Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Tyrosinase
type: Protein
cellular location: Melanosome Membrane
entity reference: Tyrosinase

Reference/ChemSpider 431981
type: UnificationXref
id: 431981
db: ChemSpider

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

Reference/HMDB HMDB0003364
type: UnificationXref
id: HMDB0003364
db: HMDB

Reference/TAXONOMY 9913
type: UnificationXref
id: 9913
db: TAXONOMY

Compound/PW C001957 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dimethylbenzimidazole
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

Reference/UniProt Q3SZP4
type: UnificationXref
id: Q3SZP4
db: UniProt

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Intestinal Microflora
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108203
pathway component: SubPathwayInteraction108203
name: SubPathway

Melanosome Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0033162

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Intestinal Microflora
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108204
pathway component: SubPathwayInteraction108204
name: SubPathway

Intestinal Microflora
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108202
pathway component: SubPathwayInteraction108202
name: SubPathway

Reference/ChEBI CHEBI 17594
type: UnificationXref
id: CHEBI:17594
db: ChEBI

Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reaction2332
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001957 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000165 Cytoplasm/Stoichiometry/1.0
right: Dimethylbenzimidazole
spontaneous: false
left: Riboflavin
name: Riboflavin → Dimethylbenzimidazole
conversion direction: LEFT_TO_RIGHT

Compound/PW C001860 Melanosome Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Quinone
stoichiometric coefficient: 2.0

Water
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Water

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Compound/PW C001170 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Flavin Mononucleotide
stoichiometric coefficient: 1.0

Riboflavin
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000244
xref: Reference/BioCyc RIBOFLAVIN
xref: Reference/ChemSpider 431981
xref: Reference/ChEBI CHEBI 17015
xref: Reference/CAS 83-88-5
xref: Reference/PubChem-compound 493570
xref: Reference/KEGG Compound C00255
chemical formula: C17H20N4O6
molecular weight: 376.13828
structure: ChemicalStructure/PW C000165

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Reference/ChEBI CHEBI 16238
type: UnificationXref
id: CHEBI:16238
db: ChEBI

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Dimethylbenzimidazole
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Dimethylbenzimidazole
name: SubPathwayInput

Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
type: Complex
component stoichiometry: Protein/15784 Cell Membrane/Stoichiometry/2.0
cellular location: Cell Membrane
component: Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Reference/HMDB HMDB0001520
type: UnificationXref
id: HMDB0001520
db: HMDB

Reference/BioCyc FMN
type: UnificationXref
id: FMN
db: BioCyc

Reference/HMDB HMDB0003701
type: UnificationXref
id: HMDB0003701
db: HMDB

Compound/PW C000165 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Riboflavin
stoichiometric coefficient: 1.0

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

2.7.1.26
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000165 Cytoplasm/Stoichiometry/1.0
right: Flavin Mononucleotide
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.1.26
left: Riboflavin
left: Adenosine triphosphate
name: Adenosine triphosphate + Riboflavin → Adenosine diphosphate + Flavin Mononucleotide
conversion direction: LEFT_TO_RIGHT

Reference/PathWhiz PW088230
type: UnificationXref
id: PW088230
db: PathWhiz

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: O4P
molecular weight: 94.95342
structure: ChemicalStructure/PW C001104

Reference/HMDB HMDB0003826
type: UnificationXref
id: HMDB0003826
db: HMDB

Reference/PubChem-compound 4650
type: UnificationXref
id: 4650
db: PubChem-compound

Reference/CAS 582-60-5
type: UnificationXref
id: 582-60-5
db: CAS

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Reaction146069
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000165 Cytoplasm/Stoichiometry/1.0
right: Riboflavin
right: Phosphate
spontaneous: false
left: Flavin Mononucleotide
left: Water
name: Flavin Mononucleotide + Water → Phosphate + Riboflavin
conversion direction: LEFT_TO_RIGHT

2.7.7.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000964 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
right: FAD
right: Pyrophosphate
spontaneous: false
EC number: 2.7.7.2
left: Flavin Mononucleotide
left: Adenosine triphosphate
name: Adenosine triphosphate + Flavin Mononucleotide → FAD + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Tyrosinase
type: ProteinReference
xref: Reference/UniProt Q8WN56
organism: Bos taurus

Reaction146066
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000032 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001170 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000964 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
right: Flavin Mononucleotide
right: Adenosine monophosphate
spontaneous: false
left: Water
left: FAD
name: FAD + Water → Adenosine monophosphate + Flavin Mononucleotide
conversion direction: LEFT_TO_RIGHT

1.14.18.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001860 Melanosome Membrane/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001065 Melanosome Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Melanosome Membrane/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001632 Melanosome Membrane/Stoichiometry/2.0
right: Water
right: Quinone
spontaneous: false
EC number: 1.14.18.1
left: Hydroquinone
left: Oxygen
name: 2 Hydroquinone + Oxygen → 2 Quinone + 2 Water
conversion direction: LEFT_TO_RIGHT

Riboflavin Metabolism
type: Pathway
pathway order: PathwayEnzymeReaction/2112363
pathway order: PathwayEnzymeReaction/2112361
pathway order: PathwayEnzymeReaction/2112362
pathway order: PathwayEnzymeReaction/2112357
pathway order: PathwayEnzymeReaction/2112358
pathway order: PathwayEnzymeReaction/2112359
pathway order: PathwaySubPathway/108202
pathway order: PathwayEnzymeReaction/2112360
pathway order: PathwaySubPathway/108203
pathway order: PathwaySubPathway/108204
pathway component: 2.7.1.26
pathway component: Reaction845
pathway component: Intestinal Microflora
pathway component: Reaction2332
pathway component: ReactionCatalysis136193
pathway component: Reaction146069
pathway component: 2.7.7.2
pathway component: ReactionCatalysis136194
pathway component: Reaction146066
pathway component: ReactionCatalysis136196
pathway component: 1.14.18.1
pathway component: ReactionCatalysis136190
pathway component: ReactionCatalysis136191
xref: Reference/SMPDB SMP0087211
xref: Reference/PathWhiz PW088230
organism: Bos taurus

Riboflavin
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Riboflavin
name: SubPathwayOutput

Reference/GENE ONTOLOGY GO 0033162
type: UnificationXref
id: GO:0033162
db: GENE ONTOLOGY

Quinone
type: SmallMolecule
cellular location: Melanosome Membrane
entity reference: Quinone

Reference/BioCyc 236-TRICHLOROHYDROQUINONE
type: UnificationXref
id: 236-TRICHLOROHYDROQUINONE
db: BioCyc

Reference/KEGG Compound C00472
type: UnificationXref
id: C00472
db: KEGG Compound

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Dimethylbenzimidazole
type: SmallMoleculeReference
xref: Reference/ChemSpider 655
xref: Reference/PubChem-compound 675
xref: Reference/CAS 582-60-5
xref: Reference/HMDB HMDB0003701
xref: Reference/ChEBI CHEBI 15890
xref: Reference/KEGG Compound C03114
chemical formula: C9H10N2
molecular weight: 146.0844
structure: ChemicalStructure/PW C001957

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])([O-])=O

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Reference/HMDB HMDB0004256
type: UnificationXref
id: HMDB0004256
db: HMDB

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Compound/PW C001860 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Quinone
stoichiometric coefficient: 1.0

Reference/CAS 5118-16-1
type: UnificationXref
id: 5118-16-1
db: CAS

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Reference/PubChem-compound 675
type: UnificationXref
id: 675
db: PubChem-compound

Reaction845
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001860 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002109 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001632 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001973 Cytoplasm/Stoichiometry/1.0
right: 7-Hydroxy-6-methyl-8-ribityl lumazine
right: Hydroquinone
spontaneous: true
left: Quinone
left: 6,7-Dimethyl-8-(1-D-ribityl)lumazine
name: 6,7-Dimethyl-8-(1-D-ribityl)lumazine + Quinone → 7-Hydroxy-6-methyl-8-ribityl lumazine + Hydroquinone
conversion direction: LEFT_TO_RIGHT

Compound/PW C000032 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
type: ProteinReference
xref: Reference/UniProt Q0II99
organism: Bos taurus

Low molecular weight phosphotyrosine protein phosphatase
type: Protein
cellular location: Cytoplasm
entity reference: Low molecular weight phosphotyrosine protein phosphatase

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/ChemSpider 559059
type: UnificationXref
id: 559059
db: ChemSpider

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Hydroquinone
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Hydroquinone

Compound/PW C001065 Melanosome Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/PubChem-compound 672
type: UnificationXref
id: 672
db: PubChem-compound

Reference/PubChem-compound 493570
type: UnificationXref
id: 493570
db: PubChem-compound

Reference/ChEBI CHEBI 15890
type: UnificationXref
id: CHEBI:15890
db: ChEBI

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

FAD
type: SmallMolecule
cellular location: Cytoplasm
entity reference: FAD

Compound/PW C002109 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 7-Hydroxy-6-methyl-8-ribityl lumazine
stoichiometric coefficient: 1.0

Reference/ChemSpider 559060
type: UnificationXref
id: 559060
db: ChemSpider

Flavin Mononucleotide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001520
xref: Reference/BioCyc FMN
xref: Reference/ChemSpider 559060
xref: Reference/CAS 146-17-8
xref: Reference/ChEBI CHEBI 17621
xref: Reference/PubChem-compound 643976
xref: Reference/KEGG Compound C00061
chemical formula: C17H21N4O9P
molecular weight: 456.1046
structure: ChemicalStructure/PW C001170

Reference/SMPDB SMP0087211
type: UnificationXref
id: SMP0087211
db: SMPDB

FAD
type: SmallMoleculeReference
xref: Reference/CAS 146-14-5
xref: Reference/HMDB HMDB0001248
xref: Reference/ChEBI CHEBI 16238
xref: Reference/BioCyc FAD
xref: Reference/PubChem-compound 643975
xref: Reference/ChemSpider 559059
xref: Reference/KEGG Compound C00016
chemical formula: C27H33N9O15P2
molecular weight: 785.1571
structure: ChemicalStructure/PW C000964

Compound/PW C001632 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydroquinone
stoichiometric coefficient: 1.0

Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine triphosphate

7-Hydroxy-6-methyl-8-ribityl lumazine
type: SmallMoleculeReference
xref: Reference/CAS 2184-54-5
xref: Reference/ChEBI CHEBI 27581
xref: Reference/HMDB HMDB0004256
xref: Reference/ChemSpider 20100757
xref: Reference/KEGG Compound C05995
chemical formula: C12H16N4O7
molecular weight: 328.1019
structure: ChemicalStructure/PW C002109

Reference/KEGG Compound C00016
type: UnificationXref
id: C00016
db: KEGG Compound

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Reference/KEGG Compound C00255
type: UnificationXref
id: C00255
db: KEGG Compound

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: O7P2
molecular weight: 173.91193
structure: ChemicalStructure/PW C000170

Compound/PW C000964 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: FAD
stoichiometric coefficient: 1.0

Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Adenosine monophosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Adenosine monophosphate

Flavin Mononucleotide
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Flavin Mononucleotide

Reference/ChEBI CHEBI 17015
type: UnificationXref
id: CHEBI:17015
db: ChEBI

Quinone
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Quinone

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

Reference/HMDB HMDB0000244
type: UnificationXref
id: HMDB0000244
db: HMDB

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Reference/BioCyc DIMETHYL-D-RIBITYL-LUMAZINE
type: UnificationXref
id: DIMETHYL-D-RIBITYL-LUMAZINE
db: BioCyc

Reference/ChEBI CHEBI 17621
type: UnificationXref
id: CHEBI:17621
db: ChEBI

Hydroquinone
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0002434
xref: Reference/ChemSpider 764
xref: Reference/PubChem-compound 785
xref: Reference/CAS 123-31-9
xref: Reference/BioCyc 236-TRICHLOROHYDROQUINONE
xref: Reference/ChEBI CHEBI 17594
xref: Reference/KEGG Compound C00530
chemical formula: C6H6O2
molecular weight: 110.03678
structure: ChemicalStructure/PW C001632

ChemicalStructure/PW C000964
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

ChemicalStructure/PW C002109
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0002434
type: UnificationXref
id: HMDB0002434
db: HMDB

FAD synthase
type: Protein
cellular location: Cytoplasm
entity reference: FAD synthase

Reference/ChemSpider 655
type: UnificationXref
id: 655
db: ChemSpider

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

Reference/ChemSpider 652
type: UnificationXref
id: 652
db: ChemSpider

Hydroquinone
type: SmallMolecule
cellular location: Melanosome Membrane
entity reference: Hydroquinone

Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Compound/PW C001170 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Flavin Mononucleotide
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])(=O)OP([O-])([O-])=O

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Water
type: SmallMolecule
cellular location: Melanosome Membrane
entity reference: Water

Water
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Water

FAD
type: SmallMolecule
cellular location: Cell Membrane
entity reference: FAD

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 764
type: UnificationXref
id: 764
db: ChemSpider

Bos taurus
type: BioSource
xref: Reference/TAXONOMY 9913

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Reference/ChEBI CHEBI 17601
type: UnificationXref
id: CHEBI:17601
db: ChEBI

Reference/PubChem-compound 785
type: UnificationXref
id: 785
db: PubChem-compound

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

RFK protein
type: Protein
cellular location: Cytoplasm
entity reference: RFK protein

Reference/PubChem-compound 643976
type: UnificationXref
id: 643976
db: PubChem-compound

Compound/PW C001973 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 6,7-Dimethyl-8-(1-D-ribityl)lumazine
stoichiometric coefficient: 1.0

Reference/CAS 2184-54-5
type: UnificationXref
id: 2184-54-5
db: CAS

Reference/PubChem-compound 643975
type: UnificationXref
id: 643975
db: PubChem-compound

6,7-Dimethyl-8-(1-D-ribityl)lumazine
type: SmallMoleculeReference
xref: Reference/CAS 5118-16-1
xref: Reference/ChEBI CHEBI 17601
xref: Reference/ChemSpider 652
xref: Reference/BioCyc DIMETHYL-D-RIBITYL-LUMAZINE
xref: Reference/HMDB HMDB0003826
xref: Reference/PubChem-compound 672
xref: Reference/KEGG Compound C04332
chemical formula: C13H18N4O6
molecular weight: 326.12262
structure: ChemicalStructure/PW C001973

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Reference/CAS 83-88-5
type: UnificationXref
id: 83-88-5
db: CAS

Quinone
type: SmallMoleculeReference
xref: Reference/ChemSpider 4489
xref: Reference/CAS 106-51-4
xref: Reference/KEGG Compound C00472
xref: Reference/ChEBI CHEBI 16509
xref: Reference/BioCyc CPD-8130
xref: Reference/PubChem-compound 4650
xref: Reference/HMDB HMDB0003364
chemical formula: C6H4O2
molecular weight: 108.021126
structure: ChemicalStructure/PW C001860

Reference/HMDB HMDB0001248
type: UnificationXref
id: HMDB0001248
db: HMDB

Reference/KEGG Compound C00061
type: UnificationXref
id: C00061
db: KEGG Compound

Reference/ChEBI CHEBI 16509
type: UnificationXref
id: CHEBI:16509
db: ChEBI

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine diphosphate

Reference/CAS 146-17-8
type: UnificationXref
id: 146-17-8
db: CAS

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/ChemSpider 4489
type: UnificationXref
id: 4489
db: ChemSpider

Reference/BioCyc CPD-8130
type: UnificationXref
id: CPD-8130
db: BioCyc

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Reference/KEGG Compound C05995
type: UnificationXref
id: C05995
db: KEGG Compound

Pyrophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pyrophosphate

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Reference/BioCyc RIBOFLAVIN
type: UnificationXref
id: RIBOFLAVIN
db: BioCyc

ChemicalStructure/PW C000165
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

Reference/CAS 123-31-9
type: UnificationXref
id: 123-31-9
db: CAS

ReactionCatalysis136193
type: Catalysis
controller: FAD synthase
controlled: 2.7.7.2
control type: ACTIVATION

ReactionCatalysis136194
type: Catalysis
controller: Low molecular weight phosphotyrosine protein phosphatase
controlled: Reaction146069
control type: ACTIVATION

ReactionCatalysis136196
type: Catalysis
controller: RFK protein
controlled: 2.7.1.26
control type: ACTIVATION

ReactionCatalysis136190
type: Catalysis
controller: Tyrosinase
controlled: 1.14.18.1
control type: ACTIVATION

ReactionCatalysis136191
type: Catalysis
controller: Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
controlled: Reaction146066
control type: ACTIVATION

Reference/UniProt F6R6Q1
type: UnificationXref
id: F6R6Q1
db: UniProt

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

FAD synthase
type: ProteinReference
xref: Reference/UniProt F6R6Q1
organism: Bos taurus

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

ChemicalStructure/PW C001860
type: ChemicalStructure
structure format: SMILES
structure data: O=C1C=CC(=O)C=C1

SubPathwayInteraction108202
type: Interaction
name: SubPathway108202Reaction
name: SubPathwayReaction
participant: 6,7-Dimethyl-8-(1-D-ribityl)lumazine

SubPathwayInteraction108203
type: Interaction
name: SubPathway108203Reaction
name: SubPathwayReaction
participant: Riboflavin

Oxygen
type: SmallMolecule
cellular location: Melanosome Membrane
entity reference: Oxygen

Low molecular weight phosphotyrosine protein phosphatase
type: ProteinReference
xref: Reference/UniProt P11064
organism: Bos taurus

SubPathwayInteraction108204
type: Interaction
name: SubPathway108204Reaction
name: SubPathwayReaction
participant: Dimethylbenzimidazole

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

RFK protein
type: ProteinReference
xref: Reference/UniProt Q3SZP4
organism: Bos taurus

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/CAS 146-14-5
type: UnificationXref
id: 146-14-5
db: CAS

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphate

Reference/KEGG Compound C03114
type: UnificationXref
id: C03114
db: KEGG Compound

Protein/15784 Cell Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
stoichiometric coefficient: 2.0

ChemicalStructure/PW C001632
type: ChemicalStructure
structure format: SMILES
structure data: OC1=CC=C(O)C=C1

Compound/PW C001420 Melanosome Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 2.0

Reference/ChEBI CHEBI 27581
type: UnificationXref
id: CHEBI:27581
db: ChEBI

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Reference/UniProt Q0II99
type: UnificationXref
id: Q0II99
db: UniProt

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

Reference/UniProt Q8WN56
type: UnificationXref
id: Q8WN56
db: UniProt

Reference/KEGG Compound C04332
type: UnificationXref
id: C04332
db: KEGG Compound

ChemicalStructure/PW C001957
type: ChemicalStructure
structure format: SMILES
structure data: CC1=CC2=C(C=C1C)N=CN2

Reference/KEGG Compound C00530
type: UnificationXref
id: C00530
db: KEGG Compound

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/BioCyc FAD
type: UnificationXref
id: FAD
db: BioCyc

Reference/UniProt P11064
type: UnificationXref
id: P11064
db: UniProt

6,7-Dimethyl-8-(1-D-ribityl)lumazine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 6,7-Dimethyl-8-(1-D-ribityl)lumazine
name: SubPathwayOutput

7-Hydroxy-6-methyl-8-ribityl lumazine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 7-Hydroxy-6-methyl-8-ribityl lumazine

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Flavin Mononucleotide
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Flavin Mononucleotide

Reference/CAS 106-51-4
type: UnificationXref
id: 106-51-4
db: CAS

Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
type: Protein
cellular location: Cell Membrane
entity reference: Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Reference/ChemSpider 20100757
type: UnificationXref
id: 20100757
db: ChemSpider

Compound/PW C000964 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: FAD
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001973
type: ChemicalStructure
structure format: SMILES

Compound/PW C001632 Melanosome Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Hydroquinone
stoichiometric coefficient: 2.0

ChemicalStructure/PW C001170
type: ChemicalStructure
structure format: SMILES