Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Compound/PW C002052 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 6-Hydroxymelatonin
stoichiometric coefficient: 1.0

Compound/PW C000935 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: N'-Formylkynurenine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

Reference/CAS 16597-58-3
type: UnificationXref
id: 16597-58-3
db: CAS

Reference/CAS 492-27-3
type: UnificationXref
id: 492-27-3
db: CAS

Reference/ChemSpider 50
type: UnificationXref
id: 50
db: ChemSpider

Reference/TAXONOMY 9913
type: UnificationXref
id: 9913
db: TAXONOMY

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

Reference/ChemSpider 1118
type: UnificationXref
id: 1118
db: ChemSpider

Reference/PubChem-compound 910
type: UnificationXref
id: 910
db: PubChem-compound

RNA/25 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Tryptophyl-tRNA(Trp)
stoichiometric coefficient: 1.0

Reference/BioCyc N-ACETYL-5-METHOXY-TRYPTAMINE
type: UnificationXref
id: N-ACETYL-5-METHOXY-TRYPTAMINE
db: BioCyc

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Reference/KEGG Compound C03722
type: UnificationXref
id: C03722
db: KEGG Compound

NADH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADH

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

5-Hydroxyindoleacetaldehyde
type: SmallMolecule
cellular location: Cytosol
entity reference: 5-Hydroxyindoleacetaldehyde

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/ChEBI CHEBI 995
type: UnificationXref
id: CHEBI:995
db: ChEBI

Reference/UniProt Q2KIQ5
type: UnificationXref
id: Q2KIQ5
db: UniProt

Reference/KEGG Compound C02406
type: UnificationXref
id: C02406
db: KEGG Compound

Reference/ChemSpider 5735
type: UnificationXref
id: 5735
db: ChemSpider

L-Kynurenine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Kynurenine

Reference/ChEBI CHEBI 16240
type: UnificationXref
id: CHEBI:16240
db: ChEBI

Reference/PathWhiz PW000151
type: UnificationXref
id: PW000151
db: PathWhiz

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0004369
type: UnificationXref
id: HMDB0004369
db: HMDB

L-3-Hydroxykynurenine
type: SmallMoleculeReference
xref: Reference/BioCyc 3-HYDROXY-L-KYNURENINE
xref: Reference/ChemSpider 11318
xref: Reference/ChEBI CHEBI 17380
xref: Reference/KEGG Compound C03227
xref: Reference/PubChem-compound 11811
xref: Reference/HMDB HMDB0011631
xref: Reference/CAS 606-14-4
chemical formula: C10H12N2O4
molecular weight: 224.07971
structure: ChemicalStructure/PW C007219

Reference/CAS 708-23-6
type: UnificationXref
id: 708-23-6
db: CAS

Compound/PW C000358 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Hydroxy-L-tryptophan
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0004370
type: UnificationXref
id: HMDB0004370
db: HMDB

Reference/ChEBI CHEBI 28281
type: UnificationXref
id: CHEBI:28281
db: ChEBI

Compound/PW C000609 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Hydroxyindoleacetic acid
stoichiometric coefficient: 1.0

Reference/CAS 979-92-0
type: UnificationXref
id: 979-92-0
db: CAS

Compound/PW C001144 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 5086
type: UnificationXref
id: CHEBI:5086
db: ChEBI

Reference/ChEBI CHEBI 17380
type: UnificationXref
id: CHEBI:17380
db: ChEBI

Reference/ChEBI CHEBI 48294
type: UnificationXref
id: CHEBI:48294
db: ChEBI

Reference/UniProt Q0VCA8
type: UnificationXref
id: Q0VCA8
db: UniProt

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

2-Aminobenzoic acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00108
xref: Reference/ChEBI CHEBI 30754
xref: Reference/HMDB HMDB0001123
xref: Reference/ChemSpider 222
xref: Reference/CAS 118-92-3
xref: Reference/PubChem-compound 227
xref: Reference/BioCyc ANTHRANILATE
chemical formula: C7H7NO2
molecular weight: 137.04768
structure: ChemicalStructure/PW C000877

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/BioCyc L-ALPHA-ALANINE
type: UnificationXref
id: L-ALPHA-ALANINE
db: BioCyc

Reference/CAS 56-41-7
type: UnificationXref
id: 56-41-7
db: CAS

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

NADPH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADPH

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

ChemicalStructure/PW C007219
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC(=O)C1=CC=CC(O)=C1N)C(O)=O

Compound/PW C002053 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid
stoichiometric coefficient: 1.0

Compound/PW C001137 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Hydroxyanthranilic acid
stoichiometric coefficient: 1.0

Compound/PW C002060 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Methoxyindoleacetate
stoichiometric coefficient: 1.0

Reference/ChemSpider 84
type: UnificationXref
id: 84
db: ChemSpider

Reference/ChemSpider 67261
type: UnificationXref
id: 67261
db: ChemSpider

Reference/ChemSpider 388413
type: UnificationXref
id: 388413
db: ChemSpider

Reference/KEGG Compound C00019
type: UnificationXref
id: C00019
db: KEGG Compound

Reference/UniProt O02785
type: UnificationXref
id: O02785
db: UniProt

Coenzyme A
type: SmallMolecule
cellular location: Cytosol
entity reference: Coenzyme A

Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

5-Hydroxyindoleacetic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000763
xref: Reference/PubChem-compound 1826
xref: Reference/BioCyc 5-HYDROXYINDOLE ACETATE
xref: Reference/ChEBI CHEBI 27823
xref: Reference/KEGG Compound C05635
xref: Reference/CAS 54-16-0
xref: Reference/ChemSpider 1760
chemical formula: C10H9NO3
molecular weight: 191.05824
structure: ChemicalStructure/PW C000609

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Reference/PubChem-compound 903
type: UnificationXref
id: 903
db: PubChem-compound

Reference/CAS 59-00-7
type: UnificationXref
id: 59-00-7
db: CAS

Reference/KEGG Compound C00021
type: UnificationXref
id: C00021
db: KEGG Compound

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

L-Glutamic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Glutamic acid

Reference/KEGG Compound C00027
type: UnificationXref
id: C00027
db: KEGG Compound

Reference/KEGG Compound C00026
type: UnificationXref
id: C00026
db: KEGG Compound

Reference/ChEBI CHEBI 50157
type: UnificationXref
id: CHEBI:50157
db: ChEBI

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

Reference/KEGG Compound C01598
type: UnificationXref
id: C01598
db: KEGG Compound

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

Catalase
type: Protein
cellular location: Cytosol
entity reference: Catalase

Reference/KEGG Compound C00272
type: UnificationXref
id: C00272
db: KEGG Compound

Cytochrome P450 2U1
type: Protein
cellular location: Cytosol
entity reference: Cytochrome P450 2U1

NADP
type: SmallMolecule
cellular location: Cytosol
entity reference: NADP

Reference/CAS 1022-31-7
type: UnificationXref
id: 1022-31-7
db: CAS

4a-Hydroxytetrahydrobiopterin
type: SmallMolecule
cellular location: Cytosol
entity reference: 4a-Hydroxytetrahydrobiopterin

Reference/ChemSpider 1760
type: UnificationXref
id: 1760
db: ChemSpider

Compound/PW C001074 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Melatonin
stoichiometric coefficient: 1.0

Formic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Formic acid

2-Aminomuconic acid semialdehyde
type: SmallMolecule
cellular location: Cytosol
entity reference: 2-Aminomuconic acid semialdehyde

Reference/KEGG Compound C00041
type: UnificationXref
id: C00041
db: KEGG Compound

Reference/UniProt Q28123
type: UnificationXref
id: Q28123
db: UniProt

ChemicalStructure/PW C001026
type: ChemicalStructure
structure format: SMILES
structure data: N\C(C(O)=O)=C(\C=C/C=O)/C(O)=O

Reference/BioCyc TETRA-H-BIOPTERIN
type: UnificationXref
id: TETRA-H-BIOPTERIN
db: BioCyc

ChemicalStructure/PW C000178
type: ChemicalStructure
structure format: SMILES
structure data: NCCC1=CNC2=C1C=C(O)C=C2

Reference/UniProt Q3SZ80
type: UnificationXref
id: Q3SZ80
db: UniProt

ChemicalStructure/PW C002112
type: ChemicalStructure
structure format: SMILES
structure data: COC1=CC(C(=O)CCNC(C)=O)=C(NC=O)C=C1

Reference/KEGG Compound C15522
type: UnificationXref
id: C15522
db: KEGG Compound

6-Hydroxymelatonin
type: SmallMolecule
cellular location: Cytosol
entity reference: 6-Hydroxymelatonin

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/KEGG Compound C04409
type: UnificationXref
id: C04409
db: KEGG Compound

Reference/CAS 606-59-7
type: UnificationXref
id: 606-59-7
db: CAS

Reference/ChemSpider 886
type: UnificationXref
id: 886
db: ChemSpider

Reference/HMDB HMDB0001476
type: UnificationXref
id: HMDB0001476
db: HMDB

Reference/KEGG Compound C02470
type: UnificationXref
id: C02470
db: KEGG Compound

Reference/CAS 52450-38-1
type: UnificationXref
id: 52450-38-1
db: CAS

Reference/HMDB HMDB0001238
type: UnificationXref
id: HMDB0001238
db: HMDB

Compound/PW C000134 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxoglutaric acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

Compound/PW C002112 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-N-formyl-5-methoxykynurenamine
stoichiometric coefficient: 1.0

Reference/BioCyc 2-AMINO-3-CARBOXYMUCONATE SEMIAL
type: UnificationXref
id: 2-AMINO-3-CARBOXYMUCONATE_SEMIAL
db: BioCyc

L-Tryptophyl-tRNA(Trp)
type: RnaReference
xref: Reference/ChEBI CHEBI 29159
organism: Bos taurus

Reference/HMDB HMDB0000142
type: UnificationXref
id: HMDB0000142
db: HMDB

Xanthurenic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Xanthurenic acid

Reference/PubChem-compound 784
type: UnificationXref
id: 784
db: PubChem-compound

Reference/KEGG Compound C00058
type: UnificationXref
id: C00058
db: KEGG Compound

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Reference/ChEBI CHEBI 29159
type: UnificationXref
id: CHEBI:29159
db: ChEBI

ChemicalStructure/PW C000156
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C1=CC=CN=C1C(O)=O

Reference/UniProt E1BLL5
type: UnificationXref
id: E1BLL5
db: UniProt

Reference/BioCyc FORMATE
type: UnificationXref
id: FORMATE
db: BioCyc

Formyl-5-hydroxykynurenamine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 28736
xref: Reference/ChemSpider 389614
xref: Reference/HMDB HMDB0012948
xref: Reference/KEGG Compound C05647
xref: Reference/CAS 958733-17-0
xref: Reference/PubChem-compound 440743
chemical formula: C10H12N2O3
molecular weight: 208.0848
structure: ChemicalStructure/PW C008135

Reference/ChemSpider 3712
type: UnificationXref
id: 3712
db: ChemSpider

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Compound/PW C000703 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Xanthurenic acid
stoichiometric coefficient: 1.0

Reference/UniProt Q0IIF9
type: UnificationXref
id: Q0IIF9
db: UniProt

Pyrophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pyrophosphate

Reference/HMDB HMDB0000161
type: UnificationXref
id: HMDB0000161
db: HMDB

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChemSpider 31983
type: UnificationXref
id: 31983
db: ChemSpider

Reference/CAS 17528-72-2
type: UnificationXref
id: 17528-72-2
db: CAS

L-Alanine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Alanine

Reference/KEGG Compound C00078
type: UnificationXref
id: C00078
db: KEGG Compound

Reference/ChemSpider 114908
type: UnificationXref
id: 114908
db: ChemSpider

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Melatonin
type: SmallMolecule
cellular location: Cytosol
entity reference: Melatonin

Protein/15701 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
stoichiometric coefficient: 2.0

Reference/CAS 54-16-0
type: UnificationXref
id: 54-16-0
db: CAS

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/ChemSpider 1794
type: UnificationXref
id: 1794
db: ChemSpider

Reference/ChEBI CHEBI 18086
type: UnificationXref
id: CHEBI:18086
db: ChEBI

Reference/CAS 1892-21-3
type: UnificationXref
id: 1892-21-3
db: CAS

Compound/PW C000566 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Kynurenic acid
stoichiometric coefficient: 1.0

Compound/PW C000538 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Kynurenine
stoichiometric coefficient: 1.0

Reference/BioCyc 2-AMINOMUCONATE SEMIALDEHYDE
type: UnificationXref
id: 2-AMINOMUCONATE_SEMIALDEHYDE
db: BioCyc

ChemicalStructure/PW C001074
type: ChemicalStructure
structure format: SMILES
structure data: COC1=CC2=C(NC=C2CCNC(C)=O)C=C1

Tryptamine
type: SmallMoleculeReference
xref: Reference/CAS 61-54-1
xref: Reference/PubChem-compound 1150
xref: Reference/ChEBI CHEBI 16765
xref: Reference/HMDB HMDB0000303
xref: Reference/ChemSpider 1118
xref: Reference/BioCyc TRYPTAMINE
xref: Reference/KEGG Compound C00398
chemical formula: C10H12N2
molecular weight: 160.10005
structure: ChemicalStructure/PW C000207

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Reference/CAS 64-18-6
type: UnificationXref
id: 64-18-6
db: CAS

Reference/ChemSpider 879
type: UnificationXref
id: 879
db: ChemSpider

Reference/ChemSpider 872
type: UnificationXref
id: 872
db: ChemSpider

4a-Hydroxytetrahydrobiopterin
type: SmallMoleculeReference
xref: Reference/CAS 70110-58-6
xref: Reference/PubChem-compound 129803
xref: Reference/KEGG Compound C15522
xref: Reference/ChemSpider 114908
xref: Reference/HMDB HMDB0002281
xref: Reference/ChEBI CHEBI 15374
chemical formula: C9H15N5O4
molecular weight: 257.1124
structure: ChemicalStructure/PW C001541

ChemicalStructure/PW C002132
type: ChemicalStructure
structure format: SMILES
structure data: CNCCC1=CNC2=C1C=C(O)C=C2

Hydrogen peroxide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003125
xref: Reference/PubChem-compound 784
xref: Reference/ChemSpider 763
xref: Reference/CAS 7722-84-1
xref: Reference/BioCyc HYDROGEN-PEROXIDE
xref: Reference/ChEBI CHEBI 16240
xref: Reference/KEGG Compound C00027
chemical formula: H2O2
molecular weight: 34.005478
structure: ChemicalStructure/PW C001783

ChemicalStructure/PW C002133
type: ChemicalStructure
structure format: SMILES
structure data: CNCCC1=CNC2=CC=CC=C12

Reference/HMDB HMDB0001280
type: UnificationXref
id: HMDB0001280
db: HMDB

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Reference/CAS 3517-61-1
type: UnificationXref
id: 3517-61-1
db: CAS

Reference/HMDB HMDB0000197
type: UnificationXref
id: HMDB0000197
db: HMDB

Transport7924
type: Transport
participant stoichiometry: Compound/PW C000741 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000741 Extracellular Space/Stoichiometry/1.0
right: L-Tryptophan
spontaneous: false
left: L-Tryptophan
name: L-Tryptophan (→) Transport: Bos taurus, Extracellular Space to Bos taurus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 141580
type: UnificationXref
id: 141580
db: ChemSpider

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Catalase
type: Complex
component stoichiometry: Protein/15517 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Catalase

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Reference/ChemSpider 144400
type: UnificationXref
id: 144400
db: ChemSpider

Reference/CAS 958733-17-0
type: UnificationXref
id: 958733-17-0
db: CAS

ChemicalStructure/PW C000207
type: ChemicalStructure
structure format: SMILES
structure data: NCCC1=CNC2=C1C=CC=C2

ChemicalStructure/PW C001541
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C001783
type: ChemicalStructure
structure format: SMILES
structure data: OO

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

Reference/PubChem-compound 101399
type: UnificationXref
id: 101399
db: PubChem-compound

Compound/PW C001065 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/PubChem-compound 1125
type: UnificationXref
id: 1125
db: PubChem-compound

Reference/PathWhiz PW088256
type: UnificationXref
id: PW088256
db: PathWhiz

Reference/ChEBI CHEBI 2065
type: UnificationXref
id: CHEBI:2065
db: ChEBI

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Reference/HMDB HMDB0000303
type: UnificationXref
id: HMDB0000303
db: HMDB

Reference/UniProt Q3T099
type: UnificationXref
id: Q3T099
db: UniProt

Reference/PubChem-compound 51
type: UnificationXref
id: 51
db: PubChem-compound

ReactionCatalysis136586
type: Catalysis
controller: Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
controlled: Reaction146434
control type: ACTIVATION

ReactionCatalysis136587
type: Catalysis
controller: 3,4-Dihydroxyphenylacetaldehyde
controlled: 1.13.11.6
control type: ACTIVATION

Compound/PW C000128 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Indoleacetic acid
stoichiometric coefficient: 1.0

ReactionCatalysis136588
type: Catalysis
controller: 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
controlled: 4.1.1.45
control type: ACTIVATION

Reference/PubChem-compound 1150
type: UnificationXref
id: 1150
db: PubChem-compound

ReactionCatalysis136589
type: Catalysis
controller: Phenylalanine-4-hydroxylase
controlled: 1.14.16.4
control type: ACTIVATION

ReactionCatalysis136582
type: Catalysis
controller: Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
controlled: Reaction146430
control type: ACTIVATION

ReactionCatalysis136583
type: Catalysis
controller: Kynurenine 3-monooxygenase
controlled: 1.14.13.9
control type: ACTIVATION

ReactionCatalysis136584
type: Catalysis
controller: Kynureninase
controlled: 3.7.1.3
control type: ACTIVATION

ReactionCatalysis136585
type: Catalysis
controller: Catalase
controlled: 1.11.1.6
control type: ACTIVATION

Reference/ChemSpider 278
type: UnificationXref
id: 278
db: ChemSpider

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

ReactionCatalysis136580
type: Catalysis
controller: Kynurenine formamidase
controlled: 3.5.1.9
control type: ACTIVATION

ReactionCatalysis136581
type: Catalysis
controller: Kynureninase
controlled: 3.7.1.3
control type: ACTIVATION

Reference/PubChem-compound 86
type: UnificationXref
id: 86
db: PubChem-compound

ReactionCatalysis136597
type: Catalysis
controller: Kynurenine 3-monooxygenase
controlled: 1.14.13.9
control type: ACTIVATION

ReactionCatalysis136598
type: Catalysis
controller: Serotonin N-acetyltransferase
controlled: 2.3.1.87
control type: ACTIVATION

ReactionCatalysis136599
type: Catalysis
controller: Acetylserotonin O-methyltransferase
controlled: 2.1.1.4
control type: ACTIVATION

Tetrahydrobiopterin
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00272
xref: Reference/HMDB HMDB0000027
xref: Reference/CAS 17528-72-2
xref: Reference/BioCyc TETRA-H-BIOPTERIN
xref: Reference/PubChem-compound 1125
xref: Reference/ChemSpider 1093
xref: Reference/ChEBI CHEBI 15372
chemical formula: C9H15N5O3
molecular weight: 241.1175
structure: ChemicalStructure/PW C000019

ReactionCatalysis136593
type: Catalysis
controller: Acetylserotonin O-methyltransferase
controlled: 2.1.1.4
control type: ACTIVATION

ReactionCatalysis136594
type: Catalysis
controller: Kynurenine formamidase
controlled: 3.5.1.9
control type: ACTIVATION

ReactionCatalysis136595
type: Catalysis
controller: Indoleamine 2,3-dioxygenase 1
controlled: 1.13.11.52
control type: ACTIVATION

ReactionCatalysis136596
type: Catalysis
controller: Aromatic-L-amino-acid decarboxylase
controlled: 4.1.1.28
control type: ACTIVATION

Reference/CAS 485-80-3
type: UnificationXref
id: 485-80-3
db: CAS

Aldehyde dehydrogenase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q1LZC6
organism: Bos taurus

Reference/KEGG Compound C06212
type: UnificationXref
id: C06212
db: KEGG Compound

Compound/PW C002048 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Hydroxykynurenamine
stoichiometric coefficient: 1.0

ReactionCatalysis136590
type: Catalysis
controller: Aromatic-L-amino-acid decarboxylase
controlled: 4.1.1.28
control type: ACTIVATION

ReactionCatalysis136591
type: Catalysis
controller: Kynurenine 3-monooxygenase
controlled: 1.14.13.9
control type: ACTIVATION

ReactionCatalysis136592
type: Catalysis
controller: Aldehyde dehydrogenase, mitochondrial
controlled: 1.2.1.3
control type: ACTIVATION

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Reaction1615
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000778 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000566 Cytosol/Stoichiometry/1.0
right: Kynurenic acid
spontaneous: false
left: 4-(2-Aminophenyl)-2,4-dioxobutanoic acid
name: 4-(2-Aminophenyl)-2,4-dioxobutanoic acid → Kynurenic acid
conversion direction: LEFT_TO_RIGHT

Carbon dioxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbon dioxide

Cinnavalininate
type: SmallMolecule
cellular location: Cytosol
entity reference: Cinnavalininate

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Reference/PubChem-compound 440745
type: UnificationXref
id: 440745
db: PubChem-compound

Reference/PubChem-compound 440744
type: UnificationXref
id: 440744
db: PubChem-compound

Reference/ChemSpider 459
type: UnificationXref
id: 459
db: ChemSpider

Reference/PubChem-compound 440743
type: UnificationXref
id: 440743
db: PubChem-compound

Reference/KEGG Compound C06213
type: UnificationXref
id: C06213
db: KEGG Compound

Reference/UniProt E1BN59
type: UnificationXref
id: E1BN59
db: UniProt

Reference/PubChem-compound 440741
type: UnificationXref
id: 440741
db: PubChem-compound

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

Reference/ChEBI CHEBI 30915
type: UnificationXref
id: CHEBI:30915
db: ChEBI

Reference/SMPDB SMP0000048
type: UnificationXref
id: SMP0000048
db: SMPDB

Serotonin N-acetyltransferase
type: ProteinReference
xref: Reference/UniProt O02785
organism: Bos taurus

Phenylethanolamine N-methyltransferase
type: Protein
cellular location: Cytosol
entity reference: Phenylethanolamine N-methyltransferase

ReactionCatalysis136577
type: Catalysis
controller: Tryptophan 2,3-dioxygenase
controlled: 1.13.11.11
control type: ACTIVATION

ReactionCatalysis136578
type: Catalysis
controller: Kynureninase
controlled: 3.7.1.3
control type: ACTIVATION

ChemicalStructure/PW C000019
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 440738
type: UnificationXref
id: 440738
db: PubChem-compound

ReactionCatalysis136579
type: Catalysis
controller: Kynurenine formamidase
controlled: 3.5.1.9
control type: ACTIVATION

Reference/CAS 548-93-6
type: UnificationXref
id: 548-93-6
db: CAS

Reduced flavoprotein
type: Protein
cellular location: Cytosol
entity reference: Reduced flavoprotein

Reference/PubChem-compound 5280673
type: UnificationXref
id: 5280673
db: PubChem-compound

Protein/16522 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: 3-hydroxyanthranilate 3,4-dioxygenase
stoichiometric coefficient: 2.0

Reference/CAS 2591-98-2
type: UnificationXref
id: 2591-98-2
db: CAS

Compound/PW C000741 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Tryptophan
stoichiometric coefficient: 1.0

Reference/BioCyc INDOLE ACETALDEHYDE
type: UnificationXref
id: INDOLE_ACETALDEHYDE
db: BioCyc

Oxoglutaric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxoglutaric acid

Reference/ChEBI CHEBI 15745
type: UnificationXref
id: CHEBI:15745
db: ChEBI

3-Hydroxyanthranilic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001476
xref: Reference/BioCyc 3-HYDROXY-ANTHRANILATE
xref: Reference/PubChem-compound 86
xref: Reference/KEGG Compound C00632
xref: Reference/ChemSpider 84
xref: Reference/CAS 548-93-6
xref: Reference/ChEBI CHEBI 15793
chemical formula: C7H7NO3
molecular weight: 153.04259
structure: ChemicalStructure/PW C001137

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Reference/PubChem-compound 5950
type: UnificationXref
id: 5950
db: PubChem-compound

Reference/BioCyc N-ACETYL-SEROTONIN
type: UnificationXref
id: N-ACETYL-SEROTONIN
db: BioCyc

4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid

Reference/HMDB HMDB0001200
type: UnificationXref
id: HMDB0001200
db: HMDB

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/ChEBI CHEBI 16828
type: UnificationXref
id: CHEBI:16828
db: ChEBI

4,6-Dihydroxyquinoline
type: SmallMolecule
cellular location: Cytosol
entity reference: 4,6-Dihydroxyquinoline

Compound/PW C002050 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cinnavalininate
stoichiometric coefficient: 1.0

Reference/ChemSpider 222
type: UnificationXref
id: 222
db: ChemSpider

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

tRNA(Trp)
type: RnaReference
xref: Reference/INSDC 948275
organism: Bos taurus

Reaction1622
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001026 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000156 Cytosol/Stoichiometry/1.0
right: Quinolinic acid
spontaneous: false
left: 2-Amino-3-carboxymuconic acid semialdehyde
name: 2-Amino-3-carboxymuconic acid semialdehyde → Quinolinic acid
conversion direction: LEFT_TO_RIGHT

Reaction1620
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002053 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000703 Cytosol/Stoichiometry/1.0
right: Xanthurenic acid
spontaneous: false
left: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid
name: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid → Xanthurenic acid
conversion direction: LEFT_TO_RIGHT

Indoleamine 2,3-dioxygenase 1
type: Protein
cellular location: Cytosol
entity reference: Indoleamine 2,3-dioxygenase 1

Reference/ChEBI CHEBI 16411
type: UnificationXref
id: CHEBI:16411
db: ChEBI

ChemicalStructure/PW C000609
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC1=CNC2=C1C=C(O)C=C2

Reference/KEGG Compound C00954
type: UnificationXref
id: C00954
db: KEGG Compound

Protein/Generic37 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Reduced flavoprotein
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000929
type: UnificationXref
id: HMDB0000929
db: HMDB

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 440741
xref: Reference/ChemSpider 389612
xref: Reference/HMDB HMDB0004083
xref: Reference/KEGG Compound C05645
chemical formula: C10H9NO5
molecular weight: 223.04807
structure: ChemicalStructure/PW C002053

Reference/CAS 87-51-4
type: UnificationXref
id: 87-51-4
db: CAS

5-Hydroxy-N-formylkynurenine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 2065
xref: Reference/ChemSpider 389615
xref: Reference/HMDB HMDB0004086
xref: Reference/KEGG Compound C05648
xref: Reference/PubChem-compound 440744
chemical formula: C11H12N2O5
molecular weight: 252.07462
structure: ChemicalStructure/PW C002055

L-Tryptophan
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Tryptophan

Formylanthranilic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 101399
xref: Reference/ChemSpider 91624
xref: Reference/CAS 3342-77-6
xref: Reference/KEGG Compound C05653
xref: Reference/ChEBI CHEBI 36575
xref: Reference/HMDB HMDB0004089
chemical formula: C8H7NO3
molecular weight: 165.04259
structure: ChemicalStructure/PW C002057

Cinnavalininate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C05640
xref: Reference/ChemSpider 102864
xref: Reference/CAS 606-59-7
xref: Reference/HMDB HMDB0004078
xref: Reference/PubChem-compound 114918
chemical formula: C14H8N2O6
molecular weight: 300.03824
structure: ChemicalStructure/PW C002050

6-Hydroxymelatonin
type: SmallMoleculeReference
xref: Reference/PubChem-compound 1864
xref: Reference/ChEBI CHEBI 308079
xref: Reference/ChemSpider 1794
xref: Reference/HMDB HMDB0004081
xref: Reference/CAS 2208-41-5
xref: Reference/KEGG Compound C05643
chemical formula: C13H16N2O3
molecular weight: 248.11609
structure: ChemicalStructure/PW C002052

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Compound/PW C001026 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Amino-3-carboxymuconic acid semialdehyde
stoichiometric coefficient: 1.0

Reference/CAS 4350-09-8
type: UnificationXref
id: 4350-09-8
db: CAS

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Compound/PW C000926 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Indoleacetaldehyde
stoichiometric coefficient: 1.0

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

N'-Formylkynurenine
type: SmallMolecule
cellular location: Cytosol
entity reference: N'-Formylkynurenine

Reference/HMDB HMDB0000939
type: UnificationXref
id: HMDB0000939
db: HMDB

Compound/PW C000105 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Alanine
stoichiometric coefficient: 1.0

Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
type: Protein
cellular location: Cytosol
entity reference: Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial

Compound/PW C001420 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 2.0

Compound/PW C000178 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Serotonin
stoichiometric coefficient: 1.0

5-Methoxyindoleacetate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C05660
xref: Reference/ChEBI CHEBI 28281
xref: Reference/CAS 3471-31-6
xref: Reference/HMDB HMDB0004096
xref: Reference/ChemSpider 17924
xref: Reference/PubChem-compound 18986
chemical formula: C11H11NO3
molecular weight: 205.0739
structure: ChemicalStructure/PW C002060

Kynurenine 3-monooxygenase
type: ProteinReference
xref: Reference/UniProt E1BN59
organism: Bos taurus

Reference/HMDB HMDB0004073
type: UnificationXref
id: HMDB0004073
db: HMDB

2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
type: ProteinReference
xref: Reference/UniProt Q0II68
organism: Bos taurus

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

Reference/KEGG Compound C00978
type: UnificationXref
id: C00978
db: KEGG Compound

Reference/PubChem-compound 18986
type: UnificationXref
id: 18986
db: PubChem-compound

Formic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 30751
xref: Reference/ChemSpider 278
xref: Reference/PubChem-compound 18971002
xref: Reference/BioCyc FORMATE
xref: Reference/CAS 64-18-6
xref: Reference/KEGG Compound C00058
xref: Reference/HMDB HMDB0000142
chemical formula: CH2O2
molecular weight: 46.005478
structure: ChemicalStructure/PW C000092

Reference/HMDB HMDB0004077
type: UnificationXref
id: HMDB0004077
db: HMDB

Reference/HMDB HMDB0004076
type: UnificationXref
id: HMDB0004076
db: HMDB

Catalase
type: ProteinReference
xref: Reference/UniProt Q3SZ80
organism: Bos taurus

Kynurenine formamidase
type: ProteinReference
xref: Reference/UniProt E1BLL5
organism: Bos taurus

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Reference/HMDB HMDB0004078
type: UnificationXref
id: HMDB0004078
db: HMDB

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

L-3-Hydroxykynurenine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-3-Hydroxykynurenine

Reference/BioCyc 3-HYDROXY-L-KYNURENINE
type: UnificationXref
id: 3-HYDROXY-L-KYNURENINE
db: BioCyc

Compound/PW C002047 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Hydroxyindoleacetaldehyde
stoichiometric coefficient: 1.0

Indoleamine 2,3-dioxygenase 1
type: ProteinReference
xref: Reference/UniProt F1N7C5
organism: Bos taurus

Reference/HMDB HMDB0004083
type: UnificationXref
id: HMDB0004083
db: HMDB

Reference/UniProt Q0II68
type: UnificationXref
id: Q0II68
db: UniProt

Reference/HMDB HMDB0004081
type: UnificationXref
id: HMDB0004081
db: HMDB

5-Hydroxy-N-formylkynurenine
type: SmallMolecule
cellular location: Cytosol
entity reference: 5-Hydroxy-N-formylkynurenine

Reference/HMDB HMDB0000715
type: UnificationXref
id: HMDB0000715
db: HMDB

Reference/ChemSpider 1093
type: UnificationXref
id: 1093
db: ChemSpider

Compound/PW C002057 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Formylanthranilic acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15793
type: UnificationXref
id: CHEBI:15793
db: ChEBI

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

4-(2-Aminophenyl)-2,4-dioxobutanoic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: 4-(2-Aminophenyl)-2,4-dioxobutanoic acid

5-Hydroxyindoleacetaldehyde
type: SmallMoleculeReference
xref: Reference/PubChem-compound 74688
xref: Reference/HMDB HMDB0004073
xref: Reference/KEGG Compound C05634
xref: Reference/CAS 1892-21-3
xref: Reference/ChEBI CHEBI 50157
xref: Reference/ChemSpider 67261
chemical formula: C10H9NO2
molecular weight: 175.06332
structure: ChemicalStructure/PW C002047

5-Hydroxykynurenamine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 164719
xref: Reference/KEGG Compound C05638
xref: Reference/ChEBI CHEBI 28715
xref: Reference/CAS 708-23-6
xref: Reference/HMDB HMDB0004076
xref: Reference/ChemSpider 144400
chemical formula: C9H12N2O2
molecular weight: 180.08987
structure: ChemicalStructure/PW C002048

4,6-Dihydroxyquinoline
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 28799
xref: Reference/KEGG Compound C05639
xref: Reference/HMDB HMDB0004077
xref: Reference/PubChem-compound 440738
xref: Reference/ChemSpider 389609
xref: Reference/CAS 3517-61-1
chemical formula: C9H7NO2
molecular weight: 161.04768
structure: ChemicalStructure/PW C002049

L-Tryptophan
type: SmallMolecule
cellular location: Extracellular Space
entity reference: L-Tryptophan

Reference/HMDB HMDB0004086
type: UnificationXref
id: HMDB0004086
db: HMDB

Reference/HMDB HMDB0004089
type: UnificationXref
id: HMDB0004089
db: HMDB

Acetylserotonin O-methyltransferase
type: ProteinReference
xref: Reference/UniProt Q28123
organism: Bos taurus

Reference/BioCyc 2-KETOGLUTARATE
type: UnificationXref
id: 2-KETOGLUTARATE
db: BioCyc

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

Reference/ChEBI CHEBI 17780
type: UnificationXref
id: CHEBI:17780
db: ChEBI

Reference/BioCyc L-KYNURENINE
type: UnificationXref
id: L-KYNURENINE
db: BioCyc

Reference/ChEBI CHEBI 30754
type: UnificationXref
id: CHEBI:30754
db: ChEBI

Reference/ChEBI CHEBI 30751
type: UnificationXref
id: CHEBI:30751
db: ChEBI

1.13.11.52
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000741 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000935 Cytosol/Stoichiometry/1.0
right: N'-Formylkynurenine
spontaneous: false
EC number: 1.13.11.52
left: Oxygen
left: L-Tryptophan
name: L-Tryptophan + Oxygen → N'-Formylkynurenine
conversion direction: LEFT_TO_RIGHT

Reaction146456
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002047 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000609 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: 5-Hydroxyindoleacetic acid
right: Hydrogen peroxide
spontaneous: false
left: Oxygen
left: 5-Hydroxyindoleacetaldehyde
left: Water
name: 5-Hydroxyindoleacetaldehyde + Oxygen + Water → 5-Hydroxyindoleacetic acid + Hydrogen peroxide
conversion direction: LEFT_TO_RIGHT

Reaction146455
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000749 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002133 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000207 Cytosol/Stoichiometry/1.0
right: S-Adenosylhomocysteine
right: N-Methyltryptamine
spontaneous: false
left: Tryptamine
left: S-Adenosylmethionine
name: S-Adenosylmethionine + Tryptamine → N-Methyltryptamine + S-Adenosylhomocysteine
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C008135
type: ChemicalStructure
structure format: SMILES
structure data: NCCC(=O)C1=C(NC=O)C=CC(O)=C1

1.2.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000128 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000926 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytosol/Stoichiometry/1.0
right: Indoleacetic acid
right: NADH
spontaneous: false
EC number: 1.2.1.3
left: NAD
left: Indoleacetaldehyde
left: Water
name: Indoleacetaldehyde + NAD + Water → Indoleacetic acid + NADH
conversion direction: LEFT_TO_RIGHT

Acetyl-N-formyl-5-methoxykynurenamine
type: SmallMolecule
cellular location: Cytosol
entity reference: Acetyl-N-formyl-5-methoxykynurenamine

1.14.13.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000926 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000207 Cytosol/Stoichiometry/1.0
right: Indoleacetaldehyde
right: NADP
right: Water
spontaneous: false
EC number: 1.14.13.9
left: Oxygen
left: Tryptamine
left: NADPH
name: NADPH + Oxygen + Tryptamine → Indoleacetaldehyde + NADP + Water
conversion direction: LEFT_TO_RIGHT

4.1.1.28
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000741 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000207 Cytosol/Stoichiometry/1.0
right: Tryptamine
right: Carbon dioxide
spontaneous: false
EC number: 4.1.1.28
left: L-Tryptophan
name: L-Tryptophan → Carbon dioxide + Tryptamine
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0004096
type: UnificationXref
id: HMDB0004096
db: HMDB

1.13.11.52
type: BiochemicalReaction
participant stoichiometry: Compound/PW C008135 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000178 Cytosol/Stoichiometry/1.0
right: Formyl-5-hydroxykynurenamine
spontaneous: false
EC number: 1.13.11.52
left: Oxygen
left: Serotonin
name: Oxygen + Serotonin → Formyl-5-hydroxykynurenamine
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0012948
type: UnificationXref
id: HMDB0012948
db: HMDB

Reaction146450
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000749 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002132 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000178 Cytosol/Stoichiometry/1.0
right: S-Adenosylhomocysteine
right: N-Methylserotonin
spontaneous: false
left: Serotonin
left: S-Adenosylmethionine
name: S-Adenosylmethionine + Serotonin → N-Methylserotonin + S-Adenosylhomocysteine
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q32KQ6
organism: Bos taurus

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Compound/PW C000991 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Aminomuconic acid semialdehyde
stoichiometric coefficient: 1.0

Quinolinic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Quinolinic acid
name: SubPathwayInput

Reference/HMDB HMDB0000978
type: UnificationXref
id: HMDB0000978
db: HMDB

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0011631
type: UnificationXref
id: HMDB0011631
db: HMDB

Reference/ChEBI CHEBI 15372
type: UnificationXref
id: CHEBI:15372
db: ChEBI

Reference/ChEBI CHEBI 15374
type: UnificationXref
id: CHEBI:15374
db: ChEBI

Oxygen
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxygen

1.13.11.52
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002112 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001074 Cytosol/Stoichiometry/1.0
right: Acetyl-N-formyl-5-methoxykynurenamine
spontaneous: false
EC number: 1.13.11.52
left: Oxygen
left: Melatonin
name: Melatonin + Oxygen → Acetyl-N-formyl-5-methoxykynurenamine
conversion direction: LEFT_TO_RIGHT

1.14.14.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002052 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/Generic38 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/Generic37 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001074 Cytosol/Stoichiometry/1.0
right: 6-Hydroxymelatonin
right: Oxidized flavoprotein
right: Water
spontaneous: false
EC number: 1.14.14.1
left: Oxygen
left: Reduced flavoprotein
left: Melatonin
name: Melatonin + Oxygen + Reduced flavoprotein → 6-Hydroxymelatonin + Oxidized flavoprotein + Water
conversion direction: LEFT_TO_RIGHT

Tryptophan--tRNA ligase, cytoplasmic
type: Protein
cellular location: Cytoplasm
entity reference: Tryptophan--tRNA ligase, cytoplasmic

2.1.1.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000956 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000749 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001074 Cytosol/Stoichiometry/1.0
right: S-Adenosylhomocysteine
right: Melatonin
spontaneous: false
EC number: 2.1.1.4
left: N-Acetylserotonin
left: S-Adenosylmethionine
name: N-Acetylserotonin + S-Adenosylmethionine → Melatonin + S-Adenosylhomocysteine
conversion direction: LEFT_TO_RIGHT

2.3.1.87
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000956 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000178 Cytosol/Stoichiometry/1.0
right: Coenzyme A
right: N-Acetylserotonin
spontaneous: false
EC number: 2.3.1.87
left: Serotonin
left: Acetyl-CoA
name: Acetyl-CoA + Serotonin → Coenzyme A + N-Acetylserotonin
conversion direction: LEFT_TO_RIGHT

1.14.13.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002048 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002049 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: 4,6-Dihydroxyquinoline
right: NADP
right: Water
spontaneous: false
EC number: 1.14.13.9
left: Oxygen
left: 5-Hydroxykynurenamine
left: NADPH
name: 5-Hydroxykynurenamine + NADPH + Oxygen → 4,6-Dihydroxyquinoline + NADP + Water
conversion direction: LEFT_TO_RIGHT

4.1.1.28
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002048 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C008092 Cytosol/Stoichiometry/1.0
right: 5-Hydroxykynurenamine
right: Carbon dioxide
spontaneous: false
EC number: 4.1.1.28
left: 5-Hydroxykynurenine
name: 5-Hydroxykynurenine → 5-Hydroxykynurenamine + Carbon dioxide
conversion direction: LEFT_TO_RIGHT

1.13.11.52
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002055 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000358 Cytosol/Stoichiometry/1.0
right: 5-Hydroxy-N-formylkynurenine
spontaneous: false
EC number: 1.13.11.52
left: Oxygen
left: 5-Hydroxy-L-tryptophan
name: 5-Hydroxy-L-tryptophan + Oxygen → 5-Hydroxy-N-formylkynurenine
conversion direction: LEFT_TO_RIGHT

3.5.1.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000092 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002055 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C008092 Cytosol/Stoichiometry/1.0
right: Formic acid
right: 5-Hydroxykynurenine
spontaneous: false
EC number: 3.5.1.9
left: 5-Hydroxy-N-formylkynurenine
left: Water
name: 5-Hydroxy-N-formylkynurenine + Water → 5-Hydroxykynurenine + Formic acid
conversion direction: LEFT_TO_RIGHT

2.1.1.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000749 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000609 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002060 Cytosol/Stoichiometry/1.0
right: 5-Methoxyindoleacetate
right: S-Adenosylhomocysteine
spontaneous: false
EC number: 2.1.1.4
left: 5-Hydroxyindoleacetic acid
left: S-Adenosylmethionine
name: 5-Hydroxyindoleacetic acid + S-Adenosylmethionine → 5-Methoxyindoleacetate + S-Adenosylhomocysteine
conversion direction: LEFT_TO_RIGHT

1.2.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002047 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000609 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytosol/Stoichiometry/1.0
right: 5-Hydroxyindoleacetic acid
right: NADH
spontaneous: false
EC number: 1.2.1.3
left: NAD
left: 5-Hydroxyindoleacetaldehyde
left: Water
name: 5-Hydroxyindoleacetaldehyde + NAD + Water → 5-Hydroxyindoleacetic acid + NADH
conversion direction: LEFT_TO_RIGHT

Phenylalanine-4-hydroxylase
type: ProteinReference
xref: Reference/UniProt A5D9G6
organism: Bos taurus

RNA/43 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: tRNA(Trp)
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16675
type: UnificationXref
id: CHEBI:16675
db: ChEBI

Reference/PubChem-compound 164719
type: UnificationXref
id: 164719
db: PubChem-compound

Reference/BioCyc N-FORMYLKYNURENINE
type: UnificationXref
id: N-FORMYLKYNURENINE
db: BioCyc

1.14.13.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002047 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000178 Cytosol/Stoichiometry/1.0
right: 5-Hydroxyindoleacetaldehyde
right: NADP
right: Water
spontaneous: false
EC number: 1.14.13.9
left: Oxygen
left: Serotonin
left: NADPH
name: NADPH + Oxygen + Serotonin → 5-Hydroxyindoleacetaldehyde + NADP + Water
conversion direction: LEFT_TO_RIGHT

4.1.1.28
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000178 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000358 Cytosol/Stoichiometry/1.0
right: Carbon dioxide
right: Serotonin
spontaneous: false
EC number: 4.1.1.28
left: 5-Hydroxy-L-tryptophan
name: 5-Hydroxy-L-tryptophan → Carbon dioxide + Serotonin
conversion direction: LEFT_TO_RIGHT

1.14.16.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000741 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001541 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000019 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000358 Cytosol/Stoichiometry/1.0
right: 4a-Hydroxytetrahydrobiopterin
right: 5-Hydroxy-L-tryptophan
spontaneous: false
EC number: 1.14.16.4
left: Oxygen
left: L-Tryptophan
left: Tetrahydrobiopterin
name: L-Tryptophan + Oxygen + Tetrahydrobiopterin → 4a-Hydroxytetrahydrobiopterin + 5-Hydroxy-L-tryptophan
conversion direction: LEFT_TO_RIGHT

Compound/PW C001099 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

4.1.1.45
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001026 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000991 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
right: 2-Aminomuconic acid semialdehyde
right: Carbon dioxide
spontaneous: false
EC number: 4.1.1.45
left: 2-Amino-3-carboxymuconic acid semialdehyde
name: 2-Amino-3-carboxymuconic acid semialdehyde → 2-Aminomuconic acid semialdehyde + Carbon dioxide
conversion direction: LEFT_TO_RIGHT

Tryptamine
type: SmallMolecule
cellular location: Cytosol
entity reference: Tryptamine

1.13.11.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001026 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001137 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
right: 2-Amino-3-carboxymuconic acid semialdehyde
spontaneous: false
EC number: 1.13.11.6
left: Oxygen
left: 3-Hydroxyanthranilic acid
name: 3-Hydroxyanthranilic acid + Oxygen → 2-Amino-3-carboxymuconic acid semialdehyde
conversion direction: LEFT_TO_RIGHT

Reaction146434
type: BiochemicalReaction
participant stoichiometry: Compound/PW C007219 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002053 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytosol/Stoichiometry/1.0
right: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid
right: L-Glutamic acid
spontaneous: false
left: L-3-Hydroxykynurenine
left: Oxoglutaric acid
name: L-3-Hydroxykynurenine + Oxoglutaric acid → 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid + L-Glutamic acid
conversion direction: LEFT_TO_RIGHT

1.11.1.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001137 Cytosol/Stoichiometry/2.0
participant stoichiometry: Compound/PW C002050 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/2.0
right: Cinnavalininate
right: Water
spontaneous: false
EC number: 1.11.1.6
left: Oxygen
left: 3-Hydroxyanthranilic acid
name: 2 3-Hydroxyanthranilic acid + Oxygen → Cinnavalininate + 2 Water
conversion direction: LEFT_TO_RIGHT

3.7.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C007219 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001137 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000105 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: L-Alanine
right: 3-Hydroxyanthranilic acid
spontaneous: false
EC number: 3.7.1.3
left: L-3-Hydroxykynurenine
left: Water
name: L-3-Hydroxykynurenine + Water → 3-Hydroxyanthranilic acid + L-Alanine
conversion direction: LEFT_TO_RIGHT

1.14.13.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000538 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007219 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: L-3-Hydroxykynurenine
right: NADP
right: Water
spontaneous: false
EC number: 1.14.13.9
left: Oxygen
left: L-Kynurenine
left: NADPH
name: L-Kynurenine + NADPH + Oxygen → L-3-Hydroxykynurenine + NADP + Water
conversion direction: LEFT_TO_RIGHT

Reference/UniProt A5D9G6
type: UnificationXref
id: A5D9G6
db: UniProt

Reaction146430
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000538 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000778 Cytosol/Stoichiometry/1.0
right: 4-(2-Aminophenyl)-2,4-dioxobutanoic acid
right: L-Glutamic acid
spontaneous: false
left: Oxoglutaric acid
left: L-Kynurenine
name: L-Kynurenine + Oxoglutaric acid → 4-(2-Aminophenyl)-2,4-dioxobutanoic acid + L-Glutamic acid
conversion direction: LEFT_TO_RIGHT

Reference/CAS 3342-77-6
type: UnificationXref
id: 3342-77-6
db: CAS

Reference/PubChem-compound 5280625
type: UnificationXref
id: 5280625
db: PubChem-compound

Kynureninase
type: Protein
cellular location: Cytosol
entity reference: Kynureninase

ChemicalStructure/PW C000877
type: ChemicalStructure
structure format: SMILES
structure data: NC1=CC=CC=C1C(O)=O

Reference/ChemSpider 5497
type: UnificationXref
id: 5497
db: ChemSpider

Reference/ChemSpider 5013
type: UnificationXref
id: 5013
db: ChemSpider

Reference/KEGG Compound C00780
type: UnificationXref
id: C00780
db: KEGG Compound

Reference/ChEBI CHEBI 16680
type: UnificationXref
id: CHEBI:16680
db: ChEBI

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

3.7.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000538 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000105 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000877 Cytosol/Stoichiometry/1.0
right: 2-Aminobenzoic acid
right: L-Alanine
spontaneous: false
EC number: 3.7.1.3
left: L-Kynurenine
left: Water
name: L-Kynurenine + Water → 2-Aminobenzoic acid + L-Alanine
conversion direction: LEFT_TO_RIGHT

3.5.1.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000092 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002057 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000877 Cytosol/Stoichiometry/1.0
right: Formic acid
right: 2-Aminobenzoic acid
spontaneous: false
EC number: 3.5.1.9
left: Formylanthranilic acid
left: Water
name: Formylanthranilic acid + Water → 2-Aminobenzoic acid + Formic acid
conversion direction: LEFT_TO_RIGHT

3.5.1.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000092 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000538 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000935 Cytosol/Stoichiometry/1.0
right: Formic acid
right: L-Kynurenine
spontaneous: false
EC number: 3.5.1.9
left: N'-Formylkynurenine
left: Water
name: N'-Formylkynurenine + Water → Formic acid + L-Kynurenine
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0000763
type: UnificationXref
id: HMDB0000763
db: HMDB

3.7.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000105 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002057 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000935 Cytosol/Stoichiometry/1.0
right: Formylanthranilic acid
right: L-Alanine
spontaneous: false
EC number: 3.7.1.3
left: N'-Formylkynurenine
left: Water
name: N'-Formylkynurenine + Water → Formylanthranilic acid + L-Alanine
conversion direction: LEFT_TO_RIGHT

1.13.11.11
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000741 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000935 Cytosol/Stoichiometry/1.0
right: N'-Formylkynurenine
spontaneous: false
EC number: 1.13.11.11
left: Oxygen
left: L-Tryptophan
name: L-Tryptophan + Oxygen → N'-Formylkynurenine
conversion direction: LEFT_TO_RIGHT

Kynurenine formamidase
type: Protein
cellular location: Cytosol
entity reference: Kynurenine formamidase

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

L-Tryptophyl-tRNA(Trp)
type: Rna
cellular location: Cytoplasm
entity reference: L-Tryptophyl-tRNA(Trp)

Aromatic-L-amino-acid decarboxylase
type: Protein
cellular location: Cytosol
entity reference: Aromatic-L-amino-acid decarboxylase

Xanthurenic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000881
xref: Reference/KEGG Compound C02470
xref: Reference/ChEBI CHEBI 217069
xref: Reference/CAS 59-00-7
xref: Reference/BioCyc XANTHURENATE
xref: Reference/ChemSpider 5497
xref: Reference/PubChem-compound 5699
chemical formula: C10H7NO4
molecular weight: 205.0375
structure: ChemicalStructure/PW C000703

Reference/CAS 61-54-1
type: UnificationXref
id: 61-54-1
db: CAS

Reference/CAS 7722-84-1
type: UnificationXref
id: 7722-84-1
db: CAS

Reference/KEGG Compound C03824
type: UnificationXref
id: C03824
db: KEGG Compound

Reference/PubChem-compound 802
type: UnificationXref
id: 802
db: PubChem-compound

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

Reference/PubChem-compound 800
type: UnificationXref
id: 800
db: PubChem-compound

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/PubChem-compound 439280
type: UnificationXref
id: 439280
db: PubChem-compound

Reference/PubChem-compound 114918
type: UnificationXref
id: 114918
db: PubChem-compound

Reference/HMDB HMDB0003125
type: UnificationXref
id: HMDB0003125
db: HMDB

Reference/HMDB HMDB0001185
type: UnificationXref
id: HMDB0001185
db: HMDB

Compound/PW C000019 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tetrahydrobiopterin
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00328
type: UnificationXref
id: C00328
db: KEGG Compound

Reference/UniProt F1N7C5
type: UnificationXref
id: F1N7C5
db: UniProt

N-Acetylserotonin
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17697
xref: Reference/HMDB HMDB0001238
xref: Reference/KEGG Compound C00978
xref: Reference/CAS 1210-83-9
xref: Reference/PubChem-compound 903
xref: Reference/ChemSpider 879
xref: Reference/BioCyc N-ACETYL-SEROTONIN
chemical formula: C12H14N2O2
molecular weight: 218.10553
structure: ChemicalStructure/PW C000956

Reference/HMDB HMDB0001190
type: UnificationXref
id: HMDB0001190
db: HMDB

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/HMDB HMDB0002281
type: UnificationXref
id: HMDB0002281
db: HMDB

Reference/ChemSpider 17924
type: UnificationXref
id: 17924
db: ChemSpider

Compound/PW C008092 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Hydroxykynurenine
stoichiometric coefficient: 1.0

S-Adenosylmethionine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24762165
xref: Reference/KEGG Compound C00019
xref: Reference/ChemSpider 31983
xref: Reference/ChEBI CHEBI 15414
xref: Reference/CAS 485-80-3
xref: Reference/BioCyc S-ADENOSYLMETHIONINE
xref: Reference/HMDB HMDB0001185
chemical formula: C15H23N6O5S
molecular weight: 399.14505
structure: ChemicalStructure/PW C000921

ReactionCatalysis168856
type: Catalysis
controller: Tryptophan--tRNA ligase, mitochondrial
controlled: Reaction178775
control type: ACTIVATION

ReactionCatalysis168855
type: Catalysis
controller: Tryptophan--tRNA ligase, cytoplasmic
controlled: Reaction178775
control type: ACTIVATION

Tryptophan Metabolism
type: Pathway
pathway order: PathwayEnzymeReaction/2112862
pathway order: PathwaySubPathway/108293
pathway order: PathwayEnzymeReaction/2112841
pathway order: PathwayEnzymeReaction/2112863
pathway order: PathwayEnzymeReaction/2112860
pathway order: PathwayEnzymeReaction/2112861
pathway order: PathwayEnzymeReaction/2112844
pathway order: PathwayEnzymeReaction/2112866
pathway order: PathwayEnzymeReaction/2112845
pathway order: PathwayEnzymeReaction/2112867
pathway order: PathwayEnzymeReaction/2112842
pathway order: PathwayEnzymeReaction/2112864
pathway order: PathwayEnzymeReaction/2112843
pathway order: PathwayEnzymeReaction/2112865
pathway order: PathwayEnzymeReaction/2112848
pathway order: PathwayEnzymeReaction/2112849
pathway order: PathwayEnzymeReaction/2112846
pathway order: PathwayEnzymeReaction/2112868
pathway order: PathwayEnzymeReaction/2112847
pathway order: PathwayEnzymeReaction/2112869
pathway order: PathwayEnzymeReaction/2112870
pathway order: PathwayEnzymeReaction/2112851
pathway order: PathwayEnzymeReaction/2112873
pathway order: PathwayTransport/2112879
pathway order: PathwayEnzymeReaction/2112852
pathway order: PathwayEnzymeReaction/2112874
pathway order: PathwayEnzymeReaction/2112871
pathway order: PathwayEnzymeReaction/2112850
pathway order: PathwayEnzymeReaction/2112872
pathway order: PathwayEnzymeReaction/2112855
pathway order: PathwayEnzymeReaction/2112877
pathway order: PathwayEnzymeReaction/2112856
pathway order: PathwayEnzymeReaction/2112878
pathway order: PathwayEnzymeReaction/2112853
pathway order: PathwayEnzymeReaction/2112875
pathway order: PathwayEnzymeReaction/2112854
pathway order: PathwayEnzymeReaction/2112876
pathway order: PathwayEnzymeReaction/2112859
pathway order: PathwayEnzymeReaction/2112857
pathway order: PathwayEnzymeReaction/2112858
pathway component: Reaction178775
pathway component: ReactionCatalysis136600
pathway component: Reaction1615
pathway component: ReactionCatalysis136605
pathway component: ReactionCatalysis136606
pathway component: ReactionCatalysis136607
pathway component: ReactionCatalysis136608
pathway component: ReactionCatalysis136601
pathway component: ReactionCatalysis136602
pathway component: ReactionCatalysis136603
pathway component: ReactionCatalysis136604
pathway component: 1.13.11.52
pathway component: Reaction146456
pathway component: Reaction146455
pathway component: 1.2.1.3
pathway component: 1.14.13.9
pathway component: 4.1.1.28
pathway component: Reaction146450
pathway component: ReactionCatalysis136577
pathway component: ReactionCatalysis136578
pathway component: ReactionCatalysis136579
pathway component: 1.14.14.1
pathway component: 2.1.1.4
pathway component: ReactionCatalysis136609
pathway component: 2.3.1.87
pathway component: 3.5.1.9
pathway component: Nicotinate and Nicotinamide Metabolism
pathway component: ReactionCatalysis136586
pathway component: ReactionCatalysis136587
pathway component: ReactionCatalysis136588
pathway component: ReactionCatalysis136589
pathway component: ReactionCatalysis136582

Compound/PW C000921 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylmethionine
stoichiometric coefficient: 1.0

Reference/ChemSpider 5863
type: UnificationXref
id: 5863
db: ChemSpider

Reference/ChEBI CHEBI 17442
type: UnificationXref
id: CHEBI:17442
db: ChEBI

Indoleacetaldehyde
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001190
xref: Reference/KEGG Compound C00637
xref: Reference/PubChem-compound 800
xref: Reference/CAS 2591-98-2
xref: Reference/ChEBI CHEBI 18086
xref: Reference/ChemSpider 778
xref: Reference/BioCyc INDOLE ACETALDEHYDE
chemical formula: C10H9NO
molecular weight: 159.06842
structure: ChemicalStructure/PW C000926

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Compound/PW C000092 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Formic acid
stoichiometric coefficient: 1.0

ChemicalStructure/PW C002055
type: ChemicalStructure
structure format: SMILES
structure data: NC(CC(=O)C1=C(NC=O)C=CC(O)=C1)C(O)=O

ChemicalStructure/PW C002057
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C1=CC=CC=C1NC=O

ChemicalStructure/PW C002050
type: ChemicalStructure
structure format: SMILES

5-Hydroxykynurenine
type: SmallMolecule
cellular location: Cytosol
entity reference: 5-Hydroxykynurenine

ChemicalStructure/PW C002052
type: ChemicalStructure
structure format: SMILES
structure data: COC1=C(O)C=C2NC=C(CCNC(C)=O)C2=C1

ChemicalStructure/PW C002053
type: ChemicalStructure
structure format: SMILES
structure data: NC1=C(C=CC=C1O)C(=O)CC(=O)C(O)=O

N'-Formylkynurenine
type: SmallMoleculeReference
xref: Reference/ChemSpider 886
xref: Reference/HMDB HMDB0001200
xref: Reference/KEGG Compound C02406
xref: Reference/PubChem-compound 910
xref: Reference/ChEBI CHEBI 18377
xref: Reference/BioCyc N-FORMYLKYNURENINE
xref: Reference/CAS 1022-31-7
chemical formula: C11H12N2O4
molecular weight: 236.07971
structure: ChemicalStructure/PW C000935

Reference/KEGG Compound C00108
type: UnificationXref
id: C00108
db: KEGG Compound

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

Reference/ChEBI CHEBI 17697
type: UnificationXref
id: CHEBI:17697
db: ChEBI

Adenosine monophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine monophosphate

Reference/CAS 1134-01-6
type: UnificationXref
id: 1134-01-6
db: CAS

Compound/PW C001137 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: 3-Hydroxyanthranilic acid
stoichiometric coefficient: 2.0

Reference/CAS 73-22-3
type: UnificationXref
id: 73-22-3
db: CAS

Reference/PubChem-compound 1826
type: UnificationXref
id: 1826
db: PubChem-compound

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

ChemicalStructure/PW C002060
type: ChemicalStructure
structure format: SMILES
structure data: COC1=CC2=C(NC=C2CC(O)=O)C=C1

ChemicalStructure/PW C000926
type: ChemicalStructure
structure format: SMILES
structure data: O=CCC1=CNC2=C1C=CC=C2

Compound/PW C000146 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

L-Tryptophan
type: SmallMoleculeReference
xref: Reference/CAS 73-22-3
xref: Reference/KEGG Compound C00078
xref: Reference/ChEBI CHEBI 16828
xref: Reference/PubChem-compound 6305
xref: Reference/BioCyc TRP
xref: Reference/HMDB HMDB0000929
xref: Reference/ChemSpider 6066
chemical formula: C11H12N2O2
molecular weight: 204.08987
structure: ChemicalStructure/PW C000741

ChemicalStructure/PW C000921
type: ChemicalStructure
structure format: SMILES

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Phenylalanine-4-hydroxylase
type: Protein
cellular location: Cytosol
entity reference: Phenylalanine-4-hydroxylase

S-Adenosylhomocysteine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 25246222
xref: Reference/ChemSpider 388301
xref: Reference/BioCyc ADENOSYL-HOMO-CYS
xref: Reference/CAS 979-92-0
xref: Reference/KEGG Compound C00021
xref: Reference/ChEBI CHEBI 16680
xref: Reference/HMDB HMDB0000939
chemical formula: C14H20N6O5S
molecular weight: 384.12158
structure: ChemicalStructure/PW C000749

Reference/HMDB HMDB0004259
type: UnificationXref
id: HMDB0004259
db: HMDB

2-Aminomuconic acid semialdehyde
type: SmallMoleculeReference
xref: Reference/ChemSpider 4444230
xref: Reference/KEGG Compound C03824
xref: Reference/BioCyc 2-AMINOMUCONATE SEMIALDEHYDE
xref: Reference/ChEBI CHEBI 15745
xref: Reference/CAS 245128-91-0
xref: Reference/HMDB HMDB0001280
xref: Reference/PubChem-compound 5280625
chemical formula: C6H7NO3
molecular weight: 141.04259
structure: ChemicalStructure/PW C000991

2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
type: Protein
cellular location: Cytosol
entity reference: 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase

Reference/ChemSpider 1037
type: UnificationXref
id: 1037
db: ChemSpider

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

ChemicalStructure/PW C000935
type: ChemicalStructure
structure format: SMILES
structure data: NC(CC(=O)C1=CC=CC=C1NC=O)C(O)=O

Compound/PW C000956 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Acetylserotonin
stoichiometric coefficient: 1.0

Tetrahydrobiopterin
type: SmallMolecule
cellular location: Cytosol
entity reference: Tetrahydrobiopterin

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Reference/ChemSpider 102864
type: UnificationXref
id: 102864
db: ChemSpider

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine triphosphate

Reference/UniProt P10938
type: UnificationXref
id: P10938
db: UniProt

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Indoleacetaldehyde
type: SmallMolecule
cellular location: Cytosol
entity reference: Indoleacetaldehyde

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/BioCyc QUINOLINATE
type: UnificationXref
id: QUINOLINATE
db: BioCyc

Reference/PubChem-compound 74688
type: UnificationXref
id: 74688
db: PubChem-compound

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Reference/ChemSpider 388301
type: UnificationXref
id: 388301
db: ChemSpider

Protein/15362 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Aldehyde dehydrogenase, mitochondrial
stoichiometric coefficient: 4.0

Reference/ChEBI CHEBI 18344
type: UnificationXref
id: CHEBI:18344
db: ChEBI

Reference/ChEBI CHEBI 28136
type: UnificationXref
id: CHEBI:28136
db: ChEBI

Tryptophan--tRNA ligase, cytoplasmic
type: Complex
component stoichiometry: Protein/16583 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Tryptophan--tRNA ligase, cytoplasmic

Reference/ChemSpider 778
type: UnificationXref
id: 778
db: ChemSpider

Compound/PW C000741 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Tryptophan
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00398
type: UnificationXref
id: C00398
db: KEGG Compound

Reference/CAS 328-50-7
type: UnificationXref
id: 328-50-7
db: CAS

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

Reference/HMDB HMDB0000259
type: UnificationXref
id: HMDB0000259
db: HMDB

Reference/BioCyc HYDROGEN-PEROXIDE
type: UnificationXref
id: HYDROGEN-PEROXIDE
db: BioCyc

Reference/ChemSpider 389609
type: UnificationXref
id: 389609
db: ChemSpider

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

Reference/ChemSpider 389612
type: UnificationXref
id: 389612
db: ChemSpider

Reference/ChemSpider 389616
type: UnificationXref
id: 389616
db: ChemSpider

Reference/ChemSpider 389615
type: UnificationXref
id: 389615
db: ChemSpider

Reference/ChemSpider 389614
type: UnificationXref
id: 389614
db: ChemSpider

Reference/KEGG Compound C01252
type: UnificationXref
id: C01252
db: KEGG Compound

Compound/PW C000207 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tryptamine
stoichiometric coefficient: 1.0

Reference/ChemSpider 763
type: UnificationXref
id: 763
db: ChemSpider

Reference/HMDB HMDB0000027
type: UnificationXref
id: HMDB0000027
db: HMDB

Compound/PW C000156 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Quinolinic acid
stoichiometric coefficient: 1.0

3-Hydroxyanthranilic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: 3-Hydroxyanthranilic acid

Reference/BioCyc TRP
type: UnificationXref
id: TRP
db: BioCyc

Reference/ChEBI CHEBI 217069
type: UnificationXref
id: CHEBI:217069
db: ChEBI

Reference/BioCyc CPD-476
type: UnificationXref
id: CPD-476
db: BioCyc

Reference/UniProt Q3MHE7
type: UnificationXref
id: Q3MHE7
db: UniProt

Reference/ChEBI CHEBI 18377
type: UnificationXref
id: CHEBI:18377
db: ChEBI

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

Reference/HMDB HMDB0001123
type: UnificationXref
id: HMDB0001123
db: HMDB

Protein/16583 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Tryptophan--tRNA ligase, cytoplasmic
stoichiometric coefficient: 2.0

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

N-Acetylserotonin
type: SmallMolecule
cellular location: Cytosol
entity reference: N-Acetylserotonin

Reference/PubChem-compound 896
type: UnificationXref
id: 896
db: PubChem-compound

Indoleacetic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Indoleacetic acid

L-Kynurenine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000684
xref: Reference/KEGG Compound C00328
xref: Reference/ChemSpider 141580
xref: Reference/ChEBI CHEBI 16946
xref: Reference/PubChem-compound 161166
xref: Reference/CAS 2922-83-0
xref: Reference/BioCyc L-KYNURENINE
chemical formula: C10H12N2O3
molecular weight: 208.0848
structure: ChemicalStructure/PW C000538

NAD
type: SmallMolecule
cellular location: Cytosol
entity reference: NAD

4-(2-Aminophenyl)-2,4-dioxobutanoic acid
type: SmallMoleculeReference
xref: Reference/BioCyc CPD-476
xref: Reference/HMDB HMDB0000978
xref: Reference/KEGG Compound C01252
xref: Reference/ChEBI CHEBI 17442
xref: Reference/PubChem-compound 472
xref: Reference/ChemSpider 459
chemical formula: C10H9NO4
molecular weight: 207.05316
structure: ChemicalStructure/PW C000778

Reference/KEGG Compound C05639
type: UnificationXref
id: C05639
db: KEGG Compound

Reference/KEGG Compound C05638
type: UnificationXref
id: C05638
db: KEGG Compound

Reference/KEGG Compound C05635
type: UnificationXref
id: C05635
db: KEGG Compound

Reference/KEGG Compound C05634
type: UnificationXref
id: C05634
db: KEGG Compound

Reference/UniProt F1MCH2
type: UnificationXref
id: F1MCH2
db: UniProt

N-Methylserotonin
type: SmallMolecule
cellular location: Cytosol
entity reference: N-Methylserotonin

Reference/CAS 606-14-4
type: UnificationXref
id: 606-14-4
db: CAS

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

S-Adenosylhomocysteine
type: SmallMolecule
cellular location: Cytosol
entity reference: S-Adenosylhomocysteine

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

Reference/KEGG Compound C05640
type: UnificationXref
id: C05640
db: KEGG Compound

Reference/PubChem-compound 3845
type: UnificationXref
id: 3845
db: PubChem-compound

ChemicalStructure/PW C001137
type: ChemicalStructure
structure format: SMILES
structure data: NC1=C(O)C=CC=C1C(O)=O

Reference/UniProt Q1LZC6
type: UnificationXref
id: Q1LZC6
db: UniProt

Reference/ChemSpider 780
type: UnificationXref
id: 780
db: ChemSpider

Reference/CAS 245128-91-0
type: UnificationXref
id: 245128-91-0
db: CAS

ReactionCatalysis136600
type: Catalysis
controller: Cytochrome P450 2U1
controlled: 1.14.14.1
control type: ACTIVATION

L-Alanine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00041
xref: Reference/ChemSpider 5735
xref: Reference/ChEBI CHEBI 16977
xref: Reference/BioCyc L-ALPHA-ALANINE
xref: Reference/HMDB HMDB0000161
xref: Reference/CAS 56-41-7
xref: Reference/PubChem-compound 5950
chemical formula: C3H7NO2
molecular weight: 89.047676
structure: ChemicalStructure/PW C000105

Protein/Generic38 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxidized flavoprotein
stoichiometric coefficient: 1.0

ReactionCatalysis136605
type: Catalysis
controller: Kynurenine 3-monooxygenase
controlled: 1.14.13.9
control type: ACTIVATION

Reference/KEGG Compound C05645
type: UnificationXref
id: C05645
db: KEGG Compound

ReactionCatalysis136606
type: Catalysis
controller: Aldehyde dehydrogenase, mitochondrial
controlled: 1.2.1.3
control type: ACTIVATION

Reference/KEGG Compound C03227
type: UnificationXref
id: C03227
db: KEGG Compound

Reference/KEGG Compound C05648
type: UnificationXref
id: C05648
db: KEGG Compound

ReactionCatalysis136607
type: Catalysis
controller: Phenylethanolamine N-methyltransferase
controlled: Reaction146455
control type: ACTIVATION

Serotonin
type: SmallMolecule
cellular location: Cytosol
entity reference: Serotonin

Reference/KEGG Compound C05647
type: UnificationXref
id: C05647
db: KEGG Compound

ReactionCatalysis136608
type: Catalysis
controller: Aldehyde oxidase 1
controlled: Reaction146456
control type: ACTIVATION

Hydrogen peroxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen peroxide

ReactionCatalysis136601
type: Catalysis
controller: Indoleamine 2,3-dioxygenase 1
controlled: 1.13.11.52
control type: ACTIVATION

Reference/KEGG Compound C05642
type: UnificationXref
id: C05642
db: KEGG Compound

ReactionCatalysis136602
type: Catalysis
controller: Phenylethanolamine N-methyltransferase
controlled: Reaction146450
control type: ACTIVATION

Reduced flavoprotein
type: ProteinReference
xref: Reference/ChEBI CHEBI 5086
organism: Bos taurus

ReactionCatalysis136603
type: Catalysis
controller: Indoleamine 2,3-dioxygenase 1
controlled: 1.13.11.52
control type: ACTIVATION

Reference/KEGG Compound C05643
type: UnificationXref
id: C05643
db: KEGG Compound

Oxidized flavoprotein
type: ProteinReference
xref: Reference/ChEBI CHEBI 5086
organism: Bos taurus

ReactionCatalysis136604
type: Catalysis
controller: Aromatic-L-amino-acid decarboxylase
controlled: 4.1.1.28
control type: ACTIVATION

Reference/KEGG Compound C05651
type: UnificationXref
id: C05651
db: KEGG Compound

Reference/HMDB HMDB0001389
type: UnificationXref
id: HMDB0001389
db: HMDB

Tryptophan--tRNA ligase, cytoplasmic
type: ProteinReference
xref: Reference/UniProt Q3SZK9
organism: Bos taurus

Tryptophan--tRNA ligase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q3T099
organism: Bos taurus

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Reference/CAS 2922-83-0
type: UnificationXref
id: 2922-83-0
db: CAS

ChemicalStructure/PW C000092
type: ChemicalStructure
structure format: SMILES
structure data: OC=O

5-Hydroxy-L-tryptophan
type: SmallMoleculeReference
xref: Reference/ChemSpider 388413
xref: Reference/CAS 4350-09-8
xref: Reference/BioCyc 5-HYDROXY-TRYPTOPHAN
xref: Reference/ChEBI CHEBI 17780
xref: Reference/KEGG Compound C00643
xref: Reference/PubChem-compound 439280
xref: Reference/HMDB HMDB0000472
chemical formula: C11H12N2O3
molecular weight: 220.0848
structure: ChemicalStructure/PW C000358

Reference/ChemSpider 132989
type: UnificationXref
id: 132989
db: ChemSpider

Reference/CAS 2208-41-5
type: UnificationXref
id: 2208-41-5
db: CAS

Reference/KEGG Compound C05653
type: UnificationXref
id: C05653
db: KEGG Compound

ChemicalStructure/PW C002047
type: ChemicalStructure
structure format: SMILES
structure data: OC1=CC2=C(NC=C2CC=O)C=C1

Reference/KEGG Compound C05660
type: UnificationXref
id: C05660
db: KEGG Compound

ChemicalStructure/PW C002048
type: ChemicalStructure
structure format: SMILES
structure data: NCCC(=O)C1=C(N)C=CC(O)=C1

ChemicalStructure/PW C002049
type: ChemicalStructure
structure format: SMILES
structure data: OC1=CC2=C(O)C=CN=C2C=C1

ReactionCatalysis136609
type: Catalysis
controller: Indoleamine 2,3-dioxygenase 1
controlled: 1.13.11.52
control type: ACTIVATION

Tryptophan 2,3-dioxygenase
type: ProteinReference
xref: Reference/UniProt Q2KIQ5
organism: Bos taurus

Kynureninase
type: ProteinReference
xref: Reference/UniProt F1MCH2
organism: Bos taurus

Reference/PubChem-compound 6088
type: UnificationXref
id: 6088
db: PubChem-compound

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

Kynurenic acid
type: SmallMoleculeReference
xref: Reference/ChemSpider 3712
xref: Reference/PubChem-compound 3845
xref: Reference/KEGG Compound C01717
xref: Reference/HMDB HMDB0000715
xref: Reference/CAS 492-27-3
xref: Reference/ChEBI CHEBI 18344
chemical formula: C10H7NO3
molecular weight: 189.04259
structure: ChemicalStructure/PW C000566

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

Reference/CAS 73-31-4
type: UnificationXref
id: 73-31-4
db: CAS

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Reference/PubChem-compound 25246222
type: UnificationXref
id: 25246222
db: PubChem-compound

Reference/ChEBI CHEBI 2076
type: UnificationXref
id: CHEBI:2076
db: ChEBI

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Compound/PW C000778 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-(2-Aminophenyl)-2,4-dioxobutanoic acid
stoichiometric coefficient: 1.0

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Formylanthranilic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Formylanthranilic acid

Compound/PW C001316 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Tryptophan--tRNA ligase, mitochondrial
type: Protein
cellular location: Cytoplasm
entity reference: Tryptophan--tRNA ligase, mitochondrial

Protein/15517 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Catalase
stoichiometric coefficient: 4.0

5-Hydroxy-L-tryptophan
type: SmallMolecule
cellular location: Cytosol
entity reference: 5-Hydroxy-L-tryptophan

Reference/PubChem-compound 1864
type: UnificationXref
id: 1864
db: PubChem-compound

Reference/CAS 118-92-3
type: UnificationXref
id: 118-92-3
db: CAS

Reference/INSDC 948275
type: UnificationXref
id: 948275
db: INSDC

ChemicalStructure/PW C000566
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C1=CC(=O)C2=CC=CC=C2N1

Compound/PW C000749 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylhomocysteine
stoichiometric coefficient: 1.0

Compound/PW C008135 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Formyl-5-hydroxykynurenamine
stoichiometric coefficient: 1.0

Compound/PW C002132 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Methylserotonin
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Quinolinic acid
type: SmallMoleculeReference
xref: Reference/CAS 89-00-9
xref: Reference/ChEBI CHEBI 16675
xref: Reference/HMDB HMDB0000232
xref: Reference/ChemSpider 1037
xref: Reference/BioCyc QUINOLINATE
xref: Reference/KEGG Compound C03722
xref: Reference/PubChem-compound 1066
chemical formula: C7H5NO4
molecular weight: 167.02185
structure: ChemicalStructure/PW C000156

Acetyl-CoA
type: SmallMolecule
cellular location: Cytosol
entity reference: Acetyl-CoA

Compound/PW C000877 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Aminobenzoic acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 4444266
type: UnificationXref
id: 4444266
db: ChemSpider

Reference/PubChem-compound 171161
type: UnificationXref
id: 171161
db: PubChem-compound

N-Methyltryptamine
type: SmallMolecule
cellular location: Cytosol
entity reference: N-Methyltryptamine

Compound/PW C000143 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Reference/PubChem-compound 472
type: UnificationXref
id: 472
db: PubChem-compound

Reference/ChEBI CHEBI 27823
type: UnificationXref
id: CHEBI:27823
db: ChEBI

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/ChemSpider 91624
type: UnificationXref
id: 91624
db: ChemSpider

Nicotinate and Nicotinamide Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108293
pathway component: SubPathwayInteraction108293
xref: Reference/SMPDB SMP0000048
xref: Reference/PathWhiz PW000151
name: SubPathway

Kynurenine 3-monooxygenase
type: Protein
cellular location: Cytosol
entity reference: Kynurenine 3-monooxygenase

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Indoleacetic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 16411
xref: Reference/CAS 87-51-4
xref: Reference/KEGG Compound C00954
xref: Reference/PubChem-compound 802
xref: Reference/ChemSpider 780
xref: Reference/HMDB HMDB0000197
chemical formula: C10H9NO2
molecular weight: 175.06332
structure: ChemicalStructure/PW C000128

5-Hydroxykynurenine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C05651
xref: Reference/ChEBI CHEBI 2076
xref: Reference/ChemSpider 389616
xref: Reference/CAS 720-00-3
xref: Reference/PubChem-compound 440745
xref: Reference/HMDB HMDB0012819
chemical formula: C10H12N2O4
molecular weight: 224.07971
structure: ChemicalStructure/PW C008092

Aromatic-L-amino-acid decarboxylase
type: ProteinReference
xref: Reference/UniProt Q0V8S3
organism: Bos taurus

2-Amino-3-carboxymuconic acid semialdehyde
type: SmallMolecule
cellular location: Cytosol
entity reference: 2-Amino-3-carboxymuconic acid semialdehyde

Compound/PW C002055 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Hydroxy-N-formylkynurenine
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Oxoglutaric acid
type: SmallMoleculeReference
xref: Reference/CAS 328-50-7
xref: Reference/PubChem-compound 51
xref: Reference/BioCyc 2-KETOGLUTARATE
xref: Reference/HMDB HMDB0000208
xref: Reference/ChEBI CHEBI 30915
xref: Reference/KEGG Compound C00026
xref: Reference/ChemSpider 50
chemical formula: C5H6O5
molecular weight: 146.02153
structure: ChemicalStructure/PW C000134

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Reference/BioCyc BUFOTENINE
type: UnificationXref
id: BUFOTENINE
db: BioCyc

Reference/CAS 50-67-9
type: UnificationXref
id: 50-67-9
db: CAS

Reference/BioCyc ADENOSYL-HOMO-CYS
type: UnificationXref
id: ADENOSYL-HOMO-CYS
db: BioCyc

Phenylethanolamine N-methyltransferase
type: ProteinReference
xref: Reference/UniProt P10938
organism: Bos taurus

Reference/HMDB HMDB0000684
type: UnificationXref
id: HMDB0000684
db: HMDB

5-Methoxyindoleacetate
type: SmallMolecule
cellular location: Cytosol
entity reference: 5-Methoxyindoleacetate

Aldehyde oxidase 1
type: Protein
cellular location: Cytosol
entity reference: Aldehyde oxidase 1

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

ChemicalStructure/PW C008092
type: ChemicalStructure
structure format: SMILES
structure data: NC(CC(=O)C1=C(N)C=CC(O)=C1)C(O)=O

Compound/PW C002133 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Methyltryptamine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16977
type: UnificationXref
id: CHEBI:16977
db: ChEBI

Reference/HMDB HMDB0000208
type: UnificationXref
id: HMDB0000208
db: HMDB

Reference/BioCyc 3-HYDROXY-ANTHRANILATE
type: UnificationXref
id: 3-HYDROXY-ANTHRANILATE
db: BioCyc

ChemicalStructure/PW C000128
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC1=CNC2=C1C=CC=C2

Reference/PubChem-compound 11811
type: UnificationXref
id: 11811
db: PubChem-compound

Compound/PW C000741 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Tryptophan
stoichiometric coefficient: 1.0

N-Methylserotonin
type: SmallMoleculeReference
xref: Reference/KEGG Compound C06212
xref: Reference/HMDB HMDB0004369
xref: Reference/ChEBI CHEBI 48294
xref: Reference/ChemSpider 132989
xref: Reference/PubChem-compound 150885
xref: Reference/CAS 1134-01-6
chemical formula: C11H14N2O
molecular weight: 190.11061
structure: ChemicalStructure/PW C002132

N-Methyltryptamine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 28136
xref: Reference/BioCyc BUFOTENINE
xref: Reference/PubChem-compound 6088
xref: Reference/HMDB HMDB0004370
xref: Reference/CAS 61-49-4
xref: Reference/ChemSpider 5863
xref: Reference/KEGG Compound C06213
chemical formula: C11H14N2
molecular weight: 174.11569
structure: ChemicalStructure/PW C002133

ChemicalStructure/PW C000134
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(=O)C(O)=O

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Formyl-5-hydroxykynurenamine
type: SmallMolecule
cellular location: Cytosol
entity reference: Formyl-5-hydroxykynurenamine

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Cytochrome P450 2U1
type: ProteinReference
xref: Reference/UniProt Q0IIF9
organism: Bos taurus

Reference/ChEBI CHEBI 15414
type: UnificationXref
id: CHEBI:15414
db: ChEBI

Compound/PW C000940 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

tRNA(Trp)
type: Rna
cellular location: Cytoplasm
entity reference: tRNA(Trp)

Compound/PW C000721 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 36575
type: UnificationXref
id: CHEBI:36575
db: ChEBI

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 28715
type: UnificationXref
id: CHEBI:28715
db: ChEBI

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

Aldehyde oxidase 1
type: ProteinReference
xref: Reference/UniProt Q3MHE7
organism: Bos taurus

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

5-Hydroxyindoleacetic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: 5-Hydroxyindoleacetic acid

Reference/PubChem-compound 227
type: UnificationXref
id: 227
db: PubChem-compound

Reference/BioCyc S-ADENOSYLMETHIONINE
type: UnificationXref
id: S-ADENOSYLMETHIONINE
db: BioCyc

ChemicalStructure/PW C000105
type: ChemicalStructure
structure format: SMILES
structure data: C[C@H](N)C(O)=O

Reference/CAS 1210-83-9
type: UnificationXref
id: 1210-83-9
db: CAS

Reference/PubChem-compound 161166
type: UnificationXref
id: 161166
db: PubChem-compound

Reference/HMDB HMDB0000232
type: UnificationXref
id: HMDB0000232
db: HMDB

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

Acetyl-N-formyl-5-methoxykynurenamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0004259
xref: Reference/ChemSpider 149637
xref: Reference/CAS 52450-38-1
xref: Reference/PubChem-compound 171161
xref: Reference/KEGG Compound C05642
chemical formula: C13H16N2O4
molecular weight: 264.111
structure: ChemicalStructure/PW C002112

2-Amino-3-carboxymuconic acid semialdehyde
type: SmallMoleculeReference
xref: Reference/ChemSpider 4444266
xref: Reference/PubChem-compound 5280673
xref: Reference/ChEBI CHEBI 995
xref: Reference/KEGG Compound C04409
xref: Reference/CAS 16597-58-3
xref: Reference/BioCyc 2-AMINO-3-CARBOXYMUCONATE SEMIAL
xref: Reference/HMDB HMDB0001330
chemical formula: C7H7NO5
molecular weight: 185.03242
structure: ChemicalStructure/PW C001026

Reference/ChEBI CHEBI 16946
type: UnificationXref
id: CHEBI:16946
db: ChEBI

Reference/BioCyc 5-HYDROXY-TRYPTOPHAN
type: UnificationXref
id: 5-HYDROXY-TRYPTOPHAN
db: BioCyc

Serotonin
type: SmallMoleculeReference
xref: Reference/CAS 50-67-9
xref: Reference/HMDB HMDB0000259
xref: Reference/ChemSpider 5013
xref: Reference/KEGG Compound C00780
xref: Reference/ChEBI CHEBI 28790
xref: Reference/PubChem-compound 5202
chemical formula: C10H12N2O
molecular weight: 176.09496
structure: ChemicalStructure/PW C000178

Reference/CAS 720-00-3
type: UnificationXref
id: 720-00-3
db: CAS

3-hydroxyanthranilate 3,4-dioxygenase
type: ProteinReference
xref: Reference/UniProt Q0VCA8
organism: Bos taurus

3-hydroxyanthranilate 3,4-dioxygenase
type: Protein
cellular location: Cytosol
entity reference: 3-hydroxyanthranilate 3,4-dioxygenase

Reference/HMDB HMDB0000472
type: UnificationXref
id: HMDB0000472
db: HMDB

ChemicalStructure/PW C000358
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CNC2=C1C=C(O)C=C2)C(O)=O

Reference/ChemSpider 6066
type: UnificationXref
id: 6066
db: ChemSpider

SubPathwayInteraction108293
type: Interaction
name: SubPathway108293Reaction
name: SubPathwayReaction
participant: Quinolinic acid

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/CAS 3471-31-6
type: UnificationXref
id: 3471-31-6
db: CAS

Reference/HMDB HMDB0001330
type: UnificationXref
id: HMDB0001330
db: HMDB

Reaction178775
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: RNA/25 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000741 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: RNA/43 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Cytoplasm/Stoichiometry/1.0
right: Adenosine monophosphate
right: L-Tryptophyl-tRNA(Trp)
right: Pyrophosphate
spontaneous: false
left: tRNA(Trp)
left: Adenosine triphosphate
left: L-Tryptophan
name: Adenosine triphosphate + L-Tryptophan + tRNA(Trp) → Adenosine monophosphate + L-Tryptophyl-tRNA(Trp) + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 5699
type: UnificationXref
id: 5699
db: PubChem-compound

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 6305
type: UnificationXref
id: 6305
db: PubChem-compound

Oxidized flavoprotein
type: Protein
cellular location: Cytosol
entity reference: Oxidized flavoprotein

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

Compound/PW C007219 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-3-Hydroxykynurenine
stoichiometric coefficient: 1.0

3,4-Dihydroxyphenylacetaldehyde
type: Complex
component stoichiometry: Protein/16522 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: 3-hydroxyanthranilate 3,4-dioxygenase

Aldehyde dehydrogenase, mitochondrial
type: Protein
cellular location: Cytosol
entity reference: Aldehyde dehydrogenase, mitochondrial

Reference/SMPDB SMP0087237
type: UnificationXref
id: SMP0087237
db: SMPDB

Reference/PubChem-compound 5202
type: UnificationXref
id: 5202
db: PubChem-compound

S-Adenosylmethionine
type: SmallMolecule
cellular location: Cytosol
entity reference: S-Adenosylmethionine

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Bos taurus
type: BioSource
xref: Reference/TAXONOMY 9913

ChemicalStructure/PW C000741
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

Reference/PubChem-compound 18971002
type: UnificationXref
id: 18971002
db: PubChem-compound

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Compound/PW C001541 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4a-Hydroxytetrahydrobiopterin
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

ChemicalStructure/PW C000703
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C1=NC2=C(O)C=CC=C2C(O)=C1

Reference/CAS 89-00-9
type: UnificationXref
id: 89-00-9
db: CAS

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Reference/ChEBI CHEBI 308079
type: UnificationXref
id: CHEBI:308079
db: ChEBI

Reference/ChEBI CHEBI 16765
type: UnificationXref
id: CHEBI:16765
db: ChEBI

Reference/KEGG Compound C01717
type: UnificationXref
id: C01717
db: KEGG Compound

Compound/PW C000095 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Reference/PubChem-compound 129803
type: UnificationXref
id: 129803
db: PubChem-compound

ChemicalStructure/PW C000956
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)NCCC1=CNC2=C1C=C(O)C=C2

Melatonin
type: SmallMoleculeReference
xref: Reference/CAS 73-31-4
xref: Reference/PubChem-compound 896
xref: Reference/ChEBI CHEBI 16796
xref: Reference/HMDB HMDB0001389
xref: Reference/ChemSpider 872
xref: Reference/BioCyc N-ACETYL-5-METHOXY-TRYPTAMINE
xref: Reference/KEGG Compound C01598
chemical formula: C13H16N2O2
molecular weight: 232.12119
structure: ChemicalStructure/PW C001074

Reference/ChEBI CHEBI 28736
type: UnificationXref
id: CHEBI:28736
db: ChEBI

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0012819
type: UnificationXref
id: HMDB0012819
db: HMDB

Reference/ChemSpider 4444230
type: UnificationXref
id: 4444230
db: ChemSpider

Reference/CAS 70110-58-6
type: UnificationXref
id: 70110-58-6
db: CAS

Compound/PW C001783 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen peroxide
stoichiometric coefficient: 1.0

Compound/PW C002049 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4,6-Dihydroxyquinoline
stoichiometric coefficient: 1.0

Reference/UniProt Q32KQ6
type: UnificationXref
id: Q32KQ6
db: UniProt

Reference/KEGG Compound C00637
type: UnificationXref
id: C00637
db: KEGG Compound

5-Hydroxykynurenamine
type: SmallMolecule
cellular location: Cytosol
entity reference: 5-Hydroxykynurenamine

Reference/BioCyc ANTHRANILATE
type: UnificationXref
id: ANTHRANILATE
db: BioCyc

Reference/KEGG Compound C00632
type: UnificationXref
id: C00632
db: KEGG Compound

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/BioCyc 5-HYDROXYINDOLE ACETATE
type: UnificationXref
id: 5-HYDROXYINDOLE_ACETATE
db: BioCyc

Reference/BioCyc XANTHURENATE
type: UnificationXref
id: XANTHURENATE
db: BioCyc

Compound/PW C000032 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000778
type: ChemicalStructure
structure format: SMILES
structure data: NC1=C(C=CC=C1)C(=O)CC(=O)C(O)=O

Reference/CAS 61-49-4
type: UnificationXref
id: 61-49-4
db: CAS

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Aldehyde dehydrogenase, mitochondrial
type: Complex
component stoichiometry: Protein/15362 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Aldehyde dehydrogenase, mitochondrial

Reference/KEGG Compound C00643
type: UnificationXref
id: C00643
db: KEGG Compound

ChemicalStructure/PW C000538
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC(=O)C1=CC=CC=C1N)C(O)=O

Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 28799
type: UnificationXref
id: CHEBI:28799
db: ChEBI

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Kynurenic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Kynurenic acid

Tryptophan 2,3-dioxygenase
type: Protein
cellular location: Cytosol
entity reference: Tryptophan 2,3-dioxygenase

Reference/ChEBI CHEBI 28790
type: UnificationXref
id: CHEBI:28790
db: ChEBI

Serotonin N-acetyltransferase
type: Protein
cellular location: Cytosol
entity reference: Serotonin N-acetyltransferase

Reference/PubChem-compound 150885
type: UnificationXref
id: 150885
db: PubChem-compound

Reference/UniProt Q3SZK9
type: UnificationXref
id: Q3SZK9
db: UniProt

Reference/ChEBI CHEBI 16796
type: UnificationXref
id: CHEBI:16796
db: ChEBI

Reference/ChemSpider 11318
type: UnificationXref
id: 11318
db: ChemSpider

Reference/ChemSpider 149637
type: UnificationXref
id: 149637
db: ChemSpider

Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
type: Complex
component stoichiometry: Protein/15701 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial

ChemicalStructure/PW C000749
type: ChemicalStructure
structure format: SMILES

2-Aminobenzoic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: 2-Aminobenzoic acid

ChemicalStructure/PW C000991
type: ChemicalStructure
structure format: SMILES
structure data: N\C(=C\C=C/C=O)C(O)=O

Reference/BioCyc TRYPTAMINE
type: UnificationXref
id: TRYPTAMINE
db: BioCyc

L-Tryptophan
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Tryptophan

Reference/UniProt Q0V8S3
type: UnificationXref
id: Q0V8S3
db: UniProt

Acetylserotonin O-methyltransferase
type: Protein
cellular location: Cytosol
entity reference: Acetylserotonin O-methyltransferase

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/PubChem-compound 1066
type: UnificationXref
id: 1066
db: PubChem-compound

Reference/PubChem-compound 24762165
type: UnificationXref
id: 24762165
db: PubChem-compound

Reference/HMDB HMDB0000881
type: UnificationXref
id: HMDB0000881
db: HMDB