B-cell linker protein
type: Protein
cellular location: Cytoplasm
entity reference: B-cell linker protein

Reference/UniProt Q06187
type: UnificationXref
id: Q06187
db: UniProt

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

B-cell receptor
type: Protein
cellular location: Cytoplasm
entity reference: B-cell receptor

Protein kinase C alpha type
type: Protein
cellular location: Cytoplasm
entity reference: Protein kinase C alpha type

Proto-oncogene vav
type: Protein
cellular location: Cytoplasm
entity reference: Proto-oncogene vav

Reference/UniProt P63000
type: UnificationXref
id: P63000
db: UniProt

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
type: Protein
cellular location: Cytoplasm
entity reference: Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

Nuclear factor of activated T-cells, cytoplasmic 4
type: ProteinReference
xref: Reference/UniProt Q14934
organism: Homo sapiens

direct_interaction
type: InteractionVocabulary

Nuclear factor of activated T-cells, cytoplasmic 3
type: ProteinReference
xref: Reference/UniProt Q12968
organism: Homo sapiens

Dual specificity mitogen-activated protein kinase kinase 1
type: Protein
cellular location: Cytoplasm
entity reference: Dual specificity mitogen-activated protein kinase kinase 1

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/UniProt P40259
type: UnificationXref
id: P40259
db: UniProt

Reference/UniProt P43405
type: UnificationXref
id: P43405
db: UniProt

Compound/PW C097908 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Diacylglycerol
stoichiometric coefficient: 1.0

GRB2/SOS complex
type: Complex
cellular location: Cytoplasm
component: Growth factor receptor-bound protein 2
component: Son of sevenless homolog 1

Reference/SMPDB SMP0069871
type: UnificationXref
id: SMP0069871
db: SMPDB

Reference/UniProt P04049
type: UnificationXref
id: P04049
db: UniProt

Tyrosine-protein kinase BTK
type: ProteinReference
xref: Reference/UniProt Q06187
organism: Homo sapiens

Reference/UniProt P19419
type: UnificationXref
id: P19419
db: UniProt

Mitogen-activated protein kinase kinase kinase 1
type: Protein
cellular location: Cytoplasm
entity reference: Mitogen-activated protein kinase kinase kinase 1

Interaction902
type: MolecularInteraction
interaction type: direct_interaction
name: B-cell antigen receptor complex-associated protein (Homo sapiens) + B-cell receptor + Phosphate activates Tyrosine-protein kinase Lyn
participant: B-cell antigen receptor complex-associated protein (Homo sapiens)_B-cell receptor_Phosphate
participant: Tyrosine-protein kinase Lyn

B-cell antigen receptor complex-associated protein
type: Complex
cellular location: Cytoplasm
component: B-cell antigen receptor complex-associated protein alpha chain
component: B-cell antigen receptor complex-associated protein beta chain

ChemicalStructure/PW C097005
type: ChemicalStructure
structure format: SMILES

Interaction905
type: MolecularInteraction
interaction type: direct_interaction
name: Tyrosine-protein kinase Lyn activates Tyrosine-protein kinase SYK with Phosphate
participant: Tyrosine-protein kinase SYK
participant: Tyrosine-protein kinase Lyn

Interaction907
type: MolecularInteraction
interaction type: direct_interaction
name: Tyrosine-protein kinase Lyn activates B-cell linker protein with Phosphate
participant: Tyrosine-protein kinase Lyn
participant: B-cell linker protein

Water
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Water

Reference/UniProt Q14934
type: UnificationXref
id: Q14934
db: UniProt

Reference/UniProt Q96D31
type: UnificationXref
id: Q96D31
db: UniProt

Reference/UniProt P29353
type: UnificationXref
id: P29353
db: UniProt

Protein kinase C alpha type
type: ProteinReference
xref: Reference/UniProt P17252
organism: Homo sapiens

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
type: ProteinReference
xref: Reference/UniProt Q08209
organism: Homo sapiens

Transcription factor AP-1
type: Protein
cellular location: Cytoplasm
entity reference: Transcription factor AP-1

Reference/UniProt P01100
type: UnificationXref
id: P01100
db: UniProt

Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16595
type: UnificationXref
id: CHEBI:16595
db: ChEBI

Interaction919
type: MolecularInteraction
interaction type: direct_interaction
name: Tyrosine-protein kinase SYK with Phosphate activates B-cell linker protein with Phosphate
participant: Tyrosine-protein kinase SYK
participant: B-cell linker protein

B-cell receptor
type: ProteinReference
organism: Homo sapiens

Calmodulin-1
type: ProteinReference
xref: Reference/UniProt P0DP23
organism: Homo sapiens

Reference/CAS 85166-31-0
type: UnificationXref
id: 85166-31-0
db: CAS

Calmodulin-2
type: ProteinReference
xref: Reference/UniProt P0DP24
organism: Homo sapiens

Calmodulin-3
type: ProteinReference
xref: Reference/UniProt P0DP25
organism: Homo sapiens

Reference/UniProt Q12968
type: UnificationXref
id: Q12968
db: UniProt

ChemicalStructure/PW C097908
type: ChemicalStructure
structure format: SMILES

Nuclear factor of activated T-cells
type: Complex
cellular location: Cytoplasm
component: Nuclear factor of activated T-cells, cytoplasmic 4
component: Nuclear factor of activated T-cells, cytoplasmic 1
component: Nuclear factor of activated T-cells, cytoplasmic 3
component: Nuclear factor of activated T-cells, cytoplasmic 2

Reference/UniProt P01112
type: UnificationXref
id: P01112
db: UniProt

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: O4P
molecular weight: 94.95342
structure: ChemicalStructure/PW C001104

Interaction922
type: MolecularInteraction
interaction type: direct_interaction
name: Tyrosine-protein kinase SYK with Phosphate activates Proto-oncogene vav with Phosphate
participant: Tyrosine-protein kinase SYK
participant: Proto-oncogene vav

Interaction924
type: MolecularInteraction
interaction type: direct_interaction
name: SHC-transforming protein 1 with phosphorylation activates GRB2/SOS complex
participant: GRB2/SOS complex
participant: SHC-transforming protein 1

Interaction923
type: MolecularInteraction
interaction type: direct_interaction
name: Tyrosine-protein kinase SYK with Phosphate activates SHC-transforming protein 1 with phosphorylation
participant: Tyrosine-protein kinase SYK
participant: SHC-transforming protein 1

Interaction926
type: MolecularInteraction
interaction type: direct_interaction
name: Tyrosine-protein kinase SYK with Phosphate activates Tyrosine-protein kinase BTK with Phosphate
participant: Tyrosine-protein kinase SYK
participant: Tyrosine-protein kinase BTK

Interaction925
type: MolecularInteraction
interaction type: direct_interaction
name: GRB2/SOS complex activates GTPase HRas with GTP
participant: GRB2/SOS complex
participant: GTPase HRas

Interaction928
type: MolecularInteraction
interaction type: direct_interaction
name: Diacylglycerol activates Protein kinase C complex
participant: Protein kinase C complex
participant: Diacylglycerol

Interaction807
type: MolecularInteraction
interaction type: direct_interaction
name: Active Dual specificity mitogen-activated protein kinase kinase 1 activates Mitogen-activated protein kinase 3 with Phosphate
participant: Mitogen-activated protein kinase 3
participant: Dual specificity mitogen-activated protein kinase kinase 1

Interaction927
type: MolecularInteraction
interaction type: direct_interaction
name: Tyrosine-protein kinase SYK with Phosphate activates 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 with phosphate
participant: Tyrosine-protein kinase SYK
participant: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Interaction929
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium activates Protein kinase C complex
participant: Calcium
participant: Protein kinase C complex

Proto-oncogene c-Fos
type: Protein
cellular location: Cytoplasm
entity reference: Proto-oncogene c-Fos

Reference/UniProt Q8WV28
type: UnificationXref
id: Q8WV28
db: UniProt

Reference/UniProt P17252
type: UnificationXref
id: P17252
db: UniProt

Proto-oncogene vav
type: ProteinReference
xref: Reference/UniProt P15498
organism: Homo sapiens

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: Reference/UniProt P63000
organism: Homo sapiens

Tyrosine-protein kinase SYK
type: ProteinReference
xref: Reference/UniProt P43405
organism: Homo sapiens

Interaction931
type: MolecularInteraction
interaction type: direct_interaction
name: GTPase HRas with GTP activates RAF proto-oncogene serine/threonine-protein kinase with Phosphate
participant: RAF proto-oncogene serine/threonine-protein kinase
participant: GTPase HRas

Interaction930
type: MolecularInteraction
interaction type: direct_interaction
name: Protein kinase C complex activates ETS domain-containing protein Elk-1
participant: Protein kinase C complex
participant: ETS domain-containing protein Elk-1

Interaction933
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase 3 with Phosphate activates FOS,JUN Complex
participant: Mitogen-activated protein kinase 3
participant: FOS,JUN Complex

Interaction932
type: MolecularInteraction
interaction type: direct_interaction
name: RAF proto-oncogene serine/threonine-protein kinase with Phosphate activates Active Dual specificity mitogen-activated protein kinase kinase 1
participant: RAF proto-oncogene serine/threonine-protein kinase
participant: Dual specificity mitogen-activated protein kinase kinase 1

Growth factor receptor-bound protein 2
type: ProteinReference
xref: Reference/UniProt P62993
organism: Homo sapiens

Interaction935
type: MolecularInteraction
interaction type: direct_interaction
name: Ras-related C3 botulinum toxin substrate 1 activates Mitogen-activated protein kinase kinase kinase 1 without Magnesium
participant: Mitogen-activated protein kinase kinase kinase 1
participant: Ras-related C3 botulinum toxin substrate 1

Interaction934
type: MolecularInteraction
interaction type: direct_interaction
name: Proto-oncogene vav with Phosphate activates Ras-related C3 botulinum toxin substrate 1
participant: Proto-oncogene vav
participant: Ras-related C3 botulinum toxin substrate 1

Proto-oncogene c-Fos
type: ProteinReference
xref: Reference/UniProt P01100
organism: Homo sapiens

Interaction937
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase kinase kinase 1 without Magnesium activates Mitogen-activated protein kinase 14 with Magnesium
participant: Calcium release-activated calcium channel protein 1
participant: Mitogen-activated protein kinase kinase kinase 1

Interaction936
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase kinase kinase 1 without Magnesium activates Mitogen-activated protein kinase 8 without Magnesium
participant: Mitogen-activated protein kinase kinase kinase 1
participant: Mitogen-activated protein kinase 8

Interaction938
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase 14 with Magnesium activates FOS,JUN Complex
participant: Calcium release-activated calcium channel protein 1
participant: FOS,JUN Complex

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])([O-])=O

Reference/PubChem-compound 6026790
type: UnificationXref
id: 6026790
db: PubChem-compound

Inositol 1,4,5-trisphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Inositol 1,4,5-trisphosphate

Reference/BioCyc inositol 1,4,5-trisphosphate
type: UnificationXref
id: inositol_1,4,5-trisphosphate
db: BioCyc

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Calmodulin(123)
type: Complex
cellular location: Cytoplasm
component: Calmodulin-2
component: Calmodulin-1
component: Calmodulin-3

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Mitogen-activated protein kinase 8
type: Protein
cellular location: Cytoplasm
entity reference: Mitogen-activated protein kinase 8

Reference/UniProt Q07889
type: UnificationXref
id: Q07889
db: UniProt

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: Reference/UniProt P19174
organism: Homo sapiens

Reference/ChemSpider 388562
type: UnificationXref
id: 388562
db: ChemSpider

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

Interaction706
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase 8 without Magnesium activates FOS,JUN Complex
participant: FOS,JUN Complex
participant: Mitogen-activated protein kinase 8

Reference/UniProt P15498
type: UnificationXref
id: P15498
db: UniProt

Growth factor receptor-bound protein 2
type: Protein
cellular location: Cytoplasm
entity reference: Growth factor receptor-bound protein 2

Reference/PubChem-compound 24742074
type: UnificationXref
id: 24742074
db: PubChem-compound

Phosphatidylinositol 4,5-bisphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphatidylinositol 4,5-bisphosphate

Nuclear factor of activated T-cells, cytoplasmic 3
type: Protein
cellular location: Cytoplasm
entity reference: Nuclear factor of activated T-cells, cytoplasmic 3

GTPase HRas
type: ProteinReference
xref: Reference/UniProt P01112
organism: Homo sapiens

Son of sevenless homolog 1
type: Protein
cellular location: Cytoplasm
entity reference: Son of sevenless homolog 1

Reference/UniProt P19174
type: UnificationXref
id: P19174
db: UniProt

Nuclear factor of activated T-cells (Homo sapiens)_Phosphate
type: Complex
component stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
component stoichiometry: ProteinComplex/7932 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Nuclear factor of activated T-cells
component: Phosphate

Nuclear factor of activated T-cells, cytoplasmic 4
type: Protein
cellular location: Cytoplasm
entity reference: Nuclear factor of activated T-cells, cytoplasmic 4

Tyrosine-protein kinase SYK
type: Protein
cellular location: Cytoplasm
entity reference: Tyrosine-protein kinase SYK

Son of sevenless homolog 1
type: ProteinReference
xref: Reference/UniProt Q07889
organism: Homo sapiens

Interaction832
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium activates Calmodulin(123)
participant: Calmodulin(123)
participant: Calcium

Diacylglycerol
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Diacylglycerol

Interaction833
type: MolecularInteraction
interaction type: direct_interaction
name: Calmodulin(123) activates protein phosphatase 3
participant: Calmodulin(123)
participant: protein phosphatase 3

Interaction836
type: MolecularInteraction
interaction type: direct_interaction
name: protein phosphatase 3 activates Nuclear factor of activated T-cells (Homo sapiens) + Phosphate
participant: Nuclear factor of activated T-cells (Homo sapiens)_Phosphate
participant: protein phosphatase 3

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Calmodulin-1
type: Protein
cellular location: Cytoplasm
entity reference: Calmodulin-1

Reference/UniProt Q02750
type: UnificationXref
id: Q02750
db: UniProt

B-cell linker protein
type: ProteinReference
xref: Reference/UniProt Q8WV28
organism: Homo sapiens

Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

protein phosphatase 3
type: Complex
cellular location: Cytoplasm
component: Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
component: Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
component: Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

BoundComplex/91 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Nuclear factor of activated T-cells (Homo sapiens)_Phosphate
stoichiometric coefficient: 1.0

GTPase HRas
type: ProteinReference
xref: Reference/UniProt P01112
organism: Homo sapiens

Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
type: Protein
cellular location: Cytoplasm
entity reference: Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
type: Protein
cellular location: Cytoplasm
entity reference: Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

Calcium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Calcium

Reference/UniProt P0DP23
type: UnificationXref
id: P0DP23
db: UniProt

Phosphatidylinositol 4,5-bisphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24742074
chemical formula: C47H80O19P3
molecular weight: 1041.4507
structure: ChemicalStructure/PW C097005

Tyrosine-protein kinase BTK
type: Protein
cellular location: Cytoplasm
entity reference: Tyrosine-protein kinase BTK

Reference/UniProt P0DP24
type: UnificationXref
id: P0DP24
db: UniProt

Reference/UniProt P11912
type: UnificationXref
id: P11912
db: UniProt

Reference/UniProt P0DP25
type: UnificationXref
id: P0DP25
db: UniProt

Reference/UniProt P27361
type: UnificationXref
id: P27361
db: UniProt

RAF proto-oncogene serine/threonine-protein kinase
type: Protein
cellular location: Cytoplasm
entity reference: RAF proto-oncogene serine/threonine-protein kinase

Calcium release-activated calcium channel protein 1
type: Protein
entity reference: Calcium release-activated calcium channel protein 1

Inositol 1,4,5-trisphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001498
xref: Reference/PubChem-compound 439456
xref: Reference/CAS 85166-31-0
xref: Reference/BioCyc inositol 1,4,5-trisphosphate
xref: Reference/KEGG Compound C01245
xref: Reference/ChEBI CHEBI 16595
xref: Reference/ChemSpider 388562
chemical formula: C6H15O15P3
molecular weight: 419.96237
structure: ChemicalStructure/PW C001155

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Nuclear factor of activated T-cells, cytoplasmic 2
type: Protein
cellular location: Cytoplasm
entity reference: Nuclear factor of activated T-cells, cytoplasmic 2

Protein kinase C beta type
type: ProteinReference
xref: Reference/UniProt P05771
organism: Homo sapiens

Protein/238 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
stoichiometric coefficient: 1.0

Nuclear factor of activated T-cells, cytoplasmic 1
type: Protein
cellular location: Cytoplasm
entity reference: Nuclear factor of activated T-cells, cytoplasmic 1

ProteinComplex/7979 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: B-cell antigen receptor complex-associated protein
stoichiometric coefficient: 1.0

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Reference/KEGG Compound C01245
type: UnificationXref
id: C01245
db: KEGG Compound

Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Calcium
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Calcium

Reference/UniProt P07948
type: UnificationXref
id: P07948
db: UniProt

Compound/PW C001155 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate
stoichiometric coefficient: 1.0

TransportCatalysis996
type: Catalysis
controller: Calcium release-activated calcium channel protein 1
controlled: Transport3328
control type: ACTIVATION

Calmodulin-3
type: Protein
cellular location: Cytoplasm
entity reference: Calmodulin-3

Reference/UniProt P05771
type: UnificationXref
id: P05771
db: UniProt

Reference/UniProt P05412
type: UnificationXref
id: P05412
db: UniProt

Diacylglycerol
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6026790
chemical formula: C37H70O5
molecular weight: 594.52234
structure: ChemicalStructure/PW C097908

FOS,JUN Complex
type: Complex
cellular location: Cytoplasm
component: Transcription factor AP-1
component: Proto-oncogene c-Fos

Reference/UniProt O95644
type: UnificationXref
id: O95644
db: UniProt

ChemicalStructure/PW C001155
type: ChemicalStructure
structure format: SMILES

Calmodulin-2
type: Protein
cellular location: Cytoplasm
entity reference: Calmodulin-2

Tyrosine-protein kinase Lyn
type: Protein
cellular location: Cytoplasm
entity reference: Tyrosine-protein kinase Lyn

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Ras-related C3 botulinum toxin substrate 1
type: Protein
cellular location: Cytoplasm
entity reference: Ras-related C3 botulinum toxin substrate 1

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

ETS domain-containing protein Elk-1
type: ProteinReference
xref: Reference/UniProt P19419
organism: Homo sapiens

B-cell antigen receptor complex-associated protein alpha chain
type: Protein
cellular location: Cytoplasm
entity reference: B-cell antigen receptor complex-associated protein alpha chain

Protein/Generic440 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: B-cell receptor
stoichiometric coefficient: 1.0

Reaction115852
type: BiochemicalReaction
participant stoichiometry: Compound/PW C097005 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001155 Cytoplasm/Stoichiometry/1.0
right: Inositol 1,4,5-trisphosphate
spontaneous: false
left: Phosphatidylinositol 4,5-bisphosphate
name: Phosphatidylinositol 4,5-bisphosphate → Inositol 1,4,5-trisphosphate
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 439456
type: UnificationXref
id: 439456
db: PubChem-compound

Reaction115976
type: BiochemicalReaction
participant stoichiometry: BoundComplex/91 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/7932 Cytoplasm/Stoichiometry/1.0
right: Nuclear factor of activated T-cells
right: Phosphate
spontaneous: false
left: Nuclear factor of activated T-cells (Homo sapiens)_Phosphate
name: Nuclear factor of activated T-cells (Homo sapiens) + Phosphate → Nuclear factor of activated T-cells + Phosphate
conversion direction: LEFT_TO_RIGHT

ProteinComplex/7932 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Nuclear factor of activated T-cells
stoichiometric coefficient: 1.0

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: Reference/UniProt Q02750
organism: Homo sapiens

Mitogen-activated protein kinase kinase kinase 1
type: ProteinReference
xref: Reference/UniProt Q13233
organism: Homo sapiens

Mitogen-activated protein kinase 3
type: ProteinReference
xref: Reference/UniProt P27361
organism: Homo sapiens

Tyrosine-protein kinase Lyn
type: ProteinReference
xref: Reference/UniProt P07948
organism: Homo sapiens

Calcium release-activated calcium channel protein 1
type: ProteinReference
xref: Reference/UniProt Q96D31

Reference/HMDB HMDB0001498
type: UnificationXref
id: HMDB0001498
db: HMDB

GTPase HRas
type: Protein
cellular location: Cytoplasm
entity reference: GTPase HRas

Reaction122705
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C097005 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Protein/238 Cytoplasm/Stoichiometry/1.0
right: Phosphatidylinositol 4,5-bisphosphate
spontaneous: false
left: Water
left: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 with phosphate + Water → Phosphatidylinositol 4,5-bisphosphate
conversion direction: LEFT_TO_RIGHT

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/UniProt Q13233
type: UnificationXref
id: Q13233
db: UniProt

Protein kinase C complex
type: Complex
cellular location: Cytoplasm
component: Protein kinase C beta type
component: Protein kinase C alpha type

Reference/UniProt P48454
type: UnificationXref
id: P48454
db: UniProt

ETS domain-containing protein Elk-1
type: Protein
cellular location: Cytoplasm
entity reference: ETS domain-containing protein Elk-1

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

SHC-transforming protein 1
type: ProteinReference
xref: Reference/UniProt P29353
organism: Homo sapiens

Reference/UniProt P62993
type: UnificationXref
id: P62993
db: UniProt

Reference/UniProt Q08209
type: UnificationXref
id: Q08209
db: UniProt

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Reference/UniProt P45983
type: UnificationXref
id: P45983
db: UniProt

Reference/UniProt P16298
type: UnificationXref
id: P16298
db: UniProt

BCR Signaling Pathway
type: Pathway
pathway order: PathwayInteraction/669
pathway order: PathwayInteraction/922
pathway order: PathwayEnzymeReaction/1341965
pathway order: PathwayInteraction/923
pathway order: PathwayInteraction/902
pathway order: PathwayInteraction/924
pathway order: PathwayInteraction/925
pathway order: PathwayInteraction/926
pathway order: PathwayInteraction/706
pathway order: PathwayInteraction/905
pathway order: PathwayInteraction/927
pathway order: PathwayInteraction/928
pathway order: PathwayInteraction/807
pathway order: PathwayInteraction/907
pathway order: PathwayInteraction/929
pathway order: PathwayEnzymeReaction/1343198
pathway order: PathwayEnzymeReaction/1342166
pathway order: PathwayTransport/1342637
pathway order: PathwayInteraction/930
pathway order: PathwayInteraction/832
pathway order: PathwayInteraction/931
pathway order: PathwayInteraction/833
pathway order: PathwayInteraction/932
pathway order: PathwayInteraction/933
pathway order: PathwayInteraction/934
pathway order: PathwayInteraction/836
pathway order: PathwayInteraction/935
pathway order: PathwayInteraction/936
pathway order: PathwayInteraction/937
pathway order: PathwayInteraction/938
pathway order: PathwayInteraction/919
pathway order: PathwayEnzymeReaction/1342250
pathway component: Interaction832
pathway component: Interaction931
pathway component: Interaction930
pathway component: Interaction933
pathway component: Interaction833
pathway component: Interaction932
pathway component: Interaction836
pathway component: Interaction935
pathway component: Interaction934
pathway component: Interaction937
pathway component: Interaction936
pathway component: Reaction115852
pathway component: Interaction938
pathway component: Interaction919
pathway component: TransportCatalysis996
pathway component: Reaction115976
pathway component: Interaction669
pathway component: Interaction922
pathway component: Transport3328
pathway component: Interaction902
pathway component: Interaction924
pathway component: Interaction923
pathway component: Interaction926
pathway component: Interaction706
pathway component: Interaction925
pathway component: Interaction928
pathway component: Interaction807
pathway component: Interaction905
pathway component: Interaction927
pathway component: Reaction122705
pathway component: Interaction907
pathway component: Interaction929
pathway component: Reaction115846
xref: Reference/SMPDB SMP0069871
xref: Reference/PathWhiz PW070885
organism: Homo sapiens

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

Reference/PathWhiz PW070885
type: UnificationXref
id: PW070885
db: PathWhiz

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

B-cell antigen receptor complex-associated protein beta chain
type: ProteinReference
xref: Reference/UniProt P40259
organism: Homo sapiens

B-cell antigen receptor complex-associated protein (Homo sapiens)_B-cell receptor_Phosphate
type: Complex
component stoichiometry: Protein/Generic440 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
component stoichiometry: ProteinComplex/7979 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: B-cell receptor
component: Phosphate
component: B-cell antigen receptor complex-associated protein

B-cell antigen receptor complex-associated protein alpha chain
type: ProteinReference
xref: Reference/UniProt P11912
organism: Homo sapiens

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Interaction669
type: MolecularInteraction
interaction type: direct_interaction
name: GTPase HRas with GTP activates GTPase HRas with GDP, Phosphate
participant: GTPase HRas

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
xref: Reference/UniProt P04049
organism: Homo sapiens

Phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphate

Protein kinase C beta type
type: Protein
cellular location: Cytoplasm
entity reference: Protein kinase C beta type

Compound/PW C097005 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol 4,5-bisphosphate
stoichiometric coefficient: 1.0

Reaction115846
type: BiochemicalReaction
participant stoichiometry: Compound/PW C097908 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C097005 Cytoplasm/Stoichiometry/1.0
right: Diacylglycerol
spontaneous: false
left: Phosphatidylinositol 4,5-bisphosphate
name: Phosphatidylinositol 4,5-bisphosphate → Diacylglycerol
conversion direction: LEFT_TO_RIGHT

B-cell antigen receptor complex-associated protein beta chain
type: Protein
cellular location: Cytoplasm
entity reference: B-cell antigen receptor complex-associated protein beta chain

Nuclear factor of activated T-cells, cytoplasmic 2
type: ProteinReference
xref: Reference/UniProt Q13469
organism: Homo sapiens

Nuclear factor of activated T-cells, cytoplasmic 1
type: ProteinReference
xref: Reference/UniProt O95644
organism: Homo sapiens

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: Protein
cellular location: Cytoplasm
entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Mitogen-activated protein kinase 8
type: ProteinReference
xref: Reference/UniProt P45983
organism: Homo sapiens

Transcription factor AP-1
type: ProteinReference
xref: Reference/UniProt P05412
organism: Homo sapiens

GTPase HRas
type: Protein
cellular location: Cytoplasm
entity reference: GTPase HRas

SHC-transforming protein 1
type: Protein
cellular location: Cytoplasm
entity reference: SHC-transforming protein 1

Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
type: ProteinReference
xref: Reference/UniProt P16298
organism: Homo sapiens

Transport3328
type: Transport
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytoplasm
conversion direction: LEFT_TO_RIGHT

Calcium release-activated calcium channel protein 1
type: Protein
cellular location: Cytoplasm
entity reference: Calcium release-activated calcium channel protein 1

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
type: ProteinReference
xref: Reference/UniProt P48454
organism: Homo sapiens

Mitogen-activated protein kinase 3
type: Protein
cellular location: Cytoplasm
entity reference: Mitogen-activated protein kinase 3

Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/UniProt Q13469
type: UnificationXref
id: Q13469
db: UniProt