Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Unknown
type: ProteinReference
organism: Mus musculus

Protein/7780 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 28919
type: UnificationXref
id: CHEBI:28919
db: ChEBI

Unknown
type: ProteinReference
organism: Mus musculus

Compound/PW C000749 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylhomocysteine
stoichiometric coefficient: 1.0

Unknown
type: ProteinReference
organism: Mus musculus

Unknown
type: ProteinReference
organism: Mus musculus

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

2-Hydroxyestrone
type: SmallMolecule
cellular location: Cytosol
entity reference: 2-Hydroxyestrone

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/HMDB HMDB0001185
type: UnificationXref
id: HMDB0001185
db: HMDB

UDP-glucuronosyltransferase 1-1
type: Complex
component stoichiometry: Protein/7782 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
component stoichiometry: Protein/7736 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
component stoichiometry: Protein/7780 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
component stoichiometry: Protein/7781 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
cellular location: Endoplasmic Reticulum Membrane
component: Unknown

Reference/CAS 2616-64-0
type: UnificationXref
id: 2616-64-0
db: CAS

NADPH
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: NADPH

Compound/PW C000143 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Estradiol 17-beta-dehydrogenase 11
type: Protein
cellular location: Cytosol
entity reference: Estradiol 17-beta-dehydrogenase 11

Reference/ChEBI CHEBI 17474
type: UnificationXref
id: CHEBI:17474
db: ChEBI

Uridine diphosphate glucuronic acid
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Uridine diphosphate glucuronic acid

Compound/PW C000146 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000100
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Transmembrane O-methyltransferase homolog
type: Protein
cellular location: Cytosol
entity reference: Transmembrane O-methyltransferase homolog

Compound/PW C001101 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Estrone sulfate
stoichiometric coefficient: 1.0

Adenosine 3',5'-diphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17985
xref: Reference/CAS 1053-73-2
xref: Reference/PubChem-compound 159296
xref: Reference/ChemSpider 140102
xref: Reference/BioCyc 3-5-ADP
xref: Reference/KEGG Compound C00054
xref: Reference/HMDB HMDB0000061
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C000043

Reference/PubChem-compound 5870
type: UnificationXref
id: 5870
db: PubChem-compound

S-Adenosylmethionine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24762165
xref: Reference/KEGG Compound C00019
xref: Reference/ChemSpider 31983
xref: Reference/ChEBI CHEBI 15414
xref: Reference/CAS 485-80-3
xref: Reference/BioCyc S-ADENOSYLMETHIONINE
xref: Reference/HMDB HMDB0001185
chemical formula: C15H23N6O5S
molecular weight: 399.14505
structure: ChemicalStructure/PW C000921

Reference/TAXONOMY 10090
type: UnificationXref
id: 10090
db: TAXONOMY

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

2-Methoxyestrone
type: SmallMoleculeReference
xref: Reference/KEGG Compound C05299
xref: Reference/ChEBI CHEBI 1189
xref: Reference/ChemSpider 389515
xref: Reference/PubChem-compound 440624
xref: Reference/HMDB HMDB0000010
xref: Reference/CAS 362-08-3
chemical formula: C19H24O3
molecular weight: 300.17255
structure: ChemicalStructure/PW C000005

Compound/PW C000921 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylmethionine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5756
type: UnificationXref
id: 5756
db: PubChem-compound

Reference/PubChem-compound 5757
type: UnificationXref
id: 5757
db: PubChem-compound

Estrogen sulfotransferase, testis isoform
type: ProteinReference
xref: Reference/UniProt P49891
organism: Mus musculus

NADH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADH

Reference/BioCyc ESTRONE-SULFATE
type: UnificationXref
id: ESTRONE-SULFATE
db: BioCyc

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/ChEBI CHEBI 17200
type: UnificationXref
id: CHEBI:17200
db: ChEBI

Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/UniProt Q9EQ06
type: UnificationXref
id: Q9EQ06
db: UniProt

Hydrogen Ion
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Hydrogen Ion

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Estrone sulfate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001425
xref: Reference/KEGG Compound C02538
xref: Reference/ChemSpider 2272513
xref: Reference/BioCyc ESTRONE-SULFATE
xref: Reference/PubChem-compound 3001028
xref: Reference/CAS 481-97-0
xref: Reference/ChEBI CHEBI 17474
chemical formula: C18H22O5S
molecular weight: 350.1188
structure: ChemicalStructure/PW C001101

Reference/ChEBI CHEBI 1189
type: UnificationXref
id: CHEBI:1189
db: ChEBI

Reference/CAS 566-76-7
type: UnificationXref
id: 566-76-7
db: CAS

Compound/PW C000100 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Estriol
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Estrogen sulfotransferase
type: Complex
component stoichiometry: Protein/14140 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Estrogen sulfotransferase, testis isoform

Reference/KEGG Compound C00468
type: UnificationXref
id: C00468
db: KEGG Compound

Reference/BioCyc ADENOSYL-HOMO-CYS
type: UnificationXref
id: ADENOSYL-HOMO-CYS
db: BioCyc

Reference/BioCyc UDP-GLUCURONATE
type: UnificationXref
id: UDP-GLUCURONATE
db: BioCyc

Unknown
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Unknown

Reference/PubChem-compound 6031
type: UnificationXref
id: 6031
db: PubChem-compound

Reference/CAS 485-80-3
type: UnificationXref
id: 485-80-3
db: CAS

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Estriol
type: SmallMolecule
cellular location: Cytosol
entity reference: Estriol

Unknown
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Unknown

ChemicalStructure/PW C000201
type: ChemicalStructure
structure format: SMILES

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

Reference/BioCyc 3-5-ADP
type: UnificationXref
id: 3-5-ADP
db: BioCyc

Reference/HMDB HMDB0004483
type: UnificationXref
id: HMDB0004483
db: HMDB

Reference/HMDB HMDB0004482
type: UnificationXref
id: HMDB0004482
db: HMDB

Mus musculus
type: BioSource
xref: Reference/TAXONOMY 10090

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H29N7O17P3
molecular weight: 744.08325
structure: ChemicalStructure/PW C000143

Adenosine 3',5'-diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine 3',5'-diphosphate

Uridine diphosphate glucuronic acid
type: SmallMoleculeReference
xref: Reference/BioCyc UDP-GLUCURONATE
xref: Reference/CAS 2616-64-0
xref: Reference/PubChem-compound 17473
xref: Reference/HMDB HMDB0000935
xref: Reference/ChEBI CHEBI 17200
xref: Reference/ChemSpider 16522
xref: Reference/KEGG Compound C00167
chemical formula: C15H22N2O18P2
molecular weight: 580.0343
structure: ChemicalStructure/PW C000746

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Reference/CAS 1053-73-2
type: UnificationXref
id: 1053-73-2
db: CAS

Compound/PW C000146 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Reference/KEGG Compound C02538
type: UnificationXref
id: C02538
db: KEGG Compound

ChemicalStructure/PW C000921
type: ChemicalStructure
structure format: SMILES

Reference/CAS 979-92-0
type: UnificationXref
id: 979-92-0
db: CAS

Reference/ChEBI CHEBI 17263
type: UnificationXref
id: CHEBI:17263
db: ChEBI

2-Hydroxyestrone
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: 2-Hydroxyestrone

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Unknown
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Unknown

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

ChemicalStructure/PW C000005
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 440624
type: UnificationXref
id: 440624
db: PubChem-compound

Reference/PubChem-compound 3001028
type: UnificationXref
id: 3001028
db: PubChem-compound

Reference/PubChem-compound 440623
type: UnificationXref
id: 440623
db: PubChem-compound

Compound/PW C001144 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Estrogen sulfotransferase, testis isoform
type: Protein
cellular location: Cytosol
entity reference: Estrogen sulfotransferase, testis isoform

S-Adenosylhomocysteine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 25246222
xref: Reference/ChemSpider 388301
xref: Reference/BioCyc ADENOSYL-HOMO-CYS
xref: Reference/CAS 979-92-0
xref: Reference/KEGG Compound C00021
xref: Reference/ChEBI CHEBI 16680
xref: Reference/HMDB HMDB0000939
chemical formula: C14H20N6O5S
molecular weight: 384.12158
structure: ChemicalStructure/PW C000749

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Reference/HMDB HMDB0001425
type: UnificationXref
id: HMDB0001425
db: HMDB

Reference/HMDB HMDB0000335
type: UnificationXref
id: HMDB0000335
db: HMDB

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

ChemicalStructure/PW C001101
type: ChemicalStructure
structure format: SMILES

Compound/PW C001144 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Protein/7781 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 1.0

NADH
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: NADH

Unknown
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Unknown

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Oxygen
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Oxygen

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/ChEBI CHEBI 15414
type: UnificationXref
id: CHEBI:15414
db: ChEBI

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/CAS 50-28-2
type: UnificationXref
id: 50-28-2
db: CAS

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/ChemSpider 9799
type: UnificationXref
id: 9799
db: ChemSpider

Estrone glucuronide
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Estrone glucuronide

Compound/PW C000721 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

NADPH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADPH

Reference/HMDB HMDB0000343
type: UnificationXref
id: HMDB0000343
db: HMDB

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

2-Methoxyestrone 3-glucuronide
type: SmallMoleculeReference
xref: Reference/CAS 25577-70-2
xref: Reference/PubChem-compound 22833612
xref: Reference/ChemSpider 17216256
xref: Reference/HMDB HMDB0004482
xref: Reference/KEGG Compound C11132
xref: Reference/BioCyc ESTRONE-SULFATE
chemical formula: C24H32O8
molecular weight: 448.20972
structure: ChemicalStructure/PW C002142

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

ReactionCatalysis99980
type: Catalysis
controller: Estrogen sulfotransferase
controlled: 2.8.2.4
control type: ACTIVATION

Estrone glucuronide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 115255
xref: Reference/ChemSpider 103124
xref: Reference/HMDB HMDB0004483
xref: Reference/KEGG Compound C11133
xref: Reference/BioCyc ESTRONE-SULFATE
xref: Reference/ChEBI CHEBI 28919
xref: Reference/CAS 2479-90-5
chemical formula: C24H30O8
molecular weight: 446.19406
structure: ChemicalStructure/PW C002143

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 159296
type: UnificationXref
id: 159296
db: PubChem-compound

Reference/PubChem-compound 17473
type: UnificationXref
id: 17473
db: PubChem-compound

Reference/KEGG Compound C05141
type: UnificationXref
id: C05141
db: KEGG Compound

Reference/KEGG Compound C11133
type: UnificationXref
id: C11133
db: KEGG Compound

Reference/KEGG Compound C11132
type: UnificationXref
id: C11132
db: KEGG Compound

Estradiol
type: SmallMolecule
cellular location: Cytosol
entity reference: Estradiol

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Reference/KEGG Compound C00019
type: UnificationXref
id: C00019
db: KEGG Compound

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H28N7O14P2
molecular weight: 664.11694
structure: ChemicalStructure/PW C000721

Protein/14140 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Estrogen sulfotransferase, testis isoform
stoichiometric coefficient: 2.0

Reference/BioCyc S-ADENOSYLMETHIONINE
type: UnificationXref
id: S-ADENOSYLMETHIONINE
db: BioCyc

Compound/PW C000005 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Methoxyestrone
stoichiometric coefficient: 1.0

Protein/7736 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Reference/KEGG Compound C00015
type: UnificationXref
id: C00015
db: KEGG Compound

Reference/ChemSpider 5660
type: UnificationXref
id: 5660
db: ChemSpider

Reference/ChEBI CHEBI 27974
type: UnificationXref
id: CHEBI:27974
db: ChEBI

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Compound/PW C000244 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Hydroxyestrone
stoichiometric coefficient: 1.0

Compound/PW C000143 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Reference/ChemSpider 389514
type: UnificationXref
id: 389514
db: ChemSpider

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/CAS 50-27-1
type: UnificationXref
id: 50-27-1
db: CAS

Reference/ChemSpider 388301
type: UnificationXref
id: 388301
db: ChemSpider

Reference/ChemSpider 389515
type: UnificationXref
id: 389515
db: ChemSpider

Compound/PW C000094 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Estrone
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00021
type: UnificationXref
id: C00021
db: KEGG Compound

ChemicalStructure/PW C000237
type: ChemicalStructure
structure format: SMILES

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Compound/PW C000237 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 16a-Hydroxyestrone
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000244
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 1156
type: UnificationXref
id: CHEBI:1156
db: ChEBI

Reference/CAS 482-67-7
type: UnificationXref
id: 482-67-7
db: CAS

NADP
type: SmallMolecule
cellular location: Cytosol
entity reference: NADP

Reference/ChEBI CHEBI 17985
type: UnificationXref
id: CHEBI:17985
db: ChEBI

Estradiol
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Estradiol

Endoplasmic Reticulum Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005789

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 103012
type: UnificationXref
id: 103012
db: ChemSpider

Reference/KEGG Compound C00951
type: UnificationXref
id: C00951
db: KEGG Compound

Reference/ChEBI CHEBI 17980
type: UnificationXref
id: CHEBI:17980
db: ChEBI

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Reference/CAS 362-08-3
type: UnificationXref
id: 362-08-3
db: CAS

Reference/BioCyc UDP
type: UnificationXref
id: UDP
db: BioCyc

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C05299
type: UnificationXref
id: C05299
db: KEGG Compound

Protein/7782 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 1.0

Reference/KEGG Compound C05298
type: UnificationXref
id: C05298
db: KEGG Compound

2.4.1.17
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000201 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000746 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002143 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000094 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Estrone glucuronide
right: Uridine 5'-diphosphate
spontaneous: false
EC number: 2.4.1.17
left: Uridine diphosphate glucuronic acid
left: Estrone
name: Estrone + Uridine diphosphate glucuronic acid → Estrone glucuronide + Uridine 5'-diphosphate
conversion direction: LEFT_TO_RIGHT

1.1.1.62
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000094 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000098 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
right: NADP
right: Estradiol
spontaneous: false
EC number: 1.1.1.62
left: Hydrogen Ion
left: Estrone
left: NADPH
name: Estrone + Hydrogen Ion + NADPH ↔ Estradiol + NADP
conversion direction: REVERSIBLE

Reaction110744
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000100 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000098 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Water
right: Estriol
right: NADP
spontaneous: false
left: Oxygen
left: Estradiol
left: NADPH
left: Hydrogen Ion
name: Estradiol + Hydrogen Ion + NADPH + Oxygen → Estriol + NADP + Water
conversion direction: LEFT_TO_RIGHT

Reaction110742
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000094 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000237 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Water
right: 16a-Hydroxyestrone
right: NADP
spontaneous: false
left: Oxygen
left: NADPH
left: Estrone
left: Hydrogen Ion
name: Estrone + Hydrogen Ion + NADPH + Oxygen → 16a-Hydroxyestrone + NADP + Water
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0000010
type: UnificationXref
id: HMDB0000010
db: HMDB

Reaction110743
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000237 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000100 Cytosol/Stoichiometry/1.0
right: Estriol
right: NAD
spontaneous: false
left: Hydrogen Ion
left: NADH
left: 16a-Hydroxyestrone
name: 16a-Hydroxyestrone + Hydrogen Ion + NADH ↔ Estriol + NAD
conversion direction: REVERSIBLE

Estrone Metabolism
type: Pathway
pathway order: PathwayEnzymeReaction/2111927
pathway order: PathwayEnzymeReaction/2111929
pathway order: PathwayEnzymeReaction/2111928
pathway order: PathwayEnzymeReaction/2111930
pathway order: PathwayEnzymeReaction/2111932
pathway order: PathwayEnzymeReaction/2111931
pathway order: PathwayEnzymeReaction/2111934
pathway order: PathwayEnzymeReaction/2111933
pathway order: PathwayEnzymeReaction/2111935
pathway component: Reaction110737
pathway component: Reaction110738
pathway component: 2.8.2.4
pathway component: 2.4.1.17
pathway component: ReactionCatalysis101073
pathway component: ReactionCatalysis101072
pathway component: ReactionCatalysis101071
pathway component: ReactionCatalysis99980
pathway component: ReactionCatalysis101078
pathway component: ReactionCatalysis101077
pathway component: ReactionCatalysis101076
pathway component: ReactionCatalysis101075
pathway component: ReactionCatalysis101074
pathway component: 1.1.1.62
pathway component: Reaction110744
pathway component: Reaction110742
pathway component: Reaction110743
xref: Reference/PathWhiz PW064678
xref: Reference/SMPDB SMP0063696
organism: Mus musculus

Reference/ChemSpider 103124
type: UnificationXref
id: 103124
db: ChemSpider

Reference/ChemSpider 5553
type: UnificationXref
id: 5553
db: ChemSpider

Reference/HMDB HMDB0000935
type: UnificationXref
id: HMDB0000935
db: HMDB

Reference/ChemSpider 5554
type: UnificationXref
id: 5554
db: ChemSpider

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

S-Adenosylmethionine
type: SmallMolecule
cellular location: Cytosol
entity reference: S-Adenosylmethionine

Reference/CAS 2479-90-5
type: UnificationXref
id: 2479-90-5
db: CAS

Reference/HMDB HMDB0000939
type: UnificationXref
id: HMDB0000939
db: HMDB

Reference/KEGG Compound C00167
type: UnificationXref
id: C00167
db: KEGG Compound

Reference/HMDB HMDB0000145
type: UnificationXref
id: HMDB0000145
db: HMDB

Compound/PW C000098 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Estradiol
stoichiometric coefficient: 1.0

Compound/PW C000244 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Hydroxyestrone
stoichiometric coefficient: 1.0

NAD
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: NAD

Uridine 5'-diphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17659
xref: Reference/PubChem-compound 6031
xref: Reference/CAS 58-98-0
xref: Reference/HMDB HMDB0000295
xref: Reference/KEGG Compound C00015
xref: Reference/ChemSpider 5809
xref: Reference/BioCyc UDP
chemical formula: C9H14N2O12P2
molecular weight: 404.0022
structure: ChemicalStructure/PW C000201

2-Methoxyestrone 3-glucuronide
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: 2-Methoxyestrone 3-glucuronide

Phosphoadenosine phosphosulfate
type: SmallMoleculeReference
xref: Reference/BioCyc PAPS
xref: Reference/HMDB HMDB0001134
xref: Reference/CAS 482-67-7
xref: Reference/ChemSpider 9799
xref: Reference/KEGG Compound C00053
xref: Reference/PubChem-compound 10214
xref: Reference/ChEBI CHEBI 17980
chemical formula: C10H15N5O13P2S
molecular weight: 506.98624
structure: ChemicalStructure/PW C000886

Compound/PW C002143 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Estrone glucuronide
stoichiometric coefficient: 1.0

Reference/ChemSpider 140102
type: UnificationXref
id: 140102
db: ChemSpider

Reference/BioCyc CPD-352
type: UnificationXref
id: CPD-352
db: BioCyc

Reference/BioCyc ESTRONE
type: UnificationXref
id: ESTRONE
db: BioCyc

Reference/KEGG Compound C00054
type: UnificationXref
id: C00054
db: KEGG Compound

Reference/KEGG Compound C00053
type: UnificationXref
id: C00053
db: KEGG Compound

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Compound/PW C002142 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Methoxyestrone 3-glucuronide
stoichiometric coefficient: 1.0

Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Estrone
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000145
xref: Reference/PubChem-compound 5870
xref: Reference/KEGG Compound C00468
xref: Reference/CAS 53-16-7
xref: Reference/ChEBI CHEBI 17263
xref: Reference/BioCyc ESTRONE
xref: Reference/ChemSpider 5660
chemical formula: C18H22O2
molecular weight: 270.162
structure: ChemicalStructure/PW C000094

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Water
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Water

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Reference/GENE ONTOLOGY GO 0005789
type: UnificationXref
id: GO:0005789
db: GENE ONTOLOGY

Estradiol
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 16469
xref: Reference/CAS 50-28-2
xref: Reference/BioCyc CPD-352
xref: Reference/PubChem-compound 5757
xref: Reference/ChemSpider 5554
xref: Reference/KEGG Compound C00951
xref: Reference/HMDB HMDB0000151
chemical formula: C18H24O2
molecular weight: 272.17764
structure: ChemicalStructure/PW C000098

Reference/ChemSpider 16522
type: UnificationXref
id: 16522
db: ChemSpider

Reference/HMDB HMDB0000151
type: UnificationXref
id: HMDB0000151
db: HMDB

Reference/HMDB HMDB0000153
type: UnificationXref
id: HMDB0000153
db: HMDB

Reaction110737
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000721 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000244 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000094 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Water
right: NAD
right: 2-Hydroxyestrone
spontaneous: false
left: NADH
left: Oxygen
left: Estrone
left: Hydrogen Ion
name: Estrone + Hydrogen Ion + NADH + Oxygen → 2-Hydroxyestrone + NAD + Water
conversion direction: LEFT_TO_RIGHT

Reaction110738
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000749 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000244 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000005 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921 Cytosol/Stoichiometry/1.0
right: S-Adenosylhomocysteine
right: 2-Methoxyestrone
spontaneous: false
left: 2-Hydroxyestrone
left: S-Adenosylmethionine
name: 2-Hydroxyestrone + S-Adenosylmethionine → 2-Methoxyestrone + S-Adenosylhomocysteine
conversion direction: LEFT_TO_RIGHT

NAD
type: SmallMolecule
cellular location: Cytosol
entity reference: NAD

2.4.1.17
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000201 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000746 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000005 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002142 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Uridine 5'-diphosphate
right: 2-Methoxyestrone 3-glucuronide
spontaneous: false
EC number: 2.4.1.17
left: Uridine diphosphate glucuronic acid
left: 2-Methoxyestrone
name: 2-Methoxyestrone + Uridine diphosphate glucuronic acid → 2-Methoxyestrone 3-glucuronide + Uridine 5'-diphosphate
conversion direction: LEFT_TO_RIGHT

Unknown
type: ProteinReference
organism: Mus musculus

Estriol
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Estriol

Reference/PubChem-compound 10214
type: UnificationXref
id: 10214
db: PubChem-compound

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Reference/PathWhiz PW064678
type: UnificationXref
id: PW064678
db: PathWhiz

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Compound/PW C000094 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Estrone
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001134
type: UnificationXref
id: HMDB0001134
db: HMDB

ChemicalStructure/PW C000043
type: ChemicalStructure
structure format: SMILES

S-Adenosylhomocysteine
type: SmallMolecule
cellular location: Cytosol
entity reference: S-Adenosylhomocysteine

Reference/PubChem-compound 115255
type: UnificationXref
id: 115255
db: PubChem-compound

Compound/PW C000746 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine diphosphate glucuronic acid
stoichiometric coefficient: 1.0

Compound/PW C000043 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine 3',5'-diphosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChemSpider 31983
type: UnificationXref
id: 31983
db: ChemSpider

2-Methoxyestrone
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: 2-Methoxyestrone

Compound/PW C000721 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/CAS 53-16-7
type: UnificationXref
id: 53-16-7
db: CAS

Unknown
type: ProteinReference
organism: Mus musculus

Reference/CAS 58-98-0
type: UnificationXref
id: 58-98-0
db: CAS

Unknown
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Unknown

ChemicalStructure/PW C000886
type: ChemicalStructure
structure format: SMILES

Reference/CAS 362-06-1
type: UnificationXref
id: 362-06-1
db: CAS

Compound/PW C040034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Compound/PW C000098 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Estradiol
stoichiometric coefficient: 1.0

Reference/BioCyc PAPS
type: UnificationXref
id: PAPS
db: BioCyc

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Compound/PW C000201 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine 5'-diphosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000098
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Reference/PubChem-compound 22833612
type: UnificationXref
id: 22833612
db: PubChem-compound

Compound/PW C000100 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Estriol
stoichiometric coefficient: 1.0

Reference/ChemSpider 17216256
type: UnificationXref
id: 17216256
db: ChemSpider

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/HMDB HMDB0000295
type: UnificationXref
id: HMDB0000295
db: HMDB

ChemicalStructure/PW C000094
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 5809
type: UnificationXref
id: 5809
db: ChemSpider

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

2-Methoxyestrone
type: SmallMolecule
cellular location: Cytosol
entity reference: 2-Methoxyestrone

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/ChEBI CHEBI 16469
type: UnificationXref
id: CHEBI:16469
db: ChEBI

16a-Hydroxyestrone
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000335
xref: Reference/PubChem-compound 115116
xref: Reference/CAS 566-76-7
xref: Reference/ChEBI CHEBI 776
xref: Reference/ChemSpider 103012
xref: Reference/KEGG Compound C05300
chemical formula: C18H22O3
molecular weight: 286.1569
structure: ChemicalStructure/PW C000237

Estrone
type: SmallMolecule
cellular location: Cytosol
entity reference: Estrone

Reference/ChemSpider 2272513
type: UnificationXref
id: 2272513
db: ChemSpider

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Reference/ChEBI CHEBI 776
type: UnificationXref
id: CHEBI:776
db: ChEBI

16a-Hydroxyestrone
type: SmallMolecule
cellular location: Cytosol
entity reference: 16a-Hydroxyestrone

Compound/PW C000237 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 16a-Hydroxyestrone
stoichiometric coefficient: 1.0

Reference/PubChem-compound 115116
type: UnificationXref
id: 115116
db: PubChem-compound

2-Hydroxyestrone
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000343
xref: Reference/ChemSpider 389514
xref: Reference/KEGG Compound C05298
xref: Reference/ChEBI CHEBI 1156
xref: Reference/CAS 362-06-1
xref: Reference/PubChem-compound 440623
chemical formula: C18H22O3
molecular weight: 286.1569
structure: ChemicalStructure/PW C000244

16a-Hydroxyestrone
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: 16a-Hydroxyestrone

Reference/HMDB HMDB0000061
type: UnificationXref
id: HMDB0000061
db: HMDB

Transmembrane O-methyltransferase homolog
type: ProteinReference
xref: Reference/UniProt A1Y9I9
organism: Mus musculus

Reference/SMPDB SMP0063696
type: UnificationXref
id: SMP0063696
db: SMPDB

Reference/CAS 481-97-0
type: UnificationXref
id: 481-97-0
db: CAS

Estrone
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Estrone

ChemicalStructure/PW C000749
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C05300
type: UnificationXref
id: C05300
db: KEGG Compound

ChemicalStructure/PW C000746
type: ChemicalStructure
structure format: SMILES

Reference/CAS 25577-70-2
type: UnificationXref
id: 25577-70-2
db: CAS

Reference/PubChem-compound 25246222
type: UnificationXref
id: 25246222
db: PubChem-compound

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Estrone sulfate
type: SmallMolecule
cellular location: Cytosol
entity reference: Estrone sulfate

Uridine 5'-diphosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Uridine 5'-diphosphate

Unknown
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Unknown

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

NADP
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: NADP

2.8.2.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000094 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000043 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001101 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000886 Cytosol/Stoichiometry/1.0
right: Adenosine 3',5'-diphosphate
right: Estrone sulfate
spontaneous: false
EC number: 2.8.2.4
left: Phosphoadenosine phosphosulfate
left: Estrone
name: Estrone + Phosphoadenosine phosphosulfate → Adenosine 3',5'-diphosphate + Estrone sulfate
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Reference/ChEBI CHEBI 17659
type: UnificationXref
id: CHEBI:17659
db: ChEBI

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Compound/PW C000005 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Methoxyestrone
stoichiometric coefficient: 1.0

Estradiol 17-beta-dehydrogenase 11
type: ProteinReference
xref: Reference/UniProt Q9EQ06
organism: Mus musculus

ReactionCatalysis101073
type: Catalysis
controller: UDP-glucuronosyltransferase 1-1
controlled: 2.4.1.17
control type: ACTIVATION

ReactionCatalysis101072
type: Catalysis
controller: Transmembrane O-methyltransferase homolog
controlled: Reaction110738
control type: ACTIVATION

ReactionCatalysis101071
type: Catalysis
controller: Unknown
controlled: Reaction110737
control type: ACTIVATION

Reference/ChEBI CHEBI 16680
type: UnificationXref
id: CHEBI:16680
db: ChEBI

Reference/UniProt P49891
type: UnificationXref
id: P49891
db: UniProt

Reference/PubChem-compound 24762165
type: UnificationXref
id: 24762165
db: PubChem-compound

ReactionCatalysis101078
type: Catalysis
controller: Unknown
controlled: Reaction110744
control type: ACTIVATION

ChemicalStructure/PW C002142
type: ChemicalStructure
structure format: SMILES

ReactionCatalysis101077
type: Catalysis
controller: Estradiol 17-beta-dehydrogenase 11
controlled: Reaction110743
control type: ACTIVATION

ChemicalStructure/PW C002143
type: ChemicalStructure
structure format: SMILES

ReactionCatalysis101076
type: Catalysis
controller: Unknown
controlled: Reaction110742
control type: ACTIVATION

Phosphoadenosine phosphosulfate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphoadenosine phosphosulfate

ReactionCatalysis101075
type: Catalysis
controller: Estradiol 17-beta-dehydrogenase 11
controlled: 1.1.1.62
control type: ACTIVATION

ReactionCatalysis101074
type: Catalysis
controller: UDP-glucuronosyltransferase 1-1
controlled: 2.4.1.17
control type: ACTIVATION

Estriol
type: SmallMoleculeReference
xref: Reference/CAS 50-27-1
xref: Reference/ChEBI CHEBI 27974
xref: Reference/KEGG Compound C05141
xref: Reference/PubChem-compound 5756
xref: Reference/ChemSpider 5553
xref: Reference/HMDB HMDB0000153
chemical formula: C18H24O3
molecular weight: 288.17255
structure: ChemicalStructure/PW C000100

Compound/PW C000886 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoadenosine phosphosulfate
stoichiometric coefficient: 1.0

Reference/UniProt A1Y9I9
type: UnificationXref
id: A1Y9I9
db: UniProt