Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

O-Phosphoethanolamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000224
xref: Reference/BioCyc PHOSPHORYL-ETHANOLAMINE
xref: Reference/ChemSpider 990
xref: Reference/PubChem-compound 1015
xref: Reference/KEGG Compound C00346
xref: Reference/ChEBI CHEBI 17553
xref: Reference/CAS 1071-23-4
chemical formula: C2H8NO4P
molecular weight: 141.01909
structure: ChemicalStructure/PW C000149

Reference/BioCyc PHOSPHORYL-ETHANOLAMINE
type: UnificationXref
id: PHOSPHORYL-ETHANOLAMINE
db: BioCyc

Reference/TAXONOMY 3702
type: UnificationXref
id: 3702
db: TAXONOMY

Reference/KEGG Compound C02737
type: UnificationXref
id: C02737
db: KEGG Compound

Phosphorylcholine
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Phosphorylcholine

Reference/PubChem-compound 1014
type: UnificationXref
id: 1014
db: PubChem-compound

Reference/PubChem-compound 1015
type: UnificationXref
id: 1015
db: PubChem-compound

Choline-phosphate cytidylyltransferase A
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: Choline-phosphate cytidylyltransferase A

Phosphatidylcholine
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Phosphatidylcholine

Compound/PW C000096 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ethanolamine
stoichiometric coefficient: 1.0

Compound/PW C000170 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

S-Adenosylmethionine
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: S-Adenosylmethionine

Reference/HMDB HMDB0000095
type: UnificationXref
id: HMDB0000095
db: HMDB

Reference/ChEBI CHEBI 15958
type: UnificationXref
id: CHEBI:15958
db: ChEBI

Reference/HMDB HMDB0000097
type: UnificationXref
id: HMDB0000097
db: HMDB

Reference/HMDB HMDB0001185
type: UnificationXref
id: HMDB0001185
db: HMDB

Compound/PW C001202 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphorylcholine
stoichiometric coefficient: 1.0

Transport1201
type: Transport
participant stoichiometry: Compound/Generic74 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic74 Mitochondrial Outer Membrane/Stoichiometry/1.0
right: Phosphatidylcholine
spontaneous: true
left: Phosphatidylcholine
name: Phosphatidylcholine (↔) Transport: Homo sapiens, Cell, Endoplasmic Reticulum Membrane to Homo sapiens, Cell, Mitochondrial Outer Membrane
conversion direction: REVERSIBLE

Compound/Generic157 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: an L-1-Phosphatidylethanolamine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6131
type: UnificationXref
id: 6131
db: PubChem-compound

Reference/ChemSpider 13207
type: UnificationXref
id: 13207
db: ChemSpider

Ethanolamine
type: SmallMolecule
cellular location: Cytosol
entity reference: Ethanolamine

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

an L-1-Phosphatidylethanolamine
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: an L-1-Phosphatidylethanolamine

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Compound/PW C000921 Mitochondrial membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylmethionine
stoichiometric coefficient: 1.0

Compound/PW C000749 Mitochondrial membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylhomocysteine
stoichiometric coefficient: 1.0

Reference/BioCyc CDP-ETHANOLAMINE
type: UnificationXref
id: CDP-ETHANOLAMINE
db: BioCyc

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Reference/ChemSpider 110296
type: UnificationXref
id: 110296
db: ChemSpider

Compound/PW C000749 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylhomocysteine
stoichiometric coefficient: 1.0

Phosphatidylcholine Biosynthesis
type: Pathway
pathway order: PathwayEnzymeReaction/1193005
pathway order: PathwayEnzymeReaction/1193038
pathway order: PathwayEnzymeReaction/262621
pathway order: PathwayEnzymeReaction/262631
pathway order: PathwayEnzymeReaction/262642
pathway order: PathwayEnzymeReaction/1193024
pathway order: PathwayEnzymeReaction/1193040
pathway order: PathwayEnzymeReaction/262624
pathway order: PathwayEnzymeReaction/262629
pathway order: PathwayEnzymeReaction/467334
pathway order: PathwayTransport/1193031
pathway order: PathwayTransport/1193006
pathway order: PathwayTransport/1193037
pathway component: Transport1201
pathway component: ReactionCatalysis40027
pathway component: 2.7.1.82
pathway component: ReactionCatalysis40019
pathway component: 2.7.7.15
pathway component: ReactionCatalysis40025
pathway component: ReactionCatalysis40036
pathway component: ReactionCatalysis40015
pathway component: ReactionCatalysis40026
pathway component: ReactionCatalysis40037
pathway component: Transport1198
pathway component: 2.7.8.2
pathway component: Reaction49897
pathway component: 2.7.7.14
pathway component: 2.7.8.1
pathway component: 2.1.1.71
pathway component: 2.1.1.17
pathway component: Reaction49908
pathway component: Transport1193
pathway component: ReactionCatalysis40020
pathway component: ReactionCatalysis40022
pathway component: ReactionCatalysis40033
xref: Reference/PathWhiz PW015076
xref: Reference/SMPDB SMP0014212
organism: Homo sapiens

S-Adenosylmethionine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24762165
xref: Reference/KEGG Compound C00019
xref: Reference/ChemSpider 31983
xref: Reference/ChEBI CHEBI 15414
xref: Reference/CAS 485-80-3
xref: Reference/BioCyc S-ADENOSYLMETHIONINE
xref: Reference/HMDB HMDB0001185
chemical formula: C15H23N6O5S
molecular weight: 399.14505
structure: ChemicalStructure/PW C000921

ReactionCatalysis40036
type: Catalysis
controller: Choline/ethanolaminephosphotransferase 1
controlled: 2.7.8.1
control type: ACTIVATION

Reference/PubChem-compound 700
type: UnificationXref
id: 700
db: PubChem-compound

ReactionCatalysis40037
type: Catalysis
controller: Phosphatidylethanolamine N-methyltransferase
controlled: 2.1.1.17
control type: ACTIVATION

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/KEGG Compound C00570
type: UnificationXref
id: C00570
db: KEGG Compound

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

2.7.7.14
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000170 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000149 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000057 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001201 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: CDP-ethanolamine
right: Pyrophosphate
spontaneous: false
EC number: 2.7.7.14
left: O-Phosphoethanolamine
left: Cytidine triphosphate
name: Cytidine triphosphate + O-Phosphoethanolamine → CDP-ethanolamine + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

2.1.1.71
type: BiochemicalReaction
participant stoichiometry: Compound/Generic336 Mitochondrial membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921 Mitochondrial membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000749 Mitochondrial membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic14 Mitochondrial membrane/Stoichiometry/1.0
right: Phosphatidyl-N-dimethylethanolamine
right: S-Adenosylhomocysteine
spontaneous: false
EC number: 2.1.1.71
left: Phosphatidyl-N-methylethanolamine
left: S-Adenosylmethionine
name: Phosphatidyl-N-methylethanolamine + S-Adenosylmethionine → Phosphatidyl-N-dimethylethanolamine + S-Adenosylhomocysteine
conversion direction: LEFT_TO_RIGHT

Hydrogen Ion
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Hydrogen Ion

2.1.1.71
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000749 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic74 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic336 Mitochondrial Outer Membrane/Stoichiometry/1.0
right: S-Adenosylhomocysteine
right: Phosphatidylcholine
spontaneous: false
EC number: 2.1.1.71
left: S-Adenosylmethionine
left: Phosphatidyl-N-dimethylethanolamine
name: Phosphatidyl-N-dimethylethanolamine + S-Adenosylmethionine → Phosphatidylcholine + S-Adenosylhomocysteine
conversion direction: LEFT_TO_RIGHT

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reaction49908
type: BiochemicalReaction
participant stoichiometry: Compound/Generic157 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic159 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Mitochondrial Inner Membrane/Stoichiometry/1.0
right: Carbon dioxide
right: an L-1-Phosphatidylethanolamine
spontaneous: false
left: an L-1-Phosphatidylserine
name: an L-1-Phosphatidylserine → Carbon dioxide + an L-1-Phosphatidylethanolamine
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Phosphatidyl-N-methylethanolamine
type: SmallMolecule
cellular location: Mitochondrial membrane
entity reference: Phosphatidyl-N-methylethanolamine

Cytidine monophosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Cytidine monophosphate

O-Phosphoethanolamine
type: SmallMolecule
cellular location: Cytosol
entity reference: O-Phosphoethanolamine

Reference/BioCyc ADENOSYL-HOMO-CYS
type: UnificationXref
id: ADENOSYL-HOMO-CYS
db: BioCyc

Reference/ChEBI CHEBI 64482
type: UnificationXref
id: CHEBI:64482
db: ChEBI

Reference/CAS 485-80-3
type: UnificationXref
id: 485-80-3
db: CAS

Reference/KEGG Compound C00588
type: UnificationXref
id: C00588
db: KEGG Compound

Reference/KEGG Compound C00346
type: UnificationXref
id: C00346
db: KEGG Compound

2.7.8.1
type: BiochemicalReaction
participant stoichiometry: Compound/Generic157 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic295 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001201 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000064 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: an L-1-Phosphatidylethanolamine
right: Cytidine monophosphate
spontaneous: false
EC number: 2.7.8.1
left: CDP-ethanolamine
left: 1,2-Diacyl-sn-glycerol
name: 1,2-Diacyl-sn-glycerol + CDP-ethanolamine → Cytidine monophosphate + an L-1-Phosphatidylethanolamine
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 16000
type: UnificationXref
id: CHEBI:16000
db: ChEBI

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

2.1.1.17
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000921 Mitochondrial membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000749 Mitochondrial membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic14 Mitochondrial membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic157 Mitochondrial membrane/Stoichiometry/1.0
right: S-Adenosylhomocysteine
right: Phosphatidyl-N-methylethanolamine
spontaneous: false
EC number: 2.1.1.17
left: S-Adenosylmethionine
left: an L-1-Phosphatidylethanolamine
name: S-Adenosylmethionine + an L-1-Phosphatidylethanolamine → Phosphatidyl-N-methylethanolamine + S-Adenosylhomocysteine
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0001413
type: UnificationXref
id: HMDB0001413
db: HMDB

Compound/Generic159 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: an L-1-Phosphatidylserine
stoichiometric coefficient: 1.0

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

S-Adenosylhomocysteine
type: SmallMolecule
cellular location: Mitochondrial membrane
entity reference: S-Adenosylhomocysteine

Pyrophosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Pyrophosphate

Reference/CAS 63-37-6
type: UnificationXref
id: 63-37-6
db: CAS

Mitochondrial membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0031966

Reference/ChEBI CHEBI 16732
type: UnificationXref
id: CHEBI:16732
db: ChEBI

ReactionCatalysis40019
type: Catalysis
controller: Choline-phosphate cytidylyltransferase A
controlled: 2.7.7.15
control type: ACTIVATION

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

ReactionCatalysis40015
type: Catalysis
controller: Choline kinase alpha
controlled: 2.7.1.82
control type: ACTIVATION

ChemicalStructure/PW C000921
type: ChemicalStructure
structure format: SMILES

Reference/CAS 979-92-0
type: UnificationXref
id: 979-92-0
db: CAS

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/KEGG Compound C00350
type: UnificationXref
id: C00350
db: KEGG Compound

Reference/SMPDB SMP0014212
type: UnificationXref
id: SMP0014212
db: SMPDB

Reference/KEGG Compound C00114
type: UnificationXref
id: C00114
db: KEGG Compound

Reference/CAS 1071-23-4
type: UnificationXref
id: 1071-23-4
db: CAS

S-Adenosylhomocysteine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 25246222
xref: Reference/ChemSpider 388301
xref: Reference/BioCyc ADENOSYL-HOMO-CYS
xref: Reference/CAS 979-92-0
xref: Reference/KEGG Compound C00021
xref: Reference/ChEBI CHEBI 16680
xref: Reference/HMDB HMDB0000939
chemical formula: C14H20N6O5S
molecular weight: 384.12158
structure: ChemicalStructure/PW C000749

ReactionCatalysis40020
type: Catalysis
controller: Choline/ethanolaminephosphotransferase 1
controlled: 2.7.8.2
control type: ACTIVATION

CDP-Choline
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: CDP-Choline

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

ReactionCatalysis40022
type: Catalysis
controller: Choline kinase alpha
controlled: Reaction49897
control type: ACTIVATION

1,2-Diacyl-sn-glycerol
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00641

an L-1-Phosphatidylserine
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: an L-1-Phosphatidylserine

ReactionCatalysis40027
type: Catalysis
controller: Phosphatidylethanolamine N-methyltransferase
controlled: 2.1.1.71
control type: ACTIVATION

Reference/BioCyc CDP-CHOLINE
type: UnificationXref
id: CDP-CHOLINE
db: BioCyc

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Choline
type: SmallMolecule
cellular location: Cytosol
entity reference: Choline

Reference/ChEBI CHEBI 15414
type: UnificationXref
id: CHEBI:15414
db: ChEBI

ReactionCatalysis40025
type: Catalysis
controller: Ethanolamine-phosphate cytidylyltransferase
controlled: 2.7.7.14
control type: ACTIVATION

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

ReactionCatalysis40026
type: Catalysis
controller: Phosphatidylethanolamine N-methyltransferase
controlled: 2.1.1.71
control type: ACTIVATION

Reference/BioCyc CTP
type: UnificationXref
id: CTP
db: BioCyc

Compound/PW C000921 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylmethionine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/HMDB HMDB0000224
type: UnificationXref
id: HMDB0000224
db: HMDB

Reference/ChemSpider 13835336
type: UnificationXref
id: 13835336
db: ChemSpider

Mitochondrial Inner Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005743

ChemicalStructure/PW C043034
type: ChemicalStructure
structure format: SMILES

ReactionCatalysis40033
type: Catalysis
controller: Phosphatidylserine decarboxylase proenzyme
controlled: Reaction49908
control type: ACTIVATION

Reference/KEGG Compound C00019
type: UnificationXref
id: C00019
db: KEGG Compound

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17361
type: UnificationXref
id: CHEBI:17361
db: ChEBI

Compound/PW C001201 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: CDP-ethanolamine
stoichiometric coefficient: 1.0

Reference/BioCyc S-ADENOSYLMETHIONINE
type: UnificationXref
id: S-ADENOSYLMETHIONINE
db: BioCyc

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

BiologicalState249
type: BioSource
xref: Reference/TAXONOMY 3702
name: Arabidopsis thaliana

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Reference/HMDB HMDB0001564
type: UnificationXref
id: HMDB0001564
db: HMDB

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

Reference/HMDB HMDB0001565
type: UnificationXref
id: HMDB0001565
db: HMDB

ChemicalStructure/PW C001202
type: ChemicalStructure
structure format: SMILES
structure data: C[N+](C)(C)CCOP(O)(O)=O

Compound/PW C000057 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cytidine triphosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001201
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/GENE ONTOLOGY GO 0005743
type: UnificationXref
id: GO:0005743
db: GENE ONTOLOGY

Cytidine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17677
xref: Reference/CAS 65-47-4
xref: Reference/PubChem-compound 6176
xref: Reference/KEGG Compound C00063
xref: Reference/ChemSpider 5941
xref: Reference/HMDB HMDB0000082
xref: Reference/BioCyc CTP
chemical formula: C9H16N3O14P3
molecular weight: 482.9845
structure: ChemicalStructure/PW C000057

Reference/GENE ONTOLOGY GO 0005741
type: UnificationXref
id: GO:0005741
db: GENE ONTOLOGY

Pyrophosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Pyrophosphate

Reference/UniProt P35790
type: UnificationXref
id: P35790
db: UniProt

Phosphatidylethanolamine N-methyltransferase
type: Protein
cellular location: Mitochondrial membrane
entity reference: Phosphatidylethanolamine N-methyltransferase

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/ChemSpider 388301
type: UnificationXref
id: 388301
db: ChemSpider

Reference/BioCyc CPD-563
type: UnificationXref
id: CPD-563
db: BioCyc

an L-1-Phosphatidylethanolamine
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: an L-1-Phosphatidylethanolamine

Phosphatidylcholine
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Phosphatidylcholine

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/KEGG Compound C00021
type: UnificationXref
id: C00021
db: KEGG Compound

Phosphatidylcholine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 64482

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Cytidine triphosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Cytidine triphosphate

Compound/PW C000065 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Choline
stoichiometric coefficient: 1.0

Reference/BioCyc PHOSPHORYL-CHOLINE
type: UnificationXref
id: PHOSPHORYL-CHOLINE
db: BioCyc

Choline
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15354
xref: Reference/ChemSpider 299
xref: Reference/BioCyc CPD-563
xref: Reference/PubChem-compound 305
xref: Reference/CAS 62-49-7
xref: Reference/HMDB HMDB0000097
xref: Reference/KEGG Compound C00114
chemical formula: C5H14NO
molecular weight: 104.10754
structure: ChemicalStructure/PW C000065

Cytidine monophosphate
type: SmallMoleculeReference
xref: Reference/BioCyc CMP
xref: Reference/ChemSpider 5901
xref: Reference/PubChem-compound 6131
xref: Reference/ChEBI CHEBI 17361
xref: Reference/KEGG Compound C00055
xref: Reference/HMDB HMDB0000095
xref: Reference/CAS 63-37-6
chemical formula: C9H14N3O8P
molecular weight: 323.05185
structure: ChemicalStructure/PW C000064

an L-1-Phosphatidylethanolamine
type: SmallMolecule
cellular location: Mitochondrial membrane
entity reference: an L-1-Phosphatidylethanolamine

Carbon dioxide
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: Carbon dioxide

Mitochondrial Outer Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005741

Endoplasmic Reticulum
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005783

S-Adenosylhomocysteine
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: S-Adenosylhomocysteine

Endoplasmic Reticulum Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005789

Compound/PW C000064 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cytidine monophosphate
stoichiometric coefficient: 1.0

Reference/UniProt P49585
type: UnificationXref
id: P49585
db: UniProt

Choline kinase alpha
type: Protein
cellular location: Cytosol
entity reference: Choline kinase alpha

ChemicalStructure/PW C000057
type: ChemicalStructure
structure format: SMILES

Reference/UniProt Q9Y6K0
type: UnificationXref
id: Q9Y6K0
db: UniProt

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Phosphatidylethanolamine N-methyltransferase
type: ProteinReference
xref: Reference/UniProt Q9UBM1
organism: Homo sapiens

2.7.1.82
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000096 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000149 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: Hydrogen Ion
right: O-Phosphoethanolamine
spontaneous: false
EC number: 2.7.1.82
left: Ethanolamine
left: Adenosine triphosphate
name: Adenosine triphosphate + Ethanolamine → Adenosine diphosphate + Hydrogen Ion + O-Phosphoethanolamine
conversion direction: LEFT_TO_RIGHT

Compound/Generic157 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: an L-1-Phosphatidylethanolamine
stoichiometric coefficient: 1.0

2.7.7.15
type: BiochemicalReaction
participant stoichiometry: Compound/PW C043034 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000057 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001202 Endoplasmic Reticulum/Stoichiometry/1.0
right: CDP-Choline
right: Pyrophosphate
spontaneous: false
EC number: 2.7.7.15
left: Phosphorylcholine
left: Cytidine triphosphate
name: Cytidine triphosphate + Phosphorylcholine → CDP-Choline + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

2.7.8.2
type: BiochemicalReaction
participant stoichiometry: Compound/Generic74 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic295 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C043034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000064 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Phosphatidylcholine
right: Cytidine monophosphate
right: Hydrogen Ion
spontaneous: false
EC number: 2.7.8.2
left: 1,2-Diacyl-sn-glycerol
left: CDP-Choline
name: 1,2-Diacyl-sn-glycerol + CDP-Choline → Cytidine monophosphate + Hydrogen Ion + Phosphatidylcholine
conversion direction: LEFT_TO_RIGHT

Reaction49897
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001202 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: Phosphorylcholine
spontaneous: false
left: Adenosine triphosphate
left: Choline
name: Adenosine triphosphate + Choline → Adenosine diphosphate + Phosphorylcholine
conversion direction: LEFT_TO_RIGHT

Phosphorylcholine
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphorylcholine

Reference/HMDB HMDB0000939
type: UnificationXref
id: HMDB0000939
db: HMDB

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000065
type: ChemicalStructure
structure format: SMILES
structure data: C[N+](C)(C)CCO

ChemicalStructure/PW C000064
type: ChemicalStructure
structure format: SMILES

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine diphosphate

Reference/HMDB HMDB0000149
type: UnificationXref
id: HMDB0000149
db: HMDB

Compound/Generic336 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidyl-N-dimethylethanolamine
stoichiometric coefficient: 1.0

Compound/PW C000149 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: O-Phosphoethanolamine
stoichiometric coefficient: 1.0

Reference/ChemSpider 5901
type: UnificationXref
id: 5901
db: ChemSpider

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/UniProt Q9UG56
type: UnificationXref
id: Q9UG56
db: UniProt

an L-1-Phosphatidylserine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C02737

Reference/PubChem-compound 305
type: UnificationXref
id: 305
db: PubChem-compound

Transport1198
type: Transport
participant stoichiometry: Compound/Generic157 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic157 Mitochondrial Outer Membrane/Stoichiometry/1.0
right: an L-1-Phosphatidylethanolamine
spontaneous: false
left: an L-1-Phosphatidylethanolamine
name: an L-1-Phosphatidylethanolamine (←) Transport: Homo sapiens, Cell, Mitochondrial Inner Membrane to Homo sapiens, Cell, Mitochondrial Outer Membrane
conversion direction: LEFT_TO_RIGHT

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Reference/ChEBI CHEBI 18132
type: UnificationXref
id: CHEBI:18132
db: ChEBI

Reference/KEGG Compound C00055
type: UnificationXref
id: C00055
db: KEGG Compound

ChemicalStructure/PW C000149
type: ChemicalStructure
structure format: SMILES
structure data: NCCOP(O)(O)=O

Compound/PW C001034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Cytidine triphosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Cytidine triphosphate

Compound/Generic157 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: an L-1-Phosphatidylethanolamine
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00063
type: UnificationXref
id: C00063
db: KEGG Compound

Reference/GENE ONTOLOGY GO 0005789
type: UnificationXref
id: GO:0005789
db: GENE ONTOLOGY

Reference/BioCyc ETHANOL-AMINE
type: UnificationXref
id: ETHANOL-AMINE
db: BioCyc

an L-1-Phosphatidylethanolamine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00350

Reference/GENE ONTOLOGY GO 0005783
type: UnificationXref
id: GO:0005783
db: GENE ONTOLOGY

Compound/PW C001202 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphorylcholine
stoichiometric coefficient: 1.0

Ethanolamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000149
xref: Reference/ChemSpider 13835336
xref: Reference/PubChem-compound 700
xref: Reference/CAS 141-43-5
xref: Reference/BioCyc ETHANOL-AMINE
xref: Reference/ChEBI CHEBI 16000
xref: Reference/KEGG Compound C00189
chemical formula: C2H7NO
molecular weight: 61.052765
structure: ChemicalStructure/PW C000096

Compound/Generic74 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylcholine
stoichiometric coefficient: 1.0

O-Phosphoethanolamine
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: O-Phosphoethanolamine

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/KEGG Compound C04308
type: UnificationXref
id: C04308
db: KEGG Compound

Phosphatidyl-N-dimethylethanolamine
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Phosphatidyl-N-dimethylethanolamine

CDP-Choline
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: CDP-Choline

Ethanolamine-phosphate cytidylyltransferase
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Ethanolamine-phosphate cytidylyltransferase

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Phosphatidylethanolamine N-methyltransferase
type: Protein
cellular location: Mitochondrial Outer Membrane
entity reference: Phosphatidylethanolamine N-methyltransferase

an L-1-Phosphatidylethanolamine
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: an L-1-Phosphatidylethanolamine

Compound/PW C000057 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cytidine triphosphate
stoichiometric coefficient: 1.0

Reference/UniProt Q9UBM1
type: UnificationXref
id: Q9UBM1
db: UniProt

Phosphatidylserine decarboxylase proenzyme
type: ProteinReference
xref: Reference/UniProt Q9UG56
organism: Homo sapiens

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Reference/KEGG Compound C00189
type: UnificationXref
id: C00189
db: KEGG Compound

Reference/CAS 107-73-3
type: UnificationXref
id: 107-73-3
db: CAS

Reference/CAS 65-47-4
type: UnificationXref
id: 65-47-4
db: CAS

Ethanolamine-phosphate cytidylyltransferase
type: ProteinReference
xref: Reference/UniProt Q99447
organism: Homo sapiens

Reference/UniProt Q99447
type: UnificationXref
id: Q99447
db: UniProt

Reference/CAS 3036-18-8
type: UnificationXref
id: 3036-18-8
db: CAS

Choline/ethanolaminephosphotransferase 1
type: ProteinReference
xref: Reference/UniProt Q9Y6K0
organism: Homo sapiens

CDP-ethanolamine
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: CDP-ethanolamine

Reference/PathWhiz PW015076
type: UnificationXref
id: PW015076
db: PathWhiz

Reference/CAS 987-78-0
type: UnificationXref
id: 987-78-0
db: CAS

Choline kinase alpha
type: ProteinReference
xref: Reference/UniProt P35790
organism: Homo sapiens

Transport1193
type: Transport
participant stoichiometry: Compound/Generic157 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic157 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: an L-1-Phosphatidylethanolamine
spontaneous: false
left: an L-1-Phosphatidylethanolamine
name: an L-1-Phosphatidylethanolamine (→) Transport: Homo sapiens, Cell, Endoplasmic Reticulum Membrane to Homo sapiens, Cell, Mitochondrial Outer Membrane
conversion direction: LEFT_TO_RIGHT

Choline-phosphate cytidylyltransferase A
type: ProteinReference
xref: Reference/UniProt P49585
organism: BiologicalState249

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/ChemSpider 31983
type: UnificationXref
id: 31983
db: ChemSpider

Phosphatidyl-N-dimethylethanolamine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C04308

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Choline/ethanolaminephosphotransferase 1
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Choline/ethanolaminephosphotransferase 1

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Compound/PW C040034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/BioCyc CMP
type: UnificationXref
id: CMP
db: BioCyc

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Compound/PW C000149 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: O-Phosphoethanolamine
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000096
type: ChemicalStructure
structure format: SMILES
structure data: NCCO

Reference/ChemSpider 299
type: UnificationXref
id: 299
db: ChemSpider

Compound/Generic74 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylcholine
stoichiometric coefficient: 1.0

CDP-ethanolamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001564
xref: Reference/ChEBI CHEBI 16732
xref: Reference/PubChem-compound 123727
xref: Reference/CAS 3036-18-8
xref: Reference/BioCyc CDP-ETHANOLAMINE
xref: Reference/KEGG Compound C00570
xref: Reference/ChemSpider 110296
chemical formula: C11H20N4O11P2
molecular weight: 446.0604
structure: ChemicalStructure/PW C001201

Phosphorylcholine
type: SmallMoleculeReference
xref: Reference/CAS 107-73-3
xref: Reference/HMDB HMDB0001565
xref: Reference/BioCyc PHOSPHORYL-CHOLINE
xref: Reference/PubChem-compound 1014
xref: Reference/ChEBI CHEBI 18132
xref: Reference/KEGG Compound C00588
xref: Reference/ChemSpider 989
chemical formula: C5H15NO4P
molecular weight: 184.07387
structure: ChemicalStructure/PW C001202

Compound/Generic295 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1,2-Diacyl-sn-glycerol
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17677
type: UnificationXref
id: CHEBI:17677
db: ChEBI

Phosphatidyl-N-dimethylethanolamine
type: SmallMolecule
cellular location: Mitochondrial membrane
entity reference: Phosphatidyl-N-dimethylethanolamine

Reference/PubChem-compound 6176
type: UnificationXref
id: 6176
db: PubChem-compound

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

Compound/PW C000170 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Phosphatidyl-N-methylethanolamine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15958

Reference/ChEBI CHEBI 17553
type: UnificationXref
id: CHEBI:17553
db: ChEBI

Reference/KEGG Compound C00641
type: UnificationXref
id: C00641
db: KEGG Compound

Reference/PubChem-compound 123727
type: UnificationXref
id: 123727
db: PubChem-compound

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Reference/PubChem-compound 11583971
type: UnificationXref
id: 11583971
db: PubChem-compound

1,2-Diacyl-sn-glycerol
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: 1,2-Diacyl-sn-glycerol

Compound/PW C043034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: CDP-Choline
stoichiometric coefficient: 1.0

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Reference/ChemSpider 5941
type: UnificationXref
id: 5941
db: ChemSpider

Reference/ChEBI CHEBI 16436
type: UnificationXref
id: CHEBI:16436
db: ChEBI

ChemicalStructure/PW C000749
type: ChemicalStructure
structure format: SMILES

Compound/PW C001316 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Compound/Generic157 Mitochondrial membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: an L-1-Phosphatidylethanolamine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 25246222
type: UnificationXref
id: 25246222
db: PubChem-compound

Reference/ChemSpider 990
type: UnificationXref
id: 990
db: ChemSpider

Reference/GENE ONTOLOGY GO 0031966
type: UnificationXref
id: GO:0031966
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 15354
type: UnificationXref
id: CHEBI:15354
db: ChEBI

Compound/PW C043034 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: CDP-Choline
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Reference/KEGG Compound C00307
type: UnificationXref
id: C00307
db: KEGG Compound

Reference/CAS 141-43-5
type: UnificationXref
id: 141-43-5
db: CAS

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/ChEBI CHEBI 16680
type: UnificationXref
id: CHEBI:16680
db: ChEBI

Phosphatidylserine decarboxylase proenzyme
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Phosphatidylserine decarboxylase proenzyme

Reference/CAS 62-49-7
type: UnificationXref
id: 62-49-7
db: CAS

Reference/ChemSpider 989
type: UnificationXref
id: 989
db: ChemSpider

S-Adenosylmethionine
type: SmallMolecule
cellular location: Mitochondrial membrane
entity reference: S-Adenosylmethionine

Reference/PubChem-compound 24762165
type: UnificationXref
id: 24762165
db: PubChem-compound

Compound/Generic336 Mitochondrial membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidyl-N-dimethylethanolamine
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000082
type: UnificationXref
id: HMDB0000082
db: HMDB

Compound/Generic14 Mitochondrial membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidyl-N-methylethanolamine
stoichiometric coefficient: 1.0

CDP-Choline
type: SmallMoleculeReference
xref: Reference/BioCyc CDP-CHOLINE
xref: Reference/ChemSpider 13207
xref: Reference/HMDB HMDB0001413
xref: Reference/ChEBI CHEBI 16436
xref: Reference/KEGG Compound C00307
xref: Reference/PubChem-compound 11583971
xref: Reference/CAS 987-78-0
chemical formula: C14H26N4O11P2
molecular weight: 488.10733
structure: ChemicalStructure/PW C043034