Reference/ChEBI CHEBI 17587
type: UnificationXref
id: CHEBI:17587
db: ChEBI

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Reference/CAS 7722-84-1
type: UnificationXref
id: 7722-84-1
db: CAS

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/PubChem-compound 6146
type: UnificationXref
id: 6146
db: PubChem-compound

Reference/HMDB HMDB0003125
type: UnificationXref
id: HMDB0003125
db: HMDB

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

ChemicalStructure/PW C001783
type: ChemicalStructure
structure format: SMILES
structure data: OO

Ascorbic acid
type: SmallMoleculeReference
xref: Reference/BioCyc ASCORBATE
xref: Reference/ChemSpider 10189562
xref: Reference/KEGG Compound C00072
xref: Reference/ChEBI CHEBI 29073
xref: Reference/CAS 50-81-7
xref: Reference/PubChem-compound 54670067
xref: Reference/HMDB HMDB0000044
chemical formula: C6H8O6
molecular weight: 176.03209
structure: ChemicalStructure/PW C000031

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/CAS 2616-64-0
type: UnificationXref
id: 2616-64-0
db: CAS

NADPH
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: NADPH

Reaction143014
type: BiochemicalReaction
participant stoichiometry: Compound/PW C102448/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000031/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Ascorbic acid
right: Hydrogen Ion
spontaneous: true
left: L-xylo-Hexulonolactone
name: L-xylo-Hexulonolactone → Ascorbic acid + Hydrogen Ion
conversion direction: LEFT_TO_RIGHT

Compound/PW C000146 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

ReactionCatalysis129169
type: Catalysis
controller: Alcohol dehydrogenase [NADP(+)]
controlled: 1.1.1.2
control type: ACTIVATION

Reference/CAS 20246-53-1
type: UnificationXref
id: 20246-53-1
db: CAS

Reference/TAXONOMY 10090
type: UnificationXref
id: 10090
db: TAXONOMY

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Reference/BRENDA TISSUE ONTOLOGY BTO 0000759
type: UnificationXref
id: BTO:0000759
db: BRENDA TISSUE ONTOLOGY

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/ChEBI CHEBI 17200
type: UnificationXref
id: CHEBI:17200
db: ChEBI

ReactionCatalysis130126
type: Catalysis
controller: Regucalcin
controlled: 3.1.1.17
control type: ACTIVATION

Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/KEGG Compound C03289
type: UnificationXref
id: C03289
db: KEGG Compound

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Hydrogen Ion
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Hydrogen Ion

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Ascorbic acid
type: SmallMolecule
entity reference: Ascorbic acid

Reference/PathWhiz PW064822
type: UnificationXref
id: PW064822
db: PathWhiz

Reference/ChemSpider 10189562
type: UnificationXref
id: 10189562
db: ChemSpider

Hydrogen peroxide
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Hydrogen peroxide

Compound/PW C000201 Smooth Endoplasmic Reticulum /Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine 5'-diphosphate
stoichiometric coefficient: 1.0

Ascorbate Biosynthesis
type: Pathway
pathway order: PathwayEnzymeReaction/1722391
pathway order: PathwayEnzymeReaction/1722407
pathway order: PathwayEnzymeReaction/1602109
pathway order: PathwaySubPathway/93625
pathway order: PathwayEnzymeReaction/1722455
pathway order: PathwayEnzymeReaction/1722377
pathway order: PathwayEnzymeReaction/1722386
pathway component: 3.2.1.31
pathway component: Reaction3057
pathway component: Reaction140691
pathway component: Reaction143014
pathway component: ReactionCatalysis129169
pathway component: UDP-α-D-glucuronate Biosynthesis
pathway component: 3.1.1.17
pathway component: ReactionCatalysis101191
pathway component: 1.1.1.2
pathway component: ReactionCatalysis130765
pathway component: ReactionCatalysis130126
xref: Reference/SMPDB SMP0063817
xref: Reference/PathWhiz PW064822
organism: Mus musculus

Compound/PW C001902 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Gulonolactone
stoichiometric coefficient: 1.0

Reference/BioCyc UDP-GLUCURONATE
type: UnificationXref
id: UDP-GLUCURONATE
db: BioCyc

Reference/PubChem-compound 6031
type: UnificationXref
id: 6031
db: PubChem-compound

Reference/ChEBI CHEBI 16240
type: UnificationXref
id: CHEBI:16240
db: ChEBI

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

L-Gulonolactone
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003466
xref: Reference/ChEBI CHEBI 17587
xref: Reference/PubChem-compound 439373
xref: Reference/KEGG Compound C01040
xref: Reference/ChemSpider 388493
xref: Reference/BioCyc 2-KETO-L-GULONOLACTONE
xref: Reference/CAS 1128-23-0
chemical formula: C6H10O6
molecular weight: 178.04774
structure: ChemicalStructure/PW C001902

Regucalcin
type: Protein
entity reference: Regucalcin

ChemicalStructure/PW C000201
type: ChemicalStructure
structure format: SMILES

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

L-xylo-Hexulonolactone
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: L-xylo-Hexulonolactone

Mus musculus
type: BioSource
xref: Reference/TAXONOMY 10090

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H29N7O17P3
molecular weight: 744.08325
structure: ChemicalStructure/PW C000143

Uridine diphosphate glucuronic acid
type: SmallMoleculeReference
xref: Reference/BioCyc UDP-GLUCURONATE
xref: Reference/CAS 2616-64-0
xref: Reference/PubChem-compound 17473
xref: Reference/HMDB HMDB0000935
xref: Reference/ChEBI CHEBI 17200
xref: Reference/ChemSpider 16522
xref: Reference/KEGG Compound C00167
chemical formula: C15H22N2O18P2
molecular weight: 580.0343
structure: ChemicalStructure/PW C000746

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

L-xylo-Hexulonolactone
type: SmallMolecule
entity reference: L-xylo-Hexulonolactone

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

Gulonic acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00800
xref: Reference/PubChem-compound 152304
xref: Reference/HMDB HMDB0003290
xref: Reference/ChEBI CHEBI 16154
xref: Reference/BioCyc 2,3-diketo-l-gulonate
xref: Reference/CAS 20246-53-1
xref: Reference/ChemSpider 134243
chemical formula: C6H12O7
molecular weight: 196.0583
structure: ChemicalStructure/PW C001830

UDP-α-D-glucuronate Biosynthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway93625
pathway component: SubPathwayInteraction93625
name: SubPathway

Gulonic acid
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Gulonic acid

1.1.1.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001830 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041003 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Gulonic acid
right: NADP
spontaneous: false
EC number: 1.1.1.2
left: NADPH
left: aldehydo-D-glucuronate
left: Hydrogen Ion
name: Hydrogen Ion + NADPH + aldehydo-D-glucuronate → Gulonic acid + NADP
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

aldehydo-D-glucuronate
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: aldehydo-D-glucuronate

Beta-glucuronidase
type: Protein
cellular location: Smooth Endoplasmic Reticulum
entity reference: Beta-glucuronidase

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

SubPathwayInteraction93625
type: Interaction
name: SubPathway93625Reaction
name: SubPathwayReaction
participant: Uridine diphosphate glucuronic acid

Reference/KEGG Compound C00800
type: UnificationXref
id: C00800
db: KEGG Compound

L-gulonolactone oxidase
type: ProteinReference
xref: Reference/UniProt P58710
organism: BiologicalState359

Hydrogen Ion
type: SmallMolecule
cellular location: Smooth Endoplasmic Reticulum
entity reference: Hydrogen Ion

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Oxygen
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Oxygen

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/PubChem-compound 152304
type: UnificationXref
id: 152304
db: PubChem-compound

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/HMDB HMDB0003290
type: UnificationXref
id: HMDB0003290
db: HMDB

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/CAS 50-81-7
type: UnificationXref
id: 50-81-7
db: CAS

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

ChemicalStructure/PW C001902
type: ChemicalStructure
structure format: SMILES

Liver
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000759

BiologicalState359
type: BioSource
xref: Reference/TAXONOMY 10090
name: Mus musculus, Liver
tissue: Liver

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 17473
type: UnificationXref
id: 17473
db: PubChem-compound

Water
type: SmallMolecule
cellular location: Smooth Endoplasmic Reticulum
entity reference: Water

L-Gulonolactone
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: L-Gulonolactone

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Reference/ChEBI CHEBI 16154
type: UnificationXref
id: CHEBI:16154
db: ChEBI

Reference/BioCyc 2,3-diketo-l-gulonate
type: UnificationXref
id: 2,3-diketo-l-gulonate
db: BioCyc

Reference/KEGG Compound C00015
type: UnificationXref
id: C00015
db: KEGG Compound

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Beta-glucuronidase
type: ProteinReference
xref: Reference/UniProt P12265
organism: BiologicalState359

3.1.1.17
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001830/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001902/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Water
right: L-Gulonolactone
spontaneous: false
EC number: 3.1.1.17
left: Hydrogen Ion
left: Gulonic acid
name: Gulonic acid + Hydrogen Ion ↔ L-Gulonolactone + Water
conversion direction: REVERSIBLE

Compound/PW C041003 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: aldehydo-D-glucuronate
stoichiometric coefficient: 1.0

Compound/PW C000143 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

D-glucopyranuronate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 47952
chemical formula: C6H10O7
molecular weight: 194.04265
structure: ChemicalStructure/PW C041002

aldehydo-D-glucuronate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 47953
chemical formula: C6H10O7
molecular weight: 194.04265
structure: ChemicalStructure/PW C041003

Reference/KEGG Compound C00027
type: UnificationXref
id: C00027
db: KEGG Compound

Gulonic acid
type: SmallMolecule
entity reference: Gulonic acid

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Reference/PubChem-compound 54670067
type: UnificationXref
id: 54670067
db: PubChem-compound

Uridine 5'-diphosphate
type: SmallMolecule
cellular location: Smooth Endoplasmic Reticulum
entity reference: Uridine 5'-diphosphate

Endoplasmic Reticulum Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005789

Reference/BioCyc UDP
type: UnificationXref
id: UDP
db: BioCyc

L-gulonolactone oxidase
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: L-gulonolactone oxidase

Compound/PW C001783 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen peroxide
stoichiometric coefficient: 1.0

Water
type: SmallMolecule
entity reference: Water

Reference/BioCyc HYDROGEN-PEROXIDE
type: UnificationXref
id: HYDROGEN-PEROXIDE
db: BioCyc

Uridine diphosphate glucuronic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Uridine diphosphate glucuronic acid
name: SubPathwayOutput

L-xylo-Hexulonolactone
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 73681
xref: Reference/KEGG Compound C03289
xref: Reference/PubChem-compound 6146
chemical formula: C6H8O6
molecular weight: 176.03209
structure: ChemicalStructure/PW C102448

Compound/PW C000746 Smooth Endoplasmic Reticulum /Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine diphosphate glucuronic acid
stoichiometric coefficient: 1.0

Alcohol dehydrogenase [NADP(+)]
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Alcohol dehydrogenase [NADP(+)]

Reference/HMDB HMDB0000935
type: UnificationXref
id: HMDB0000935
db: HMDB

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/CAS 1128-23-0
type: UnificationXref
id: 1128-23-0
db: CAS

Compound/PW C040034 Smooth Endoplasmic Reticulum /Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00167
type: UnificationXref
id: C00167
db: KEGG Compound

Reference/SMPDB SMP0063817
type: UnificationXref
id: SMP0063817
db: SMPDB

Reference/ChEBI CHEBI 73681
type: UnificationXref
id: CHEBI:73681
db: ChEBI

Compound/PW C001420 Smooth Endoplasmic Reticulum /Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/ChemSpider 763
type: UnificationXref
id: 763
db: ChemSpider

ChemicalStructure/PW C001830
type: ChemicalStructure
structure format: SMILES

Uridine 5'-diphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17659
xref: Reference/PubChem-compound 6031
xref: Reference/CAS 58-98-0
xref: Reference/HMDB HMDB0000295
xref: Reference/KEGG Compound C00015
xref: Reference/ChemSpider 5809
xref: Reference/BioCyc UDP
chemical formula: C9H14N2O12P2
molecular weight: 404.0022
structure: ChemicalStructure/PW C000201

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Reference/GENE ONTOLOGY GO 0005790
type: UnificationXref
id: GO:0005790
db: GENE ONTOLOGY

Reference/UniProt P58710
type: UnificationXref
id: P58710
db: UniProt

Reference/PubChem-compound 784
type: UnificationXref
id: 784
db: PubChem-compound

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

ReactionCatalysis130765
type: Catalysis
controller: L-gulonolactone oxidase
controlled: Reaction140691
control type: ACTIVATION

Reaction3057
type: BiochemicalReaction
participant stoichiometry: Compound/PW C041002 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041003 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: aldehydo-D-glucuronate
spontaneous: true
left: D-glucopyranuronate
name: D-glucopyranuronate → aldehydo-D-glucuronate
conversion direction: LEFT_TO_RIGHT

Compound/PW C041002 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-glucopyranuronate
stoichiometric coefficient: 1.0

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

ChemicalStructure/PW C000031
type: ChemicalStructure
structure format: SMILES
structure data: [H][C@@]1(OC(=O)C(O)=C1O)[C@@H](O)CO

Compound/PW C001830/Stoichiometry/1.0
type: Stoichiometry
physical entity: Gulonic acid
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005789
type: UnificationXref
id: GO:0005789
db: GENE ONTOLOGY

Reference/ChemSpider 16522
type: UnificationXref
id: 16522
db: ChemSpider

Regucalcin
type: ProteinReference
xref: Reference/UniProt Q64374

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Compound/PW C041002 Smooth Endoplasmic Reticulum /Stoichiometry/1.0
type: Stoichiometry
physical entity: D-glucopyranuronate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C01040
type: UnificationXref
id: C01040
db: KEGG Compound

Reference/KEGG Compound C00072
type: UnificationXref
id: C00072
db: KEGG Compound

Compound/PW C001830 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Gulonic acid
stoichiometric coefficient: 1.0

Reference/UniProt Q64374
type: UnificationXref
id: Q64374
db: UniProt

Compound/PW C102448 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-xylo-Hexulonolactone
stoichiometric coefficient: 1.0

D-glucopyranuronate
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: D-glucopyranuronate

Reference/HMDB HMDB0000044
type: UnificationXref
id: HMDB0000044
db: HMDB

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/CAS 58-98-0
type: UnificationXref
id: 58-98-0
db: CAS

Compound/PW C001902/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Gulonolactone
stoichiometric coefficient: 1.0

Reference/BioCyc 2-KETO-L-GULONOLACTONE
type: UnificationXref
id: 2-KETO-L-GULONOLACTONE
db: BioCyc

L-Gulonolactone
type: SmallMolecule
entity reference: L-Gulonolactone

Compound/PW C040034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Compound/PW C102448/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-xylo-Hexulonolactone
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/HMDB HMDB0000295
type: UnificationXref
id: HMDB0000295
db: HMDB

Reference/ChemSpider 5809
type: UnificationXref
id: 5809
db: ChemSpider

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

ChemicalStructure/PW C102448
type: ChemicalStructure
structure format: SMILES

3.2.1.31
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000746 Smooth Endoplasmic Reticulum /Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Smooth Endoplasmic Reticulum /Stoichiometry/1.0
participant stoichiometry: Compound/PW C041002 Smooth Endoplasmic Reticulum /Stoichiometry/1.0
participant stoichiometry: Compound/PW C000201 Smooth Endoplasmic Reticulum /Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Smooth Endoplasmic Reticulum /Stoichiometry/1.0
right: Hydrogen Ion
right: Uridine 5'-diphosphate
right: D-glucopyranuronate
spontaneous: false
EC number: 3.2.1.31
left: Uridine diphosphate glucuronic acid
left: Water
name: Uridine diphosphate glucuronic acid + Water → D-glucopyranuronate + Hydrogen Ion + Uridine 5'-diphosphate
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C041003
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

ChemicalStructure/PW C041002
type: ChemicalStructure
structure format: SMILES

Reference/UniProt Q9JII6
type: UnificationXref
id: Q9JII6
db: UniProt

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Smooth Endoplasmic Reticulum
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005790

Reference/UniProt P12265
type: UnificationXref
id: P12265
db: UniProt

Reference/ChemSpider 134243
type: UnificationXref
id: 134243
db: ChemSpider

Uridine diphosphate glucuronic acid
type: SmallMolecule
cellular location: Smooth Endoplasmic Reticulum
entity reference: Uridine diphosphate glucuronic acid

Reference/ChEBI CHEBI 29073
type: UnificationXref
id: CHEBI:29073
db: ChEBI

Reference/ChemSpider 388493
type: UnificationXref
id: 388493
db: ChemSpider

ChemicalStructure/PW C000746
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Reference/HMDB HMDB0003466
type: UnificationXref
id: HMDB0003466
db: HMDB

Reaction140691
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001783 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C102448 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001902 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Hydrogen peroxide
right: L-xylo-Hexulonolactone
spontaneous: false
left: Oxygen
left: L-Gulonolactone
name: L-Gulonolactone + Oxygen → Hydrogen peroxide + L-xylo-Hexulonolactone
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 439373
type: UnificationXref
id: 439373
db: PubChem-compound

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Hydrogen peroxide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003125
xref: Reference/PubChem-compound 784
xref: Reference/ChemSpider 763
xref: Reference/CAS 7722-84-1
xref: Reference/BioCyc HYDROGEN-PEROXIDE
xref: Reference/ChEBI CHEBI 16240
xref: Reference/KEGG Compound C00027
chemical formula: H2O2
molecular weight: 34.005478
structure: ChemicalStructure/PW C001783

NADP
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: NADP

Alcohol dehydrogenase [NADP(+)]
type: ProteinReference
xref: Reference/UniProt Q9JII6
organism: Mus musculus

Reference/ChEBI CHEBI 17659
type: UnificationXref
id: CHEBI:17659
db: ChEBI

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Compound/PW C000031/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ascorbic acid
stoichiometric coefficient: 1.0

ReactionCatalysis101191
type: Catalysis
controller: Beta-glucuronidase
controlled: 3.2.1.31
control type: ACTIVATION

Reference/BioCyc ASCORBATE
type: UnificationXref
id: ASCORBATE
db: BioCyc

Reference/ChEBI CHEBI 47952
type: UnificationXref
id: CHEBI:47952
db: ChEBI

Reference/ChEBI CHEBI 47953
type: UnificationXref
id: CHEBI:47953
db: ChEBI

D-glucopyranuronate
type: SmallMolecule
cellular location: Smooth Endoplasmic Reticulum
entity reference: D-glucopyranuronate