Reference/CAS 1032-65-1
type: UnificationXref
id: 1032-65-1
db: CAS

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/TAXONOMY 3702
type: UnificationXref
id: 3702
db: TAXONOMY

Reference/CAS 365-07-1
type: UnificationXref
id: 365-07-1
db: CAS

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/CAS 964-26-1
type: UnificationXref
id: 964-26-1
db: CAS

Reference/SMPDB SMP0012077
type: UnificationXref
id: SMP0012077
db: SMPDB

Compound/PW C000008 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Deoxycytidine
stoichiometric coefficient: 1.0

Compound/PW C000950 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Thymidylic acid
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Compound/PW C000187 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thymidine
stoichiometric coefficient: 1.0

nucleoside diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: nucleoside diphosphate

Compound/PW C001087 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: dUMP
stoichiometric coefficient: 1.0

5-Thymidylic acid
type: SmallMoleculeReference
xref: Reference/BioCyc TMP
xref: Reference/PubChem-compound 9700
xref: Reference/HMDB HMDB0001227
xref: Reference/ChemSpider 9319
xref: Reference/CAS 365-07-1
xref: Reference/KEGG Compound C00364
xref: Reference/ChEBI CHEBI 17013
chemical formula: C10H15N2O8P
molecular weight: 322.0566
structure: ChemicalStructure/PW C000950

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/KEGG Compound C00201
type: UnificationXref
id: C00201
db: KEGG Compound

Ammonium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0041827
xref: Reference/CAS 14798-03-9
xref: Reference/PubChem-compound 16741146
xref: Reference/KEGG Compound C01342
xref: Reference/ChEBI CHEBI 28938
xref: Reference/ChemSpider 218
chemical formula: H4N
molecular weight: 18.034374
structure: ChemicalStructure/PW C022608

TransportCatalysis804
type: Catalysis
controller: nucleoside carrier protein
controlled: Transport904
control type: ACTIVATION

TransportCatalysis803
type: Catalysis
controller: nucleoside carrier protein
controlled: Transport903
control type: ACTIVATION

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Reference/KEGG Compound C00459
type: UnificationXref
id: C00459
db: KEGG Compound

Reference/KEGG Compound C00458
type: UnificationXref
id: C00458
db: KEGG Compound

Deoxycytidine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15698
xref: Reference/HMDB HMDB0000014
xref: Reference/CAS 951-77-9
xref: Reference/KEGG Compound C00881
xref: Reference/PubChem-compound 13711
xref: Reference/ChemSpider 13117
xref: Reference/BioCyc DEOXYCYTIDINE
chemical formula: C9H13N3O4
molecular weight: 227.0906
structure: ChemicalStructure/PW C000008

Deoxyuridine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00526
xref: Reference/HMDB HMDB0000012
xref: Reference/BioCyc DEOXYURIDINE
xref: Reference/PubChem-compound 13712
xref: Reference/ChemSpider 13118
xref: Reference/ChEBI CHEBI 16450
xref: Reference/CAS 951-78-0
chemical formula: C9H12N2O5
molecular weight: 228.07462
structure: ChemicalStructure/PW C000007

Reference/CAS 365-08-2
type: UnificationXref
id: 365-08-2
db: CAS

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/KEGG Compound C00214
type: UnificationXref
id: C00214
db: KEGG Compound

Reference/KEGG Compound C00454
type: UnificationXref
id: C00454
db: KEGG Compound

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

ChemicalStructure/PW C000790
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C001087
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc DUMP
type: UnificationXref
id: DUMP
db: BioCyc

Reference/PubChem-compound 64968
type: UnificationXref
id: 64968
db: PubChem-compound

Reference/CAS 800-73-7
type: UnificationXref
id: 800-73-7
db: CAS

5,10-methylene-tetrahydrofolate
type: SmallMoleculeReference

Reference/PubChem-compound 164628
type: UnificationXref
id: 164628
db: PubChem-compound

Reference/HMDB HMDB0001409
type: UnificationXref
id: HMDB0001409
db: HMDB

Reference/ChemSpider 58493
type: UnificationXref
id: 58493
db: ChemSpider

Reference/UniProt Q05762
type: UnificationXref
id: Q05762
db: UniProt

dCMP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00239
xref: Reference/HMDB HMDB0001202
xref: Reference/CAS 1032-65-1
xref: Reference/BioCyc DCMP
xref: Reference/PubChem-compound 13945
xref: Reference/ChemSpider 13343
xref: Reference/ChEBI CHEBI 15918
chemical formula: C9H14N3O7P
molecular weight: 307.05695
structure: ChemicalStructure/PW C000937

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Thymidine 5'-triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Thymidine 5'-triphosphate

Protein/11643 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: cytidine deaminase
stoichiometric coefficient: 2.0

Reference/UniProt Q9S750
type: UnificationXref
id: Q9S750
db: UniProt

Reference/CAS 2056-98-6
type: UnificationXref
id: 2056-98-6
db: CAS

Reference/BioCyc THYMIDINE
type: UnificationXref
id: THYMIDINE
db: BioCyc

Reference/KEGG Compound C00239
type: UnificationXref
id: C00239
db: KEGG Compound

Reference/ChemSpider 144320
type: UnificationXref
id: 144320
db: ChemSpider

Reference/UniProt Q0WW55
type: UnificationXref
id: Q0WW55
db: UniProt

dTDP
type: SmallMoleculeReference
xref: Reference/CAS 491-97-4
xref: Reference/ChemSpider 144320
xref: Reference/PubChem-compound 164628
xref: Reference/KEGG Compound C00363
xref: Reference/ChEBI CHEBI 18075
xref: Reference/HMDB HMDB0001274
xref: Reference/BioCyc TDP
chemical formula: C10H16N2O11P2
molecular weight: 402.02292
structure: ChemicalStructure/PW C000987

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000008
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000007
type: ChemicalStructure
structure format: SMILES

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/ChemSpider 218
type: UnificationXref
id: 218
db: ChemSpider

Reference/ChEBI CHEBI 28846
type: UnificationXref
id: CHEBI:28846
db: ChEBI

dTDP
type: SmallMolecule
cellular location: Cytosol
entity reference: dTDP

Reference/ChemSpider 13118
type: UnificationXref
id: 13118
db: ChemSpider

Reference/ChemSpider 13117
type: UnificationXref
id: 13117
db: ChemSpider

dUMP
type: SmallMolecule
cellular location: Cytosol
entity reference: dUMP

Compound/PW C000962 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: dCDP
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

ChemicalStructure/PW C000937
type: ChemicalStructure
structure format: SMILES

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Reference/UniProt P39207
type: UnificationXref
id: P39207
db: UniProt

Reference/ChemSpider 9319
type: UnificationXref
id: 9319
db: ChemSpider

Reference/CAS 50-89-5
type: UnificationXref
id: 50-89-5
db: CAS

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/KEGG Compound C00364
type: UnificationXref
id: C00364
db: KEGG Compound

Reference/KEGG Compound C00363
type: UnificationXref
id: C00363
db: KEGG Compound

Reference/PathWhiz PW012939
type: UnificationXref
id: PW012939
db: PathWhiz

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/KEGG Compound C00365
type: UnificationXref
id: C00365
db: KEGG Compound

Compound/Generic323 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: nucleoside triphosphate
stoichiometric coefficient: 1.0

Compound/PW C001035 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thymidine 5'-triphosphate
stoichiometric coefficient: 1.0

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Compound/Generic304 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5,10-methylene-tetrahydrofolate
stoichiometric coefficient: 1.0

dCDP
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001245
xref: Reference/ChemSpider 132961
xref: Reference/KEGG Compound C00705
xref: Reference/ChEBI CHEBI 28846
xref: Reference/CAS 800-73-7
xref: Reference/PubChem-compound 150855
xref: Reference/BioCyc DCDP
chemical formula: C9H15N3O10P2
molecular weight: 387.02325
structure: ChemicalStructure/PW C000962

Reference/KEGG Compound C01342
type: UnificationXref
id: C01342
db: KEGG Compound

Reference/ChEBI CHEBI 28938
type: UnificationXref
id: CHEBI:28938
db: ChEBI

Reference/BioCyc TDP
type: UnificationXref
id: TDP
db: BioCyc

thymidine kinase 1a
type: Protein
cellular location: Cytosol
entity reference: thymidine kinase 1a

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/HMDB HMDB0001202
type: UnificationXref
id: HMDB0001202
db: HMDB

5,10-methylene-tetrahydrofolate
type: SmallMolecule
cellular location: Cytosol
entity reference: 5,10-methylene-tetrahydrofolate

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

deoxynucleoside kinase
type: ProteinReference
xref: Reference/UniProt Q501D4
organism: Arabidopsis thaliana

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

nucleoside-diphosphate kinase 1
type: ProteinReference
xref: Reference/UniProt P39207
organism: Arabidopsis thaliana

UMP/CMP kinase
type: ProteinReference
xref: Reference/UniProt O04905
organism: Arabidopsis thaliana

Reference/BioCyc DCMP
type: UnificationXref
id: DCMP
db: BioCyc

Reference/KEGG Compound C00705
type: UnificationXref
id: C00705
db: KEGG Compound

Reference/ChemSpider 58574
type: UnificationXref
id: 58574
db: ChemSpider

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Compound/PW C000937 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: dCMP
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17013
type: UnificationXref
id: CHEBI:17013
db: ChEBI

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Thymidine 5'-triphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00459
xref: Reference/CAS 365-08-2
xref: Reference/ChEBI CHEBI 18077
xref: Reference/ChemSpider 58493
xref: Reference/PubChem-compound 64968
xref: Reference/HMDB HMDB0001342
xref: Reference/BioCyc TTP
chemical formula: C10H17N2O14P3
molecular weight: 481.98926
structure: ChemicalStructure/PW C001035

Reference/ChemSpider 13343
type: UnificationXref
id: 13343
db: ChemSpider

Thymidine
type: SmallMoleculeReference
xref: Reference/BioCyc THYMIDINE
xref: Reference/ChEBI CHEBI 17748
xref: Reference/CAS 50-89-5
xref: Reference/PubChem-compound 5789
xref: Reference/ChemSpider 5585
xref: Reference/HMDB HMDB0000273
xref: Reference/KEGG Compound C00214
chemical formula: C10H14N2O5
molecular weight: 242.09027
structure: ChemicalStructure/PW C000187

thymidine kinase 1a
type: ProteinReference
xref: Reference/UniProt Q9S750
organism: Arabidopsis thaliana

cytidine deaminase
type: ProteinReference
xref: Reference/UniProt O65896
organism: Arabidopsis thaliana

Reference/BioCyc TTP
type: UnificationXref
id: TTP
db: BioCyc

nucleoside carrier protein
type: ProteinReference
xref: Reference/UniProt Z0Z000

UMP/CMP kinase
type: Protein
cellular location: Cytosol
entity reference: UMP/CMP kinase

thymidylate kinase
type: ProteinReference
xref: Reference/UniProt Q0WW55
organism: Arabidopsis thaliana

Reference/ChEBI CHEBI 17622
type: UnificationXref
id: CHEBI:17622
db: ChEBI

cytidine deaminase
type: Protein
cellular location: Cytosol
entity reference: cytidine deaminase

Reference/ChEBI CHEBI 17748
type: UnificationXref
id: CHEBI:17748
db: ChEBI

ChemicalStructure/PW C000962
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc DCDP
type: UnificationXref
id: DCDP
db: BioCyc

Reference/HMDB HMDB0000012
type: UnificationXref
id: HMDB0000012
db: HMDB

dUMP
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17622
xref: Reference/ChemSpider 58574
xref: Reference/HMDB HMDB0001409
xref: Reference/CAS 964-26-1
xref: Reference/BioCyc DUMP
xref: Reference/PubChem-compound 65063
xref: Reference/KEGG Compound C00365
chemical formula: C9H13N2O8P
molecular weight: 308.04095
structure: ChemicalStructure/PW C001087

Reference/HMDB HMDB0000014
type: UnificationXref
id: HMDB0000014
db: HMDB

Reference/HMDB HMDB0001227
type: UnificationXref
id: HMDB0001227
db: HMDB

Reference/PubChem-compound 150855
type: UnificationXref
id: 150855
db: PubChem-compound

dCTP
type: SmallMoleculeReference
xref: Reference/CAS 2056-98-6
xref: Reference/PubChem-compound 65091
xref: Reference/ChEBI CHEBI 16311
xref: Reference/KEGG Compound C00458
xref: Reference/ChemSpider 58601
xref: Reference/HMDB HMDB0000998
xref: Reference/BioCyc DCTP
chemical formula: C9H16N3O13P3
molecular weight: 466.9896
structure: ChemicalStructure/PW C000790

Reference/BioCyc DCTP
type: UnificationXref
id: DCTP
db: BioCyc

Reference/HMDB HMDB0001342
type: UnificationXref
id: HMDB0001342
db: HMDB

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

nucleoside triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: nucleoside triphosphate

Compound/Generic324 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: nucleoside diphosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15698
type: UnificationXref
id: CHEBI:15698
db: ChEBI

5-Thymidylic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: 5-Thymidylic acid

Deoxyuridine
type: SmallMolecule
cellular location: Cytosol
entity reference: Deoxyuridine

Reference/PubChem-compound 65063
type: UnificationXref
id: 65063
db: PubChem-compound

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000187
type: ChemicalStructure
structure format: SMILES

Compound/PW C000008 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Deoxycytidine
stoichiometric coefficient: 1.0

deoxynucleoside kinase
type: Protein
cellular location: Cytosol
entity reference: deoxynucleoside kinase

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine diphosphate

Reference/CAS 14798-03-9
type: UnificationXref
id: 14798-03-9
db: CAS

dCDP
type: SmallMolecule
cellular location: Cytosol
entity reference: dCDP

ChemicalStructure/PW C001035
type: ChemicalStructure
structure format: SMILES

Reference/UniProt O65896
type: UnificationXref
id: O65896
db: UniProt

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

a 7,8-dihydrofolate
type: SmallMolecule
cellular location: Cytosol
entity reference: a 7,8-dihydrofolate

Reference/ChemSpider 5585
type: UnificationXref
id: 5585
db: ChemSpider

Arabidopsis thaliana
type: BioSource
xref: Reference/TAXONOMY 3702

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Compound/PW C001034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001245
type: UnificationXref
id: HMDB0001245
db: HMDB

ChemicalStructure/PW C000950
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000273
type: UnificationXref
id: HMDB0000273
db: HMDB

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

ChemicalStructure/PW C022608
type: ChemicalStructure
structure format: SMILES
structure data: [NH4+]

Reference/PubChem-compound 9700
type: UnificationXref
id: 9700
db: PubChem-compound

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Compound/Generic225 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: a 7,8-dihydrofolate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Reference/PubChem-compound 65091
type: UnificationXref
id: 65091
db: PubChem-compound

Reference/ChemSpider 132961
type: UnificationXref
id: 132961
db: ChemSpider

Deoxycytidine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Deoxycytidine

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Compound/PW C000007 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Deoxyuridine
stoichiometric coefficient: 1.0

dCTP
type: SmallMolecule
cellular location: Cytosol
entity reference: dCTP

thymidylate kinase
type: Protein
cellular location: Cytosol
entity reference: thymidylate kinase

Reference/UniProt Q501D4
type: UnificationXref
id: Q501D4
db: UniProt

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Reference/ChEBI CHEBI 18077
type: UnificationXref
id: CHEBI:18077
db: ChEBI

2.7.1.74
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000008 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic324 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic323 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000937 Cytosol/Stoichiometry/1.0
right: nucleoside diphosphate
right: dCMP
right: Hydrogen Ion
spontaneous: false
EC number: 2.7.1.74
left: nucleoside triphosphate
left: Deoxycytidine
name: Deoxycytidine + nucleoside triphosphate → Hydrogen Ion + dCMP + nucleoside diphosphate
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 18075
type: UnificationXref
id: CHEBI:18075
db: ChEBI

Reference/PubChem-compound 13712
type: UnificationXref
id: 13712
db: PubChem-compound

Reference/UniProt O04905
type: UnificationXref
id: O04905
db: UniProt

2.7.4.14
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000962 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000937 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: dCDP
spontaneous: false
EC number: 2.7.4.14
left: Adenosine triphosphate
left: dCMP
name: Adenosine triphosphate + dCMP → Adenosine diphosphate + dCDP
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 13711
type: UnificationXref
id: 13711
db: PubChem-compound

Reference/ChEBI CHEBI 16450
type: UnificationXref
id: CHEBI:16450
db: ChEBI

2.7.4.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000962 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000790 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: dCTP
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.4.6
left: Adenosine triphosphate
left: dCDP
name: Adenosine triphosphate + dCDP → Adenosine diphosphate + dCTP
conversion direction: LEFT_TO_RIGHT

3.5.4.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000008 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000007 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C022608 Cytosol/Stoichiometry/1.0
right: Ammonium
right: Deoxyuridine
spontaneous: false
EC number: 3.5.4.5
left: Hydrogen Ion
left: Deoxycytidine
left: Water
name: Deoxycytidine + Hydrogen Ion + Water → Ammonium + Deoxyuridine
conversion direction: LEFT_TO_RIGHT

2.7.1.21
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000007 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001087 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: dUMP
spontaneous: false
EC number: 2.7.1.21
left: Adenosine triphosphate
left: Deoxyuridine
name: Adenosine triphosphate + Deoxyuridine → Adenosine diphosphate + dUMP
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reference/CAS 951-77-9
type: UnificationXref
id: 951-77-9
db: CAS

cytidine deaminase
type: Complex
component stoichiometry: Protein/11643 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: cytidine deaminase

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/ChEBI CHEBI 15918
type: UnificationXref
id: CHEBI:15918
db: ChEBI

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/KEGG Compound C00526
type: UnificationXref
id: C00526
db: KEGG Compound

Reference/BioCyc TMP
type: UnificationXref
id: TMP
db: BioCyc

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

nucleoside triphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00201

Thymidine
type: SmallMolecule
cellular location: Cytosol
entity reference: Thymidine

dCMP
type: SmallMolecule
cellular location: Cytosol
entity reference: dCMP

nucleoside diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00454

2.1.1.45
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000950 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001087 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic304 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic225 Cytosol/Stoichiometry/1.0
right: 5-Thymidylic acid
right: a 7,8-dihydrofolate
spontaneous: false
EC number: 2.1.1.45
left: 5,10-methylene-tetrahydrofolate
left: dUMP
name: 5,10-methylene-tetrahydrofolate + dUMP → 5-Thymidylic acid + a 7,8-dihydrofolate
conversion direction: LEFT_TO_RIGHT

Reaction47671
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000187 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000950 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: 5-Thymidylic acid
right: Adenosine diphosphate
right: Hydrogen Ion
spontaneous: false
left: Adenosine triphosphate
left: Thymidine
name: Adenosine triphosphate + Thymidine → 5-Thymidylic acid + Adenosine diphosphate + Hydrogen Ion
conversion direction: LEFT_TO_RIGHT

2.7.4.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000950 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000987 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: dTDP
spontaneous: false
EC number: 2.7.4.9
left: 5-Thymidylic acid
left: Adenosine triphosphate
name: 5-Thymidylic acid + Adenosine triphosphate → Adenosine diphosphate + dTDP
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00881
type: UnificationXref
id: C00881
db: KEGG Compound

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

Reaction47673
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001035 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000987 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Thymidine 5'-triphosphate
right: Adenosine diphosphate
spontaneous: false
left: Adenosine triphosphate
left: dTDP
name: Adenosine triphosphate + dTDP → Adenosine diphosphate + Thymidine 5'-triphosphate
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 13945
type: UnificationXref
id: 13945
db: PubChem-compound

nucleoside-diphosphate kinase 1
type: Protein
cellular location: Cytosol
entity reference: nucleoside-diphosphate kinase 1

Reference/HMDB HMDB0001274
type: UnificationXref
id: HMDB0001274
db: HMDB

Reference/CAS 491-97-4
type: UnificationXref
id: 491-97-4
db: CAS

Reference/ChEBI CHEBI 16311
type: UnificationXref
id: CHEBI:16311
db: ChEBI

Pyrimidine Deoxyribonucleosides Salvage
type: Pathway
pathway order: PathwayEnzymeReaction/224595
pathway order: PathwayEnzymeReaction/224594
pathway order: PathwayEnzymeReaction/224593
pathway order: PathwayTransport/224599
pathway order: PathwayEnzymeReaction/224592
pathway order: PathwayTransport/224598
pathway order: PathwayEnzymeReaction/224588
pathway order: PathwayEnzymeReaction/224587
pathway order: PathwayEnzymeReaction/224585
pathway order: PathwayEnzymeReaction/224589
pathway order: PathwayEnzymeReaction/224591
pathway component: 2.1.1.45
pathway component: ReactionCatalysis37811
pathway component: Reaction47671
pathway component: ReactionCatalysis37810
pathway component: 2.7.4.9
pathway component: Reaction47673
pathway component: 2.7.1.74
pathway component: 2.7.4.14
pathway component: 2.7.4.6
pathway component: 3.5.4.5
pathway component: 2.7.1.21
pathway component: ReactionCatalysis37809
pathway component: Transport903
pathway component: TransportCatalysis804
pathway component: TransportCatalysis803
pathway component: Transport904
pathway component: ReactionCatalysis37813
pathway component: ReactionCatalysis37812
pathway component: ReactionCatalysis37815
pathway component: ReactionCatalysis37814
pathway component: ReactionCatalysis37808
pathway component: ReactionCatalysis37807
xref: Reference/PathWhiz PW012939
xref: Reference/SMPDB SMP0012077
organism: Arabidopsis thaliana

Reference/ChemSpider 58601
type: UnificationXref
id: 58601
db: ChemSpider

nucleoside carrier protein
type: Protein
entity reference: nucleoside carrier protein

Reference/PubChem-compound 16741146
type: UnificationXref
id: 16741146
db: PubChem-compound

ChemicalStructure/PW C000987
type: ChemicalStructure
structure format: SMILES

Compound/PW C000187 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thymidine
stoichiometric coefficient: 1.0

Compound/PW C000790 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: dCTP
stoichiometric coefficient: 1.0

Reference/CAS 951-78-0
type: UnificationXref
id: 951-78-0
db: CAS

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/HMDB HMDB0000998
type: UnificationXref
id: HMDB0000998
db: HMDB

Reference/UniProt Z0Z000
type: UnificationXref
id: Z0Z000
db: UniProt

ReactionCatalysis37813
type: Catalysis
controller: thymidine kinase 1a
controlled: Reaction47671
control type: ACTIVATION

Ammonium
type: SmallMolecule
cellular location: Cytosol
entity reference: Ammonium

ReactionCatalysis37812
type: Catalysis
controller: DHFR-TS
controlled: 2.1.1.45
control type: ACTIVATION

ReactionCatalysis37815
type: Catalysis
controller: nucleoside-diphosphate kinase 1
controlled: Reaction47673
control type: ACTIVATION

ReactionCatalysis37814
type: Catalysis
controller: thymidylate kinase
controlled: 2.7.4.9
control type: ACTIVATION

Compound/PW C000987 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: dTDP
stoichiometric coefficient: 1.0

DHFR-TS
type: Protein
cellular location: Cytosol
entity reference: DHFR-TS

Reference/BioCyc DEOXYCYTIDINE
type: UnificationXref
id: DEOXYCYTIDINE
db: BioCyc

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Reference/HMDB HMDB0041827
type: UnificationXref
id: HMDB0041827
db: HMDB

a 7,8-dihydrofolate
type: SmallMoleculeReference

ReactionCatalysis37811
type: Catalysis
controller: thymidine kinase 1a
controlled: 2.7.1.21
control type: ACTIVATION

ReactionCatalysis37810
type: Catalysis
controller: cytidine deaminase
controlled: 3.5.4.5
control type: ACTIVATION

DHFR-TS
type: ProteinReference
xref: Reference/UniProt Q05762
organism: Arabidopsis thaliana

Deoxycytidine
type: SmallMolecule
cellular location: Cytosol
entity reference: Deoxycytidine

Reference/PubChem-compound 5789
type: UnificationXref
id: 5789
db: PubChem-compound

Thymidine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Thymidine

Reference/BioCyc DEOXYURIDINE
type: UnificationXref
id: DEOXYURIDINE
db: BioCyc

Compound/PW C022608 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonium
stoichiometric coefficient: 1.0

ReactionCatalysis37809
type: Catalysis
controller: nucleoside-diphosphate kinase 1
controlled: 2.7.4.6
control type: ACTIVATION

Transport903
type: Transport
participant stoichiometry: Compound/PW C000008 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000008 Cytosol/Stoichiometry/1.0
right: Deoxycytidine
spontaneous: true
left: Deoxycytidine
name: Deoxycytidine (→) Transport: Arabidopsis thaliana, Cell, Extracellular Space to Arabidopsis thaliana, Cell, Cytosol
conversion direction: REVERSIBLE

Transport904
type: Transport
participant stoichiometry: Compound/PW C000187 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000187 Extracellular Space/Stoichiometry/1.0
right: Thymidine
spontaneous: true
left: Thymidine
name: Thymidine (→) Transport: Arabidopsis thaliana, Cell, Extracellular Space to Arabidopsis thaliana, Cell, Cytosol
conversion direction: REVERSIBLE

ReactionCatalysis37808
type: Catalysis
controller: UMP/CMP kinase
controlled: 2.7.4.14
control type: ACTIVATION

ReactionCatalysis37807
type: Catalysis
controller: deoxynucleoside kinase
controlled: 2.7.1.74
control type: ACTIVATION