Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

BiologicalState424
type: BioSource
cell type: Hepatocyte
xref: Reference/TAXONOMY 9913
name: Bos taurus, Liver, Hepatocyte
tissue: Liver

ReactionCatalysis135838
type: Catalysis
controller: Glutamate dehydrogenase 1, mitochondrial
controlled: 1.4.1.3
control type: ACTIVATION

BiologicalState423
type: BioSource
cell type: Myocyte
xref: Reference/TAXONOMY 9913
name: Bos taurus, Muscle, Myocyte
tissue: Muscle

Reference/ChEBI CHEBI 16134
type: UnificationXref
id: CHEBI:16134
db: ChEBI

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Ammonia
type: SmallMoleculeReference
xref: Reference/BioCyc AMMONIA
xref: Reference/CAS 7664-41-7
xref: Reference/HMDB HMDB0000051
xref: Reference/PubChem-compound 222
xref: Reference/KEGG Compound C00014
xref: Reference/ChEBI CHEBI 16134
xref: Reference/ChemSpider 217
chemical formula: H3N
molecular weight: 17.026548
structure: ChemicalStructure/PW C000035

Reference/ChemSpider 50
type: UnificationXref
id: 50
db: ChemSpider

Alanine aminotransferase 1
type: Protein
cellular location: Cytoplasm
entity reference: Alanine aminotransferase 1

Reference/TAXONOMY 9913
type: UnificationXref
id: 9913
db: TAXONOMY

Protein/14943 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Alanine aminotransferase 1
stoichiometric coefficient: 2.0

Reference/PubChem-compound 51
type: UnificationXref
id: 51
db: PubChem-compound

Glycolysis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108215
pathway component: SubPathwayInteraction108215
xref: Reference/SMPDB SMP0000040
xref: Reference/PathWhiz PW000146
name: SubPathway

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Pyruvic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 1060
xref: Reference/HMDB HMDB0000243
xref: Reference/CAS 127-17-3
xref: Reference/BioCyc PYRUVATE
xref: Reference/KEGG Compound C00022
xref: Reference/ChEBI CHEBI 32816
xref: Reference/ChemSpider 1031
chemical formula: C3H4O3
molecular weight: 88.016045
structure: ChemicalStructure/PW C000164

Reference/CELL TYPE ONTOLOGY CL 0000182
type: UnificationXref
id: CL:0000182
db: CELL TYPE ONTOLOGY

Reference/BRENDA TISSUE ONTOLOGY BTO 0000759
type: UnificationXref
id: BTO:0000759
db: BRENDA TISSUE ONTOLOGY

Reference/PathWhiz PW088240
type: UnificationXref
id: PW088240
db: PathWhiz

Compound/PW C000095 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Protein Degradation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108219
pathway component: SubPathwayInteraction108219
name: SubPathway

Reference/CELL TYPE ONTOLOGY CL 0000187
type: UnificationXref
id: CL:0000187
db: CELL TYPE ONTOLOGY

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/PathWhiz PW000162
type: UnificationXref
id: PW000162
db: PathWhiz

Glutamate dehydrogenase 1, mitochondrial
type: Complex
component stoichiometry: Protein/15098 Mitochondrial Matrix/Stoichiometry/6.0
cellular location: Mitochondrial Matrix
component: Glutamate dehydrogenase 1, mitochondrial

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/CAS 2280-44-6
type: UnificationXref
id: 2280-44-6
db: CAS

Reference/BRENDA TISSUE ONTOLOGY BTO 0000887
type: UnificationXref
id: BTO:0000887
db: BRENDA TISSUE ONTOLOGY

Oxoglutaric acid
type: SmallMoleculeReference
xref: Reference/CAS 328-50-7
xref: Reference/PubChem-compound 51
xref: Reference/BioCyc 2-KETOGLUTARATE
xref: Reference/HMDB HMDB0000208
xref: Reference/ChEBI CHEBI 30915
xref: Reference/KEGG Compound C00026
xref: Reference/ChemSpider 50
chemical formula: C5H6O5
molecular weight: 146.02153
structure: ChemicalStructure/PW C000134

Compound/PW C000077 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glucose
stoichiometric coefficient: 1.0

Urea Cycle
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108218
pathway component: SubPathwayInteraction108218
xref: Reference/SMPDB SMP0000059
xref: Reference/PathWhiz PW000162
name: SubPathway

Alanine aminotransferase 1
type: ProteinReference
xref: Reference/UniProt A4IFH5
organism: BiologicalState423

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Glucose-Alanine Cycle
type: Pathway
pathway order: PathwayTransport/2112504
pathway order: PathwayTransport/2112505
pathway order: PathwayTransport/2112506
pathway order: PathwayTransport/2112507
pathway order: PathwayTransport/2112508
pathway order: PathwayEnzymeReaction/2112503
pathway order: PathwaySubPathway/108217
pathway order: PathwaySubPathway/108218
pathway order: PathwayEnzymeReaction/2112501
pathway order: PathwaySubPathway/108219
pathway order: PathwayEnzymeReaction/2112502
pathway order: PathwaySubPathway/108215
pathway order: PathwaySubPathway/108216
pathway component: TransportCatalysis1016
pathway component: TransportCatalysis1015
pathway component: Transport7911
pathway component: Transport7910
pathway component: TransportCatalysis1017
pathway component: ReactionCatalysis135785
pathway component: ReactionCatalysis135784
pathway component: TransportCatalysis1014
pathway component: TransportCatalysis1013
pathway component: Protein Degradation
pathway component: Transport7909
pathway component: Transport7908
pathway component: Transport7907
pathway component: ReactionCatalysis135838
pathway component: 2.6.1.2
pathway component: Aspartate Metabolism
pathway component: 1.4.1.3
pathway component: Glycolysis
pathway component: Gluconeogenesis
pathway component: Urea Cycle
xref: Reference/SMPDB SMP0087221
xref: Reference/PathWhiz PW088240
organism: Bos taurus

Ammonia
type: SmallMolecule
cellular location: Cytosol
entity reference: Ammonia
name: SubPathwayInput

Reference/ChemSpider 5735
type: UnificationXref
id: 5735
db: ChemSpider

Glutamate dehydrogenase 1, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Glutamate dehydrogenase 1, mitochondrial

Reference/PathWhiz PW000152
type: UnificationXref
id: PW000152
db: PathWhiz

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Aspartate Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108216
pathway component: SubPathwayInteraction108216
xref: Reference/PathWhiz PW000002
xref: Reference/SMPDB SMP0000067
name: SubPathway

Reference/ChEBI CHEBI 16977
type: UnificationXref
id: CHEBI:16977
db: ChEBI

Reference/HMDB HMDB0000208
type: UnificationXref
id: HMDB0000208
db: HMDB

L-Glutamic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Glutamic acid
name: SubPathwayOutput

Glutamate dehydrogenase 1, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q8HZ49
organism: BiologicalState424

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/ChemSpider 217
type: UnificationXref
id: 217
db: ChemSpider

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Reference/SMPDB SMP0000040
type: UnificationXref
id: SMP0000040
db: SMPDB

1.4.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Mitochondrial Matrix/Stoichiometry/1.0
right: Ammonia
right: Oxoglutaric acid
right: NADH
spontaneous: false
EC number: 1.4.1.3
left: Water
left: L-Glutamic acid
left: NAD
name: L-Glutamic acid + NAD + Water → Ammonia + NADH + Oxoglutaric acid
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000134
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(=O)C(O)=O

Compound/PW C000134 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxoglutaric acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 30915
type: UnificationXref
id: CHEBI:30915
db: ChEBI

D-Glucose
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000122
xref: Reference/PubChem-compound 5793
xref: Reference/CAS 2280-44-6
xref: Reference/ChemSpider 5589
xref: Reference/ChEBI CHEBI 4167
xref: Reference/BioCyc GLC
xref: Reference/KEGG Compound C00031
chemical formula: C6H12O6
molecular weight: 180.06339
structure: ChemicalStructure/PW C000077

Compound/PW C000035 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonia
stoichiometric coefficient: 1.0

Compound/PW C000077 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glucose
stoichiometric coefficient: 1.0

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Reference/BioCyc L-ALPHA-ALANINE
type: UnificationXref
id: L-ALPHA-ALANINE
db: BioCyc

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/BioCyc GLC
type: UnificationXref
id: GLC
db: BioCyc

Reference/CAS 56-41-7
type: UnificationXref
id: 56-41-7
db: CAS

NADH
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: NADH

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/ChemSpider 1031
type: UnificationXref
id: 1031
db: ChemSpider

Liver
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000759

Myocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000187

Reference/UniProt Q95M41
type: UnificationXref
id: Q95M41
db: UniProt

Reference/GENE ONTOLOGY GO 0005759
type: UnificationXref
id: GO:0005759
db: GENE ONTOLOGY

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

Compound/PW C000164 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 1.0

Reference/CAS 7664-41-7
type: UnificationXref
id: 7664-41-7
db: CAS

Reference/SMPDB SMP0000059
type: UnificationXref
id: SMP0000059
db: SMPDB

Gluconeogenesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108217
pathway component: SubPathwayInteraction108217
xref: Reference/SMPDB SMP0000128
xref: Reference/PathWhiz PW000152
name: SubPathway

Muscle
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000887

Oxoglutaric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxoglutaric acid

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Pyruvic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyruvic acid
name: SubPathwayInput

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H28N7O14P2
molecular weight: 664.11694
structure: ChemicalStructure/PW C000721

ChemicalStructure/PW C000105
type: ChemicalStructure
structure format: SMILES
structure data: C[C@H](N)C(O)=O

Compound/PW C000134 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxoglutaric acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Reference/PubChem-compound 5950
type: UnificationXref
id: 5950
db: PubChem-compound

Reference/PubChem-compound 222
type: UnificationXref
id: 222
db: PubChem-compound

Mitochondrial glutamate carrier 1
type: Protein
entity reference: Mitochondrial glutamate carrier 1

Reference/KEGG Compound C00014
type: UnificationXref
id: C00014
db: KEGG Compound

Hydrogen Ion
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Hydrogen Ion

Alanine aminotransferase 1
type: Complex
component stoichiometry: Protein/14943 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Alanine aminotransferase 1

Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reference/UniProt Q8HZ49
type: UnificationXref
id: Q8HZ49
db: UniProt

D-Glucose
type: SmallMolecule
entity reference: D-Glucose

Reference/SMPDB SMP0000067
type: UnificationXref
id: SMP0000067
db: SMPDB

Hepatocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000182

Pyruvic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pyruvic acid
name: SubPathwayOutput

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/UniProt Q08DK4
type: UnificationXref
id: Q08DK4
db: UniProt

Reference/SMPDB SMP0087221
type: UnificationXref
id: SMP0087221
db: SMPDB

Reference/KEGG Compound C00022
type: UnificationXref
id: C00022
db: KEGG Compound

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

L-Glutamic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Glutamic acid

Reference/KEGG Compound C00026
type: UnificationXref
id: C00026
db: KEGG Compound

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

Reference/HMDB HMDB0000243
type: UnificationXref
id: HMDB0000243
db: HMDB

Reference/HMDB HMDB0000122
type: UnificationXref
id: HMDB0000122
db: HMDB

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Reference/UniProt A6QPH3
type: UnificationXref
id: A6QPH3
db: UniProt

L-Glutamic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: L-Glutamic acid

Reference/SMPDB SMP0000128
type: UnificationXref
id: SMP0000128
db: SMPDB

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00031
type: UnificationXref
id: C00031
db: KEGG Compound

Neutral amino acid transporter A
type: Protein
entity reference: Neutral amino acid transporter A

Compound/PW C000164 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Reference/CAS 328-50-7
type: UnificationXref
id: 328-50-7
db: CAS

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00041
type: UnificationXref
id: C00041
db: KEGG Compound

D-Glucose
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Glucose
name: SubPathwayOutput

Mitochondrial Matrix
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005759

Reference/UniProt A4IFH5
type: UnificationXref
id: A4IFH5
db: UniProt

Alanine aminotransferase 2
type: Complex
component stoichiometry: Protein/14943 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Alanine aminotransferase 1

Solute carrier family 2, facilitated glucose transporter member 2
type: Protein
entity reference: Solute carrier family 2, facilitated glucose transporter member 2

Sodium-coupled neutral amino acid transporter 2
type: Protein
entity reference: Sodium-coupled neutral amino acid transporter 2

2.6.1.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000105 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000105 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Cytoplasm/Stoichiometry/1.0
right: Pyruvic acid
right: L-Glutamic acid
spontaneous: false
EC number: 2.6.1.2
left: Oxoglutaric acid
left: L-Alanine
name: L-Alanine + Oxoglutaric acid ↔ L-Glutamic acid + Pyruvic acid
conversion direction: REVERSIBLE

Solute carrier family 2, facilitated glucose transporter member 4
type: Protein
entity reference: Solute carrier family 2, facilitated glucose transporter member 4

Bos taurus
type: BioSource
xref: Reference/TAXONOMY 9913

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

Compound/PW C000134 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxoglutaric acid
stoichiometric coefficient: 1.0

Protein/14943 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Alanine aminotransferase 1
stoichiometric coefficient: 2.0

Compound/PW C000105 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Alanine
stoichiometric coefficient: 1.0

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Reference/ChemSpider 5589
type: UnificationXref
id: 5589
db: ChemSpider

Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Ammonia
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Ammonia

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Reference/UniProt Q6SI69
type: UnificationXref
id: Q6SI69
db: UniProt

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Reference/CAS 127-17-3
type: UnificationXref
id: 127-17-3
db: CAS

Compound/PW C000095 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Reference/BioCyc AMMONIA
type: UnificationXref
id: AMMONIA
db: BioCyc

ChemicalStructure/PW C000035
type: ChemicalStructure
structure format: SMILES
structure data: N

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

ReactionCatalysis135785
type: Catalysis
controller: Alanine aminotransferase 2
controlled: 2.6.1.2
control type: ACTIVATION

Compound/PW C000077/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glucose
stoichiometric coefficient: 1.0

ReactionCatalysis135784
type: Catalysis
controller: Alanine aminotransferase 1
controlled: 2.6.1.2
control type: ACTIVATION

Compound/PW C000095 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

NAD
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: NAD

ChemicalStructure/PW C000164
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)C(O)=O

Reference/HMDB HMDB0000161
type: UnificationXref
id: HMDB0000161
db: HMDB

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Solute carrier family 2, facilitated glucose transporter member 2
type: ProteinReference
xref: Reference/UniProt A6QPH3

Transport7911
type: Transport
participant stoichiometry: Compound/PW C000105 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000105/Stoichiometry/1.0
right: L-Alanine
spontaneous: false
left: L-Alanine
name: L-Alanine (→) Transport: Bos taurus, Muscle, Myocyte, Cytoplasm to Bos taurus, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Transport7910
type: Transport
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
right: L-Glutamic acid
right: Hydrogen Ion
spontaneous: false
left: Hydrogen Ion
left: L-Glutamic acid
name: L-Glutamic acid (→), Hydrogen Ion (→) Transport: Bos taurus, Liver, Hepatocyte, Cytosol to Bos taurus, Liver, Hepatocyte, Mitochondrial Matrix
conversion direction: LEFT_TO_RIGHT

L-Alanine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00041
xref: Reference/ChemSpider 5735
xref: Reference/ChEBI CHEBI 16977
xref: Reference/BioCyc L-ALPHA-ALANINE
xref: Reference/HMDB HMDB0000161
xref: Reference/CAS 56-41-7
xref: Reference/PubChem-compound 5950
chemical formula: C3H7NO2
molecular weight: 89.047676
structure: ChemicalStructure/PW C000105

Reference/BioCyc 2-KETOGLUTARATE
type: UnificationXref
id: 2-KETOGLUTARATE
db: BioCyc

L-Alanine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Alanine

Reference/PathWhiz PW000146
type: UnificationXref
id: PW000146
db: PathWhiz

Oxoglutaric acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Oxoglutaric acid

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Compound/PW C000105 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Alanine
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Water
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Water

Compound/PW C000105/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Alanine
stoichiometric coefficient: 1.0

L-Alanine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Alanine

Oxoglutaric acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Oxoglutaric acid

Reference/HMDB HMDB0000051
type: UnificationXref
id: HMDB0000051
db: HMDB

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Reference/ChEBI CHEBI 32816
type: UnificationXref
id: CHEBI:32816
db: ChEBI

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Sodium-coupled neutral amino acid transporter 2
type: ProteinReference
xref: Reference/UniProt Q95M41

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

TransportCatalysis1016
type: Catalysis
controller: Mitochondrial glutamate carrier 1
controlled: Transport7910
control type: ACTIVATION

Alanine aminotransferase 1
type: Protein
cellular location: Cytosol
entity reference: Alanine aminotransferase 1

TransportCatalysis1015
type: Catalysis
controller: Solute carrier family 2, facilitated glucose transporter member 4
controlled: Transport7909
control type: ACTIVATION

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

TransportCatalysis1017
type: Catalysis
controller: Neutral amino acid transporter A
controlled: Transport7911
control type: ACTIVATION

Reference/BioCyc PYRUVATE
type: UnificationXref
id: PYRUVATE
db: BioCyc

TransportCatalysis1014
type: Catalysis
controller: Solute carrier family 2, facilitated glucose transporter member 2
controlled: Transport7908
control type: ACTIVATION

TransportCatalysis1013
type: Catalysis
controller: Sodium-coupled neutral amino acid transporter 2
controlled: Transport7907
control type: ACTIVATION

Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Transport7909
type: Transport
participant stoichiometry: Compound/PW C000077/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000077 Cytoplasm/Stoichiometry/1.0
right: D-Glucose
spontaneous: false
left: D-Glucose
name: D-Glucose (→) Transport: Bos taurus, Blood Vessel to Bos taurus, Muscle, Myocyte, Cytoplasm
conversion direction: LEFT_TO_RIGHT

Transport7908
type: Transport
participant stoichiometry: Compound/PW C000077 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000077/Stoichiometry/1.0
right: D-Glucose
spontaneous: false
left: D-Glucose
name: D-Glucose (→) Transport: Bos taurus, Liver, Hepatocyte, Cytosol to Bos taurus, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Transport7907
type: Transport
participant stoichiometry: Compound/PW C000105/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000105 Cytosol/Stoichiometry/1.0
right: L-Alanine
spontaneous: false
left: L-Alanine
name: L-Alanine (→) Transport: Bos taurus, Blood Vessel to Bos taurus, Liver, Hepatocyte, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 4167
type: UnificationXref
id: CHEBI:4167
db: ChEBI

Solute carrier family 2, facilitated glucose transporter member 4
type: ProteinReference
xref: Reference/UniProt Q6SI69

Protein/15098 Mitochondrial Matrix/Stoichiometry/6.0
type: Stoichiometry
physical entity: Glutamate dehydrogenase 1, mitochondrial
stoichiometric coefficient: 6.0

Neutral amino acid transporter A
type: ProteinReference
xref: Reference/UniProt A2VDL4

Reference/PathWhiz PW000002
type: UnificationXref
id: PW000002
db: PathWhiz

Reference/PubChem-compound 5793
type: UnificationXref
id: 5793
db: PubChem-compound

SubPathwayInteraction108216
type: Interaction
name: SubPathway108216Reaction
name: SubPathwayReaction
participant: Pyruvic acid

SubPathwayInteraction108217
type: Interaction
name: SubPathwayReaction
name: SubPathway108217Reaction
participant: Pyruvic acid
participant: D-Glucose

SubPathwayInteraction108218
type: Interaction
name: SubPathwayReaction
name: SubPathway108218Reaction
participant: Ammonia

SubPathwayInteraction108219
type: Interaction
name: SubPathway108219Reaction
name: SubPathwayReaction
participant: L-Glutamic acid

ChemicalStructure/PW C000077
type: ChemicalStructure
structure format: SMILES
structure data: OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Reference/PubChem-compound 1060
type: UnificationXref
id: 1060
db: PubChem-compound

Mitochondrial glutamate carrier 1
type: ProteinReference
xref: Reference/UniProt Q08DK4

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

L-Alanine
type: SmallMolecule
entity reference: L-Alanine

Reference/UniProt A2VDL4
type: UnificationXref
id: A2VDL4
db: UniProt

D-Glucose
type: SmallMolecule
cellular location: Cytoplasm
entity reference: D-Glucose
name: SubPathwayInput

SubPathwayInteraction108215
type: Interaction
name: SubPathway108215Reaction
name: SubPathwayReaction
participant: Pyruvic acid
participant: D-Glucose