Hydroxysteroid 11-beta-dehydrogenase 1-like protein
Corticosteroid 11-beta-dehydrogenase isozyme 2
Corticosteroid 11-beta-dehydrogenase isozyme 1
Steroid 17-alpha-hydroxylase/17,20 lyase
Progesterone (→) Transport: Bos taurus, Cell, Endoplasmic Reticulum to Bos taurus, Cell, Cytoplasm
Cholesterol side-chain cleavage enzyme, mitochondrial
3 beta-hydroxy-delta 5-C27-steroid oxidoreductase
Cortisol + Hydrogen Ion + NADH ↔ 11b,17a,21-Trihydroxypreg-nenolone + NAD
Cortisol + NADP → Cortisone + Hydrogen Ion + NADPH
Corticosterone + NADP → 11-Dehydrocorticosterone + NADPH
3a-Hydroxy-5b-pregnane-20-one + NADP ↔ 5a-Pregnane-3,20-dione + Hydrogen Ion + NADPH
Hydrogen Ion + NADPH + Progesterone ↔ 5a-Pregnane-3,20-dione + NADP
17α,21-Dihydroxypregnenolone + Oxygen + Reduced adrenal ferredoxin → 11b,17a,21-Trihydroxypreg-nenolone + Oxidized adrenal ferredoxin + Water
NADP + Tetrahydrocortisol ↔ Dihydrocortisol + Hydrogen Ion + NADPH
Dihydrocortisol + NADP ↔ Cortisol + Hydrogen Ion + NADPH
NADP + Tetrahydrocortisone ↔ 17a,21-Dihydroxy-5b-pregnane-3,11,20-trione + Hydrogen Ion + NADPH
17a,21-Dihydroxy-5b-pregnane-3,11,20-trione + NADP ↔ Cortisone + Hydrogen Ion + NADPH
20α-Hydroxycholesterol + Hydrogen Ion + NADPH + Oxygen → 17a,20a-Dihydroxycholesterol + NADP + Water
Cholesterol + Hydrogen Ion + Oxygen + Reduced adrenal ferredoxin → 20α-Hydroxycholesterol + Oxidized adrenal ferredoxin + Water
20α-Hydroxycholesterol + Hydrogen Ion + Oxygen + Reduced adrenal ferredoxin → 20a,22b-Dihydroxycholesterol + Oxidized adrenal ferredoxin + Water
Cholesterol + Hydrogen Ion + Oxygen + Reduced adrenal ferredoxin → 22b-Hydroxycholesterol + Oxidized adrenal ferredoxin + Water
22b-Hydroxycholesterol + Hydrogen Ion + Oxygen + Reduced adrenal ferredoxin → 20a,22b-Dihydroxycholesterol + Oxidized adrenal ferredoxin + Water
17a,20a-Dihydroxycholesterol + Hydrogen Ion + Oxygen + Reduced adrenal ferredoxin → 17a-Hydroxypregnenolone + 4-Methylpentanal + Oxidized adrenal ferredoxin + Water
20a,22b-Dihydroxycholesterol + 2 Hydrogen Ion + Oxygen + 2 Reduced adrenal ferredoxin → 4-Methylpentanal + 2 Oxidized adrenal ferredoxin + Pregnenolone + 2 Water
17a-Hydroxypregnenolone + Hydrogen Ion + NADPH + Oxygen ↔ 17α,21-Dihydroxypregnenolone + NADP + Water
Oxygen + Pregnenolone + Reduced acceptor → 17a-Hydroxypregnenolone + Acceptor + Water
Cortexolone + Hydrogen Ion + NADH ← 17α,21-Dihydroxypregnenolone + NAD
17a-Hydroxypregnenolone + NAD → 17-Hydroxyprogesterone + Hydrogen Ion + NADH
17-Hydroxyprogesterone + Oxygen + Reduced acceptor → Acceptor + Cortexolone + Water
Oxygen + Progesterone + Reduced acceptor → 17-Hydroxyprogesterone + Acceptor + Water
Cortexolone + Oxygen + Reduced adrenal ferredoxin → Cortisol + Oxidized adrenal ferredoxin + Water
17-Hydroxyprogesterone + Oxygen + Reduced adrenal ferredoxin → 21-Deoxycortisol + Oxidized adrenal ferredoxin + Water
Oxygen + Pregnenolone + Reduced acceptor → 21-Hydroxypregnenolone + Acceptor + Water
Oxygen + Progesterone + Reduced adrenal ferredoxin → 11b-Hydroxyprogesterone + Oxidized adrenal ferredoxin + Water
NAD + Pregnenolone → Hydrogen Ion + NADH + Progesterone
Oxygen + Progesterone + Reduced acceptor → Acceptor + Deoxycorticosterone + Water
21-Hydroxypregnenolone + NAD → Deoxycorticosterone + Hydrogen Ion + NADH
Deoxycorticosterone + Oxygen + Reduced adrenal ferredoxin → Corticosterone + Oxidized adrenal ferredoxin + Water
21-Deoxycortisol + Oxygen + Reduced acceptor → Acceptor + Cortisol + Water
21-Deoxycortisol + Acceptor + Water → 11b-Hydroxyprogesterone + Oxygen + Reduced acceptor
11b-Hydroxyprogesterone + Oxygen + Reduced acceptor → Acceptor + Corticosterone + Water
3a,21-Dihydroxy-5b-pregnane-11,20-dione + NADP → 21-Hydroxy-5b-pregnane-3,11,20-trione + Hydrogen Ion + NADPH
NADP + Tetrahydrocorticosterone → 3a,21-Dihydroxy-5b-pregnane-11,20-dione + Hydrogen Ion + NADPH
NADP + Tetrahydrocorticosterone ↔ 11b,21-Dihydroxy-5b-pregnane-3,20-dione + NADPH
Corticosterone + Oxygen + Reduced adrenal ferredoxin → 18-Hydroxycorticosterone + Oxidized adrenal ferredoxin + Water
18-Hydroxycorticosterone + Oxygen + Reduced adrenal ferredoxin → Aldosterone + Oxidized adrenal ferredoxin + 2 Water
11b,21-Dihydroxy-3,20-oxo-5b-pregnan-18-al + NADP → Aldosterone + NADPH
11b,21-Dihydroxy-3,20-oxo-5b-pregnan-18-al + NADPH → 3a,11b,21-Trihydroxy-20-oxo-5b-pregnan-18-al + NADP
Corticosterone → 11b,21-Dihydroxy-5b-pregnane-3,20-dione
11-Dehydrocorticosterone → 21-Hydroxy-5b-pregnane-3,11,20-trione