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D-Arginine and D-Ornithine Metabolism
Last Updated: 2019-08-30
D-Amino acids have been show to be present in high concentrations in humans and play a role in biological functions. D-Amino may have negative effects as they can be found in some bacteria or form spontaneously in certain reactions. D-Amino acid oxidase (DAAO) is one of the main enzymes that metabolize D-Amino acids via deamination. DAAO is highly specific towards D-amino acids and favours free neutral D-amino acids or those with hydrophobic, polar or aromatic groups. Acidic amino acids are not catalyze by DAOO.
D-Arginine and D-Ornithine Metabolism References
Simonic T, Duga S, Negri A, Tedeschi G, Malcovati M, Tenchini ML, Ronchi S: cDNA cloning and expression of the flavoprotein D-aspartate oxidase from bovine kidney cortex. Biochem J. 1997 Mar 15;322 ( Pt 3):729-35. doi: 10.1042/bj3220729.Pubmed: 9148742
Negri A, Ceciliani F, Tedeschi G, Simonic T, Ronchi S: The primary structure of the flavoprotein D-aspartate oxidase from beef kidney. J Biol Chem. 1992 Jun 15;267(17):11865-71.Pubmed: 1601857
This pathway was propagated using PathWhiz - Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0000036
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