Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Reference/ChemSpider 388357
type: UnificationXref
id: 388357
db: ChemSpider

Reference/TAXONOMY 3702
type: UnificationXref
id: 3702
db: TAXONOMY

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Compound/PW C000174 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinic acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 388353
type: UnificationXref
id: 388353
db: ChemSpider

Compound/PW C000075 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glyoxylic acid
stoichiometric coefficient: 1.0

Transport914
type: Transport
participant stoichiometry: Compound/PW C001063 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001063 Cytosol/Stoichiometry/1.0
right: 3-Hydroxy-3-methylglutaryl-CoA
spontaneous: false
left: 3-Hydroxy-3-methylglutaryl-CoA
name: 3-Hydroxy-3-methylglutaryl-CoA (→) Transport: Arabidopsis thaliana, Cell, Cytosol to Arabidopsis thaliana, Cell, Mitochondrial Matrix
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

Transport913
type: Transport
participant stoichiometry: Compound/PW C000972 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000972 Mitochondrial Matrix/Stoichiometry/1.0
right: Succinic acid semialdehyde
spontaneous: false
left: Succinic acid semialdehyde
name: Succinic acid semialdehyde (→) Transport: Arabidopsis thaliana, Cell, Mitochondrial Matrix to Arabidopsis thaliana, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Compound/PW C000972 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinic acid semialdehyde
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Arginine and Proline Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway6591
pathway component: SubPathwayInteraction6591
name: SubPathway

Alanine, Aspartate, and Glutamate Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway6590
pathway component: SubPathwayInteraction6590
name: SubPathway

Transport912
type: Transport
participant stoichiometry: Compound/PW C000071 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000071 Mitochondrial Matrix/Stoichiometry/1.0
right: γ-Aminobutyric acid
spontaneous: false
left: γ-Aminobutyric acid
name: γ-Aminobutyric acid (→) Transport: Arabidopsis thaliana, Cytosol to Arabidopsis thaliana, Cell, Mitochondrial Matrix
conversion direction: LEFT_TO_RIGHT

Acetyl-CoA
type: SmallMolecule
cellular location: Cytosol
entity reference: Acetyl-CoA
name: SubPathwayOutput

Succinic acid semialdehyde
type: SmallMolecule
cellular location: Cytosol
entity reference: Succinic acid semialdehyde

Reference/UniProt Q9SAK4
type: UnificationXref
id: Q9SAK4
db: UniProt

Reference/PubChem-compound 119
type: UnificationXref
id: 119
db: PubChem-compound

Fatty Acid Degradation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway6594
pathway component: SubPathwayInteraction6594
name: SubPathway

4.1.1.15
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000095 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000071 Cytosol/Stoichiometry/1.0
right: γ-Aminobutyric acid
right: Carbon dioxide
spontaneous: false
EC number: 4.1.1.15
left: L-Glutamic acid
name: L-Glutamic acid → Carbon dioxide + γ-Aminobutyric acid
conversion direction: LEFT_TO_RIGHT

Pyruvate Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway6593
pathway component: SubPathwayInteraction6593
name: SubPathway

Reaction48167
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000164 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000972 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000071 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000105 Mitochondrial Matrix/Stoichiometry/1.0
right: Succinic acid semialdehyde
right: L-Alanine
spontaneous: false
left: γ-Aminobutyric acid
left: Pyruvic acid
name: Pyruvic acid + γ-Aminobutyric acid ↔ L-Alanine + Succinic acid semialdehyde
conversion direction: REVERSIBLE

Vitamin B6 Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway6592
pathway component: SubPathwayInteraction6592
name: SubPathway

Reaction48168
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000075 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000078 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000972 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000071 Mitochondrial Matrix/Stoichiometry/1.0
right: Succinic acid semialdehyde
right: Glycine
spontaneous: false
left: γ-Aminobutyric acid
left: Glyoxylic acid
name: Glyoxylic acid + γ-Aminobutyric acid → Glycine + Succinic acid semialdehyde
conversion direction: LEFT_TO_RIGHT

SubPathwayInteraction6590
type: Interaction
name: SubPathwayReaction
name: SubPathway6590Reaction
participant: L-Glutamic acid

Reaction48169
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000972 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000561 Cytosol/Stoichiometry/1.0
right: 4-Hydroxybutyric acid
right: NADPH
spontaneous: false
left: NADP
left: Succinic acid semialdehyde
name: NADP + Succinic acid semialdehyde ↔ 4-Hydroxybutyric acid + NADPH
conversion direction: REVERSIBLE

SubPathwayInteraction6591
type: Interaction
name: SubPathway6591Reaction
name: SubPathwayReaction
participant: γ-Aminobutyric acid

SubPathwayInteraction6592
type: Interaction
name: SubPathway6592Reaction
name: SubPathwayReaction
participant: Succinic acid semialdehyde

Compound/PW C000143 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

SubPathwayInteraction6593
type: Interaction
name: SubPathwayReaction
name: SubPathway6593Reaction
participant: Acetoacetyl-CoA

SubPathwayInteraction6594
type: Interaction
name: SubPathway6594Reaction
name: SubPathwayReaction
participant: Acetyl-CoA

Reference/ChEBI CHEBI 16265
type: UnificationXref
id: CHEBI:16265
db: ChEBI

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/CAS 591-81-1
type: UnificationXref
id: 591-81-1
db: CAS

Pyruvic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 1060
xref: Reference/HMDB HMDB0000243
xref: Reference/CAS 127-17-3
xref: Reference/BioCyc PYRUVATE
xref: Reference/KEGG Compound C00022
xref: Reference/ChEBI CHEBI 32816
xref: Reference/ChemSpider 1031
chemical formula: C3H4O3
molecular weight: 88.016045
structure: ChemicalStructure/PW C000164

Acetoacetic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15344
xref: Reference/HMDB HMDB0000060
xref: Reference/BioCyc 3-KETOBUTYRATE
xref: Reference/KEGG Compound C00164
xref: Reference/PubChem-compound 96
xref: Reference/CAS 541-50-4
xref: Reference/ChemSpider 94
chemical formula: C4H6O3
molecular weight: 102.03169
structure: ChemicalStructure/PW C000042

1.1.1.157
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000904 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001142 Cytosol/Stoichiometry/1.0
right: Acetoacetyl-CoA
right: Hydrogen Ion
right: NADPH
spontaneous: false
EC number: 1.1.1.157
left: NADP
left: 3-Hydroxybutyryl-CoA
name: 3-Hydroxybutyryl-CoA + NADP ↔ Acetoacetyl-CoA + Hydrogen Ion + NADPH
conversion direction: REVERSIBLE

Reference/UniProt P54873
type: UnificationXref
id: P54873
db: UniProt

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Reference/CAS 1553-55-5
type: UnificationXref
id: 1553-55-5
db: CAS

Reference/BioCyc CPD-3193
type: UnificationXref
id: CPD-3193
db: BioCyc

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/KEGG Compound C00334
type: UnificationXref
id: C00334
db: KEGG Compound

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/KEGG Compound C00332
type: UnificationXref
id: C00332
db: KEGG Compound

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/PubChem-compound 440045
type: UnificationXref
id: 440045
db: PubChem-compound

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

4.1.3.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001063 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000042 Mitochondrial Matrix/Stoichiometry/1.0
right: Acetyl-CoA
right: Acetoacetic acid
spontaneous: false
EC number: 4.1.3.4
left: 3-Hydroxy-3-methylglutaryl-CoA
name: 3-Hydroxy-3-methylglutaryl-CoA → Acetoacetic acid + Acetyl-CoA
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis39518
type: Catalysis
controller: hydroxymethylglutaryl-CoA synthase
controlled: Reaction49393
control type: ACTIVATION

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Reference/ChemSpider 5735
type: UnificationXref
id: 5735
db: ChemSpider

Compound/PW C001142 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetoacetyl-CoA
stoichiometric coefficient: 1.0

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Glyoxylate/succinic semialdehyde reductase 1
type: Protein
cellular location: Cytosol
entity reference: Glyoxylate/succinic semialdehyde reductase 1

ChemicalStructure/PW C000561
type: ChemicalStructure
structure format: SMILES
structure data: OCCCC(O)=O

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

Compound/PW C001063 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Hydroxy-3-methylglutaryl-CoA
stoichiometric coefficient: 1.0

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

3-hydroxybutyryl-CoA dehydrogenase
type: Protein
cellular location: Cytosol
entity reference: 3-hydroxybutyryl-CoA dehydrogenase

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

ReactionCatalysis7184
type: Catalysis
controller: Succinate-semialdehyde dehydrogenase, mitochondrial
controlled: 1.2.1.24
control type: ACTIVATION

3-hydroxy-3-methylglutaryl-CoA transporter
type: Protein
entity reference: 3-hydroxy-3-methylglutaryl-CoA transporter

Hydroxymethylglutaryl-CoA lyase, mitochondrial
type: ProteinReference
xref: Reference/UniProt O81027
organism: Arabidopsis thaliana

Reference/BioCyc GLY
type: UnificationXref
id: GLY
db: BioCyc

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

succinate semialdehyde transporter
type: Protein
entity reference: succinate semialdehyde transporter

Compound/PW C000146 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

γ-Aminobutyric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: γ-Aminobutyric acid
name: SubPathwayOutput

Reference/ChEBI CHEBI 16977
type: UnificationXref
id: CHEBI:16977
db: ChEBI

Reference/KEGG Compound C00232
type: UnificationXref
id: C00232
db: KEGG Compound

Carbon dioxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbon dioxide

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

ReactionCatalysis38294
type: Catalysis
controller: Gamma-aminobutyrate transaminase POP2, mitochondrial
controlled: Reaction48167
control type: ACTIVATION

ReactionCatalysis38293
type: Catalysis
controller: Glutamate decarboxylase 1
controlled: 4.1.1.15
control type: ACTIVATION

Reference/UniProt Q94CE5
type: UnificationXref
id: Q94CE5
db: UniProt

ReactionCatalysis38296
type: Catalysis
controller: Glyoxylate/succinic semialdehyde reductase 1
controlled: Reaction48169
control type: ACTIVATION

ReactionCatalysis38295
type: Catalysis
controller: Gamma-aminobutyrate transaminase POP2, mitochondrial
controlled: Reaction48168
control type: ACTIVATION

Reference/KEGG Compound C00356
type: UnificationXref
id: C00356
db: KEGG Compound

ReactionCatalysis38298
type: Catalysis
controller: acetyl-CoA acetyltransferase 1
controlled: 2.3.1.9
control type: ACTIVATION

Reference/BioCyc SUC
type: UnificationXref
id: SUC
db: BioCyc

ReactionCatalysis38297
type: Catalysis
controller: 3-hydroxybutyryl-CoA dehydrogenase
controlled: 1.1.1.157
control type: ACTIVATION

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

γ-Aminobutyric acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000112
xref: Reference/ChemSpider 116
xref: Reference/PubChem-compound 119
xref: Reference/CAS 56-12-2
xref: Reference/BioCyc 4-AMINO-BUTYRATE
xref: Reference/ChEBI CHEBI 16865
xref: Reference/KEGG Compound C00334
chemical formula: C4H9NO2
molecular weight: 103.06333
structure: ChemicalStructure/PW C000071

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

Succinic acid semialdehyde
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Succinic acid semialdehyde
name: SubPathwayInput

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Reference/CAS 692-29-5
type: UnificationXref
id: 692-29-5
db: CAS

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Glycine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000123
xref: Reference/BioCyc GLY
xref: Reference/ChemSpider 730
xref: Reference/PubChem-compound 5257127
xref: Reference/CAS 56-40-6
xref: Reference/ChEBI CHEBI 15428
xref: Reference/KEGG Compound C00037
chemical formula: C2H5NO2
molecular weight: 75.03203
structure: ChemicalStructure/PW C000078

L-Alanine
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: L-Alanine

Glyoxylic acid
type: SmallMoleculeReference
xref: Reference/BioCyc GLYOX
xref: Reference/ChemSpider 740
xref: Reference/CAS 298-12-4
xref: Reference/HMDB HMDB0000119
xref: Reference/PubChem-compound 760
xref: Reference/ChEBI CHEBI 16891
xref: Reference/KEGG Compound C00048
chemical formula: C2H2O3
molecular weight: 74.0004
structure: ChemicalStructure/PW C000075

Reference/ChemSpider 94
type: UnificationXref
id: 94
db: ChemSpider

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Compound/PW C000940 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16865
type: UnificationXref
id: CHEBI:16865
db: ChEBI

Gamma-aminobutyrate transaminase POP2, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Gamma-aminobutyrate transaminase POP2, mitochondrial

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Reference/BioCyc L-ALPHA-ALANINE
type: UnificationXref
id: L-ALPHA-ALANINE
db: BioCyc

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/CAS 56-41-7
type: UnificationXref
id: 56-41-7
db: CAS

Butanoate Metabolism
type: Pathway
pathway order: PathwayEnzymeReaction/262376
pathway order: PathwayEnzymeReaction/262387
pathway order: PathwayEnzymeReaction/262375
pathway order: PathwaySubPathway/6590
pathway order: PathwayEnzymeReaction/262385
pathway order: PathwaySubPathway/6592
pathway order: PathwaySubPathway/6591
pathway order: PathwaySubPathway/6594
pathway order: PathwayTransport/262377
pathway order: PathwayEnzymeReaction/262378
pathway order: PathwaySubPathway/6593
pathway order: PathwayTransport/262372
pathway order: PathwayTransport/262383
pathway order: PathwayEnzymeReaction/262373
pathway order: PathwayEnzymeReaction/262382
pathway order: PathwayEnzymeReaction/262370
pathway order: PathwayEnzymeReaction/262381
pathway component: ReactionCatalysis7184
pathway component: 2.3.1.9
pathway component: ReactionCatalysis38294
pathway component: ReactionCatalysis38293
pathway component: ReactionCatalysis38296
pathway component: ReactionCatalysis38295
pathway component: ReactionCatalysis38298
pathway component: ReactionCatalysis38297
pathway component: Transport914
pathway component: Transport913
pathway component: TransportCatalysis812
pathway component: TransportCatalysis811
pathway component: Arginine and Proline Metabolism
pathway component: TransportCatalysis810
pathway component: 1.2.1.24
pathway component: 4.1.3.4
pathway component: Alanine, Aspartate, and Glutamate Metabolism
pathway component: Transport912
pathway component: ReactionCatalysis39518
pathway component: Reaction49393
pathway component: Fatty Acid Degradation
pathway component: 4.1.1.15
pathway component: Pyruvate Metabolism
pathway component: Reaction48167
pathway component: Vitamin B6 Metabolism
pathway component: Reaction48168
pathway component: Reaction48169
pathway component: ReactionCatalysis7238
pathway component: 1.1.1.157
xref: Reference/SMPDB SMP0012467
xref: Reference/PathWhiz PW013330
organism: Arabidopsis thaliana

NADH
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: NADH

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

NADPH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADPH

Reference/ChemSpider 1031
type: UnificationXref
id: 1031
db: ChemSpider

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Reference/PubChem-compound 5257127
type: UnificationXref
id: 5257127
db: PubChem-compound

Reference/GENE ONTOLOGY GO 0005759
type: UnificationXref
id: GO:0005759
db: GENE ONTOLOGY

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Acetoacetyl-CoA
type: SmallMolecule
cellular location: Cytosol
entity reference: Acetoacetyl-CoA
name: SubPathwayOutput

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

GABA permease
type: Protein
entity reference: GABA permease

acetyl-CoA acetyltransferase 1
type: Protein
cellular location: Cytosol
entity reference: acetyl-CoA acetyltransferase 1

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Reference/ChEBI CHEBI 15741
type: UnificationXref
id: CHEBI:15741
db: ChEBI

ChemicalStructure/PW C000904
type: ChemicalStructure
structure format: SMILES

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Coenzyme A
type: SmallMolecule
cellular location: Cytosol
entity reference: Coenzyme A

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Glutamate decarboxylase 1
type: Protein
cellular location: Cytosol
entity reference: Glutamate decarboxylase 1

Reference/PubChem-compound 1112
type: UnificationXref
id: 1112
db: PubChem-compound

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

ChemicalStructure/PW C000105
type: ChemicalStructure
structure format: SMILES
structure data: C[C@H](N)C(O)=O

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Compound/PW C000071 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: γ-Aminobutyric acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5950
type: UnificationXref
id: 5950
db: PubChem-compound

Reference/PubChem-compound 1110
type: UnificationXref
id: 1110
db: PubChem-compound

Hydrogen Ion
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Hydrogen Ion

Reference/HMDB HMDB0000112
type: UnificationXref
id: HMDB0000112
db: HMDB

Reference/ChemSpider 116
type: UnificationXref
id: 116
db: ChemSpider

Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Acetoacetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETOACETYL-COA
xref: Reference/PubChem-compound 439214
xref: Reference/ChEBI CHEBI 15345
xref: Reference/CAS 1420-36-6
xref: Reference/HMDB HMDB0001484
xref: Reference/KEGG Compound C00332
xref: Reference/ChemSpider 388353
chemical formula: C25H40N7O18P3S
molecular weight: 851.13635
structure: ChemicalStructure/PW C001142

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Reference/BioCyc 3-HYDROXY-3-METHYL-GLUTARYL-COA
type: UnificationXref
id: 3-HYDROXY-3-METHYL-GLUTARYL-COA
db: BioCyc

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

TransportCatalysis812
type: Catalysis
controller: 3-hydroxy-3-methylglutaryl-CoA transporter
controlled: Transport914
control type: ACTIVATION

TransportCatalysis811
type: Catalysis
controller: succinate semialdehyde transporter
controlled: Transport913
control type: ACTIVATION

TransportCatalysis810
type: Catalysis
controller: GABA permease
controlled: Transport912
control type: ACTIVATION

Compound/PW C000078 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glycine
stoichiometric coefficient: 1.0

Succinic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000254
xref: Reference/CAS 110-15-6
xref: Reference/ChEBI CHEBI 15741
xref: Reference/KEGG Compound C00042
xref: Reference/ChemSpider 1078
xref: Reference/PubChem-compound 1110
xref: Reference/BioCyc SUC
chemical formula: C4H6O4
molecular weight: 118.02661
structure: ChemicalStructure/PW C000174

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Succinic acid semialdehyde
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001259
xref: Reference/BioCyc SUCC-S-ALD
xref: Reference/ChemSpider 1080
xref: Reference/CAS 692-29-5
xref: Reference/KEGG Compound C00232
xref: Reference/PubChem-compound 1112
xref: Reference/ChEBI CHEBI 16265
chemical formula: C4H6O3
molecular weight: 102.03169
structure: ChemicalStructure/PW C000972

Reference/KEGG Compound C00022
type: UnificationXref
id: C00022
db: KEGG Compound

Reference/HMDB HMDB0000119
type: UnificationXref
id: HMDB0000119
db: HMDB

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

L-Glutamic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Glutamic acid
name: SubPathwayOutput

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

Reference/HMDB HMDB0000123
type: UnificationXref
id: HMDB0000123
db: HMDB

Reference/UniProt Q8S4Y1
type: UnificationXref
id: Q8S4Y1
db: UniProt

Reference/HMDB HMDB0000243
type: UnificationXref
id: HMDB0000243
db: HMDB

Reference/CAS 298-12-4
type: UnificationXref
id: 298-12-4
db: CAS

Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

NADP
type: SmallMolecule
cellular location: Cytosol
entity reference: NADP

Succinate-semialdehyde dehydrogenase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q9SAK4
organism: Arabidopsis thaliana

Gamma-aminobutyrate transaminase POP2, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q94CE5
organism: Arabidopsis thaliana

Glyoxylate/succinic semialdehyde reductase 1
type: ProteinReference
xref: Reference/UniProt Q9LSV0
organism: Arabidopsis thaliana

4-Hydroxybutyric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: 4-Hydroxybutyric acid

Reference/BioCyc SUCC-S-ALD
type: UnificationXref
id: SUCC-S-ALD
db: BioCyc

Compound/PW C001063 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Hydroxy-3-methylglutaryl-CoA
stoichiometric coefficient: 1.0

Reference/BioCyc 3-KETOBUTYRATE
type: UnificationXref
id: 3-KETOBUTYRATE
db: BioCyc

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 760
type: UnificationXref
id: 760
db: PubChem-compound

Reference/ChEBI CHEBI 16891
type: UnificationXref
id: CHEBI:16891
db: ChEBI

Reference/KEGG Compound C00037
type: UnificationXref
id: C00037
db: KEGG Compound

Compound/PW C000071 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: γ-Aminobutyric acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Reference/BioCyc 2-METHYL-3-HYDROXY-BUTYRYL-COA
type: UnificationXref
id: 2-METHYL-3-HYDROXY-BUTYRYL-COA
db: BioCyc

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000254
type: UnificationXref
id: HMDB0000254
db: HMDB

Reference/ChEBI CHEBI 30830
type: UnificationXref
id: CHEBI:30830
db: ChEBI

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

ChemicalStructure/PW C000174
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(O)=O

ChemicalStructure/PW C001142
type: ChemicalStructure
structure format: SMILES

Reference/CAS 2871-66-1
type: UnificationXref
id: 2871-66-1
db: CAS

ChemicalStructure/PW C000972
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC=O

Reference/KEGG Compound C00041
type: UnificationXref
id: C00041
db: KEGG Compound

GABA permease
type: ProteinReference
xref: Reference/UniProt Q9ZU50

1.2.1.24
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000972 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000174 Mitochondrial Matrix/Stoichiometry/1.0
right: Succinic acid
right: NADH
right: Hydrogen Ion
spontaneous: false
EC number: 1.2.1.24
left: Succinic acid semialdehyde
left: Water
left: NAD
name: NAD + Succinic acid semialdehyde + Water → Hydrogen Ion + NADH + Succinic acid
conversion direction: LEFT_TO_RIGHT

Glyoxylic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Glyoxylic acid

Mitochondrial Matrix
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005759

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Reference/SMPDB SMP0012467
type: UnificationXref
id: SMP0012467
db: SMPDB

Reference/KEGG Compound C00164
type: UnificationXref
id: C00164
db: KEGG Compound

Reference/KEGG Compound C00042
type: UnificationXref
id: C00042
db: KEGG Compound

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Compound/PW C000561 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-Hydroxybutyric acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 1078
type: UnificationXref
id: 1078
db: ChemSpider

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

Compound/PW C000904 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Hydroxybutyryl-CoA
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00048
type: UnificationXref
id: C00048
db: KEGG Compound

Reference/ChEBI CHEBI 15452
type: UnificationXref
id: CHEBI:15452
db: ChEBI

Reference/ChemSpider 389056
type: UnificationXref
id: 389056
db: ChemSpider

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Reference/KEGG Compound C03561
type: UnificationXref
id: C03561
db: KEGG Compound

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

Reference/ChemSpider 1080
type: UnificationXref
id: 1080
db: ChemSpider

3-Hydroxy-3-methylglutaryl-CoA
type: SmallMolecule
cellular location: Cytosol
entity reference: 3-Hydroxy-3-methylglutaryl-CoA

hydroxymethylglutaryl-CoA synthase
type: ProteinReference
xref: Reference/UniProt P54873
organism: Arabidopsis thaliana

4-Hydroxybutyric acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 30830
xref: Reference/HMDB HMDB0000710
xref: Reference/KEGG Compound C00989
xref: Reference/BioCyc CPD-3193
xref: Reference/PubChem-compound 10413
xref: Reference/CAS 591-81-1
xref: Reference/ChemSpider 9984
chemical formula: C4H8O3
molecular weight: 104.04734
structure: ChemicalStructure/PW C000561

3-hydroxy-3-methylglutaryl-CoA transporter
type: ProteinReference
xref: Reference/UniProt Z0Z000

Reference/UniProt Q9ZU50
type: UnificationXref
id: Q9ZU50
db: UniProt

succinate semialdehyde transporter
type: ProteinReference
xref: Reference/UniProt Z0Z000

Compound/PW C000105 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Alanine
stoichiometric coefficient: 1.0

acetyl-CoA acetyltransferase 1
type: ProteinReference
xref: Reference/UniProt Q8S4Y1
organism: Arabidopsis thaliana

3-hydroxybutyryl-CoA dehydrogenase
type: ProteinReference
organism: Arabidopsis thaliana

Reference/BioCyc ACETOACETYL-COA
type: UnificationXref
id: ACETOACETYL-COA
db: BioCyc

Glycine
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Glycine

Hydroxymethylglutaryl-CoA lyase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Hydroxymethylglutaryl-CoA lyase, mitochondrial

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Arabidopsis thaliana
type: BioSource
xref: Reference/TAXONOMY 3702

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Succinate-semialdehyde dehydrogenase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Succinate-semialdehyde dehydrogenase, mitochondrial

Reference/BioCyc GLYOX
type: UnificationXref
id: GLYOX
db: BioCyc

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

3-Hydroxy-3-methylglutaryl-CoA
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15467
xref: Reference/ChemSpider 388357
xref: Reference/CAS 1553-55-5
xref: Reference/BioCyc 3-HYDROXY-3-METHYL-GLUTARYL-COA
xref: Reference/KEGG Compound C00356
xref: Reference/HMDB HMDB0001375
xref: Reference/PubChem-compound 439218
chemical formula: C27H44N7O20P3S
molecular weight: 911.1575
structure: ChemicalStructure/PW C001063

Reference/CAS 127-17-3
type: UnificationXref
id: 127-17-3
db: CAS

Reference/PubChem-compound 439214
type: UnificationXref
id: 439214
db: PubChem-compound

Reference/HMDB HMDB0000710
type: UnificationXref
id: HMDB0000710
db: HMDB

Pyruvic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Pyruvic acid

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Reference/HMDB HMDB0001484
type: UnificationXref
id: HMDB0001484
db: HMDB

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Reference/PubChem-compound 439218
type: UnificationXref
id: 439218
db: PubChem-compound

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

Reference/UniProt Q42521
type: UnificationXref
id: Q42521
db: UniProt

Compound/PW C000940 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 2.0

Compound/PW C000095 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Reference/KEGG Compound C00989
type: UnificationXref
id: C00989
db: KEGG Compound

Reference/CAS 56-40-6
type: UnificationXref
id: 56-40-6
db: CAS

NAD
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: NAD

γ-Aminobutyric acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: γ-Aminobutyric acid

ChemicalStructure/PW C000164
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)C(O)=O

ChemicalStructure/PW C000042
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)CC(O)=O

Reference/HMDB HMDB0001259
type: UnificationXref
id: HMDB0001259
db: HMDB

Reference/ChEBI CHEBI 15428
type: UnificationXref
id: CHEBI:15428
db: ChEBI

Reference/HMDB HMDB0000161
type: UnificationXref
id: HMDB0000161
db: HMDB

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/PathWhiz PW013330
type: UnificationXref
id: PW013330
db: PathWhiz

Reference/HMDB HMDB0001375
type: UnificationXref
id: HMDB0001375
db: HMDB

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Acetoacetic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Acetoacetic acid

L-Alanine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00041
xref: Reference/ChemSpider 5735
xref: Reference/ChEBI CHEBI 16977
xref: Reference/BioCyc L-ALPHA-ALANINE
xref: Reference/HMDB HMDB0000161
xref: Reference/CAS 56-41-7
xref: Reference/PubChem-compound 5950
chemical formula: C3H7NO2
molecular weight: 89.047676
structure: ChemicalStructure/PW C000105

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

3-Hydroxy-3-methylglutaryl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: 3-Hydroxy-3-methylglutaryl-CoA

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

3-Hydroxybutyryl-CoA
type: SmallMoleculeReference
xref: Reference/CAS 2871-66-1
xref: Reference/KEGG Compound C03561
xref: Reference/PubChem-compound 440045
xref: Reference/HMDB HMDB0001166
xref: Reference/ChEBI CHEBI 15452
xref: Reference/BioCyc 2-METHYL-3-HYDROXY-BUTYRYL-COA
xref: Reference/ChemSpider 389056
chemical formula: C25H42N7O18P3S
molecular weight: 853.152
structure: ChemicalStructure/PW C000904

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reference/ChemSpider 730
type: UnificationXref
id: 730
db: ChemSpider

Reference/CAS 110-15-6
type: UnificationXref
id: 110-15-6
db: CAS

Water
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Water

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Reference/ChEBI CHEBI 32816
type: UnificationXref
id: CHEBI:32816
db: ChEBI

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/CAS 1420-36-6
type: UnificationXref
id: 1420-36-6
db: CAS

ChemicalStructure/PW C001063
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/BioCyc PYRUVATE
type: UnificationXref
id: PYRUVATE
db: BioCyc

Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Compound/PW C000972 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinic acid semialdehyde
stoichiometric coefficient: 1.0

3-Hydroxybutyryl-CoA
type: SmallMolecule
cellular location: Cytosol
entity reference: 3-Hydroxybutyryl-CoA

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Compound/PW C000042 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetoacetic acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000060
type: UnificationXref
id: HMDB0000060
db: HMDB

Reference/PubChem-compound 96
type: UnificationXref
id: 96
db: PubChem-compound

ReactionCatalysis7238
type: Catalysis
controller: Hydroxymethylglutaryl-CoA lyase, mitochondrial
controlled: 4.1.3.4
control type: ACTIVATION

2.3.1.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001099 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Cytosol/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001142 Cytosol/Stoichiometry/1.0
right: Acetyl-CoA
spontaneous: false
EC number: 2.3.1.9
left: Coenzyme A
left: Acetoacetyl-CoA
name: Acetoacetyl-CoA + Coenzyme A ↔ 2 Acetyl-CoA
conversion direction: REVERSIBLE

Reference/ChEBI CHEBI 15344
type: UnificationXref
id: CHEBI:15344
db: ChEBI

Reference/ChEBI CHEBI 15467
type: UnificationXref
id: CHEBI:15467
db: ChEBI

Reference/ChEBI CHEBI 15345
type: UnificationXref
id: CHEBI:15345
db: ChEBI

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

Reference/CAS 56-12-2
type: UnificationXref
id: 56-12-2
db: CAS

Succinic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Succinic acid

Reference/ChemSpider 9984
type: UnificationXref
id: 9984
db: ChemSpider

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

ChemicalStructure/PW C000075
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C=O

Compound/PW C001099 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

Reference/BioCyc 4-AMINO-BUTYRATE
type: UnificationXref
id: 4-AMINO-BUTYRATE
db: BioCyc

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/UniProt Z0Z000
type: UnificationXref
id: Z0Z000
db: UniProt

ChemicalStructure/PW C000078
type: ChemicalStructure
structure format: SMILES
structure data: NCC(O)=O

Reference/CAS 541-50-4
type: UnificationXref
id: 541-50-4
db: CAS

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

ChemicalStructure/PW C000071
type: ChemicalStructure
structure format: SMILES
structure data: NCCCC(O)=O

Reference/HMDB HMDB0001166
type: UnificationXref
id: HMDB0001166
db: HMDB

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Reference/PubChem-compound 1060
type: UnificationXref
id: 1060
db: PubChem-compound

Reaction49393
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001099 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001063 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001142 Cytosol/Stoichiometry/1.0
right: Coenzyme A
right: 3-Hydroxy-3-methylglutaryl-CoA
spontaneous: false
left: Acetoacetyl-CoA
left: Acetyl-CoA
left: Water
name: Acetoacetyl-CoA + Acetyl-CoA + Water → 3-Hydroxy-3-methylglutaryl-CoA + Coenzyme A
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Compound/PW C001316 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Compound/PW C000164 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 10413
type: UnificationXref
id: 10413
db: PubChem-compound

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

hydroxymethylglutaryl-CoA synthase
type: Protein
cellular location: Cytosol
entity reference: hydroxymethylglutaryl-CoA synthase

Acetyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Acetyl-CoA

Reference/ChemSpider 740
type: UnificationXref
id: 740
db: ChemSpider

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

Reference/UniProt Q9LSV0
type: UnificationXref
id: Q9LSV0
db: UniProt

Reference/UniProt O81027
type: UnificationXref
id: O81027
db: UniProt

Glutamate decarboxylase 1
type: ProteinReference
xref: Reference/UniProt Q42521
organism: Arabidopsis thaliana