Rho-associated protein kinase 1
type: Complex
component stoichiometry: Protein/1350 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Rho-associated protein kinase 1

Gβ
type: ProteinReference
xref: Reference/UniProt P62873
organism: Homo sapiens

Interaction333
type: MolecularInteraction
interaction type: direct_interaction
name: Guanosine triphosphate + Gαi/o inhibits Adenylyl cyclase
participant: Guanosine triphosphate_Gαi/o
participant: Adenylyl cyclase

Interaction214
type: MolecularInteraction
interaction type: direct_interaction
name: Ras activates RAF
participant: Ras
participant: RAF

Interaction335
type: MolecularInteraction
interaction type: direct_interaction
name: Guanosine triphosphate + Gαi/o activates PI3K
participant: Guanosine triphosphate_Gαi/o
participant: PI3K

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Interaction334
type: MolecularInteraction
interaction type: direct_interaction
name: Guanosine triphosphate + Gαi/o activates Ras
participant: Ras
participant: Guanosine triphosphate_Gαi/o

Interaction216
type: MolecularInteraction
interaction type: direct_interaction
name: MEK activates MAPK
participant: MAPK
participant: MEK

Interaction337
type: MolecularInteraction
interaction type: direct_interaction
name: RAC-alpha serine/threonine-protein kinase activates NF-κB
participant: NF-κB
participant: RAC-alpha serine/threonine-protein kinase

Inositol 1,4,5-trisphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Inositol 1,4,5-trisphosphate

Interaction215
type: MolecularInteraction
interaction type: direct_interaction
name: RAF activates MEK
participant: RAF
participant: MEK

Interaction336
type: MolecularInteraction
interaction type: direct_interaction
name: PI3K activates RAC-alpha serine/threonine-protein kinase
participant: PI3K
participant: RAC-alpha serine/threonine-protein kinase

Interaction339
type: MolecularInteraction
interaction type: direct_interaction
name: Guanosine triphosphate + Gα12/13 activates Rho
participant: Rho
participant: Guanosine triphosphate_Gα12/13

Interaction338
type: MolecularInteraction
interaction type: direct_interaction
name: PI3K activates Rac
participant: Rac
participant: PI3K

Ras
type: ProteinReference
organism: Homo sapiens

RAF
type: ProteinReference
organism: Homo sapiens

MEK
type: Protein
cellular location: Cytoplasm
entity reference: MEK

direct_interaction
type: InteractionVocabulary

Compound/PW C000986 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine triphosphate
stoichiometric coefficient: 1.0

MEK
type: ProteinReference
organism: Homo sapiens

MAPK
type: ProteinReference
organism: Homo sapiens

Serum response factor
type: ProteinReference
xref: Reference/UniProt P11831
organism: Homo sapiens

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Guanosine triphosphate_Gαq/11
type: Complex
component stoichiometry: Protein/Generic351 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Compound/PW C000986 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Gαq/11
component: Guanosine triphosphate

Lysophosphatidic acid_Lysophosphatidic acid receptor 5 (Homo sapiens)
type: Complex
component stoichiometry: Compound/Generic348 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/2554 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Lysophosphatidic acid
component: Lysophosphatidic acid receptor 5

Interaction340
type: MolecularInteraction
interaction type: direct_interaction
name: Rho activates Serum response factor
participant: Rho
participant: Serum response factor

Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
type: ProteinReference
xref: Reference/UniProt Q5JWF2
organism: Homo sapiens

Interaction342
type: MolecularInteraction
interaction type: direct_interaction
name: Guanosine triphosphate + Gαq/11 activates PLC
participant: Guanosine triphosphate_Gαq/11
participant: PLC

Interaction341
type: MolecularInteraction
interaction type: direct_interaction
name: Rho activates Rho-associated protein kinase 1
participant: Rho-associated protein kinase 1
participant: Rho

Interaction344
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium activates PKC
participant: Calcium
participant: PKC

Interaction343
type: MolecularInteraction
interaction type: direct_interaction
name: 1,2-diacyl-sn-glycerol activates PKC
participant: 1,2-diacyl-sn-glycerol
participant: PKC

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Interaction346
type: MolecularInteraction
interaction type: direct_interaction
name: Rho-associated protein kinase 1 activates NF-κB
participant: NF-κB
participant: Rho-associated protein kinase 1

MAPK
type: Protein
cellular location: Cytoplasm
entity reference: MAPK

Interaction345
type: MolecularInteraction
interaction type: direct_interaction
name: PKC activates NF-κB
participant: NF-κB
participant: PKC

Reference/KEGG Compound C00681
type: UnificationXref
id: C00681
db: KEGG Compound

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Interaction349
type: MolecularInteraction
interaction type: direct_interaction
name: Gαs activates Adenylyl cyclase
participant: Adenylyl cyclase
participant: Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas

Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

BoundComplex/29 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine triphosphate_Gα
stoichiometric coefficient: 1.0

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

TransportCatalysis922
type: Catalysis
controller: Inositol 1,4,5-trisphosphate receptor type 1
controlled: Transport1035
control type: ACTIVATION

cAMP
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6076
xref: Reference/HMDB HMDB0000058
xref: Reference/ChEBI CHEBI 17489
xref: Reference/CAS 60-92-4
xref: Reference/BioCyc CAMP
xref: Reference/ChemSpider 5851
xref: Reference/KEGG Compound C00575
chemical formula: C10H12N5O6P
molecular weight: 329.05252
structure: ChemicalStructure/PW C000041

Reference/UniProt P59768
type: UnificationXref
id: P59768
db: UniProt

Gαq/11
type: Protein
cellular location: Cell Membrane
entity reference: Gαq/11

Compound/PW C000041 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

Interaction352
type: MolecularInteraction
interaction type: direct_interaction
name: Lysophosphatidic acid activates Gα + Guanosine diphosphate + Gβγ (Homo sapiens) + Lysophosphatidic acid receptor 5 (Homo sapiens)
participant: Gα_Guanosine diphosphate_Gβγ (Homo sapiens)_Lysophosphatidic acid receptor 5 (Homo sapiens)
participant: Lysophosphatidic acid

Reference/PathWhiz PW000048
type: UnificationXref
id: PW000048
db: PathWhiz

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Gγ
type: Protein
cellular location: Cell Membrane
entity reference: Gγ

Reference/KEGG Compound C00575
type: UnificationXref
id: C00575
db: KEGG Compound

Reference/ChEBI CHEBI 16595
type: UnificationXref
id: CHEBI:16595
db: ChEBI

Reference/UniProt Q9NQ66
type: UnificationXref
id: Q9NQ66
db: UniProt

ProteinComplex/6637 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Gβγ
stoichiometric coefficient: 1.0

Reference/CAS 85166-31-0
type: UnificationXref
id: 85166-31-0
db: CAS

Guanosine triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Guanosine triphosphate

Reference/UniProt P11831
type: UnificationXref
id: P11831
db: UniProt

Interaction242
type: MolecularInteraction
interaction type: direct_interaction
name: Inositol 1,4,5-trisphosphate activates Inositol 1,4,5-trisphosphate receptor type 1
participant: Inositol 1,4,5-trisphosphate receptor type 1
participant: Inositol 1,4,5-trisphosphate

Inositol 1,4,5-trisphosphate receptor type 1
type: Protein
entity reference: Inositol 1,4,5-trisphosphate receptor type 1

Lysophosphatidic acid receptor 5
type: ProteinReference
xref: Reference/UniProt Q9H1C0
organism: Homo sapiens

Reference/ChemSpider 5851
type: UnificationXref
id: 5851
db: ChemSpider

Protein/Generic349 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Gα
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6830
type: UnificationXref
id: 6830
db: PubChem-compound

Lysophosphatidic acid
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Lysophosphatidic acid

Serum response factor
type: Protein
cellular location: Nucleus
entity reference: Serum response factor

Guanosine diphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001201
xref: Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
xref: Reference/CAS 146-91-8
xref: Reference/PubChem-compound 8977
xref: Reference/ChEBI CHEBI 17552
xref: Reference/ChemSpider 8630
xref: Reference/KEGG Compound C00035
chemical formula: C10H15N5O11P2
molecular weight: 443.02432
structure: ChemicalStructure/PW C000936

Rho
type: Protein
cellular location: Nucleus
entity reference: Rho

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Reference/SMPDB SMP0063757
type: UnificationXref
id: SMP0063757
db: SMPDB

Guanosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15996
xref: Reference/ChemSpider 6569
xref: Reference/KEGG Compound C00044
xref: Reference/PubChem-compound 6830
xref: Reference/HMDB HMDB0001273
xref: Reference/CAS 86-01-1
xref: Reference/BioCyc GTP
chemical formula: C10H16N5O14P3
molecular weight: 522.99066
structure: ChemicalStructure/PW C000986

Gα_Guanosine diphosphate_Gβγ (Homo sapiens)_Lysophosphatidic acid receptor 5 (Homo sapiens)
type: Complex
component stoichiometry: ProteinComplex/6637 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Compound/PW C000936 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/2554 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/Generic349 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Guanosine diphosphate
component: Lysophosphatidic acid receptor 5
component: Gα
component: Gβγ

Guanosine triphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Guanosine triphosphate

RAC-alpha serine/threonine-protein kinase
type: Protein
cellular location: Nucleus
entity reference: RAC-alpha serine/threonine-protein kinase

Gγ
type: ProteinReference
xref: Reference/UniProt P59768
organism: Homo sapiens

Rho-associated protein kinase 1
type: ProteinReference
xref: Reference/UniProt Q13464
organism: Homo sapiens

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Compound/Generic344 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: phosphatidylinositol 4,5-bisphosphate
stoichiometric coefficient: 1.0

Reference/BioCyc inositol 1,4,5-trisphosphate
type: UnificationXref
id: inositol_1,4,5-trisphosphate
db: BioCyc

1,2-diacyl-sn-glycerol
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00641

Lysophosphatidic acid
type: SmallMolecule
entity reference: Lysophosphatidic acid
name: SubPathwayOutput

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

ChemicalStructure/PW C000936
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/ChemSpider 388562
type: UnificationXref
id: 388562
db: ChemSpider

RAC-alpha serine/threonine-protein kinase
type: Protein
cellular location: Cytoplasm
entity reference: RAC-alpha serine/threonine-protein kinase

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

Guanosine triphosphate_Gα
type: Complex
component stoichiometry: Protein/Generic349 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Compound/PW C000986 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Guanosine triphosphate
component: Gα

Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
type: UnificationXref
id: GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
db: BioCyc

1,2-diacyl-sn-glycerol
type: SmallMolecule
cellular location: Cell Membrane
entity reference: 1,2-diacyl-sn-glycerol

Rho
type: Protein
cellular location: Cytoplasm
entity reference: Rho

Gαi/o
type: Protein
cellular location: Cytoplasm
entity reference: Gαi/o

Reference/GENE ONTOLOGY GO 0005634
type: UnificationXref
id: GO:0005634
db: GENE ONTOLOGY

Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
type: Protein
cellular location: Cell Membrane
entity reference: Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas

4.6.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000041 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
right: cAMP
right: Pyrophosphate
spontaneous: false
EC number: 4.6.1.1
left: Adenosine triphosphate
name: Adenosine triphosphate → Pyrophosphate + cAMP
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 17489
type: UnificationXref
id: CHEBI:17489
db: ChEBI

Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/BioCyc CAMP
type: UnificationXref
id: CAMP
db: BioCyc

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine triphosphate

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Reference/HMDB HMDB0001201
type: UnificationXref
id: HMDB0001201
db: HMDB

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: O7P2
molecular weight: 173.91193
structure: ChemicalStructure/PW C000170

Reference/UniProt Q08828
type: UnificationXref
id: Q08828
db: UniProt

Rac
type: Protein
cellular location: Cytoplasm
entity reference: Rac

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

Gα
type: Protein
cellular location: Cell Membrane
entity reference: Gα

Reference/ChEBI CHEBI 15996
type: UnificationXref
id: CHEBI:15996
db: ChEBI

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/UniProt P31749
type: UnificationXref
id: P31749
db: UniProt

Protein/Generic351 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Gαq/11
stoichiometric coefficient: 1.0

Inositol 1,4,5-trisphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001498
xref: Reference/PubChem-compound 439456
xref: Reference/CAS 85166-31-0
xref: Reference/BioCyc inositol 1,4,5-trisphosphate
xref: Reference/KEGG Compound C01245
xref: Reference/ChEBI CHEBI 16595
xref: Reference/ChemSpider 388562
chemical formula: C6H15O15P3
molecular weight: 419.96237
structure: ChemicalStructure/PW C001155

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Reference/CAS 60-92-4
type: UnificationXref
id: 60-92-4
db: CAS

PKC
type: Protein
cellular location: Nucleus
entity reference: PKC

Reaction110773
type: BiochemicalReaction
participant stoichiometry: BoundComplex/29 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/6637 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: BoundComplex/40 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: BoundComplex/41 Cell Membrane/Stoichiometry/1.0
right: Lysophosphatidic acid_Lysophosphatidic acid receptor 5 (Homo sapiens)
right: Guanosine triphosphate_Gα
right: Gβγ
spontaneous: false
left: Gα_Guanosine diphosphate_Gβγ (Homo sapiens)_Lysophosphatidic acid receptor 5 (Homo sapiens)
name: Gα + Guanosine diphosphate + Gβγ (Homo sapiens) + Lysophosphatidic acid receptor 5 (Homo sapiens) → Guanosine triphosphate + Gα + Gβγ + Lysophosphatidic acid + Lysophosphatidic acid receptor 5 (Homo sapiens)
conversion direction: LEFT_TO_RIGHT

Phospholipid Biosynthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway57761
pathway component: SubPathwayInteraction57761
xref: Reference/PathWhiz PW000048
xref: Reference/SMPDB SMP0000025
name: SubPathway

cAMP
type: SmallMolecule
cellular location: Cytoplasm
entity reference: cAMP

Guanosine diphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Guanosine diphosphate

Reference/UniProt Q14643
type: UnificationXref
id: Q14643
db: UniProt

Inositol 1,4,5-trisphosphate receptor type 1
type: Complex
component stoichiometry: Protein/2126 Endoplasmic Reticulum Membrane/Stoichiometry/4.0
cellular location: Endoplasmic Reticulum Membrane
component: Inositol 1,4,5-trisphosphate receptor type 1

Reference/KEGG Compound C04637
type: UnificationXref
id: C04637
db: KEGG Compound

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: Reference/UniProt Q14643

Endoplasmic Reticulum
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005783

Endoplasmic Reticulum Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005789

Protein/1350 Nucleus/Stoichiometry/2.0
type: Stoichiometry
physical entity: Rho-associated protein kinase 1
stoichiometric coefficient: 2.0

Reference/UniProt Q9H1C0
type: UnificationXref
id: Q9H1C0
db: UniProt

RAF
type: Protein
cellular location: Cytoplasm
entity reference: RAF

Reference/KEGG Compound C01245
type: UnificationXref
id: C01245
db: KEGG Compound

Reference/KEGG Compound C00035
type: UnificationXref
id: C00035
db: KEGG Compound

1,2-diacyl-sn-glycerol
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 1,2-diacyl-sn-glycerol

Inositol 1,4,5-trisphosphate receptor type 1
type: Complex
component stoichiometry: Protein/2126/Stoichiometry/4.0
component: Inositol 1,4,5-trisphosphate receptor type 1

Calcium
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Calcium

Reference/UniProt Q5JWF2
type: UnificationXref
id: Q5JWF2
db: UniProt

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])(=O)OP([O-])([O-])=O

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

PI3K
type: Protein
cellular location: Cytoplasm
entity reference: PI3K

ReactionCatalysis101095
type: Catalysis
controller: Adenylate cyclase type 1
controlled: 4.6.1.1
control type: ACTIVATION

Reference/KEGG Compound C00044
type: UnificationXref
id: C00044
db: KEGG Compound

Water
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Water

ChemicalStructure/PW C001155
type: ChemicalStructure
structure format: SMILES

Ras
type: Protein
cellular location: Cytoplasm
entity reference: Ras

Rho-associated protein kinase 1
type: Protein
cellular location: Cytoplasm
entity reference: Rho-associated protein kinase 1

Adenylate cyclase type 1
type: ProteinReference
xref: Reference/UniProt Q08828
organism: Homo sapiens

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: Reference/UniProt P31749
organism: Homo sapiens

Protein/2126/Stoichiometry/4.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate receptor type 1
stoichiometric coefficient: 4.0

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Protein/Generic350 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Gαi/o
stoichiometric coefficient: 1.0

Compound/PW C000986 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine triphosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Inositol 1,4,5-trisphosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Inositol 1,4,5-trisphosphate

Reaction100922
type: BiochemicalReaction
participant stoichiometry: Compound/Generic295 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001155 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic344 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
right: 1,2-diacyl-sn-glycerol
right: Inositol 1,4,5-trisphosphate
spontaneous: false
left: Water
left: phosphatidylinositol 4,5-bisphosphate
name: Water + phosphatidylinositol 4,5-bisphosphate → 1,2-diacyl-sn-glycerol + Inositol 1,4,5-trisphosphate
conversion direction: LEFT_TO_RIGHT

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

BoundComplex/41 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lysophosphatidic acid_Lysophosphatidic acid receptor 5 (Homo sapiens)
stoichiometric coefficient: 1.0

Guanosine triphosphate_Gαi/o
type: Complex
component stoichiometry: Compound/PW C000986 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/Generic350 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Gαi/o
component: Guanosine triphosphate

Reference/PubChem-compound 439456
type: UnificationXref
id: 439456
db: PubChem-compound

Reference/GENE ONTOLOGY GO 0005789
type: UnificationXref
id: GO:0005789
db: GENE ONTOLOGY

Protein/Generic352 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Gα12/13
stoichiometric coefficient: 1.0

Inositol 1,4,5-trisphosphate receptor type 1
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Inositol 1,4,5-trisphosphate receptor type 1

Reference/SMPDB SMP0000025
type: UnificationXref
id: SMP0000025
db: SMPDB

Reference/GENE ONTOLOGY GO 0005783
type: UnificationXref
id: GO:0005783
db: GENE ONTOLOGY

Gα12/13
type: Protein
cellular location: Cytoplasm
entity reference: Gα12/13

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

BoundComplex/40 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Gα_Guanosine diphosphate_Gβγ (Homo sapiens)_Lysophosphatidic acid receptor 5 (Homo sapiens)
stoichiometric coefficient: 1.0

Reference/PubChem-compound 8977
type: UnificationXref
id: 8977
db: PubChem-compound

Adenylate cyclase type 1
type: Protein
cellular location: Cytoplasm
entity reference: Adenylate cyclase type 1

ReactionCatalysis91035
type: Catalysis
controller: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
controlled: Reaction100922
control type: ACTIVATION

Pyrophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pyrophosphate

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: Reference/UniProt Q9NQ66
organism: Homo sapiens

Reference/HMDB HMDB0001498
type: UnificationXref
id: HMDB0001498
db: HMDB

ChemicalStructure/PW C000041
type: ChemicalStructure
structure format: SMILES

Compound/PW C001155 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate
stoichiometric coefficient: 1.0

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

SubPathwayInteraction57761
type: Interaction
name: SubPathway57761Reaction
name: SubPathwayReaction
participant: Lysophosphatidic acid

Reference/UniProt P62873
type: UnificationXref
id: P62873
db: UniProt

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

PLC
type: Protein
cellular location: Cell Membrane
entity reference: PLC

Reference/ChemSpider 8630
type: UnificationXref
id: 8630
db: ChemSpider

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Rho-associated protein kinase 1
type: Protein
cellular location: Nucleus
entity reference: Rho-associated protein kinase 1

Adenylyl cyclase
type: Protein
cellular location: Cell Membrane
entity reference: Adenylyl cyclase

Reference/HMDB HMDB0000058
type: UnificationXref
id: HMDB0000058
db: HMDB

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Lysophosphatidic Acid LPA5 Signalling
type: Pathway
pathway order: PathwayEnzymeReaction/1191453
pathway order: PathwayInteraction/346
pathway order: PathwayEnzymeReaction/1191476
pathway order: PathwayInteraction/349
pathway order: PathwayEnzymeReaction/1191452
pathway order: PathwayInteraction/340
pathway order: PathwayInteraction/341
pathway order: PathwayInteraction/242
pathway order: PathwayTransport/1191455
pathway order: PathwayInteraction/342
pathway order: PathwayInteraction/343
pathway order: PathwayInteraction/344
pathway order: PathwayInteraction/345
pathway order: PathwayInteraction/214
pathway order: PathwayInteraction/335
pathway order: PathwayInteraction/215
pathway order: PathwayInteraction/336
pathway order: PathwayInteraction/216
pathway order: PathwayInteraction/337
pathway order: PathwayInteraction/338
pathway order: PathwayInteraction/339
pathway order: PathwayInteraction/352
pathway order: PathwayInteraction/333
pathway order: PathwaySubPathway/57761
pathway order: PathwayInteraction/334
pathway component: Transport1035
pathway component: 4.6.1.1
pathway component: Interaction352
pathway component: Interaction333
pathway component: Interaction214
pathway component: Interaction335
pathway component: Interaction334
pathway component: Interaction216
pathway component: Interaction337
pathway component: Reaction100922
pathway component: Interaction215
pathway component: Interaction336
pathway component: Interaction339
pathway component: Interaction338
pathway component: Interaction340
pathway component: Interaction342
pathway component: Interaction341
pathway component: Interaction242
pathway component: Interaction344
pathway component: Interaction343
pathway component: ReactionCatalysis101095
pathway component: Interaction346
pathway component: Interaction345
pathway component: Interaction349
pathway component: ReactionCatalysis91035
pathway component: TransportCatalysis922
pathway component: Reaction110773
pathway component: Phospholipid Biosynthesis
xref: Reference/PathWhiz PW064747
xref: Reference/SMPDB SMP0063757
organism: Homo sapiens

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChemSpider 6569
type: UnificationXref
id: 6569
db: ChemSpider

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Protein/1350 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Rho-associated protein kinase 1
stoichiometric coefficient: 2.0

Protein/2554 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lysophosphatidic acid receptor 5
stoichiometric coefficient: 1.0

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Reference/ChEBI CHEBI 17552
type: UnificationXref
id: CHEBI:17552
db: ChEBI

Reference/BioCyc GTP
type: UnificationXref
id: GTP
db: BioCyc

Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00641
type: UnificationXref
id: C00641
db: KEGG Compound

Reference/HMDB HMDB0001273
type: UnificationXref
id: HMDB0001273
db: HMDB

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: Protein
cellular location: Cell Membrane
entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

Transport1035
type: Transport
participant stoichiometry: Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Endoplasmic Reticulum/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Cell, Endoplasmic Reticulum to Homo sapiens, Cell, Cytoplasm
conversion direction: LEFT_TO_RIGHT

Protein/2126 Endoplasmic Reticulum Membrane/Stoichiometry/4.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate receptor type 1
stoichiometric coefficient: 4.0

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Rho-associated protein kinase 1
type: Complex
component stoichiometry: Protein/1350 Nucleus/Stoichiometry/2.0
cellular location: Nucleus
component: Rho-associated protein kinase 1

PI3K
type: ProteinReference
organism: Homo sapiens

ChemicalStructure/PW C000986
type: ChemicalStructure
structure format: SMILES

NF-κB
type: ProteinReference
organism: Homo sapiens

Rac
type: ProteinReference
organism: Homo sapiens

Rho
type: ProteinReference
organism: Homo sapiens

PLC
type: ProteinReference
organism: Homo sapiens

Adenylyl cyclase
type: Protein
cellular location: Cytoplasm
entity reference: Adenylyl cyclase

PKC
type: ProteinReference
organism: Homo sapiens

Gβγ
type: Complex
cellular location: Cell Membrane
component: Gβ
component: Gγ

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

NF-κB
type: Protein
cellular location: Nucleus
entity reference: NF-κB

Reference/PathWhiz PW064747
type: UnificationXref
id: PW064747
db: PathWhiz

phosphatidylinositol 4,5-bisphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: phosphatidylinositol 4,5-bisphosphate

Reference/CAS 86-01-1
type: UnificationXref
id: 86-01-1
db: CAS

Nucleus
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005634

Reference/UniProt Q13464
type: UnificationXref
id: Q13464
db: UniProt

Reference/PubChem-compound 6076
type: UnificationXref
id: 6076
db: PubChem-compound

Compound/Generic295 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1,2-diacyl-sn-glycerol
stoichiometric coefficient: 1.0

Calcium
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Calcium

Gβ
type: Protein
cellular location: Cell Membrane
entity reference: Gβ

Lysophosphatidic acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00681

Guanosine triphosphate_Gα12/13
type: Complex
component stoichiometry: Compound/PW C000986 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/Generic352 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Gα12/13
component: Guanosine triphosphate

PKC
type: Protein
cellular location: Cytoplasm
entity reference: PKC

Lysophosphatidic acid receptor 5
type: Protein
cellular location: Cell Membrane
entity reference: Lysophosphatidic acid receptor 5

Compound/PW C000353 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Gα
type: ProteinReference
organism: Homo sapiens

Gαi/o
type: ProteinReference
organism: Homo sapiens

Gαq/11
type: ProteinReference
organism: Homo sapiens

Compound/PW C000936 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine diphosphate
stoichiometric coefficient: 1.0

Gα12/13
type: ProteinReference
organism: Homo sapiens

Reference/CAS 146-91-8
type: UnificationXref
id: 146-91-8
db: CAS

Adenylyl cyclase
type: ProteinReference
organism: Homo sapiens

Compound/Generic348 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lysophosphatidic acid
stoichiometric coefficient: 1.0

Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

phosphatidylinositol 4,5-bisphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C04637