Reference/UniProt P80025
type: UnificationXref
id: P80025
db: UniProt

Cytochrome b-245 heavy chain
type: ProteinReference
xref: Reference/UniProt A4IF96
organism: Bos taurus

Protein/17630 Endocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thyroglobulin
stoichiometric coefficient: 1.0

ReactionCatalysis168759
type: Catalysis
controller: Thyroid peroxidase
controlled: 1.11.1.8
control type: ACTIVATION

Reference/CAS 7722-84-1
type: UnificationXref
id: 7722-84-1
db: CAS

Reference/ChemSpider 28015
type: UnificationXref
id: 28015
db: ChemSpider

Reference/HMDB HMDB0012238
type: UnificationXref
id: HMDB0012238
db: HMDB

Reference/PubChem-compound 923
type: UnificationXref
id: 923
db: PubChem-compound

TransportCatalysis1044
type: Catalysis
controller: Unknown
controlled: Transport7971
control type: ACTIVATION

Thyroglobulin
type: Protein
cellular location: Cytosol
entity reference: Thyroglobulin

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/GENE ONTOLOGY GO 0030139
type: UnificationXref
id: GO:0030139
db: GENE ONTOLOGY

Thyroglobulin secretion
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108399
pathway component: SubPathwayInteraction108399
name: SubPathway

Reference/CAS 20461-54-5
type: UnificationXref
id: 20461-54-5
db: CAS

Reference/ChemSpider 899
type: UnificationXref
id: 899
db: ChemSpider

Sodium
type: SmallMolecule
entity reference: Sodium

Reference/PubChem-compound 25201348
type: UnificationXref
id: 25201348
db: PubChem-compound

Reference/HMDB HMDB0003125
type: UnificationXref
id: HMDB0003125
db: HMDB

Protein/17644 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cytochrome b-245 light chain
stoichiometric coefficient: 1.0

Reference/BioCyc HYDROGEN-PEROXIDE
type: UnificationXref
id: HYDROGEN-PEROXIDE
db: BioCyc

ChemicalStructure/PW C001783
type: ChemicalStructure
structure format: SMILES
structure data: OO

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/GENE ONTOLOGY GO 0070382
type: UnificationXref
id: GO:0070382
db: GENE ONTOLOGY

Thyroglobulin
type: ProteinReference
xref: Reference/UniProt Q95478
organism: Bos taurus

TransportCatalysis1043
type: Catalysis
controller: Sodium-coupled monocarboxylate transporter 2
controlled: Transport7970
control type: ACTIVATION

Reference/BioCyc L-THYROXINE
type: UnificationXref
id: L-THYROXINE
db: BioCyc

Lactoperoxidase
type: ProteinReference
xref: Reference/UniProt P80025
organism: Bos taurus

Cytochrome b-245 heavy chain
type: Protein
cellular location: Cytosol
entity reference: Cytochrome b-245 heavy chain

Compound/PW C000169 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thyroxine
stoichiometric coefficient: 1.0

Compound/PW C000181 Endocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: Liothyronine
stoichiometric coefficient: 1.0

Reference/TAXONOMY 9913
type: UnificationXref
id: 9913
db: TAXONOMY

1.11.1.8
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001783 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/17630 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007784 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/2.0
right: Thyroglobulin
right: Water
spontaneous: false
EC number: 1.11.1.8
left: Thyroglobulin
left: Iodide
left: Hydrogen peroxide
name: Hydrogen peroxide + Iodide + [thyroglobulin]-3-iodo-L-tyrosine → 2 Water + [thyroglobulin]-3,5-diiodo-L-tyrosine
conversion direction: LEFT_TO_RIGHT

Thyroglobulin
type: Protein
cellular location: Extracellular Space
entity reference: Thyroglobulin

1.11.1.8
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001783 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/17630 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007784 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: Thyroglobulin
right: Water
spontaneous: false
EC number: 1.11.1.8
left: Thyroglobulin
left: Iodide
left: Hydrogen peroxide
name: Hydrogen peroxide + Iodide + Thyroglobulin with L-Tyrosine → Water + [thyroglobulin]-3-iodo-L-tyrosine
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc CPD-387
type: UnificationXref
id: CPD-387
db: BioCyc

1.11.1.8
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001783 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/17630 Cytosol/Stoichiometry/2.0
participant stoichiometry: Protein/17630 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/2.0
right: Thyroglobulin
right: Water
spontaneous: false
EC number: 1.11.1.8
left: Thyroglobulin
left: Hydrogen peroxide
name: Hydrogen peroxide + 2 [thyroglobulin]-3,5-diiodo-L-tyrosine → 2 Water + [thyroglobulin]-3,5,3'-triiodo-L-thyronine + [thyroglobulin]-aminoacrylate
conversion direction: LEFT_TO_RIGHT

1.11.1.8
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001783 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/17630 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007784 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/2.0
right: Thyroglobulin
right: Water
spontaneous: false
EC number: 1.11.1.8
left: Thyroglobulin
left: Iodide
left: Hydrogen peroxide
name: Hydrogen peroxide + Iodide + [thyroglobulin]-3,5,3'-triiodo-L-thyronine → 2 Water + [thyroglobulin]-thyroxine
conversion direction: LEFT_TO_RIGHT

Reference/UniProt Q95478
type: UnificationXref
id: Q95478
db: UniProt

ChemicalStructure/PW C000458
type: ChemicalStructure
structure format: SMILES
structure data: [Na+]

Protein/17636 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Lactoperoxidase
stoichiometric coefficient: 2.0

Reference/ChEBI CHEBI 16382
type: UnificationXref
id: CHEBI:16382
db: ChEBI

Reference/KEGG Compound C02465
type: UnificationXref
id: C02465
db: KEGG Compound

Reference/HMDB HMDB0000265
type: UnificationXref
id: HMDB0000265
db: HMDB

Reference/ChemSpider 763
type: UnificationXref
id: 763
db: ChemSpider

Cytochrome b-245 light chain
type: Protein
cellular location: Cytosol
entity reference: Cytochrome b-245 light chain

Bos taurus
type: BioSource
xref: Reference/TAXONOMY 9913

Compound/PW C001420 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 2.0

Cytochrome b-245 light chain
type: ProteinReference
xref: Reference/UniProt A5PK68
organism: Bos taurus

ChemicalStructure/PW C000181
type: ChemicalStructure
structure format: SMILES

Reference/CAS 17341-25-2
type: UnificationXref
id: 17341-25-2
db: CAS

Transport7979
type: Transport
participant stoichiometry: Compound/PW C000181 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000181 Cytosol/Stoichiometry/1.0
right: Liothyronine
spontaneous: false
left: Liothyronine
name: Liothyronine (→) Transport: Bos taurus, Cell, Cytosol to Bos taurus, Cell, Exocytic Vesicle
conversion direction: LEFT_TO_RIGHT

Transport7978
type: Transport
participant stoichiometry: Compound/PW C000181 Endocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000181 Cytosol/Stoichiometry/1.0
right: Liothyronine
spontaneous: false
left: Liothyronine
name: Liothyronine (→) Transport: Bos taurus, Cell, Endocytic Vesicle to Bos taurus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 784
type: UnificationXref
id: 784
db: PubChem-compound

Transport7977
type: Transport
participant stoichiometry: Compound/PW C000181 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000181 Exocytic Vesicle/Stoichiometry/1.0
right: Liothyronine
spontaneous: false
left: Liothyronine
name: Liothyronine (→) Transport: Bos taurus, Cell, Exocytic Vesicle to Bos taurus, Cell, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 18258
type: UnificationXref
id: CHEBI:18258
db: ChEBI

Transport7976
type: Transport
participant stoichiometry: Compound/PW C000169 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000169 Extracellular Space/Stoichiometry/1.0
right: Thyroxine
spontaneous: false
left: Thyroxine
name: Thyroxine (→) Transport: Bos taurus, Cell, Exocytic Vesicle to Bos taurus, Cell, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport7975
type: Transport
participant stoichiometry: Compound/PW C000169 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000169 Cytosol/Stoichiometry/1.0
right: Thyroxine
spontaneous: false
left: Thyroxine
name: Thyroxine (→) Transport: Bos taurus, Cell, Cytosol to Bos taurus, Cell, Exocytic Vesicle
conversion direction: LEFT_TO_RIGHT

Transport7974
type: Transport
participant stoichiometry: Compound/PW C000169 Endocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000169 Cytosol/Stoichiometry/1.0
right: Thyroxine
spontaneous: false
left: Thyroxine
name: Thyroxine (→) Transport: Bos taurus, Cell, Endocytic Vesicle to Bos taurus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Thyroglobulin
type: Protein
cellular location: Nucleus
entity reference: Thyroglobulin
name: SubPathwayOutput

Transport7973
type: Transport
participant stoichiometry: Protein/17630 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Protein/17630 Cytosol/Stoichiometry/1.0
right: Thyroglobulin
spontaneous: false
left: Thyroglobulin
name: [thyroglobulin]-thyroxine (→) Transport: Bos taurus, Extracellular Space to Bos taurus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Endocytic Vesicle
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0030139

Transport7972
type: Transport
participant stoichiometry: Protein/17630 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Protein/17630 Cytosol/Stoichiometry/1.0
right: Thyroglobulin
spontaneous: false
left: Thyroglobulin
name: [thyroglobulin]-3,5,3'-triiodo-L-thyronine (→) Transport: Bos taurus, Extracellular Space to Bos taurus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Compound/PW C000169 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thyroxine
stoichiometric coefficient: 1.0

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Protein/17638 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cytochrome b-245 heavy chain
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/CAS 6893-02-3
type: UnificationXref
id: 6893-02-3
db: CAS

Exocytic Vesicle
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0070382

Unknown
type: Protein
entity reference: Unknown

Compound/PW C007784 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Iodide
stoichiometric coefficient: 1.0

Liothyronine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Liothyronine

Transport7982
type: Transport
participant stoichiometry: Protein/17630 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Protein/17630 Cytosol/Stoichiometry/1.0
right: Thyroglobulin
spontaneous: false
left: Thyroglobulin
name: Thyroglobulin with L-Tyrosine (←) Transport: Bos taurus, Cell, Cytosol to Bos taurus, Cell, Exocytic Vesicle
conversion direction: LEFT_TO_RIGHT

Transport7981
type: Transport
participant stoichiometry: Protein/17630 Nucleus/Stoichiometry/1.0
participant stoichiometry: Protein/17630 Exocytic Vesicle/Stoichiometry/1.0
right: Thyroglobulin
spontaneous: false
left: Thyroglobulin
name: Thyroglobulin with L-Tyrosine (←) Transport: Bos taurus, Cell, Exocytic Vesicle to Bos taurus, Cell, Nucleus
conversion direction: LEFT_TO_RIGHT

Transport7980
type: Transport
participant stoichiometry: Protein/17630 Endocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Protein/17630 Cytosol/Stoichiometry/1.0
right: Thyroglobulin
spontaneous: false
left: Thyroglobulin
name: Thyroglobulin with L-Tyrosine (←) Transport: Bos taurus, Cell, Endocytic Vesicle to Bos taurus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C01829
type: UnificationXref
id: C01829
db: KEGG Compound

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Compound/PW C000458/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Reference/ChemSpider 5614
type: UnificationXref
id: 5614
db: ChemSpider

Thyroglobulin
type: Protein
cellular location: Endocytic Vesicle
entity reference: Thyroglobulin

Reference/PubChem-compound 30165
type: UnificationXref
id: 30165
db: PubChem-compound

Reference/ChEBI CHEBI 16240
type: UnificationXref
id: CHEBI:16240
db: ChEBI

Reference/UniProt A4IF96
type: UnificationXref
id: A4IF96
db: UniProt

ChemicalStructure/PW C000169
type: ChemicalStructure
structure format: SMILES

Liothyronine
type: SmallMolecule
cellular location: Endocytic Vesicle
entity reference: Liothyronine

Transport7971
type: Transport
participant stoichiometry: Compound/PW C007784 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007784 Cytosol/Stoichiometry/1.0
right: Iodide
spontaneous: false
left: Iodide
name: Iodide (→) Transport: Bos taurus, Cell, Cytosol to Bos taurus, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Protein/17630 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thyroglobulin
stoichiometric coefficient: 1.0

Transport7970
type: Transport
participant stoichiometry: Compound/PW C000458/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007784 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007784/Stoichiometry/1.0
right: Iodide
right: Sodium
spontaneous: false
left: Iodide
left: Sodium
name: Sodium (→), Iodide (→) Transport: Bos taurus, Blood Vessel to Bos taurus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Compound/PW C000181 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Liothyronine
stoichiometric coefficient: 1.0

Iodide
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Iodide

Reference/SMPDB SMP0087269
type: UnificationXref
id: SMP0087269
db: SMPDB

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Compound/PW C001783 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen peroxide
stoichiometric coefficient: 1.0

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Hydrogen peroxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen peroxide

Sodium
type: SmallMolecule
cellular location: Cytosol
entity reference: Sodium

Compound/PW C000458 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Thyroxine
type: SmallMolecule
cellular location: Endocytic Vesicle
entity reference: Thyroxine

Thyroxine
type: SmallMolecule
cellular location: Cytosol
entity reference: Thyroxine

Compound/PW C000181 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Liothyronine
stoichiometric coefficient: 1.0

Iodide
type: SmallMoleculeReference
xref: Reference/ChemSpider 28015
xref: Reference/HMDB HMDB0012238
xref: Reference/BioCyc CPD-387
xref: Reference/KEGG Compound C00708
xref: Reference/PubChem-compound 30165
xref: Reference/ChEBI CHEBI 16382
xref: Reference/CAS 20461-54-5
chemical formula: I
molecular weight: 126.904465
structure: ChemicalStructure/PW C007784

Lactoperoxidase
type: Protein
cellular location: Cytosol
entity reference: Lactoperoxidase

Protein/17630 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Thyroglobulin
stoichiometric coefficient: 2.0

Reference/UniProt A5PK68
type: UnificationXref
id: A5PK68
db: UniProt

Compound/PW C007784 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Iodide
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Liothyronine
type: SmallMolecule
cellular location: Exocytic Vesicle
entity reference: Liothyronine

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Transport7983
type: Transport
participant stoichiometry: Protein/17630 Endocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Protein/17630 Cytosol/Stoichiometry/1.0
right: Thyroglobulin
spontaneous: false
left: Thyroglobulin
name: Thyroglobulin with L-Tyrosine (↔) Transport: Bos taurus, Cell, Endocytic Vesicle to Bos taurus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/KEGG Compound C01330
type: UnificationXref
id: C01330
db: KEGG Compound

Reference/PubChem-compound 5920
type: UnificationXref
id: 5920
db: PubChem-compound

Reference/HMDB HMDB0000588
type: UnificationXref
id: HMDB0000588
db: HMDB

Protein/17630 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thyroglobulin
stoichiometric coefficient: 1.0

SubPathwayInteraction108399
type: Interaction
name: SubPathwayReaction
name: SubPathway108399Reaction
participant: Thyroglobulin

Compound/PW C000169 Exocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thyroxine
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005634
type: UnificationXref
id: GO:0005634
db: GENE ONTOLOGY

Iodide
type: SmallMolecule
cellular location: Cytosol
entity reference: Iodide

Compound/PW C000169 Endocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thyroxine
stoichiometric coefficient: 1.0

Reference/BioCyc LIOTHYRONINE
type: UnificationXref
id: LIOTHYRONINE
db: BioCyc

Sodium-coupled monocarboxylate transporter 2
type: Protein
entity reference: Sodium-coupled monocarboxylate transporter 2

Thyroxine
type: SmallMoleculeReference
xref: Reference/CAS 51-48-9
xref: Reference/PubChem-compound 25201348
xref: Reference/HMDB HMDB0000248
xref: Reference/ChemSpider 5614
xref: Reference/KEGG Compound C01829
xref: Reference/BioCyc L-THYROXINE
xref: Reference/ChEBI CHEBI 18332
chemical formula: C15H11I4NO4
molecular weight: 776.6867
structure: ChemicalStructure/PW C000169

Liothyronine
type: SmallMolecule
cellular location: Cytosol
entity reference: Liothyronine

Reference/PathWhiz PW088288
type: UnificationXref
id: PW088288
db: PathWhiz

Reference/UniProt A7MBD8
type: UnificationXref
id: A7MBD8
db: UniProt

Thyroxine
type: SmallMolecule
cellular location: Exocytic Vesicle
entity reference: Thyroxine

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/ChEBI CHEBI 18332
type: UnificationXref
id: CHEBI:18332
db: ChEBI

Reference/CAS 51-48-9
type: UnificationXref
id: 51-48-9
db: CAS

Hydrogen peroxide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003125
xref: Reference/PubChem-compound 784
xref: Reference/ChemSpider 763
xref: Reference/CAS 7722-84-1
xref: Reference/BioCyc HYDROGEN-PEROXIDE
xref: Reference/ChEBI CHEBI 16240
xref: Reference/KEGG Compound C00027
chemical formula: H2O2
molecular weight: 34.005478
structure: ChemicalStructure/PW C001783

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Iodide
type: SmallMolecule
entity reference: Iodide

ChemicalStructure/PW C007784
type: ChemicalStructure
structure format: SMILES
structure data: [I-]

Protein/17630 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thyroglobulin
stoichiometric coefficient: 1.0

Reference/ChemSpider 5707
type: UnificationXref
id: 5707
db: ChemSpider

Compound/PW C000181 Exocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: Liothyronine
stoichiometric coefficient: 1.0

Thyroxine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Thyroxine

Nucleus
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005634

Sodium-coupled monocarboxylate transporter 2
type: ProteinReference
xref: Reference/UniProt A7MBD8

Sodium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000588
xref: Reference/PubChem-compound 923
xref: Reference/KEGG Compound C01330
xref: Reference/ChEBI CHEBI 29101
xref: Reference/ChemSpider 899
xref: Reference/CAS 17341-25-2
chemical formula: Na
molecular weight: 22.989769
structure: ChemicalStructure/PW C000458

Thyroglobulin
type: Protein
cellular location: Exocytic Vesicle
entity reference: Thyroglobulin

Thyroid Hormone Synthesis
type: Pathway
pathway order: PathwayTransport/2113634
pathway order: PathwayTransport/2113624
pathway order: PathwayTransport/2113635
pathway order: PathwayTransport/2113625
pathway order: PathwayTransport/2113636
pathway order: PathwayTransport/2113626
pathway order: PathwayTransport/2113637
pathway order: PathwaySubPathway/108399
pathway order: PathwayEnzymeReaction/2113621
pathway order: PathwayTransport/2113627
pathway order: PathwayEnzymeReaction/2113622
pathway order: PathwayTransport/2113628
pathway order: PathwayTransport/2113629
pathway order: PathwayEnzymeReaction/2113620
pathway order: PathwayEnzymeReaction/2113623
pathway order: PathwayTransport/2113630
pathway order: PathwayTransport/2113631
pathway order: PathwayTransport/2113632
pathway order: PathwayTransport/2113633
pathway component: Transport7979
pathway component: Transport7978
pathway component: ReactionCatalysis168759
pathway component: Transport7977
pathway component: Transport7976
pathway component: Transport7975
pathway component: TransportCatalysis1044
pathway component: Transport7974
pathway component: Transport7973
pathway component: Transport7972
pathway component: Thyroglobulin secretion
pathway component: Transport7982
pathway component: Transport7981
pathway component: TransportCatalysis1043
pathway component: Transport7980
pathway component: 1.11.1.8
pathway component: Transport7983
pathway component: ReactionCatalysis168762
pathway component: ReactionCatalysis168761
pathway component: ReactionCatalysis168760
pathway component: Transport7971
pathway component: Transport7970
xref: Reference/SMPDB SMP0087269
xref: Reference/PathWhiz PW088288
organism: Bos taurus

ReactionCatalysis168762
type: Catalysis
controller: Thyroid peroxidase
controlled: 1.11.1.8
control type: ACTIVATION

ReactionCatalysis168761
type: Catalysis
controller: Thyroid peroxidase
controlled: 1.11.1.8
control type: ACTIVATION

Thyroid peroxidase
type: Complex
component stoichiometry: Protein/17644 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/17636 Cytosol/Stoichiometry/2.0
component stoichiometry: Protein/17638 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Cytochrome b-245 light chain
component: Lactoperoxidase
component: Cytochrome b-245 heavy chain

Reference/KEGG Compound C00027
type: UnificationXref
id: C00027
db: KEGG Compound

ReactionCatalysis168760
type: Catalysis
controller: Thyroid peroxidase
controlled: 1.11.1.8
control type: ACTIVATION

Unknown
type: ProteinReference

Compound/PW C007784/Stoichiometry/1.0
type: Stoichiometry
physical entity: Iodide
stoichiometric coefficient: 1.0

Liothyronine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000265
xref: Reference/CAS 6893-02-3
xref: Reference/ChEBI CHEBI 18258
xref: Reference/BioCyc LIOTHYRONINE
xref: Reference/PubChem-compound 5920
xref: Reference/ChemSpider 5707
xref: Reference/KEGG Compound C02465
chemical formula: C15H12I3NO4
molecular weight: 650.79004
structure: ChemicalStructure/PW C000181

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/HMDB HMDB0000248
type: UnificationXref
id: HMDB0000248
db: HMDB

Protein/17630 Exocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thyroglobulin
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00708
type: UnificationXref
id: C00708
db: KEGG Compound

Reference/ChEBI CHEBI 29101
type: UnificationXref
id: CHEBI:29101
db: ChEBI