Reference/UniProt F1MPW0
type: UnificationXref
id: F1MPW0
db: UniProt

Reference/UniProt F1N1W2
type: UnificationXref
id: F1N1W2
db: UniProt

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/ChemSpider 392615
type: UnificationXref
id: 392615
db: ChemSpider

Reference/HMDB HMDB0061361
type: UnificationXref
id: HMDB0061361
db: HMDB

Reference/CAS 74465-19-3
type: UnificationXref
id: 74465-19-3
db: CAS

Reference/HMDB HMDB0061362
type: UnificationXref
id: HMDB0061362
db: HMDB

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

1-phosphatidyl-1D-myo-inositol 4,5-biphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: 1-phosphatidyl-1D-myo-inositol 4,5-biphosphate

Reference/UniProt Q3T0K2
type: UnificationXref
id: Q3T0K2
db: UniProt

Inositol 1,3,4,5,6-pentakisphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 16322
xref: Reference/CAS 20298-95-7
xref: Reference/KEGG Compound C01284
xref: Reference/ChemSpider 10333900
xref: Reference/HMDB HMDB0003529
chemical formula: C6H17O21P5
molecular weight: 579.895
structure: ChemicalStructure/PW C001912

Beclin-1
type: Protein
cellular location: Cytosol
entity reference: Beclin-1

Reference/BioCyc GLUCURONATE
type: UnificationXref
id: GLUCURONATE
db: BioCyc

1-phosphatidyl-1D-myo-inositol 4-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: 1-phosphatidyl-1D-myo-inositol 4-phosphate

Reference/ChemSpider 391520
type: UnificationXref
id: 391520
db: ChemSpider

Reference/CAS 6556-12-3
type: UnificationXref
id: 6556-12-3
db: CAS

Reference/HMDB HMDB0001187
type: UnificationXref
id: HMDB0001187
db: HMDB

Reference/TAXONOMY 9913
type: UnificationXref
id: 9913
db: TAXONOMY

Inositol 1,3,4,5-tetraphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 107758
xref: Reference/HMDB HMDB0001059
xref: Reference/KEGG Compound C01272
xref: Reference/ChemSpider 96919
xref: Reference/CAS 102850-29-3
xref: Reference/ChEBI CHEBI 16783
xref: Reference/BioCyc CPD-506
chemical formula: C6H16O18P4
molecular weight: 499.9287
structure: ChemicalStructure/PW C000834

Inositol oxygenase
type: Protein
cellular location: Cytosol
entity reference: Inositol oxygenase

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Inositol Metabolism
type: Pathway
pathway order: PathwayEnzymeReaction/2113034
pathway order: PathwayEnzymeReaction/2113035
pathway order: PathwayEnzymeReaction/2113057
pathway order: PathwayEnzymeReaction/2113054
pathway order: PathwayEnzymeReaction/2113033
pathway order: PathwayEnzymeReaction/2113055
pathway order: PathwayEnzymeReaction/2113038
pathway order: PathwayEnzymeReaction/2113039
pathway order: PathwayEnzymeReaction/2113036
pathway order: PathwayEnzymeReaction/2113037
pathway order: PathwayEnzymeReaction/2113059
pathway order: PathwayEnzymeReaction/2113052
pathway order: PathwayEnzymeReaction/2113053
pathway order: PathwayEnzymeReaction/2113050
pathway order: PathwayEnzymeReaction/2113051
pathway order: PathwayEnzymeReaction/2113045
pathway order: PathwayEnzymeReaction/2113046
pathway order: PathwayEnzymeReaction/2113043
pathway order: PathwayEnzymeReaction/2113044
pathway order: PathwayEnzymeReaction/2113049
pathway order: PathwayEnzymeReaction/2113047
pathway order: PathwayEnzymeReaction/2113048
pathway order: PathwaySubPathway/108306
pathway order: PathwayEnzymeReaction/2113060
pathway order: PathwayEnzymeReaction/2113041
pathway order: PathwayEnzymeReaction/2113042
pathway order: PathwayEnzymeReaction/2113040
pathway component: ReactionCatalysis136762
pathway component: ReactionCatalysis136763
pathway component: ReactionCatalysis136764
pathway component: ReactionCatalysis136765
pathway component: ReactionCatalysis136760
pathway component: ReactionCatalysis136761
pathway component: ReactionCatalysis136766
pathway component: ReactionCatalysis136767
pathway component: ReactionCatalysis136768
pathway component: ReactionCatalysis136769
pathway component: Reaction146616
pathway component: Reaction146615
pathway component: Reaction146614
pathway component: 2.7.1.137
pathway component: 2.7.1.67
pathway component: 2.7.1.150
pathway component: 3.1.4.11
pathway component: Glycerolipid Metabolism
pathway component: ReactionCatalysis136773
pathway component: ReactionCatalysis136774
pathway component: ReactionCatalysis136775
pathway component: ReactionCatalysis136776
pathway component: ReactionCatalysis136770
pathway component: ReactionCatalysis136771
pathway component: ReactionCatalysis136772
pathway component: 3.1.3.57
pathway component: ReactionCatalysis136777
pathway component: 3.1.3.56
pathway component: Reaction146607
pathway component: Reaction146606
pathway component: 3.1.3.66
pathway component: 1.13.99.1
pathway component: Reaction146603
pathway component: Reaction146602
pathway component: Reaction146601
pathway component: 2.7.1.127
pathway component: Reaction146597
pathway component: 2.7.1.158
pathway component: Reaction146595
pathway component: 2.7.1.151
pathway component: 5.5.1.4
pathway component: ReactionCatalysis136753
pathway component: ReactionCatalysis136754
pathway component: ReactionCatalysis136759
pathway component: ReactionCatalysis136755
pathway component: ReactionCatalysis136756
pathway component: ReactionCatalysis136757
pathway component: ReactionCatalysis136758
pathway component: Reaction1385

Compound/PW C040683 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1-phosphatidyl-1D-myo-inositol 4,5-biphosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Adenosine diphosphate
type: SmallMolecule
cellular location: Nucleus
entity reference: Adenosine diphosphate

Reference/ChemSpider 17216102
type: UnificationXref
id: 17216102
db: ChemSpider

Kinase
type: Protein
cellular location: Nucleus
entity reference: Kinase

1D-Myo-inositol 1,3,4,6-tetrakisphosphate
type: SmallMoleculeReference
xref: Reference/ChemSpider 17216082
xref: Reference/CAS 110298-84-5
xref: Reference/BioCyc CPD-505
xref: Reference/HMDB HMDB0001187
xref: Reference/KEGG Compound C04477
xref: Reference/ChEBI CHEBI 16155
chemical formula: C6H16O18P4
molecular weight: 499.9287
structure: ChemicalStructure/PW C000923

Reference/HMDB HMDB0061341
type: UnificationXref
id: HMDB0061341
db: HMDB

Reference/ChemSpider 5743
type: UnificationXref
id: 5743
db: ChemSpider

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Compound/PW C000139 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Myo-inositol 1-phosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16595
type: UnificationXref
id: CHEBI:16595
db: ChEBI

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Reference/BioCyc MYO-INOSITOL
type: UnificationXref
id: MYO-INOSITOL
db: BioCyc

Inositol-tetrakisphosphate 1-kinase
type: Protein
cellular location: Cytosol
entity reference: Inositol-tetrakisphosphate 1-kinase

ChemicalStructure/PW C001083
type: ChemicalStructure
structure format: SMILES

T-complex protein 1 subunit gamma
type: Protein
cellular location: Cytosol
entity reference: T-complex protein 1 subunit gamma

Myo-inositol hexakisphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003502
xref: Reference/ChEBI CHEBI 17401
xref: Reference/CAS 83-86-3
xref: Reference/BioCyc MI-HEXAKISPHOSPHATE
xref: Reference/KEGG Compound C01204
xref: Reference/PubChem-compound 890
xref: Reference/ChemSpider 866
chemical formula: C6H18O24P6
molecular weight: 659.8614
structure: ChemicalStructure/PW C001908

Reference/UniProt P32871
type: UnificationXref
id: P32871
db: UniProt

1D-myo-Inositol 3-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: 1D-myo-Inositol 3-phosphate

Compound/PW C001034 Nucleus/Stoichiometry/2.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 2.0

Reaction1385
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001981 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002108 Cytosol/Stoichiometry/1.0
right: Phosphatidylinositol-3,4,5-trisphosphate
spontaneous: true
left: 1-Phosphatidyl-1D-myo-inositol 3-phosphate
name: 1-Phosphatidyl-1D-myo-inositol 3-phosphate → Phosphatidylinositol-3,4,5-trisphosphate
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0004249
type: UnificationXref
id: HMDB0004249
db: HMDB

Compound/PW C001912 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inositol 1,3,4,5,6-pentakisphosphate
stoichiometric coefficient: 1.0

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Compound/PW C001083 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glucose 6-phosphate
stoichiometric coefficient: 1.0

Compound/PW C000414 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17268
type: UnificationXref
id: CHEBI:17268
db: ChEBI

Reference/ChemSpider 10239179
type: UnificationXref
id: 10239179
db: ChemSpider

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 444791
type: UnificationXref
id: 444791
db: PubChem-compound

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/KEGG Compound C01204
type: UnificationXref
id: C01204
db: KEGG Compound

Compound/PW C000170 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000923
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc 1-PHOSPHATIDYL-MYO-INOSITOL
type: UnificationXref
id: 1-PHOSPHATIDYL-MYO-INOSITOL
db: BioCyc

Reaction146616
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040683 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040527 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Mitochondrion/Stoichiometry/1.0
right: 1-phosphatidyl-1D-myo-inositol 4-phosphate
right: Phosphate
spontaneous: false
left: Water
left: 1-phosphatidyl-1D-myo-inositol 4,5-biphosphate
name: 1-phosphatidyl-1D-myo-inositol 4,5-biphosphate + Water → 1-phosphatidyl-1D-myo-inositol 4-phosphate + Phosphate
conversion direction: LEFT_TO_RIGHT

Reaction146615
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002108 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040683 Cytosol/Stoichiometry/1.0
right: Adenosine triphosphate
right: 1-phosphatidyl-1D-myo-inositol 4,5-biphosphate
spontaneous: false
left: Phosphatidylinositol-3,4,5-trisphosphate
left: Adenosine diphosphate
name: Adenosine diphosphate + Phosphatidylinositol-3,4,5-trisphosphate → 1-phosphatidyl-1D-myo-inositol 4,5-biphosphate + Adenosine triphosphate
conversion direction: LEFT_TO_RIGHT

Reaction146614
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040683 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002108 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Mitochondrion/Stoichiometry/1.0
right: Adenosine diphosphate
right: Phosphatidylinositol-3,4,5-trisphosphate
spontaneous: false
left: Adenosine triphosphate
left: 1-phosphatidyl-1D-myo-inositol 4,5-biphosphate
name: 1-phosphatidyl-1D-myo-inositol 4,5-biphosphate + Adenosine triphosphate → Adenosine diphosphate + Phosphatidylinositol-3,4,5-trisphosphate
conversion direction: LEFT_TO_RIGHT

1D-Myo-inositol 1,3,4,6-tetrakisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: 1D-Myo-inositol 1,3,4,6-tetrakisphosphate

2.7.1.137
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001981 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C003015 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: 1-Phosphatidyl-1D-myo-inositol 3-phosphate
spontaneous: false
EC number: 2.7.1.137
left: 1-Phosphatidyl-D-myo-inositol
left: Adenosine triphosphate
name: 1-Phosphatidyl-D-myo-inositol + Adenosine triphosphate → 1-Phosphatidyl-1D-myo-inositol 3-phosphate + Adenosine diphosphate
conversion direction: LEFT_TO_RIGHT

2.7.1.67
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040527 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C003015 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: 1-phosphatidyl-1D-myo-inositol 4-phosphate
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.1.67
left: 1-Phosphatidyl-D-myo-inositol
left: Adenosine triphosphate
name: 1-Phosphatidyl-D-myo-inositol + Adenosine triphosphate → 1-phosphatidyl-1D-myo-inositol 4-phosphate + Adenosine diphosphate
conversion direction: LEFT_TO_RIGHT

2.7.1.150
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040527 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040683 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: 1-phosphatidyl-1D-myo-inositol 4,5-biphosphate
spontaneous: false
EC number: 2.7.1.150
left: Adenosine triphosphate
left: 1-phosphatidyl-1D-myo-inositol 4-phosphate
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate + Adenosine triphosphate → 1-phosphatidyl-1D-myo-inositol 4,5-biphosphate + Adenosine diphosphate
conversion direction: LEFT_TO_RIGHT

3.1.4.11
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040682 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001155 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040683 Cytosol/Stoichiometry/1.0
right: 1,2-diacylglycerol
right: 1-phosphatidyl-1D-myo-inositol 4,5-biphosphate
spontaneous: false
EC number: 3.1.4.11
left: Inositol 1,4,5-trisphosphate
left: Water
name: Inositol 1,4,5-trisphosphate + Water → 1,2-diacylglycerol + 1-phosphatidyl-1D-myo-inositol 4,5-biphosphate
conversion direction: LEFT_TO_RIGHT

Reference/CAS 7664-38-2
type: UnificationXref
id: 7664-38-2
db: CAS

Reference/BioCyc 1-L-MYO-INOSITOL-1-P
type: UnificationXref
id: 1-L-MYO-INOSITOL-1-P
db: BioCyc

Reference/UniProt E1BGX9
type: UnificationXref
id: E1BGX9
db: UniProt

Reference/BioCyc inositol 1,4,5-trisphosphate
type: UnificationXref
id: inositol_1,4,5-trisphosphate
db: BioCyc

ChemicalStructure/PW C001908
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

1D-Myo-inositol 1,4,5,6-tetrakisphosphate
type: SmallMolecule
cellular location: Nucleus
entity reference: 1D-Myo-inositol 1,4,5,6-tetrakisphosphate

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Compound/PW C002147 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1D-Myo-inositol 1,4,5,6-tetrakisphosphate
stoichiometric coefficient: 1.0

3.1.3.57
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002679 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000923 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytosol/Stoichiometry/1.0
right: 1D-Myo-inositol 3,4-bisphosphate
right: Pyrophosphate
spontaneous: false
EC number: 3.1.3.57
left: 1D-Myo-inositol 1,3,4,6-tetrakisphosphate
left: Water
name: 1D-Myo-inositol 1,3,4,6-tetrakisphosphate + Water → 1D-Myo-inositol 3,4-bisphosphate + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

3.1.3.56
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000892 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000834 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: Inositol 1,3,4-trisphosphate
spontaneous: false
EC number: 3.1.3.56
left: Inositol 1,3,4,5-tetraphosphate
left: Water
name: Inositol 1,3,4,5-tetraphosphate + Water → Inositol 1,3,4-trisphosphate + Phosphate
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/ChemSpider 388561
type: UnificationXref
id: 388561
db: ChemSpider

Reaction146607
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000892 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000834 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: Inositol 1,3,4,5-tetraphosphate
spontaneous: false
left: Inositol 1,3,4-trisphosphate
left: Adenosine triphosphate
name: Adenosine triphosphate + Inositol 1,3,4-trisphosphate → Adenosine diphosphate + Inositol 1,3,4,5-tetraphosphate
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/ChemSpider 388562
type: UnificationXref
id: 388562
db: ChemSpider

Reference/ChEBI CHEBI 16067
type: UnificationXref
id: CHEBI:16067
db: ChEBI

Reaction146606
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000892 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000923 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: 1D-Myo-inositol 1,3,4,6-tetrakisphosphate
right: Adenosine diphosphate
spontaneous: false
left: Adenosine triphosphate
left: Inositol 1,3,4-trisphosphate
name: Adenosine triphosphate + Inositol 1,3,4-trisphosphate → 1D-Myo-inositol 1,3,4,6-tetrakisphosphate + Adenosine diphosphate
conversion direction: LEFT_TO_RIGHT

3.1.3.66
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002679 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002944 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: 1D-myo-Inositol 3-phosphate
spontaneous: false
EC number: 3.1.3.66
left: 1D-Myo-inositol 3,4-bisphosphate
left: Water
name: 1D-Myo-inositol 3,4-bisphosphate + Water → 1D-myo-Inositol 3-phosphate + Phosphate
conversion direction: LEFT_TO_RIGHT

Inositol polyphosphate 1-phosphatase
type: Protein
cellular location: Cytosol
entity reference: Inositol polyphosphate 1-phosphatase

1.13.99.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000137 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000082 Cytosol/Stoichiometry/1.0
right: D-Glucuronic acid
right: Water
spontaneous: false
EC number: 1.13.99.1
left: Oxygen
left: myo-Inositol
name: Oxygen + myo-Inositol → D-Glucuronic acid + Water
conversion direction: LEFT_TO_RIGHT

Reaction146603
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000137 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002944 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: myo-Inositol
spontaneous: false
left: 1D-myo-Inositol 3-phosphate
left: Water
name: 1D-myo-Inositol 3-phosphate + Water → Phosphate + myo-Inositol
conversion direction: LEFT_TO_RIGHT

Reference/UniProt Q2NL29
type: UnificationXref
id: Q2NL29
db: UniProt

Reaction146602
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000137 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000139 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: myo-Inositol
spontaneous: false
left: Myo-inositol 1-phosphate
left: Water
name: Myo-inositol 1-phosphate + Water → Phosphate + myo-Inositol
conversion direction: LEFT_TO_RIGHT

Reaction146601
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001441 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001012 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000137 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: Phosphoric acid
right: myo-Inositol
spontaneous: false
left: D-Myo-inositol 4-phosphate
left: Water
name: D-Myo-inositol 4-phosphate + Water → Phosphoric acid + myo-Inositol
conversion direction: LEFT_TO_RIGHT

Reference/UniProt Q4A1L4
type: UnificationXref
id: Q4A1L4
db: UniProt

3.1.3.57
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001441 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001012 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000772 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: D-Myo-inositol 4-phosphate
right: Phosphoric acid
spontaneous: false
EC number: 3.1.3.57
left: 1D-Myo-inositol 1,4-bisphosphate
left: Water
name: 1D-Myo-inositol 1,4-bisphosphate + Water → D-Myo-inositol 4-phosphate + Phosphoric acid
conversion direction: LEFT_TO_RIGHT

Phosphatidylinositide phosphatase SAC1
type: Protein
cellular location: Cytosol
entity reference: Phosphatidylinositide phosphatase SAC1

Phosphate
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Phosphate

ChemicalStructure/PW C040682
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)OCC(CO)OC(C)=O

ChemicalStructure/PW C040683
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C01220
type: UnificationXref
id: C01220
db: KEGG Compound

Inositol polyphosphate-4-phosphatase type I A
type: Protein
cellular location: Cytosol
entity reference: Inositol polyphosphate-4-phosphatase type I A

Reference/KEGG Compound C00137
type: UnificationXref
id: C00137
db: KEGG Compound

Reference/BioCyc PHOSPHATIDYL-INOSITOL-345-TRISPHOSPHAT
type: UnificationXref
id: PHOSPHATIDYL-INOSITOL-345-TRISPHOSPHAT
db: BioCyc

Reference/ChEBI CHEBI 16155
type: UnificationXref
id: CHEBI:16155
db: ChEBI

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Compound/PW C000414 Nucleus/Stoichiometry/2.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 2.0

Reference/CAS 83-86-3
type: UnificationXref
id: 83-86-3
db: CAS

Reference/ChEBI CHEBI 18348
type: UnificationXref
id: CHEBI:18348
db: ChEBI

Reference/ChEBI CHEBI 18228
type: UnificationXref
id: CHEBI:18228
db: ChEBI

Compound/PW C001155 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate
stoichiometric coefficient: 1.0

Synaptojanin-1
type: Protein
cellular location: Cytosol
entity reference: Synaptojanin-1

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/CAS 102850-29-3
type: UnificationXref
id: 102850-29-3
db: CAS

Reference/ChEBI CHEBI 26078
type: UnificationXref
id: CHEBI:26078
db: ChEBI

Compound/PW C002679 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1D-Myo-inositol 3,4-bisphosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 440194
type: UnificationXref
id: 440194
db: PubChem-compound

Compound/PW C003015 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1-Phosphatidyl-D-myo-inositol
stoichiometric coefficient: 1.0

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: Complex
component stoichiometry: Protein/16922 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/16927 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/16930 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/16934 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Beclin-1
component: PIK3R4 protein
component: Autophagy and beclin 1 regulator 1
component: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

ReactionCatalysis136762
type: Catalysis
controller: Inositol monophosphatase 1
controlled: Reaction146601
control type: ACTIVATION

ReactionCatalysis136763
type: Catalysis
controller: Inositol monophosphatase 1
controlled: Reaction146602
control type: ACTIVATION

ReactionCatalysis136764
type: Catalysis
controller: Inositol monophosphatase 1
controlled: Reaction146603
control type: ACTIVATION

Reference/CAS 110298-84-5
type: UnificationXref
id: 110298-84-5
db: CAS

ReactionCatalysis136765
type: Catalysis
controller: Inositol oxygenase
controlled: 1.13.99.1
control type: ACTIVATION

ReactionCatalysis136760
type: Catalysis
controller: Synaptojanin-1
controlled: 3.1.3.56
control type: ACTIVATION

ReactionCatalysis136761
type: Catalysis
controller: Inositol polyphosphate 1-phosphatase
controlled: 3.1.3.57
control type: ACTIVATION

Reference/KEGG Compound C01243
type: UnificationXref
id: C01243
db: KEGG Compound

Reference/KEGG Compound C03546
type: UnificationXref
id: C03546
db: KEGG Compound

Reference/PubChem-compound 443266
type: UnificationXref
id: 443266
db: PubChem-compound

ReactionCatalysis136766
type: Catalysis
controller: Inositol polyphosphate-4-phosphatase type I A
controlled: 3.1.3.66
control type: ACTIVATION

ReactionCatalysis136767
type: Catalysis
controller: Inositol-tetrakisphosphate 1-kinase
controlled: Reaction146606
control type: ACTIVATION

ChemicalStructure/PW C002108
type: ChemicalStructure
structure format: SMILES

ReactionCatalysis136768
type: Catalysis
controller: Inositol-tetrakisphosphate 1-kinase
controlled: Reaction146607
control type: ACTIVATION

Reference/KEGG Compound C01245
type: UnificationXref
id: C01245
db: KEGG Compound

ReactionCatalysis136769
type: Catalysis
controller: Synaptojanin-1
controlled: 3.1.3.56
control type: ACTIVATION

Phosphatidylinositol-3,4,5-trisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphatidylinositol-3,4,5-trisphosphate

Adenosine diphosphate
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Adenosine diphosphate

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

Myo-inositol 1-phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Myo-inositol 1-phosphate

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])(=O)OP([O-])([O-])=O

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Compound/PW C001912 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inositol 1,3,4,5,6-pentakisphosphate
stoichiometric coefficient: 1.0

ReactionCatalysis136773
type: Catalysis
controller: Phosphatidylinositol 4-kinase alpha
controlled: 2.7.1.67
control type: ACTIVATION

ReactionCatalysis136774
type: Catalysis
controller: Phosphatidylinositol 3-kinase catalytic subunit type 3
controlled: 2.7.1.137
control type: ACTIVATION

ReactionCatalysis136775
type: Catalysis
controller: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
controlled: Reaction146614
control type: ACTIVATION

Autophagy and beclin 1 regulator 1
type: Protein
cellular location: Cytosol
entity reference: Autophagy and beclin 1 regulator 1

ReactionCatalysis136776
type: Catalysis
controller: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
controlled: Reaction146615
control type: ACTIVATION

ReactionCatalysis136770
type: Catalysis
controller: Inositol polyphosphate 1-phosphatase
controlled: 3.1.3.57
control type: ACTIVATION

ReactionCatalysis136771
type: Catalysis
controller: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
controlled: 3.1.4.11
control type: ACTIVATION

ReactionCatalysis136772
type: Catalysis
controller: 1-phosphatidylinositol 3-phosphate 5-kinase
controlled: 2.7.1.150
control type: ACTIVATION

Reference/HMDB HMDB0003529
type: UnificationXref
id: HMDB0003529
db: HMDB

Reference/KEGG Compound C04520
type: UnificationXref
id: C04520
db: KEGG Compound

Reference/UniProt A6QLW1
type: UnificationXref
id: A6QLW1
db: UniProt

ReactionCatalysis136777
type: Catalysis
controller: Protein tyrosine phosphatase, mitochondrial 1
controlled: Reaction146616
control type: ACTIVATION

Reference/ChEBI CHEBI 18169
type: UnificationXref
id: CHEBI:18169
db: ChEBI

ChemicalStructure/PW C001155
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

1D-Myo-inositol 3,4-bisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: 1D-Myo-inositol 3,4-bisphosphate

Reference/KEGG Compound C05981
type: UnificationXref
id: C05981
db: KEGG Compound

1,2-diacylglycerol
type: SmallMolecule
cellular location: Cytosol
entity reference: 1,2-diacylglycerol

Reference/CAS 46495-39-0
type: UnificationXref
id: 46495-39-0
db: CAS

ChemicalStructure/PW C040527
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 17283
type: UnificationXref
id: CHEBI:17283
db: ChEBI

1D-myo-Inositol 3-phosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0006814
xref: Reference/CAS 2831-74-5
xref: Reference/ChemSpider 389182
xref: Reference/PubChem-compound 440194
xref: Reference/KEGG Compound C04006
xref: Reference/ChEBI CHEBI 18169
chemical formula: C6H13O9P
molecular weight: 260.02972
structure: ChemicalStructure/PW C002944

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/ChEBI CHEBI 4170
type: UnificationXref
id: CHEBI:4170
db: ChEBI

Reference/HMDB HMDB0006814
type: UnificationXref
id: HMDB0006814
db: HMDB

D-Myo-inositol 3,4,5,6-tetrakisphosphate
type: SmallMoleculeReference
xref: Reference/ChemSpider 108765
xref: Reference/PubChem-compound 121920
xref: Reference/ChEBI CHEBI 15844
xref: Reference/HMDB HMDB0003848
xref: Reference/KEGG Compound C04520
xref: Reference/CAS 112791-61-4
chemical formula: C6H16O18P4
molecular weight: 499.9287
structure: ChemicalStructure/PW C001980

1-Phosphatidyl-1D-myo-inositol 3-phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C04549
xref: Reference/ChemSpider 5256742
xref: Reference/BioCyc CPD-177
xref: Reference/PubChem-compound 6857403
xref: Reference/ChEBI CHEBI 17283
xref: Reference/HMDB HMDB0003850
chemical formula: C11H20O16P2
molecular weight: 470.02264
structure: ChemicalStructure/PW C001981

Reference/KEGG Compound C01272
type: UnificationXref
id: C01272
db: KEGG Compound

1D-Myo-inositol 1,4-bisphosphate
type: SmallMoleculeReference
xref: Reference/CAS 74465-19-3
xref: Reference/BioCyc INOSITOL-1,4-BISPHOSPHATE
xref: Reference/ChemSpider 17216032
xref: Reference/KEGG Compound C01220
xref: Reference/HMDB HMDB0000968
xref: Reference/ChEBI CHEBI 17816
chemical formula: C6H14O12P2
molecular weight: 339.99606
structure: ChemicalStructure/PW C000772

Inositol 1,3,4-trisphosphate
type: SmallMoleculeReference
xref: Reference/CAS 98102-63-7
xref: Reference/BioCyc INOSITOL-1-3-4-TRIPHOSPHATE
xref: Reference/PubChem-compound 439455
xref: Reference/ChEBI CHEBI 18228
xref: Reference/KEGG Compound C01243
xref: Reference/ChemSpider 388561
xref: Reference/HMDB HMDB0001143
chemical formula: C6H15O15P3
molecular weight: 419.96237
structure: ChemicalStructure/PW C000892

ReactionCatalysis136753
type: Catalysis
controller: Inositol-3-phosphate synthase 1
controlled: 5.5.1.4
control type: ACTIVATION

ReactionCatalysis136754
type: Catalysis
controller: Kinase
controlled: 2.7.1.151
control type: ACTIVATION

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/KEGG Compound C04549
type: UnificationXref
id: C04549
db: KEGG Compound

Phosphoric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphoric acid

ReactionCatalysis136759
type: Catalysis
controller: Kinase
controlled: 2.7.1.127
control type: ACTIVATION

Reference/ChEBI CHEBI 18384
type: UnificationXref
id: CHEBI:18384
db: ChEBI

Protein/16927 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: PIK3R4 protein
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6857403
type: UnificationXref
id: 6857403
db: PubChem-compound

ReactionCatalysis136755
type: Catalysis
controller: Kinase
controlled: 2.7.1.151
control type: ACTIVATION

Reference/PubChem-compound 892
type: UnificationXref
id: 892
db: PubChem-compound

ReactionCatalysis136756
type: Catalysis
controller: Inositol-tetrakisphosphate 1-kinase
controlled: Reaction146595
control type: ACTIVATION

Kinase
type: Protein
cellular location: Cytosol
entity reference: Kinase

ReactionCatalysis136757
type: Catalysis
controller: Inositol-pentakisphosphate 2-kinase
controlled: 2.7.1.158
control type: ACTIVATION

Reference/PubChem-compound 890
type: UnificationXref
id: 890
db: PubChem-compound

ReactionCatalysis136758
type: Catalysis
controller: Multiple inositol polyphosphate histidine phosphatase, 1
controlled: Reaction146597
control type: ACTIVATION

Reference/HMDB HMDB0001498
type: UnificationXref
id: HMDB0001498
db: HMDB

ChemicalStructure/PW C001012
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Reference/KEGG Compound C00191
type: UnificationXref
id: C00191
db: KEGG Compound

Reference/KEGG Compound C01284
type: UnificationXref
id: C01284
db: KEGG Compound

Reference/HMDB HMDB0004527
type: UnificationXref
id: HMDB0004527
db: HMDB

1-phosphatidyl-1D-myo-inositol 4,5-biphosphate
type: SmallMolecule
cellular location: Mitochondrion
entity reference: 1-phosphatidyl-1D-myo-inositol 4,5-biphosphate

Compound/PW C002944 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1D-myo-Inositol 3-phosphate
stoichiometric coefficient: 1.0

Compound/PW C000923 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1D-Myo-inositol 1,3,4,6-tetrakisphosphate
stoichiometric coefficient: 1.0

Inositol-3-phosphate synthase 1
type: Protein
cellular location: Cytoplasm
entity reference: Inositol-3-phosphate synthase 1

Compound/PW C002108 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol-3,4,5-trisphosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Reference/BioCyc CPD-177
type: UnificationXref
id: CPD-177
db: BioCyc

Reference/ChemSpider 979
type: UnificationXref
id: 979
db: ChemSpider

Compound/PW C001980 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Myo-inositol 3,4,5,6-tetrakisphosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Phosphoric acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/ChEBI CHEBI 26078
xref: Reference/CAS 7664-38-2
xref: Reference/PubChem-compound 1004
xref: Reference/ChemSpider 979
xref: Reference/HMDB HMDB0002142
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001441

Reference/HMDB HMDB0006953
type: UnificationXref
id: HMDB0006953
db: HMDB

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Phosphatidylinositol-3,4,5-trisphosphate
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Phosphatidylinositol-3,4,5-trisphosphate

Reference/HMDB HMDB0001143
type: UnificationXref
id: HMDB0001143
db: HMDB

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

SubPathwayInteraction108306
type: Interaction
name: SubPathwayReaction
name: SubPathway108306Reaction
participant: 1-Phosphatidyl-1D-myo-inositol 3-phosphate

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

Reference/KEGG Compound C00092
type: UnificationXref
id: C00092
db: KEGG Compound

ChemicalStructure/PW C003015
type: ChemicalStructure
structure format: SMILES

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: Protein
cellular location: Cytosol
entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Compound/PW C000772 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1D-Myo-inositol 1,4-bisphosphate
stoichiometric coefficient: 1.0

Protein VAC14 homolog
type: Protein
cellular location: Cytosol
entity reference: Protein VAC14 homolog

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

PIK3R4 protein
type: Protein
cellular location: Cytosol
entity reference: PIK3R4 protein

Myo-inositol hexakisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Myo-inositol hexakisphosphate

Reference/CAS 56-73-5
type: UnificationXref
id: 56-73-5
db: CAS

Protein/16907 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositide phosphatase SAC1
stoichiometric coefficient: 1.0

Compound/PW C001441 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoric acid
stoichiometric coefficient: 1.0

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/KEGG Compound C01194
type: UnificationXref
id: C01194
db: KEGG Compound

Nucleus
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005634

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Reference/UniProt F1MLV0
type: UnificationXref
id: F1MLV0
db: UniProt

Reference/PubChem-compound 53477912
type: UnificationXref
id: 53477912
db: PubChem-compound

Reference/UniProt A6QL88
type: UnificationXref
id: A6QL88
db: UniProt

Compound/PW C001104 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 866
type: UnificationXref
id: 866
db: ChemSpider

Adenosine triphosphate
type: SmallMolecule
cellular location: Nucleus
entity reference: Adenosine triphosphate

ChemicalStructure/PW C002147
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0001059
type: UnificationXref
id: HMDB0001059
db: HMDB

Inositol 1,4,5-trisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Inositol 1,4,5-trisphosphate

Reference/HMDB HMDB0002142
type: UnificationXref
id: HMDB0002142
db: HMDB

ChemicalStructure/PW C000082
type: ChemicalStructure
structure format: SMILES

Compound/PW C000139 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Myo-inositol 1-phosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 17215924
type: UnificationXref
id: 17215924
db: ChemSpider

Compound/PW C001981 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1-Phosphatidyl-1D-myo-inositol 3-phosphate
stoichiometric coefficient: 1.0

Reference/PathWhiz PW088261
type: UnificationXref
id: PW088261
db: PathWhiz

Reference/ChEBI CHEBI 15844
type: UnificationXref
id: CHEBI:15844
db: ChEBI

Reference/KEGG Compound C04477
type: UnificationXref
id: C04477
db: KEGG Compound

Reference/UniProt A2VDM2
type: UnificationXref
id: A2VDM2
db: UniProt

D-Myo-inositol 4-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Myo-inositol 4-phosphate

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Glycerolipid Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108306
pathway component: SubPathwayInteraction108306
xref: Reference/PathWhiz PW000144
xref: Reference/SMPDB SMP0000039
name: SubPathway

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Compound/PW C001065 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/KEGG Compound C04006
type: UnificationXref
id: C04006
db: KEGG Compound

D-Glucuronic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Glucuronic acid

Reference/PubChem-compound 1004
type: UnificationXref
id: 1004
db: PubChem-compound

Inositol 1,3,4-trisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Inositol 1,3,4-trisphosphate

D-Myo-inositol 4-phosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001313
xref: Reference/ChEBI CHEBI 18384
xref: Reference/CAS 46495-39-0
xref: Reference/ChemSpider 17216102
xref: Reference/KEGG Compound C03546
xref: Reference/BioCyc D-MYO-INOSITOL-4-PHOSPHATE
chemical formula: C6H13O9P
molecular weight: 260.02972
structure: ChemicalStructure/PW C001012

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
type: Protein
cellular location: Cytosol
entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

1-Phosphatidyl-1D-myo-inositol 3-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: 1-Phosphatidyl-1D-myo-inositol 3-phosphate
name: SubPathwayOutput

Reference/BioCyc INOSITOL-1-3-4-TRIPHOSPHATE
type: UnificationXref
id: INOSITOL-1-3-4-TRIPHOSPHATE
db: BioCyc

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/HMDB HMDB0001401
type: UnificationXref
id: HMDB0001401
db: HMDB

Reference/ChemSpider 108765
type: UnificationXref
id: 108765
db: ChemSpider

Reference/CAS 85166-31-0
type: UnificationXref
id: 85166-31-0
db: CAS

Inositol 1,3,4,5-tetraphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Inositol 1,3,4,5-tetraphosphate

Myo-inositol 1-phosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000213
xref: Reference/ChemSpider 17215924
xref: Reference/CAS 2831-74-5
xref: Reference/KEGG Compound C04006
xref: Reference/BioCyc 1-L-MYO-INOSITOL-1-P
xref: Reference/ChEBI CHEBI 18169
chemical formula: C6H13O9P
molecular weight: 260.02972
structure: ChemicalStructure/PW C000139

myo-Inositol
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000211
xref: Reference/ChEBI CHEBI 17268
xref: Reference/ChemSpider 10239179
xref: Reference/CAS 87-89-8
xref: Reference/BioCyc MYO-INOSITOL
xref: Reference/KEGG Compound C00137
xref: Reference/PubChem-compound 892
chemical formula: C6H12O6
molecular weight: 180.06339
structure: ChemicalStructure/PW C000137

Pyrophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyrophosphate

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: O4P
molecular weight: 94.95342
structure: ChemicalStructure/PW C001104

1D-Myo-inositol 3,4-bisphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 440211
xref: Reference/BioCyc PHOSPHATIDYLINOSITOL-345-TRIPHOSPHATE
xref: Reference/KEGG Compound C04063
xref: Reference/ChEBI CHEBI 28858
xref: Reference/HMDB HMDB0006235
xref: Reference/CAS 69256-53-7
xref: Reference/ChemSpider 389196
chemical formula: C6H14O12P2
molecular weight: 339.99606
structure: ChemicalStructure/PW C002679

Adenosine triphosphate
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Adenosine triphosphate

1-phosphatidylinositol 3-phosphate 5-kinase
type: Complex
component stoichiometry: Protein/16904 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/16910 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/16907 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: T-complex protein 1 subunit gamma
component: Phosphatidylinositide phosphatase SAC1
component: Protein VAC14 homolog

Compound/PW C040527 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1-phosphatidyl-1D-myo-inositol 4-phosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 121920
type: UnificationXref
id: 121920
db: PubChem-compound

Reference/ChemSpider 10333900
type: UnificationXref
id: 10333900
db: ChemSpider

Reference/CAS 87-89-8
type: UnificationXref
id: 87-89-8
db: CAS

Mitochondrion
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005739

1-Phosphatidyl-D-myo-inositol
type: SmallMolecule
cellular location: Cytosol
entity reference: 1-Phosphatidyl-D-myo-inositol

Reference/UniProt P0C0T1
type: UnificationXref
id: P0C0T1
db: UniProt

Compound/PW C001155 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate
stoichiometric coefficient: 1.0

myo-Inositol
type: SmallMolecule
cellular location: Cytosol
entity reference: myo-Inositol

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Reference/HMDB HMDB0000211
type: UnificationXref
id: HMDB0000211
db: HMDB

Reference/HMDB HMDB0000213
type: UnificationXref
id: HMDB0000213
db: HMDB

Phosphatidylinositol 4-kinase alpha
type: Protein
cellular location: Cytosol
entity reference: Phosphatidylinositol 4-kinase alpha

Water
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Water

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])([O-])=O

Inositol-pentakisphosphate 2-kinase
type: ProteinReference
xref: Reference/UniProt E1BGX9
organism: Bos taurus

Reference/ChEBI CHEBI 17816
type: UnificationXref
id: CHEBI:17816
db: ChEBI

Multiple inositol polyphosphate histidine phosphatase, 1
type: ProteinReference
xref: Reference/UniProt Q2TBT6
organism: Bos taurus

Inositol 1,3,4,5,6-pentakisphosphate
type: SmallMolecule
cellular location: Nucleus
entity reference: Inositol 1,3,4,5,6-pentakisphosphate

Reference/CAS 2831-74-5
type: UnificationXref
id: 2831-74-5
db: CAS

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

ChemicalStructure/PW C000139
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0003848
type: UnificationXref
id: HMDB0003848
db: HMDB

ChemicalStructure/PW C000137
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc D-MYO-INOSITOL-4-PHOSPHATE
type: UnificationXref
id: D-MYO-INOSITOL-4-PHOSPHATE
db: BioCyc

ChemicalStructure/PW C002679
type: ChemicalStructure
structure format: SMILES

D-Glucuronic acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00191
xref: Reference/BioCyc GLUCURONATE
xref: Reference/ChemSpider 392615
xref: Reference/HMDB HMDB0000127
xref: Reference/PubChem-compound 444791
xref: Reference/ChEBI CHEBI 42717
xref: Reference/CAS 6556-12-3
chemical formula: C6H10O7
molecular weight: 194.04265
structure: ChemicalStructure/PW C000082

Reference/HMDB HMDB0001313
type: UnificationXref
id: HMDB0001313
db: HMDB

1D-Myo-inositol 1,4,5,6-tetrakisphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0004527
xref: Reference/CAS 121010-58-0
xref: Reference/ChemSpider 391520
xref: Reference/PubChem-compound 443266
xref: Reference/KEGG Compound C11555
xref: Reference/ChEBI CHEBI 16067
chemical formula: C6H16O18P4
molecular weight: 499.9287
structure: ChemicalStructure/PW C002147

Reference/CAS 121010-58-0
type: UnificationXref
id: 121010-58-0
db: CAS

Kinase
type: ProteinReference
xref: Reference/UniProt A4FV33
organism: Bos taurus

Reference/GENE ONTOLOGY GO 0005634
type: UnificationXref
id: GO:0005634
db: GENE ONTOLOGY

Compound/PW C040682 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1,2-diacylglycerol
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16618
type: UnificationXref
id: CHEBI:16618
db: ChEBI

Synaptojanin-1
type: ProteinReference
xref: Reference/UniProt O18964
organism: Bos taurus

Reference/HMDB HMDB0003850
type: UnificationXref
id: HMDB0003850
db: HMDB

Compound/PW C001908 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Myo-inositol hexakisphosphate
stoichiometric coefficient: 1.0

Inositol polyphosphate 1-phosphatase
type: ProteinReference
xref: Reference/UniProt Q1RMJ2
organism: Bos taurus

Reference/BioCyc PHOSPHATIDYLINOSITOL-345-TRIPHOSPHATE
type: UnificationXref
id: PHOSPHATIDYLINOSITOL-345-TRIPHOSPHATE
db: BioCyc

Compound/PW C001034 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Phosphatidylinositol-3,4,5-trisphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0004249
xref: Reference/KEGG Compound C05981
xref: Reference/ChEBI CHEBI 16618
xref: Reference/BioCyc PHOSPHATIDYL-INOSITOL-345-TRISPHOSPHAT
chemical formula: C12H24O22P4
molecular weight: 643.97095
structure: ChemicalStructure/PW C002108

Compound/PW C000082 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glucuronic acid
stoichiometric coefficient: 1.0

Compound/PW C040683 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1-phosphatidyl-1D-myo-inositol 4,5-biphosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001441
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/HMDB HMDB0003502
type: UnificationXref
id: HMDB0003502
db: HMDB

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: O7P2
molecular weight: 173.91193
structure: ChemicalStructure/PW C000170

Reference/PubChem-compound 5958
type: UnificationXref
id: 5958
db: PubChem-compound

Reference/KEGG Compound C04063
type: UnificationXref
id: C04063
db: KEGG Compound

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Inositol monophosphatase 1
type: ProteinReference
xref: Reference/UniProt Q17QE4
organism: Bos taurus

Inositol oxygenase
type: ProteinReference
xref: Reference/UniProt A7MBE4
organism: Bos taurus

Reference/CAS 98102-63-7
type: UnificationXref
id: 98102-63-7
db: CAS

Reference/ChemSpider 5256742
type: UnificationXref
id: 5256742
db: ChemSpider

Reference/ChemSpider 389196
type: UnificationXref
id: 389196
db: ChemSpider

Compound/PW C000834 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inositol 1,3,4,5-tetraphosphate
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Reference/GENE ONTOLOGY GO 0005739
type: UnificationXref
id: GO:0005739
db: GENE ONTOLOGY

Inositol 1,4,5-trisphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001498
xref: Reference/PubChem-compound 439456
xref: Reference/CAS 85166-31-0
xref: Reference/BioCyc inositol 1,4,5-trisphosphate
xref: Reference/KEGG Compound C01245
xref: Reference/ChEBI CHEBI 16595
xref: Reference/ChemSpider 388562
chemical formula: C6H15O15P3
molecular weight: 419.96237
structure: ChemicalStructure/PW C001155

Inositol 1,4,5-trisphosphate
type: SmallMolecule
cellular location: Nucleus
entity reference: Inositol 1,4,5-trisphosphate

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/HMDB HMDB0000127
type: UnificationXref
id: HMDB0000127
db: HMDB

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Inositol polyphosphate-4-phosphatase type I A
type: ProteinReference
xref: Reference/UniProt E1B820
organism: Bos taurus

Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
type: ProteinReference
xref: Reference/UniProt A2VDM2
organism: Bos taurus

Multiple inositol polyphosphate histidine phosphatase, 1
type: Protein
cellular location: Cytosol
entity reference: Multiple inositol polyphosphate histidine phosphatase, 1

1,2-diacylglycerol
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0061362
chemical formula: C7H12O5
molecular weight: 176.06847
structure: ChemicalStructure/PW C040682

1-phosphatidyl-1D-myo-inositol 4,5-biphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 18348
xref: Reference/HMDB HMDB0061361
chemical formula: C11H20O16P2
molecular weight: 470.02264
structure: ChemicalStructure/PW C040683

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Compound/PW C002108 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol-3,4,5-trisphosphate
stoichiometric coefficient: 1.0

D-Myo-inositol 3,4,5,6-tetrakisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Myo-inositol 3,4,5,6-tetrakisphosphate

Compound/PW C040527 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1-phosphatidyl-1D-myo-inositol 4-phosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0006235
type: UnificationXref
id: HMDB0006235
db: HMDB

Glucose 6-phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00092
xref: Reference/BioCyc GLC-6-P
xref: Reference/HMDB HMDB0001401
xref: Reference/PubChem-compound 5958
xref: Reference/ChemSpider 5743
xref: Reference/CAS 56-73-5
xref: Reference/ChEBI CHEBI 4170
chemical formula: C6H13O9P
molecular weight: 260.02972
structure: ChemicalStructure/PW C001083

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/SMPDB SMP0087242
type: UnificationXref
id: SMP0087242
db: SMPDB

Reference/UniProt Q1RMJ2
type: UnificationXref
id: Q1RMJ2
db: UniProt

Reference/ChEBI CHEBI 42717
type: UnificationXref
id: CHEBI:42717
db: ChEBI

Reference/ChEBI CHEBI 16783
type: UnificationXref
id: CHEBI:16783
db: ChEBI

Bos taurus
type: BioSource
xref: Reference/TAXONOMY 9913

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine diphosphate

Reference/ChemSpider 389182
type: UnificationXref
id: 389182
db: ChemSpider

Myo-inositol 1-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Myo-inositol 1-phosphate

Reference/ChemSpider 96919
type: UnificationXref
id: 96919
db: ChemSpider

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Reference/UniProt A2VE70
type: UnificationXref
id: A2VE70
db: UniProt

Inositol monophosphatase 1
type: Protein
cellular location: Cytosol
entity reference: Inositol monophosphatase 1

Inositol-3-phosphate synthase 1
type: ProteinReference
xref: Reference/UniProt Q2NL29
organism: Bos taurus

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: Protein
cellular location: Mitochondrion
entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Compound/PW C001034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001912
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 439455
type: UnificationXref
id: 439455
db: PubChem-compound

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Reference/PubChem-compound 439456
type: UnificationXref
id: 439456
db: PubChem-compound

3.1.3.56
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000772 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000834 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: 1D-Myo-inositol 1,4-bisphosphate
spontaneous: false
EC number: 3.1.3.56
left: Inositol 1,3,4,5-tetraphosphate
left: Water
name: Inositol 1,3,4,5-tetraphosphate + Water → 1D-Myo-inositol 1,4-bisphosphate + Phosphate
conversion direction: LEFT_TO_RIGHT

2.7.1.127
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001155 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000834 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: Inositol 1,3,4,5-tetraphosphate
spontaneous: false
EC number: 2.7.1.127
left: Adenosine triphosphate
left: Inositol 1,4,5-trisphosphate
name: Adenosine triphosphate + Inositol 1,4,5-trisphosphate → Adenosine diphosphate + Inositol 1,3,4,5-tetraphosphate
conversion direction: LEFT_TO_RIGHT

Reaction146597
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001155 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000834 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: Inositol 1,4,5-trisphosphate
spontaneous: false
left: Inositol 1,3,4,5-tetraphosphate
left: Water
name: Inositol 1,3,4,5-tetraphosphate + Water → Inositol 1,4,5-trisphosphate + Phosphate
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 16749
type: UnificationXref
id: CHEBI:16749
db: ChEBI

2.7.1.158
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001912 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001908 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Myo-inositol hexakisphosphate
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.1.158
left: Adenosine triphosphate
left: Inositol 1,3,4,5,6-pentakisphosphate
name: Adenosine triphosphate + Inositol 1,3,4,5,6-pentakisphosphate → Adenosine diphosphate + Myo-inositol hexakisphosphate
conversion direction: LEFT_TO_RIGHT

Reaction146595
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001912 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001980 Cytosol/Stoichiometry/1.0
right: Adenosine triphosphate
right: D-Myo-inositol 3,4,5,6-tetrakisphosphate
spontaneous: false
left: Adenosine diphosphate
left: Inositol 1,3,4,5,6-pentakisphosphate
name: Adenosine diphosphate + Inositol 1,3,4,5,6-pentakisphosphate → Adenosine triphosphate + D-Myo-inositol 3,4,5,6-tetrakisphosphate
conversion direction: LEFT_TO_RIGHT

2.7.1.151
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Nucleus/Stoichiometry/2.0
participant stoichiometry: Compound/PW C002147 Nucleus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Nucleus/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001912 Nucleus/Stoichiometry/1.0
right: Inositol 1,3,4,5,6-pentakisphosphate
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.1.151
left: 1D-Myo-inositol 1,4,5,6-tetrakisphosphate
left: Adenosine triphosphate
name: 1D-Myo-inositol 1,4,5,6-tetrakisphosphate + 2 Adenosine triphosphate → 2 Adenosine diphosphate + Inositol 1,3,4,5,6-pentakisphosphate
conversion direction: LEFT_TO_RIGHT

2.7.1.151
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Nucleus/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001155 Nucleus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Nucleus/Stoichiometry/2.0
participant stoichiometry: Compound/PW C002147 Nucleus/Stoichiometry/1.0
right: 1D-Myo-inositol 1,4,5,6-tetrakisphosphate
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.1.151
left: Inositol 1,4,5-trisphosphate
left: Adenosine triphosphate
name: 2 Adenosine triphosphate + Inositol 1,4,5-trisphosphate → 1D-Myo-inositol 1,4,5,6-tetrakisphosphate + 2 Adenosine diphosphate
conversion direction: LEFT_TO_RIGHT

5.5.1.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001083 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000139 Cytoplasm/Stoichiometry/1.0
right: Myo-inositol 1-phosphate
spontaneous: false
EC number: 5.5.1.4
left: Glucose 6-phosphate
name: Glucose 6-phosphate → Myo-inositol 1-phosphate
conversion direction: LEFT_TO_RIGHT

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Reference/PubChem-compound 107758
type: UnificationXref
id: 107758
db: PubChem-compound

Compound/PW C000137 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: myo-Inositol
stoichiometric coefficient: 1.0

1-phosphatidyl-1D-myo-inositol 4-phosphate
type: SmallMolecule
cellular location: Mitochondrion
entity reference: 1-phosphatidyl-1D-myo-inositol 4-phosphate

Reference/SMPDB SMP0000039
type: UnificationXref
id: SMP0000039
db: SMPDB

Protein/16934 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Autophagy and beclin 1 regulator 1
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Inositol-pentakisphosphate 2-kinase
type: Protein
cellular location: Cytosol
entity reference: Inositol-pentakisphosphate 2-kinase

ChemicalStructure/PW C000834
type: ChemicalStructure
structure format: SMILES

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Reference/BioCyc GLC-6-P
type: UnificationXref
id: GLC-6-P
db: BioCyc

Reference/ChemSpider 17216082
type: UnificationXref
id: 17216082
db: ChemSpider

1-Phosphatidyl-D-myo-inositol
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0006953
xref: Reference/KEGG Compound C01194
xref: Reference/PubChem-compound 53477912
xref: Reference/ChEBI CHEBI 16749
xref: Reference/BioCyc 1-PHOSPHATIDYL-MYO-INOSITOL
chemical formula: C11H19O13P
molecular weight: 390.05634
structure: ChemicalStructure/PW C003015

Reference/ChEBI CHEBI 28858
type: UnificationXref
id: CHEBI:28858
db: ChEBI

Kinase
type: ProteinReference
xref: Reference/UniProt F1N1W2
organism: Bos taurus

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Inositol-tetrakisphosphate 1-kinase
type: ProteinReference
xref: Reference/UniProt P0C0T1
organism: Bos taurus

Reference/PathWhiz PW000144
type: UnificationXref
id: PW000144
db: PathWhiz

T-complex protein 1 subunit gamma
type: ProteinReference
xref: Reference/UniProt Q3T0K2
organism: Bos taurus

Protein/16904 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: T-complex protein 1 subunit gamma
stoichiometric coefficient: 1.0

Phosphatidylinositide phosphatase SAC1
type: ProteinReference
xref: Reference/UniProt A6QL88
organism: Bos taurus

1-phosphatidyl-1D-myo-inositol 4-phosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0061341
xref: Reference/ChEBI CHEBI 17526
chemical formula: C11H19O13P
molecular weight: 390.05634
structure: ChemicalStructure/PW C040527

Reference/HMDB HMDB0000968
type: UnificationXref
id: HMDB0000968
db: HMDB

ChemicalStructure/PW C002944
type: ChemicalStructure
structure format: SMILES

Reference/UniProt Q2NKZ7
type: UnificationXref
id: Q2NKZ7
db: UniProt

ChemicalStructure/PW C001980
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000772
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C001981
type: ChemicalStructure
structure format: SMILES

Reference/UniProt E1B820
type: UnificationXref
id: E1B820
db: UniProt

ChemicalStructure/PW C000892
type: ChemicalStructure
structure format: SMILES

Reference/UniProt Q17QE4
type: UnificationXref
id: Q17QE4
db: UniProt

Protein tyrosine phosphatase, mitochondrial 1
type: Protein
cellular location: Mitochondrion
entity reference: Protein tyrosine phosphatase, mitochondrial 1

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/UniProt A4FV33
type: UnificationXref
id: A4FV33
db: UniProt

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Phosphatidylinositol 4-kinase alpha
type: ProteinReference
xref: Reference/UniProt F1MLV0
organism: Bos taurus

Reference/UniProt A7MBE4
type: UnificationXref
id: A7MBE4
db: UniProt

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphate

Oxygen
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxygen

Reference/CAS 20298-95-7
type: UnificationXref
id: 20298-95-7
db: CAS

Reference/PubChem-compound 440211
type: UnificationXref
id: 440211
db: PubChem-compound

Protein/16930 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Beclin-1
stoichiometric coefficient: 1.0

Inositol 1,3,4,5,6-pentakisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Inositol 1,3,4,5,6-pentakisphosphate

Reference/BioCyc CPD-505
type: UnificationXref
id: CPD-505
db: BioCyc

Protein VAC14 homolog
type: ProteinReference
xref: Reference/UniProt A2VE70
organism: Bos taurus

Reference/BioCyc CPD-506
type: UnificationXref
id: CPD-506
db: BioCyc

Reference/ChEBI CHEBI 17401
type: UnificationXref
id: CHEBI:17401
db: ChEBI

PIK3R4 protein
type: ProteinReference
xref: Reference/UniProt A6QLW1
organism: Bos taurus

Reference/ChEBI CHEBI 17526
type: UnificationXref
id: CHEBI:17526
db: ChEBI

Protein/16922 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
stoichiometric coefficient: 1.0

1D-Myo-inositol 1,4-bisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: 1D-Myo-inositol 1,4-bisphosphate

Reference/BioCyc MI-HEXAKISPHOSPHATE
type: UnificationXref
id: MI-HEXAKISPHOSPHATE
db: BioCyc

Compound/PW C001104 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Compound/PW C001012 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Myo-inositol 4-phosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 17216032
type: UnificationXref
id: 17216032
db: ChemSpider

Reference/CAS 69256-53-7
type: UnificationXref
id: 69256-53-7
db: CAS

Protein/16910 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Protein VAC14 homolog
stoichiometric coefficient: 1.0

Protein tyrosine phosphatase, mitochondrial 1
type: ProteinReference
xref: Reference/UniProt Q2NKZ7
organism: Bos taurus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: Reference/UniProt P32871
organism: Bos taurus

Autophagy and beclin 1 regulator 1
type: ProteinReference
xref: Reference/UniProt F1MPW0
organism: Bos taurus

Reference/ChEBI CHEBI 16322
type: UnificationXref
id: CHEBI:16322
db: ChEBI

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Glucose 6-phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Glucose 6-phosphate

Compound/PW C000892 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inositol 1,3,4-trisphosphate
stoichiometric coefficient: 1.0

Reference/UniProt O18964
type: UnificationXref
id: O18964
db: UniProt

Reference/UniProt Q2TBT6
type: UnificationXref
id: Q2TBT6
db: UniProt

Reference/BioCyc INOSITOL-1,4-BISPHOSPHATE
type: UnificationXref
id: INOSITOL-1,4-BISPHOSPHATE
db: BioCyc

Beclin-1
type: ProteinReference
xref: Reference/UniProt Q4A1L4
organism: Bos taurus

Reference/KEGG Compound C11555
type: UnificationXref
id: C11555
db: KEGG Compound

Reference/CAS 112791-61-4
type: UnificationXref
id: 112791-61-4
db: CAS