Arachidonic acid
type: SmallMoleculeReference
xref: Reference/CAS 506-32-1
xref: Reference/BioCyc ARACHIDONIC ACID
xref: Reference/ChEBI CHEBI 15843
xref: Reference/KEGG Compound C00219
xref: Reference/HMDB HMDB0001043
xref: Reference/ChemSpider 392692
xref: Reference/PubChem-compound 444899
chemical formula: C20H32O2
molecular weight: 304.24023
structure: ChemicalStructure/PW C000821

Reference/ChEBI CHEBI 15843
type: UnificationXref
id: CHEBI:15843
db: ChEBI

cAMP-dependent protein kinase catalytic subunit alpha
type: Protein
cellular location: Nucleus
entity reference: cAMP-dependent protein kinase catalytic subunit alpha

Reference/UniProt Q13393
type: UnificationXref
id: Q13393
db: UniProt

Interaction696
type: MolecularInteraction
interaction type: direct_interaction
name: cAMP-dependent protein kinase catalytic subunit alpha activates Cyclic AMP-dependent transcription factor ATF-4 (Homo sapiens) + Phosphate
participant: cAMP-dependent protein kinase catalytic subunit alpha
participant: Cyclic AMP-dependent transcription factor ATF-4 (Homo sapiens)_Phosphate

Dual specificity mitogen-activated protein kinase kinase 7
type: ProteinReference
xref: Reference/UniProt O14733
organism: Homo sapiens

Interaction577
type: MolecularInteraction
interaction type: direct_interaction
name: Phospholipase D1 activates Phosphatidic Acid
participant: Phospholipase D1
participant: Phosphatidic Acid

Interaction698
type: MolecularInteraction
interaction type: direct_interaction
name: Cyclic AMP-dependent transcription factor ATF-4 (Homo sapiens) + Phosphate activates Lutropin subunit beta
participant: Lutropin subunit beta
participant: Cyclic AMP-dependent transcription factor ATF-4 (Homo sapiens)_Phosphate

Epidermal growth factor receptor
type: Complex
component stoichiometry: Protein/1351 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Epidermal growth factor receptor

Interaction576
type: MolecularInteraction
interaction type: direct_interaction
name: Cytosolic phospholipase A2 beta activates Arachidonic acid
participant: Cytosolic phospholipase A2 beta
participant: Arachidonic acid

Interaction697
type: MolecularInteraction
interaction type: direct_interaction
name: Cyclic AMP-dependent transcription factor ATF-4 (Homo sapiens) + Phosphate activates Follitropin subunit beta
participant: Cyclic AMP-dependent transcription factor ATF-4 (Homo sapiens)_Phosphate
participant: Follitropin subunit beta

Interaction579
type: MolecularInteraction
interaction type: direct_interaction
name: Cell division control protein 42 homolog activates Mitogen-activated protein kinase kinase kinase 1
participant: Cell division control protein 42 homolog
participant: Mitogen-activated protein kinase kinase kinase 1

Protein kinase C alpha type
type: Protein
cellular location: Cytoplasm
entity reference: Protein kinase C alpha type

Interaction578
type: MolecularInteraction
interaction type: direct_interaction
name: Proto-oncogene tyrosine-protein kinase Src activates Cell division control protein 42 homolog
participant: Proto-oncogene tyrosine-protein kinase Src
participant: Cell division control protein 42 homolog

Interaction699
type: MolecularInteraction
interaction type: direct_interaction
name: Cyclic AMP-dependent transcription factor ATF-4 (Homo sapiens) + Phosphate activates Glycoprotein hormones alpha chain
participant: Glycoprotein hormones alpha chain
participant: Cyclic AMP-dependent transcription factor ATF-4 (Homo sapiens)_Phosphate

Reference/UniProt P28482
type: UnificationXref
id: P28482
db: UniProt

Protein/9551 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Leucine-rich repeat-containing protein 7
stoichiometric coefficient: 1.0

direct_interaction
type: InteractionVocabulary

Matrix metalloproteinase-14
type: Protein
cellular location: Extracellular Space
entity reference: Matrix metalloproteinase-14

Dual specificity mitogen-activated protein kinase kinase 1
type: Protein
cellular location: Cytoplasm
entity reference: Dual specificity mitogen-activated protein kinase kinase 1

Reference/UniProt P0C869
type: UnificationXref
id: P0C869
db: UniProt

Protein/1845 Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit alpha-1C
stoichiometric coefficient: 1.0

Cyclic AMP-dependent transcription factor ATF-4 (Homo sapiens)_Phosphate
type: Complex
component stoichiometry: Protein/3334 Nucleus/Stoichiometry/1.0
component stoichiometry: Compound/PW C001104 Nucleus/Stoichiometry/1.0
cellular location: Nucleus
component: Phosphate
component: Cyclic AMP-dependent transcription factor ATF-4

Mitogen-activated protein kinase 8
type: Protein
cellular location: Nucleus
entity reference: Mitogen-activated protein kinase 8

Reference/UniProt P04049
type: UnificationXref
id: P04049
db: UniProt

Protein kinase C alpha type
type: Protein
cellular location: Membrane
entity reference: Protein kinase C alpha type

Mitogen-activated protein kinase 14
type: Protein
cellular location: Cytoplasm
entity reference: Mitogen-activated protein kinase 14

Mitogen-activated protein kinase kinase kinase 1
type: Protein
cellular location: Cytoplasm
entity reference: Mitogen-activated protein kinase kinase kinase 1

Reference/UniProt P19419
type: UnificationXref
id: P19419
db: UniProt

Progonadoliberin-1
type: Protein
cellular location: Cell Membrane
entity reference: Progonadoliberin-1

Gonadotropin-releasing hormone receptor
type: Protein
cellular location: Cytoplasm
entity reference: Gonadotropin-releasing hormone receptor

Proheparin-binding EGF-like growth factor
type: Protein
cellular location: Extracellular Space
entity reference: Proheparin-binding EGF-like growth factor

Protein/1783 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Transcription factor AP-1
stoichiometric coefficient: 1.0

Phosphate_Mitogen-activated protein kinase 8 (Homo sapiens)
type: Complex
component stoichiometry: Compound/PW C001104 Nucleus/Stoichiometry/1.0
component stoichiometry: Protein/1424 Nucleus/Stoichiometry/1.0
cellular location: Nucleus
component: Mitogen-activated protein kinase 8
component: Phosphate

Voltage-depenent L-type calcium channel
type: Complex
component stoichiometry: Protein/2706 Membrane/Stoichiometry/1.0
component stoichiometry: Protein/1845 Membrane/Stoichiometry/1.0
component stoichiometry: Protein/2720 Membrane/Stoichiometry/1.0
cellular location: Membrane
component: Voltage-dependent L-type calcium channel subunit beta-1
component: Voltage-dependent L-type calcium channel subunit alpha-1C
component: Voltage-dependent calcium channel subunit alpha-2/delta-2

Reference/UniProt P01215
type: UnificationXref
id: P01215
db: UniProt

cAMP
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6076
xref: Reference/HMDB HMDB0000058
xref: Reference/ChEBI CHEBI 17489
xref: Reference/CAS 60-92-4
xref: Reference/BioCyc CAMP
xref: Reference/ChemSpider 5851
xref: Reference/KEGG Compound C00575
chemical formula: C10H12N5O6P
molecular weight: 329.05252
structure: ChemicalStructure/PW C000041

Protein kinase C alpha type
type: ProteinReference
xref: Reference/UniProt P17252
organism: Homo sapiens

Reference/KEGG Compound C00219
type: UnificationXref
id: C00219
db: KEGG Compound

Proheparin-binding EGF-like growth factor
type: Protein
cellular location: Membrane
entity reference: Proheparin-binding EGF-like growth factor

Cell division control protein 42 homolog
type: Protein
cellular location: Cytoplasm
entity reference: Cell division control protein 42 homolog

Cyclic AMP-dependent transcription factor ATF-4
type: Protein
cellular location: Nucleus
entity reference: Cyclic AMP-dependent transcription factor ATF-4

Reference/KEGG Compound C00575
type: UnificationXref
id: C00575
db: KEGG Compound

Protein kinase C beta type
type: Protein
cellular location: Membrane
entity reference: Protein kinase C beta type

Reference/UniProt Q9NQ66
type: UnificationXref
id: Q9NQ66
db: UniProt

Reference/UniProt Q13936
type: UnificationXref
id: Q13936
db: UniProt

Reference/UniProt P01225
type: UnificationXref
id: P01225
db: UniProt

Protein/14458 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: ETS domain-containing protein Elk-1
stoichiometric coefficient: 1.0

GnRH Signaling Pathway
type: Pathway
pathway order: PathwayInteraction/566
pathway order: PathwayInteraction/720
pathway order: PathwayInteraction/567
pathway order: PathwayInteraction/721
pathway order: PathwayInteraction/700
pathway order: PathwayInteraction/547
pathway order: PathwayInteraction/701
pathway order: PathwayInteraction/548
pathway order: PathwayInteraction/702
pathway order: PathwayInteraction/549
pathway order: PathwayInteraction/703
pathway order: PathwayInteraction/705
pathway order: PathwayInteraction/707
pathway order: PathwayInteraction/709
pathway order: PathwayInteraction/560
pathway order: PathwayInteraction/561
pathway order: PathwayInteraction/562
pathway order: PathwayInteraction/563
pathway order: PathwayInteraction/564
pathway order: PathwayInteraction/565
pathway order: PathwayInteraction/555
pathway order: PathwayInteraction/533
pathway order: PathwayInteraction/577
pathway order: PathwayInteraction/698
pathway order: PathwayInteraction/556
pathway order: PathwayInteraction/578
pathway order: PathwayInteraction/699
pathway order: PathwayInteraction/557
pathway order: PathwayInteraction/579
pathway order: PathwayTransport/1192855
pathway order: PathwayInteraction/558
pathway order: PathwayInteraction/712
pathway order: PathwayInteraction/559
pathway order: PathwayInteraction/713
pathway order: PathwayInteraction/714
pathway order: PathwayInteraction/715
pathway order: PathwayInteraction/716
pathway order: PathwayInteraction/718
pathway order: PathwayInteraction/719
pathway order: PathwayInteraction/550
pathway order: PathwayInteraction/551
pathway order: PathwayInteraction/553
pathway order: PathwayInteraction/696
pathway order: PathwayInteraction/554
pathway order: PathwayInteraction/576
pathway order: PathwayInteraction/697
pathway component: Interaction551
pathway component: Interaction550
pathway component: Interaction553
pathway component: Interaction696
pathway component: Interaction555
pathway component: Interaction533
pathway component: Interaction577
pathway component: Interaction698
pathway component: Interaction554
pathway component: Interaction576
pathway component: Interaction697
pathway component: Interaction557
pathway component: Interaction579
pathway component: Interaction556
pathway component: Interaction578
pathway component: Interaction699
pathway component: Interaction559
pathway component: Interaction713
pathway component: Interaction558
pathway component: Interaction712
pathway component: Interaction715
pathway component: Interaction714
pathway component: Interaction716
pathway component: Interaction719
pathway component: Interaction718
pathway component: Interaction560
pathway component: Interaction562
pathway component: Interaction561
pathway component: Interaction564
pathway component: Transport1187
pathway component: Interaction563
pathway component: Interaction566
pathway component: Interaction720

Reference/UniProt P01229
type: UnificationXref
id: P01229
db: UniProt

Reference/UniProt P50281
type: UnificationXref
id: P50281
db: UniProt

Reference/UniProt P01112
type: UnificationXref
id: P01112
db: UniProt

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: O4P
molecular weight: 94.95342
structure: ChemicalStructure/PW C001104

Protein/2706 Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent calcium channel subunit alpha-2/delta-2
stoichiometric coefficient: 1.0

Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens)_Phosphate
type: Complex
component stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/5788 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Dual specificity mitogen-activated protein kinase kinase 1
component: Phosphate

Reference/ChemSpider 5851
type: UnificationXref
id: 5851
db: ChemSpider

BiologicalState217
type: BioSource
xref: Reference/TAXONOMY 4932
name: Saccharomyces cerevisiae

Reference/UniProt O43707
type: UnificationXref
id: O43707
db: UniProt

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Glycoprotein hormones alpha chain
type: Protein
cellular location: Nucleus
entity reference: Glycoprotein hormones alpha chain

Reference/UniProt Q8TD86
type: UnificationXref
id: Q8TD86
db: UniProt

Mitogen-activated protein kinase 1
type: Protein
cellular location: Cytoplasm
entity reference: Mitogen-activated protein kinase 1

Reference/UniProt P17252
type: UnificationXref
id: P17252
db: UniProt

Reference/UniProt Q16539
type: UnificationXref
id: Q16539
db: UniProt

Protein/8730 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Early growth response protein 1
stoichiometric coefficient: 1.0

Protein/1424 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mitogen-activated protein kinase 8
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase 1
type: ProteinReference
xref: Reference/UniProt P28482
organism: Homo sapiens

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: Protein
cellular location: Membrane
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-2

Growth factor receptor-bound protein 2
type: ProteinReference
xref: Reference/UniProt P62993
organism: Homo sapiens

Epidermal growth factor receptor
type: ProteinReference
xref: Reference/UniProt P00533
organism: Homo sapiens

DG
type: SmallMoleculeReference

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])([O-])=O

Voltage-dependent L-type calcium channel subunit alpha-1F
type: Protein
cellular location: Membrane
entity reference: Voltage-dependent L-type calcium channel subunit alpha-1F

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Phospholipase D1
type: ProteinReference
xref: Reference/UniProt Q13393
organism: Homo sapiens

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

ETS domain-containing protein Elk-1
type: ProteinReference
xref: Reference/UniProt P19419
organism: Homo sapiens

Phosphate_Mitogen-activated protein kinase 1 (Homo sapiens)
type: Complex
component stoichiometry: Compound/PW C001104 Nucleus/Stoichiometry/1.0
component stoichiometry: Protein/1117 Nucleus/Stoichiometry/1.0
cellular location: Nucleus
component: Mitogen-activated protein kinase 1
component: Phosphate

Protein/9229 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Alpha-actinin-4
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Interaction700
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase kinase kinase 2 activates Dual specificity mitogen-activated protein kinase kinase 3 (Homo sapiens) + Phosphate
participant: Mitogen-activated protein kinase kinase kinase 2
participant: Dual specificity mitogen-activated protein kinase kinase 3 (Homo sapiens)_Phosphate

Interaction702
type: MolecularInteraction
interaction type: direct_interaction
name: Protein kinase C complex activates RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens) + Phosphate
participant: Protein kinase C complex
participant: RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens)_Phosphate

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Interaction701
type: MolecularInteraction
interaction type: direct_interaction
name: Dual specificity mitogen-activated protein kinase kinase 3 (Homo sapiens) + Phosphate activates Mitogen-activated protein kinase 14 (Homo sapiens) + Phosphate
participant: Dual specificity mitogen-activated protein kinase kinase 3 (Homo sapiens)_Phosphate
participant: Mitogen-activated protein kinase 14 (Homo sapiens)_Phosphate

Reference/UniProt Q9NY47
type: UnificationXref
id: Q9NY47
db: UniProt

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/UniProt Q07889
type: UnificationXref
id: Q07889
db: UniProt

Interaction703
type: MolecularInteraction
interaction type: direct_interaction
name: GTPase HRas activates RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens) + Phosphate
participant: GTPase HRas
participant: RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens)_Phosphate

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: Protein
cellular location: Cytoplasm
entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

Reference/UniProt O60840
type: UnificationXref
id: O60840
db: UniProt

Interaction705
type: MolecularInteraction
interaction type: direct_interaction
name: RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens) + Phosphate activates Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens) + Phosphate
participant: Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens)_Phosphate
participant: RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens)_Phosphate

Interaction707
type: MolecularInteraction
interaction type: direct_interaction
name: Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens) + Phosphate activates Phosphate + Mitogen-activated protein kinase 1 (Homo sapiens)
participant: Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens)_Phosphate
participant: Phosphate_Mitogen-activated protein kinase 1 (Homo sapiens)

Phosphate_Early growth response protein 1 (Homo sapiens)_ELK1 (Homo sapiens)
type: Complex
component stoichiometry: Protein/8730 Nucleus/Stoichiometry/1.0
component stoichiometry: Compound/PW C001104 Nucleus/Stoichiometry/1.0
component stoichiometry: Protein/14458 Nucleus/Stoichiometry/1.0
cellular location: Nucleus
component: ETS domain-containing protein Elk-1
component: Early growth response protein 1
component: Phosphate

Interaction709
type: MolecularInteraction
interaction type: direct_interaction
name: Phosphate + Mitogen-activated protein kinase 1 (Homo sapiens) activates Phosphate + Early growth response protein 1 (Homo sapiens) + ELK1 (Homo sapiens)
participant: Phosphate_Mitogen-activated protein kinase 1 (Homo sapiens)
participant: Phosphate_Early growth response protein 1 (Homo sapiens)_ELK1 (Homo sapiens)

Growth factor receptor-bound protein 2
type: Protein
cellular location: Cytoplasm
entity reference: Growth factor receptor-bound protein 2

Reference/GENE ONTOLOGY GO 0005634
type: UnificationXref
id: GO:0005634
db: GENE ONTOLOGY

Reference/PathWhiz PW064816
type: UnificationXref
id: PW064816
db: PathWhiz

Follitropin subunit beta
type: Protein
cellular location: Nucleus
entity reference: Follitropin subunit beta

Son of sevenless homolog 1
type: Protein
cellular location: Cytoplasm
entity reference: Son of sevenless homolog 1

Epidermal growth factor receptor
type: Complex
component stoichiometry: Protein/1351 Membrane/Stoichiometry/2.0
cellular location: Membrane
component: Epidermal growth factor receptor

Reference/UniProt Q9Y2U5
type: UnificationXref
id: Q9Y2U5
db: UniProt

Gonadotropin-releasing hormone receptor
type: Protein
cellular location: Cell Membrane
entity reference: Gonadotropin-releasing hormone receptor

Reference/ChEBI CHEBI 17489
type: UnificationXref
id: CHEBI:17489
db: ChEBI

Son of sevenless homolog 1
type: ProteinReference
xref: Reference/UniProt Q07889
organism: Homo sapiens

Reference/UniProt P60953
type: UnificationXref
id: P60953
db: UniProt

Reference/BioCyc CAMP
type: UnificationXref
id: CAMP
db: BioCyc

72 kDa type IV collagenase
type: ProteinReference
xref: Reference/UniProt P08253
organism: Homo sapiens

Protein kinase C complex
type: Complex
cellular location: Membrane
component: Protein kinase C beta type
component: Protein kinase C alpha type

Reference/UniProt Q01668
type: UnificationXref
id: Q01668
db: UniProt

Protein/1405 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mitogen-activated protein kinase 14
stoichiometric coefficient: 1.0

Phosphate_Transcription factor AP-1 (Homo sapiens)
type: Complex
component stoichiometry: Compound/PW C001104 Nucleus/Stoichiometry/1.0
component stoichiometry: Protein/1783 Nucleus/Stoichiometry/1.0
cellular location: Nucleus
component: Phosphate
component: Transcription factor AP-1

Transcription factor AP-1
type: Protein
cellular location: Nucleus
entity reference: Transcription factor AP-1

Interaction713
type: MolecularInteraction
interaction type: direct_interaction
name: Phosphate + Early growth response protein 1 (Homo sapiens) + ELK1 (Homo sapiens) activates Glycoprotein hormones alpha chain
participant: Phosphate_Early growth response protein 1 (Homo sapiens)_ELK1 (Homo sapiens)
participant: Glycoprotein hormones alpha chain

Interaction712
type: MolecularInteraction
interaction type: direct_interaction
name: Phosphate + Early growth response protein 1 (Homo sapiens) + ELK1 (Homo sapiens) activates Lutropin subunit beta
participant: Phosphate_Early growth response protein 1 (Homo sapiens)_ELK1 (Homo sapiens)
participant: Lutropin subunit beta

Reference/PubChem-compound 444899
type: UnificationXref
id: 444899
db: PubChem-compound

Interaction715
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase kinase kinase 1 activates Phosphate + Dual specificity mitogen-activated protein kinase kinase 7 (Homo sapiens)
participant: Phosphate_Dual specificity mitogen-activated protein kinase kinase 7 (Homo sapiens)
participant: Mitogen-activated protein kinase kinase kinase 1

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Interaction714
type: MolecularInteraction
interaction type: direct_interaction
name: Phosphate + Early growth response protein 1 (Homo sapiens) + ELK1 (Homo sapiens) activates Follitropin subunit beta
participant: Phosphate_Early growth response protein 1 (Homo sapiens)_ELK1 (Homo sapiens)
participant: Follitropin subunit beta

Voltage-dependent L-type calcium channel subunit alpha-1D
type: Protein
cellular location: Cytoplasm
entity reference: Voltage-dependent L-type calcium channel subunit alpha-1D

Reference/UniProt Q96NW7
type: UnificationXref
id: Q96NW7
db: UniProt

Interaction716
type: MolecularInteraction
interaction type: direct_interaction
name: Phosphate + Dual specificity mitogen-activated protein kinase kinase 7 (Homo sapiens) activates Phosphate + Mitogen-activated protein kinase 8 (Homo sapiens)
participant: Phosphate_Dual specificity mitogen-activated protein kinase kinase 7 (Homo sapiens)
participant: Phosphate_Mitogen-activated protein kinase 8 (Homo sapiens)

Reference/UniProt Q08828
type: UnificationXref
id: Q08828
db: UniProt

Interaction719
type: MolecularInteraction
interaction type: direct_interaction
name: Phosphate + Transcription factor AP-1 (Homo sapiens) activates Lutropin subunit beta
participant: Lutropin subunit beta
participant: Phosphate_Transcription factor AP-1 (Homo sapiens)

Reference/UniProt Q02750
type: UnificationXref
id: Q02750
db: UniProt

Interaction718
type: MolecularInteraction
interaction type: direct_interaction
name: Phosphate + Mitogen-activated protein kinase 8 (Homo sapiens) activates Phosphate + Transcription factor AP-1 (Homo sapiens)
participant: Phosphate_Mitogen-activated protein kinase 8 (Homo sapiens)
participant: Phosphate_Transcription factor AP-1 (Homo sapiens)

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

Protein/3977 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dual specificity mitogen-activated protein kinase kinase 7
stoichiometric coefficient: 1.0

Protein/1084 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: RAF proto-oncogene serine/threonine-protein kinase
stoichiometric coefficient: 1.0

Calmodulin-like protein 6
type: Protein
cellular location: Cytoplasm
entity reference: Calmodulin-like protein 6

RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens)_Phosphate
type: Complex
component stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/1084 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: RAF proto-oncogene serine/threonine-protein kinase
component: Phosphate

DG
type: SmallMolecule
cellular location: Cytoplasm
entity reference: DG

GTPase HRas
type: ProteinReference
xref: Reference/UniProt P01112
organism: Homo sapiens

Interaction720
type: MolecularInteraction
interaction type: direct_interaction
name: Phosphate + Transcription factor AP-1 (Homo sapiens) activates Glycoprotein hormones alpha chain
participant: Glycoprotein hormones alpha chain
participant: Phosphate_Transcription factor AP-1 (Homo sapiens)

Interaction721
type: MolecularInteraction
interaction type: direct_interaction
name: Phosphate + Transcription factor AP-1 (Homo sapiens) activates Follitropin subunit beta
participant: Phosphate_Transcription factor AP-1 (Homo sapiens)
participant: Follitropin subunit beta

Calcium/calmodulin-dependent protein kinase type II subunit alpha
type: ProteinReference
xref: Reference/UniProt Q9UQM7
organism: Homo sapiens

Leucine-rich repeat-containing protein 7
type: ProteinReference
xref: Reference/UniProt Q96NW7
organism: Homo sapiens

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: Reference/UniProt P17612
organism: Homo sapiens

RAF proto-oncogene serine/threonine-protein kinase
type: Protein
cellular location: Cytoplasm
entity reference: RAF proto-oncogene serine/threonine-protein kinase

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Reference/CAS 60-92-4
type: UnificationXref
id: 60-92-4
db: CAS

Protein/1351 Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Epidermal growth factor receptor
stoichiometric coefficient: 2.0

Arachidonic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Arachidonic acid

Dual specificity mitogen-activated protein kinase kinase 7
type: Protein
cellular location: Cytoplasm
entity reference: Dual specificity mitogen-activated protein kinase kinase 7

cAMP
type: SmallMolecule
cellular location: Cytoplasm
entity reference: cAMP

Calmodulin-like protein 6
type: ProteinReference
xref: Reference/UniProt Q8TD86
organism: Homo sapiens

Cytosolic phospholipase A2 beta
type: Protein
cellular location: Cytoplasm
entity reference: Cytosolic phospholipase A2 beta

Gonadotropin-releasing hormone receptor
type: ProteinReference
xref: Reference/UniProt P30968
organism: Homo sapiens

Reference/UniProt Q14643
type: UnificationXref
id: Q14643
db: UniProt

Progonadoliberin-1
type: ProteinReference
xref: Reference/UniProt P01148
organism: Homo sapiens

Protein kinase C beta type
type: ProteinReference
xref: Reference/UniProt P05771
organism: Homo sapiens

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: Reference/UniProt Q14643
organism: Homo sapiens

Endoplasmic Reticulum
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005783

Dual specificity mitogen-activated protein kinase kinase 3 (Homo sapiens)_Phosphate
type: Complex
component stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/2078 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Dual specificity mitogen-activated protein kinase kinase 3
component: Phosphate

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Epidermal growth factor receptor
type: Protein
cellular location: Cytoplasm
entity reference: Epidermal growth factor receptor

Cyclic AMP-dependent transcription factor ATF-4
type: ProteinReference
xref: Reference/UniProt P18848
organism: Homo sapiens

Reference/UniProt P30968
type: UnificationXref
id: P30968
db: UniProt

Leucine-rich repeat-containing protein 7
type: Protein
cellular location: Cytoplasm
entity reference: Leucine-rich repeat-containing protein 7

Voltage-dependent L-type calcium channel subunit alpha-1S
type: Protein
cellular location: Cytoplasm
entity reference: Voltage-dependent L-type calcium channel subunit alpha-1S

72 kDa type IV collagenase
type: Protein
cellular location: Extracellular Space
entity reference: 72 kDa type IV collagenase

Epidermal growth factor receptor
type: Protein
cellular location: Membrane
entity reference: Epidermal growth factor receptor

Early growth response protein 1
type: Protein
cellular location: Nucleus
entity reference: Early growth response protein 1

Dual specificity mitogen-activated protein kinase kinase 7
type: Protein
cellular location: Nucleus
entity reference: Dual specificity mitogen-activated protein kinase kinase 7

Calcium
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Calcium

Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

IP3
type: SmallMoleculeReference

Phosphatidic Acid
type: SmallMoleculeReference

Reference/ChemSpider 392692
type: UnificationXref
id: 392692
db: ChemSpider

Voltage-dependent L-type calcium channel subunit alpha-1D
type: ProteinReference
xref: Reference/UniProt Q01668
organism: Homo sapiens

Reference/UniProt P05771
type: UnificationXref
id: P05771
db: UniProt

Voltage-dependent L-type calcium channel subunit alpha-1C
type: ProteinReference
xref: Reference/UniProt Q13936
organism: Homo sapiens

Cell division control protein 42 homolog
type: ProteinReference
xref: Reference/UniProt P60953
organism: Homo sapiens

Voltage-dependent L-type calcium channel subunit alpha-1S
type: Protein
cellular location: Membrane
entity reference: Voltage-dependent L-type calcium channel subunit alpha-1S

Reference/UniProt P05412
type: UnificationXref
id: P05412
db: UniProt

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
type: ProteinReference
xref: Reference/UniProt P63092
organism: Homo sapiens

Phosphate
type: SmallMolecule
cellular location: Nucleus
entity reference: Phosphate

Reference/UniProt P18848
type: UnificationXref
id: P18848
db: UniProt

Reference/UniProt Q02641
type: UnificationXref
id: Q02641
db: UniProt

Alpha-actinin-4
type: Protein
cellular location: Cytoplasm
entity reference: Alpha-actinin-4

Reference/UniProt Q9UQM7
type: UnificationXref
id: Q9UQM7
db: UniProt

Adenylate cyclase type 1
type: ProteinReference
xref: Reference/UniProt Q08828
organism: Homo sapiens

Reference/UniProt P63092
type: UnificationXref
id: P63092
db: UniProt

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Voltage-dependent L-type calcium channel subunit alpha-1D
type: Protein
cellular location: Membrane
entity reference: Voltage-dependent L-type calcium channel subunit alpha-1D

Reference/SMPDB SMP0063811
type: UnificationXref
id: SMP0063811
db: SMPDB

Protein/9550 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium/calmodulin-dependent protein kinase type II subunit alpha
stoichiometric coefficient: 1.0

Protein/5788 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dual specificity mitogen-activated protein kinase kinase 1
stoichiometric coefficient: 1.0

Reference/UniProt P29992
type: UnificationXref
id: P29992
db: UniProt

Phospholipase D1
type: Protein
cellular location: Cytoplasm
entity reference: Phospholipase D1

Voltage-dependent L-type calcium channel subunit alpha-1C
type: Protein
cellular location: Cytoplasm
entity reference: Voltage-dependent L-type calcium channel subunit alpha-1C

Lutropin subunit beta
type: ProteinReference
xref: Reference/UniProt P01229
organism: BiologicalState217

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Glycoprotein hormones alpha chain
type: ProteinReference
xref: Reference/UniProt P01215
organism: Homo sapiens

ChemicalStructure/PW C000821
type: ChemicalStructure
structure format: SMILES
structure data: CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O

Follitropin subunit beta
type: ProteinReference
xref: Reference/UniProt P01225
organism: Homo sapiens

Reference/UniProt P08253
type: UnificationXref
id: P08253
db: UniProt

Cytosolic phospholipase A2 beta
type: ProteinReference
xref: Reference/UniProt P0C869
organism: Homo sapiens

Guanine nucleotide-binding protein subunit alpha-11
type: Protein
cellular location: Cytoplasm
entity reference: Guanine nucleotide-binding protein subunit alpha-11

Phosphatidic Acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphatidic Acid

Reference/UniProt P46734
type: UnificationXref
id: P46734
db: UniProt

Reference/UniProt O14733
type: UnificationXref
id: O14733
db: UniProt

Reference/UniProt P00533
type: UnificationXref
id: P00533
db: UniProt

Reference/GENE ONTOLOGY GO 0005783
type: UnificationXref
id: GO:0005783
db: GENE ONTOLOGY

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: ProteinReference
xref: Reference/UniProt Q9NY47
organism: Homo sapiens

Voltage-dependent L-type calcium channel subunit alpha-1F
type: ProteinReference
xref: Reference/UniProt O60840
organism: Homo sapiens

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: Reference/UniProt P29992
organism: Homo sapiens

Transport1187
type: Transport
participant stoichiometry: Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Endoplasmic Reticulum/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (?) Transport: Homo sapiens, Cell, Endoplasmic Reticulum to Homo sapiens, Cell, Cytoplasm
conversion direction: LEFT_TO_RIGHT

Mitogen-activated protein kinase kinase kinase 1
type: ProteinReference
xref: Reference/UniProt Q13233
organism: Homo sapiens

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: Reference/UniProt Q02750
organism: Homo sapiens

Adenylate cyclase type 1
type: Protein
cellular location: Cytoplasm
entity reference: Adenylate cyclase type 1

Matrix metalloproteinase-14
type: ProteinReference
xref: Reference/UniProt P50281
organism: Homo sapiens

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: Reference/UniProt Q9NQ66
organism: Homo sapiens

Phosphate_Dual specificity mitogen-activated protein kinase kinase 7 (Homo sapiens)
type: Complex
component stoichiometry: Compound/PW C001104 Nucleus/Stoichiometry/1.0
component stoichiometry: Protein/3977 Nucleus/Stoichiometry/1.0
cellular location: Nucleus
component: Dual specificity mitogen-activated protein kinase kinase 7
component: Phosphate

Voltage-dependent L-type calcium channel
type: Complex
cellular location: Membrane
component: Voltage-dependent L-type calcium channel subunit alpha-1S
component: Voltage-dependent L-type calcium channel subunit alpha-1C
component: Voltage-dependent L-type calcium channel subunit alpha-1F
component: Voltage-dependent L-type calcium channel subunit alpha-1D

IP3
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: IP3

Reference/GENE ONTOLOGY GO 0016020
type: UnificationXref
id: GO:0016020
db: GENE ONTOLOGY

ChemicalStructure/PW C000041
type: ChemicalStructure
structure format: SMILES

Alpha-actinin-4
type: ProteinReference
xref: Reference/UniProt O43707
organism: Homo sapiens

Proto-oncogene tyrosine-protein kinase Src
type: Protein
cellular location: Cytoplasm
entity reference: Proto-oncogene tyrosine-protein kinase Src

Inositol 1,4,5-trisphosphate receptor type 1
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: Inositol 1,4,5-trisphosphate receptor type 1

Mitogen-activated protein kinase 14 (Homo sapiens)_Phosphate
type: Complex
component stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/1405 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Mitogen-activated protein kinase 14
component: Phosphate

Voltage-dependent L-type calcium channel subunit alpha-1S
type: ProteinReference
xref: Reference/UniProt Q13698
organism: Homo sapiens

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Voltage-dependent L-type calcium channel subunit alpha-1F
type: Protein
cellular location: Cytoplasm
entity reference: Voltage-dependent L-type calcium channel subunit alpha-1F

Reference/UniProt Q13233
type: UnificationXref
id: Q13233
db: UniProt

Reference/UniProt P12931
type: UnificationXref
id: P12931
db: UniProt

Voltage-dependent L-type calcium channel subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q02641
organism: Homo sapiens

Mitogen-activated protein kinase kinase kinase 2
type: Protein
cellular location: Cytoplasm
entity reference: Mitogen-activated protein kinase kinase kinase 2

Protein kinase C complex
type: Complex
cellular location: Cytoplasm
component: Protein kinase C beta type
component: Protein kinase C alpha type

Interaction533
type: MolecularInteraction
interaction type: direct_interaction
name: Growth factor receptor-bound protein 2 activates Son of sevenless homolog 1
participant: Growth factor receptor-bound protein 2
participant: Son of sevenless homolog 1

Proto-oncogene tyrosine-protein kinase Src
type: ProteinReference
xref: Reference/UniProt P12931
organism: Homo sapiens

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Reference/UniProt P62993
type: UnificationXref
id: P62993
db: UniProt

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Reference/UniProt P45983
type: UnificationXref
id: P45983
db: UniProt

Reference/HMDB HMDB0000058
type: UnificationXref
id: HMDB0000058
db: HMDB

ETS domain-containing protein Elk-1
type: Protein
cellular location: Nucleus
entity reference: ETS domain-containing protein Elk-1

cAMP-dependent protein kinase catalytic subunit alpha
type: Protein
cellular location: Cytoplasm
entity reference: cAMP-dependent protein kinase catalytic subunit alpha

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

Protein/1117 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mitogen-activated protein kinase 1
stoichiometric coefficient: 1.0

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Mitogen-activated protein kinase 14
type: ProteinReference
xref: Reference/UniProt Q16539
organism: Homo sapiens

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
type: Protein
cellular location: Cytoplasm
entity reference: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Interaction548
type: MolecularInteraction
interaction type: direct_interaction
name: Gonadotropin-releasing hormone receptor activates Guanine nucleotide-binding protein alpha
participant: Gonadotropin-releasing hormone receptor
participant: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
xref: Reference/UniProt P04049
organism: Homo sapiens

Interaction547
type: MolecularInteraction
interaction type: direct_interaction
name: Progonadoliberin-1 activates Gonadotropin-releasing hormone receptor
participant: Gonadotropin-releasing hormone receptor
participant: Progonadoliberin-1

Phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphate

Interaction549
type: MolecularInteraction
interaction type: direct_interaction
name: Guanine nucleotide-binding protein alpha activates Adenylate cyclase type 1
participant: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
participant: Adenylate cyclase type 1

Proheparin-binding EGF-like growth factor
type: ProteinReference
xref: Reference/UniProt Q99075
organism: Homo sapiens

Protein kinase C beta type
type: Protein
cellular location: Cytoplasm
entity reference: Protein kinase C beta type

Calcium
type: SmallMolecule
cellular location: Membrane
entity reference: Calcium

Protein/1117 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mitogen-activated protein kinase 1
stoichiometric coefficient: 1.0

Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0016020

Protein/3334 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cyclic AMP-dependent transcription factor ATF-4
stoichiometric coefficient: 1.0

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
cellular location: Membrane
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

Interaction551
type: MolecularInteraction
interaction type: direct_interaction
name: cAMP activates cAMP-dependent protein kinase catalytic subunit alpha
participant: cAMP-dependent protein kinase catalytic subunit alpha
participant: cAMP

Reference/TAXONOMY 4932
type: UnificationXref
id: 4932
db: TAXONOMY

Interaction550
type: MolecularInteraction
interaction type: direct_interaction
name: Adenylate cyclase type 1 activates cAMP
participant: Adenylate cyclase type 1
participant: cAMP

Interaction553
type: MolecularInteraction
interaction type: direct_interaction
name: Gonadotropin-releasing hormone receptor activates Guanine nucleotide-binding protein subunit alpha-11
participant: Gonadotropin-releasing hormone receptor
participant: Guanine nucleotide-binding protein subunit alpha-11

Interaction555
type: MolecularInteraction
interaction type: direct_interaction
name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta1 activates IP3
participant: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
participant: IP3

Interaction554
type: MolecularInteraction
interaction type: direct_interaction
name: Guanine nucleotide-binding protein subunit alpha-11 activates 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta1
participant: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
participant: Guanine nucleotide-binding protein subunit alpha-11

Interaction557
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium activates Calmodulin-like protein 6
participant: Calcium
participant: Calmodulin-like protein 6

Phosphate_Mitogen-activated protein kinase 1 (Homo sapiens)
type: Complex
component stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/1117 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Mitogen-activated protein kinase 1
component: Phosphate

Interaction556
type: MolecularInteraction
interaction type: direct_interaction
name: IP3 activates Inositol 1,4,5-trisphosphate receptor type 1
participant: IP3
participant: Inositol 1,4,5-trisphosphate receptor type 1

Calcium/calmodulin-dependent protein kinase type II subunit alpha
type: Protein
cellular location: Cytoplasm
entity reference: Calcium/calmodulin-dependent protein kinase type II subunit alpha

Reference/UniProt Q99075
type: UnificationXref
id: Q99075
db: UniProt

Interaction559
type: MolecularInteraction
interaction type: direct_interaction
name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta1 activates DG
participant: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
participant: DG

Interaction558
type: MolecularInteraction
interaction type: direct_interaction
name: Calmodulin-like protein 6 activates Ternary complex (LRRC7, CAMK2a, ACTN4)
participant: Ternary complex (LRRC7, CAMK2a, ACTN4)
participant: Calmodulin-like protein 6

Protein/2720 Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit beta-1
stoichiometric coefficient: 1.0

Voltage-dependent L-type calcium channel subunit alpha-1C
type: Protein
cellular location: Membrane
entity reference: Voltage-dependent L-type calcium channel subunit alpha-1C

Mitogen-activated protein kinase 1
type: Protein
cellular location: Nucleus
entity reference: Mitogen-activated protein kinase 1

Reference/UniProt P01148
type: UnificationXref
id: P01148
db: UniProt

Reference/HMDB HMDB0001043
type: UnificationXref
id: HMDB0001043
db: HMDB

Reference/UniProt Q13698
type: UnificationXref
id: Q13698
db: UniProt

Protein/2078 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dual specificity mitogen-activated protein kinase kinase 3
stoichiometric coefficient: 1.0

Nucleus
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005634

Reference/CAS 506-32-1
type: UnificationXref
id: 506-32-1
db: CAS

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/PubChem-compound 6076
type: UnificationXref
id: 6076
db: PubChem-compound

Interaction560
type: MolecularInteraction
interaction type: direct_interaction
name: DG activates Protein kinase C complex
participant: DG
participant: Protein kinase C complex

Compound/PW C001104 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Voltage-dependent L-type calcium channel
type: Complex
cellular location: Cytoplasm
component: Voltage-dependent L-type calcium channel subunit alpha-1D
component: Voltage-dependent L-type calcium channel subunit alpha-1F
component: Voltage-dependent L-type calcium channel subunit alpha-1S
component: Voltage-dependent L-type calcium channel subunit alpha-1C

Interaction562
type: MolecularInteraction
interaction type: direct_interaction
name: Voltage-dependent L-type calcium channel activates Protein kinase C complex
participant: Voltage-dependent L-type calcium channel
participant: Protein kinase C complex

Interaction561
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium activates Voltage-dependent L-type calcium channel
participant: Voltage-dependent L-type calcium channel
participant: Calcium

Calcium
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Calcium

Interaction564
type: MolecularInteraction
interaction type: direct_interaction
name: MMP2-MMP14 activates Proheparin-binding EGF-like growth factor
participant: MMP2-MMP14
participant: Proheparin-binding EGF-like growth factor

Mitogen-activated protein kinase kinase kinase 2
type: ProteinReference
xref: Reference/UniProt Q9Y2U5
organism: Homo sapiens

Mitogen-activated protein kinase 8
type: ProteinReference
xref: Reference/UniProt P45983
organism: Homo sapiens

Interaction563
type: MolecularInteraction
interaction type: direct_interaction
name: Protein kinase C complex activates Voltage-depenent L-type calcium channel
participant: Protein kinase C complex
participant: Voltage-depenent L-type calcium channel

Interaction566
type: MolecularInteraction
interaction type: direct_interaction
name: Epidermal growth factor receptor activates Growth factor receptor-bound protein 2
participant: Growth factor receptor-bound protein 2
participant: Epidermal growth factor receptor

Interaction565
type: MolecularInteraction
interaction type: direct_interaction
name: Proheparin-binding EGF-like growth factor activates Epidermal growth factor receptor
participant: Epidermal growth factor receptor
participant: Proheparin-binding EGF-like growth factor

Dual specificity mitogen-activated protein kinase kinase 3
type: ProteinReference
xref: Reference/UniProt P46734
organism: Homo sapiens

Transcription factor AP-1
type: ProteinReference
xref: Reference/UniProt P05412
organism: Homo sapiens

Interaction567
type: MolecularInteraction
interaction type: direct_interaction
name: Son of sevenless homolog 1 activates GTPase HRas
participant: GTPase HRas
participant: Son of sevenless homolog 1

GTPase HRas
type: Protein
cellular location: Cytoplasm
entity reference: GTPase HRas

Compound/PW C000353 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/UniProt P18146
type: UnificationXref
id: P18146
db: UniProt

Early growth response protein 1
type: ProteinReference
xref: Reference/UniProt P18146
organism: Homo sapiens

Phosphate_Dual specificity mitogen-activated protein kinase kinase 7 (Homo sapiens)
type: Complex
component stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/3977 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Phosphate
component: Dual specificity mitogen-activated protein kinase kinase 7

IP3
type: SmallMolecule
cellular location: Cytoplasm
entity reference: IP3

MMP2-MMP14
type: Complex
cellular location: Extracellular Space
component: 72 kDa type IV collagenase
component: Matrix metalloproteinase-14

Reference/BioCyc ARACHIDONIC ACID
type: UnificationXref
id: ARACHIDONIC_ACID
db: BioCyc

Dual specificity mitogen-activated protein kinase kinase 3
type: Protein
cellular location: Cytoplasm
entity reference: Dual specificity mitogen-activated protein kinase kinase 3

Reference/UniProt P17612
type: UnificationXref
id: P17612
db: UniProt

Ternary complex (LRRC7, CAMK2a, ACTN4)
type: Complex
component stoichiometry: Protein/9229 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/9550 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/9551 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Alpha-actinin-4
component: Leucine-rich repeat-containing protein 7
component: Calcium/calmodulin-dependent protein kinase type II subunit alpha

Protein/3977 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dual specificity mitogen-activated protein kinase kinase 7
stoichiometric coefficient: 1.0

Lutropin subunit beta
type: Protein
cellular location: Nucleus
entity reference: Lutropin subunit beta

Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Protein/1351 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Epidermal growth factor receptor
stoichiometric coefficient: 2.0