Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/KEGG Compound C02737
type: UnificationXref
id: C02737
db: KEGG Compound

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/KEGG Compound C00670
type: UnificationXref
id: C00670
db: KEGG Compound

Compound/PW C005005/Stoichiometry/1.0
type: Stoichiometry
physical entity: PE(16:1(9Z)/16:1(9Z))
stoichiometric coefficient: 1.0

Reference/PubChem-compound 439162
type: UnificationXref
id: 439162
db: PubChem-compound

Reference/HMDB HMDB0000095
type: UnificationXref
id: HMDB0000095
db: HMDB

Reference/ChEBI CHEBI 84299
type: UnificationXref
id: CHEBI:84299
db: ChEBI

Reference/HMDB HMDB0000097
type: UnificationXref
id: HMDB0000097
db: HMDB

LysoPC(16:1(9Z)/0:0)
type: SmallMolecule
entity reference: LysoPC(16:1(9Z)/0:0)

Reference/HMDB HMDB0001185
type: UnificationXref
id: HMDB0001185
db: HMDB

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Compound/PW C045277 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lyso-PS(0:0/14:0)
stoichiometric coefficient: 1.0

Reference/UniProt P05375
type: UnificationXref
id: P05375
db: UniProt

Reference/UniProt P05374
type: UnificationXref
id: P05374
db: UniProt

Reference/PubChem-compound 6131
type: UnificationXref
id: 6131
db: PubChem-compound

Reference/ChemSpider 13207
type: UnificationXref
id: 13207
db: ChemSpider

Compound/PW C000064/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cytidine monophosphate
stoichiometric coefficient: 1.0

Phosphatidyl-N-methylethanolamine N-methyltransferase
type: Protein
entity reference: Phosphatidyl-N-methylethanolamine N-methyltransferase

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Phospholipid-transporting ATPase DNF1
type: Protein
cellular location: Cell Membrane
entity reference: Phospholipid-transporting ATPase DNF1

Phosphatidylethanolamine N-methyltransferase
type: Protein
entity reference: Phosphatidylethanolamine N-methyltransferase

Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

ChemicalStructure/PW C003179
type: ChemicalStructure
structure format: SMILES
structure data: [H][C@](CO)(COC(=O)CCCCCCC\C=C/CCCCCC)OC(=O)CCCCCCC\C=C/CCCCCC

Compound/PW C000065/Stoichiometry/1.0
type: Stoichiometry
physical entity: Choline
stoichiometric coefficient: 1.0

Reference/PubChem-compound 24778764
type: UnificationXref
id: 24778764
db: PubChem-compound

S-Adenosylmethionine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24762165
xref: Reference/KEGG Compound C00019
xref: Reference/ChemSpider 31983
xref: Reference/ChEBI CHEBI 15414
xref: Reference/CAS 485-80-3
xref: Reference/BioCyc S-ADENOSYLMETHIONINE
xref: Reference/HMDB HMDB0001185
chemical formula: C15H23N6O5S
molecular weight: 399.14505
structure: ChemicalStructure/PW C000921

Compound/PW C001034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Compound/PW C043034/Stoichiometry/1.0
type: Stoichiometry
physical entity: CDP-Choline
stoichiometric coefficient: 1.0

Compound/PW C045275 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lyso-PI(14:0/0:0)
stoichiometric coefficient: 1.0

ReactionCoupledTransport215
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C045276 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C045278 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: PI(14:0/14:0)
spontaneous: false
left: Lyso-PI(0:0/14:0)
name: Lyso-PI(0:0/14:0) → PI(14:0/14:0)
conversion direction: LEFT_TO_RIGHT

ReactionCoupledTransport213
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C007860 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C045277 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: PS(14:0/14:0)
spontaneous: false
left: Lyso-PS(0:0/14:0)
name: Lyso-PS(0:0/14:0) → PS(14:0/14:0)
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0008957
type: UnificationXref
id: HMDB0008957
db: HMDB

ReactionCoupledTransport214
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C045278 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
right: Adenosine diphosphate
right: Phosphate
right: Lyso-PI(0:0/14:0)
spontaneous: false
left: Lyso-PI(0:0/14:0)
left: Adenosine triphosphate
left: Water
name: Adenosine triphosphate + Lyso-PI(0:0/14:0) + Water → Adenosine diphosphate + Lyso-PI(0:0/14:0) + Phosphate
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C007860
type: ChemicalStructure
structure format: SMILES

ReactionCoupledTransport211
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C045276 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C045275 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: PI(14:0/14:0)
spontaneous: false
left: Lyso-PI(14:0/0:0)
name: Lyso-PI(14:0/0:0) → PI(14:0/14:0)
conversion direction: LEFT_TO_RIGHT

ReactionCoupledTransport212
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C045277 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
right: Adenosine diphosphate
right: Phosphate
right: Lyso-PS(0:0/14:0)
spontaneous: false
left: Lyso-PS(0:0/14:0)
left: Adenosine triphosphate
left: Water
name: Adenosine triphosphate + Lyso-PS(0:0/14:0) + Water → Adenosine diphosphate + Lyso-PS(0:0/14:0) + Phosphate
conversion direction: LEFT_TO_RIGHT

ReactionCoupledTransport210
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C045275 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
right: Adenosine diphosphate
right: Phosphate
right: Lyso-PI(14:0/0:0)
spontaneous: false
left: Lyso-PI(14:0/0:0)
left: Adenosine triphosphate
left: Water
name: Adenosine triphosphate + Lyso-PI(14:0/0:0) + Water → Adenosine diphosphate + Lyso-PI(14:0/0:0) + Phosphate
conversion direction: LEFT_TO_RIGHT

PC(16:1(9Z)/16:1(9Z))
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24778764
xref: Reference/ChEBI CHEBI 83717
xref: Reference/HMDB HMDB0008002
xref: Reference/KEGG Compound C00157
xref: Reference/BioCyc PHOSPHATIDYLCHOLINE
xref: Reference/ChemSpider 24766671
chemical formula: C40H76NO8P
molecular weight: 729.5309
structure: ChemicalStructure/PW C004051

Reference/ChEBI CHEBI 18303
type: UnificationXref
id: CHEBI:18303
db: ChEBI

Lyso-PS(14:0/0:0)
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Lyso-PS(14:0/0:0)

Reference/ChemSpider 64931
type: UnificationXref
id: 64931
db: ChemSpider

Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00588
type: UnificationXref
id: C00588
db: KEGG Compound

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

ReactionCoupledTransport208
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C045274 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
right: Adenosine diphosphate
right: Phosphate
right: Lyso-PS(14:0/0:0)
spontaneous: false
left: Lyso-PS(14:0/0:0)
left: Adenosine triphosphate
left: Water
name: Adenosine triphosphate + Lyso-PS(14:0/0:0) + Water → Adenosine diphosphate + Lyso-PS(14:0/0:0) + Phosphate
conversion direction: LEFT_TO_RIGHT

Saccharomyces cerevisiae
type: BioSource
xref: Reference/TAXONOMY 4932

ReactionCoupledTransport209
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C007860 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C045274 Endoplasmic Reticulum/Stoichiometry/2.0
right: PS(14:0/14:0)
spontaneous: false
left: Lyso-PS(14:0/0:0)
name: 2 Lyso-PS(14:0/0:0) → PS(14:0/14:0)
conversion direction: LEFT_TO_RIGHT

ReactionCoupledTransport207
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007097 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
right: LysoPE(14:0/0:0)
right: Adenosine diphosphate
right: Phosphate
spontaneous: false
left: LysoPE(14:0/0:0)
left: Adenosine triphosphate
left: Water
name: Adenosine triphosphate + LysoPE(14:0/0:0) + Water → Adenosine diphosphate + LysoPE(14:0/0:0) + Phosphate
conversion direction: LEFT_TO_RIGHT

Compound/PW C045278 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lyso-PI(0:0/14:0)
stoichiometric coefficient: 1.0

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Reference/CAS 28319-77-9
type: UnificationXref
id: 28319-77-9
db: CAS

Reference/CAS 63-37-6
type: UnificationXref
id: 63-37-6
db: CAS

Reference/ChemSpider 110272
type: UnificationXref
id: 110272
db: ChemSpider

Reference/ChemSpider 7822629
type: UnificationXref
id: 7822629
db: ChemSpider

Phospholipid-transporting ATPase DNF2
type: Protein
cellular location: Cell Membrane
entity reference: Phospholipid-transporting ATPase DNF2

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

Reference/UniProt Q02979
type: UnificationXref
id: Q02979
db: UniProt

ChemicalStructure/PW C000921
type: ChemicalStructure
structure format: SMILES

Reference/CAS 979-92-0
type: UnificationXref
id: 979-92-0
db: CAS

ReactionCoupledTransportCatalysis254
type: Catalysis
controller: Ale1p acyltransferase
controlled: ReactionCoupledTransport465
control type: ACTIVATION

ReactionCoupledTransportCatalysis252
type: Catalysis
controller: Ale1p acyltransferase
controlled: ReactionCoupledTransport215
control type: ACTIVATION

Reference/KEGG Compound C00350
type: UnificationXref
id: C00350
db: KEGG Compound

ReactionCoupledTransportCatalysis251
type: Catalysis
controller: Phospholipid-transporting ATPase
controlled: ReactionCoupledTransport214
control type: ACTIVATION

ReactionCoupledTransportCatalysis250
type: Catalysis
controller: Ale1p acyltransferase
controlled: ReactionCoupledTransport213
control type: ACTIVATION

Reference/KEGG Compound C00114
type: UnificationXref
id: C00114
db: KEGG Compound

Reference/BioCyc PHOSPHATIDYLCHOLINE
type: UnificationXref
id: PHOSPHATIDYLCHOLINE
db: BioCyc

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

S-Adenosylhomocysteine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 25246222
xref: Reference/ChemSpider 388301
xref: Reference/BioCyc ADENOSYL-HOMO-CYS
xref: Reference/CAS 979-92-0
xref: Reference/KEGG Compound C00021
xref: Reference/ChEBI CHEBI 16680
xref: Reference/HMDB HMDB0000939
chemical formula: C14H20N6O5S
molecular weight: 384.12158
structure: ChemicalStructure/PW C000749

PS(14:0/14:0)
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: PS(14:0/14:0)

Compound/PW C057492/Stoichiometry/1.0
type: Stoichiometry
physical entity: PE-NMe(16:1(9Z)/16:1(9Z))
stoichiometric coefficient: 1.0

ChemicalStructure/PW C004051
type: ChemicalStructure
structure format: SMILES
structure data: [H][C@@](COC(=O)CCCCCCC\C=C/CCCCCC)(COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/CCCCCC

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/BioCyc CDP-CHOLINE
type: UnificationXref
id: CDP-CHOLINE
db: BioCyc

Ale1p acyltransferase
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: Ale1p acyltransferase

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/BioCyc CTP
type: UnificationXref
id: CTP
db: BioCyc

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Phospholipid-transporting ATPase
type: Complex
cellular location: Cell Membrane
component: Phospholipid-transporting ATPase DNF2
component: Alkylphosphocholine resistance protein LEM3
component: Phospholipid-transporting ATPase DNF1

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Compound/PW C007860 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: PS(14:0/14:0)
stoichiometric coefficient: 1.0

PE(16:1(9Z)/16:1(9Z))
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: PE(16:1(9Z)/16:1(9Z))

Mitochondrial Inner Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005743

ReactionCoupledTransport465
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C007097 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C005005 Mitochondrial Inner Membrane/Stoichiometry/1.0
right: PE(16:1(9Z)/16:1(9Z))
spontaneous: false
left: LysoPE(14:0/0:0)
name: LysoPE(14:0/0:0) → PE(16:1(9Z)/16:1(9Z))
conversion direction: LEFT_TO_RIGHT

Reference/UniProt Q12675
type: UnificationXref
id: Q12675
db: UniProt

Reference/KEGG Compound C00019
type: UnificationXref
id: C00019
db: KEGG Compound

Compound/PW C003179/Stoichiometry/1.0
type: Stoichiometry
physical entity: DG(16:1(9Z)/16:1(9Z)/0:0)
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17361
type: UnificationXref
id: CHEBI:17361
db: ChEBI

Reference/PubChem-compound 123699
type: UnificationXref
id: 123699
db: PubChem-compound

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Reference/ChEBI CHEBI 52332
type: UnificationXref
id: CHEBI:52332
db: ChEBI

ChemicalStructure/PW C005005
type: ChemicalStructure
structure format: SMILES

LysoPC(16:1(9Z)/0:0)
type: SmallMoleculeReference
xref: Reference/KEGG Compound C04230
xref: Reference/HMDB HMDB0010383
xref: Reference/CAS 76790-27-7
xref: Reference/ChemSpider 24766525
xref: Reference/PubChem-compound 24779461
xref: Reference/BioCyc PHOSPHATIDYLCHOLINE
xref: Reference/ChEBI CHEBI 73851
chemical formula: C24H48NO7P
molecular weight: 493.31683
structure: ChemicalStructure/PW C006392

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/ChemSpider 388301
type: UnificationXref
id: 388301
db: ChemSpider

S-Adenosylhomocysteine
type: SmallMolecule
entity reference: S-Adenosylhomocysteine

Reference/ChemSpider 388308
type: UnificationXref
id: 388308
db: ChemSpider

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/KEGG Compound C00021
type: UnificationXref
id: C00021
db: KEGG Compound

3.1.4.46
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000081/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000059/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000065/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Hydrogen Ion
right: Choline
right: Glycerol 3-phosphate
spontaneous: false
EC number: 3.1.4.46
left: Water
left: Glycerophosphocholine
name: Glycerophosphocholine + Water → Choline + Glycerol 3-phosphate + Hydrogen Ion
conversion direction: LEFT_TO_RIGHT

Compound/PW C000921/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylmethionine
stoichiometric coefficient: 1.0

Reference/BioCyc PHOSPHORYL-CHOLINE
type: UnificationXref
id: PHOSPHORYL-CHOLINE
db: BioCyc

ReactionCoupledTransport244
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006392 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
right: Adenosine diphosphate
right: Phosphate
right: LysoPC(16:1(9Z)/0:0)
spontaneous: false
left: LysoPC(16:1(9Z)/0:0)
left: Adenosine triphosphate
left: Water
name: Adenosine triphosphate + LysoPC(16:1(9Z)/0:0) + Water → Adenosine diphosphate + LysoPC(16:1(9Z)/0:0) + Phosphate
conversion direction: LEFT_TO_RIGHT

Glycerophosphodiester phosphodiesterase GDE1
type: ProteinReference
xref: Reference/UniProt Q02979

Reference/BioCyc DIACYLGLYCEROL
type: UnificationXref
id: DIACYLGLYCEROL
db: BioCyc

ReactionCatalysis7386
type: Catalysis
controller: Phosphatidyl-N-methylethanolamine N-methyltransferase
controlled: Reaction7545
control type: ACTIVATION

ReactionCatalysis7385
type: Catalysis
controller: Phosphatidyl-N-methylethanolamine N-methyltransferase
controlled: 2.1.1.17,2.1.1.71
control type: ACTIVATION

ReactionCatalysis7384
type: Catalysis
controller: Phosphatidylethanolamine N-methyltransferase
controlled: 2.1.1.17
control type: ACTIVATION

Reference/HMDB HMDB0113849
type: UnificationXref
id: HMDB0113849
db: HMDB

Reference/KEGG Compound C00157
type: UnificationXref
id: C00157
db: KEGG Compound

Water
type: SmallMolecule
entity reference: Water

ChemicalStructure/PW C000059
type: ChemicalStructure
structure format: SMILES
structure data: C[N+](C)(C)CCOP([O-])(=O)OC[C@H](O)CO

ChemicalStructure/PW C000057
type: ChemicalStructure
structure format: SMILES

Adenosine triphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Adenosine triphosphate

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Reference/UniProt P42838
type: UnificationXref
id: P42838
db: UniProt

ReactionCatalysis7155
type: Catalysis
controller: Lysophospholipase NTE1
controlled: 3.1.1.5
control type: ACTIVATION

Reference/KEGG Compound C00165
type: UnificationXref
id: C00165
db: KEGG Compound

Compound/PW C006392 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: LysoPC(16:1(9Z)/0:0)
stoichiometric coefficient: 1.0

Water
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Water

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000065
type: ChemicalStructure
structure format: SMILES
structure data: C[N+](C)(C)CCO

Reference/PubChem-compound 86583448
type: UnificationXref
id: 86583448
db: PubChem-compound

ChemicalStructure/PW C000064
type: ChemicalStructure
structure format: SMILES

Compound/PW C000170/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

ReactionCatalysis7159
type: Catalysis
controller: Ale1p acyltransferase
controlled: Reaction7542
control type: ACTIVATION

ReactionCatalysis7158
type: Catalysis
controller: diacylglycerol cholinephosphotransferase
controlled: Reaction7546
control type: ACTIVATION

Lyso-PS(14:0/0:0)
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Lyso-PS(14:0/0:0)

Reference/ChemSpider 5901
type: UnificationXref
id: 5901
db: ChemSpider

Reference/ChemSpider 7825759
type: UnificationXref
id: 7825759
db: ChemSpider

Reference/PubChem-compound 305
type: UnificationXref
id: 305
db: PubChem-compound

Reference/ChEBI CHEBI 18132
type: UnificationXref
id: CHEBI:18132
db: ChEBI

Reference/KEGG Compound C00055
type: UnificationXref
id: C00055
db: KEGG Compound

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Compound/PW C005005 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: PE(16:1(9Z)/16:1(9Z))
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00063
type: UnificationXref
id: C00063
db: KEGG Compound

a carboxylate
type: SmallMoleculeReference

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/KEGG Compound C04308
type: UnificationXref
id: C04308
db: KEGG Compound

Reference/PubChem-compound 24779461
type: UnificationXref
id: 24779461
db: PubChem-compound

PS(14:0/14:0)
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: PS(14:0/14:0)

Reference/CAS 107-73-3
type: UnificationXref
id: 107-73-3
db: CAS

Reference/CAS 65-47-4
type: UnificationXref
id: 65-47-4
db: CAS

Reference/UniProt P17898
type: UnificationXref
id: P17898
db: UniProt

Lyso-PI(14:0/0:0)
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Lyso-PI(14:0/0:0)

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Compound/PW C007097 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: LysoPE(14:0/0:0)
stoichiometric coefficient: 1.0

Reference/ChemSpider 31983
type: UnificationXref
id: 31983
db: ChemSpider

LysoPC(16:1(9Z)/0:0)
type: SmallMolecule
cellular location: Cell Membrane
entity reference: LysoPC(16:1(9Z)/0:0)

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Reference/BioCyc CMP
type: UnificationXref
id: CMP
db: BioCyc

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Phosphorylcholine
type: SmallMoleculeReference
xref: Reference/CAS 107-73-3
xref: Reference/HMDB HMDB0001565
xref: Reference/BioCyc PHOSPHORYL-CHOLINE
xref: Reference/PubChem-compound 1014
xref: Reference/ChEBI CHEBI 18132
xref: Reference/KEGG Compound C00588
xref: Reference/ChemSpider 989
chemical formula: C5H15NO4P
molecular weight: 184.07387
structure: ChemicalStructure/PW C001202

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/PubChem-compound 6176
type: UnificationXref
id: 6176
db: PubChem-compound

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

PE-NMe2(16:1(9Z)/16:1(9Z))
type: SmallMoleculeReference
xref: Reference/KEGG Compound C04308
xref: Reference/HMDB HMDB0113849
xref: Reference/BioCyc CPD-160
xref: Reference/ChEBI CHEBI 52332
chemical formula: C39H74NO8P
molecular weight: 715.5152
structure: ChemicalStructure/PW C057650

Reference/BioCyc GLYCEROL-3P
type: UnificationXref
id: GLYCEROL-3P
db: BioCyc

Reference/KEGG Compound C00093
type: UnificationXref
id: C00093
db: KEGG Compound

Reaction7542
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006392/Stoichiometry/1.0
participant stoichiometry: Compound/PW C004051/Stoichiometry/1.0
right: PC(16:1(9Z)/16:1(9Z))
spontaneous: false
left: LysoPC(16:1(9Z)/0:0)
name: LysoPC(16:1(9Z)/0:0) → PC(16:1(9Z)/16:1(9Z))
conversion direction: LEFT_TO_RIGHT

3.1.1.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006392/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000059/Stoichiometry/1.0
participant stoichiometry: Compound/Generic271/Stoichiometry/1.0
right: a carboxylate
right: Glycerophosphocholine
spontaneous: false
EC number: 3.1.1.5
left: Water
left: LysoPC(16:1(9Z)/0:0)
name: LysoPC(16:1(9Z)/0:0) + Water → Glycerophosphocholine + a carboxylate
conversion direction: LEFT_TO_RIGHT

2.1.1.17,2.1.1.71
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000749/Stoichiometry/1.0
participant stoichiometry: Compound/PW C057492/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921/Stoichiometry/1.0
participant stoichiometry: Compound/PW C057650/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: S-Adenosylhomocysteine
right: Hydrogen Ion
right: PE-NMe2(16:1(9Z)/16:1(9Z))
spontaneous: false
EC number: 2.1.1.17,2.1.1.71
left: PE-NMe(16:1(9Z)/16:1(9Z))
left: S-Adenosylmethionine
name: PE-NMe(16:1(9Z)/16:1(9Z)) + S-Adenosylmethionine → Hydrogen Ion + PE-NMe2(16:1(9Z)/16:1(9Z)) + S-Adenosylhomocysteine
conversion direction: LEFT_TO_RIGHT

2.1.1.17
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000749/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921/Stoichiometry/1.0
participant stoichiometry: Compound/PW C057492/Stoichiometry/1.0
participant stoichiometry: Compound/PW C005005/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: S-Adenosylhomocysteine
right: Hydrogen Ion
right: PE-NMe(16:1(9Z)/16:1(9Z))
spontaneous: false
EC number: 2.1.1.17
left: PE(16:1(9Z)/16:1(9Z))
left: S-Adenosylmethionine
name: PE(16:1(9Z)/16:1(9Z)) + S-Adenosylmethionine → Hydrogen Ion + PE-NMe(16:1(9Z)/16:1(9Z)) + S-Adenosylhomocysteine
conversion direction: LEFT_TO_RIGHT

Reaction7546
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000064/Stoichiometry/1.0
participant stoichiometry: Compound/PW C003179/Stoichiometry/1.0
participant stoichiometry: Compound/PW C004051/Stoichiometry/1.0
participant stoichiometry: Compound/PW C043034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Cytidine monophosphate
right: Hydrogen Ion
right: PC(16:1(9Z)/16:1(9Z))
spontaneous: false
left: DG(16:1(9Z)/16:1(9Z)/0:0)
left: CDP-Choline
name: CDP-Choline + DG(16:1(9Z)/16:1(9Z)/0:0) → Cytidine monophosphate + Hydrogen Ion + PC(16:1(9Z)/16:1(9Z))
conversion direction: LEFT_TO_RIGHT

Reaction7545
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000749/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921/Stoichiometry/1.0
participant stoichiometry: Compound/PW C004051/Stoichiometry/1.0
participant stoichiometry: Compound/PW C057650/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: S-Adenosylhomocysteine
right: Hydrogen Ion
right: PC(16:1(9Z)/16:1(9Z))
spontaneous: false
left: PE-NMe2(16:1(9Z)/16:1(9Z))
left: S-Adenosylmethionine
name: PE-NMe2(16:1(9Z)/16:1(9Z)) + S-Adenosylmethionine → Hydrogen Ion + PC(16:1(9Z)/16:1(9Z)) + S-Adenosylhomocysteine
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Reference/TAXONOMY 4932
type: UnificationXref
id: 4932
db: TAXONOMY

Reference/ChemSpider 5941
type: UnificationXref
id: 5941
db: ChemSpider

PE-NMe2(16:1(9Z)/16:1(9Z))
type: SmallMolecule
entity reference: PE-NMe2(16:1(9Z)/16:1(9Z))

Phosphorylcholine
type: SmallMolecule
entity reference: Phosphorylcholine

Reference/PubChem-compound 25246222
type: UnificationXref
id: 25246222
db: PubChem-compound

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

diacylglycerol cholinephosphotransferase
type: ProteinReference
xref: Reference/UniProt P17898

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Compound/PW C000081/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glycerol 3-phosphate
stoichiometric coefficient: 1.0

LysoPE(14:0/0:0)
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: LysoPE(14:0/0:0)

Reference/UniProt P13259
type: UnificationXref
id: P13259
db: UniProt

Reference/CAS 62-49-7
type: UnificationXref
id: 62-49-7
db: CAS

Reference/ChemSpider 989
type: UnificationXref
id: 989
db: ChemSpider

Reference/HMDB HMDB0112948
type: UnificationXref
id: HMDB0112948
db: HMDB

Reference/BioCyc CPD-160
type: UnificationXref
id: CPD-160
db: BioCyc

Ale1p acyltransferase
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Ale1p acyltransferase

Reference/KEGG Compound C04230
type: UnificationXref
id: C04230
db: KEGG Compound

Lysophospholipase NTE1
type: ProteinReference
xref: Reference/UniProt Q04958

Reference/HMDB HMDB0000082
type: UnificationXref
id: HMDB0000082
db: HMDB

LysoPE(14:0/0:0)
type: SmallMoleculeReference
xref: Reference/PubChem-compound 86583448
xref: Reference/ChemSpider 7826020
xref: Reference/HMDB HMDB0011500
xref: Reference/ChEBI CHEBI 84299
chemical formula: C19H40NO7P
molecular weight: 425.25424
structure: ChemicalStructure/PW C007097

Choline kinase
type: ProteinReference
xref: Reference/UniProt P20485

CDP-Choline
type: SmallMolecule
entity reference: CDP-Choline

Choline-phosphate cytidylyltransferase
type: ProteinReference
xref: Reference/UniProt P13259

Reference/HMDB HMDB0000086
type: UnificationXref
id: HMDB0000086
db: HMDB

ChemicalStructure/PW C000081
type: ChemicalStructure
structure format: SMILES
structure data: OC[C@@H](O)COP(O)(O)=O

CDP-Choline
type: SmallMoleculeReference
xref: Reference/BioCyc CDP-CHOLINE
xref: Reference/ChemSpider 13207
xref: Reference/HMDB HMDB0001413
xref: Reference/ChEBI CHEBI 16436
xref: Reference/KEGG Compound C00307
xref: Reference/PubChem-compound 11583971
xref: Reference/CAS 987-78-0
chemical formula: C14H26N4O11P2
molecular weight: 488.10733
structure: ChemicalStructure/PW C043034

LysoPE(14:0/0:0)
type: SmallMolecule
cellular location: Cell Membrane
entity reference: LysoPE(14:0/0:0)

Reference/PubChem-compound 1014
type: UnificationXref
id: 1014
db: PubChem-compound

Glycerophosphocholine
type: SmallMolecule
entity reference: Glycerophosphocholine

Cytidine triphosphate
type: SmallMolecule
entity reference: Cytidine triphosphate

Reference/BioCyc L-1-PHOSPHATIDYL-ETHANOLAMINE
type: UnificationXref
id: L-1-PHOSPHATIDYL-ETHANOLAMINE
db: BioCyc

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Lyso-PS(0:0/14:0)
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Lyso-PS(0:0/14:0)

Reference/ChEBI CHEBI 15958
type: UnificationXref
id: CHEBI:15958
db: ChEBI

Pyrophosphate
type: SmallMolecule
entity reference: Pyrophosphate

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/KEGG Compound C01241
type: UnificationXref
id: C01241
db: KEGG Compound

Compound/PW C000414/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Compound/PW C045278 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lyso-PI(0:0/14:0)
stoichiometric coefficient: 1.0

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

ChemicalStructure/PW C007097
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Lyso-PI(0:0/14:0)
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Lyso-PI(0:0/14:0)

Reference/CAS 76790-27-7
type: UnificationXref
id: 76790-27-7
db: CAS

Reference/BioCyc CPD-405
type: UnificationXref
id: CPD-405
db: BioCyc

ChemicalStructure/PW C057492
type: ChemicalStructure
structure format: SMILES

Phosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Phosphate

Reference/BioCyc ADENOSYL-HOMO-CYS
type: UnificationXref
id: ADENOSYL-HOMO-CYS
db: BioCyc

Compound/PW C000059/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glycerophosphocholine
stoichiometric coefficient: 1.0

Reference/CAS 485-80-3
type: UnificationXref
id: 485-80-3
db: CAS

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Reference/PubChem-compound 71920
type: UnificationXref
id: 71920
db: PubChem-compound

Compound/PW C045274 Endoplasmic Reticulum/Stoichiometry/2.0
type: Stoichiometry
physical entity: Lyso-PS(14:0/0:0)
stoichiometric coefficient: 2.0

Reference/ChEBI CHEBI 73851
type: UnificationXref
id: CHEBI:73851
db: ChEBI

PI(14:0/14:0)
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: PI(14:0/14:0)

Reference/HMDB HMDB0001413
type: UnificationXref
id: HMDB0001413
db: HMDB

2.7.7.15
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001202/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000057/Stoichiometry/1.0
participant stoichiometry: Compound/PW C043034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: CDP-Choline
right: Pyrophosphate
spontaneous: false
EC number: 2.7.7.15
left: Cytidine triphosphate
left: Hydrogen Ion
left: Phosphorylcholine
name: Cytidine triphosphate + Hydrogen Ion + Phosphorylcholine → CDP-Choline + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C045278
type: ChemicalStructure
structure format: SMILES

2.7.1.32
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001202/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000065/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Adenosine diphosphate
right: Hydrogen Ion
right: Phosphorylcholine
spontaneous: false
EC number: 2.7.1.32
left: Choline
left: Adenosine triphosphate
name: Adenosine triphosphate + Choline → Adenosine diphosphate + Hydrogen Ion + Phosphorylcholine
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C045277
type: ChemicalStructure
structure format: SMILES
structure data: CCCCCCCCCCCCCC(=O)OC(CO)COP([O-])(=O)OCC([NH3+])C([O-])=O

Compound/PW C057650/Stoichiometry/1.0
type: Stoichiometry
physical entity: PE-NMe2(16:1(9Z)/16:1(9Z))
stoichiometric coefficient: 1.0

ChemicalStructure/PW C045274
type: ChemicalStructure
structure format: SMILES
structure data: CCCCCCCCCCCCCC(=O)OCC(O)COP([O-])(=O)OCC([NH3+])C([O-])=O

ChemicalStructure/PW C045276
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C045275
type: ChemicalStructure
structure format: SMILES

Phosphatidyl-N-methylethanolamine N-methyltransferase
type: ProteinReference
xref: Reference/UniProt P05375

Phosphatidylethanolamine N-methyltransferase
type: ProteinReference
xref: Reference/UniProt P05374

Compound/PW C045274 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lyso-PS(14:0/0:0)
stoichiometric coefficient: 1.0

Reference/ChemSpider 24766671
type: UnificationXref
id: 24766671
db: ChemSpider

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Compound/PW C000057/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cytidine triphosphate
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Reference/HMDB HMDB0010383
type: UnificationXref
id: HMDB0010383
db: HMDB

Reference/ChEBI CHEBI 15414
type: UnificationXref
id: CHEBI:15414
db: ChEBI

PE-NMe(16:1(9Z)/16:1(9Z))
type: SmallMoleculeReference
xref: Reference/KEGG Compound C01241
xref: Reference/BioCyc CPD-405
xref: Reference/ChEBI CHEBI 15958
xref: Reference/HMDB HMDB0112948
chemical formula: C38H72NO8P
molecular weight: 701.4996
structure: ChemicalStructure/PW C057492

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Glycerophosphodiester phosphodiesterase GDE1
type: Protein
entity reference: Glycerophosphodiester phosphodiesterase GDE1

Glycerol 3-phosphate
type: SmallMoleculeReference
xref: Reference/BioCyc GLYCEROL-3P
xref: Reference/HMDB HMDB0000126
xref: Reference/ChemSpider 388308
xref: Reference/CAS 17989-41-2
xref: Reference/KEGG Compound C00093
xref: Reference/ChEBI CHEBI 15978
xref: Reference/PubChem-compound 439162
chemical formula: C3H9O6P
molecular weight: 172.01367
structure: ChemicalStructure/PW C000081

Reference/ChEBI CHEBI 83717
type: UnificationXref
id: CHEBI:83717
db: ChEBI

Lyso-PS(14:0/0:0)
type: SmallMoleculeReference
chemical formula: C20H39NO9P
molecular weight: 468.2368
structure: ChemicalStructure/PW C045274

ChemicalStructure/PW C043034
type: ChemicalStructure
structure format: SMILES

Lyso-PI(14:0/0:0)
type: SmallMoleculeReference
chemical formula: C23H45O12P
molecular weight: 544.2649
structure: ChemicalStructure/PW C045275

Lyso-PI(0:0/14:0)
type: SmallMoleculeReference
chemical formula: C23H45O12P
molecular weight: 544.2649
structure: ChemicalStructure/PW C045278

Glycerol 3-phosphate
type: SmallMolecule
entity reference: Glycerol 3-phosphate

PI(14:0/14:0)
type: SmallMoleculeReference
chemical formula: C37H71O13P
molecular weight: 754.46326
structure: ChemicalStructure/PW C045276

Lyso-PS(0:0/14:0)
type: SmallMoleculeReference
chemical formula: C20H39NO9P
molecular weight: 468.2368
structure: ChemicalStructure/PW C045277

Choline-phosphate cytidylyltransferase
type: Protein
entity reference: Choline-phosphate cytidylyltransferase

Ale1p acyltransferase
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Ale1p acyltransferase

Choline kinase
type: Protein
entity reference: Choline kinase

Reference/BioCyc S-ADENOSYLMETHIONINE
type: UnificationXref
id: S-ADENOSYLMETHIONINE
db: BioCyc

PE-NMe(16:1(9Z)/16:1(9Z))
type: SmallMolecule
entity reference: PE-NMe(16:1(9Z)/16:1(9Z))

Reference/HMDB HMDB0012330
type: UnificationXref
id: HMDB0012330
db: HMDB

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

Reference/HMDB HMDB0001565
type: UnificationXref
id: HMDB0001565
db: HMDB

Compound/PW C001202/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphorylcholine
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001202
type: ChemicalStructure
structure format: SMILES
structure data: C[N+](C)(C)CCOP(O)(O)=O

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/GENE ONTOLOGY GO 0005743
type: UnificationXref
id: GO:0005743
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 15978
type: UnificationXref
id: CHEBI:15978
db: ChEBI

Cytidine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17677
xref: Reference/CAS 65-47-4
xref: Reference/PubChem-compound 6176
xref: Reference/KEGG Compound C00063
xref: Reference/ChemSpider 5941
xref: Reference/HMDB HMDB0000082
xref: Reference/BioCyc CTP
chemical formula: C9H16N3O14P3
molecular weight: 482.9845
structure: ChemicalStructure/PW C000057

Lysophospholipase NTE1
type: Protein
entity reference: Lysophospholipase NTE1

Compound/PW C045275 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lyso-PI(14:0/0:0)
stoichiometric coefficient: 1.0

Compound/PW C045276 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: PI(14:0/14:0)
stoichiometric coefficient: 1.0

Reference/BioCyc GLYCERYLPHOSPHORYLCHOLINE
type: UnificationXref
id: GLYCERYLPHOSPHORYLCHOLINE
db: BioCyc

diacylglycerol cholinephosphotransferase
type: Protein
entity reference: diacylglycerol cholinephosphotransferase

Reference/BioCyc CPD-563
type: UnificationXref
id: CPD-563
db: BioCyc

Glycerophosphocholine
type: SmallMoleculeReference
xref: Reference/BioCyc GLYCERYLPHOSPHORYLCHOLINE
xref: Reference/ChemSpider 64931
xref: Reference/PubChem-compound 71920
xref: Reference/KEGG Compound C00670
xref: Reference/HMDB HMDB0000086
xref: Reference/CAS 28319-77-9
xref: Reference/ChEBI CHEBI 16870
chemical formula: C8H20NO6P
molecular weight: 257.1028
structure: ChemicalStructure/PW C000059

Reference/PubChem-compound 9546809
type: UnificationXref
id: 9546809
db: PubChem-compound

Cytidine monophosphate
type: SmallMolecule
entity reference: Cytidine monophosphate

Adenosine diphosphate
type: SmallMolecule
entity reference: Adenosine diphosphate

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/HMDB HMDB0000126
type: UnificationXref
id: HMDB0000126
db: HMDB

Choline
type: SmallMolecule
entity reference: Choline

Choline
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15354
xref: Reference/ChemSpider 299
xref: Reference/BioCyc CPD-563
xref: Reference/PubChem-compound 305
xref: Reference/CAS 62-49-7
xref: Reference/HMDB HMDB0000097
xref: Reference/KEGG Compound C00114
chemical formula: C5H14NO
molecular weight: 104.10754
structure: ChemicalStructure/PW C000065

Cytidine monophosphate
type: SmallMoleculeReference
xref: Reference/BioCyc CMP
xref: Reference/ChemSpider 5901
xref: Reference/PubChem-compound 6131
xref: Reference/ChEBI CHEBI 17361
xref: Reference/KEGG Compound C00055
xref: Reference/HMDB HMDB0000095
xref: Reference/CAS 63-37-6
chemical formula: C9H14N3O8P
molecular weight: 323.05185
structure: ChemicalStructure/PW C000064

Endoplasmic Reticulum
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005783

Endoplasmic Reticulum Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005789

Reference/UniProt Q04958
type: UnificationXref
id: Q04958
db: UniProt

Ale1p acyltransferase
type: Protein
entity reference: Ale1p acyltransferase

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

ReactionCatalysis6979
type: Catalysis
controller: Choline-phosphate cytidylyltransferase
controlled: 2.7.7.15
control type: ACTIVATION

ReactionCatalysis6978
type: Catalysis
controller: Choline kinase
controlled: 2.7.1.32
control type: ACTIVATION

ReactionCatalysis6977
type: Catalysis
controller: Glycerophosphodiester phosphodiesterase GDE1
controlled: 3.1.4.46
control type: ACTIVATION

Reference/UniProt P20485
type: UnificationXref
id: P20485
db: UniProt

ChemicalStructure/PW C006392
type: ChemicalStructure
structure format: SMILES
structure data: CCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)COP([O-])(=O)OCC[N+](C)(C)C

PS(14:0/14:0)
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 18303
xref: Reference/BioCyc L-1-PHOSPHATIDYL-SERINE
xref: Reference/KEGG Compound C02737
xref: Reference/PubChem-compound 123699
xref: Reference/HMDB HMDB0012330
xref: Reference/ChemSpider 110272
chemical formula: C34H66NO10P
molecular weight: 679.44244
structure: ChemicalStructure/PW C007860

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/ChemSpider 24766525
type: UnificationXref
id: 24766525
db: ChemSpider

Compound/PW C045277 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lyso-PS(0:0/14:0)
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000939
type: UnificationXref
id: HMDB0000939
db: HMDB

a carboxylate
type: SmallMolecule
entity reference: a carboxylate

Reference/PubChem-compound 9543679
type: UnificationXref
id: 9543679
db: PubChem-compound

Compound/PW C007097 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: LysoPE(14:0/0:0)
stoichiometric coefficient: 1.0

Compound/PW C006392/Stoichiometry/1.0
type: Stoichiometry
physical entity: LysoPC(16:1(9Z)/0:0)
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/ChEBI CHEBI 16870
type: UnificationXref
id: CHEBI:16870
db: ChEBI

Lysolipid Incorporation into ER PC(16:1(9Z)/16:1(9Z))
type: Pathway
pathway order: PathwayEnzymeReaction/2181332
pathway order: PathwayEnzymeReaction/2181343
pathway order: PathwayEnzymeReaction/2181333
pathway order: PathwayEnzymeReaction/2181344
pathway order: PathwayEnzymeReaction/2181334
pathway order: PathwayEnzymeReaction/2181345
pathway order: PathwayEnzymeReaction/2181335
pathway order: PathwayEnzymeReaction/2181346
pathway order: PathwayEnzymeReaction/2181340
pathway order: PathwayEnzymeReaction/2181330
pathway order: PathwayEnzymeReaction/2181341
pathway order: PathwayEnzymeReaction/2181331
pathway order: PathwayEnzymeReaction/2181342
pathway order: PathwayEnzymeReaction/2181329
pathway order: PathwayEnzymeReaction/2181336
pathway order: PathwayEnzymeReaction/2181337
pathway order: PathwayEnzymeReaction/2181327
pathway order: PathwayEnzymeReaction/2181338
pathway order: PathwayEnzymeReaction/2181328
pathway order: PathwayEnzymeReaction/2181339
pathway component: ReactionCatalysis7386
pathway component: ReactionCatalysis7385
pathway component: ReactionCatalysis7384
pathway component: ReactionCoupledTransportCatalysis254
pathway component: ReactionCoupledTransportCatalysis252
pathway component: ReactionCoupledTransportCatalysis251
pathway component: ReactionCoupledTransportCatalysis250
pathway component: ReactionCatalysis6979
pathway component: ReactionCatalysis6978
pathway component: ReactionCatalysis6977
pathway component: ReactionCoupledTransport215
pathway component: ReactionCoupledTransport213
pathway component: ReactionCoupledTransport214
pathway component: ReactionCoupledTransport211
pathway component: ReactionCoupledTransport212
pathway component: ReactionCoupledTransport210
pathway component: ReactionCoupledTransportCatalysis249
pathway component: ReactionCoupledTransportCatalysis248
pathway component: ReactionCatalysis7155
pathway component: ReactionCoupledTransportCatalysis247
pathway component: ReactionCoupledTransportCatalysis246
pathway component: ReactionCoupledTransportCatalysis245
pathway component: ReactionCoupledTransportCatalysis244
pathway component: ReactionCoupledTransportCatalysis243
pathway component: ReactionCoupledTransport208
pathway component: ReactionCoupledTransport209
pathway component: 3.1.4.46
pathway component: ReactionCoupledTransport207
pathway component: 2.7.7.15
pathway component: ReactionCatalysis7159
pathway component: ReactionCoupledTransport244
pathway component: 2.7.1.32
pathway component: ReactionCatalysis7158
pathway component: ReactionCoupledTransport465
pathway component: Reaction7542
pathway component: 3.1.1.5
pathway component: 2.1.1.17,2.1.1.71
pathway component: 2.1.1.17
pathway component: Reaction7546
pathway component: Reaction7545
xref: Reference/SMPDB SMP0002515
xref: Reference/PathWhiz PW002785
organism: Saccharomyces cerevisiae

Reference/GENE ONTOLOGY GO 0005789
type: UnificationXref
id: GO:0005789
db: GENE ONTOLOGY

Compound/PW C004051/Stoichiometry/1.0
type: Stoichiometry
physical entity: PC(16:1(9Z)/16:1(9Z))
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005783
type: UnificationXref
id: GO:0005783
db: GENE ONTOLOGY

ReactionCoupledTransportCatalysis249
type: Catalysis
controller: Phospholipid-transporting ATPase
controlled: ReactionCoupledTransport212
control type: ACTIVATION

ReactionCoupledTransportCatalysis248
type: Catalysis
controller: Ale1p acyltransferase
controlled: ReactionCoupledTransport211
control type: ACTIVATION

ReactionCoupledTransportCatalysis247
type: Catalysis
controller: Phospholipid-transporting ATPase
controlled: ReactionCoupledTransport210
control type: ACTIVATION

ReactionCoupledTransportCatalysis246
type: Catalysis
controller: Ale1p acyltransferase
controlled: ReactionCoupledTransport209
control type: ACTIVATION

ReactionCoupledTransportCatalysis245
type: Catalysis
controller: Phospholipid-transporting ATPase
controlled: ReactionCoupledTransport208
control type: ACTIVATION

ReactionCoupledTransportCatalysis244
type: Catalysis
controller: Phospholipid-transporting ATPase
controlled: ReactionCoupledTransport207
control type: ACTIVATION

ReactionCoupledTransportCatalysis243
type: Catalysis
controller: Phospholipid-transporting ATPase
controlled: ReactionCoupledTransport244
control type: ACTIVATION

Compound/Generic271/Stoichiometry/1.0
type: Stoichiometry
physical entity: a carboxylate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

ChemicalStructure/PW C057650
type: ChemicalStructure
structure format: SMILES

Reference/CAS 987-78-0
type: UnificationXref
id: 987-78-0
db: CAS

Alkylphosphocholine resistance protein LEM3
type: Protein
cellular location: Cell Membrane
entity reference: Alkylphosphocholine resistance protein LEM3

Reference/ChEBI CHEBI 16337
type: UnificationXref
id: CHEBI:16337
db: ChEBI

Lyso-PI(14:0/0:0)
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Lyso-PI(14:0/0:0)

Reference/HMDB HMDB0011500
type: UnificationXref
id: HMDB0011500
db: HMDB

Reference/ChEBI CHEBI 84417
type: UnificationXref
id: CHEBI:84417
db: ChEBI

Reference/ChemSpider 299
type: UnificationXref
id: 299
db: ChemSpider

Reference/ChemSpider 7826020
type: UnificationXref
id: 7826020
db: ChemSpider

PE(16:1(9Z)/16:1(9Z))
type: SmallMoleculeReference
xref: Reference/PubChem-compound 9546809
xref: Reference/BioCyc L-1-PHOSPHATIDYL-ETHANOLAMINE
xref: Reference/ChEBI CHEBI 16337
xref: Reference/ChemSpider 7825759
xref: Reference/HMDB HMDB0008957
xref: Reference/KEGG Compound C00350
chemical formula: C37H70NO8P
molecular weight: 687.4839
structure: ChemicalStructure/PW C005005

PC(16:1(9Z)/16:1(9Z))
type: SmallMolecule
entity reference: PC(16:1(9Z)/16:1(9Z))

Reference/HMDB HMDB0007128
type: UnificationXref
id: HMDB0007128
db: HMDB

Reference/UniProt P32660
type: UnificationXref
id: P32660
db: UniProt

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 17677
type: UnificationXref
id: CHEBI:17677
db: ChEBI

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Phospholipid-transporting ATPase DNF2
type: ProteinReference
xref: Reference/UniProt Q12675
organism: Saccharomyces cerevisiae

Phospholipid-transporting ATPase DNF1
type: ProteinReference
xref: Reference/UniProt P32660
organism: Saccharomyces cerevisiae

Ale1p acyltransferase
type: ProteinReference

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Alkylphosphocholine resistance protein LEM3
type: ProteinReference
xref: Reference/UniProt P42838
organism: Saccharomyces cerevisiae

Reference/SMPDB SMP0002515
type: UnificationXref
id: SMP0002515
db: SMPDB

Reference/BioCyc L-1-PHOSPHATIDYL-SERINE
type: UnificationXref
id: L-1-PHOSPHATIDYL-SERINE
db: BioCyc

Reference/CAS 17989-41-2
type: UnificationXref
id: 17989-41-2
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

S-Adenosylmethionine
type: SmallMolecule
entity reference: S-Adenosylmethionine

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Compound/PW C007860 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: PS(14:0/14:0)
stoichiometric coefficient: 1.0

Reference/PubChem-compound 11583971
type: UnificationXref
id: 11583971
db: PubChem-compound

Reference/ChEBI CHEBI 16436
type: UnificationXref
id: CHEBI:16436
db: ChEBI

Lyso-PI(0:0/14:0)
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Lyso-PI(0:0/14:0)

Reference/PathWhiz PW002785
type: UnificationXref
id: PW002785
db: PathWhiz

ChemicalStructure/PW C000749
type: ChemicalStructure
structure format: SMILES

PE(16:1(9Z)/16:1(9Z))
type: SmallMolecule
entity reference: PE(16:1(9Z)/16:1(9Z))

Compound/PW C000749/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylhomocysteine
stoichiometric coefficient: 1.0

Lyso-PS(0:0/14:0)
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Lyso-PS(0:0/14:0)

Reference/ChEBI CHEBI 15354
type: UnificationXref
id: CHEBI:15354
db: ChEBI

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/KEGG Compound C00307
type: UnificationXref
id: C00307
db: KEGG Compound

Reference/ChEBI CHEBI 16680
type: UnificationXref
id: CHEBI:16680
db: ChEBI

Reference/PubChem-compound 24762165
type: UnificationXref
id: 24762165
db: PubChem-compound

DG(16:1(9Z)/16:1(9Z)/0:0)
type: SmallMolecule
entity reference: DG(16:1(9Z)/16:1(9Z)/0:0)

Adenosine diphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Adenosine diphosphate

DG(16:1(9Z)/16:1(9Z)/0:0)
type: SmallMoleculeReference
xref: Reference/ChemSpider 7822629
xref: Reference/BioCyc DIACYLGLYCEROL
xref: Reference/ChEBI CHEBI 84417
xref: Reference/PubChem-compound 9543679
xref: Reference/KEGG Compound C00165
xref: Reference/HMDB HMDB0007128
chemical formula: C35H64O5
molecular weight: 564.4754
structure: ChemicalStructure/PW C003179

Reference/HMDB HMDB0008002
type: UnificationXref
id: HMDB0008002
db: HMDB