Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Reference/ChEBI CHEBI 16136
type: UnificationXref
id: CHEBI:16136
db: ChEBI

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/UniProt Q5E9R4
type: UnificationXref
id: Q5E9R4
db: UniProt

ChemicalStructure/PW C000448
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CS)C(O)=O

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/PubChem-compound 5975
type: UnificationXref
id: 5975
db: PubChem-compound

Reference/BioCyc CYS
type: UnificationXref
id: CYS
db: BioCyc

tRNA(Cys)
type: Rna
cellular location: Cytoplasm
entity reference: tRNA(Cys)

Reference/ChEBI CHEBI 16134
type: UnificationXref
id: CHEBI:16134
db: ChEBI

γ-Glutamylcysteine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00669
xref: Reference/PubChem-compound 123938
xref: Reference/HMDB HMDB0001049
xref: Reference/ChemSpider 110467
xref: Reference/ChEBI CHEBI 17515
xref: Reference/CAS 636-58-8
xref: Reference/BioCyc L-GAMMA-GLUTAMYLCYSTEINE
chemical formula: C8H14N2O5S
molecular weight: 250.06235
structure: ChemicalStructure/PW C000826

Compound/PW C000035 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonia
stoichiometric coefficient: 1.0

Methionine Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108154
pathway component: SubPathwayInteraction108154
xref: Reference/PathWhiz PW000056
xref: Reference/SMPDB SMP0000033
name: SubPathway

Thiocyanate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001453
xref: Reference/KEGG Compound C01755
xref: Reference/CAS 302-04-5
xref: Reference/ChEBI CHEBI 18022
xref: Reference/ChemSpider 8961
xref: Reference/PubChem-compound 9322
xref: Reference/BioCyc HSCN
chemical formula: CNS
molecular weight: 57.975143
structure: ChemicalStructure/PW C001122

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

Reference/PubChem-compound 18779926
type: UnificationXref
id: 18779926
db: PubChem-compound

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

L-Cysteinyl-tRNA(Cys)
type: Rna
cellular location: Cytoplasm
entity reference: L-Cysteinyl-tRNA(Cys)

Cystathionine gamma-lyase
type: Complex
component stoichiometry: Protein/14804 Cytoplasm/Stoichiometry/4.0
cellular location: Cytoplasm
component: Cystathionine gamma-lyase

Ammonia
type: SmallMoleculeReference
xref: Reference/BioCyc AMMONIA
xref: Reference/CAS 7664-41-7
xref: Reference/HMDB HMDB0000051
xref: Reference/PubChem-compound 222
xref: Reference/KEGG Compound C00014
xref: Reference/ChEBI CHEBI 16134
xref: Reference/ChemSpider 217
chemical formula: H3N
molecular weight: 17.026548
structure: ChemicalStructure/PW C000035

Cystathionine gamma-lyase
type: ProteinReference
xref: Reference/UniProt Q58DW2
organism: Bos taurus

Reference/UniProt Q2T9Y6
type: UnificationXref
id: Q2T9Y6
db: UniProt

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

Reference/ChemSpider 50
type: UnificationXref
id: 50
db: ChemSpider

Reference/TAXONOMY 9913
type: UnificationXref
id: 9913
db: TAXONOMY

Reference/ChEBI CHEBI 17359
type: UnificationXref
id: CHEBI:17359
db: ChEBI

Reference/PathWhiz PW000056
type: UnificationXref
id: PW000056
db: PathWhiz

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

Reference/PathWhiz PW000054
type: UnificationXref
id: PW000054
db: PathWhiz

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/PubChem-compound 439270
type: UnificationXref
id: 439270
db: PubChem-compound

Reference/PubChem-compound 1004
type: UnificationXref
id: 1004
db: PubChem-compound

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Compound/PW C001827 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen sulfide
stoichiometric coefficient: 1.0

CARS protein
type: Protein
cellular location: Cytoplasm
entity reference: CARS protein

Sulfate/Sulfite Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108158
pathway component: SubPathwayInteraction108158
xref: Reference/SMPDB SMP0000041
xref: Reference/PathWhiz PW000040
name: SubPathway

Reference/PubChem-compound 51
type: UnificationXref
id: 51
db: PubChem-compound

Water
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Water

Reference/UniProt Q5E9C5
type: UnificationXref
id: Q5E9C5
db: UniProt

ChemicalStructure/PW C001431
type: ChemicalStructure
structure format: SMILES
structure data: OC(CS)C(O)=O

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Pyruvic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 1060
xref: Reference/HMDB HMDB0000243
xref: Reference/CAS 127-17-3
xref: Reference/BioCyc PYRUVATE
xref: Reference/KEGG Compound C00022
xref: Reference/ChEBI CHEBI 32816
xref: Reference/ChemSpider 1031
chemical formula: C3H4O3
molecular weight: 88.016045
structure: ChemicalStructure/PW C000164

Sulfite
type: SmallMoleculeReference
xref: Reference/CAS 14265-45-3
xref: Reference/BioCyc SO3
xref: Reference/ChEBI CHEBI 17359
xref: Reference/ChemSpider 1068
xref: Reference/KEGG Compound C00094
xref: Reference/HMDB HMDB0000240
xref: Reference/PubChem-compound 1099
chemical formula: H2O3S
molecular weight: 81.972466
structure: ChemicalStructure/PW C000162

Reference/UniProt Q32S38
type: UnificationXref
id: Q32S38
db: UniProt

3-Mercaptolactic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 3-Mercaptolactic acid

Lysosome
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005764

Compound/PW C000095 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000789
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 141158
type: UnificationXref
id: 141158
db: ChemSpider

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/ChEBI CHEBI 17561
type: UnificationXref
id: CHEBI:17561
db: ChEBI

Reference/PathWhiz PW000040
type: UnificationXref
id: PW000040
db: PathWhiz

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/HMDB HMDB0001405
type: UnificationXref
id: HMDB0001405
db: HMDB

Oxoglutaric acid
type: SmallMoleculeReference
xref: Reference/CAS 328-50-7
xref: Reference/PubChem-compound 51
xref: Reference/BioCyc 2-KETOGLUTARATE
xref: Reference/HMDB HMDB0000208
xref: Reference/ChEBI CHEBI 30915
xref: Reference/KEGG Compound C00026
xref: Reference/ChemSpider 50
chemical formula: C5H6O5
molecular weight: 146.02153
structure: ChemicalStructure/PW C000134

Reference/ChemSpider 391
type: UnificationXref
id: 391
db: ChemSpider

ChemicalStructure/PW C001085
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C(=O)CS(O)=O

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

Adenosine monophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine monophosphate

Reference/PathWhiz PW000032
type: UnificationXref
id: PW000032
db: PathWhiz

Reference/PathWhiz PW000038
type: UnificationXref
id: PW000038
db: PathWhiz

Reference/PathWhiz PW000157
type: UnificationXref
id: PW000157
db: PathWhiz

Cysteine dioxygenase type 1
type: ProteinReference
xref: Reference/UniProt Q3SZU4
organism: Bos taurus

ReactionCatalysis168840
type: Catalysis
controller: CARS protein
controlled: 6.1.1.16
control type: ACTIVATION

Reference/PubChem-compound 5862
type: UnificationXref
id: 5862
db: PubChem-compound

Aspartate aminotransferase, cytoplasmic
type: Protein
cellular location: Cytoplasm
entity reference: Aspartate aminotransferase, cytoplasmic

ReactionCatalysis135818
type: Catalysis
controller: Glutamate--cysteine ligase
controlled: 6.3.2.2
control type: ACTIVATION

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Pyruvate Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108159
pathway component: SubPathwayInteraction108159
xref: Reference/SMPDB SMP0000060
xref: Reference/PathWhiz PW000054
name: SubPathway

Reference/CAS 302-04-5
type: UnificationXref
id: 302-04-5
db: CAS

Protein/15049 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glutamate--cysteine ligase regulatory subunit
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0003276
type: UnificationXref
id: HMDB0003276
db: HMDB

CARS protein
type: ProteinReference
xref: Reference/UniProt A4FUC8
organism: Bos taurus

Reaction713
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000162 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001085 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Cytoplasm/Stoichiometry/1.0
right: Pyruvic acid
right: Sulfite
spontaneous: true
left: 3-Sulfinylpyruvic acid
left: Water
name: 3-Sulfinylpyruvic acid + Water → Pyruvic acid + Sulfite
conversion direction: LEFT_TO_RIGHT

Protein/15327 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Aspartate aminotransferase, cytoplasmic
stoichiometric coefficient: 2.0

Reference/HMDB HMDB0000208
type: UnificationXref
id: HMDB0000208
db: HMDB

L-Glutamic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Glutamic acid
name: SubPathwayOutput

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Reference/UniProt Q3SZU4
type: UnificationXref
id: Q3SZU4
db: UniProt

Reference/ChemSpider 217
type: UnificationXref
id: 217
db: ChemSpider

Thiosulfate sulfurtransferase
type: Protein
cellular location: Cytoplasm
entity reference: Thiosulfate sulfurtransferase

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Reference/HMDB HMDB0000574
type: UnificationXref
id: HMDB0000574
db: HMDB

ChemicalStructure/PW C000134
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(=O)C(O)=O

Reference/CAS 7664-38-2
type: UnificationXref
id: 7664-38-2
db: CAS

Reference/ChEBI CHEBI 30915
type: UnificationXref
id: CHEBI:30915
db: ChEBI

Compound/PW C001085 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Sulfinylpyruvic acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 96
type: UnificationXref
id: 96
db: ChemSpider

Reference/GENE ONTOLOGY GO 0005764
type: UnificationXref
id: GO:0005764
db: GENE ONTOLOGY

Reference/BioCyc HSCN
type: UnificationXref
id: HSCN
db: BioCyc

Reference/SMPDB SMP0000041
type: UnificationXref
id: SMP0000041
db: SMPDB

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Transport7868
type: Transport
participant stoichiometry: Compound/PW C000448 Lysosome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000448 Cytosol/Stoichiometry/1.0
right: L-Cysteine
spontaneous: false
left: L-Cysteine
name: L-Cysteine (→) Transport: Bos taurus, Cell, Lysosome to Bos taurus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Reference/ChemSpider 5755
type: UnificationXref
id: 5755
db: ChemSpider

3-Sulfinylpyruvic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 3-Sulfinylpyruvic acid

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

RNA/16 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Cysteinyl-tRNA(Cys)
stoichiometric coefficient: 1.0

Reference/ChemSpider 1031
type: UnificationXref
id: 1031
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/PathWhiz PW088208
type: UnificationXref
id: PW088208
db: PathWhiz

SubPathwayInteraction108152
type: Interaction
name: SubPathwayReaction
name: SubPathway108152Reaction
participant: L-Glutamic acid

3-Mercaptopyruvic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001368
xref: Reference/CAS 2464-23-5
xref: Reference/KEGG Compound C00957
xref: Reference/ChEBI CHEBI 16208
xref: Reference/PubChem-compound 98
xref: Reference/ChemSpider 96
xref: Reference/BioCyc 3-MERCAPTO-PYRUVATE
chemical formula: C3H4O3S
molecular weight: 119.98811
structure: ChemicalStructure/PW C001056

Reference/ChemSpider 16743745
type: UnificationXref
id: 16743745
db: ChemSpider

Reference/BioCyc 3-SULFINYL-PYRUVATE
type: UnificationXref
id: 3-SULFINYL-PYRUVATE
db: BioCyc

SubPathwayInteraction108157
type: Interaction
name: SubPathway108157Reaction
name: SubPathwayReaction
participant: 3-Sulfinoalanine

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

Reference/CAS 7664-41-7
type: UnificationXref
id: 7664-41-7
db: CAS

SubPathwayInteraction108158
type: Interaction
name: SubPathway108158Reaction
name: SubPathwayReaction
participant: 3-Sulfinoalanine

Reference/CAS 7783-06-4
type: UnificationXref
id: 7783-06-4
db: CAS

SubPathwayInteraction108159
type: Interaction
name: SubPathwayReaction
name: SubPathway108159Reaction
participant: Pyruvic acid

Reference/HMDB HMDB0002084
type: UnificationXref
id: HMDB0002084
db: HMDB

γ-Glutamylcysteine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: γ-Glutamylcysteine
name: SubPathwayInput

SubPathwayInteraction108153
type: Interaction
name: SubPathway108153Reaction
name: SubPathwayReaction
participant: γ-Glutamylcysteine

SubPathwayInteraction108154
type: Interaction
name: SubPathway108154Reaction
name: SubPathwayReaction
participant: L-Cysteine

Glycine and Serine Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108156
pathway component: SubPathwayInteraction108156
xref: Reference/PathWhiz PW000157
xref: Reference/SMPDB SMP0000004
name: SubPathway

SubPathwayInteraction108155
type: Interaction
name: SubPathwayReaction
name: SubPathway108155Reaction
participant: L-Cysteine

SubPathwayInteraction108156
type: Interaction
name: SubPathwayReaction
name: SubPathway108156Reaction
participant: L-Cysteine

Oxygen
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Oxygen

6.1.1.16
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000448 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: RNA/15 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: RNA/16 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Cytoplasm/Stoichiometry/1.0
right: Adenosine monophosphate
right: L-Cysteinyl-tRNA(Cys)
right: Pyrophosphate
spontaneous: false
EC number: 6.1.1.16
left: L-Cysteine
left: Adenosine triphosphate
left: tRNA(Cys)
name: Adenosine triphosphate + L-Cysteine + tRNA(Cys) → Adenosine monophosphate + L-Cysteinyl-tRNA(Cys) + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 1068
type: UnificationXref
id: 1068
db: ChemSpider

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H28N7O14P2
molecular weight: 664.11694
structure: ChemicalStructure/PW C000721

Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine triphosphate

Compound/PW C000134 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxoglutaric acid
stoichiometric coefficient: 1.0

Reference/KEGG Compound C05823
type: UnificationXref
id: C05823
db: KEGG Compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Reference/PubChem-compound 222
type: UnificationXref
id: 222
db: PubChem-compound

Reference/KEGG Compound C00014
type: UnificationXref
id: C00014
db: KEGG Compound

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

ChemicalStructure/PW C001441
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

6.3.2.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000826 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000448 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001441 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
right: γ-Glutamylcysteine
right: Adenosine diphosphate
right: Phosphoric acid
spontaneous: false
EC number: 6.3.2.2
left: L-Cysteine
left: Adenosine triphosphate
left: L-Glutamic acid
name: Adenosine triphosphate + L-Cysteine + L-Glutamic acid → Adenosine diphosphate + Phosphoric acid + γ-Glutamylcysteine
conversion direction: LEFT_TO_RIGHT

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: O7P2
molecular weight: 173.91193
structure: ChemicalStructure/PW C000170

Reference/SMPDB SMP0000060
type: UnificationXref
id: SMP0000060
db: SMPDB

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Unknown
type: Protein
cellular location: Cytoplasm
entity reference: Unknown

Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Aspartate aminotransferase, cytoplasmic
type: ProteinReference
xref: Reference/UniProt Q5E9R4
organism: Bos taurus

Pyruvic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pyruvic acid
name: SubPathwayInput

Hydrogen sulfide
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 16136
xref: Reference/BioCyc HS
xref: Reference/KEGG Compound C00283
xref: Reference/PubChem-compound 18779926
xref: Reference/CAS 7783-06-4
xref: Reference/ChemSpider 391
xref: Reference/HMDB HMDB0003276
chemical formula: H2S
molecular weight: 33.98772
structure: ChemicalStructure/PW C001827

Reference/KEGG Compound C00022
type: UnificationXref
id: C00022
db: KEGG Compound

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/PubChem-compound 57517667
type: UnificationXref
id: 57517667
db: PubChem-compound

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/ChemSpider 5653
type: UnificationXref
id: 5653
db: ChemSpider

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

Reference/KEGG Compound C00026
type: UnificationXref
id: C00026
db: KEGG Compound

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

Cysteine dioxygenase type 1
type: Protein
cellular location: Cytoplasm
entity reference: Cysteine dioxygenase type 1

Compound/PW C001122 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thiocyanate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 26078
type: UnificationXref
id: CHEBI:26078
db: ChEBI

Reference/SMPDB SMP0000072
type: UnificationXref
id: SMP0000072
db: SMPDB

Reference/HMDB HMDB0000243
type: UnificationXref
id: HMDB0000243
db: HMDB

Reference/HMDB HMDB0001453
type: UnificationXref
id: HMDB0001453
db: HMDB

Taurine and Hypotaurine Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108157
pathway component: SubPathwayInteraction108157
xref: Reference/PathWhiz PW000038
xref: Reference/SMPDB SMP0000021
name: SubPathway

Thiocyanate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Thiocyanate

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Cyanide
type: SmallMoleculeReference
xref: Reference/ChemSpider 5755
xref: Reference/ChEBI CHEBI 17514
xref: Reference/CAS 57-12-5
xref: Reference/KEGG Compound C00177
xref: Reference/HMDB HMDB0002084
xref: Reference/PubChem-compound 5975
chemical formula: CHN
molecular weight: 27.010899
structure: ChemicalStructure/PW C001399

Compound/PW C001431 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Mercaptolactic acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000240
type: UnificationXref
id: HMDB0000240
db: HMDB

Pantothenate and CoA Biosynthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108155
pathway component: SubPathwayInteraction108155
xref: Reference/PathWhiz PW000032
xref: Reference/SMPDB SMP0000027
name: SubPathway

RNA/15 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: tRNA(Cys)
stoichiometric coefficient: 1.0

Cystathionine gamma-lyase
type: Protein
cellular location: Cytoplasm
entity reference: Cystathionine gamma-lyase

3-Sulfinoalanine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 41721
xref: Reference/HMDB HMDB0000996
xref: Reference/KEGG Compound C00606
xref: Reference/ChemSpider 16743745
xref: Reference/CAS 1115-65-7
xref: Reference/BioCyc 3-SULFINOALANINE
xref: Reference/PubChem-compound 439270
chemical formula: C15H24N2O17P2
molecular weight: 566.055
structure: ChemicalStructure/PW C000789

Reference/KEGG Compound C00957
type: UnificationXref
id: C00957
db: KEGG Compound

Compound/PW C000789 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Sulfinoalanine
stoichiometric coefficient: 1.0

NADH
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NADH

Reference/CAS 52-90-4
type: UnificationXref
id: 52-90-4
db: CAS

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Compound/PW C000164 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1099
type: UnificationXref
id: 1099
db: PubChem-compound

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Reference/CAS 328-50-7
type: UnificationXref
id: 328-50-7
db: CAS

3-Sulfinylpyruvic acid
type: SmallMoleculeReference
xref: Reference/BioCyc 3-SULFINYL-PYRUVATE
xref: Reference/HMDB HMDB0001405
xref: Reference/KEGG Compound C05527
xref: Reference/PubChem-compound 57517667
xref: Reference/ChemSpider 4911362
chemical formula: C3H4O5S
molecular weight: 151.97795
structure: ChemicalStructure/PW C001085

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/CAS 2614-83-7
type: UnificationXref
id: 2614-83-7
db: CAS

Reference/UniProt Q58DW2
type: UnificationXref
id: Q58DW2
db: UniProt

Compound/PW C000826 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: γ-Glutamylcysteine
stoichiometric coefficient: 1.0

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

Reference/KEGG Compound C00283
type: UnificationXref
id: C00283
db: KEGG Compound

Compound/PW C000448 Lysosome/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Cysteine
stoichiometric coefficient: 1.0

Glutamate--cysteine ligase regulatory subunit
type: Protein
cellular location: Cytoplasm
entity reference: Glutamate--cysteine ligase regulatory subunit

Reference/ChemSpider 110467
type: UnificationXref
id: 110467
db: ChemSpider

Reference/SMPDB SMP0000004
type: UnificationXref
id: SMP0000004
db: SMPDB

tRNA(Cys)
type: RnaReference
xref: Reference/ChEBI CHEBI 29167
organism: Bos taurus

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

L-Cysteinyl-tRNA(Cys)
type: RnaReference
xref: Reference/ChEBI CHEBI 29152
organism: Bos taurus

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])(=O)OP([O-])([O-])=O

Compound/PW C000448 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Cysteine
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/KEGG Compound C00606
type: UnificationXref
id: C00606
db: KEGG Compound

Reference/ChEBI CHEBI 17514
type: UnificationXref
id: CHEBI:17514
db: ChEBI

Reference/ChEBI CHEBI 17515
type: UnificationXref
id: CHEBI:17515
db: ChEBI

Sulfite
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Sulfite

Reference/PubChem-compound 160645
type: UnificationXref
id: 160645
db: PubChem-compound

ChemicalStructure/PW C001827
type: ChemicalStructure
structure format: SMILES
structure data: S

Protein/15048 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glutamate-cysteine ligase catalytic subunit
stoichiometric coefficient: 1.0

Cystinosin
type: Protein
entity reference: Cystinosin

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Glutamate-cysteine ligase catalytic subunit
type: Protein
cellular location: Cytoplasm
entity reference: Glutamate-cysteine ligase catalytic subunit

Bos taurus
type: BioSource
xref: Reference/TAXONOMY 9913

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

Reference/CAS 1115-65-7
type: UnificationXref
id: 1115-65-7
db: CAS

ChemicalStructure/PW C001399
type: ChemicalStructure
structure format: SMILES
structure data: C#[N-]

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Compound/PW C001144 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 29167
type: UnificationXref
id: CHEBI:29167
db: ChEBI

Reference/BioCyc SO3
type: UnificationXref
id: SO3
db: BioCyc

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/SMPDB SMP0000027
type: UnificationXref
id: SMP0000027
db: SMPDB

Reference/KEGG Compound C00177
type: UnificationXref
id: C00177
db: KEGG Compound

Reference/ChemSpider 4911362
type: UnificationXref
id: 4911362
db: ChemSpider

3-Sulfinoalanine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 3-Sulfinoalanine
name: SubPathwayInput

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Compound/PW C001441 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoric acid
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000826
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(=O)N[C@@H](CS)C(O)=O)C(O)=O

ChemicalStructure/PW C001122
type: ChemicalStructure
structure format: SMILES
structure data: [S-]C#N

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

Reference/PubChem-compound 123938
type: UnificationXref
id: 123938
db: PubChem-compound

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0001368
type: UnificationXref
id: HMDB0001368
db: HMDB

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Reference/CAS 127-17-3
type: UnificationXref
id: 127-17-3
db: CAS

Reaction145942
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001056 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000448 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134 Cytoplasm/Stoichiometry/1.0
right: 3-Mercaptopyruvic acid
right: L-Glutamic acid
spontaneous: false
left: L-Cysteine
left: Oxoglutaric acid
name: L-Cysteine + Oxoglutaric acid ↔ 3-Mercaptopyruvic acid + L-Glutamic acid
conversion direction: REVERSIBLE

4.4.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001827 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000448 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Cytoplasm/Stoichiometry/1.0
right: Pyruvic acid
right: Ammonia
right: Hydrogen sulfide
spontaneous: false
EC number: 4.4.1.1
left: Water
left: L-Cysteine
name: L-Cysteine + Water → Ammonia + Hydrogen sulfide + Pyruvic acid
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc AMMONIA
type: UnificationXref
id: AMMONIA
db: BioCyc

ChemicalStructure/PW C000035
type: ChemicalStructure
structure format: SMILES
structure data: N

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

L-Cysteine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Cysteine
name: SubPathwayOutput
name: SubPathwayInput

Reference/ChEBI CHEBI 29152
type: UnificationXref
id: CHEBI:29152
db: ChEBI

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine diphosphate

Reference/SMPDB SMP0000021
type: UnificationXref
id: SMP0000021
db: SMPDB

Hydrogen sulfide
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Hydrogen sulfide

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

Cysteine Metabolism
type: Pathway
pathway order: PathwaySubPathway/108154
pathway order: PathwayEnzymeReaction/2112210
pathway order: PathwaySubPathway/108155
pathway order: PathwaySubPathway/108156
pathway order: PathwaySubPathway/108157
pathway order: PathwayEnzymeReaction/2112203
pathway order: PathwayEnzymeReaction/2112211
pathway order: PathwaySubPathway/108152
pathway order: PathwaySubPathway/108153
pathway order: PathwayEnzymeReaction/2112206
pathway order: PathwayEnzymeReaction/2112207
pathway order: PathwayEnzymeReaction/2112204
pathway order: PathwayEnzymeReaction/2112205
pathway order: PathwaySubPathway/108158
pathway order: PathwayTransport/2112212
pathway order: PathwaySubPathway/108159
pathway order: PathwayEnzymeReaction/2112208
pathway order: PathwayEnzymeReaction/2112209
pathway component: TransportCatalysis1005
pathway component: 6.1.1.16
pathway component: ReactionCatalysis136049
pathway component: Reaction713
pathway component: 6.3.2.2
pathway component: Methionine Metabolism
pathway component: Reaction145942
pathway component: 4.4.1.1
pathway component: Glutamate Metabolism
pathway component: Transport7868
pathway component: ReactionCatalysis136055
pathway component: ReactionCatalysis168840
pathway component: 1.13.11.20
pathway component: 1.1.1.27
pathway component: 2.8.1.2
pathway component: Reaction145936
pathway component: ReactionCatalysis135818
pathway component: Taurine and Hypotaurine Metabolism
pathway component: Sulfate/Sulfite Metabolism
pathway component: Pyruvate Metabolism
pathway component: ReactionCatalysis136050
pathway component: ReactionCatalysis136051
pathway component: ReactionCatalysis136052
pathway component: ReactionCatalysis136053
pathway component: Pantothenate and CoA Biosynthesis
pathway component: Glycine and Serine Metabolism
xref: Reference/PathWhiz PW088208
xref: Reference/SMPDB SMP0087189
organism: Bos taurus

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/ChEBI CHEBI 18022
type: UnificationXref
id: CHEBI:18022
db: ChEBI

1.13.11.20
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001065 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000448 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000789 Cytoplasm/Stoichiometry/1.0
right: 3-Sulfinoalanine
spontaneous: false
EC number: 1.13.11.20
left: Oxygen
left: L-Cysteine
name: L-Cysteine + Oxygen → 3-Sulfinoalanine
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 8961
type: UnificationXref
id: 8961
db: ChemSpider

1.1.1.27
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001056 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001431 Cytoplasm/Stoichiometry/1.0
right: 3-Mercaptopyruvic acid
right: NADH
spontaneous: false
EC number: 1.1.1.27
left: 3-Mercaptolactic acid
left: NAD
name: 3-Mercaptolactic acid + NAD → 3-Mercaptopyruvic acid + NADH
conversion direction: LEFT_TO_RIGHT

Phosphoric acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphoric acid

2.8.1.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001122 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001056 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001399 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Cytoplasm/Stoichiometry/1.0
right: Pyruvic acid
right: Thiocyanate
spontaneous: false
EC number: 2.8.1.2
left: 3-Mercaptopyruvic acid
left: Cyanide
name: 3-Mercaptopyruvic acid + Cyanide → Pyruvic acid + Thiocyanate
conversion direction: LEFT_TO_RIGHT

Reaction145936
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000095 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000789 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001085 Cytoplasm/Stoichiometry/1.0
right: 3-Sulfinylpyruvic acid
right: L-Glutamic acid
spontaneous: false
left: Oxoglutaric acid
left: 3-Sulfinoalanine
name: 3-Sulfinoalanine + Oxoglutaric acid → 3-Sulfinylpyruvic acid + L-Glutamic acid
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Pyrophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pyrophosphate

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

ChemicalStructure/PW C000164
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)C(O)=O

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

ChemicalStructure/PW C000162
type: ChemicalStructure
structure format: SMILES
structure data: OS(O)=O

Compound/PW C001065 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Ammonia
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Ammonia

Reference/SMPDB SMP0000033
type: UnificationXref
id: SMP0000033
db: SMPDB

Glutamate--cysteine ligase
type: Complex
component stoichiometry: Protein/15049 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/15048 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Glutamate-cysteine ligase catalytic subunit
component: Glutamate--cysteine ligase regulatory subunit

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

TransportCatalysis1005
type: Catalysis
controller: Cystinosin
controlled: Transport7868
control type: ACTIVATION

ReactionCatalysis136049
type: Catalysis
controller: Aspartate aminotransferase, cytoplasmic
controlled: Reaction145936
control type: ACTIVATION

Reference/BioCyc 2-KETOGLUTARATE
type: UnificationXref
id: 2-KETOGLUTARATE
db: BioCyc

Cystinosin
type: ProteinReference
xref: Reference/UniProt A7MB63

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Reference/BioCyc 3-SULFINOALANINE
type: UnificationXref
id: 3-SULFINOALANINE
db: BioCyc

Reference/KEGG Compound C05527
type: UnificationXref
id: C05527
db: KEGG Compound

Reference/ChemSpider 979
type: UnificationXref
id: 979
db: ChemSpider

Reference/CAS 636-58-8
type: UnificationXref
id: 636-58-8
db: CAS

Thiosulfate sulfurtransferase
type: ProteinReference
xref: Reference/UniProt Q5E9C5
organism: Bos taurus

Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Phosphoric acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/ChEBI CHEBI 26078
xref: Reference/CAS 7664-38-2
xref: Reference/PubChem-compound 1004
xref: Reference/ChemSpider 979
xref: Reference/HMDB HMDB0002142
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001441

Reference/UniProt A7MB63
type: UnificationXref
id: A7MB63
db: UniProt

Glutamate Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108153
pathway order: SubPathwayInteractionSteps/SubPathway108152
pathway component: SubPathwayInteraction108152
pathway component: SubPathwayInteraction108153
xref: Reference/SMPDB SMP0000072
xref: Reference/PathWhiz PW000003
name: SubPathway

Oxoglutaric acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Oxoglutaric acid

Reference/HMDB HMDB0000051
type: UnificationXref
id: HMDB0000051
db: HMDB

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/ChEBI CHEBI 32816
type: UnificationXref
id: CHEBI:32816
db: ChEBI

Reference/BioCyc 3-MERCAPTO-PYRUVATE
type: UnificationXref
id: 3-MERCAPTO-PYRUVATE
db: BioCyc

Compound/PW C000032 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

L-Cysteine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Cysteine

Reference/CAS 2464-23-5
type: UnificationXref
id: 2464-23-5
db: CAS

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/BioCyc PYRUVATE
type: UnificationXref
id: PYRUVATE
db: BioCyc

ReactionCatalysis136055
type: Catalysis
controller: Aspartate aminotransferase, cytoplasmic
controlled: Reaction145942
control type: ACTIVATION

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Compound/PW C000162 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sulfite
stoichiometric coefficient: 1.0

Reference/PubChem-compound 9322
type: UnificationXref
id: 9322
db: PubChem-compound

Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

3-Mercaptopyruvic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 3-Mercaptopyruvic acid

Reference/HMDB HMDB0002127
type: UnificationXref
id: HMDB0002127
db: HMDB

Reference/KEGG Compound C00094
type: UnificationXref
id: C00094
db: KEGG Compound

ReactionCatalysis136050
type: Catalysis
controller: Thiosulfate sulfurtransferase
controlled: 2.8.1.2
control type: ACTIVATION

Reference/PubChem-compound 98
type: UnificationXref
id: 98
db: PubChem-compound

ReactionCatalysis136051
type: Catalysis
controller: Unknown
controlled: 1.1.1.27
control type: ACTIVATION

ReactionCatalysis136052
type: Catalysis
controller: Cysteine dioxygenase type 1
controlled: 1.13.11.20
control type: ACTIVATION

ReactionCatalysis136053
type: Catalysis
controller: Cystathionine gamma-lyase
controlled: 4.4.1.1
control type: ACTIVATION

Protein/14804 Cytoplasm/Stoichiometry/4.0
type: Stoichiometry
physical entity: Cystathionine gamma-lyase
stoichiometric coefficient: 4.0

L-Cysteine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000574
xref: Reference/CAS 52-90-4
xref: Reference/KEGG Compound C00097
xref: Reference/BioCyc CYS
xref: Reference/ChemSpider 5653
xref: Reference/PubChem-compound 5862
xref: Reference/ChEBI CHEBI 17561
chemical formula: C3H7NO2S
molecular weight: 121.01975
structure: ChemicalStructure/PW C000448

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

Compound/PW C000721 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/PathWhiz PW000003
type: UnificationXref
id: PW000003
db: PathWhiz

Compound/PW C001399 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cyanide
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00097
type: UnificationXref
id: C00097
db: KEGG Compound

Reference/BioCyc HS
type: UnificationXref
id: HS
db: BioCyc

Reference/HMDB HMDB0001049
type: UnificationXref
id: HMDB0001049
db: HMDB

Reference/HMDB HMDB0000996
type: UnificationXref
id: HMDB0000996
db: HMDB

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/CAS 57-12-5
type: UnificationXref
id: 57-12-5
db: CAS

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Reference/PubChem-compound 1060
type: UnificationXref
id: 1060
db: PubChem-compound

Reference/KEGG Compound C00669
type: UnificationXref
id: C00669
db: KEGG Compound

Reference/CAS 14265-45-3
type: UnificationXref
id: 14265-45-3
db: CAS

Reference/ChEBI CHEBI 41721
type: UnificationXref
id: CHEBI:41721
db: ChEBI

Reference/KEGG Compound C01755
type: UnificationXref
id: C01755
db: KEGG Compound

Glutamate--cysteine ligase regulatory subunit
type: ProteinReference
xref: Reference/UniProt Q2T9Y6
organism: Bos taurus

Reference/SMPDB SMP0087189
type: UnificationXref
id: SMP0087189
db: SMPDB

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Glutamate-cysteine ligase catalytic subunit
type: ProteinReference
xref: Reference/UniProt Q32S38
organism: Bos taurus

Reference/ChEBI CHEBI 16208
type: UnificationXref
id: CHEBI:16208
db: ChEBI

Aspartate aminotransferase, cytoplasmic
type: Complex
component stoichiometry: Protein/15327 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Aspartate aminotransferase, cytoplasmic

Unknown
type: ProteinReference
organism: Bos taurus

Reference/BioCyc L-GAMMA-GLUTAMYLCYSTEINE
type: UnificationXref
id: L-GAMMA-GLUTAMYLCYSTEINE
db: BioCyc

ChemicalStructure/PW C001056
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C(=O)CS

Compound/PW C001056 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Mercaptopyruvic acid
stoichiometric coefficient: 1.0

Cyanide
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Cyanide

3-Mercaptolactic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0002127
xref: Reference/CAS 2614-83-7
xref: Reference/ChemSpider 141158
xref: Reference/PubChem-compound 160645
xref: Reference/KEGG Compound C05823
chemical formula: C3H6O3S
molecular weight: 122.00376
structure: ChemicalStructure/PW C001431

Reference/UniProt A4FUC8
type: UnificationXref
id: A4FUC8
db: UniProt

Compound/PW C000448 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Cysteine
stoichiometric coefficient: 1.0

NAD
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NAD

L-Cysteine
type: SmallMolecule
cellular location: Lysosome
entity reference: L-Cysteine

Reference/HMDB HMDB0002142
type: UnificationXref
id: HMDB0002142
db: HMDB