Reference/UniProt Q29RZ0
type: UnificationXref
id: Q29RZ0
db: UniProt

Reference/ChemSpider 388357
type: UnificationXref
id: 388357
db: ChemSpider

Butyric acid
type: SmallMoleculeReference
xref: Reference/CAS 107-92-6
xref: Reference/ChemSpider 259
xref: Reference/HMDB HMDB0000039
xref: Reference/ChEBI CHEBI 30772
xref: Reference/KEGG Compound C00246
xref: Reference/PubChem-compound 264
chemical formula: C4H8O2
molecular weight: 88.05243
structure: ChemicalStructure/PW C000028

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

Reference/PubChem-compound 439161
type: UnificationXref
id: 439161
db: PubChem-compound

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Adenosine triphosphate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Adenosine triphosphate

Compound/PW C000174 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinic acid
stoichiometric coefficient: 1.0

Butyric acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Butyric acid

Reference/ChemSpider 388353
type: UnificationXref
id: 388353
db: ChemSpider

Reference/ChemSpider 259
type: UnificationXref
id: 259
db: ChemSpider

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

Reference/TAXONOMY 9913
type: UnificationXref
id: 9913
db: TAXONOMY

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

Reference/ChEBI CHEBI 57371
type: UnificationXref
id: CHEBI:57371
db: ChEBI

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Protein/15184 Mitochondrion/Stoichiometry/4.0
type: Stoichiometry
physical entity: Short-chain specific acyl-CoA dehydrogenase, mitochondrial
stoichiometric coefficient: 4.0

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/CAS 102680-35-3
type: UnificationXref
id: 102680-35-3
db: CAS

Acetoacetic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15344
xref: Reference/HMDB HMDB0000060
xref: Reference/BioCyc 3-KETOBUTYRATE
xref: Reference/KEGG Compound C00164
xref: Reference/PubChem-compound 96
xref: Reference/CAS 541-50-4
xref: Reference/ChemSpider 94
chemical formula: C4H6O3
molecular weight: 102.03169
structure: ChemicalStructure/PW C000042

Compound/PW C000856 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Butyryl-CoA
stoichiometric coefficient: 1.0

Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
type: Complex
component stoichiometry: Protein/15401 Mitochondrial Matrix/Stoichiometry/2.0
cellular location: Mitochondrial Matrix
component: Hydroxyacyl-CoA dehydrogenase

Reference/CAS 1553-55-5
type: UnificationXref
id: 1553-55-5
db: CAS

Reference/ChEBI CHEBI 15380
type: UnificationXref
id: CHEBI:15380
db: ChEBI

Reference/PubChem-compound 5280381
type: UnificationXref
id: 5280381
db: PubChem-compound

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Succinyl-CoA
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00091
xref: Reference/CAS 604-98-8
xref: Reference/ChemSpider 388307
xref: Reference/PubChem-compound 439161
xref: Reference/ChEBI CHEBI 15380
xref: Reference/BioCyc 3-METHYLBENZYLSUCCINYL-COA
xref: Reference/HMDB HMDB0001022
chemical formula: C25H40N7O19P3S
molecular weight: 867.1312
structure: ChemicalStructure/PW C000808

Reference/PubChem-compound 265
type: UnificationXref
id: 265
db: PubChem-compound

Reference/KEGG Compound C00332
type: UnificationXref
id: C00332
db: KEGG Compound

Reference/PubChem-compound 264
type: UnificationXref
id: 264
db: PubChem-compound

ReactionCatalysis135928
type: Catalysis
controller: Acetyl-CoA acetyltransferase, mitochondrial
controlled: 2.3.1.9
control type: ACTIVATION

ReactionCatalysis135927
type: Catalysis
controller: Enoyl-CoA hydratase, mitochondrial
controlled: 4.2.1.17
control type: ACTIVATION

Reference/PubChem-compound 440045
type: UnificationXref
id: 440045
db: PubChem-compound

Crotonoyl-CoA
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00877
xref: Reference/HMDB HMDB0002009
xref: Reference/PubChem-compound 5280381
xref: Reference/CAS 102680-35-3
xref: Reference/BioCyc CPD-1083
xref: Reference/ChEBI CHEBI 15473
xref: Reference/ChemSpider 4444072
chemical formula: C25H40N7O17P3S
molecular weight: 835.1414
structure: ChemicalStructure/PW C001345

Reference/UniProt F1MTP3
type: UnificationXref
id: F1MTP3
db: UniProt

Reduced electron-transfer flavoprotein
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Reduced electron-transfer flavoprotein

Butyryl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Butyryl-CoA

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Reference/HMDB HMDB0001088
type: UnificationXref
id: HMDB0001088
db: HMDB

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

Reference/ChEBI CHEBI 30772
type: UnificationXref
id: CHEBI:30772
db: ChEBI

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reference/CAS 107-92-6
type: UnificationXref
id: 107-92-6
db: CAS

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

Compound/PW C001063 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Hydroxy-3-methylglutaryl-CoA
stoichiometric coefficient: 1.0

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Reference/ChemSpider 260
type: UnificationXref
id: 260
db: ChemSpider

Mitochondrion
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005739

Succinyl-CoA:3-ketoacid-coenzyme A transferase
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Succinyl-CoA:3-ketoacid-coenzyme A transferase

ChemicalStructure/PW C000808
type: ChemicalStructure
structure format: SMILES

Hydroxymethylglutaryl-CoA lyase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q148J2
organism: Bos taurus

Succinyl-CoA:3-ketoacid-coenzyme A transferase
type: ProteinReference
xref: Reference/UniProt F1MTP3
organism: Bos taurus

electron-transfer flavoprotein
type: SmallMolecule
cellular location: Mitochondrion
entity reference: electron-transfer flavoprotein

Reference/KEGG Compound C00356
type: UnificationXref
id: C00356
db: KEGG Compound

Reference/ChEBI CHEBI 5086
type: UnificationXref
id: CHEBI:5086
db: ChEBI

Short-chain specific acyl-CoA dehydrogenase, mitochondrial
type: Complex
component stoichiometry: Protein/15184 Mitochondrion/Stoichiometry/4.0
cellular location: Mitochondrion
component: Short-chain specific acyl-CoA dehydrogenase, mitochondrial

Reference/ChemSpider 4444072
type: UnificationXref
id: 4444072
db: ChemSpider

Reference/BioCyc SUC
type: UnificationXref
id: SUC
db: BioCyc

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

Adenosine monophosphate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Adenosine monophosphate

Compound/Generic70 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Reduced electron-transfer flavoprotein
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001345
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 94
type: UnificationXref
id: 94
db: ChemSpider

Acyl-coenzyme A synthetase ACSM1, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q9XT43
organism: Bos taurus

Transport7863
type: Transport
participant stoichiometry: Compound/PW C000028 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000028 Mitochondrial Matrix/Stoichiometry/1.0
right: Butyric acid
spontaneous: false
left: Butyric acid
name: Butyric acid (→) Transport: Bos taurus, Cell, Cytoplasm to Bos taurus, Cell, Mitochondrial Matrix
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

NADH
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: NADH

Reference/BioCyc CPD-1083
type: UnificationXref
id: CPD-1083
db: BioCyc

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/KEGG Compound C00246
type: UnificationXref
id: C00246
db: KEGG Compound

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

ReactionCatalysis135923
type: Catalysis
controller: Short-chain specific acyl-CoA dehydrogenase, mitochondrial
controlled: 1.3.8.1
control type: ACTIVATION

Compound/PW C000028 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Butyric acid
stoichiometric coefficient: 1.0

SubPathwayInteraction108150
type: Interaction
name: SubPathwayReaction
name: SubPathway108150Reaction
participant: Acetoacetic acid

Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/2.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 2.0

Reference/GENE ONTOLOGY GO 0005759
type: UnificationXref
id: GO:0005759
db: GENE ONTOLOGY

Pyrophosphate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Pyrophosphate

Coenzyme A
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Coenzyme A

Hydroxymethylglutaryl-CoA lyase, mitochondrial
type: Complex
component stoichiometry: Protein/15413 Mitochondrial Matrix/Stoichiometry/2.0
cellular location: Mitochondrial Matrix
component: Hydroxymethylglutaryl-CoA lyase, mitochondrial

ChemicalStructure/PW C000904
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 15741
type: UnificationXref
id: CHEBI:15741
db: ChEBI

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H28N7O14P2
molecular weight: 664.11694
structure: ChemicalStructure/PW C000721

Enoyl-CoA hydratase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Enoyl-CoA hydratase, mitochondrial

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Reference/KEGG Compound C00136
type: UnificationXref
id: C00136
db: KEGG Compound

Reference/PubChem-compound 1110
type: UnificationXref
id: 1110
db: PubChem-compound

Reference/PathWhiz PW088204
type: UnificationXref
id: PW088204
db: PathWhiz

Hydrogen Ion
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Hydrogen Ion

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: O7P2
molecular weight: 173.91193
structure: ChemicalStructure/PW C000170

Acetoacetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETOACETYL-COA
xref: Reference/PubChem-compound 439214
xref: Reference/ChEBI CHEBI 15345
xref: Reference/CAS 1420-36-6
xref: Reference/HMDB HMDB0001484
xref: Reference/KEGG Compound C00332
xref: Reference/ChemSpider 388353
chemical formula: C25H40N7O18P3S
molecular weight: 851.13635
structure: ChemicalStructure/PW C001142

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reference/BioCyc 3-HYDROXY-3-METHYL-GLUTARYL-COA
type: UnificationXref
id: 3-HYDROXY-3-METHYL-GLUTARYL-COA
db: BioCyc

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/UniProt Q2KIE6
type: UnificationXref
id: Q2KIE6
db: UniProt

Succinic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000254
xref: Reference/CAS 110-15-6
xref: Reference/ChEBI CHEBI 15741
xref: Reference/KEGG Compound C00042
xref: Reference/ChemSpider 1078
xref: Reference/PubChem-compound 1110
xref: Reference/BioCyc SUC
chemical formula: C4H6O4
molecular weight: 118.02661
structure: ChemicalStructure/PW C000174

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Butyryl-CoA
type: SmallMoleculeReference
xref: Reference/CAS 2140-48-9
xref: Reference/ChEBI CHEBI 57371
xref: Reference/ChemSpider 260
xref: Reference/PubChem-compound 265
xref: Reference/KEGG Compound C00136
xref: Reference/BioCyc CPD-12174
xref: Reference/HMDB HMDB0001088
chemical formula: C25H42N7O17P3S
molecular weight: 837.15704
structure: ChemicalStructure/PW C000856

Reference/ChemSpider 388307
type: UnificationXref
id: 388307
db: ChemSpider

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

Compound/PW C000028 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Butyric acid
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005739
type: UnificationXref
id: GO:0005739
db: GENE ONTOLOGY

Reference/SMPDB SMP0000071
type: UnificationXref
id: SMP0000071
db: SMPDB

Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Acetyl-CoA acetyltransferase, mitochondrial
type: Complex
component stoichiometry: Protein/15185 Mitochondrial Matrix/Stoichiometry/4.0
cellular location: Mitochondrial Matrix
component: Acetyl-CoA acetyltransferase, mitochondrial

Compound/PW C000170 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/BioCyc 3-KETOBUTYRATE
type: UnificationXref
id: 3-KETOBUTYRATE
db: BioCyc

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

electron-transfer flavoprotein
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 5086

Compound/PW C000414 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/BioCyc 2-METHYL-3-HYDROXY-BUTYRYL-COA
type: UnificationXref
id: 2-METHYL-3-HYDROXY-BUTYRYL-COA
db: BioCyc

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reduced electron-transfer flavoprotein
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 5086

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

Protein/15411 Mitochondrial Matrix/Stoichiometry/2.0
type: Stoichiometry
physical entity: Succinyl-CoA:3-ketoacid-coenzyme A transferase
stoichiometric coefficient: 2.0

Reference/HMDB HMDB0000254
type: UnificationXref
id: HMDB0000254
db: HMDB

Reference/CAS 2871-66-1
type: UnificationXref
id: 2871-66-1
db: CAS

ChemicalStructure/PW C001142
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000174
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(O)=O

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

Protein/15185 Mitochondrial Matrix/Stoichiometry/4.0
type: Stoichiometry
physical entity: Acetyl-CoA acetyltransferase, mitochondrial
stoichiometric coefficient: 4.0

Mitochondrial Matrix
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005759

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])(=O)OP([O-])([O-])=O

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Acetyl-CoA acetyltransferase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q29RZ0
organism: Bos taurus

Reference/KEGG Compound C00164
type: UnificationXref
id: C00164
db: KEGG Compound

Reference/KEGG Compound C00042
type: UnificationXref
id: C00042
db: KEGG Compound

Short-chain specific acyl-CoA dehydrogenase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q3ZBF6
organism: Bos taurus

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

Reference/ChemSpider 1078
type: UnificationXref
id: 1078
db: ChemSpider

Reference/BioCyc CPD-12174
type: UnificationXref
id: CPD-12174
db: BioCyc

Reference/ChEBI CHEBI 15452
type: UnificationXref
id: CHEBI:15452
db: ChEBI

Compound/PW C001142 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetoacetyl-CoA
stoichiometric coefficient: 1.0

Reference/ChemSpider 389056
type: UnificationXref
id: 389056
db: ChemSpider

ChemicalStructure/PW C000856
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C03561
type: UnificationXref
id: C03561
db: KEGG Compound

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Reference/CAS 604-98-8
type: UnificationXref
id: 604-98-8
db: CAS

Bos taurus
type: BioSource
xref: Reference/TAXONOMY 9913

Reference/UniProt Q148J2
type: UnificationXref
id: Q148J2
db: UniProt

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

3-Hydroxybutyryl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: 3-Hydroxybutyryl-CoA

Reference/BioCyc ACETOACETYL-COA
type: UnificationXref
id: ACETOACETYL-COA
db: BioCyc

Succinyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Succinyl-CoA

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000028
type: ChemicalStructure
structure format: SMILES
structure data: CCCC(O)=O

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Crotonoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Crotonoyl-CoA

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

3-Hydroxy-3-methylglutaryl-CoA
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15467
xref: Reference/ChemSpider 388357
xref: Reference/CAS 1553-55-5
xref: Reference/BioCyc 3-HYDROXY-3-METHYL-GLUTARYL-COA
xref: Reference/KEGG Compound C00356
xref: Reference/HMDB HMDB0001375
xref: Reference/PubChem-compound 439218
chemical formula: C27H44N7O20P3S
molecular weight: 911.1575
structure: ChemicalStructure/PW C001063

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

Reference/CAS 2140-48-9
type: UnificationXref
id: 2140-48-9
db: CAS

2.3.1.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001142 Mitochondrial Matrix/Stoichiometry/1.0
right: Acetoacetyl-CoA
right: Coenzyme A
spontaneous: false
EC number: 2.3.1.9
left: Acetyl-CoA
name: 2 Acetyl-CoA ↔ Acetoacetyl-CoA + Coenzyme A
conversion direction: REVERSIBLE

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

4.2.1.17
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000904 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001345 Mitochondrial Matrix/Stoichiometry/1.0
right: Crotonoyl-CoA
right: Water
spontaneous: false
EC number: 4.2.1.17
left: 3-Hydroxybutyryl-CoA
name: 3-Hydroxybutyryl-CoA ↔ Crotonoyl-CoA + Water
conversion direction: REVERSIBLE

Reference/PubChem-compound 439214
type: UnificationXref
id: 439214
db: PubChem-compound

1.3.8.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000856 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/Generic69 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/Generic70 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001345 Mitochondrion/Stoichiometry/1.0
right: Reduced electron-transfer flavoprotein
right: Crotonoyl-CoA
spontaneous: false
EC number: 1.3.8.1
left: electron-transfer flavoprotein
left: Butyryl-CoA
name: Butyryl-CoA + electron-transfer flavoprotein ↔ Crotonoyl-CoA + Reduced electron-transfer flavoprotein
conversion direction: REVERSIBLE

Compound/PW C000904 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Hydroxybutyryl-CoA
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000039
type: UnificationXref
id: HMDB0000039
db: HMDB

Compound/PW C000032 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

Acetoacetyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Acetoacetyl-CoA

Reference/UniProt F1N338
type: UnificationXref
id: F1N338
db: UniProt

Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

SubPathwayInteraction108149
type: Interaction
name: SubPathwayReaction
name: SubPathway108149Reaction
participant: Butyric acid

Acyl-coenzyme A synthetase ACSM1, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Acyl-coenzyme A synthetase ACSM1, mitochondrial

Reference/HMDB HMDB0001484
type: UnificationXref
id: HMDB0001484
db: HMDB

Reference/PubChem-compound 439218
type: UnificationXref
id: 439218
db: PubChem-compound

Hydroxymethylglutaryl-CoA synthase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q2KIE6
organism: Bos taurus

Hydroxymethylglutaryl-CoA synthase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Hydroxymethylglutaryl-CoA synthase, mitochondrial

Hydroxyacyl-CoA dehydrogenase
type: ProteinReference
xref: Reference/UniProt F1N338
organism: Bos taurus

Compound/Generic69 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: electron-transfer flavoprotein
stoichiometric coefficient: 1.0

Acetyl-CoA acetyltransferase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Acetyl-CoA acetyltransferase, mitochondrial

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Butyric acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Butyric acid
name: SubPathwayInput

Butyrate Metabolism
type: Pathway
pathway order: PathwayEnzymeReaction/2112166
pathway order: PathwayEnzymeReaction/2112169
pathway order: PathwaySubPathway/108150
pathway order: PathwayEnzymeReaction/2112167
pathway order: PathwayEnzymeReaction/2112168
pathway order: PathwayTransport/2112174
pathway order: PathwayEnzymeReaction/2112172
pathway order: PathwayEnzymeReaction/2112173
pathway order: PathwayEnzymeReaction/2112170
pathway order: PathwaySubPathway/108149
pathway order: PathwayEnzymeReaction/2112171
pathway component: ReactionCatalysis136036
pathway component: ReactionCatalysis136038
pathway component: ReactionCatalysis136032
pathway component: ReactionCatalysis136034
pathway component: Transport7863
pathway component: ReactionCatalysis136035
pathway component: Intestinal Microflora
pathway component: 6.2.1.2
pathway component: ReactionCatalysis135923
pathway component: 4.1.3.4
pathway component: 2.3.1.9
pathway component: 2.8.3.5
pathway component: 4.2.1.17
pathway component: ReactionCatalysis135928
pathway component: 2.3.3.10
pathway component: ReactionCatalysis135927
pathway component: 1.1.1.35
pathway component: 1.3.8.1
pathway component: Ketone Body Metabolism
xref: Reference/SMPDB SMP0087185
xref: Reference/PathWhiz PW088204
organism: Bos taurus

NAD
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: NAD

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

ChemicalStructure/PW C000042
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)CC(O)=O

Reference/HMDB HMDB0001375
type: UnificationXref
id: HMDB0001375
db: HMDB

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/KEGG Compound C00877
type: UnificationXref
id: C00877
db: KEGG Compound

Compound/PW C000808 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinyl-CoA
stoichiometric coefficient: 1.0

Acetoacetic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Acetoacetic acid
name: SubPathwayInput

Reference/PathWhiz PW000028
type: UnificationXref
id: PW000028
db: PathWhiz

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

3-Hydroxy-3-methylglutaryl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: 3-Hydroxy-3-methylglutaryl-CoA

3-Hydroxybutyryl-CoA
type: SmallMoleculeReference
xref: Reference/CAS 2871-66-1
xref: Reference/KEGG Compound C03561
xref: Reference/PubChem-compound 440045
xref: Reference/HMDB HMDB0001166
xref: Reference/ChEBI CHEBI 15452
xref: Reference/BioCyc 2-METHYL-3-HYDROXY-BUTYRYL-COA
xref: Reference/ChemSpider 389056
chemical formula: C25H42N7O18P3S
molecular weight: 853.152
structure: ChemicalStructure/PW C000904

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

6.2.1.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000856 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000028 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Mitochondrial Matrix/Stoichiometry/1.0
right: Adenosine monophosphate
right: Pyrophosphate
right: Butyryl-CoA
spontaneous: false
EC number: 6.2.1.2
left: Coenzyme A
left: Adenosine triphosphate
left: Butyric acid
name: Adenosine triphosphate + Butyric acid + Coenzyme A → Adenosine monophosphate + Butyryl-CoA + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

4.1.3.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001063 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000042 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/1.0
right: Acetyl-CoA
right: Acetoacetic acid
spontaneous: false
EC number: 4.1.3.4
left: 3-Hydroxy-3-methylglutaryl-CoA
name: 3-Hydroxy-3-methylglutaryl-CoA → Acetoacetic acid + Acetyl-CoA
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

2.8.3.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000808 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000042 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000174 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001142 Mitochondrial Matrix/Stoichiometry/1.0
right: Succinic acid
right: Acetoacetyl-CoA
spontaneous: false
EC number: 2.8.3.5
left: Succinyl-CoA
left: Acetoacetic acid
name: Acetoacetic acid + Succinyl-CoA ↔ Acetoacetyl-CoA + Succinic acid
conversion direction: REVERSIBLE

2.3.3.10
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001063 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001142 Mitochondrial Matrix/Stoichiometry/1.0
right: Coenzyme A
right: 3-Hydroxy-3-methylglutaryl-CoA
spontaneous: false
EC number: 2.3.3.10
left: Acetyl-CoA
left: Water
left: Acetoacetyl-CoA
name: Acetoacetyl-CoA + Acetyl-CoA + Water → 3-Hydroxy-3-methylglutaryl-CoA + Coenzyme A
conversion direction: LEFT_TO_RIGHT

Reference/CAS 110-15-6
type: UnificationXref
id: 110-15-6
db: CAS

Enoyl-CoA hydratase, mitochondrial
type: Complex
component stoichiometry: Protein/15146 Mitochondrial Matrix/Stoichiometry/6.0
cellular location: Mitochondrial Matrix
component: Enoyl-CoA hydratase, mitochondrial

Water
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Water

1.1.1.35
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000904 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001142 Mitochondrial Matrix/Stoichiometry/1.0
right: Acetoacetyl-CoA
right: NADH
right: Hydrogen Ion
spontaneous: false
EC number: 1.1.1.35
left: 3-Hydroxybutyryl-CoA
left: NAD
name: 3-Hydroxybutyryl-CoA + NAD → Acetoacetyl-CoA + Hydrogen Ion + NADH
conversion direction: LEFT_TO_RIGHT

Protein/15413 Mitochondrial Matrix/Stoichiometry/2.0
type: Stoichiometry
physical entity: Hydroxymethylglutaryl-CoA lyase, mitochondrial
stoichiometric coefficient: 2.0

Ketone Body Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108150
pathway component: SubPathwayInteraction108150
xref: Reference/SMPDB SMP0000071
xref: Reference/PathWhiz PW000028
name: SubPathway

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/CAS 1420-36-6
type: UnificationXref
id: 1420-36-6
db: CAS

ChemicalStructure/PW C001063
type: ChemicalStructure
structure format: SMILES

Butyryl-CoA
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Butyryl-CoA

Reference/UniProt Q9XT43
type: UnificationXref
id: Q9XT43
db: UniProt

Reference/HMDB HMDB0001022
type: UnificationXref
id: HMDB0001022
db: HMDB

Short-chain specific acyl-CoA dehydrogenase, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Short-chain specific acyl-CoA dehydrogenase, mitochondrial

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Enoyl-CoA hydratase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q4PS76
organism: Bos taurus

Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Hydroxymethylglutaryl-CoA lyase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Hydroxymethylglutaryl-CoA lyase, mitochondrial

Compound/PW C001345 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Crotonoyl-CoA
stoichiometric coefficient: 1.0

Protein/15401 Mitochondrial Matrix/Stoichiometry/2.0
type: Stoichiometry
physical entity: Hydroxyacyl-CoA dehydrogenase
stoichiometric coefficient: 2.0

Reference/KEGG Compound C00091
type: UnificationXref
id: C00091
db: KEGG Compound

Reference/HMDB HMDB0002009
type: UnificationXref
id: HMDB0002009
db: HMDB

Compound/PW C000042 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetoacetic acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000060
type: UnificationXref
id: HMDB0000060
db: HMDB

Reference/PubChem-compound 96
type: UnificationXref
id: 96
db: PubChem-compound

Reference/ChEBI CHEBI 15344
type: UnificationXref
id: CHEBI:15344
db: ChEBI

Reference/ChEBI CHEBI 15467
type: UnificationXref
id: CHEBI:15467
db: ChEBI

Reference/ChEBI CHEBI 15345
type: UnificationXref
id: CHEBI:15345
db: ChEBI

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

Succinic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Succinic acid

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

Crotonoyl-CoA
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Crotonoyl-CoA

Protein/15146 Mitochondrial Matrix/Stoichiometry/6.0
type: Stoichiometry
physical entity: Enoyl-CoA hydratase, mitochondrial
stoichiometric coefficient: 6.0

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

Reference/UniProt Q3ZBF6
type: UnificationXref
id: Q3ZBF6
db: UniProt

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Compound/PW C001345 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Crotonoyl-CoA
stoichiometric coefficient: 1.0

3-oxoacid CoA-transferase 1
type: Complex
component stoichiometry: Protein/15411 Mitochondrial Matrix/Stoichiometry/2.0
cellular location: Mitochondrial Matrix
component: Succinyl-CoA:3-ketoacid-coenzyme A transferase

Reference/CAS 541-50-4
type: UnificationXref
id: 541-50-4
db: CAS

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Reference/BioCyc 3-METHYLBENZYLSUCCINYL-COA
type: UnificationXref
id: 3-METHYLBENZYLSUCCINYL-COA
db: BioCyc

Reference/HMDB HMDB0001166
type: UnificationXref
id: HMDB0001166
db: HMDB

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Reference/SMPDB SMP0087185
type: UnificationXref
id: SMP0087185
db: SMPDB

ReactionCatalysis136036
type: Catalysis
controller: Hydroxymethylglutaryl-CoA lyase, mitochondrial
controlled: 4.1.3.4
control type: ACTIVATION

Compound/PW C000856 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Butyryl-CoA
stoichiometric coefficient: 1.0

ReactionCatalysis136038
type: Catalysis
controller: Acyl-coenzyme A synthetase ACSM1, mitochondrial
controlled: 6.2.1.2
control type: ACTIVATION

ReactionCatalysis136032
type: Catalysis
controller: Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
controlled: 1.1.1.35
control type: ACTIVATION

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

ReactionCatalysis136034
type: Catalysis
controller: Hydroxymethylglutaryl-CoA synthase, mitochondrial
controlled: 2.3.3.10
control type: ACTIVATION

ReactionCatalysis136035
type: Catalysis
controller: 3-oxoacid CoA-transferase 1
controlled: 2.8.3.5
control type: ACTIVATION

Intestinal Microflora
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108149
pathway component: SubPathwayInteraction108149
name: SubPathway

Hydroxyacyl-CoA dehydrogenase
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Hydroxyacyl-CoA dehydrogenase

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

Reference/ChEBI CHEBI 15473
type: UnificationXref
id: CHEBI:15473
db: ChEBI

Acetyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Acetyl-CoA

Reference/UniProt Q4PS76
type: UnificationXref
id: Q4PS76
db: UniProt

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS