref
id: CHEBI:15741
db: ChEBI

Tetrahydropteroyltri-L-glutamate
type: SmallMolecule
entity reference: Tetrahydropteroyltri-L-glutamate

Reference/PubChem-compound 222
type: UnificationXref
id: 222
db: PubChem-compound

Compound/PW C007828/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tetrahydropteroyltri-L-glutamate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00014
type: UnificationXref
id: C00014
db: KEGG Compound

Reference/PubChem-compound 1110
type: UnificationXref
id: 1110
db: PubChem-compound

Selenomethionine
type: SmallMolecule
entity reference: Selenomethionine

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Reference/PubChem-compound 440763
type: UnificationXref
id: 440763
db: PubChem-compound

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/PubChem-compound 25076
type: UnificationXref
id: 25076
db: PubChem-compound

N5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase
type: ProteinReference
xref: Reference/UniProt P05694

Succinic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000254
xref: Reference/CAS 110-15-6
xref: Reference/ChEBI CHEBI 15741
xref: Reference/KEGG Compound C00042
xref: Reference/ChemSpider 1078
xref: Reference/PubChem-compound 1110
xref: Reference/BioCyc SUC
chemical formula: C4H6O4
molecular weight: 118.02661
structure: ChemicalStructure/PW C000174

Reference/ChEBI CHEBI 64685
type: UnificationXref
id: CHEBI:64685
db: ChEBI

Reference/UniProt P38816
type: UnificationXref
id: P38816
db: UniProt

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Selenocysteine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 16633
xref: Reference/PubChem-compound 25076
xref: Reference/CAS 10236-58-5
xref: Reference/HMDB HMDB0003288
xref: Reference/BioCyc L-SELENOCYSTEINE
xref: Reference/KEGG Compound C05688
xref: Reference/ChemSpider 23436
chemical formula: C3H7NO2Se
molecular weight: 168.9642
structure: ChemicalStructure/PW C001829

Reference/ChemSpider 389632
type: UnificationXref
id: 389632
db: ChemSpider

Compound/PW C000003/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Ketobutyric acid
stoichiometric coefficient: 1.0

Reference/BioCyc CPD-1302
type: UnificationXref
id: CPD-1302
db: BioCyc

Reference/ChemSpider 129633
type: UnificationXref
id: 129633
db: ChemSpider

Reference/KEGG Compound C00022
type: UnificationXref
id: C00022
db: KEGG Compound

Reference/ChEBI CHEBI 16160
type: UnificationXref
id: CHEBI:16160
db: ChEBI

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

Reference/SMPDB SMP0002371
type: UnificationXref
id: SMP0002371
db: SMPDB

Reference/ChEBI CHEBI 26630
type: UnificationXref
id: CHEBI:26630
db: ChEBI

Reference/HMDB HMDB0000243
type: UnificationXref
id: HMDB0000243
db: HMDB

Reference/BioCyc ACET
type: UnificationXref
id: ACET
db: BioCyc

Reference/HMDB HMDB0000005
type: UnificationXref
id: HMDB0000005
db: HMDB

ChemicalStructure/PW C000003
type: ChemicalStructure
structure format: SMILES
structure data: CCC(=O)C(O)=O

Compound/PW C000143/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0006343
type: UnificationXref
id: HMDB0006343
db: HMDB

Compound/PW C040920/Stoichiometry/1.0
type: Stoichiometry
physical entity: O-succinyl-L-homoserine
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00033
type: UnificationXref
id: C00033
db: KEGG Compound

Selenocystathionine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 26630
xref: Reference/ChemSpider 88693
xref: Reference/PubChem-compound 98223
xref: Reference/KEGG Compound C05699
xref: Reference/HMDB HMDB0006343
xref: Reference/CAS 2196-58-9
chemical formula: C7H14N2O4Se
molecular weight: 270.01187
structure: ChemicalStructure/PW C002727

Reference/UniProt P47164
type: UnificationXref
id: P47164
db: UniProt

Reference/ChEBI CHEBI 30831
type: UnificationXref
id: CHEBI:30831
db: ChEBI

Reference/HMDB HMDB0000254
type: UnificationXref
id: HMDB0000254
db: HMDB

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

Water
type: SmallMolecule
entity reference: Water

ChemicalStructure/PW C000174
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(O)=O

Reference/ChEBI CHEBI 77012
type: UnificationXref
id: CHEBI:77012
db: ChEBI

thioredoxin reductase
type: Complex
component: thioredoxin reductase 1
component: thioredoxin reductase 2

Reference/ChEBI CHEBI 29173
type: UnificationXref
id: CHEBI:29173
db: ChEBI

Reference/PubChem-compound 528
type: UnificationXref
id: 528
db: PubChem-compound

Reference/UniProt P31373
type: UnificationXref
id: P31373
db: UniProt

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

ChemicalStructure/PW C001829
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](C[SeH])C(O)=O

Compound/PW C002019/Stoichiometry/1.0
type: Stoichiometry
physical entity: Selenomethionine
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00042
type: UnificationXref
id: C00042
db: KEGG Compound

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/ChemSpider 1078
type: UnificationXref
id: 1078
db: ChemSpider

Reaction6777
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002727/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002066/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035/Stoichiometry/1.0
right: Ammonia
right: Selenohomocysteine
right: Pyruvic acid
spontaneous: false
left: Water
left: Selenocystathionine
name: Selenocystathionine + Water → Ammonia + Pyruvic acid + Selenohomocysteine
conversion direction: LEFT_TO_RIGHT

Se-Methylselenocysteine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 27812
xref: Reference/ChemSpider 129633
xref: Reference/KEGG Compound C05689
xref: Reference/CAS 26046-90-2
xref: Reference/HMDB HMDB0004113
xref: Reference/PubChem-compound 147004
chemical formula: C4H9NO2Se
molecular weight: 182.97984
structure: ChemicalStructure/PW C002064

Selenohomocysteine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 440763
xref: Reference/ChemSpider 389632
xref: Reference/HMDB HMDB0004119
xref: Reference/CAS 29412-93-9
xref: Reference/BioCyc SELENOHOMOCYSTEINE
xref: Reference/KEGG Compound C05698
chemical formula: C4H9NO2Se
molecular weight: 182.97984
structure: ChemicalStructure/PW C002066

Compound/PW C000170/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 14375
type: UnificationXref
id: 14375
db: ChemSpider

thioredoxin reductase 1
type: ProteinReference
xref: Reference/UniProt P29509

Se-Methylselenocysteine
type: SmallMolecule
entity reference: Se-Methylselenocysteine

Selenohomocysteine
type: SmallMolecule
entity reference: Selenohomocysteine

methionine--tRNA ligase MES1
type: ProteinReference
xref: Reference/UniProt P00958

ReactionCatalysis6741
type: Catalysis
controller: methionyl-tRNA synthetase
controlled: 6.1.1.10
control type: ACTIVATION

methionine--tRNA ligase MSM1
type: ProteinReference
xref: Reference/UniProt P22438

cystathionine gamma-synthase
type: ProteinReference
xref: Reference/UniProt P47164

6.1.1.10
type: BiochemicalReaction
participant stoichiometry: RNA/9/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170/Stoichiometry/1.0
participant stoichiometry: Compound/Generic10/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002019/Stoichiometry/1.0
right: Selenomethionyl-tRNA(Met)
right: Adenosine monophosphate
right: Pyrophosphate
spontaneous: false
EC number: 6.1.1.10
left: tRNA(Met)
left: Adenosine triphosphate
left: Selenomethionine
name: Adenosine triphosphate + Selenomethionine + tRNA(Met) → Adenosine monophosphate + Pyrophosphate + Selenomethionyl-tRNA(Met)
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis6744
type: Catalysis
controller: cystathionine beta-lyase
controlled: Reaction6777
control type: ACTIVATION

4.4.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C044570/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000003/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002019/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035/Stoichiometry/1.0
right: Ammonia
right: 2-Ketobutyric acid
right: methylselenol
spontaneous: false
EC number: 4.4.1.1
left: Water
left: Selenomethionine
name: Selenomethionine + Water → 2-Ketobutyric acid + Ammonia + methylselenol
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis6743
type: Catalysis
controller: N5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase
controlled: Reaction6776
control type: ACTIVATION

ReactionCatalysis6742
type: Catalysis
controller: cystathionine gamma-lyase
controlled: 4.4.1.1
control type: ACTIVATION

Reaction6776
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002066/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007732/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002019/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007828/Stoichiometry/1.0
right: Tetrahydropteroyltri-L-glutamate
right: Selenomethionine
spontaneous: false
left: 5-Methyltetrahydropteroyltri-L-glutamate
left: Selenohomocysteine
name: 5-Methyltetrahydropteroyltri-L-glutamate + Selenohomocysteine ↔ Selenomethionine + Tetrahydropteroyltri-L-glutamate
conversion direction: REVERSIBLE

Reference/ChEBI CHEBI 16633
type: UnificationXref
id: CHEBI:16633
db: ChEBI

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

thioredoxin reductase 2
type: ProteinReference
xref: Reference/UniProt P38816

Compound/Generic10/Stoichiometry/1.0
type: Stoichiometry
physical entity: Selenomethionyl-tRNA(Met)
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000029
type: ChemicalStructure
structure format: SMILES
structure data: CC(O)=O

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Compound/PW C000164/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 1.0

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

Reference/ChemSpider 17625690
type: UnificationXref
id: 17625690
db: ChemSpider

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

Reference/CAS 127-17-3
type: UnificationXref
id: 127-17-3
db: CAS

Reference/BioCyc AMMONIA
type: UnificationXref
id: AMMONIA
db: BioCyc

ChemicalStructure/PW C000035
type: ChemicalStructure
structure format: SMILES
structure data: N

cystathionine beta-lyase
type: Complex
component: cystathionine beta-lyase
component: cystathionine beta-lyase subunit 2

Reference/PubChem-compound 124489574
type: UnificationXref
id: 124489574
db: PubChem-compound

Reference/CAS 26046-90-2
type: UnificationXref
id: 26046-90-2
db: CAS

ChemicalStructure/PW C044570
type: ChemicalStructure
structure format: SMILES
structure data: C[SeH]

Reference/CAS 1464-42-2
type: UnificationXref
id: 1464-42-2
db: CAS

Compound/PW C001829/Stoichiometry/1.0
type: Stoichiometry
physical entity: Selenocysteine
stoichiometric coefficient: 1.0

ChemicalStructure/PW C044571
type: ChemicalStructure
structure format: SMILES
structure data: C[Se](O)=O

Compound/PW C000029/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetic acid
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/ChEBI CHEBI 17614
type: UnificationXref
id: CHEBI:17614
db: ChEBI

Reference/BioCyc SELENOHOMOCYSTEINE
type: UnificationXref
id: SELENOHOMOCYSTEINE
db: BioCyc

Selenocystathionine
type: SmallMolecule
entity reference: Selenocystathionine

O-succinyl-L-homoserine
type: SmallMolecule
entity reference: O-succinyl-L-homoserine

Reference/PubChem-compound 15103
type: UnificationXref
id: 15103
db: PubChem-compound

5-Methyltetrahydropteroyltri-L-glutamate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 16722111
xref: Reference/BioCyc CPD-1302
xref: Reference/ChEBI CHEBI 17614
xref: Reference/ChemSpider 17625689
xref: Reference/KEGG Compound C04489
xref: Reference/HMDB HMDB0012177
chemical formula: C30H39N9O12
molecular weight: 717.2718
structure: ChemicalStructure/PW C007732

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

ChemicalStructure/PW C000164
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)C(O)=O

Reference/UniProt P22438
type: UnificationXref
id: P22438
db: UniProt

5-Methyltetrahydropteroyltri-L-glutamate
type: SmallMolecule
entity reference: 5-Methyltetrahydropteroyltri-L-glutamate

Compound/PW C044570/Stoichiometry/1.0
type: Stoichiometry
physical entity: methylselenol
stoichiometric coefficient: 1.0

ReactionCatalysis6763
type: Catalysis
controller: cystathionine gamma-synthase
controlled: Reaction6794
control type: ACTIVATION

ReactionCatalysis6762
type: Catalysis
controller: cystathionine gamma-synthase
controlled: 2.5.1.48
control type: ACTIVATION

Reference/ChemSpider 17625689
type: UnificationXref
id: 17625689
db: ChemSpider

2.5.1.48
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002727/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040920/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000174/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001829/Stoichiometry/1.0
right: Succinic acid
right: Selenocysteine
spontaneous: false
EC number: 2.5.1.48
left: Selenocystathionine
left: O-succinyl-L-homoserine
name: O-succinyl-L-homoserine + Selenocystathionine ↔ Selenocysteine + Succinic acid
conversion direction: REVERSIBLE

Reaction6794
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000029/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002727/Stoichiometry/1.0
participant stoichiometry: Compound/PW C010666/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001829/Stoichiometry/1.0
right: Selenocystathionine
right: Acetic acid
spontaneous: false
left: Selenocysteine
left: Acetylhomoserine
name: Acetylhomoserine + Selenocysteine ↔ Acetic acid + Selenocystathionine
conversion direction: REVERSIBLE

Reference/HMDB HMDB0000042
type: UnificationXref
id: HMDB0000042
db: HMDB

Reference/UniProt P29509
type: UnificationXref
id: P29509
db: UniProt

1.8.1.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C044570/Stoichiometry/1.0
participant stoichiometry: Compound/PW C044571/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Water
right: NADP
right: methylselenol
spontaneous: false
EC number: 1.8.1.9
left: Hydrogen Ion
left: Methylselenic acid
left: NADPH
name: Methylselenic acid + Hydrogen Ion + NADPH → NADP + Water + methylselenol
conversion direction: LEFT_TO_RIGHT

Reaction6796
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C044570/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002064/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035/Stoichiometry/1.0
right: Ammonia
right: Pyruvic acid
right: methylselenol
spontaneous: false
left: Water
left: Se-Methylselenocysteine
name: Se-Methylselenocysteine + Water → Ammonia + Pyruvic acid + methylselenol
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis6765
type: Catalysis
controller: cystathionine gamma-lyase
controlled: Reaction6796
control type: ACTIVATION

ReactionCatalysis6764
type: Catalysis
controller: thioredoxin reductase
controlled: 1.8.1.9
control type: ACTIVATION

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChEBI CHEBI 15366
type: UnificationXref
id: CHEBI:15366
db: ChEBI

Reference/CAS 29412-93-9
type: UnificationXref
id: 29412-93-9
db: CAS

Compound/PW C007732/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Methyltetrahydropteroyltri-L-glutamate
stoichiometric coefficient: 1.0

Compound/PW C000174/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinic acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17420
type: UnificationXref
id: CHEBI:17420
db: ChEBI

Reference/CAS 2196-58-9
type: UnificationXref
id: 2196-58-9
db: CAS

Reference/PubChem-compound 147004
type: UnificationXref
id: 147004
db: PubChem-compound

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reference/UniProt P00958
type: UnificationXref
id: P00958
db: UniProt

Reference/CAS 110-15-6
type: UnificationXref
id: 110-15-6
db: CAS

Reference/CAS 7540-67-2
type: UnificationXref
id: 7540-67-2
db: CAS

methylselenol
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 64685
xref: Reference/HMDB HMDB0060488
chemical formula: CH4Se
molecular weight: 95.94782
structure: ChemicalStructure/PW C044570

Selenocompound Metabolism
type: Pathway
pathway order: PathwayEnzymeReaction/25728
pathway order: PathwayEnzymeReaction/25729
pathway order: PathwayEnzymeReaction/25751
pathway order: PathwayEnzymeReaction/25730
pathway order: PathwayEnzymeReaction/25752
pathway order: PathwayEnzymeReaction/25731
pathway order: PathwayEnzymeReaction/25753
pathway order: PathwayEnzymeReaction/25754
pathway component: Reaction6777
pathway component: ReactionCatalysis6741
pathway component: ReactionCatalysis6763
pathway component: ReactionCatalysis6762
pathway component: 2.5.1.48
pathway component: Reaction6794
pathway component: 1.8.1.9
pathway component: 6.1.1.10
pathway component: ReactionCatalysis6744
pathway component: Reaction6796
pathway component: 4.4.1.1
pathway component: ReactionCatalysis6743
pathway component: ReactionCatalysis6765
pathway component: ReactionCatalysis6742
pathway component: Reaction6776
pathway component: ReactionCatalysis6764
xref: Reference/SMPDB SMP0002371
xref: Reference/PathWhiz PW002472
organism: Saccharomyces cerevisiae

Methylselenic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 77012
xref: Reference/PubChem-compound 124489574
xref: Reference/HMDB HMDB0060489
chemical formula: CH4O2Se
molecular weight: 127.93765
structure: ChemicalStructure/PW C044571

Reference/HMDB HMDB0000051
type: UnificationXref
id: HMDB0000051
db: HMDB

Reference/ChemSpider 171
type: UnificationXref
id: 171
db: ChemSpider

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/ChEBI CHEBI 32816
type: UnificationXref
id: CHEBI:32816
db: ChEBI

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/BioCyc PYRUVATE
type: UnificationXref
id: PYRUVATE
db: BioCyc

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

2-Ketobutyric acid
type: SmallMolecule
entity reference: 2-Ketobutyric acid

Reference/ChEBI CHEBI 7671
type: UnificationXref
id: CHEBI:7671
db: ChEBI

Selenomethionyl-tRNA(Met)
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 9100

Reference/ChemSpider 23436
type: UnificationXref
id: 23436
db: ChemSpider

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

ChemicalStructure/PW C007732
type: ChemicalStructure
structure format: SMILES

2-Ketobutyric acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 30831
xref: Reference/HMDB HMDB0000005
xref: Reference/CAS 600-18-0
xref: Reference/ChemSpider 57
xref: Reference/KEGG Compound C00109
xref: Reference/PubChem-compound 58
xref: Reference/BioCyc 2-OXOBUTANOATE
chemical formula: C4H6O3
molecular weight: 102.03169
structure: ChemicalStructure/PW C000003

Reference/ChEBI CHEBI 27585
type: UnificationXref
id: CHEBI:27585
db: ChEBI

Reference/UniProt P53101
type: UnificationXref
id: P53101
db: UniProt

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Reference/TAXONOMY 4932
type: UnificationXref
id: 4932
db: TAXONOMY

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

Selenomethionyl-tRNA(Met)
type: SmallMolecule
entity reference: Selenomethionyl-tRNA(Met)

methionyl-tRNA synthetase
type: Complex
component: methionine--tRNA ligase MES1
component: methionine--tRNA ligase MSM1

Reference/HMDB HMDB0012177
type: UnificationXref
id: HMDB0012177
db: HMDB

Reference/ChemSpider 513
type: UnificationXref
id: 513
db: ChemSpider

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/HMDB HMDB0012290
type: UnificationXref
id: HMDB0012290
db: HMDB

tRNA(Met)
type: RnaReference
xref: Reference/ChEBI CHEBI 29173

ChemicalStructure/PW C010666
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)OCCC(N)C(O)=O

Reference/PubChem-compound 1060
type: UnificationXref
id: 1060
db: PubChem-compound

N5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase
type: Protein
entity reference: N5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

cystathionine gamma-lyase
type: Protein
entity reference: cystathionine gamma-lyase

ChemicalStructure/PW C007828
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C002019
type: ChemicalStructure
structure format: SMILES
structure data: C[Se]CCC(N)C(O)=O

Reference/PubChem-compound 176
type: UnificationXref
id: 176
db: PubChem-compound

Reference/PubChem-compound 98223
type: UnificationXref
id: 98223
db: PubChem-compound