Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/ChemSpider 388357
type: UnificationXref
id: 388357
db: ChemSpider

Reference/TAXONOMY 3702
type: UnificationXref
id: 3702
db: TAXONOMY

Reference/ChEBI CHEBI 15603
type: UnificationXref
id: CHEBI:15603
db: ChEBI

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/UniProt Q9LDD8
type: UnificationXref
id: Q9LDD8
db: UniProt

NADH
type: SmallMolecule
entity reference: NADH

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/ChemSpider 50
type: UnificationXref
id: 50
db: ChemSpider

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

3-Methylglutaconyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc TRANS-3-METHYL-GLUTACONYL-COA
xref: Reference/HMDB HMDB0001057
xref: Reference/KEGG Compound C03231
xref: Reference/ChEBI CHEBI 15488
xref: Reference/CAS 6247-73-0
xref: Reference/ChemSpider 11471767
xref: Reference/PubChem-compound 5462214
chemical formula: C27H42N7O19P3S
molecular weight: 893.1469
structure: ChemicalStructure/PW C000832

NAD
type: SmallMolecule
entity reference: NAD

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial
type: Protein
entity reference: Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial
type: Protein
entity reference: Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

Probable enoyl-CoA hydratase 2, mitochondrial
type: Protein
entity reference: Probable enoyl-CoA hydratase 2, mitochondrial

Hydroxymethylglutaryl-CoA lyase, mitochondrial
type: Protein
entity reference: Hydroxymethylglutaryl-CoA lyase, mitochondrial

Acetoacetic acid
type: SmallMolecule
entity reference: Acetoacetic acid

Compound/PW C000095/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Compound/PW C000414/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Reference/PubChem-compound 51
type: UnificationXref
id: 51
db: PubChem-compound

Reference/ChemSpider 11471767
type: UnificationXref
id: 11471767
db: ChemSpider

ChemicalStructure/PW C000463
type: ChemicalStructure
structure format: SMILES
structure data: OC(O)=O

Reference/UniProt Q9FYA6
type: UnificationXref
id: Q9FYA6
db: UniProt

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Acetoacetic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15344
xref: Reference/HMDB HMDB0000060
xref: Reference/BioCyc 3-KETOBUTYRATE
xref: Reference/KEGG Compound C00164
xref: Reference/PubChem-compound 96
xref: Reference/CAS 541-50-4
xref: Reference/ChemSpider 94
chemical formula: C4H6O3
molecular weight: 102.03169
structure: ChemicalStructure/PW C000042

Reference/UniProt Q9M7Z1
type: UnificationXref
id: Q9M7Z1
db: UniProt

Reference/CAS 1553-55-5
type: UnificationXref
id: 1553-55-5
db: CAS

Compound/PW C001034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/BioCyc HCO3
type: UnificationXref
id: HCO3
db: BioCyc

ChemicalStructure/PW C000547
type: ChemicalStructure
structure format: SMILES
structure data: CC(C)CC(=O)C(O)=O

Dihydrolipoyl dehydrogenase 2, mitochondrial
type: Protein
entity reference: Dihydrolipoyl dehydrogenase 2, mitochondrial

Compound/PW C000940/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

2-oxoisovalerate dehydrogenase subunit alpha 2, mitochondrial
type: Protein
entity reference: 2-oxoisovalerate dehydrogenase subunit alpha 2, mitochondrial

2-oxoisovalerate dehydrogenase subunit beta 2, mitochondrial
type: Protein
entity reference: 2-oxoisovalerate dehydrogenase subunit beta 2, mitochondrial

Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial
type: Protein
entity reference: Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

3-Methylglutaconyl-CoA
type: SmallMolecule
entity reference: 3-Methylglutaconyl-CoA

Branched-chain-amino-acid aminotransferase 2, chloroplastic
type: Protein
entity reference: Branched-chain-amino-acid aminotransferase 2, chloroplastic

Reference/ChEBI CHEBI 48430
type: UnificationXref
id: CHEBI:48430
db: ChEBI

Branched-chain-amino-acid aminotransferase 3, chloroplastic
type: Protein
entity reference: Branched-chain-amino-acid aminotransferase 3, chloroplastic

Branched-chain-amino-acid aminotransferase 5, chloroplastic
type: Protein
entity reference: Branched-chain-amino-acid aminotransferase 5, chloroplastic

Reference/UniProt Q9M401
type: UnificationXref
id: Q9M401
db: UniProt

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Oxoglutaric acid
type: SmallMoleculeReference
xref: Reference/CAS 328-50-7
xref: Reference/PubChem-compound 51
xref: Reference/BioCyc 2-KETOGLUTARATE
xref: Reference/HMDB HMDB0000208
xref: Reference/ChEBI CHEBI 30915
xref: Reference/KEGG Compound C00026
xref: Reference/ChemSpider 50
chemical formula: C5H6O5
molecular weight: 146.02153
structure: ChemicalStructure/PW C000134

4.1.3.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000940/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000042/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001063/Stoichiometry/1.0
right: Acetoacetic acid
right: Acetyl-CoA
spontaneous: false
EC number: 4.1.3.4
left: 3-Hydroxy-3-methylglutaryl-CoA
name: 3-Hydroxy-3-methylglutaryl-CoA → Acetoacetic acid + Acetyl-CoA
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 439855
type: UnificationXref
id: 439855
db: PubChem-compound

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Protein/Generic37/Stoichiometry/1.0
type: Stoichiometry
physical entity: Reduced flavoprotein
stoichiometric coefficient: 1.0

Reaction7250
type: BiochemicalReaction
participant stoichiometry: Protein/Generic37/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001150/Stoichiometry/1.0
participant stoichiometry: Protein/Generic38/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000870/Stoichiometry/1.0
right: 3-Methylcrotonyl-CoA
right: Reduced flavoprotein
spontaneous: false
left: Isovaleryl-CoA
left: Oxidized flavoprotein
name: Isovaleryl-CoA + Oxidized flavoprotein → 3-Methylcrotonyl-CoA + Reduced flavoprotein
conversion direction: LEFT_TO_RIGHT

4.2.1.17
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000832/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001063/Stoichiometry/1.0
right: 3-Hydroxy-3-methylglutaryl-CoA
spontaneous: false
EC number: 4.2.1.17
left: Water
left: 3-Methylglutaconyl-CoA
name: 3-Methylglutaconyl-CoA + Water → 3-Hydroxy-3-methylglutaryl-CoA
conversion direction: LEFT_TO_RIGHT

6.4.1.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000832/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000463/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001150/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
right: Adenosine diphosphate
right: Hydrogen Ion
right: Phosphate
right: 3-Methylglutaconyl-CoA
spontaneous: false
EC number: 6.4.1.4
left: 3-Methylcrotonyl-CoA
left: Hydrogen carbonate
left: Adenosine triphosphate
name: 3-Methylcrotonyl-CoA + Adenosine triphosphate + Hydrogen carbonate → 3-Methylglutaconyl-CoA + Adenosine diphosphate + Hydrogen Ion + Phosphate
conversion direction: LEFT_TO_RIGHT

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Acetyl-CoA
type: SmallMolecule
entity reference: Acetyl-CoA

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

Branched-chain-amino-acid aminotransferase 1, mitochondrial
type: Protein
entity reference: Branched-chain-amino-acid aminotransferase 1, mitochondrial

Reference/HMDB HMDB0000687
type: UnificationXref
id: HMDB0000687
db: HMDB

Reference/ChemSpider 69
type: UnificationXref
id: 69
db: ChemSpider

Reference/PubChem-compound 70
type: UnificationXref
id: 70
db: PubChem-compound

Reaction7242
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000095/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000547/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000540/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134/Stoichiometry/1.0
right: L-Glutamic acid
right: Ketoleucine
spontaneous: false
left: Oxoglutaric acid
left: L-Leucine
name: L-Leucine + Oxoglutaric acid → Ketoleucine + L-Glutamic acid
conversion direction: LEFT_TO_RIGHT

Compound/PW C000870/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isovaleryl-CoA
stoichiometric coefficient: 1.0

2.6.1.42,2.6.1.88
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000095/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000547/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000540/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134/Stoichiometry/1.0
right: L-Glutamic acid
right: Ketoleucine
spontaneous: false
EC number: 2.6.1.42,2.6.1.88
left: Oxoglutaric acid
left: L-Leucine
name: L-Leucine + Oxoglutaric acid → Ketoleucine + L-Glutamic acid
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 388909
type: UnificationXref
id: 388909
db: ChemSpider

Compound/PW C000042/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetoacetic acid
stoichiometric coefficient: 1.0

2.6.1.42
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000095/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000547/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000540/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134/Stoichiometry/1.0
right: L-Glutamic acid
right: Ketoleucine
spontaneous: false
EC number: 2.6.1.42
left: Oxoglutaric acid
left: L-Leucine
name: L-Leucine + Oxoglutaric acid → Ketoleucine + L-Glutamic acid
conversion direction: LEFT_TO_RIGHT

Reaction7249
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000547/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000870/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144/Stoichiometry/1.0
right: NADH
right: Isovaleryl-CoA
right: Carbon dioxide
spontaneous: false
left: Coenzyme A
left: NAD
left: Ketoleucine
name: Coenzyme A + Ketoleucine + NAD → Carbon dioxide + Isovaleryl-CoA + NADH
conversion direction: LEFT_TO_RIGHT

2.6.1.42
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000095/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000547/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000540/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134/Stoichiometry/1.0
right: L-Glutamic acid
right: Ketoleucine
spontaneous: false
EC number: 2.6.1.42
left: Oxoglutaric acid
left: L-Leucine
name: L-Leucine + Oxoglutaric acid → Ketoleucine + L-Glutamic acid
conversion direction: LEFT_TO_RIGHT

Hydroxymethylglutaryl-CoA lyase, mitochondrial
type: ProteinReference
xref: Reference/UniProt O81027

Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q42523

Reference/UniProt Q93Y32
type: UnificationXref
id: Q93Y32
db: UniProt

Branched-chain-amino-acid aminotransferase 5, chloroplastic
type: ProteinReference
xref: Reference/UniProt Q9FYA6

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

Probable enoyl-CoA hydratase 2, mitochondrial
type: ProteinReference
xref: Reference/UniProt F4JML5

Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q9LDD8

Reference/HMDB HMDB0000208
type: UnificationXref
id: HMDB0000208
db: HMDB

Reference/PubChem-compound 6106
type: UnificationXref
id: 6106
db: PubChem-compound

Branched-chain-amino-acid aminotransferase 3, chloroplastic
type: ProteinReference
xref: Reference/UniProt Q9M401

Branched-chain-amino-acid aminotransferase 2, chloroplastic
type: ProteinReference
xref: Reference/UniProt Q9M439

Reference/ChEBI CHEBI 5086
type: UnificationXref
id: CHEBI:5086
db: ChEBI

Reference/KEGG Compound C00356
type: UnificationXref
id: C00356
db: KEGG Compound

Reference/KEGG Compound C03069
type: UnificationXref
id: C03069
db: KEGG Compound

Reference/ChemSpider 5880
type: UnificationXref
id: 5880
db: ChemSpider

Reference/KEGG Compound C00233
type: UnificationXref
id: C00233
db: KEGG Compound

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

Reference/HMDB HMDB0000695
type: UnificationXref
id: HMDB0000695
db: HMDB

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

L-Glutamic acid
type: SmallMolecule
entity reference: L-Glutamic acid

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial
type: Complex
component: Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial
component: Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

Compound/PW C000463/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen carbonate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

3-Hydroxy-3-methylglutaryl-CoA
type: SmallMolecule
entity reference: 3-Hydroxy-3-methylglutaryl-CoA

ChemicalStructure/PW C000134
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(=O)C(O)=O

Reference/ChEBI CHEBI 30915
type: UnificationXref
id: CHEBI:30915
db: ChEBI

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Isovaleryl-CoA
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001113
xref: Reference/ChEBI CHEBI 15487
xref: Reference/ChemSpider 388897
xref: Reference/KEGG Compound C02939
xref: Reference/BioCyc ISOVALERYL-COA
xref: Reference/CAS 6244-91-3
xref: Reference/PubChem-compound 439855
chemical formula: C26H44N7O17P3S
molecular weight: 851.1727
structure: ChemicalStructure/PW C000870

Reference/ChemSpider 94
type: UnificationXref
id: 94
db: ChemSpider

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Compound/PW C000540/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Leucine
stoichiometric coefficient: 1.0

Reference/BioCyc LEU
type: UnificationXref
id: LEU
db: BioCyc

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00123
type: UnificationXref
id: C00123
db: KEGG Compound

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

Reference/PubChem-compound 439869
type: UnificationXref
id: 439869
db: PubChem-compound

Reference/PubChem-compound 5462214
type: UnificationXref
id: 5462214
db: PubChem-compound

Reference/ChemSpider 388897
type: UnificationXref
id: 388897
db: ChemSpider

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Leucine Degradation
type: Pathway
pathway order: PathwayEnzymeReaction/26648
pathway order: PathwayEnzymeReaction/26649
pathway order: PathwayEnzymeReaction/26650
pathway order: PathwayEnzymeReaction/26652
pathway order: PathwayEnzymeReaction/26653
pathway order: PathwayEnzymeReaction/26654
pathway order: PathwayEnzymeReaction/26655
pathway order: PathwayEnzymeReaction/26646
pathway order: PathwayEnzymeReaction/26647
pathway component: ReactionCatalysis7232
pathway component: Reaction7250
pathway component: 4.2.1.17
pathway component: 6.4.1.4
pathway component: ReactionCatalysis7236
pathway component: Reaction7242
pathway component: ReactionCatalysis7235
pathway component: 4.1.3.4
pathway component: ReactionCatalysis7234
pathway component: ReactionCatalysis7233
pathway component: 2.6.1.42,2.6.1.88
pathway component: ReactionCatalysis7228
pathway component: 2.6.1.42
pathway component: Reaction7249
pathway component: ReactionCatalysis7238
pathway component: ReactionCatalysis7237
xref: Reference/PathWhiz PW002541
xref: Reference/SMPDB SMP0002433
organism: Arabidopsis thaliana

Reference/HMDB HMDB0000595
type: UnificationXref
id: HMDB0000595
db: HMDB

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Isovaleryl-CoA
type: SmallMolecule
entity reference: Isovaleryl-CoA

Reduced flavoprotein
type: Protein
entity reference: Reduced flavoprotein

Compound/PW C000547/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ketoleucine
stoichiometric coefficient: 1.0

Oxidized flavoprotein
type: Protein
entity reference: Oxidized flavoprotein

Reference/BioCyc 3-HYDROXY-3-METHYL-GLUTARYL-COA
type: UnificationXref
id: 3-HYDROXY-3-METHYL-GLUTARYL-COA
db: BioCyc

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/KEGG Compound C00026
type: UnificationXref
id: C00026
db: KEGG Compound

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

Reference/BioCyc TRANS-3-METHYL-GLUTACONYL-COA
type: UnificationXref
id: TRANS-3-METHYL-GLUTACONYL-COA
db: BioCyc

Adenosine diphosphate
type: SmallMolecule
entity reference: Adenosine diphosphate

3-Methylcrotonyl-CoA
type: SmallMolecule
entity reference: 3-Methylcrotonyl-CoA

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

3-Methylcrotonyl-CoA
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15486
xref: Reference/CAS 793193-48-3
xref: Reference/PubChem-compound 439869
xref: Reference/BioCyc 3-METHYL-CROTONYL-COA
xref: Reference/ChemSpider 388909
xref: Reference/HMDB HMDB0001493
xref: Reference/KEGG Compound C03069
chemical formula: C26H42N7O17P3S
molecular weight: 849.15704
structure: ChemicalStructure/PW C001150

Ketoleucine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000695
xref: Reference/ChEBI CHEBI 48430
xref: Reference/ChemSpider 69
xref: Reference/PubChem-compound 70
xref: Reference/BioCyc 2K-4CH3-PENTANOATE
xref: Reference/CAS 816-66-0
xref: Reference/KEGG Compound C00233
chemical formula: C6H10O3
molecular weight: 130.06299
structure: ChemicalStructure/PW C000547

Compound/PW C000721/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/PubChem-compound 769
type: UnificationXref
id: 769
db: PubChem-compound

Reference/CAS 793193-48-3
type: UnificationXref
id: 793193-48-3
db: CAS

Reference/BioCyc 3-KETOBUTYRATE
type: UnificationXref
id: 3-KETOBUTYRATE
db: BioCyc

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Reference/CAS 328-50-7
type: UnificationXref
id: 328-50-7
db: CAS

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

Water
type: SmallMolecule
entity reference: Water

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Reference/BioCyc 3-METHYL-CROTONYL-COA
type: UnificationXref
id: 3-METHYL-CROTONYL-COA
db: BioCyc

Reference/KEGG Compound C00164
type: UnificationXref
id: C00164
db: KEGG Compound

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

Reference/KEGG Compound C00288
type: UnificationXref
id: C00288
db: KEGG Compound

Coenzyme A
type: SmallMolecule
entity reference: Coenzyme A

Reference/HMDB HMDB0001113
type: UnificationXref
id: HMDB0001113
db: HMDB

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

Reference/SMPDB SMP0002433
type: UnificationXref
id: SMP0002433
db: SMPDB

ChemicalStructure/PW C001150
type: ChemicalStructure
structure format: SMILES

Compound/PW C000832/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Methylglutaconyl-CoA
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

Arabidopsis thaliana
type: BioSource
xref: Reference/TAXONOMY 3702

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

3-Hydroxy-3-methylglutaryl-CoA
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15467
xref: Reference/ChemSpider 388357
xref: Reference/CAS 1553-55-5
xref: Reference/BioCyc 3-HYDROXY-3-METHYL-GLUTARYL-COA
xref: Reference/KEGG Compound C00356
xref: Reference/HMDB HMDB0001375
xref: Reference/PubChem-compound 439218
chemical formula: C27H44N7O20P3S
molecular weight: 911.1575
structure: ChemicalStructure/PW C001063

Compound/PW C001316/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Reference/PubChem-compound 439218
type: UnificationXref
id: 439218
db: PubChem-compound

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

Dihydrolipoyl dehydrogenase 2, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q9M5K2

Reference/UniProt Q84JL2
type: UnificationXref
id: Q84JL2
db: UniProt

Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q9M7Z1

Reference/UniProt Q42523
type: UnificationXref
id: Q42523
db: UniProt

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

2-oxoisovalerate dehydrogenase subunit beta 2, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q9LDY2

Compound/PW C001099/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

2-oxoisovalerate dehydrogenase subunit alpha 2, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q84JL2

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

ChemicalStructure/PW C000832
type: ChemicalStructure
structure format: SMILES

Branched-chain-amino-acid aminotransferase 1, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q93Y32

Compound/PW C001144/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Compound/PW C000134/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxoglutaric acid
stoichiometric coefficient: 1.0

Reference/CAS 816-66-0
type: UnificationXref
id: 816-66-0
db: CAS

Reference/UniProt Q9M5K2
type: UnificationXref
id: Q9M5K2
db: UniProt

Ketoleucine
type: SmallMolecule
entity reference: Ketoleucine

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

branched-chain keto-acid dehydrogenase complex
type: Complex
component: Dihydrolipoyl dehydrogenase 2, mitochondrial
component: 2-oxoisovalerate dehydrogenase subunit alpha 2, mitochondrial
component: 2-oxoisovalerate dehydrogenase subunit beta 2, mitochondrial
component: Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

ChemicalStructure/PW C000042
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)CC(O)=O

L-Leucine
type: SmallMolecule
entity reference: L-Leucine

Reference/BioCyc 2K-4CH3-PENTANOATE
type: UnificationXref
id: 2K-4CH3-PENTANOATE
db: BioCyc

L-Leucine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000687
xref: Reference/ChEBI CHEBI 15603
xref: Reference/CAS 61-90-5
xref: Reference/BioCyc LEU
xref: Reference/PubChem-compound 6106
xref: Reference/KEGG Compound C00123
xref: Reference/ChemSpider 5880
chemical formula: C6H13NO2
molecular weight: 131.09464
structure: ChemicalStructure/PW C000540

Reference/HMDB HMDB0001493
type: UnificationXref
id: HMDB0001493
db: HMDB

Reference/HMDB HMDB0001375
type: UnificationXref
id: HMDB0001375
db: HMDB

Reference/ChEBI CHEBI 15487
type: UnificationXref
id: CHEBI:15487
db: ChEBI

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChEBI CHEBI 15486
type: UnificationXref
id: CHEBI:15486
db: ChEBI

Reference/KEGG Compound C02939
type: UnificationXref
id: C02939
db: KEGG Compound

Reference/ChEBI CHEBI 17544
type: UnificationXref
id: CHEBI:17544
db: ChEBI

Reference/ChEBI CHEBI 15488
type: UnificationXref
id: CHEBI:15488
db: ChEBI

Reference/BioCyc ISOVALERYL-COA
type: UnificationXref
id: ISOVALERYL-COA
db: BioCyc

Reference/BioCyc 2-KETOGLUTARATE
type: UnificationXref
id: 2-KETOGLUTARATE
db: BioCyc

Protein/Generic38/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxidized flavoprotein
stoichiometric coefficient: 1.0

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

Reference/CAS 61-90-5
type: UnificationXref
id: 61-90-5
db: CAS

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Phosphate
type: SmallMolecule
entity reference: Phosphate

Reference/UniProt Q9LDY2
type: UnificationXref
id: Q9LDY2
db: UniProt

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reduced flavoprotein
type: ProteinReference
xref: Reference/ChEBI CHEBI 5086

Compound/PW C001104/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Oxidized flavoprotein
type: ProteinReference
xref: Reference/ChEBI CHEBI 5086

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reference/KEGG Compound C03231
type: UnificationXref
id: C03231
db: KEGG Compound

Oxoglutaric acid
type: SmallMolecule
entity reference: Oxoglutaric acid

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

ChemicalStructure/PW C001063
type: ChemicalStructure
structure format: SMILES

ReactionCatalysis7228
type: Catalysis
controller: Branched-chain-amino-acid aminotransferase 1, mitochondrial
controlled: Reaction7242
control type: ACTIVATION

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

ReactionCatalysis7232
type: Catalysis
controller: Branched-chain-amino-acid aminotransferase 2, chloroplastic
controlled: 2.6.1.42
control type: ACTIVATION

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Reference/CAS 6247-73-0
type: UnificationXref
id: 6247-73-0
db: CAS

ChemicalStructure/PW C000540
type: ChemicalStructure
structure format: SMILES
structure data: CC(C)C[C@H](N)C(O)=O

ReactionCatalysis7236
type: Catalysis
controller: Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial
controlled: 6.4.1.4
control type: ACTIVATION

Reference/HMDB HMDB0000060
type: UnificationXref
id: HMDB0000060
db: HMDB

ReactionCatalysis7235
type: Catalysis
controller: branched-chain keto-acid dehydrogenase complex
controlled: Reaction7249
control type: ACTIVATION

ReactionCatalysis7234
type: Catalysis
controller: Branched-chain-amino-acid aminotransferase 5, chloroplastic
controlled: 2.6.1.42
control type: ACTIVATION

Reference/PubChem-compound 96
type: UnificationXref
id: 96
db: PubChem-compound

ReactionCatalysis7233
type: Catalysis
controller: Branched-chain-amino-acid aminotransferase 3, chloroplastic
controlled: 2.6.1.42,2.6.1.88
control type: ACTIVATION

ReactionCatalysis7238
type: Catalysis
controller: Hydroxymethylglutaryl-CoA lyase, mitochondrial
controlled: 4.1.3.4
control type: ACTIVATION

ReactionCatalysis7237
type: Catalysis
controller: Probable enoyl-CoA hydratase 2, mitochondrial
controlled: 4.2.1.17
control type: ACTIVATION

Reference/ChEBI CHEBI 15344
type: UnificationXref
id: CHEBI:15344
db: ChEBI

Reference/ChEBI CHEBI 15467
type: UnificationXref
id: CHEBI:15467
db: ChEBI

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

Reference/PathWhiz PW002541
type: UnificationXref
id: PW002541
db: PathWhiz

Reference/UniProt Q9M439
type: UnificationXref
id: Q9M439
db: UniProt

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

Reference/UniProt F4JML5
type: UnificationXref
id: F4JML5
db: UniProt

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Compound/PW C001150/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Methylcrotonyl-CoA
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000870
type: ChemicalStructure
structure format: SMILES

Reference/CAS 541-50-4
type: UnificationXref
id: 541-50-4
db: CAS

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Carbon dioxide
type: SmallMolecule
entity reference: Carbon dioxide

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/ChemSpider 749
type: UnificationXref
id: 749
db: ChemSpider

Reference/CAS 71-52-3
type: UnificationXref
id: 71-52-3
db: CAS

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

Compound/PW C001063/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Hydroxy-3-methylglutaryl-CoA
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001057
type: UnificationXref
id: HMDB0001057
db: HMDB

Reference/CAS 6244-91-3
type: UnificationXref
id: 6244-91-3
db: CAS

Hydrogen carbonate
type: SmallMolecule
entity reference: Hydrogen carbonate

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

Hydrogen carbonate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000595
xref: Reference/ChEBI CHEBI 17544
xref: Reference/PubChem-compound 769
xref: Reference/BioCyc HCO3
xref: Reference/ChemSpider 749
xref: Reference/CAS 71-52-3
xref: Reference/KEGG Compound C00288
chemical formula: CH2O3
molecular weight: 62.000393
structure: ChemicalStructure/PW C000463

Reference/UniProt O81027
type: UnificationXref
id: O81027
db: UniProt