Reference/PubChem-compound 247
type: UnificationXref
id: 247
db: PubChem-compound

Reference/CAS 454-29-5
type: UnificationXref
id: 454-29-5
db: CAS

Betaine Metabolism
type: Pathway
pathway order: PathwayEnzymeReaction/1189473
pathway order: PathwayEnzymeReaction/1189472
pathway order: PathwayTransport/1189478
pathway order: PathwayEnzymeReaction/1189475
pathway order: PathwayTransport/1189477
pathway order: PathwayEnzymeReaction/1189474
pathway order: PathwayEnzymeReaction/1189476
pathway order: PathwaySubPathway/57477
pathway order: PathwayEnzymeReaction/1189471
pathway order: PathwayEnzymeReaction/1189470
pathway component: 2.5.1.6
pathway component: 3.3.1.1
pathway component: 1.1.99.1
pathway component: Reaction109817
pathway component: One Carbon Pool by Folate
pathway component: ReactionCatalysis100094
pathway component: ReactionCatalysis100093
pathway component: ReactionCatalysis100092
pathway component: ReactionCatalysis100091
pathway component: Reaction109811
pathway component: 2.1.1.5
pathway component: 2.1.1.13
pathway component: ReactionCatalysis100097
pathway component: ReactionCatalysis100096
pathway component: ReactionCatalysis100095
pathway component: Transport1052
pathway component: Transport1051
xref: Reference/SMPDB SMP0063600
xref: Reference/PathWhiz PW064576
organism: Mus musculus

Reference/PubChem-compound 249
type: UnificationXref
id: 249
db: PubChem-compound

Protein/13768 Cytoplasm/Stoichiometry/4.0
type: Stoichiometry
physical entity: S-methylmethionine--homocysteine S-methyltransferase BHMT2
stoichiometric coefficient: 4.0

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Protein/14285 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Methionine adenosyltransferase 2 subunit beta
stoichiometric coefficient: 1.0

Reference/KEGG Compound C05330
type: UnificationXref
id: C05330
db: KEGG Compound

Reference/UniProt Q61907
type: UnificationXref
id: Q61907
db: UniProt

Compound/PW C000749 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylhomocysteine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/HMDB HMDB0000092
type: UnificationXref
id: HMDB0000092
db: HMDB

Adenosine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 60961
xref: Reference/ChEBI CHEBI 16335
xref: Reference/ChemSpider 54923
xref: Reference/HMDB HMDB0000050
xref: Reference/CAS 58-61-7
xref: Reference/KEGG Compound C00212
xref: Reference/BioCyc ADENOSINE
chemical formula: C10H13N5O4
molecular weight: 267.09674
structure: ChemicalStructure/PW C000034

Tetrahydrofolic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Tetrahydrofolic acid
name: SubPathwayInput

Reference/ChEBI CHEBI 15958
type: UnificationXref
id: CHEBI:15958
db: ChEBI

Reference/HMDB HMDB0000097
type: UnificationXref
id: HMDB0000097
db: HMDB

Reference/HMDB HMDB0001185
type: UnificationXref
id: HMDB0001185
db: HMDB

βine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 247
xref: Reference/BioCyc BETAINE
xref: Reference/ChemSpider 242
xref: Reference/KEGG Compound C00719
xref: Reference/CAS 107-43-7
xref: Reference/ChEBI CHEBI 17750
xref: Reference/HMDB HMDB0000043
chemical formula: C5H11NO2
molecular weight: 117.07898
structure: ChemicalStructure/PW C000030

Reference/ChEBI CHEBI 20506
type: UnificationXref
id: CHEBI:20506
db: ChEBI

Reference/HMDB HMDB0061372
type: UnificationXref
id: HMDB0061372
db: HMDB

Reference/HMDB HMDB0061371
type: UnificationXref
id: HMDB0061371
db: HMDB

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

βine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: βine

Reference/ChEBI CHEBI 17230
type: UnificationXref
id: CHEBI:17230
db: ChEBI

Reference/KEGG Compound C00440
type: UnificationXref
id: C00440
db: KEGG Compound

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/PubChem-compound 6137
type: UnificationXref
id: 6137
db: PubChem-compound

Reference/BioCyc 5-METHYL-THF
type: UnificationXref
id: 5-METHYL-THF
db: BioCyc

Homocysteine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Homocysteine

Compound/PW C000967 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: βine aldehyde
stoichiometric coefficient: 1.0

Reference/ChemSpider 18714427
type: UnificationXref
id: 18714427
db: ChemSpider

Reference/ChemSpider 244
type: UnificationXref
id: 244
db: ChemSpider

Water
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Water

Reference/ChemSpider 242
type: UnificationXref
id: 242
db: ChemSpider

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

βine
type: SmallMolecule
cellular location: Mitochondrion
entity reference: βine

Reference/PubChem-compound 49791978
type: UnificationXref
id: 49791978
db: PubChem-compound

S-Adenosylmethionine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24762165
xref: Reference/KEGG Compound C00019
xref: Reference/ChemSpider 31983
xref: Reference/ChEBI CHEBI 15414
xref: Reference/CAS 485-80-3
xref: Reference/BioCyc S-ADENOSYLMETHIONINE
xref: Reference/HMDB HMDB0001185
chemical formula: C15H23N6O5S
molecular weight: 399.14505
structure: ChemicalStructure/PW C000921

Reference/TAXONOMY 10090
type: UnificationXref
id: 10090
db: TAXONOMY

Reference/UniProt A6H5Y3
type: UnificationXref
id: A6H5Y3
db: UniProt

Compound/PW C000921 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylmethionine
stoichiometric coefficient: 1.0

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Alpha-aminoadipic semialdehyde dehydrogenase
type: Complex
component stoichiometry: Protein/13682 Mitochondrion/Stoichiometry/4.0
cellular location: Mitochondrion
component: Succinate-semialdehyde dehydrogenase, mitochondrial

Reference/KEGG Compound C00576
type: UnificationXref
id: C00576
db: KEGG Compound

S-adenosylhomocysteine hydrolase-like protein 1
type: Protein
cellular location: Cytosol
entity reference: S-adenosylhomocysteine hydrolase-like protein 1

Reference/KEGG Compound C00212
type: UnificationXref
id: C00212
db: KEGG Compound

ChemicalStructure/PW C000548
type: ChemicalStructure
structure format: SMILES
structure data: CSCC[C@H](N)C(O)=O

Reference/ChEBI CHEBI 15022
type: UnificationXref
id: CHEBI:15022
db: ChEBI

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Tetrahydrofolic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 20506
xref: Reference/ChemSpider 18714427
xref: Reference/HMDB HMDB0001846
xref: Reference/PubChem-compound 13781857
xref: Reference/BioCyc THF
xref: Reference/CAS 135-16-0
xref: Reference/KEGG Compound C00101
chemical formula: C19H23N7O6
molecular weight: 445.171
structure: ChemicalStructure/PW C001221

Compound/PW C000030 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: βine
stoichiometric coefficient: 1.0

Reference/BioCyc BETAINE ALDEHYDE
type: UnificationXref
id: BETAINE_ALDEHYDE
db: BioCyc

Reference/CAS 107-43-7
type: UnificationXref
id: 107-43-7
db: CAS

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Reference/BioCyc ADENOSYL-HOMO-CYS
type: UnificationXref
id: ADENOSYL-HOMO-CYS
db: BioCyc

Compound/PW C000034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15710
type: UnificationXref
id: CHEBI:15710
db: ChEBI

Reference/CAS 485-80-3
type: UnificationXref
id: 485-80-3
db: CAS

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: O4P
molecular weight: 94.95342
structure: ChemicalStructure/PW C001104

Reference/CAS 7418-61-3
type: UnificationXref
id: 7418-61-3
db: CAS

Reference/KEGG Compound C00101
type: UnificationXref
id: C00101
db: KEGG Compound

Compound/PW C000921 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylmethionine
stoichiometric coefficient: 1.0

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Compound/PW C000030 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: βine
stoichiometric coefficient: 1.0

Mus musculus
type: BioSource
xref: Reference/TAXONOMY 10090

Mitochondrion
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005739

Reference/BioCyc THF
type: UnificationXref
id: THF
db: BioCyc

Reference/ChEBI CHEBI 15641
type: UnificationXref
id: CHEBI:15641
db: ChEBI

ChemicalStructure/PW C000921
type: ChemicalStructure
structure format: SMILES

Reference/CAS 979-92-0
type: UnificationXref
id: 979-92-0
db: CAS

Methionine adenosyltransferase 2 subunit beta
type: Protein
cellular location: Cytoplasm
entity reference: Methionine adenosyltransferase 2 subunit beta

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Compound/PW C000030 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: βine
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00114
type: UnificationXref
id: C00114
db: KEGG Compound

S-Adenosylhomocysteine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 25246222
xref: Reference/ChemSpider 388301
xref: Reference/BioCyc ADENOSYL-HOMO-CYS
xref: Reference/CAS 979-92-0
xref: Reference/KEGG Compound C00021
xref: Reference/ChEBI CHEBI 16680
xref: Reference/HMDB HMDB0000939
chemical formula: C14H20N6O5S
molecular weight: 384.12158
structure: ChemicalStructure/PW C000749

Choline dehydrogenase, mitochondrial
type: Protein
cellular location: Cytosol
entity reference: Choline dehydrogenase, mitochondrial

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

ChemicalStructure/PW C001221
type: ChemicalStructure
structure format: SMILES

Water
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Water

Reference/HMDB HMDB0000696
type: UnificationXref
id: HMDB0000696
db: HMDB

S-adenosylmethionine synthase isoform type-2
type: Protein
cellular location: Cytoplasm
entity reference: S-adenosylmethionine synthase isoform type-2

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])([O-])=O

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

S-adenosylmethionine synthase
type: Complex
component stoichiometry: Protein/14102 Cytoplasm/Stoichiometry/2.0
component stoichiometry: Protein/14285 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: S-adenosylmethionine synthase isoform type-2
component: Methionine adenosyltransferase 2 subunit beta

5-Methyltetrahydrofolic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 5-Methyltetrahydrofolic acid
name: SubPathwayOutput

Reference/ChEBI CHEBI 15414
type: UnificationXref
id: CHEBI:15414
db: ChEBI

Choline
type: SmallMolecule
cellular location: Cytosol
entity reference: Choline

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Adenosine
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine

Compound/PW C040696 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidyl-ethanolamide
stoichiometric coefficient: 1.0

Acceptor
type: SmallMolecule
cellular location: Cytosol
entity reference: Acceptor

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/PubChem-compound 673
type: UnificationXref
id: 673
db: PubChem-compound

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/CAS 135-16-0
type: UnificationXref
id: 135-16-0
db: CAS

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

SubPathwayInteraction57477
type: Interaction
name: SubPathway57477Reaction
name: SubPathwayReaction
participant: 5-Methyltetrahydrofolic acid
participant: Tetrahydrofolic acid

βine aldehyde
type: SmallMoleculeReference
xref: Reference/ChemSpider 244
xref: Reference/ChEBI CHEBI 15710
xref: Reference/PubChem-compound 249
xref: Reference/BioCyc BETAINE ALDEHYDE
xref: Reference/CAS 7418-61-3
xref: Reference/HMDB HMDB0001252
xref: Reference/KEGG Compound C00576
chemical formula: C5H12NO
molecular weight: 102.09189
structure: ChemicalStructure/PW C000967

Reference/KEGG Compound C00019
type: UnificationXref
id: C00019
db: KEGG Compound

Reference/PubChem-compound 60961
type: UnificationXref
id: 60961
db: PubChem-compound

Compound/Generic40 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Reduced acceptor
stoichiometric coefficient: 1.0

One Carbon Pool by Folate
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway57477
pathway component: SubPathwayInteraction57477
name: SubPathway

S-adenosylmethionine synthase isoform type-2
type: ProteinReference
xref: Reference/UniProt Q3THS6
organism: Mus musculus

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H28N7O14P2
molecular weight: 664.11694
structure: ChemicalStructure/PW C000721

Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine triphosphate

Reference/BioCyc S-ADENOSYLMETHIONINE
type: UnificationXref
id: S-ADENOSYLMETHIONINE
db: BioCyc

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Homocysteine
type: SmallMolecule
cellular location: Cytosol
entity reference: Homocysteine

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: O7P2
molecular weight: 173.91193
structure: ChemicalStructure/PW C000170

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Compound/Generic41 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acceptor
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/SMPDB SMP0063600
type: UnificationXref
id: SMP0063600
db: SMPDB

Compound/PW C040695 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidyl-N-methylethanolamine
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000590
type: ChemicalStructure
structure format: SMILES
structure data: NC(CCS)C(O)=O

Compound/PW C000548 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Methionine
stoichiometric coefficient: 1.0

Phosphatidyl-N-methylethanolamine
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphatidyl-N-methylethanolamine

ChemicalStructure/PW C040696
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 388301
type: UnificationXref
id: 388301
db: ChemSpider

ChemicalStructure/PW C040695
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc CPD-563
type: UnificationXref
id: CPD-563
db: BioCyc

Reference/BioCyc MET
type: UnificationXref
id: MET
db: BioCyc

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/KEGG Compound C00021
type: UnificationXref
id: C00021
db: KEGG Compound

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/UniProt Q8BJ64
type: UnificationXref
id: Q8BJ64
db: UniProt

Compound/PW C001144 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Compound/PW C000062 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dimethylglycine
stoichiometric coefficient: 1.0

Adenosylhomocysteinase
type: Complex
component stoichiometry: Protein/13683 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: S-adenosylhomocysteine hydrolase-like protein 1

Reference/GENE ONTOLOGY GO 0005739
type: UnificationXref
id: GO:0005739
db: GENE ONTOLOGY

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Reference/CAS 1118-68-9
type: UnificationXref
id: 1118-68-9
db: CAS

Compound/PW C000065 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Choline
stoichiometric coefficient: 1.0

Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Choline
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15354
xref: Reference/ChemSpider 299
xref: Reference/BioCyc CPD-563
xref: Reference/PubChem-compound 305
xref: Reference/CAS 62-49-7
xref: Reference/HMDB HMDB0000097
xref: Reference/KEGG Compound C00114
chemical formula: C5H14NO
molecular weight: 104.10754
structure: ChemicalStructure/PW C000065

Dimethylglycine
type: SmallMoleculeReference
xref: Reference/BioCyc DIMETHYL-GLYCINE
xref: Reference/ChemSpider 653
xref: Reference/CAS 1118-68-9
xref: Reference/ChEBI CHEBI 17724
xref: Reference/HMDB HMDB0000092
xref: Reference/PubChem-compound 673
xref: Reference/KEGG Compound C01026
chemical formula: C4H9NO2
molecular weight: 103.06333
structure: ChemicalStructure/PW C000062

L-Methionine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000696
xref: Reference/ChEBI CHEBI 16643
xref: Reference/KEGG Compound C00073
xref: Reference/CAS 63-68-3
xref: Reference/BioCyc MET
xref: Reference/PubChem-compound 6137
xref: Reference/ChemSpider 5907
chemical formula: C5H11NO2S
molecular weight: 149.05106
structure: ChemicalStructure/PW C000548

Phosphatidyl-ethanolamide
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphatidyl-ethanolamide

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Reference/PathWhiz PW064576
type: UnificationXref
id: PW064576
db: PathWhiz

ChemicalStructure/PW C000967
type: ChemicalStructure
structure format: SMILES
structure data: C[N+](C)(C)CC=O

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 653
type: UnificationXref
id: 653
db: ChemSpider

Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00719
type: UnificationXref
id: C00719
db: KEGG Compound

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])(=O)OP([O-])([O-])=O

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Phosphatidyl-N-methylethanolamine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 4462
xref: Reference/HMDB HMDB0061372
xref: Reference/ChEBI CHEBI 15958
chemical formula: C36H69NO8P
molecular weight: 674.4761
structure: ChemicalStructure/PW C040695

Phosphatidyl-ethanolamide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0061371
chemical formula: C35H66NO8P
molecular weight: 659.4526
structure: ChemicalStructure/PW C040696

S-adenosylhomocysteine hydrolase-like protein 1
type: ProteinReference
xref: Reference/UniProt Q80SW1
organism: Mus musculus

Reference/ChEBI CHEBI 15339
type: UnificationXref
id: CHEBI:15339
db: ChEBI

Succinate-semialdehyde dehydrogenase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q8BWF0
organism: Mus musculus

Reference/ChEBI CHEBI 17750
type: UnificationXref
id: CHEBI:17750
db: ChEBI

S-Adenosylmethionine
type: SmallMolecule
cellular location: Cytosol
entity reference: S-Adenosylmethionine

Reference/HMDB HMDB0000939
type: UnificationXref
id: HMDB0000939
db: HMDB

ChemicalStructure/PW C000065
type: ChemicalStructure
structure format: SMILES
structure data: C[N+](C)(C)CCO

Betaine--homocysteine S-methyltransferase 1
type: Complex
component stoichiometry: Protein/13768 Cytoplasm/Stoichiometry/4.0
cellular location: Cytoplasm
component: S-methylmethionine--homocysteine S-methyltransferase BHMT2

Dimethylglycine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Dimethylglycine

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Transport1052
type: Transport
participant stoichiometry: Compound/PW C000065 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000065 Extracellular Space/Stoichiometry/1.0
right: Choline
spontaneous: false
left: Choline
name: Choline (→) Transport: Mus musculus, Extracellular Space to Mus musculus, Cell, Mitochondrion
conversion direction: LEFT_TO_RIGHT

Transport1051
type: Transport
participant stoichiometry: Compound/PW C000030 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000030 Mitochondrion/Stoichiometry/1.0
right: βine
spontaneous: false
left: βine
name: βine (→) Transport: Mus musculus, Extracellular Space to Mus musculus, Cell, Mitochondrion
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000062
type: ChemicalStructure
structure format: SMILES
structure data: CN(C)CC(O)=O

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/ChEBI CHEBI 17724
type: UnificationXref
id: CHEBI:17724
db: ChEBI

Reference/PubChem-compound 305
type: UnificationXref
id: 305
db: PubChem-compound

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Acceptor
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15339

Reduced acceptor
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15022

Reference/KEGG Compound C01026
type: UnificationXref
id: C01026
db: KEGG Compound

NAD
type: SmallMolecule
cellular location: Mitochondrion
entity reference: NAD

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

ChemicalStructure/PW C000030
type: ChemicalStructure
structure format: SMILES
structure data: C[N+](C)(C)CC([O-])=O

L-Methionine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Methionine

Protein/13683 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: S-adenosylhomocysteine hydrolase-like protein 1
stoichiometric coefficient: 4.0

ChemicalStructure/PW C000034
type: ChemicalStructure
structure format: SMILES

Reference/CAS 63-68-3
type: UnificationXref
id: 63-68-3
db: CAS

Compound/PW C001221 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tetrahydrofolic acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 5907
type: UnificationXref
id: 5907
db: ChemSpider

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Reference/UniProt Q91WS4
type: UnificationXref
id: Q91WS4
db: UniProt

Reference/ChEBI CHEBI 16643
type: UnificationXref
id: CHEBI:16643
db: ChEBI

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Methionine synthase
type: Protein
cellular location: Cytoplasm
entity reference: Methionine synthase

Reference/CAS 58-61-7
type: UnificationXref
id: 58-61-7
db: CAS

Pyrophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pyrophosphate

Protein/14102 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: S-adenosylmethionine synthase isoform type-2
stoichiometric coefficient: 2.0

S-Adenosylhomocysteine
type: SmallMolecule
cellular location: Cytosol
entity reference: S-Adenosylhomocysteine

Compound/PW C000967 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: βine aldehyde
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00073
type: UnificationXref
id: C00073
db: KEGG Compound

5-Methyltetrahydrofolic acid
type: SmallMoleculeReference
xref: Reference/BioCyc 5-METHYL-THF
xref: Reference/ChEBI CHEBI 15641
xref: Reference/PubChem-compound 439234
xref: Reference/CAS 134-35-0
xref: Reference/KEGG Compound C00440
xref: Reference/ChemSpider 388371
xref: Reference/HMDB HMDB0001396
chemical formula: C20H25N7O6
molecular weight: 459.18665
structure: ChemicalStructure/PW C001079

S-methylmethionine--homocysteine S-methyltransferase BHMT2
type: Protein
cellular location: Cytoplasm
entity reference: S-methylmethionine--homocysteine S-methyltransferase BHMT2

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001252
type: UnificationXref
id: HMDB0001252
db: HMDB

NADH
type: SmallMolecule
cellular location: Mitochondrion
entity reference: NADH

Reference/HMDB HMDB0000043
type: UnificationXref
id: HMDB0000043
db: HMDB

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Compound/PW C000590 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Homocysteine
stoichiometric coefficient: 1.0

Reference/BioCyc DIMETHYL-GLYCINE
type: UnificationXref
id: DIMETHYL-GLYCINE
db: BioCyc

Reference/ChemSpider 31983
type: UnificationXref
id: 31983
db: ChemSpider

Reference/ChEBI CHEBI 16335
type: UnificationXref
id: CHEBI:16335
db: ChEBI

Phosphatidylethanolamine N-methyltransferase
type: ProteinReference
xref: Reference/UniProt Q61907
organism: Mus musculus

Methionine adenosyltransferase 2 subunit beta
type: ProteinReference
xref: Reference/UniProt Q99LB6
organism: Mus musculus

ReactionCatalysis100094
type: Catalysis
controller: S-adenosylmethionine synthase
controlled: 2.5.1.6
control type: ACTIVATION

ReactionCatalysis100093
type: Catalysis
controller: Methionine synthase
controlled: 2.1.1.13
control type: ACTIVATION

ReactionCatalysis100092
type: Catalysis
controller: Betaine--homocysteine S-methyltransferase 1
controlled: 2.1.1.5
control type: ACTIVATION

ReactionCatalysis100091
type: Catalysis
controller: Alpha-aminoadipic semialdehyde dehydrogenase
controlled: Reaction109811
control type: ACTIVATION

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/PubChem-compound 439234
type: UnificationXref
id: 439234
db: PubChem-compound

Reference/BioCyc BETAINE
type: UnificationXref
id: BETAINE
db: BioCyc

βine aldehyde
type: SmallMolecule
cellular location: Mitochondrion
entity reference: βine aldehyde

Reference/ChemSpider 299
type: UnificationXref
id: 299
db: ChemSpider

ReactionCatalysis100097
type: Catalysis
controller: Phosphatidylethanolamine N-methyltransferase
controlled: Reaction109817
control type: ACTIVATION

ReactionCatalysis100096
type: Catalysis
controller: Choline dehydrogenase, mitochondrial
controlled: 1.1.99.1
control type: ACTIVATION

ReactionCatalysis100095
type: Catalysis
controller: Adenosylhomocysteinase
controlled: 3.3.1.1
control type: ACTIVATION

Succinate-semialdehyde dehydrogenase, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Succinate-semialdehyde dehydrogenase, mitochondrial

Reference/HMDB HMDB0000050
type: UnificationXref
id: HMDB0000050
db: HMDB

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Homocysteine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C05330
xref: Reference/CAS 454-29-5
xref: Reference/HMDB HMDB0000742
xref: Reference/ChEBI CHEBI 17230
xref: Reference/ChemSpider 757
xref: Reference/PubChem-compound 49791978
xref: Reference/BioCyc HOMO-CYS
chemical formula: C4H9NO2S
molecular weight: 135.0354
structure: ChemicalStructure/PW C000590

Reference/BioCyc ADENOSINE
type: UnificationXref
id: ADENOSINE
db: BioCyc

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Phosphatidylethanolamine N-methyltransferase
type: Protein
cellular location: Cytosol
entity reference: Phosphatidylethanolamine N-methyltransferase

Methionine synthase
type: ProteinReference
xref: Reference/UniProt A6H5Y3
organism: Mus musculus

Reference/UniProt Q8BWF0
type: UnificationXref
id: Q8BWF0
db: UniProt

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Compound/PW C000590 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Homocysteine
stoichiometric coefficient: 1.0

Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphate

Reference/BioCyc HOMO-CYS
type: UnificationXref
id: HOMO-CYS
db: BioCyc

Reference/HMDB HMDB0000742
type: UnificationXref
id: HMDB0000742
db: HMDB

ChemicalStructure/PW C001079
type: ChemicalStructure
structure format: SMILES

S-methylmethionine--homocysteine S-methyltransferase BHMT2
type: ProteinReference
xref: Reference/UniProt Q91WS4
organism: Mus musculus

Reference/UniProt Q99LB6
type: UnificationXref
id: Q99LB6
db: UniProt

Reference/HMDB HMDB0001396
type: UnificationXref
id: HMDB0001396
db: HMDB

2.5.1.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000921 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000548 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
right: S-Adenosylmethionine
right: Phosphate
right: Pyrophosphate
spontaneous: false
EC number: 2.5.1.6
left: L-Methionine
left: Water
left: Adenosine triphosphate
name: Adenosine triphosphate + L-Methionine + Water → Phosphate + Pyrophosphate + S-Adenosylmethionine
conversion direction: LEFT_TO_RIGHT

3.3.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000749 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000590 Cytosol/Stoichiometry/1.0
right: Adenosine
right: Homocysteine
spontaneous: false
EC number: 3.3.1.1
left: S-Adenosylhomocysteine
left: Water
name: S-Adenosylhomocysteine + Water → Adenosine + Homocysteine
conversion direction: LEFT_TO_RIGHT

1.1.99.1
type: BiochemicalReaction
participant stoichiometry: Compound/Generic40 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000967 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic41 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000065 Cytosol/Stoichiometry/1.0
right: Reduced acceptor
right: βine aldehyde
spontaneous: false
EC number: 1.1.99.1
left: Choline
left: Acceptor
name: Acceptor + Choline → Reduced acceptor + βine aldehyde
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 4462
type: UnificationXref
id: 4462
db: PubChem-compound

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Choline dehydrogenase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q8BJ64
organism: Mus musculus

Reaction109817
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000749 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040696 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040695 Cytosol/Stoichiometry/1.0
right: S-Adenosylhomocysteine
right: Phosphatidyl-N-methylethanolamine
spontaneous: false
left: Phosphatidyl-ethanolamide
left: S-Adenosylmethionine
name: Phosphatidyl-ethanolamide + S-Adenosylmethionine → Phosphatidyl-N-methylethanolamine + S-Adenosylhomocysteine
conversion direction: LEFT_TO_RIGHT

βine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: βine

Reference/ChemSpider 388371
type: UnificationXref
id: 388371
db: ChemSpider

Compound/PW C001079 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Methyltetrahydrofolic acid
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000749
type: ChemicalStructure
structure format: SMILES

Reaction109811
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001144 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000967 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000030 Mitochondrion/Stoichiometry/1.0
right: NADH
right: βine
spontaneous: false
left: NAD
left: Water
left: βine aldehyde
name: NAD + Water + βine aldehyde → NADH + βine
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 757
type: UnificationXref
id: 757
db: ChemSpider

2.1.1.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000590 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000062 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000030 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000548 Cytoplasm/Stoichiometry/1.0
right: L-Methionine
right: Dimethylglycine
spontaneous: false
EC number: 2.1.1.5
left: Homocysteine
left: βine
name: Homocysteine + βine → Dimethylglycine + L-Methionine
conversion direction: LEFT_TO_RIGHT

2.1.1.13
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000590 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001221 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001079 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000548 Cytoplasm/Stoichiometry/1.0
right: L-Methionine
right: Tetrahydrofolic acid
spontaneous: false
EC number: 2.1.1.13
left: Homocysteine
left: 5-Methyltetrahydrofolic acid
name: 5-Methyltetrahydrofolic acid + Homocysteine → L-Methionine + Tetrahydrofolic acid
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 25246222
type: UnificationXref
id: 25246222
db: PubChem-compound

Compound/PW C000065 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Choline
stoichiometric coefficient: 1.0

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/ChemSpider 54923
type: UnificationXref
id: 54923
db: ChemSpider

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Reference/UniProt Q80SW1
type: UnificationXref
id: Q80SW1
db: UniProt

Protein/13682 Mitochondrion/Stoichiometry/4.0
type: Stoichiometry
physical entity: Succinate-semialdehyde dehydrogenase, mitochondrial
stoichiometric coefficient: 4.0

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Choline
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Choline

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/ChEBI CHEBI 15354
type: UnificationXref
id: CHEBI:15354
db: ChEBI

Reduced acceptor
type: SmallMolecule
cellular location: Cytosol
entity reference: Reduced acceptor

Reference/HMDB HMDB0001846
type: UnificationXref
id: HMDB0001846
db: HMDB

Reference/ChEBI CHEBI 16680
type: UnificationXref
id: CHEBI:16680
db: ChEBI

Compound/PW C000065 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Choline
stoichiometric coefficient: 1.0

Reference/CAS 62-49-7
type: UnificationXref
id: 62-49-7
db: CAS

βine aldehyde
type: SmallMolecule
cellular location: Cytosol
entity reference: βine aldehyde

Reference/PubChem-compound 24762165
type: UnificationXref
id: 24762165
db: PubChem-compound

Choline
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Choline

Reference/CAS 134-35-0
type: UnificationXref
id: 134-35-0
db: CAS

Compound/PW C000721 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/PubChem-compound 13781857
type: UnificationXref
id: 13781857
db: PubChem-compound

S-Adenosylmethionine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: S-Adenosylmethionine

Reference/UniProt Q3THS6
type: UnificationXref
id: Q3THS6
db: UniProt