Reference/ChemSpider 4516
type: UnificationXref
id: 4516
db: ChemSpider

Reference/CAS 7196-09-0
type: UnificationXref
id: 7196-09-0
db: CAS

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Dephospho-CoA kinase domain-containing protein
type: Protein
cellular location: Cytoplasm
entity reference: Dephospho-CoA kinase domain-containing protein

ChemicalStructure/PW C000448
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CS)C(O)=O

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/BioCyc CYS
type: UnificationXref
id: CYS
db: BioCyc

Reference/ChemSpider 389202
type: UnificationXref
id: 389202
db: ChemSpider

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Cysteamine
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Cysteamine

Reference/HMDB HMDB0000095
type: UnificationXref
id: HMDB0000095
db: HMDB

Reference/UniProt F1MFB8
type: UnificationXref
id: F1MFB8
db: UniProt

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

Reference/TAXONOMY 9913
type: UnificationXref
id: 9913
db: TAXONOMY

Reference/PubChem-compound 479
type: UnificationXref
id: 479
db: PubChem-compound

Reference/PubChem-compound 6131
type: UnificationXref
id: 6131
db: PubChem-compound

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

Reference/ChemSpider 5834
type: UnificationXref
id: 5834
db: ChemSpider

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/ChemSpider 128
type: UnificationXref
id: 128
db: ChemSpider

Compound/PW C001061 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dephospho-CoA
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Water
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Water

Pantetheinase
type: Protein
cellular location: Cell Membrane
entity reference: Pantetheinase

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

SubPathwayInteraction108198
type: Interaction
name: SubPathwayReaction
name: SubPathway108198Reaction
participant: L-Cysteine

SubPathwayInteraction108199
type: Interaction
name: SubPathway108199Reaction
name: SubPathwayReaction
participant: D-Pantothenoyl-L-cysteine
participant: Pantothenol

Reference/BioCyc PANTETHEINE-P
type: UnificationXref
id: PANTETHEINE-P
db: BioCyc

Reference/ChEBI CHEBI 18416
type: UnificationXref
id: CHEBI:18416
db: ChEBI

Reference/BioCyc DEPHOSPHO-COA
type: UnificationXref
id: DEPHOSPHO-COA
db: BioCyc

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/BioCyc R-4-PHOSPHOPANTOTHENOYL-L-CYSTEINE
type: UnificationXref
id: R-4-PHOSPHOPANTOTHENOYL-L-CYSTEINE
db: BioCyc

Reference/ChEBI CHEBI 17561
type: UnificationXref
id: CHEBI:17561
db: ChEBI

D-4'-Phosphopantothenate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C03492
xref: Reference/HMDB HMDB0001016
xref: Reference/BioCyc 4-P-PANTOTHENATE
xref: Reference/ChEBI CHEBI 15905
xref: Reference/PubChem-compound 131
xref: Reference/ChemSpider 128
chemical formula: C9H18NO8P
molecular weight: 299.077
structure: ChemicalStructure/PW C000804

Compound/PW C001099 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Carbon dioxide
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Carbon dioxide

D-Pantothenoyl-L-cysteine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: D-Pantothenoyl-L-cysteine
name: SubPathwayOutput

Compound/PW C000064 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cytidine monophosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Reference/HMDB HMDB0004231
type: UnificationXref
id: HMDB0004231
db: HMDB

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

Adenosine monophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine monophosphate

Reference/KEGG Compound C01678
type: UnificationXref
id: C01678
db: KEGG Compound

Pantothenic acid
type: SmallMoleculeReference
xref: Reference/ChemSpider 963
xref: Reference/HMDB HMDB0000210
xref: Reference/KEGG Compound C00864
xref: Reference/BioCyc PANTOTHENATE
xref: Reference/PubChem-compound 988
xref: Reference/CAS 79-83-4
xref: Reference/ChEBI CHEBI 7916
chemical formula: C9H17NO5
molecular weight: 219.11067
structure: ChemicalStructure/PW C000136

ChemicalStructure/PW C001887
type: ChemicalStructure
structure format: SMILES
structure data: CC(C)(CO)C(O)C(=O)NCCC(=O)NCCS

Reference/PubChem-compound 5862
type: UnificationXref
id: 5862
db: PubChem-compound

Reference/PubChem-compound 131
type: UnificationXref
id: 131
db: PubChem-compound

Reference/ChemSpider 388463
type: UnificationXref
id: 388463
db: ChemSpider

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0001416
type: UnificationXref
id: HMDB0001416
db: HMDB

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Reference/CAS 63-37-6
type: UnificationXref
id: 63-37-6
db: CAS

ChemicalStructure/PW C001093
type: ChemicalStructure
structure format: SMILES
structure data: CC(C)(COP(O)(O)=O)C(O)C(=O)NCCC(=O)NCCS

Phosphopantothenate--cysteine ligase
type: Complex
component stoichiometry: Protein/15770 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: PPCS protein

Reference/BioCyc PANTOTHENATE
type: UnificationXref
id: PANTOTHENATE
db: BioCyc

Phosphopantothenoylcysteine decarboxylase
type: ProteinReference
xref: Reference/UniProt Q58DB8
organism: Bos taurus

Reference/ChEBI CHEBI 17141
type: UnificationXref
id: CHEBI:17141
db: ChEBI

PPCS protein
type: ProteinReference
xref: Reference/UniProt F1MFB8
organism: Bos taurus

ChemicalStructure/PW C000804
type: ChemicalStructure
structure format: SMILES
structure data: CC(C)(COP(O)(O)=O)C(O)C(O)=NCCC(O)=O

Intestinal Microflora
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108199
pathway component: SubPathwayInteraction108199
name: SubPathway

Reference/PathWhiz PW088226
type: UnificationXref
id: PW088226
db: PathWhiz

Reference/HMDB HMDB0000574
type: UnificationXref
id: HMDB0000574
db: HMDB

Reference/HMDB HMDB0000210
type: UnificationXref
id: HMDB0000210
db: HMDB

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

Reference/BioCyc 4-P-PANTOTHENATE
type: UnificationXref
id: 4-P-PANTOTHENATE
db: BioCyc

Pantetheine 4'-phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pantetheine 4'-phosphate

ChemicalStructure/PW C000136
type: ChemicalStructure
structure format: SMILES
structure data: CC(C)(CO)[C@@H](O)C(=O)NCCC(O)=O

Reaction146059
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001061 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001093 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Cytoplasm/Stoichiometry/1.0
right: Adenosine monophosphate
right: Pantetheine 4'-phosphate
spontaneous: false
left: Dephospho-CoA
left: Water
name: Dephospho-CoA + Water ↔ Adenosine monophosphate + Pantetheine 4'-phosphate
conversion direction: REVERSIBLE

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

4'-Phosphopantothenoylcysteine
type: SmallMoleculeReference
xref: Reference/CAS 7196-09-0
xref: Reference/KEGG Compound C04352
xref: Reference/HMDB HMDB0001117
xref: Reference/ChEBI CHEBI 15769
xref: Reference/BioCyc R-4-PHOSPHOPANTOTHENOYL-L-CYSTEINE
xref: Reference/PubChem-compound 440304
xref: Reference/ChemSpider 389278
chemical formula: C12H23N2O9PS
molecular weight: 402.08618
structure: ChemicalStructure/PW C000872

Reaction146058
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001061 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
right: Coenzyme A
right: Adenosine diphosphate
spontaneous: false
left: Dephospho-CoA
left: Adenosine triphosphate
name: Adenosine triphosphate + Dephospho-CoA → Adenosine diphosphate + Coenzyme A
conversion direction: LEFT_TO_RIGHT

Compound/PW C001750 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cysteamine
stoichiometric coefficient: 1.0

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Reaction146056
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001061 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001093 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
right: Dephospho-CoA
right: Pyrophosphate
spontaneous: false
left: Pantetheine 4'-phosphate
left: Adenosine triphosphate
name: Adenosine triphosphate + Pantetheine 4'-phosphate → Dephospho-CoA + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Pantothenate and CoA Biosynthesis
type: Pathway
pathway order: PathwayEnzymeReaction/2112341
pathway order: PathwaySubPathway/108198
pathway order: PathwayEnzymeReaction/2112342
pathway order: PathwaySubPathway/108199
pathway order: PathwayEnzymeReaction/2112345
pathway order: PathwayEnzymeReaction/2112346
pathway order: PathwayEnzymeReaction/2112343
pathway order: PathwayEnzymeReaction/2112344
pathway order: PathwayEnzymeReaction/2112349
pathway order: PathwayEnzymeReaction/2112347
pathway order: PathwayEnzymeReaction/2112348
pathway component: ReactionCatalysis136175
pathway component: ReactionCatalysis136176
pathway component: ReactionCatalysis136178
pathway component: Intestinal Microflora
pathway component: 6.3.2.5
pathway component: 2.7.1.33
pathway component: Reaction146059
pathway component: Reaction146058
pathway component: ReactionCatalysis136182
pathway component: 3.5.1.92
pathway component: ReactionCatalysis136172
pathway component: ReactionCatalysis136183
pathway component: Reaction146056
pathway component: ReactionCatalysis136174
pathway component: 4.1.1.36
pathway component: ReactionCatalysis136180
pathway component: ReactionCatalysis136170
pathway component: Cysteine Metabolism
xref: Reference/SMPDB SMP0087207
xref: Reference/PathWhiz PW088226
organism: Bos taurus

Reference/HMDB HMDB0002991
type: UnificationXref
id: HMDB0002991
db: HMDB

2.7.1.33
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002959 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000872 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
right: 4'-Phosphopantothenoylcysteine
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.1.33
left: D-Pantothenoyl-L-cysteine
left: Adenosine triphosphate
name: Adenosine triphosphate + D-Pantothenoyl-L-cysteine → 4'-Phosphopantothenoylcysteine + Adenosine diphosphate
conversion direction: LEFT_TO_RIGHT

4.1.1.36
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001093 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000872 Cytoplasm/Stoichiometry/1.0
right: Pantetheine 4'-phosphate
right: Carbon dioxide
spontaneous: false
EC number: 4.1.1.36
left: 4'-Phosphopantothenoylcysteine
name: 4'-Phosphopantothenoylcysteine → Carbon dioxide + Pantetheine 4'-phosphate
conversion direction: LEFT_TO_RIGHT

2.7.1.33
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001887 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001093 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
right: Pantetheine 4'-phosphate
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.1.33
left: Adenosine triphosphate
left: Pantetheine
name: Adenosine triphosphate + Pantetheine → Adenosine diphosphate + Pantetheine 4'-phosphate
conversion direction: LEFT_TO_RIGHT

Dephospho-CoA kinase domain-containing protein
type: ProteinReference
xref: Reference/UniProt Q3ZBS0
organism: Bos taurus

Pantothenate kinase 1
type: Complex
component stoichiometry: Protein/15764 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Pantothenate kinase 3

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
type: ProteinReference
xref: Reference/UniProt Q0II99
organism: Bos taurus

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/BioCyc CTP
type: UnificationXref
id: CTP
db: BioCyc

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Pantothenic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pantothenic acid

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

6.3.2.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000064 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000448 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000804 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000872 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000057 Cytoplasm/Stoichiometry/1.0
right: Cytidine monophosphate
right: 4'-Phosphopantothenoylcysteine
right: Pyrophosphate
spontaneous: false
EC number: 6.3.2.5
left: L-Cysteine
left: Cytidine triphosphate
left: D-4'-Phosphopantothenate
name: Cytidine triphosphate + D-4'-Phosphopantothenate + L-Cysteine → 4'-Phosphopantothenoylcysteine + Cytidine monophosphate + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

2.7.1.33
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000136 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000804 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
right: Adenosine diphosphate
right: D-4'-Phosphopantothenate
spontaneous: false
EC number: 2.7.1.33
left: Adenosine triphosphate
left: Pantothenic acid
name: Adenosine triphosphate + Pantothenic acid → Adenosine diphosphate + D-4'-Phosphopantothenate
conversion direction: LEFT_TO_RIGHT

3.5.1.92
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001887 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000136 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001750 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
right: Cysteamine
right: Pantothenic acid
spontaneous: false
EC number: 3.5.1.92
left: Pantetheine
left: Water
name: Pantetheine + Water → Cysteamine + Pantothenic acid
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 15769
type: UnificationXref
id: CHEBI:15769
db: ChEBI

Reference/ChEBI CHEBI 16858
type: UnificationXref
id: CHEBI:16858
db: ChEBI

Pantetheine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pantetheine

Reference/SMPDB SMP0087207
type: UnificationXref
id: SMP0087207
db: SMPDB

Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine triphosphate

Reference/ChEBI CHEBI 17361
type: UnificationXref
id: CHEBI:17361
db: ChEBI

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Phosphopantothenoylcysteine decarboxylase
type: Protein
cellular location: Cytoplasm
entity reference: Phosphopantothenoylcysteine decarboxylase

Reference/KEGG Compound C05944
type: UnificationXref
id: C05944
db: KEGG Compound

Pantothenol
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pantothenol
name: SubPathwayInput

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: O7P2
molecular weight: 173.91193
structure: ChemicalStructure/PW C000170

Reference/CAS 496-65-1
type: UnificationXref
id: 496-65-1
db: CAS

Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Cytidine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17677
xref: Reference/CAS 65-47-4
xref: Reference/PubChem-compound 6176
xref: Reference/KEGG Compound C00063
xref: Reference/ChemSpider 5941
xref: Reference/HMDB HMDB0000082
xref: Reference/BioCyc CTP
chemical formula: C9H16N3O14P3
molecular weight: 482.9845
structure: ChemicalStructure/PW C000057

ChemicalStructure/PW C002097
type: ChemicalStructure
structure format: SMILES
structure data: CC(C)(CO)C(O)C(=O)NCCCO

Cysteine Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108198
pathway component: SubPathwayInteraction108198
xref: Reference/SMPDB SMP0000013
xref: Reference/PathWhiz PW000018
name: SubPathway

Pantetheine
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Pantetheine

Protein/15764 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Pantothenate kinase 3
stoichiometric coefficient: 2.0

Reference/BioCyc CPD-3721
type: UnificationXref
id: CPD-3721
db: BioCyc

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/ChemSpider 5653
type: UnificationXref
id: 5653
db: ChemSpider

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

Reference/ChemSpider 466
type: UnificationXref
id: 466
db: ChemSpider

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Protein/15774 Cytoplasm/Stoichiometry/3.0
type: Stoichiometry
physical entity: Phosphopantothenoylcysteine decarboxylase
stoichiometric coefficient: 3.0

Coenzyme A
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Coenzyme A

Reference/UniProt A6QPH4
type: UnificationXref
id: A6QPH4
db: UniProt

Cytidine monophosphate
type: SmallMoleculeReference
xref: Reference/BioCyc CMP
xref: Reference/ChemSpider 5901
xref: Reference/PubChem-compound 6131
xref: Reference/ChEBI CHEBI 17361
xref: Reference/KEGG Compound C00055
xref: Reference/HMDB HMDB0000095
xref: Reference/CAS 63-37-6
chemical formula: C9H14N3O8P
molecular weight: 323.05185
structure: ChemicalStructure/PW C000064

Reference/KEGG Compound C00831
type: UnificationXref
id: C00831
db: KEGG Compound

Reference/CAS 79-83-4
type: UnificationXref
id: 79-83-4
db: CAS

Reference/CAS 52-90-4
type: UnificationXref
id: 52-90-4
db: CAS

Reference/CAS 3633-59-8
type: UnificationXref
id: 3633-59-8
db: CAS

Reference/PubChem-compound 440304
type: UnificationXref
id: 440304
db: PubChem-compound

Reference/KEGG Compound C04079
type: UnificationXref
id: C04079
db: KEGG Compound

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

ChemicalStructure/PW C000057
type: ChemicalStructure
structure format: SMILES

Compound/PW C001316 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Pantothenate kinase 3
type: Protein
cellular location: Cytoplasm
entity reference: Pantothenate kinase 3

Compound/PW C000872 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4'-Phosphopantothenoylcysteine
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])(=O)OP([O-])([O-])=O

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Reference/KEGG Compound C01134
type: UnificationXref
id: C01134
db: KEGG Compound

Pantetheine
type: SmallMoleculeReference
xref: Reference/BioCyc PANTETHEINE-P
xref: Reference/PubChem-compound 479
xref: Reference/ChemSpider 466
xref: Reference/CAS 496-65-1
xref: Reference/KEGG Compound C00831
xref: Reference/ChEBI CHEBI 16753
xref: Reference/HMDB HMDB0003426
chemical formula: C11H22N2O4S
molecular weight: 278.13004
structure: ChemicalStructure/PW C001887

Water
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Water

Reference/UniProt Q08DA5
type: UnificationXref
id: Q08DA5
db: UniProt

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000064
type: ChemicalStructure
structure format: SMILES

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
type: Complex
component stoichiometry: Protein/15784 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Bos taurus
type: BioSource
xref: Reference/TAXONOMY 9913

Reference/HMDB HMDB0001117
type: UnificationXref
id: HMDB0001117
db: HMDB

Compound/PW C000136 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pantothenic acid
stoichiometric coefficient: 1.0

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Compound/PW C001093 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pantetheine 4'-phosphate
stoichiometric coefficient: 1.0

Reference/SMPDB SMP0000013
type: UnificationXref
id: SMP0000013
db: SMPDB

Pantetheine 4'-phosphate
type: SmallMoleculeReference
xref: Reference/BioCyc PANTETHEINE-P
xref: Reference/ChemSpider 962
xref: Reference/HMDB HMDB0001416
xref: Reference/PubChem-compound 987
xref: Reference/KEGG Compound C01134
xref: Reference/ChEBI CHEBI 16858
xref: Reference/CAS 2226-71-3
chemical formula: C11H23N2O7PS
molecular weight: 358.09634
structure: ChemicalStructure/PW C001093

Reference/ChEBI CHEBI 7916
type: UnificationXref
id: CHEBI:7916
db: ChEBI

Reference/ChemSpider 5901
type: UnificationXref
id: 5901
db: ChemSpider

Reference/ChEBI CHEBI 16753
type: UnificationXref
id: CHEBI:16753
db: ChEBI

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

Reference/KEGG Compound C00055
type: UnificationXref
id: C00055
db: KEGG Compound

PPCS protein
type: Protein
cellular location: Cytoplasm
entity reference: PPCS protein

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/UniProt Q3ZBS0
type: UnificationXref
id: Q3ZBS0
db: UniProt

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

Dephospho-CoA
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Dephospho-CoA

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 439335
type: UnificationXref
id: 439335
db: PubChem-compound

Reference/KEGG Compound C00063
type: UnificationXref
id: C00063
db: KEGG Compound

Reference/HMDB HMDB0003426
type: UnificationXref
id: HMDB0003426
db: HMDB

L-Cysteine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Cysteine
name: SubPathwayOutput

ReactionCatalysis136182
type: Catalysis
controller: Dephospho-CoA kinase domain-containing protein
controlled: Reaction146058
control type: ACTIVATION

ReactionCatalysis136183
type: Catalysis
controller: Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
controlled: Reaction146059
control type: ACTIVATION

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine diphosphate

ReactionCatalysis136180
type: Catalysis
controller: Dephospho-CoA kinase domain-containing protein
controlled: Reaction146056
control type: ACTIVATION

Dephospho-CoA
type: SmallMoleculeReference
xref: Reference/PubChem-compound 439335
xref: Reference/ChEBI CHEBI 15468
xref: Reference/BioCyc DEPHOSPHO-COA
xref: Reference/HMDB HMDB0001373
xref: Reference/CAS 3633-59-8
xref: Reference/KEGG Compound C00882
xref: Reference/ChemSpider 388463
chemical formula: C21H35N7O13P2S
molecular weight: 687.14886
structure: ChemicalStructure/PW C001061

Reference/KEGG Compound C00864
type: UnificationXref
id: C00864
db: KEGG Compound

Pantothenate kinase 3
type: ProteinReference
xref: Reference/UniProt Q08DA5
organism: Bos taurus

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/ChEBI CHEBI 895821
type: UnificationXref
id: CHEBI:895821
db: ChEBI

Pantetheinase
type: ProteinReference
xref: Reference/UniProt A6QPH4
organism: Bos taurus

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Compound/PW C000136 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pantothenic acid
stoichiometric coefficient: 1.0

Reference/CAS 2226-71-3
type: UnificationXref
id: 2226-71-3
db: CAS

Reference/ChemSpider 389278
type: UnificationXref
id: 389278
db: ChemSpider

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Pyrophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pyrophosphate

D-Pantothenoyl-L-cysteine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0006834
xref: Reference/ChEBI CHEBI 18416
xref: Reference/PubChem-compound 440217
xref: Reference/ChemSpider 389202
xref: Reference/KEGG Compound C04079
chemical formula: C12H22N2O6S
molecular weight: 322.11984
structure: ChemicalStructure/PW C002959

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

Reference/HMDB HMDB0001016
type: UnificationXref
id: HMDB0001016
db: HMDB

Reference/CAS 65-47-4
type: UnificationXref
id: 65-47-4
db: CAS

Cysteamine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C01678
xref: Reference/ChemSpider 5834
xref: Reference/BioCyc CPD-3721
xref: Reference/ChEBI CHEBI 17141
xref: Reference/CAS 60-23-1
xref: Reference/HMDB HMDB0002991
xref: Reference/PubChem-compound 6058
chemical formula: C2H7NS
molecular weight: 77.02992
structure: ChemicalStructure/PW C001750

Reference/CAS 16485-10-2
type: UnificationXref
id: 16485-10-2
db: CAS

Reference/HMDB HMDB0001373
type: UnificationXref
id: HMDB0001373
db: HMDB

Protein/15784 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
stoichiometric coefficient: 2.0

Phosphopantothenoylcysteine decarboxylase
type: Complex
component stoichiometry: Protein/15774 Cytoplasm/Stoichiometry/3.0
cellular location: Cytoplasm
component: Phosphopantothenoylcysteine decarboxylase

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

4'-Phosphopantothenoylcysteine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 4'-Phosphopantothenoylcysteine

Cytidine triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Cytidine triphosphate

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

D-4'-Phosphopantothenate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: D-4'-Phosphopantothenate

Compound/PW C001887 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pantetheine
stoichiometric coefficient: 1.0

Reference/BioCyc CMP
type: UnificationXref
id: CMP
db: BioCyc

Pantothenol
type: SmallMoleculeReference
xref: Reference/ChemSpider 4516
xref: Reference/ChEBI CHEBI 895821
xref: Reference/HMDB HMDB0004231
xref: Reference/CAS 16485-10-2
xref: Reference/KEGG Compound C05944
xref: Reference/PubChem-compound 4678
xref: Reference/BioCyc PANTOTHENOL
chemical formula: C9H19NO4
molecular weight: 205.13141
structure: ChemicalStructure/PW C002097

Reference/HMDB HMDB0006834
type: UnificationXref
id: HMDB0006834
db: HMDB

Reference/PathWhiz PW000018
type: UnificationXref
id: PW000018
db: PathWhiz

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/UniProt Q58DB8
type: UnificationXref
id: Q58DB8
db: UniProt

ChemicalStructure/PW C001061
type: ChemicalStructure
structure format: SMILES

Compound/PW C000032 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 17677
type: UnificationXref
id: CHEBI:17677
db: ChEBI

Reference/PubChem-compound 6176
type: UnificationXref
id: 6176
db: PubChem-compound

ReactionCatalysis136175
type: Catalysis
controller: Pantothenate kinase 1
controlled: 2.7.1.33
control type: ACTIVATION

ReactionCatalysis136176
type: Catalysis
controller: Phosphopantothenoylcysteine decarboxylase
controlled: 4.1.1.36
control type: ACTIVATION

ReactionCatalysis136178
type: Catalysis
controller: Pantothenate kinase 1
controlled: 2.7.1.33
control type: ACTIVATION

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C002959
type: ChemicalStructure
structure format: SMILES

Compound/PW C000057 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cytidine triphosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 4678
type: UnificationXref
id: 4678
db: PubChem-compound

Reference/PubChem-compound 440217
type: UnificationXref
id: 440217
db: PubChem-compound

Reference/BioCyc PANTOTHENOL
type: UnificationXref
id: PANTOTHENOL
db: BioCyc

Reference/PubChem-compound 6058
type: UnificationXref
id: 6058
db: PubChem-compound

Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00882
type: UnificationXref
id: C00882
db: KEGG Compound

Reference/ChemSpider 963
type: UnificationXref
id: 963
db: ChemSpider

Reference/ChemSpider 962
type: UnificationXref
id: 962
db: ChemSpider

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

ChemicalStructure/PW C001750
type: ChemicalStructure
structure format: SMILES
structure data: NCCS

Pantothenic acid
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Pantothenic acid

ReactionCatalysis136172
type: Catalysis
controller: Pantothenate kinase 1
controlled: 2.7.1.33
control type: ACTIVATION

ReactionCatalysis136174
type: Catalysis
controller: Phosphopantothenate--cysteine ligase
controlled: 6.3.2.5
control type: ACTIVATION

ReactionCatalysis136170
type: Catalysis
controller: Pantetheinase
controlled: 3.5.1.92
control type: ACTIVATION

L-Cysteine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000574
xref: Reference/CAS 52-90-4
xref: Reference/KEGG Compound C00097
xref: Reference/BioCyc CYS
xref: Reference/ChemSpider 5653
xref: Reference/PubChem-compound 5862
xref: Reference/ChEBI CHEBI 17561
chemical formula: C3H7NO2S
molecular weight: 121.01975
structure: ChemicalStructure/PW C000448

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Reference/PubChem-compound 988
type: UnificationXref
id: 988
db: PubChem-compound

Reference/UniProt Q0II99
type: UnificationXref
id: Q0II99
db: UniProt

Reference/ChemSpider 5941
type: UnificationXref
id: 5941
db: ChemSpider

Reference/ChEBI CHEBI 15468
type: UnificationXref
id: CHEBI:15468
db: ChEBI

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

Reference/PubChem-compound 987
type: UnificationXref
id: 987
db: PubChem-compound

Compound/PW C000804 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-4'-Phosphopantothenate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00097
type: UnificationXref
id: C00097
db: KEGG Compound

Reference/KEGG Compound C03492
type: UnificationXref
id: C03492
db: KEGG Compound

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

ChemicalStructure/PW C000872
type: ChemicalStructure
structure format: SMILES

Reference/CAS 60-23-1
type: UnificationXref
id: 60-23-1
db: CAS

Cytidine monophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Cytidine monophosphate

Compound/PW C001887 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pantetheine
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Protein/15770 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: PPCS protein
stoichiometric coefficient: 2.0

Reference/KEGG Compound C04352
type: UnificationXref
id: C04352
db: KEGG Compound

Compound/PW C002959 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Pantothenoyl-L-cysteine
stoichiometric coefficient: 1.0

Compound/PW C000448 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Cysteine
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000082
type: UnificationXref
id: HMDB0000082
db: HMDB

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
type: Protein
cellular location: Cytoplasm
entity reference: Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Reference/ChEBI CHEBI 15905
type: UnificationXref
id: CHEBI:15905
db: ChEBI