Protein/14674 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Properdin
stoichiometric coefficient: 1.0

Complement component C8 alpha chain
type: Protein
cellular location: Extracellular Space
entity reference: Complement component C8 alpha chain

Magnesium
type: SmallMoleculeReference
xref: Reference/BioCyc 13-HYDROXY-MAGNESIUM-PROTOPORP
xref: Reference/KEGG Compound C00305
xref: Reference/HMDB HMDB0000547
xref: Reference/CAS 22537-22-0
xref: Reference/PubChem-compound 888
xref: Reference/ChEBI CHEBI 18420
xref: Reference/ChemSpider 865
chemical formula: Mg
molecular weight: 23.985043
structure: ChemicalStructure/PW C000423

Reference/PubChem-compound 888
type: UnificationXref
id: 888
db: PubChem-compound

Protein/14656 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Complement factor Bb
stoichiometric coefficient: 1.0

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Properdin (Homo sapiens)_Complement C5b (Homo sapiens)_Complement factor B-b (Homo sapiens)_Complement C3b (Homo sapiens)_Complement component C6 (Homo sapiens)
type: Complex
component stoichiometry: Protein/14656/Stoichiometry/1.0
component stoichiometry: Protein/14651/Stoichiometry/1.0
component stoichiometry: Protein/14674/Stoichiometry/1.0
component stoichiometry: Protein/14582/Stoichiometry/1.0
component stoichiometry: Protein/14653/Stoichiometry/1.0
component: Complement C3b
component: Complement factor Bb
component: Properdin
component: Complement component C6
component: Complement C5b

Properdin (Homo sapiens)_Complement factor B-b (Homo sapiens)_Complement C3b (Homo sapiens)_Complement C5 (Homo sapiens)
type: Complex
component stoichiometry: Protein/14656/Stoichiometry/1.0
component stoichiometry: Protein/14674/Stoichiometry/1.0
component stoichiometry: Protein/14582/Stoichiometry/1.0
component stoichiometry: Protein/14650/Stoichiometry/1.0
component: Complement C3b
component: Complement factor Bb
component: Properdin
component: Complement C5

Protein/14652 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Complement component C9
stoichiometric coefficient: 1.0

Complement C3b
type: Protein
entity reference: Complement C3b

direct_interaction
type: InteractionVocabulary

Complement factor B-b (Homo sapiens)_Complement C3b (Homo sapiens)
type: Complex
component stoichiometry: Protein/14582 Extracellular Space/Stoichiometry/1.0
component stoichiometry: Protein/14656 Extracellular Space/Stoichiometry/1.0
cellular location: Extracellular Space
component: Complement factor Bb
component: Complement C3b

Protein/14656/Stoichiometry/1.0
type: Stoichiometry
physical entity: Complement factor Bb
stoichiometric coefficient: 1.0

Complement factor Bb
type: Protein
cellular location: Extracellular Space
entity reference: Complement factor Bb

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/UniProt P00751
type: UnificationXref
id: P00751
db: UniProt

Complement C5a
type: ProteinReference
xref: Reference/UniProt P01031
organism: Homo sapiens

Protein/14582/Stoichiometry/1.0
type: Stoichiometry
physical entity: Complement C3b
stoichiometric coefficient: 1.0

Complement factor Bb
type: ProteinReference
xref: Reference/UniProt P00751
organism: Homo sapiens

Protein/14582 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Complement C3b
stoichiometric coefficient: 1.0

Complement component C8 alpha chain
type: ProteinReference
xref: Reference/UniProt P07357
organism: Homo sapiens

Complement component C7
type: ProteinReference
xref: Reference/UniProt P10643
organism: Homo sapiens

Complement component C6
type: ProteinReference
xref: Reference/UniProt P13671

Complement component C9
type: ProteinReference
xref: Reference/UniProt P02748
organism: Homo sapiens

Complement C5b
type: ProteinReference
xref: Reference/UniProt P01031

Complement C5
type: ProteinReference
xref: Reference/UniProt P01031
organism: Homo sapiens

Complement factor B (Homo sapiens)_Complement C3b (Homo sapiens)
type: Complex
component stoichiometry: Protein/14582 Extracellular Space/Stoichiometry/1.0
component stoichiometry: Protein/14665 Extracellular Space/Stoichiometry/1.0
cellular location: Extracellular Space
component: Complement C3b
component: Complement factor B

Transport1208
type: Transport
participant stoichiometry: BoundComplex/66 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: BoundComplex/66 Extracellular Space/Stoichiometry/1.0
right: Complement C5b (Homo sapiens)_Complement component C6 (Homo sapiens)_Complement component C7 (Homo sapiens)
spontaneous: false
left: Complement C5b (Homo sapiens)_Complement component C6 (Homo sapiens)_Complement component C7 (Homo sapiens)
name: Complement C5b (Homo sapiens) + Complement component C6 (Homo sapiens) + Complement component C7 (Homo sapiens) (?) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell Membrane
conversion direction: LEFT_TO_RIGHT

Complement component C7
type: Protein
cellular location: Extracellular Space
entity reference: Complement component C7

Compound/PW C001420 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/UniProt P13671
type: UnificationXref
id: P13671
db: UniProt

Reference/SMPDB SMP0063815
type: UnificationXref
id: SMP0063815
db: SMPDB

Reference/HMDB HMDB0000547
type: UnificationXref
id: HMDB0000547
db: HMDB

Complement C5b (Homo sapiens)_Complement component C6 (Homo sapiens)_Complement component C7 (Homo sapiens)_Complement component C8 (Homo sapiens)
type: Complex
component stoichiometry: Protein/14653 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/14654 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/14651 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/14655 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Complement component C7
component: Complement component C8 alpha chain
component: Complement C5b
component: Complement component C6

Complement component C6
type: Protein
cellular location: Cell Membrane
entity reference: Complement component C6

Complement factor B
type: ProteinReference
xref: Reference/UniProt P00751
organism: Homo sapiens

Complement factor D
type: ProteinReference
xref: Reference/UniProt P00746
organism: Homo sapiens

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Properdin (Homo sapiens)_Complement C5b (Homo sapiens)_Complement factor B-b (Homo sapiens)_Complement C3b (Homo sapiens)_Complement component C6 (Homo sapiens)
type: Complex
component stoichiometry: Protein/14674 Extracellular Space/Stoichiometry/1.0
component stoichiometry: Protein/14582 Extracellular Space/Stoichiometry/1.0
component stoichiometry: Protein/14656 Extracellular Space/Stoichiometry/1.0
component stoichiometry: Protein/14651 Extracellular Space/Stoichiometry/1.0
component stoichiometry: Protein/14653 Extracellular Space/Stoichiometry/1.0
cellular location: Extracellular Space
component: Properdin
component: Complement factor Bb
component: Complement component C6
component: Complement C3b
component: Complement C5b

ChemicalStructure/PW C000423
type: ChemicalStructure
structure format: SMILES
structure data: [Mg++]

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Properdin
type: Protein
entity reference: Properdin

Protein/14653 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Complement component C6
stoichiometric coefficient: 1.0

Interaction638
type: MolecularInteraction
interaction type: direct_interaction
name: Complement C3 activates Complement C3
participant: Complement C3

Reference/PathWhiz PW064820
type: UnificationXref
id: PW064820
db: PathWhiz

Complement component C6
type: Protein
cellular location: Extracellular Space
entity reference: Complement component C6

Reference/CAS 22537-22-0
type: UnificationXref
id: 22537-22-0
db: CAS

Alternative Complement Pathway
type: Pathway
pathway order: PathwayInteraction/654
pathway order: PathwayInteraction/665
pathway order: PathwayInteraction/655
pathway order: PathwayInteraction/666
pathway order: PathwayInteraction/656
pathway order: PathwayInteraction/667
pathway order: PathwayInteraction/657
pathway order: PathwayInteraction/668
pathway order: PathwayInteraction/647
pathway order: PathwayInteraction/658
pathway order: PathwayInteraction/648
pathway order: PathwayInteraction/659
pathway order: PathwayInteraction/638
pathway order: PathwayInteraction/649
pathway order: PathwayTransport/1193047
pathway order: PathwayInteraction/660
pathway order: PathwayInteraction/650
pathway order: PathwayInteraction/661
pathway order: PathwayInteraction/651
pathway order: PathwayInteraction/662
pathway order: PathwayInteraction/652
pathway order: PathwayInteraction/663
pathway order: PathwayInteraction/653
pathway order: PathwayInteraction/664
pathway component: Interaction650
pathway component: Interaction661
pathway component: Interaction660
pathway component: Interaction652
pathway component: Interaction663
pathway component: Interaction651
pathway component: Interaction662
pathway component: Interaction654
pathway component: Interaction665
pathway component: Interaction653
pathway component: Interaction664
pathway component: Transport1208
pathway component: Interaction656
pathway component: Interaction667
pathway component: Interaction655
pathway component: Interaction666
pathway component: Interaction647
pathway component: Interaction658
pathway component: Interaction657
pathway component: Interaction668
pathway component: Interaction638
pathway component: Interaction649
pathway component: Interaction648
pathway component: Interaction659
xref: Reference/PathWhiz PW064820
xref: Reference/SMPDB SMP0063815
organism: Homo sapiens

BoundComplex/66 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Complement C5b (Homo sapiens)_Complement component C6 (Homo sapiens)_Complement component C7 (Homo sapiens)
stoichiometric coefficient: 1.0

Water
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Water

Protein/14655 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Complement component C8 alpha chain
stoichiometric coefficient: 1.0

Properdin
type: ProteinReference
xref: Reference/UniProt P27918
organism: Homo sapiens

Properdin (Homo sapiens)_Complement factor B-b (Homo sapiens)_Complement C3b (Homo sapiens)_Complement C5 (Homo sapiens)
type: Complex
component stoichiometry: Protein/14674 Extracellular Space/Stoichiometry/1.0
component stoichiometry: Protein/14582 Extracellular Space/Stoichiometry/1.0
component stoichiometry: Protein/14650 Extracellular Space/Stoichiometry/1.0
component stoichiometry: Protein/14656 Extracellular Space/Stoichiometry/1.0
cellular location: Extracellular Space
component: Properdin
component: Complement factor Bb
component: Complement C5
component: Complement C3b

Interaction647
type: MolecularInteraction
interaction type: direct_interaction
name: Complement C3 activates Water + Complement C3 (Homo sapiens)
participant: Water_Complement C3 (Homo sapiens)
participant: Complement C3

Protein/14674/Stoichiometry/1.0
type: Stoichiometry
physical entity: Properdin
stoichiometric coefficient: 1.0

Interaction649
type: MolecularInteraction
interaction type: direct_interaction
name: Complement factor B activates Complement factor B (Homo sapiens) + Complement C3 (Homo sapiens) + Water
participant: Complement factor B
participant: Complement factor B (Homo sapiens)_Complement C3 (Homo sapiens)_Water

Interaction648
type: MolecularInteraction
interaction type: direct_interaction
name: Water activates Water + Complement C3 (Homo sapiens)
participant: Water_Complement C3 (Homo sapiens)
participant: Water

Reference/ChEBI CHEBI 18420
type: UnificationXref
id: CHEBI:18420
db: ChEBI

Complement component C8 alpha chain
type: Protein
cellular location: Cell Membrane
entity reference: Complement component C8 alpha chain

Complement C3b
type: Protein
cellular location: Extracellular Space
entity reference: Complement C3b

Protein/14654 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Complement component C7
stoichiometric coefficient: 1.0

Complement factor B-b (Homo sapiens)_Complement C3b (Homo sapiens)_Properdin (Homo sapiens)
type: Complex
component stoichiometry: Protein/14582 Extracellular Space/Stoichiometry/1.0
component stoichiometry: Protein/14674 Extracellular Space/Stoichiometry/1.0
component stoichiometry: Protein/14656 Extracellular Space/Stoichiometry/1.0
cellular location: Extracellular Space
component: Properdin
component: Complement factor Bb
component: Complement C3b

Complement component C9
type: Protein
cellular location: Extracellular Space
entity reference: Complement component C9

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Protein/14665 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Complement factor B
stoichiometric coefficient: 1.0

Protein/14650 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Complement C5
stoichiometric coefficient: 1.0

Protein/14654 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Complement component C7
stoichiometric coefficient: 1.0

Interaction650
type: MolecularInteraction
interaction type: direct_interaction
name: Water + Complement C3 (Homo sapiens) activates Complement factor B (Homo sapiens) + Complement C3 (Homo sapiens) + Water
participant: Water_Complement C3 (Homo sapiens)
participant: Complement factor B (Homo sapiens)_Complement C3 (Homo sapiens)_Water

Complement C5
type: Protein
cellular location: Extracellular Space
entity reference: Complement C5

Interaction652
type: MolecularInteraction
interaction type: direct_interaction
name: Complement factor B (Homo sapiens) + Complement C3 (Homo sapiens) + Water activates Complement factor B (Homo sapiens) + Complement C3b (Homo sapiens)
participant: Complement factor B (Homo sapiens)_Complement C3b (Homo sapiens)
participant: Complement factor B (Homo sapiens)_Complement C3 (Homo sapiens)_Water

Interaction651
type: MolecularInteraction
interaction type: direct_interaction
name: Magnesium activates Complement factor B (Homo sapiens) + Complement C3 (Homo sapiens) + Water
participant: Magnesium
participant: Complement factor B (Homo sapiens)_Complement C3 (Homo sapiens)_Water

Interaction654
type: MolecularInteraction
interaction type: direct_interaction
name: Complement factor B (Homo sapiens) + Complement C3b (Homo sapiens) activates Complement factor B-b (Homo sapiens) + Complement C3b (Homo sapiens)
participant: Complement factor B-b (Homo sapiens)_Complement C3b (Homo sapiens)
participant: Complement factor B (Homo sapiens)_Complement C3b (Homo sapiens)

Complement factor Bb
type: Protein
entity reference: Complement factor Bb

Interaction653
type: MolecularInteraction
interaction type: direct_interaction
name: Complement factor B (Homo sapiens) + Complement C3 (Homo sapiens) + Water activates Complement C3a
participant: Complement C3a
participant: Complement factor B (Homo sapiens)_Complement C3 (Homo sapiens)_Water

Interaction656
type: MolecularInteraction
interaction type: direct_interaction
name: Complement factor B-b (Homo sapiens) + Complement C3b (Homo sapiens) activates Complement factor B-a
participant: Complement factor Ba
participant: Complement factor B-b (Homo sapiens)_Complement C3b (Homo sapiens)

Interaction655
type: MolecularInteraction
interaction type: direct_interaction
name: Complement factor D activates Complement factor B-b (Homo sapiens) + Complement C3b (Homo sapiens)
participant: Complement factor B-b (Homo sapiens)_Complement C3b (Homo sapiens)
participant: Complement factor D

Interaction658
type: MolecularInteraction
interaction type: direct_interaction
name: Properdin activates Complement factor B-b (Homo sapiens) + Complement C3b (Homo sapiens) + Properdin (Homo sapiens)
participant: Properdin
participant: Complement factor B-b (Homo sapiens)_Complement C3b (Homo sapiens)_Properdin (Homo sapiens)

Interaction657
type: MolecularInteraction
interaction type: direct_interaction
name: Complement factor B-b (Homo sapiens) + Complement C3b (Homo sapiens) activates Complement factor B-b (Homo sapiens) + Complement C3b (Homo sapiens) + Properdin (Homo sapiens)
participant: Complement factor B-b (Homo sapiens)_Complement C3b (Homo sapiens)
participant: Complement factor B-b (Homo sapiens)_Complement C3b (Homo sapiens)_Properdin (Homo sapiens)

Complement C5a
type: Protein
cellular location: Extracellular Space
entity reference: Complement C5a

Complement component C6
type: Protein
entity reference: Complement component C6

Complement C5
type: Protein
entity reference: Complement C5

Interaction659
type: MolecularInteraction
interaction type: direct_interaction
name: Complement factor B-b (Homo sapiens) + Complement C3b (Homo sapiens) + Properdin (Homo sapiens) activates Properdin (Homo sapiens) + Complement factor B-b (Homo sapiens) + Complement C3b (Homo sapiens) + Complement C5 (Homo sapiens)
participant: Properdin (Homo sapiens)_Complement factor B-b (Homo sapiens)_Complement C3b (Homo sapiens)_Complement C5 (Homo sapiens)
participant: Complement factor B-b (Homo sapiens)_Complement C3b (Homo sapiens)_Properdin (Homo sapiens)

Complement C5b
type: Protein
entity reference: Complement C5b

Complement C3a
type: Protein
cellular location: Extracellular Space
entity reference: Complement C3a

Reference/UniProt P27918
type: UnificationXref
id: P27918
db: UniProt

Complement component C7
type: Protein
cellular location: Cell Membrane
entity reference: Complement component C7

BoundComplex/66 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Complement C5b (Homo sapiens)_Complement component C6 (Homo sapiens)_Complement component C7 (Homo sapiens)
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Complement C5b (Homo sapiens)_Complement component C6 (Homo sapiens)_Complement component C7 (Homo sapiens)
type: Complex
component stoichiometry: Protein/14653 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/14654 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/14651 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Complement component C7
component: Complement C5b
component: Complement component C6

Complement C5b (Homo sapiens)_Complement component C6 (Homo sapiens)_Complement component C7 (Homo sapiens)_Complement component C8 (Homo sapiens)
type: Complex
component stoichiometry: Protein/14654 Extracellular Space/Stoichiometry/1.0
component stoichiometry: Protein/14655 Extracellular Space/Stoichiometry/1.0
component stoichiometry: Protein/14651 Extracellular Space/Stoichiometry/1.0
component stoichiometry: Protein/14653 Extracellular Space/Stoichiometry/1.0
cellular location: Extracellular Space
component: Complement component C6
component: Complement component C8 alpha chain
component: Complement C5b
component: Complement component C7

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Complement C5b
type: Protein
cellular location: Extracellular Space
entity reference: Complement C5b

Protein/14650/Stoichiometry/1.0
type: Stoichiometry
physical entity: Complement C5
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Protein/14584 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Complement C3
stoichiometric coefficient: 1.0

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/UniProt P07357
type: UnificationXref
id: P07357
db: UniProt

Protein/14653 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Complement component C6
stoichiometric coefficient: 1.0

Reference/UniProt P10643
type: UnificationXref
id: P10643
db: UniProt

Interaction661
type: MolecularInteraction
interaction type: direct_interaction
name: Properdin (Homo sapiens) + Complement factor B-b (Homo sapiens) + Complement C3b (Homo sapiens) + Complement C5 (Homo sapiens) activates Properdin (Homo sapiens) + Complement C5b (Homo sapiens) + Complement factor B-b (Homo sapiens) + Complement C3b (Homo sapiens) + Complement component C6 (Homo sapiens)
participant: Properdin (Homo sapiens)_Complement C5b (Homo sapiens)_Complement factor B-b (Homo sapiens)_Complement C3b (Homo sapiens)_Complement component C6 (Homo sapiens)
participant: Properdin (Homo sapiens)_Complement factor B-b (Homo sapiens)_Complement C3b (Homo sapiens)_Complement C5 (Homo sapiens)

Protein/14651/Stoichiometry/1.0
type: Stoichiometry
physical entity: Complement C5b
stoichiometric coefficient: 1.0

Interaction660
type: MolecularInteraction
interaction type: direct_interaction
name: Properdin (Homo sapiens) + Complement factor B-b (Homo sapiens) + Complement C3b (Homo sapiens) + Complement C5 (Homo sapiens) activates Complement C5a
participant: Properdin (Homo sapiens)_Complement factor B-b (Homo sapiens)_Complement C3b (Homo sapiens)_Complement C5 (Homo sapiens)
participant: Complement C5a

Interaction663
type: MolecularInteraction
interaction type: direct_interaction
name: Properdin (Homo sapiens) + Complement C5b (Homo sapiens) + Complement factor B-b (Homo sapiens) + Complement C3b (Homo sapiens) + Complement component C6 (Homo sapiens) activates Complement C5b (Homo sapiens) + Complement component C6 (Homo sapiens) + Complement component C7 (Homo sapiens)
participant: Complement C5b (Homo sapiens)_Complement component C6 (Homo sapiens)_Complement component C7 (Homo sapiens)
participant: Properdin (Homo sapiens)_Complement C5b (Homo sapiens)_Complement factor B-b (Homo sapiens)_Complement C3b (Homo sapiens)_Complement component C6 (Homo sapiens)

Interaction662
type: MolecularInteraction
interaction type: direct_interaction
name: Complement component C6 activates Properdin (Homo sapiens) + Complement C5b (Homo sapiens) + Complement factor B-b (Homo sapiens) + Complement C3b (Homo sapiens) + Complement component C6 (Homo sapiens)
participant: Complement component C6
participant: Properdin (Homo sapiens)_Complement C5b (Homo sapiens)_Complement factor B-b (Homo sapiens)_Complement C3b (Homo sapiens)_Complement component C6 (Homo sapiens)

Complement C3
type: Protein
cellular location: Extracellular Space
entity reference: Complement C3

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Interaction665
type: MolecularInteraction
interaction type: direct_interaction
name: Complement C5b (Homo sapiens) + Complement component C6 (Homo sapiens) + Complement component C7 (Homo sapiens) activates Complement C5b (Homo sapiens) + Complement component C6 (Homo sapiens) + Complement component C7 (Homo sapiens) + Complement component C8 (Homo sapiens)
participant: Complement C5b (Homo sapiens)_Complement component C6 (Homo sapiens)_Complement component C7 (Homo sapiens)
participant: Complement C5b (Homo sapiens)_Complement component C6 (Homo sapiens)_Complement component C7 (Homo sapiens)_Complement component C8 (Homo sapiens)

Interaction664
type: MolecularInteraction
interaction type: direct_interaction
name: Complement component C7 activates Complement C5b (Homo sapiens) + Complement component C6 (Homo sapiens) + Complement component C7 (Homo sapiens)
participant: Complement C5b (Homo sapiens)_Complement component C6 (Homo sapiens)_Complement component C7 (Homo sapiens)
participant: Complement component C7

Interaction667
type: MolecularInteraction
interaction type: direct_interaction
name: Complement C5b (Homo sapiens) + Complement component C6 (Homo sapiens) + Complement component C7 (Homo sapiens) + Complement component C8 (Homo sapiens) activates Complement C5b (Homo sapiens) + Complement component C6 (Homo sapiens) + Complement component C7 (Homo sapiens) + Complement component C8 (Homo sapiens) + Complement component C9 (Homo sapiens)
participant: Complement C5b (Homo sapiens)_Complement component C6 (Homo sapiens)_Complement component C7 (Homo sapiens)_Complement component C8 (Homo sapiens)_Complement component C9 (Homo sapiens)
participant: Complement C5b (Homo sapiens)_Complement component C6 (Homo sapiens)_Complement component C7 (Homo sapiens)_Complement component C8 (Homo sapiens)

Interaction666
type: MolecularInteraction
interaction type: direct_interaction
name: Complement component C8 activates Complement C5b (Homo sapiens) + Complement component C6 (Homo sapiens) + Complement component C7 (Homo sapiens) + Complement component C8 (Homo sapiens)
participant: Complement component C8 alpha chain
participant: Complement C5b (Homo sapiens)_Complement component C6 (Homo sapiens)_Complement component C7 (Homo sapiens)_Complement component C8 (Homo sapiens)

Interaction668
type: MolecularInteraction
interaction type: direct_interaction
name: Complement component C9 activates Complement C5b (Homo sapiens) + Complement component C6 (Homo sapiens) + Complement component C7 (Homo sapiens) + Complement component C8 (Homo sapiens) + Complement component C9 (Homo sapiens)
participant: Complement component C9
participant: Complement C5b (Homo sapiens)_Complement component C6 (Homo sapiens)_Complement component C7 (Homo sapiens)_Complement component C8 (Homo sapiens)_Complement component C9 (Homo sapiens)

Reference/BioCyc 13-HYDROXY-MAGNESIUM-PROTOPORP
type: UnificationXref
id: 13-HYDROXY-MAGNESIUM-PROTOPORP
db: BioCyc

Complement C5b (Homo sapiens)_Complement component C6 (Homo sapiens)_Complement component C7 (Homo sapiens)
type: Complex
component stoichiometry: Protein/14654 Extracellular Space/Stoichiometry/1.0
component stoichiometry: Protein/14651 Extracellular Space/Stoichiometry/1.0
component stoichiometry: Protein/14653 Extracellular Space/Stoichiometry/1.0
cellular location: Extracellular Space
component: Complement component C6
component: Complement C5b
component: Complement component C7

Reference/UniProt P02748
type: UnificationXref
id: P02748
db: UniProt

Complement factor Ba
type: Protein
cellular location: Extracellular Space
entity reference: Complement factor Ba

Complement C5b (Homo sapiens)_Complement component C6 (Homo sapiens)_Complement component C7 (Homo sapiens)_Complement component C8 (Homo sapiens)_Complement component C9 (Homo sapiens)
type: Complex
component stoichiometry: Protein/14653 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/14654 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/14652 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/14651 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/14655 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Complement component C7
component: Complement component C8 alpha chain
component: Complement C5b
component: Complement component C9
component: Complement component C6

Complement factor Ba
type: ProteinReference
xref: Reference/UniProt P00751
organism: Homo sapiens

Protein/14655 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Complement component C8 alpha chain
stoichiometric coefficient: 1.0

Complement C3
type: ProteinReference
xref: Reference/UniProt P01024
organism: Homo sapiens

Reference/UniProt P01024
type: UnificationXref
id: P01024
db: UniProt

Complement C3a
type: ProteinReference
xref: Reference/UniProt P01024
organism: Homo sapiens

Complement C3b
type: ProteinReference
xref: Reference/UniProt P01024
organism: Homo sapiens

Protein/14652 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Complement component C9
stoichiometric coefficient: 1.0

Protein/14651 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Complement C5b
stoichiometric coefficient: 1.0

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Complement factor B (Homo sapiens)_Complement C3 (Homo sapiens)_Water
type: Complex
component stoichiometry: Protein/14584 Extracellular Space/Stoichiometry/1.0
component stoichiometry: Compound/PW C001420 Extracellular Space/Stoichiometry/1.0
component stoichiometry: Protein/14665 Extracellular Space/Stoichiometry/1.0
cellular location: Extracellular Space
component: Complement C3
component: Water
component: Complement factor B

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Complement factor D
type: Protein
cellular location: Extracellular Space
entity reference: Complement factor D

Complement component C9
type: Protein
cellular location: Cell Membrane
entity reference: Complement component C9

Protein/14653/Stoichiometry/1.0
type: Stoichiometry
physical entity: Complement component C6
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00305
type: UnificationXref
id: C00305
db: KEGG Compound

Magnesium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Magnesium

Reference/UniProt P01031
type: UnificationXref
id: P01031
db: UniProt

Complement C5b
type: Protein
cellular location: Cell Membrane
entity reference: Complement C5b

Complement factor B
type: Protein
cellular location: Extracellular Space
entity reference: Complement factor B

Reference/ChemSpider 865
type: UnificationXref
id: 865
db: ChemSpider

Water_Complement C3 (Homo sapiens)
type: Complex
component stoichiometry: Protein/14584 Extracellular Space/Stoichiometry/1.0
component stoichiometry: Compound/PW C001420 Extracellular Space/Stoichiometry/1.0
cellular location: Extracellular Space
component: Complement C3
component: Water

Properdin
type: Protein
cellular location: Extracellular Space
entity reference: Properdin

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Protein/14651 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Complement C5b
stoichiometric coefficient: 1.0

Reference/UniProt P00746
type: UnificationXref
id: P00746
db: UniProt

Complement C5b (Homo sapiens)_Complement component C6 (Homo sapiens)_Complement component C7 (Homo sapiens)_Complement component C8 (Homo sapiens)_Complement component C9 (Homo sapiens)
type: Complex
component stoichiometry: Protein/14654 Extracellular Space/Stoichiometry/1.0
component stoichiometry: Protein/14655 Extracellular Space/Stoichiometry/1.0
component stoichiometry: Protein/14651 Extracellular Space/Stoichiometry/1.0
component stoichiometry: Protein/14653 Extracellular Space/Stoichiometry/1.0
component stoichiometry: Protein/14652 Extracellular Space/Stoichiometry/1.0
cellular location: Extracellular Space
component: Complement component C6
component: Complement component C8 alpha chain
component: Complement C5b
component: Complement component C7
component: Complement component C9