Transfer of Acetyl Groups into Mitochondria
type: Pathway
pathway order: PathwayEnzymeReaction/2113353
pathway order: PathwayEnzymeReaction/2113354
pathway order: PathwayEnzymeReaction/2113357
pathway order: PathwayEnzymeReaction/2113358
pathway order: PathwayEnzymeReaction/2113355
pathway order: PathwaySubPathway/108361
pathway order: PathwayEnzymeReaction/2113356
pathway order: PathwayTransport/2113361
pathway order: PathwayTransport/2113362
pathway order: PathwayTransport/2113363
pathway order: PathwayEnzymeReaction/2113359
pathway order: PathwayEnzymeReaction/2113360
pathway component: TransportCatalysis1027
pathway component: TransportCatalysis1026
pathway component: Transport7824
pathway component: ReactionCatalysis135775
pathway component: ReactionCatalysis135774
pathway component: Transport7941
pathway component: ReactionCatalysis136980
pathway component: Transport7940
pathway component: ReactionCatalysis136981
pathway component: TransportCatalysis1002
pathway component: ReactionCatalysis136979
pathway component: ReactionCatalysis135766
pathway component: 2.3.3.8
pathway component: 6.4.1.1
pathway component: Reaction146818
pathway component: Reaction145707
pathway component: 1.1.1.40
pathway component: ReactionCatalysis136978
pathway component: 2.3.3.1
pathway component: 1.2.4.1
pathway component: Reaction1367
pathway component: Fatty Acid Biosynthesis
xref: Reference/SMPDB SMP0087254
xref: Reference/PathWhiz PW088273
organism: Bos taurus

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Oxalacetic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000223
xref: Reference/CAS 328-42-7
xref: Reference/ChEBI CHEBI 30744
xref: Reference/BioCyc OXALACETIC ACID
xref: Reference/ChemSpider 945
xref: Reference/PubChem-compound 970
xref: Reference/KEGG Compound C00036
chemical formula: C4H4O5
molecular weight: 132.00587
structure: ChemicalStructure/PW C000148

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Compound/PW C000164 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 30797
type: UnificationXref
id: CHEBI:30797
db: ChEBI

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Mitochondrial pyruvate carrier 1
type: ProteinReference
xref: Reference/UniProt Q3ZCG2

ATP-citrate synthase
type: Complex
component stoichiometry: Protein/17331 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: ATP-citrate synthase

Reference/BioCyc CIT
type: UnificationXref
id: CIT
db: BioCyc

Compound/PW C000063 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Citric acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000094
type: UnificationXref
id: HMDB0000094
db: HMDB

Acetyl-CoA
type: SmallMolecule
cellular location: Cytosol
entity reference: Acetyl-CoA
name: SubPathwayInput

Reference/PubChem-compound 58838673
type: UnificationXref
id: 58838673
db: PubChem-compound

Reference/TAXONOMY 9913
type: UnificationXref
id: 9913
db: TAXONOMY

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/BioCyc OXALACETIC ACID
type: UnificationXref
id: OXALACETIC_ACID
db: BioCyc

Compound/PW C000143 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

D-Glucose
type: SmallMolecule
cellular location: Mitochondrion
entity reference: D-Glucose

Pyruvate carboxylase, mitochondrial
type: Complex
component stoichiometry: Protein/14905 Mitochondrion/Stoichiometry/4.0
cellular location: Mitochondrion
component: Pyruvate carboxylase, mitochondrial

Compound/PW C000148 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxalacetic acid
stoichiometric coefficient: 1.0

Reference/CAS 328-42-7
type: UnificationXref
id: 328-42-7
db: CAS

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

ChemicalStructure/PW C000101
type: ChemicalStructure
structure format: SMILES
structure data: O[C@@H](CC(O)=O)C(O)=O

ChemicalStructure/PW C000463
type: ChemicalStructure
structure format: SMILES
structure data: OC([O-])=O

Malate dehydrogenase, cytoplasmic
type: Protein
cellular location: Cytosol
entity reference: Malate dehydrogenase, cytoplasmic

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Pyruvic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 1060
xref: Reference/HMDB HMDB0000243
xref: Reference/CAS 127-17-3
xref: Reference/BioCyc PYRUVATE
xref: Reference/KEGG Compound C00022
xref: Reference/ChEBI CHEBI 32816
xref: Reference/ChemSpider 1031
chemical formula: C3H4O3
molecular weight: 88.016045
structure: ChemicalStructure/PW C000164

Reaction1367
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000164 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000077 Mitochondrion/Stoichiometry/1.0
right: Pyruvic acid
spontaneous: false
left: D-Glucose
name: D-Glucose → Pyruvic acid
conversion direction: LEFT_TO_RIGHT

Reference/PathWhiz PW000167
type: UnificationXref
id: PW000167
db: PathWhiz

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Protein/14848 Mitochondrial Matrix/Stoichiometry/2.0
type: Stoichiometry
physical entity: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
stoichiometric coefficient: 2.0

Reference/BioCyc HCO3
type: UnificationXref
id: HCO3
db: BioCyc

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/UniProt Q58CN6
type: UnificationXref
id: Q58CN6
db: UniProt

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/CAS 2280-44-6
type: UnificationXref
id: 2280-44-6
db: CAS

Reference/BioCyc ALPHA-GLUCOSE-16-BISPHOSPHATE
type: UnificationXref
id: ALPHA-GLUCOSE-16-BISPHOSPHATE
db: BioCyc

Pyruvate dehydrogenase E1
type: Complex
component stoichiometry: Protein/14843 Mitochondrial Matrix/Stoichiometry/2.0
component stoichiometry: Protein/14848 Mitochondrial Matrix/Stoichiometry/2.0
cellular location: Mitochondrial Matrix
component: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
component: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

Compound/PW C000101 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Malic acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Citric acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Citric acid

Reference/CAS 97-67-6
type: UnificationXref
id: 97-67-6
db: CAS

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: O4P
molecular weight: 94.95342
structure: ChemicalStructure/PW C001104

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

Reference/ChemSpider 945
type: UnificationXref
id: 945
db: ChemSpider

Reference/CAS 77-92-9
type: UnificationXref
id: 77-92-9
db: CAS

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

Compound/PW C000063 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Citric acid
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Adenosine triphosphate

Reference/ChEBI CHEBI 30769
type: UnificationXref
id: CHEBI:30769
db: ChEBI

Compound/PW C000148 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxalacetic acid
stoichiometric coefficient: 1.0

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H29N7O17P3
molecular weight: 744.08325
structure: ChemicalStructure/PW C000143

Mitochondrion
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005739

Compound/PW C000414 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/UniProt B8YB77
type: UnificationXref
id: B8YB77
db: UniProt

Compound/PW C000146 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Reference/UniProt Q866R1
type: UnificationXref
id: Q866R1
db: UniProt

Carbon dioxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbon dioxide

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

L-Malic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Malic acid

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])([O-])=O

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Compound/PW C001051 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen
stoichiometric coefficient: 1.0

D-Glucose
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000122
xref: Reference/PubChem-compound 5793
xref: Reference/CAS 2280-44-6
xref: Reference/ChemSpider 5589
xref: Reference/ChEBI CHEBI 4167
xref: Reference/BioCyc GLC
xref: Reference/KEGG Compound C00031
chemical formula: C6H12O6
molecular weight: 180.06339
structure: ChemicalStructure/PW C000077

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Compound/PW C000940 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Malic enzyme
type: Protein
cellular location: Cytosol
entity reference: Malic enzyme

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/BioCyc GLC
type: UnificationXref
id: GLC
db: BioCyc

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Compound/PW C000721 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Pyruvic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Pyruvic acid

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

NADPH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADPH

Compound/PW C000148 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxalacetic acid
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/ChemSpider 1031
type: UnificationXref
id: 1031
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Reference/HMDB HMDB0000223
type: UnificationXref
id: HMDB0000223
db: HMDB

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/GENE ONTOLOGY GO 0005759
type: UnificationXref
id: GO:0005759
db: GENE ONTOLOGY

Coenzyme A
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Coenzyme A

Hydrogen
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen

Compound/PW C000164 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 1.0

Phosphate
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Phosphate

Hydrogen
type: SmallMoleculeReference
xref: Reference/PubChem-compound 58838673
xref: Reference/CAS 1333-74-0
xref: Reference/ChemSpider 762
xref: Reference/BioCyc ALPHA-GLUCOSE-16-BISPHOSPHATE
xref: Reference/KEGG Compound C00282
xref: Reference/HMDB HMDB0001362
xref: Reference/ChEBI CHEBI 18276
chemical formula: H2
molecular weight: 2.01565
structure: ChemicalStructure/PW C001051

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Pyruvic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyruvic acid

Coenzyme A
type: SmallMolecule
cellular location: Cytosol
entity reference: Coenzyme A

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H28N7O14P2
molecular weight: 664.11694
structure: ChemicalStructure/PW C000721

Mitochondrial 2-oxoglutarate/malate carrier protein
type: Protein
entity reference: Mitochondrial 2-oxoglutarate/malate carrier protein

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Compound/PW C001034 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Reference/UniProt Q29RK1
type: UnificationXref
id: Q29RK1
db: UniProt

Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000595
type: UnificationXref
id: HMDB0000595
db: HMDB

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

Pyruvate carboxylase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q866R1
organism: Bos taurus

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Compound/PW C000463 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen carbonate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00149
type: UnificationXref
id: C00149
db: KEGG Compound

Compound/PW C000077 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glucose
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00022
type: UnificationXref
id: C00022
db: KEGG Compound

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Citrate synthase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Citrate synthase, mitochondrial

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

Reference/HMDB HMDB0000243
type: UnificationXref
id: HMDB0000243
db: HMDB

ATP-citrate synthase
type: Protein
cellular location: Cytosol
entity reference: ATP-citrate synthase

Reference/HMDB HMDB0000122
type: UnificationXref
id: HMDB0000122
db: HMDB

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Reference/GENE ONTOLOGY GO 0005739
type: UnificationXref
id: GO:0005739
db: GENE ONTOLOGY

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

1.2.4.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Mitochondrial Matrix/Stoichiometry/1.0
right: Acetyl-CoA
spontaneous: false
EC number: 1.2.4.1
left: Pyruvic acid
name: Pyruvic acid → Acetyl-CoA
conversion direction: LEFT_TO_RIGHT

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

NADP
type: SmallMolecule
cellular location: Cytosol
entity reference: NADP

Citric acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 30769
xref: Reference/BioCyc CIT
xref: Reference/HMDB HMDB0000094
xref: Reference/PubChem-compound 19782904
xref: Reference/KEGG Compound C00158
xref: Reference/CAS 77-92-9
xref: Reference/ChemSpider 305
chemical formula: C6H8O7
molecular weight: 192.02701
structure: ChemicalStructure/PW C000063

Protein/17331 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: ATP-citrate synthase
stoichiometric coefficient: 4.0

Protein/14843 Mitochondrial Matrix/Stoichiometry/2.0
type: Stoichiometry
physical entity: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
stoichiometric coefficient: 2.0

Reference/PubChem-compound 769
type: UnificationXref
id: 769
db: PubChem-compound

NADP-dependent malic enzyme
type: Complex
component stoichiometry: Protein/16353 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Malic enzyme

NADH
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NADH

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

2.3.3.8
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001099 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000063 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000148 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: Oxalacetic acid
right: Acetyl-CoA
spontaneous: false
EC number: 2.3.3.8
left: Adenosine triphosphate
left: Coenzyme A
left: Citric acid
name: Adenosine triphosphate + Citric acid + Coenzyme A → Acetyl-CoA + Adenosine diphosphate + Oxalacetic acid
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 19782904
type: UnificationXref
id: 19782904
db: PubChem-compound

Reference/KEGG Compound C00031
type: UnificationXref
id: C00031
db: KEGG Compound

Reaction146818
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001051 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000148 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000101 Cytosol/Stoichiometry/1.0
right: NAD
right: L-Malic acid
spontaneous: false
left: Oxalacetic acid
left: Hydrogen
left: NADPH
name: Hydrogen + NADPH + Oxalacetic acid → L-Malic acid + NAD
conversion direction: LEFT_TO_RIGHT

1.1.1.40
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001051 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000101 Cytosol/Stoichiometry/1.0
right: Pyruvic acid
right: Hydrogen
right: Carbon dioxide
right: NADPH
spontaneous: false
EC number: 1.1.1.40
left: NADP
left: L-Malic acid
name: L-Malic acid + NADP → Carbon dioxide + Hydrogen + NADPH + Pyruvic acid
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00158
type: UnificationXref
id: C00158
db: KEGG Compound

Reference/ChEBI CHEBI 18276
type: UnificationXref
id: CHEBI:18276
db: ChEBI

Reference/KEGG Compound C00036
type: UnificationXref
id: C00036
db: KEGG Compound

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

Oxalacetic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Oxalacetic acid

SubPathwayInteraction108361
type: Interaction
name: SubPathwayReaction
name: SubPathway108361Reaction
participant: Acetyl-CoA

Reference/KEGG Compound C00282
type: UnificationXref
id: C00282
db: KEGG Compound

Oxalacetic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxalacetic acid

Reference/UniProt Q3T145
type: UnificationXref
id: Q3T145
db: UniProt

Adenosine diphosphate
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Adenosine diphosphate

Mitochondrial Matrix
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005759

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Transport7824
type: Transport
participant stoichiometry: Compound/PW C000164 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Mitochondrial Matrix/Stoichiometry/1.0
right: Pyruvic acid
spontaneous: false
left: Pyruvic acid
name: Pyruvic acid (→) Transport: Bos taurus, Cell, Cytosol to Bos taurus, Cell, Mitochondrial Matrix
conversion direction: LEFT_TO_RIGHT

Transport7941
type: Transport
participant stoichiometry: Compound/PW C000101 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000101 Cytosol/Stoichiometry/1.0
right: L-Malic acid
spontaneous: false
left: L-Malic acid
name: L-Malic acid (→) Transport: Bos taurus, Cell, Cytosol to Bos taurus, Cell, Mitochondrion
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Transport7940
type: Transport
participant stoichiometry: Compound/PW C000063 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000063 Cytosol/Stoichiometry/1.0
right: Citric acid
spontaneous: false
left: Citric acid
name: Citric acid (←) Transport: Bos taurus, Cell, Cytosol to Bos taurus, Cell, Mitochondrial Matrix
conversion direction: LEFT_TO_RIGHT

Citrate synthase, mitochondrial
type: Complex
component stoichiometry: Protein/14861 Mitochondrial Matrix/Stoichiometry/2.0
cellular location: Mitochondrial Matrix
component: Citrate synthase, mitochondrial

Reference/PubChem-compound 222656
type: UnificationXref
id: 222656
db: PubChem-compound

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

Reference/KEGG Compound C00288
type: UnificationXref
id: C00288
db: KEGG Compound

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 762
type: UnificationXref
id: 762
db: ChemSpider

Reference/UniProt Q32PF2
type: UnificationXref
id: Q32PF2
db: UniProt

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

ChemicalStructure/PW C000063
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC(O)(CC(O)=O)C(O)=O

Bos taurus
type: BioSource
xref: Reference/TAXONOMY 9913

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine diphosphate

Protein/16353 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Malic enzyme
stoichiometric coefficient: 4.0

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Compound/PW C001144 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

L-Malic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Malic acid

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Pyruvate carboxylase, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Pyruvate carboxylase, mitochondrial

ReactionCatalysis135775
type: Catalysis
controller: Pyruvate carboxylase, mitochondrial
controlled: 6.4.1.1
control type: ACTIVATION

ReactionCatalysis135774
type: Catalysis
controller: Malate dehydrogenase, cytoplasmic
controlled: Reaction145707
control type: ACTIVATION

Reference/ChemSpider 5589
type: UnificationXref
id: 5589
db: ChemSpider

ReactionCatalysis136980
type: Catalysis
controller: ATP-citrate synthase
controlled: 2.3.3.8
control type: ACTIVATION

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

Reference/SMPDB SMP0087254
type: UnificationXref
id: SMP0087254
db: SMPDB

ReactionCatalysis136981
type: Catalysis
controller: Pyruvate dehydrogenase E1
controlled: 1.2.4.1
control type: ACTIVATION

Hydrogen carbonate
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Hydrogen carbonate

ChemicalStructure/PW C000148
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC(=O)C(O)=O

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

Oxalacetic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Oxalacetic acid

6.4.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000164 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000463 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000148 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Mitochondrion/Stoichiometry/1.0
right: Adenosine diphosphate
right: Phosphate
right: Oxalacetic acid
spontaneous: false
EC number: 6.4.1.1
left: Adenosine triphosphate
left: Hydrogen carbonate
left: Pyruvic acid
name: Adenosine triphosphate + Hydrogen carbonate + Pyruvic acid → Adenosine diphosphate + Oxalacetic acid + Phosphate
conversion direction: LEFT_TO_RIGHT

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reaction145707
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000148 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000101 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytoplasm/Stoichiometry/1.0
right: Hydrogen Ion
right: NADH
right: Oxalacetic acid
spontaneous: false
left: NAD
left: L-Malic acid
name: L-Malic acid + NAD ↔ Hydrogen Ion + NADH + Oxalacetic acid
conversion direction: REVERSIBLE

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Compound/PW C001034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000156
type: UnificationXref
id: HMDB0000156
db: HMDB

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Hydrogen Ion
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Hydrogen Ion

Reference/CAS 127-17-3
type: UnificationXref
id: 127-17-3
db: CAS

Pyruvic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Pyruvic acid

Unknown
type: Protein
entity reference: Unknown

Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001362
type: UnificationXref
id: HMDB0001362
db: HMDB

Fatty Acid Biosynthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108361
pathway component: SubPathwayInteraction108361
xref: Reference/PathWhiz PW000167
xref: Reference/SMPDB SMP0000456
name: SubPathway

NAD
type: SmallMolecule
cellular location: Cytosol
entity reference: NAD

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Reference/ChemSpider 305
type: UnificationXref
id: 305
db: ChemSpider

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Compound/PW C000101 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Malic acid
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000164
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)C(O)=O

Malate dehydrogenase, cytoplasmic
type: Protein
cellular location: Cytoplasm
entity reference: Malate dehydrogenase, cytoplasmic

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
type: ProteinReference
xref: Reference/UniProt A7MB35
organism: Bos taurus

Reference/CAS 1333-74-0
type: UnificationXref
id: 1333-74-0
db: CAS

Reference/ChEBI CHEBI 17544
type: UnificationXref
id: CHEBI:17544
db: ChEBI

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

TransportCatalysis1002
type: Catalysis
controller: Mitochondrial pyruvate carrier 1
controlled: Transport7824
control type: ACTIVATION

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Water
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Water

Malate dehydrogenase, cytoplasmic
type: ProteinReference
xref: Reference/UniProt Q3T145
organism: Bos taurus

Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q58CN6
organism: Bos taurus

Reference/ChEBI CHEBI 32816
type: UnificationXref
id: CHEBI:32816
db: ChEBI

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Mitochondrial pyruvate carrier 1
type: Protein
entity reference: Mitochondrial pyruvate carrier 1

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/BioCyc PYRUVATE
type: UnificationXref
id: PYRUVATE
db: BioCyc

Reference/SMPDB SMP0000456
type: UnificationXref
id: SMP0000456
db: SMPDB

ReactionCatalysis136979
type: Catalysis
controller: Malate dehydrogenase, cytoplasmic
controlled: Reaction146818
control type: ACTIVATION

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

ReactionCatalysis135766
type: Catalysis
controller: Citrate synthase, mitochondrial
controlled: 2.3.3.1
control type: ACTIVATION

L-Malic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: L-Malic acid

Reference/UniProt Q5E9W4
type: UnificationXref
id: Q5E9W4
db: UniProt

ReactionCatalysis136978
type: Catalysis
controller: NADP-dependent malic enzyme
controlled: 1.1.1.40
control type: ACTIVATION

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Reference/ChEBI CHEBI 4167
type: UnificationXref
id: CHEBI:4167
db: ChEBI

Malic enzyme
type: ProteinReference
xref: Reference/UniProt B8YB77
organism: Bos taurus

Reference/ChEBI CHEBI 30744
type: UnificationXref
id: CHEBI:30744
db: ChEBI

Oxalacetic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Oxalacetic acid

TransportCatalysis1027
type: Catalysis
controller: Mitochondrial 2-oxoglutarate/malate carrier protein
controlled: Transport7941
control type: ACTIVATION

Reference/PubChem-compound 5793
type: UnificationXref
id: 5793
db: PubChem-compound

TransportCatalysis1026
type: Catalysis
controller: Unknown
controlled: Transport7940
control type: ACTIVATION

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

Citrate synthase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q29RK1
organism: Bos taurus

Compound/PW C000721 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Compound/PW C000148 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxalacetic acid
stoichiometric coefficient: 1.0

Compound/PW C001104 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Protein/14861 Mitochondrial Matrix/Stoichiometry/2.0
type: Stoichiometry
physical entity: Citrate synthase, mitochondrial
stoichiometric coefficient: 2.0

ChemicalStructure/PW C000077
type: ChemicalStructure
structure format: SMILES
structure data: OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Compound/PW C001099 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

Citric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Citric acid

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

ATP-citrate synthase
type: ProteinReference
xref: Reference/UniProt Q32PF2
organism: Bos taurus

Reference/ChemSpider 193317
type: UnificationXref
id: 193317
db: ChemSpider

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Protein/14905 Mitochondrion/Stoichiometry/4.0
type: Stoichiometry
physical entity: Pyruvate carboxylase, mitochondrial
stoichiometric coefficient: 4.0

Reference/PubChem-compound 1060
type: UnificationXref
id: 1060
db: PubChem-compound

Mitochondrial 2-oxoglutarate/malate carrier protein
type: ProteinReference
xref: Reference/UniProt Q5E9W4

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Reference/PathWhiz PW088273
type: UnificationXref
id: PW088273
db: PathWhiz

Compound/PW C001316 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Compound/PW C000101 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Malic acid
stoichiometric coefficient: 1.0

Compound/PW C000164 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 749
type: UnificationXref
id: 749
db: ChemSpider

Reference/CAS 71-52-3
type: UnificationXref
id: 71-52-3
db: CAS

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

Unknown
type: ProteinReference

Reference/PubChem-compound 970
type: UnificationXref
id: 970
db: PubChem-compound

Acetyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Acetyl-CoA

2.3.3.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000063 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000148 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
right: Coenzyme A
right: Citric acid
spontaneous: false
EC number: 2.3.3.1
left: Acetyl-CoA
left: Water
left: Oxalacetic acid
name: Acetyl-CoA + Oxalacetic acid + Water → Citric acid + Coenzyme A
conversion direction: LEFT_TO_RIGHT

L-Malic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000156
xref: Reference/ChEBI CHEBI 30797
xref: Reference/KEGG Compound C00149
xref: Reference/ChemSpider 193317
xref: Reference/PubChem-compound 222656
xref: Reference/CAS 97-67-6
chemical formula: C4H6O5
molecular weight: 134.02153
structure: ChemicalStructure/PW C000101

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

NAD
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NAD

Hydrogen carbonate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000595
xref: Reference/ChEBI CHEBI 17544
xref: Reference/PubChem-compound 769
xref: Reference/BioCyc HCO3
xref: Reference/ChemSpider 749
xref: Reference/CAS 71-52-3
xref: Reference/KEGG Compound C00288
chemical formula: CHO3
molecular weight: 60.99257
structure: ChemicalStructure/PW C000463

Reference/UniProt A7MB35
type: UnificationXref
id: A7MB35
db: UniProt

ChemicalStructure/PW C001051
type: ChemicalStructure
structure format: SMILES
structure data: [H][H]

Reference/UniProt Q3ZCG2
type: UnificationXref
id: Q3ZCG2
db: UniProt