Reference/ChEBI CHEBI 50608
type: UnificationXref
id: CHEBI:50608
db: ChEBI

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/TAXONOMY 3702
type: UnificationXref
id: 3702
db: TAXONOMY

Compound/PW C000170 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/ChEBI CHEBI 59546
type: UnificationXref
id: CHEBI:59546
db: ChEBI

Reference/ChEBI CHEBI 16134
type: UnificationXref
id: CHEBI:16134
db: ChEBI

Reference/ChemSpider 431981
type: UnificationXref
id: 431981
db: ChemSpider

4.1.99.12
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000479 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042618 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000092 Chloroplast/Stoichiometry/1.0
right: L-3,4-Dihydroxybutan-2-one 4-phosphate
right: Formic acid
spontaneous: false
EC number: 4.1.99.12
left: D-Ribulose 5-phosphate
name: D-Ribulose 5-phosphate → Formic acid + L-3,4-Dihydroxybutan-2-one 4-phosphate
conversion direction: LEFT_TO_RIGHT

4.1.99.12
type: BiochemicalReaction
participant stoichiometry: Compound/PW C096932 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Chloroplast/Stoichiometry/3.0
participant stoichiometry: Compound/PW C000986 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000092 Chloroplast/Stoichiometry/1.0
right: Formic acid
right: Pyrophosphate
right: 2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
spontaneous: false
EC number: 4.1.99.12
left: Water
left: Guanosine triphosphate
name: Guanosine triphosphate + 3 Water → 2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + Formic acid + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

3.5.4.26
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C096932 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041187 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Chloroplast/Stoichiometry/1.0
right: 5-Amino-6-(5'-phosphoribosylamino)uracil
right: Ammonia
spontaneous: false
EC number: 3.5.4.26
left: Water
left: 2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
name: 2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + Water → 5-Amino-6-(5'-phosphoribosylamino)uracil + Ammonia
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

1.1.1.193
type: BiochemicalReaction
participant stoichiometry: Compound/PW C096927 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041187 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Chloroplast/Stoichiometry/1.0
right: 5-Amino-6-(5'-phosphoribosylamino)uracil
right: Hydrogen Ion
right: NADPH
spontaneous: false
EC number: 1.1.1.193
left: 5-Amino-6-(5'-phospho-D-ribitylamino)uracil
left: NADP
name: 5-Amino-6-(5'-phospho-D-ribitylamino)uracil + NADP ← 5-Amino-6-(5'-phosphoribosylamino)uracil + Hydrogen Ion + NADPH
conversion direction: RIGHT_TO_LEFT

Ammonia
type: SmallMoleculeReference
xref: Reference/BioCyc AMMONIA
xref: Reference/CAS 7664-41-7
xref: Reference/HMDB HMDB0000051
xref: Reference/PubChem-compound 222
xref: Reference/KEGG Compound C00014
xref: Reference/ChEBI CHEBI 16134
xref: Reference/ChemSpider 217
chemical formula: H3N
molecular weight: 17.026548
structure: ChemicalStructure/PW C000035

Pyrophosphate
type: SmallMolecule
cellular location: Chloroplast
entity reference: Pyrophosphate

Reference/CAS 17014-74-3
type: UnificationXref
id: 17014-74-3
db: CAS

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

Reference/PubChem-compound 93581524
type: UnificationXref
id: 93581524
db: PubChem-compound

Hydrogen Ion
type: SmallMolecule
cellular location: Chloroplast
entity reference: Hydrogen Ion

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

Riboflavin
type: SmallMolecule
cellular location: Chloroplast
entity reference: Riboflavin

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

3.1.3.102,3.1.3.104
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001170 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000165 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Chloroplast/Stoichiometry/1.0
right: Phosphate
right: Riboflavin
spontaneous: false
EC number: 3.1.3.102,3.1.3.104
left: Water
left: Flavin Mononucleotide
name: Flavin Mononucleotide + Water → Phosphate + Riboflavin
conversion direction: LEFT_TO_RIGHT

2.5.1.78
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001973 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Chloroplast/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001104 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042618 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C096928 Chloroplast/Stoichiometry/1.0
right: Phosphate
right: Water
right: 6,7-Dimethyl-8-(1-D-ribityl)lumazine
spontaneous: false
EC number: 2.5.1.78
left: L-3,4-Dihydroxybutan-2-one 4-phosphate
left: 5-Amino-6-(D-ribitylamino)uracil
name: 5-Amino-6-(D-ribitylamino)uracil + L-3,4-Dihydroxybutan-2-one 4-phosphate → 6,7-Dimethyl-8-(1-D-ribityl)lumazine + Phosphate + 2 Water
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Compound/PW C000092 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: Formic acid
stoichiometric coefficient: 1.0

Compound/PW C040034 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Phosphate
type: SmallMolecule
cellular location: Chloroplast
entity reference: Phosphate

Reference/UniProt Q6NLQ7
type: UnificationXref
id: Q6NLQ7
db: UniProt

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Riboflavin
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000244
xref: Reference/BioCyc RIBOFLAVIN
xref: Reference/ChemSpider 431981
xref: Reference/ChEBI CHEBI 17015
xref: Reference/CAS 83-88-5
xref: Reference/PubChem-compound 493570
xref: Reference/KEGG Compound C00255
chemical formula: C17H20N4O6
molecular weight: 376.13828
structure: ChemicalStructure/PW C000165

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
type: SmallMolecule
cellular location: Chloroplast
entity reference: 2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one

Reference/UniProt Q84VZ1
type: UnificationXref
id: Q84VZ1
db: UniProt

Reference/ChemSpider 18921533
type: UnificationXref
id: 18921533
db: ChemSpider

ChemicalStructure/PW C096927
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C096928
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C01304
type: UnificationXref
id: C01304
db: KEGG Compound

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Reference/ChEBI CHEBI 16238
type: UnificationXref
id: CHEBI:16238
db: ChEBI

Compound/PW C041187 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Amino-6-(5'-phosphoribosylamino)uracil
stoichiometric coefficient: 1.0

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/PubChem-compound 439184
type: UnificationXref
id: 439184
db: PubChem-compound

Compound/PW C000414 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/HMDB HMDB0001520
type: UnificationXref
id: HMDB0001520
db: HMDB

Reference/BioCyc FMN
type: UnificationXref
id: FMN
db: BioCyc

Reference/ChemSpider 278
type: UnificationXref
id: 278
db: ChemSpider

Reference/GENE ONTOLOGY GO 0009507
type: UnificationXref
id: GO:0009507
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 15934
type: UnificationXref
id: CHEBI:15934
db: ChEBI

Compound/PW C096928 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Amino-6-(D-ribitylamino)uracil
stoichiometric coefficient: 1.0

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

ReactionCatalysis98509
type: Catalysis
controller: Flavin mononucleotide hydrolase 1, chloroplatic
controlled: 3.1.3.102,3.1.3.104
control type: ACTIVATION

ReactionCatalysis98507
type: Catalysis
controller: Riboflavin biosynthesis protein PYRD, chloroplastic
controlled: 3.5.4.26
control type: ACTIVATION

ReactionCatalysis98508
type: Catalysis
controller: Riboflavin biosynthesis protein PYRR, chloroplastic
controlled: 1.1.1.193
control type: ACTIVATION

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: O4P
molecular weight: 94.95342
structure: ChemicalStructure/PW C001104

ReactionCatalysis98505
type: Catalysis
controller: Monofunctional riboflavin biosynthesis protein RIBA 2, chloroplastic
controlled: 4.1.99.12
control type: ACTIVATION

ReactionCatalysis98506
type: Catalysis
controller: Monofunctional riboflavin biosynthesis protein RIBA 2, chloroplastic
controlled: 4.1.99.12
control type: ACTIVATION

ChemicalStructure/PW C096932
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0003826
type: UnificationXref
id: HMDB0003826
db: HMDB

Reference/PubChem-compound 6830
type: UnificationXref
id: 6830
db: PubChem-compound

Compound/PW C000035 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonia
stoichiometric coefficient: 1.0

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H29N7O17P3
molecular weight: 744.08325
structure: ChemicalStructure/PW C000143

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

6,7-dimethyl-8-ribityllumazine synthase, chloroplastic
type: Protein
cellular location: Chloroplast
entity reference: 6,7-dimethyl-8-ribityllumazine synthase, chloroplastic

Bifunctional riboflavin kinase/FMN phosphatase
type: Protein
cellular location: Chloroplast
entity reference: Bifunctional riboflavin kinase/FMN phosphatase

Guanosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15996
xref: Reference/ChemSpider 6569
xref: Reference/KEGG Compound C00044
xref: Reference/PubChem-compound 6830
xref: Reference/HMDB HMDB0001273
xref: Reference/CAS 86-01-1
xref: Reference/BioCyc GTP
chemical formula: C10H16N5O14P3
molecular weight: 522.99066
structure: ChemicalStructure/PW C000986

Compound/PW C001034 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Adenosine monophosphate
type: SmallMolecule
cellular location: Chloroplast
entity reference: Adenosine monophosphate

ReactionCatalysis98516
type: Catalysis
controller: Flavin mononucleotide hydrolase 1, chloroplatic
controlled: 3.1.3.104
control type: ACTIVATION

ReactionCatalysis98515
type: Catalysis
controller: Nudix hydrolase 23, chloroplastic
controlled: 3.6.1.18
control type: ACTIVATION

ReactionCatalysis98512
type: Catalysis
controller: Bifunctional riboflavin kinase/FMN phosphatase
controlled: 3.1.3.102,2.7.1.26
control type: ACTIVATION

Reference/ChemSpider 217
type: UnificationXref
id: 217
db: ChemSpider

ReactionCatalysis98510
type: Catalysis
controller: 6,7-dimethyl-8-ribityllumazine synthase, chloroplastic
controlled: 2.5.1.78
control type: ACTIVATION

ReactionCatalysis98511
type: Catalysis
controller: riboflavin synthase
controlled: Reaction108400
control type: ACTIVATION

Reference/UniProt Q84MD8
type: UnificationXref
id: Q84MD8
db: UniProt

Reference/UniProt Q8GWP5
type: UnificationXref
id: Q8GWP5
db: UniProt

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])([O-])=O

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/CAS 5118-16-1
type: UnificationXref
id: 5118-16-1
db: CAS

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/ChEBI CHEBI 18247
type: UnificationXref
id: CHEBI:18247
db: ChEBI

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/ChemSpider 559059
type: UnificationXref
id: 559059
db: ChemSpider

NADP
type: SmallMolecule
cellular location: Chloroplast
entity reference: NADP

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/PubChem-compound 672
type: UnificationXref
id: 672
db: PubChem-compound

Reference/PubChem-compound 493570
type: UnificationXref
id: 493570
db: PubChem-compound

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

ChemicalStructure/PW C042618
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)[C@@H](O)COP(O)(O)=O

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Reference/ChemSpider 559060
type: UnificationXref
id: 559060
db: ChemSpider

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Compound/PW C000479 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Ribulose 5-phosphate
stoichiometric coefficient: 1.0

Compound/PW C001420 Chloroplast/Stoichiometry/3.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 3.0

Reference/CAS 7664-41-7
type: UnificationXref
id: 7664-41-7
db: CAS

Flavin Mononucleotide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001520
xref: Reference/BioCyc FMN
xref: Reference/ChemSpider 559060
xref: Reference/CAS 146-17-8
xref: Reference/ChEBI CHEBI 17621
xref: Reference/PubChem-compound 643976
xref: Reference/KEGG Compound C00061
chemical formula: C17H21N4O9P
molecular weight: 456.1046
structure: ChemicalStructure/PW C001170

Reference/ChEBI CHEBI 18337
type: UnificationXref
id: CHEBI:18337
db: ChEBI

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Riboflavin Metabolism
type: Pathway
pathway order: PathwayEnzymeReaction/1187086
pathway order: PathwayEnzymeReaction/1187087
pathway order: PathwayEnzymeReaction/1187088
pathway order: PathwayEnzymeReaction/1187089
pathway order: PathwayEnzymeReaction/1187090
pathway order: PathwaySubPathway/57028
pathway order: PathwayEnzymeReaction/1187091
pathway order: PathwaySubPathway/57027
pathway order: PathwayEnzymeReaction/1187092
pathway order: PathwayEnzymeReaction/1187093
pathway order: PathwayEnzymeReaction/1187083
pathway order: PathwayEnzymeReaction/1187084
pathway component: Pentose phosphate pathway
pathway component: ReactionCatalysis98509
pathway component: Purine metabolism
pathway component: ReactionCatalysis98507
pathway component: ReactionCatalysis98508
pathway component: ReactionCatalysis98516
pathway component: 3.1.3.102,3.1.3.104
pathway component: ReactionCatalysis98505
pathway component: ReactionCatalysis98506
pathway component: 2.5.1.78
pathway component: Reaction108400
pathway component: 3.1.3.102,2.7.1.26
pathway component: ReactionCatalysis98515
pathway component: ReactionCatalysis98512
pathway component: ReactionCatalysis98510
pathway component: 3.6.1.18
pathway component: 3.1.3.104
pathway component: ReactionCatalysis98511
pathway component: 4.1.99.12
pathway component: 3.5.4.26
pathway component: 1.1.1.193
xref: Reference/SMPDB SMP0063462
xref: Reference/PathWhiz PW064424
organism: Arabidopsis thaliana

FAD
type: SmallMoleculeReference
xref: Reference/CAS 146-14-5
xref: Reference/HMDB HMDB0001248
xref: Reference/ChEBI CHEBI 16238
xref: Reference/BioCyc FAD
xref: Reference/PubChem-compound 643975
xref: Reference/ChemSpider 559059
xref: Reference/KEGG Compound C00016
chemical formula: C27H33N9O15P2
molecular weight: 785.1571
structure: ChemicalStructure/PW C000964

Reference/KEGG Compound C04732
type: UnificationXref
id: C04732
db: KEGG Compound

Reference/BioCyc AMINO-RIBOSYLAMINO-1H-3H-PYR-DIONE
type: UnificationXref
id: AMINO-RIBOSYLAMINO-1H-3H-PYR-DIONE
db: BioCyc

Reference/KEGG Compound C00016
type: UnificationXref
id: C00016
db: KEGG Compound

Reference/PubChem-compound 222
type: UnificationXref
id: 222
db: PubChem-compound

Reference/KEGG Compound C00014
type: UnificationXref
id: C00014
db: KEGG Compound

Reference/ChEBI CHEBI 17363
type: UnificationXref
id: CHEBI:17363
db: ChEBI

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Reference/KEGG Compound C00255
type: UnificationXref
id: C00255
db: KEGG Compound

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: O7P2
molecular weight: 173.91193
structure: ChemicalStructure/PW C000170

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Guanosine triphosphate
type: SmallMolecule
cellular location: Chloroplast
entity reference: Guanosine triphosphate
name: SubPathwayOutput

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

5-Amino-6-(D-ribitylamino)uracil
type: SmallMolecule
cellular location: Chloroplast
entity reference: 5-Amino-6-(D-ribitylamino)uracil

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/ChEBI CHEBI 17015
type: UnificationXref
id: CHEBI:17015
db: ChEBI

Reference/ChEBI CHEBI 15996
type: UnificationXref
id: CHEBI:15996
db: ChEBI

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

ChemicalStructure/PW C000479
type: ChemicalStructure
structure format: SMILES
structure data: OCC(=O)[C@H](O)[C@H](O)COP(O)(O)=O

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

Reference/HMDB HMDB0000244
type: UnificationXref
id: HMDB0000244
db: HMDB

Compound/PW C001420 Chloroplast/Stoichiometry/2.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 2.0

Reference/PubChem-compound 193516
type: UnificationXref
id: 193516
db: PubChem-compound

Water
type: SmallMolecule
cellular location: Chloroplast
entity reference: Water

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Compound/PW C000032 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

Reference/CAS 4151-19-3
type: UnificationXref
id: 4151-19-3
db: CAS

Reference/BioCyc DIMETHYL-D-RIBITYL-LUMAZINE
type: UnificationXref
id: DIMETHYL-D-RIBITYL-LUMAZINE
db: BioCyc

Monofunctional riboflavin biosynthesis protein RIBA 2, chloroplastic
type: Protein
cellular location: Chloroplast
entity reference: Monofunctional riboflavin biosynthesis protein RIBA 2, chloroplastic

Riboflavin biosynthesis protein PYRD, chloroplastic
type: Protein
cellular location: Chloroplast
entity reference: Riboflavin biosynthesis protein PYRD, chloroplastic

Reference/UniProt O80575
type: UnificationXref
id: O80575
db: UniProt

Reference/ChEBI CHEBI 17621
type: UnificationXref
id: CHEBI:17621
db: ChEBI

5-Amino-6-(5'-phospho-D-ribitylamino)uracil
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 18247
xref: Reference/PubChem-compound 18666812
xref: Reference/KEGG Compound C04454
xref: Reference/ChemSpider 18921533
chemical formula: C9H17N4O9P
molecular weight: 356.0733
structure: ChemicalStructure/PW C096927

Compound/PW C000143 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Compound/PW C000146 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Compound/PW C000964 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: FAD
stoichiometric coefficient: 1.0

Compound/PW C001170 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: Flavin Mononucleotide
stoichiometric coefficient: 1.0

5-Amino-6-(D-ribitylamino)uracil
type: SmallMoleculeReference
xref: Reference/PubChem-compound 193516
xref: Reference/KEGG Compound C04732
xref: Reference/ChEBI CHEBI 15934
xref: Reference/CAS 17014-74-3
xref: Reference/BioCyc AMINO-RIBOSYLAMINO-1H-3H-PYR-DIONE
xref: Reference/ChemSpider 167930
chemical formula: C9H16N4O6
molecular weight: 276.107
structure: ChemicalStructure/PW C096928

ChemicalStructure/PW C000964
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

Reference/ChemSpider 652
type: UnificationXref
id: 652
db: ChemSpider

D-Ribulose 5-phosphate
type: SmallMolecule
cellular location: Chloroplast
entity reference: D-Ribulose 5-phosphate
name: SubPathwayOutput

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])(=O)OP([O-])([O-])=O

Reference/UniProt P93740
type: UnificationXref
id: P93740
db: UniProt

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

6,7-dimethyl-8-ribityllumazine synthase, chloroplastic
type: ProteinReference
xref: Reference/UniProt O80575
organism: Arabidopsis thaliana

riboflavin synthase
type: ProteinReference
xref: Reference/UniProt Q9SKU8
organism: Arabidopsis thaliana

Riboflavin biosynthesis protein PYRD, chloroplastic
type: ProteinReference
xref: Reference/UniProt Q8GWP5
organism: Arabidopsis thaliana

Flavin mononucleotide hydrolase 1, chloroplatic
type: ProteinReference
xref: Reference/UniProt Q84VZ1
organism: Arabidopsis thaliana

Monofunctional riboflavin biosynthesis protein RIBA 2, chloroplastic
type: ProteinReference
xref: Reference/UniProt Q6NLQ7
organism: Arabidopsis thaliana

Riboflavin biosynthesis protein PYRR, chloroplastic
type: ProteinReference
xref: Reference/UniProt Q9STY4
organism: Arabidopsis thaliana

Reference/KEGG Compound C00044
type: UnificationXref
id: C00044
db: KEGG Compound

Compound/PW C042618 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-3,4-Dihydroxybutan-2-one 4-phosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
type: SmallMoleculeReference
xref: Reference/PubChem-compound 93581524
xref: Reference/KEGG Compound C01304
xref: Reference/BioCyc DIAMINO-OH-PHOSPHORIBOSYLAMINO-PYR
xref: Reference/ChEBI CHEBI 59546
chemical formula: C9H16N5O8P
molecular weight: 353.07364
structure: ChemicalStructure/PW C096932

Reference/ChemSpider 167930
type: UnificationXref
id: 167930
db: ChemSpider

Compound/PW C001420 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 18971002
type: UnificationXref
id: 18971002
db: PubChem-compound

Reference/UniProt Q9STY4
type: UnificationXref
id: Q9STY4
db: UniProt

Bifunctional riboflavin kinase/FMN phosphatase
type: ProteinReference
xref: Reference/UniProt Q84MD8
organism: Arabidopsis thaliana

Reference/HMDB HMDB0000142
type: UnificationXref
id: HMDB0000142
db: HMDB

Reference/ChEBI CHEBI 17601
type: UnificationXref
id: CHEBI:17601
db: ChEBI

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/PubChem-compound 643976
type: UnificationXref
id: 643976
db: PubChem-compound

Nudix hydrolase 23, chloroplastic
type: ProteinReference
xref: Reference/UniProt P93740
organism: Arabidopsis thaliana

Reference/PubChem-compound 643975
type: UnificationXref
id: 643975
db: PubChem-compound

6,7-Dimethyl-8-(1-D-ribityl)lumazine
type: SmallMoleculeReference
xref: Reference/CAS 5118-16-1
xref: Reference/ChEBI CHEBI 17601
xref: Reference/ChemSpider 652
xref: Reference/BioCyc DIMETHYL-D-RIBITYL-LUMAZINE
xref: Reference/HMDB HMDB0003826
xref: Reference/PubChem-compound 672
xref: Reference/KEGG Compound C04332
chemical formula: C13H18N4O6
molecular weight: 326.12262
structure: ChemicalStructure/PW C001973

Reaction108400
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001973 Chloroplast/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000165 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C096928 Chloroplast/Stoichiometry/1.0
right: Riboflavin
right: 5-Amino-6-(D-ribitylamino)uracil
spontaneous: false
left: 6,7-Dimethyl-8-(1-D-ribityl)lumazine
name: 2 6,7-Dimethyl-8-(1-D-ribityl)lumazine → 5-Amino-6-(D-ribitylamino)uracil + Riboflavin
conversion direction: LEFT_TO_RIGHT

Arabidopsis thaliana
type: BioSource
xref: Reference/TAXONOMY 3702

Reference/PubChem-compound 18666812
type: UnificationXref
id: 18666812
db: PubChem-compound

3.1.3.102,2.7.1.26
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000165 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001170 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Chloroplast/Stoichiometry/1.0
right: Adenosine diphosphate
right: Flavin Mononucleotide
spontaneous: false
EC number: 3.1.3.102,2.7.1.26
left: Adenosine triphosphate
left: Riboflavin
name: Adenosine triphosphate + Riboflavin → Adenosine diphosphate + Flavin Mononucleotide
conversion direction: LEFT_TO_RIGHT

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/KEGG Compound C00058
type: UnificationXref
id: C00058
db: KEGG Compound

3.6.1.18
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000964 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001170 Chloroplast/Stoichiometry/1.0
right: Adenosine monophosphate
right: Flavin Mononucleotide
spontaneous: false
EC number: 3.6.1.18
left: Water
left: FAD
name: FAD + Water → Adenosine monophosphate + Flavin Mononucleotide
conversion direction: LEFT_TO_RIGHT

3.1.3.104
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C096927 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C096928 Chloroplast/Stoichiometry/1.0
right: Phosphate
right: 5-Amino-6-(D-ribitylamino)uracil
spontaneous: false
EC number: 3.1.3.104
left: Water
left: 5-Amino-6-(5'-phospho-D-ribitylamino)uracil
name: 5-Amino-6-(5'-phospho-D-ribitylamino)uracil + Water → 5-Amino-6-(D-ribitylamino)uracil + Phosphate
conversion direction: LEFT_TO_RIGHT

5-Amino-6-(5'-phosphoribosylamino)uracil
type: SmallMolecule
cellular location: Chloroplast
entity reference: 5-Amino-6-(5'-phosphoribosylamino)uracil

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

Formic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 30751
xref: Reference/ChemSpider 278
xref: Reference/PubChem-compound 18971002
xref: Reference/BioCyc FORMATE
xref: Reference/CAS 64-18-6
xref: Reference/KEGG Compound C00058
xref: Reference/HMDB HMDB0000142
chemical formula: CH2O2
molecular weight: 46.005478
structure: ChemicalStructure/PW C000092

Reference/PathWhiz PW064424
type: UnificationXref
id: PW064424
db: PathWhiz

Reference/CAS 83-88-5
type: UnificationXref
id: 83-88-5
db: CAS

Reference/HMDB HMDB0001248
type: UnificationXref
id: HMDB0001248
db: HMDB

Reference/BioCyc AMMONIA
type: UnificationXref
id: AMMONIA
db: BioCyc

ChemicalStructure/PW C000035
type: ChemicalStructure
structure format: SMILES
structure data: N

Reference/KEGG Compound C00061
type: UnificationXref
id: C00061
db: KEGG Compound

SubPathwayInteraction57028
type: Interaction
name: SubPathway57028Reaction
name: SubPathwayReaction
participant: Guanosine triphosphate

Reference/BioCyc FORMATE
type: UnificationXref
id: FORMATE
db: BioCyc

SubPathwayInteraction57027
type: Interaction
name: SubPathway57027Reaction
name: SubPathwayReaction
participant: D-Ribulose 5-phosphate

ChemicalStructure/PW C041187
type: ChemicalStructure
structure format: SMILES

Pentose phosphate pathway
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway57027
pathway component: SubPathwayInteraction57027
name: SubPathway

Reference/CAS 146-17-8
type: UnificationXref
id: 146-17-8
db: CAS

Compound/PW C096932 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Purine metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway57028
pathway component: SubPathwayInteraction57028
name: SubPathway

Reference/BioCyc DIAMINO-OH-PHOSPHORIBOSYLAMINO-PYR
type: UnificationXref
id: DIAMINO-OH-PHOSPHORIBOSYLAMINO-PYR
db: BioCyc

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Reference/BioCyc RIBOFLAVIN
type: UnificationXref
id: RIBOFLAVIN
db: BioCyc

ChemicalStructure/PW C000165
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

Formic acid
type: SmallMolecule
cellular location: Chloroplast
entity reference: Formic acid

Nudix hydrolase 23, chloroplastic
type: Protein
cellular location: Chloroplast
entity reference: Nudix hydrolase 23, chloroplastic

Compound/PW C000165 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: Riboflavin
stoichiometric coefficient: 1.0

Compound/PW C000986 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine triphosphate
stoichiometric coefficient: 1.0

Reference/UniProt Q9SKU8
type: UnificationXref
id: Q9SKU8
db: UniProt

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

riboflavin synthase
type: Protein
cellular location: Chloroplast
entity reference: riboflavin synthase

Reference/SMPDB SMP0063462
type: UnificationXref
id: SMP0063462
db: SMPDB

Ammonia
type: SmallMolecule
cellular location: Chloroplast
entity reference: Ammonia

Flavin mononucleotide hydrolase 1, chloroplatic
type: Protein
cellular location: Chloroplast
entity reference: Flavin mononucleotide hydrolase 1, chloroplatic

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Reference/BioCyc RIBULOSE-5P
type: UnificationXref
id: RIBULOSE-5P
db: BioCyc

Reference/KEGG Compound C00199
type: UnificationXref
id: C00199
db: KEGG Compound

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reference/ChEBI CHEBI 30751
type: UnificationXref
id: CHEBI:30751
db: ChEBI

Adenosine triphosphate
type: SmallMolecule
cellular location: Chloroplast
entity reference: Adenosine triphosphate

Reference/HMDB HMDB0000051
type: UnificationXref
id: HMDB0000051
db: HMDB

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

ChemicalStructure/PW C000092
type: ChemicalStructure
structure format: SMILES
structure data: OC=O

5-Amino-6-(5'-phosphoribosylamino)uracil
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 18337
xref: Reference/PubChem-compound 439462
chemical formula: C9H15N4O9P
molecular weight: 354.05768
structure: ChemicalStructure/PW C041187

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/CAS 146-14-5
type: UnificationXref
id: 146-14-5
db: CAS

Chloroplast
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0009507

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

D-Ribulose 5-phosphate
type: SmallMoleculeReference
xref: Reference/CAS 4151-19-3
xref: Reference/BioCyc RIBULOSE-5P
xref: Reference/KEGG Compound C00199
xref: Reference/PubChem-compound 439184
xref: Reference/HMDB HMDB0000618
xref: Reference/ChEBI CHEBI 17363
chemical formula: C5H11O8P
molecular weight: 230.01915
structure: ChemicalStructure/PW C000479

Reference/ChemSpider 6569
type: UnificationXref
id: 6569
db: ChemSpider

Compound/PW C001104 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Reference/BioCyc GTP
type: UnificationXref
id: GTP
db: BioCyc

Reference/HMDB HMDB0000618
type: UnificationXref
id: HMDB0000618
db: HMDB

Compound/PW C096927 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Amino-6-(5'-phospho-D-ribitylamino)uracil
stoichiometric coefficient: 1.0

Compound/PW C001973 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: 6,7-Dimethyl-8-(1-D-ribityl)lumazine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 439462
type: UnificationXref
id: 439462
db: PubChem-compound

NADPH
type: SmallMolecule
cellular location: Chloroplast
entity reference: NADPH

Reference/HMDB HMDB0001273
type: UnificationXref
id: HMDB0001273
db: HMDB

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

ChemicalStructure/PW C000986
type: ChemicalStructure
structure format: SMILES

Reference/CAS 64-18-6
type: UnificationXref
id: 64-18-6
db: CAS

Reference/KEGG Compound C04454
type: UnificationXref
id: C04454
db: KEGG Compound

Reference/KEGG Compound C04332
type: UnificationXref
id: C04332
db: KEGG Compound

Adenosine diphosphate
type: SmallMolecule
cellular location: Chloroplast
entity reference: Adenosine diphosphate

Flavin Mononucleotide
type: SmallMolecule
cellular location: Chloroplast
entity reference: Flavin Mononucleotide

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

L-3,4-Dihydroxybutan-2-one 4-phosphate
type: SmallMolecule
cellular location: Chloroplast
entity reference: L-3,4-Dihydroxybutan-2-one 4-phosphate

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

5-Amino-6-(5'-phospho-D-ribitylamino)uracil
type: SmallMolecule
cellular location: Chloroplast
entity reference: 5-Amino-6-(5'-phospho-D-ribitylamino)uracil

Reference/BioCyc FAD
type: UnificationXref
id: FAD
db: BioCyc

Reference/CAS 86-01-1
type: UnificationXref
id: 86-01-1
db: CAS

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

FAD
type: SmallMolecule
cellular location: Chloroplast
entity reference: FAD

L-3,4-Dihydroxybutan-2-one 4-phosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 50608
chemical formula: C4H9O6P
molecular weight: 184.01367
structure: ChemicalStructure/PW C042618

Compound/PW C001973 Chloroplast/Stoichiometry/2.0
type: Stoichiometry
physical entity: 6,7-Dimethyl-8-(1-D-ribityl)lumazine
stoichiometric coefficient: 2.0

ChemicalStructure/PW C001973
type: ChemicalStructure
structure format: SMILES

Riboflavin biosynthesis protein PYRR, chloroplastic
type: Protein
cellular location: Chloroplast
entity reference: Riboflavin biosynthesis protein PYRR, chloroplastic

6,7-Dimethyl-8-(1-D-ribityl)lumazine
type: SmallMolecule
cellular location: Chloroplast
entity reference: 6,7-Dimethyl-8-(1-D-ribityl)lumazine

ChemicalStructure/PW C001170
type: ChemicalStructure
structure format: SMILES