Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/KEGG Compound C00319
type: UnificationXref
id: C00319
db: KEGG Compound

3.1.3.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000184 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001070 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Endoplasmic Reticulum/Stoichiometry/1.0
right: Adenosine triphosphate
right: Sphinganine
spontaneous: false
EC number: 3.1.3.-
left: Sphinganine 1-phosphate
left: Adenosine diphosphate
name: Adenosine diphosphate + Sphinganine 1-phosphate → Adenosine triphosphate + Sphinganine
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 439161
type: UnificationXref
id: 439161
db: PubChem-compound

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/KEGG Compound C00550
type: UnificationXref
id: C00550
db: KEGG Compound

Reference/BioCyc DEHYDROSPHINGANINE
type: UnificationXref
id: DEHYDROSPHINGANINE
db: BioCyc

Compound/PW C001065/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

2.3.1.50
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000120 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001031 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001139 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
right: 3-Dehydrosphinganine
right: Carbon dioxide
spontaneous: false
EC number: 2.3.1.50
left: Palmitoyl-CoA
left: L-Serine
name: L-Serine + Palmitoyl-CoA → 3-Dehydrosphinganine + Carbon dioxide
conversion direction: LEFT_TO_RIGHT

1.1.1.102
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001139 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000184 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
right: 3-Dehydrosphinganine
right: NADP
spontaneous: false
EC number: 1.1.1.102
left: Sphinganine
left: NADPH
name: NADPH + Sphinganine → 3-Dehydrosphinganine + NADP
conversion direction: LEFT_TO_RIGHT

2.7.1.91
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000184 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001070 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: Sphinganine 1-phosphate
spontaneous: false
EC number: 2.7.1.91
left: Sphinganine
left: Adenosine triphosphate
name: Adenosine triphosphate + Sphinganine → Adenosine diphosphate + Sphinganine 1-phosphate
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc SPHINGO-MYELIN
type: UnificationXref
id: SPHINGO-MYELIN
db: BioCyc

Reference/HMDB HMDB0006752
type: UnificationXref
id: HMDB0006752
db: HMDB

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/PathWhiz PW002479
type: UnificationXref
id: PW002479
db: PathWhiz

Reference/ChEBI CHEBI 17115
type: UnificationXref
id: CHEBI:17115
db: ChEBI

SM(d18:1/18:0)
type: SmallMolecule
cellular location: Golgi Apparatus
entity reference: SM(d18:1/18:0)

Dihydroceramide
type: SmallMolecule
entity reference: Dihydroceramide

Sphingosine 1-phosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Sphingosine 1-phosphate

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Glycine and Serine Metabolism
type: Pathway
xref: Reference/SMPDB SMP0121140
xref: Reference/PathWhiz PW122420
name: ActivatingSubPathway

Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

SubPathwayControl110033
type: Interaction
name: SubPathway110033Control
name: ActivatingSubPathwayControl
participant: L-Serine
participant: Glycine and Serine Metabolism

Unknown
type: ProteinReference
organism: Saccharomyces cerevisiae

Reference/BRENDA TISSUE ONTOLOGY BTO 0000759
type: UnificationXref
id: BTO:0000759
db: BRENDA TISSUE ONTOLOGY

Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Adenosine diphosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Adenosine diphosphate

Reference/ChEBI CHEBI 15380
type: UnificationXref
id: CHEBI:15380
db: ChEBI

Reference/ChemSpider 959
type: UnificationXref
id: 959
db: ChemSpider

Reference/PubChem-compound 16755624
type: UnificationXref
id: 16755624
db: PubChem-compound

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Succinyl-CoA
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00091
xref: Reference/CAS 604-98-8
xref: Reference/ChemSpider 388307
xref: Reference/PubChem-compound 439161
xref: Reference/ChEBI CHEBI 15380
xref: Reference/BioCyc 3-METHYLBENZYLSUCCINYL-COA
xref: Reference/HMDB HMDB0001022
chemical formula: C25H40N7O19P3S
molecular weight: 867.1312
structure: ChemicalStructure/PW C000808

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

2.7.8.27
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002313 Golgi Apparatus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002928 Golgi Apparatus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001040 Golgi Apparatus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C003990 Golgi Apparatus/Stoichiometry/1.0
right: Galactosylglycerol
right: SM(d18:1/18:0)
spontaneous: false
EC number: 2.7.8.27
left: Ceramide (d18:1/18:0)
left: PC(15:0/18:2(9Z,12Z))
name: Ceramide (d18:1/18:0) + PC(15:0/18:2(9Z,12Z)) → Galactosylglycerol + SM(d18:1/18:0)
conversion direction: LEFT_TO_RIGHT

3.1.4.12
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002313 Golgi Apparatus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001040 Golgi Apparatus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001202 Golgi Apparatus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Golgi Apparatus/Stoichiometry/1.0
right: Ceramide (d18:1/18:0)
right: Phosphorylcholine
spontaneous: false
EC number: 3.1.4.12
left: SM(d18:1/18:0)
left: Water
name: SM(d18:1/18:0) + Water → Ceramide (d18:1/18:0) + Phosphorylcholine
conversion direction: LEFT_TO_RIGHT

Compound/PW C002313 Golgi Apparatus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ceramide (d18:1/18:0)
stoichiometric coefficient: 1.0

Reference/ChemSpider 5736
type: UnificationXref
id: 5736
db: ChemSpider

Reference/UniProt P28496
type: UnificationXref
id: P28496
db: UniProt

Compound/PW C001070 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sphinganine 1-phosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 559277
type: UnificationXref
id: 559277
db: ChemSpider

BiologicalState212
type: BioSource
xref: Reference/TAXONOMY 4932
name: Saccharomyces cerevisiae, Liver
tissue: Liver

Reference/KEGG Compound C00346
type: UnificationXref
id: C00346
db: KEGG Compound

Reference/KEGG Compound C00588
type: UnificationXref
id: C00588
db: KEGG Compound

Unknown
type: Protein
cellular location: Cell Membrane
entity reference: Unknown

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Saccharomyces cerevisiae
type: BioSource
xref: Reference/TAXONOMY 4932

4.1.2.27
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001193 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000188 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000149 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Palmitaldehyde
right: O-Phosphoethanolamine
spontaneous: false
EC number: 4.1.2.27
left: Sphingosine 1-phosphate
name: Sphingosine 1-phosphate → O-Phosphoethanolamine + Palmitaldehyde
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

2.7.1.91
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000188 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000172 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Sphingosine 1-phosphate
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.1.91
left: Sphingosine
left: Adenosine triphosphate
name: Adenosine triphosphate + Sphingosine → Adenosine diphosphate + Sphingosine 1-phosphate
conversion direction: LEFT_TO_RIGHT

3.1.3.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000188 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000172 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Sphingosine
right: Adenosine triphosphate
spontaneous: false
EC number: 3.1.3.-
left: Sphingosine 1-phosphate
left: Adenosine diphosphate
name: Adenosine diphosphate + Sphingosine 1-phosphate → Adenosine triphosphate + Sphingosine
conversion direction: LEFT_TO_RIGHT

3.1.3.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000188 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000172 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
right: Sphingosine 1-phosphate
right: Water
spontaneous: false
EC number: 3.1.3.4
left: Phosphate
left: Sphingosine
name: Phosphate + Sphingosine → Sphingosine 1-phosphate + Water
conversion direction: LEFT_TO_RIGHT

Compound/PW C003990 Golgi Apparatus/Stoichiometry/1.0
type: Stoichiometry
physical entity: PC(15:0/18:2(9Z,12Z))
stoichiometric coefficient: 1.0

3.1.3.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001070 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000184 Cell Membrane/Stoichiometry/1.0
right: Phosphate
right: Sphinganine
spontaneous: false
EC number: 3.1.3.4
left: Sphinganine 1-phosphate
left: Water
name: Sphinganine 1-phosphate + Water → Phosphate + Sphinganine
conversion direction: LEFT_TO_RIGHT

4.1.2.27
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001193 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000149 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001070 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Palmitaldehyde
right: O-Phosphoethanolamine
spontaneous: false
EC number: 4.1.2.27
left: Sphinganine 1-phosphate
name: Sphinganine 1-phosphate → O-Phosphoethanolamine + Palmitaldehyde
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000808
type: ChemicalStructure
structure format: SMILES

Galactosylglycerol
type: SmallMoleculeReference
xref: Reference/ChemSpider 570889
xref: Reference/HMDB HMDB0006790
xref: Reference/ChEBI CHEBI 15754
xref: Reference/PubChem-compound 656504
xref: Reference/KEGG Compound C05401
chemical formula: C9H18O8
molecular weight: 254.10017
structure: ChemicalStructure/PW C002928

Reference/PubChem-compound 24778664
type: UnificationXref
id: 24778664
db: PubChem-compound

Reference/HMDB HMDB0006790
type: UnificationXref
id: HMDB0006790
db: HMDB

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Compound/PW C000146 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/BioCyc PHOSPHATIDYLCHOLINE
type: UnificationXref
id: PHOSPHATIDYLCHOLINE
db: BioCyc

Reference/CAS 1071-23-4
type: UnificationXref
id: 1071-23-4
db: CAS

Compound/PW C001202 Golgi Apparatus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphorylcholine
stoichiometric coefficient: 1.0

Ferrocytochrome
type: SmallMolecule
entity reference: Ferrocytochrome

Reference/BioCyc PALMITALDEHYDE
type: UnificationXref
id: PALMITALDEHYDE
db: BioCyc

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/UniProt P25045
type: UnificationXref
id: P25045
db: UniProt

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

NADPH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADPH

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

3.5.1.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000184/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002905/Stoichiometry/1.0
right: Sphinganine
spontaneous: false
EC number: 3.5.1.-
left: Dihydroceramide
name: Dihydroceramide → Sphinganine
conversion direction: LEFT_TO_RIGHT

2.3.1.24
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000808/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000184/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002905/Stoichiometry/1.0
right: Coenzyme A
right: Dihydroceramide
spontaneous: false
EC number: 2.3.1.24
left: Sphinganine
left: Succinyl-CoA
name: Sphinganine + Succinyl-CoA → Coenzyme A + Dihydroceramide
conversion direction: LEFT_TO_RIGHT

1.-.-.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C008134/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002151/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040779/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000184/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Water
right: Phytosphingosine
right: ferricytochrome c
spontaneous: false
EC number: 1.-.-.-
left: Sphinganine
left: Hydrogen Ion
left: Oxygen
left: Ferrocytochrome
name: Ferrocytochrome + Hydrogen Ion + Oxygen + Sphinganine ↔ Phytosphingosine + Water + ferricytochrome c
conversion direction: REVERSIBLE

Compound/PW C000188 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sphingosine 1-phosphate
stoichiometric coefficient: 1.0

Dihydroceramide
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 31488
xref: Reference/ChemSpider 21436314
xref: Reference/HMDB HMDB0006752
xref: Reference/PubChem-compound 16755624
xref: Reference/KEGG Compound C12126
chemical formula: C19H39NO3
molecular weight: 329.293
structure: ChemicalStructure/PW C002905

Reference/ChemSpider 388895
type: UnificationXref
id: 388895
db: ChemSpider

Compound/PW C001070 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sphinganine 1-phosphate
stoichiometric coefficient: 1.0

Sphinganine 1-phosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Sphinganine 1-phosphate

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/ChEBI CHEBI 16393
type: UnificationXref
id: CHEBI:16393
db: ChEBI

Compound/PW C000172 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sphingosine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 122121
type: UnificationXref
id: 122121
db: PubChem-compound

Compound/PW C001070 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sphinganine 1-phosphate
stoichiometric coefficient: 1.0

Reference/CAS 554-62-1
type: UnificationXref
id: 554-62-1
db: CAS

Compound/PW C001139 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Dehydrosphinganine
stoichiometric coefficient: 1.0

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Compound/PW C000184 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sphinganine
stoichiometric coefficient: 1.0

ReactionCatalysis6796
type: Catalysis
controller: Unknown
controlled: 1.1.1.102
control type: ACTIVATION

ReactionCatalysis6795
type: Catalysis
controller: Serine palmitoyltransferase 1
controlled: 2.3.1.50
control type: ACTIVATION

ReactionCatalysis6799
type: Catalysis
controller: Unknown
controlled: 3.1.3.4
control type: ACTIVATION

ReactionCatalysis6798
type: Catalysis
controller: Unknown
controlled: 3.1.3.-
control type: ACTIVATION

ReactionCatalysis6797
type: Catalysis
controller: Unknown
controlled: 2.7.1.91
control type: ACTIVATION

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/ChemSpider 388307
type: UnificationXref
id: 388307
db: ChemSpider

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Compound/PW C002905/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydroceramide
stoichiometric coefficient: 1.0

Reference/BioCyc PHOSPHORYL-CHOLINE
type: UnificationXref
id: PHOSPHORYL-CHOLINE
db: BioCyc

Compound/PW C000172 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sphingosine
stoichiometric coefficient: 1.0

NADP
type: SmallMolecule
cellular location: Cytosol
entity reference: NADP

Reference/KEGG Compound C12126
type: UnificationXref
id: C12126
db: KEGG Compound

Sphinganine
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Sphinganine

Reference/KEGG Compound C00154
type: UnificationXref
id: C00154
db: KEGG Compound

ChemicalStructure/PW C001139
type: ChemicalStructure
structure format: SMILES
structure data: CCCCCCCCCCCCCCCC(=O)[C@@H](N)CO

Compound/PW C001034 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C01120
type: UnificationXref
id: C01120
db: KEGG Compound

Reference/KEGG Compound C00157
type: UnificationXref
id: C00157
db: KEGG Compound

Water
type: SmallMolecule
entity reference: Water

Reference/ChEBI CHEBI 31488
type: UnificationXref
id: CHEBI:31488
db: ChEBI

Reference/HMDB HMDB0004610
type: UnificationXref
id: HMDB0004610
db: HMDB

Reference/HMDB HMDB0001348
type: UnificationXref
id: HMDB0001348
db: HMDB

Reference/PathWhiz PW122420
type: UnificationXref
id: PW122420
db: PathWhiz

Reference/CAS 104404-17-3
type: UnificationXref
id: 104404-17-3
db: CAS

ChemicalStructure/PW C000172
type: ChemicalStructure
structure format: SMILES
structure data: CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)CO

Compound/PW C000414 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Adenosine triphosphate

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Reference/HMDB HMDB0000252
type: UnificationXref
id: HMDB0000252
db: HMDB

Water
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Water

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Compound/PW C000808/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinyl-CoA
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001031
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000184
type: ChemicalStructure
structure format: SMILES
structure data: CCCCCCCCCCCCCCC[C@@H](O)[C@@H](N)CO

Reference/CAS 604-98-8
type: UnificationXref
id: 604-98-8
db: CAS

Sphinganine
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Sphinganine

Reference/HMDB HMDB0000269
type: UnificationXref
id: HMDB0000269
db: HMDB

ChemicalStructure/PW C000188
type: ChemicalStructure
structure format: SMILES

Serine palmitoyltransferase 1
type: ProteinReference
xref: Reference/UniProt P25045
organism: Saccharomyces cerevisiae

Reference/KEGG Compound C12144
type: UnificationXref
id: C12144
db: KEGG Compound

Reference/PubChem-compound 5283588
type: UnificationXref
id: 5283588
db: PubChem-compound

Compound/PW C000120 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Serine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 18132
type: UnificationXref
id: CHEBI:18132
db: ChEBI

Reference/PubChem-compound 644260
type: UnificationXref
id: 644260
db: PubChem-compound

ChemicalStructure/PW C000149
type: ChemicalStructure
structure format: SMILES
structure data: NCCOP(O)(O)=O

Reference/CAS 16105-69-4
type: UnificationXref
id: 16105-69-4
db: CAS

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Phosphorylcholine
type: SmallMolecule
cellular location: Golgi Apparatus
entity reference: Phosphorylcholine

Reference/BioCyc CERAMIDE
type: UnificationXref
id: CERAMIDE
db: BioCyc

Reference/CAS 19794-97-9
type: UnificationXref
id: 19794-97-9
db: CAS

Sphinganine 1-phosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Sphinganine 1-phosphate

Reference/HMDB HMDB0000277
type: UnificationXref
id: HMDB0000277
db: HMDB

sphinganine C4-monooxygenase
type: ProteinReference
xref: Reference/UniProt P38992

Acyl-CoA-dependent ceramide synthase 2
type: ProteinReference
xref: Reference/UniProt P28496

Reference/HMDB HMDB0001480
type: UnificationXref
id: HMDB0001480
db: HMDB

Ferrocytochrome
type: SmallMoleculeReference
xref: Reference/CAS 1818-68-4
xref: Reference/KEGG Compound C05183
xref: Reference/ChEBI CHEBI 15910
xref: Reference/HMDB HMDB0012947
chemical formula: C33H32FeN4O4
molecular weight: 604.1762
structure: ChemicalStructure/PW C008134

Acyl-CoA-dependent ceramide synthase
type: ProteinReference
xref: Reference/UniProt P38703

Compound/PW C008134/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ferrocytochrome
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Water
type: SmallMolecule
cellular location: Golgi Apparatus
entity reference: Water

Palmitoyl-CoA
type: SmallMolecule
cellular location: Cytosol
entity reference: Palmitoyl-CoA

Reference/KEGG Compound C00065
type: UnificationXref
id: C00065
db: KEGG Compound

ChemicalStructure/PW C040779
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Unknown
type: Protein
cellular location: Golgi Apparatus
entity reference: Unknown

Reference/CAS 107-73-3
type: UnificationXref
id: 107-73-3
db: CAS

Reference/KEGG Compound C00195
type: UnificationXref
id: C00195
db: KEGG Compound

Reference/ChemSpider 21436314
type: UnificationXref
id: 21436314
db: ChemSpider

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Compound/PW C001031 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Palmitoyl-CoA
stoichiometric coefficient: 1.0

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Unknown
type: Protein
entity reference: Unknown

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Reference/KEGG Compound C05401
type: UnificationXref
id: C05401
db: KEGG Compound

Sphingolipid Metabolism
type: Pathway
pathway order: PathwayEnzymeReaction/25813
pathway order: PathwayEnzymeReaction/25814
pathway order: PathwaySubPathway/110033
pathway order: PathwayEnzymeReaction/25793
pathway order: PathwayEnzymeReaction/25794
pathway order: PathwayEnzymeReaction/25784
pathway order: PathwayEnzymeReaction/25785
pathway order: PathwayEnzymeReaction/25786
pathway order: PathwayEnzymeReaction/25787
pathway order: PathwayEnzymeReaction/25788
pathway order: PathwayEnzymeReaction/25799
pathway order: PathwayEnzymeReaction/25789
pathway order: PathwayEnzymeReaction/25800
pathway order: PathwayEnzymeReaction/25791
pathway order: PathwayEnzymeReaction/25792
pathway order: PathwayEnzymeReaction/2123923
pathway component: 3.1.3.-
pathway component: 2.3.1.50
pathway component: 1.1.1.102
pathway component: 2.7.1.91
pathway component: ReactionCatalysis6796
pathway component: ReactionCatalysis6795
pathway component: ReactionCatalysis6811
pathway component: ReactionCatalysis6799
pathway component: ReactionCatalysis6810
pathway component: ReactionCatalysis6798
pathway component: 2.7.8.27
pathway component: ReactionCatalysis6797
pathway component: 3.1.4.12
pathway component: ReactionCatalysis6804
pathway component: 3.5.1.-
pathway component: SubPathwayControl110033
pathway component: 4.1.2.27
pathway component: ReactionCatalysis6803
pathway component: 2.3.1.24
pathway component: ReactionCatalysis6825
pathway component: ReactionCatalysis6802
pathway component: ReactionCatalysis6824
pathway component: 1.-.-.-
pathway component: ReactionCatalysis6823
pathway component: 3.1.3.4
pathway component: ReactionCatalysis6805
pathway component: ReactionCatalysis6800
xref: Reference/PathWhiz PW002479
xref: Reference/SMPDB SMP0002378
organism: Saccharomyces cerevisiae

Sphinganine
type: SmallMolecule
cellular location: Cytosol
entity reference: Sphinganine

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Compound/PW C001040 Golgi Apparatus/Stoichiometry/1.0
type: Stoichiometry
physical entity: SM(d18:1/18:0)
stoichiometric coefficient: 1.0

Sphingosine 1-phosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Sphingosine 1-phosphate

Phosphorylcholine
type: SmallMoleculeReference
xref: Reference/CAS 107-73-3
xref: Reference/HMDB HMDB0001565
xref: Reference/BioCyc PHOSPHORYL-CHOLINE
xref: Reference/PubChem-compound 1014
xref: Reference/ChEBI CHEBI 18132
xref: Reference/KEGG Compound C00588
xref: Reference/ChemSpider 989
chemical formula: C5H15NO4P
molecular weight: 184.07387
structure: ChemicalStructure/PW C001202

Sphingosine
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Sphingosine

ChemicalStructure/PW C002151
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/HMDB HMDB0001383
type: UnificationXref
id: HMDB0001383
db: HMDB

Reference/HMDB HMDB0001022
type: UnificationXref
id: HMDB0001022
db: HMDB

Reference/SMPDB SMP0121140
type: UnificationXref
id: SMP0121140
db: SMPDB

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

PC(15:0/18:2(9Z,12Z))
type: SmallMoleculeReference
xref: Reference/ChemSpider 24766615
xref: Reference/PubChem-compound 24778664
xref: Reference/HMDB HMDB0007940
xref: Reference/KEGG Compound C00157
xref: Reference/BioCyc PHOSPHATIDYLCHOLINE
chemical formula: C41H78NO8P
molecular weight: 743.5465
structure: ChemicalStructure/PW C003990

Reference/KEGG Compound C00091
type: UnificationXref
id: C00091
db: KEGG Compound

L-Serine
type: SmallMolecule
entity reference: L-Serine
name: SubPathwayActivator

ChemicalStructure/PW C001070
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 46961
type: UnificationXref
id: CHEBI:46961
db: ChEBI

L-Serine
type: SmallMoleculeReference
xref: Reference/ChemSpider 5736
xref: Reference/ChEBI CHEBI 17115
xref: Reference/CAS 56-45-1
xref: Reference/KEGG Compound C00065
xref: Reference/PubChem-compound 5951
xref: Reference/HMDB HMDB0000187
xref: Reference/BioCyc SER
chemical formula: C3H7NO3
molecular weight: 105.042595
structure: ChemicalStructure/PW C000120

Reference/UniProt P38992
type: UnificationXref
id: P38992
db: UniProt

Reference/HMDB HMDB0000187
type: UnificationXref
id: HMDB0000187
db: HMDB

ChemicalStructure/PW C001193
type: ChemicalStructure
structure format: SMILES
structure data: CCCCCCCCCCCCCCCC=O

Reference/PubChem-compound 984
type: UnificationXref
id: 984
db: PubChem-compound

Reference/TAXONOMY 4932
type: UnificationXref
id: 4932
db: TAXONOMY

Galactosylglycerol
type: SmallMolecule
cellular location: Golgi Apparatus
entity reference: Galactosylglycerol

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Unknown
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Unknown

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/ChemSpider 990
type: UnificationXref
id: 990
db: ChemSpider

Reference/HMDB HMDB0007940
type: UnificationXref
id: HMDB0007940
db: HMDB

Compound/PW C001034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001040
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5283560
type: UnificationXref
id: 5283560
db: PubChem-compound

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Compound/PW C001316 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15910
type: UnificationXref
id: CHEBI:15910
db: ChEBI

Reference/ChemSpider 989
type: UnificationXref
id: 989
db: ChemSpider

Reference/PubChem-compound 5283565
type: UnificationXref
id: 5283565
db: PubChem-compound

Compound/PW C001193 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Palmitaldehyde
stoichiometric coefficient: 1.0

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Reference/CAS 1818-68-4
type: UnificationXref
id: 1818-68-4
db: CAS

O-Phosphoethanolamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000224
xref: Reference/BioCyc PHOSPHORYL-ETHANOLAMINE
xref: Reference/ChemSpider 990
xref: Reference/PubChem-compound 1015
xref: Reference/KEGG Compound C00346
xref: Reference/ChEBI CHEBI 17553
xref: Reference/CAS 1071-23-4
chemical formula: C2H8NO4P
molecular weight: 141.01909
structure: ChemicalStructure/PW C000149

Reference/BioCyc PHOSPHORYL-ETHANOLAMINE
type: UnificationXref
id: PHOSPHORYL-ETHANOLAMINE
db: BioCyc

Compound/PW C002151/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phytosphingosine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1014
type: UnificationXref
id: 1014
db: PubChem-compound

Reference/PubChem-compound 1015
type: UnificationXref
id: 1015
db: PubChem-compound

Acyl-CoA-dependent ceramide synthase
type: Complex
component: Acyl-CoA-dependent ceramide synthase
component: Acyl-CoA-dependent ceramide synthase 2

Compound/PW C000414 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/BioCyc PHYTOSPINGOSINE
type: UnificationXref
id: PHYTOSPINGOSINE
db: BioCyc

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/PubChem-compound 656504
type: UnificationXref
id: 656504
db: PubChem-compound

Sphinganine 1-phosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Sphinganine 1-phosphate

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/PubChem-compound 3425
type: UnificationXref
id: 3425
db: PubChem-compound

Compound/PW C000143 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Reference/CAS 629-80-1
type: UnificationXref
id: 629-80-1
db: CAS

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Reference/BioCyc PALMITYL-COA
type: UnificationXref
id: PALMITYL-COA
db: BioCyc

Reference/ChemSpider 4446678
type: UnificationXref
id: 4446678
db: ChemSpider

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Reference/ChemSpider 4446673
type: UnificationXref
id: 4446673
db: ChemSpider

Compound/PW C000184/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sphinganine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

ferricytochrome c
type: SmallMolecule
entity reference: ferricytochrome c

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/PubChem-compound 439853
type: UnificationXref
id: 439853
db: PubChem-compound

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Ceramide (d18:1/18:0)
type: SmallMoleculeReference
xref: Reference/ChemSpider 4446678
xref: Reference/KEGG Compound C00195
xref: Reference/CAS 104404-17-3
xref: Reference/PubChem-compound 5283565
xref: Reference/HMDB HMDB0004950
xref: Reference/BioCyc CERAMIDE
xref: Reference/ChEBI CHEBI 72961
chemical formula: C36H71NO3
molecular weight: 565.5434
structure: ChemicalStructure/PW C002313

Reference/PubChem-compound 5353955
type: UnificationXref
id: 5353955
db: PubChem-compound

sphinganine C4-monooxygenase
type: Protein
entity reference: sphinganine C4-monooxygenase

Phosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Phosphate

PC(15:0/18:2(9Z,12Z))
type: SmallMolecule
cellular location: Golgi Apparatus
entity reference: PC(15:0/18:2(9Z,12Z))

Acyl-CoA-dependent ceramide synthase
type: Protein
entity reference: Acyl-CoA-dependent ceramide synthase

Acyl-CoA-dependent ceramide synthase 2
type: Protein
entity reference: Acyl-CoA-dependent ceramide synthase 2

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Reference/BioCyc SER
type: UnificationXref
id: SER
db: BioCyc

Sphingosine
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Sphingosine

ReactionCatalysis6804
type: Catalysis
controller: Unknown
controlled: 3.1.3.-
control type: ACTIVATION

ReactionCatalysis6803
type: Catalysis
controller: Unknown
controlled: 2.7.1.91
control type: ACTIVATION

ReactionCatalysis6802
type: Catalysis
controller: Unknown
controlled: 4.1.2.27
control type: ACTIVATION

Serine palmitoyltransferase 1
type: Protein
cellular location: Cytosol
entity reference: Serine palmitoyltransferase 1

ReactionCatalysis6805
type: Catalysis
controller: Unknown
controlled: 3.1.3.4
control type: ACTIVATION

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

ReactionCatalysis6800
type: Catalysis
controller: Unknown
controlled: 4.1.2.27
control type: ACTIVATION

Compound/PW C001420 Golgi Apparatus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/BioCyc CPD-649
type: UnificationXref
id: CPD-649
db: BioCyc

Reference/ChEBI CHEBI 37550
type: UnificationXref
id: CHEBI:37550
db: ChEBI

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Ceramide (d18:1/18:0)
type: SmallMolecule
cellular location: Golgi Apparatus
entity reference: Ceramide (d18:1/18:0)

Reference/ChEBI CHEBI 15525
type: UnificationXref
id: CHEBI:15525
db: ChEBI

Sphinganine 1-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Sphinganine 1-phosphate

Carbon dioxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbon dioxide

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Reference/ChemSpider 570889
type: UnificationXref
id: 570889
db: ChemSpider

ChemicalStructure/PW C002313
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Phytosphingosine
type: SmallMolecule
entity reference: Phytosphingosine

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Oxygen
type: SmallMolecule
entity reference: Oxygen

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

SM(d18:1/18:0)
type: SmallMoleculeReference
xref: Reference/CAS 85187-10-6
xref: Reference/ChemSpider 4446701
xref: Reference/HMDB HMDB0001348
xref: Reference/BioCyc SPHINGO-MYELIN
xref: Reference/ChEBI CHEBI 17636
xref: Reference/KEGG Compound C00550
xref: Reference/PubChem-compound 5283588
chemical formula: C41H83N2O6P
molecular weight: 730.5989
structure: ChemicalStructure/PW C001040

Compound/PW C000184 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sphinganine
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/BioCyc SPHINGOSINE
type: UnificationXref
id: SPHINGOSINE
db: BioCyc

Reference/CAS 1763-10-6
type: UnificationXref
id: 1763-10-6
db: CAS

Liver
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000759

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Adenosine triphosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Adenosine triphosphate

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Reference/HMDB HMDB0000224
type: UnificationXref
id: HMDB0000224
db: HMDB

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0001551
type: UnificationXref
id: HMDB0001551
db: HMDB

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Reference/UniProt P38703
type: UnificationXref
id: P38703
db: UniProt

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

3-Dehydrosphinganine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 439853
xref: Reference/ChEBI CHEBI 17862
xref: Reference/ChemSpider 388895
xref: Reference/KEGG Compound C02934
xref: Reference/HMDB HMDB0001480
xref: Reference/CAS 16105-69-4
xref: Reference/BioCyc DEHYDROSPHINGANINE
chemical formula: C18H37NO2
molecular weight: 299.28244
structure: ChemicalStructure/PW C001139

Reference/PubChem-compound 5951
type: UnificationXref
id: 5951
db: PubChem-compound

Reference/KEGG Compound C06124
type: UnificationXref
id: C06124
db: KEGG Compound

Reference/HMDB HMDB0001565
type: UnificationXref
id: HMDB0001565
db: HMDB

ChemicalStructure/PW C001202
type: ChemicalStructure
structure format: SMILES
structure data: C[N+](C)(C)CCOP(O)(O)=O

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/HMDB HMDB0004950
type: UnificationXref
id: HMDB0004950
db: HMDB

Sphingosine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 5353955
xref: Reference/KEGG Compound C00319
xref: Reference/BioCyc SPHINGOSINE
xref: Reference/ChEBI CHEBI 16393
xref: Reference/CAS 123-78-4
xref: Reference/ChemSpider 4510275
xref: Reference/HMDB HMDB0000252
chemical formula: C18H37NO2
molecular weight: 299.28244
structure: ChemicalStructure/PW C000172

Reference/ChEBI CHEBI 15754
type: UnificationXref
id: CHEBI:15754
db: ChEBI

Reference/ChEBI CHEBI 15991
type: UnificationXref
id: CHEBI:15991
db: ChEBI

Reference/ChEBI CHEBI 72961
type: UnificationXref
id: CHEBI:72961
db: ChEBI

Palmitoyl-CoA
type: SmallMoleculeReference
xref: Reference/PubChem-compound 15667
xref: Reference/ChemSpider 14902
xref: Reference/HMDB HMDB0001338
xref: Reference/ChEBI CHEBI 15525
xref: Reference/KEGG Compound C00154
xref: Reference/CAS 1763-10-6
xref: Reference/BioCyc PALMITYL-COA
chemical formula: C37H66N7O17P3S
molecular weight: 1005.34485
structure: ChemicalStructure/PW C001031

ChemicalStructure/PW C000120
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CO)C(O)=O

Sphinganine
type: SmallMolecule
entity reference: Sphinganine

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Compound/PW C000188 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sphingosine 1-phosphate
stoichiometric coefficient: 1.0

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

ChemicalStructure/PW C003990
type: ChemicalStructure
structure format: SMILES
structure data: CCCCCCCCCCCCCCC(=O)OC[C@]([H])(COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC

Reference/HMDB HMDB0001338
type: UnificationXref
id: HMDB0001338
db: HMDB

Reference/SMPDB SMP0002378
type: UnificationXref
id: SMP0002378
db: SMPDB

Sphingosine 1-phosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000277
xref: Reference/ChEBI CHEBI 37550
xref: Reference/KEGG Compound C06124
xref: Reference/PubChem-compound 5283560
xref: Reference/ChemSpider 4446673
xref: Reference/CAS 26993-30-6
chemical formula: C18H38NO5P
molecular weight: 379.24875
structure: ChemicalStructure/PW C000188

Reference/ChemSpider 4510275
type: UnificationXref
id: 4510275
db: ChemSpider

Sphinganine
type: SmallMoleculeReference
xref: Reference/CAS 764-22-7
xref: Reference/ChEBI CHEBI 16566
xref: Reference/HMDB HMDB0000269
xref: Reference/KEGG Compound C00836
xref: Reference/PubChem-compound 91486
xref: Reference/ChemSpider 82609
chemical formula: C18H39NO2
molecular weight: 301.29807
structure: ChemicalStructure/PW C000184

Reference/ChEBI CHEBI 17862
type: UnificationXref
id: CHEBI:17862
db: ChEBI

Reference/KEGG Compound C00836
type: UnificationXref
id: C00836
db: KEGG Compound

Endoplasmic Reticulum
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005783

Endoplasmic Reticulum Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005789

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

ChemicalStructure/PW C002905
type: ChemicalStructure
structure format: SMILES
structure data: CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC=O

Reference/ChEBI CHEBI 16893
type: UnificationXref
id: CHEBI:16893
db: ChEBI

Adenosine diphosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Adenosine diphosphate

Reference/CAS 764-22-7
type: UnificationXref
id: 764-22-7
db: CAS

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

Reference/PubChem-compound 91486
type: UnificationXref
id: 91486
db: PubChem-compound

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Reference/ChEBI CHEBI 17636
type: UnificationXref
id: CHEBI:17636
db: ChEBI

Reference/ChemSpider 82609
type: UnificationXref
id: 82609
db: ChemSpider

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Coenzyme A
type: SmallMolecule
entity reference: Coenzyme A

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine diphosphate

Reference/KEGG Compound C05183
type: UnificationXref
id: C05183
db: KEGG Compound

Golgi Apparatus
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005794

Reference/CAS 123-78-4
type: UnificationXref
id: 123-78-4
db: CAS

Reference/GENE ONTOLOGY GO 0005794
type: UnificationXref
id: GO:0005794
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 17600
type: UnificationXref
id: CHEBI:17600
db: ChEBI

Reference/ChemSpider 14902
type: UnificationXref
id: 14902
db: ChemSpider

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

Compound/PW C001034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Reference/GENE ONTOLOGY GO 0005789
type: UnificationXref
id: GO:0005789
db: GENE ONTOLOGY

Reference/ChemSpider 108921
type: UnificationXref
id: 108921
db: ChemSpider

Reference/GENE ONTOLOGY GO 0005783
type: UnificationXref
id: GO:0005783
db: GENE ONTOLOGY

Phytosphingosine
type: SmallMoleculeReference
xref: Reference/CAS 554-62-1
xref: Reference/HMDB HMDB0004610
xref: Reference/BioCyc PHYTOSPINGOSINE
xref: Reference/ChemSpider 108921
xref: Reference/KEGG Compound C12144
xref: Reference/ChEBI CHEBI 46961
xref: Reference/PubChem-compound 122121
chemical formula: C18H39NO3
molecular weight: 317.293
structure: ChemicalStructure/PW C002151

O-Phosphoethanolamine
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: O-Phosphoethanolamine

Reference/CAS 85187-10-6
type: UnificationXref
id: 85187-10-6
db: CAS

Reference/ChemSpider 4446701
type: UnificationXref
id: 4446701
db: ChemSpider

Compound/PW C001099/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Unknown
type: Protein
cellular location: Cytosol
entity reference: Unknown

Sphinganine 1-phosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644260
xref: Reference/ChemSpider 559277
xref: Reference/KEGG Compound C01120
xref: Reference/HMDB HMDB0001383
xref: Reference/CAS 19794-97-9
xref: Reference/ChEBI CHEBI 16893
xref: Reference/BioCyc CPD-649
chemical formula: C18H40NO5P
molecular weight: 381.2644
structure: ChemicalStructure/PW C001070

Palmitaldehyde
type: SmallMoleculeReference
xref: Reference/PubChem-compound 984
xref: Reference/ChEBI CHEBI 17600
xref: Reference/KEGG Compound C00517
xref: Reference/ChemSpider 959
xref: Reference/HMDB HMDB0001551
xref: Reference/CAS 629-80-1
xref: Reference/BioCyc PALMITALDEHYDE
chemical formula: C16H32O
molecular weight: 240.24532
structure: ChemicalStructure/PW C001193

Palmitaldehyde
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Palmitaldehyde

Reference/KEGG Compound C02934
type: UnificationXref
id: C02934
db: KEGG Compound

Reference/KEGG Compound C00517
type: UnificationXref
id: C00517
db: KEGG Compound

Reference/CAS 26993-30-6
type: UnificationXref
id: 26993-30-6
db: CAS

Compound/PW C000149 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: O-Phosphoethanolamine
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0012947
type: UnificationXref
id: HMDB0012947
db: HMDB

ChemicalStructure/PW C008134
type: ChemicalStructure
structure format: SMILES

ReactionCatalysis6811
type: Catalysis
controller: Unknown
controlled: 3.1.4.12
control type: ACTIVATION

L-Serine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Serine

ReactionCatalysis6810
type: Catalysis
controller: Unknown
controlled: 2.7.8.27
control type: ACTIVATION

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Unknown
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: Unknown

Succinyl-CoA
type: SmallMolecule
entity reference: Succinyl-CoA

3-Dehydrosphinganine
type: SmallMolecule
cellular location: Cytosol
entity reference: 3-Dehydrosphinganine

Reference/CAS 56-45-1
type: UnificationXref
id: 56-45-1
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

ferricytochrome c
type: SmallMoleculeReference
xref: Reference/PubChem-compound 3425
xref: Reference/ChEBI CHEBI 15991
chemical formula: C42H68O13
molecular weight: 780.466
structure: ChemicalStructure/PW C040779

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Reference/ChEBI CHEBI 17553
type: UnificationXref
id: CHEBI:17553
db: ChEBI

ReactionCatalysis6825
type: Catalysis
controller: sphinganine C4-monooxygenase
controlled: 1.-.-.-
control type: ACTIVATION

ReactionCatalysis6824
type: Catalysis
controller: Acyl-CoA-dependent ceramide synthase
controlled: 2.3.1.24
control type: ACTIVATION

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

ReactionCatalysis6823
type: Catalysis
controller: Unknown
controlled: 3.5.1.-
control type: ACTIVATION

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Compound/PW C000184 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sphinganine
stoichiometric coefficient: 1.0

Reference/ChemSpider 24766615
type: UnificationXref
id: 24766615
db: ChemSpider

ChemicalStructure/PW C002928
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc 3-METHYLBENZYLSUCCINYL-COA
type: UnificationXref
id: 3-METHYLBENZYLSUCCINYL-COA
db: BioCyc

Reference/PubChem-compound 15667
type: UnificationXref
id: 15667
db: PubChem-compound

Compound/PW C002928 Golgi Apparatus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Galactosylglycerol
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/ChEBI CHEBI 16566
type: UnificationXref
id: CHEBI:16566
db: ChEBI

Compound/PW C040779/Stoichiometry/1.0
type: Stoichiometry
physical entity: ferricytochrome c
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Compound/PW C001070 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sphinganine 1-phosphate
stoichiometric coefficient: 1.0

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS