Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Reference/PubChem-compound 439161
type: UnificationXref
id: 439161
db: PubChem-compound

Compound/PW C000691 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Xylulose 5-phosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 96860
type: UnificationXref
id: 96860
db: ChemSpider

Compound/PW C000500 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamine
stoichiometric coefficient: 1.0

ReactionCatalysis135838
type: Catalysis
controller: Glutamate dehydrogenase 1, mitochondrial
controlled: 1.4.1.3
control type: ACTIVATION

Reference/ChEBI CHEBI 30797
type: UnificationXref
id: CHEBI:30797
db: ChEBI

Reference/HMDB HMDB0001068
type: UnificationXref
id: HMDB0001068
db: HMDB

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

Compound/PW C000125 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isocitric acid
stoichiometric coefficient: 1.0

Mitochondrial pyruvate carrier 1
type: ProteinReference
xref: Reference/UniProt Q3ZCG2

Compound/PW C000063 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Citric acid
stoichiometric coefficient: 1.0

Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q5UAB3
organism: Bos taurus

Reference/ChemSpider 50
type: UnificationXref
id: 50
db: ChemSpider

Reference/TAXONOMY 9913
type: UnificationXref
id: 9913
db: TAXONOMY

Fructose 1,6-bisphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001058
xref: Reference/BioCyc FRUCTOSE-16-DIPHOSPHATE
xref: Reference/CAS 488-69-7
xref: Reference/ChEBI CHEBI 16905
xref: Reference/ChemSpider 393165
xref: Reference/KEGG Compound C00354
xref: Reference/PubChem-compound 445557
chemical formula: C6H14O12P2
molecular weight: 339.99606
structure: ChemicalStructure/PW C000833

D-Ribulose 5-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Ribulose 5-phosphate

Compound/PW C000881 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 6-Phosphonoglucono-D-lactone
stoichiometric coefficient: 1.0

Reference/BioCyc OXALACETIC ACID
type: UnificationXref
id: OXALACETIC_ACID
db: BioCyc

Transketolase
type: Complex
component stoichiometry: Protein/17154 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Transketolase

Protein/16155 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Pyruvate kinase
stoichiometric coefficient: 2.0

Reference/HMDB HMDB0001072
type: UnificationXref
id: HMDB0001072
db: HMDB

Compound/PW C000479 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Ribulose 5-phosphate
stoichiometric coefficient: 1.0

Aconitate hydratase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q3SZZ1
organism: Bos taurus

Reference/HMDB HMDB0003498
type: UnificationXref
id: HMDB0003498
db: HMDB

Reference/ChemSpider 5743
type: UnificationXref
id: 5743
db: ChemSpider

Reference/ChEBI CHEBI 16238
type: UnificationXref
id: CHEBI:16238
db: ChEBI

Reference/ChemSpider 5746
type: UnificationXref
id: 5746
db: ChemSpider

Reference/BioCyc HCO3
type: UnificationXref
id: HCO3
db: BioCyc

Reference/ChEBI CHEBI 15380
type: UnificationXref
id: CHEBI:15380
db: ChEBI

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

NADH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADH

Succinyl-CoA
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00091
xref: Reference/CAS 604-98-8
xref: Reference/ChemSpider 388307
xref: Reference/PubChem-compound 439161
xref: Reference/ChEBI CHEBI 15380
xref: Reference/BioCyc 3-METHYLBENZYLSUCCINYL-COA
xref: Reference/HMDB HMDB0001022
chemical formula: C25H40N7O19P3S
molecular weight: 867.1312
structure: ChemicalStructure/PW C000808

Reference/PubChem-compound 439184
type: UnificationXref
id: 439184
db: PubChem-compound

D-Ribose 5-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Ribose 5-phosphate

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Compound/PW C001034 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/UniProt P41563
type: UnificationXref
id: P41563
db: UniProt

ChemicalStructure/PW C001083
type: ChemicalStructure
structure format: SMILES

Reference/CAS 97-67-6
type: UnificationXref
id: 97-67-6
db: CAS

β-D-Glucose 6-phosphate
type: SmallMoleculeReference
xref: Reference/ChemSpider 388538
xref: Reference/KEGG Compound C01172
xref: Reference/ChEBI CHEBI 17719
xref: Reference/HMDB HMDB0003498
xref: Reference/PubChem-compound 439427
chemical formula: C6H13O9P
molecular weight: 260.02972
structure: ChemicalStructure/PW C001906

D-Sedoheptulose 7-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Sedoheptulose 7-phosphate

Reference/CAS 2646-35-7
type: UnificationXref
id: 2646-35-7
db: CAS

ReactionCatalysis135823
type: Catalysis
controller: Glutaminase 2
controlled: 3.5.1.2
control type: ACTIVATION

FAD
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: FAD

Compound/PW C001083 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glucose 6-phosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

Compound/PW C000063 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Citric acid
stoichiometric coefficient: 1.0

Fumarate hydratase
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Fumarate hydratase

Reference/ChEBI CHEBI 30769
type: UnificationXref
id: CHEBI:30769
db: ChEBI

Reference/PubChem-compound 439167
type: UnificationXref
id: 439167
db: PubChem-compound

Compound/PW C000125 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isocitric acid
stoichiometric coefficient: 1.0

D-Glyceraldehyde 3-phosphate
type: SmallMoleculeReference
xref: Reference/BioCyc GAP
xref: Reference/ChEBI CHEBI 17138
xref: Reference/HMDB HMDB0001112
xref: Reference/ChemSpider 709
xref: Reference/KEGG Compound C00661
xref: Reference/PubChem-compound 729
xref: Reference/CAS 591-59-3
chemical formula: C3H7O6P
molecular weight: 169.99803
structure: ChemicalStructure/PW C000869

Reference/CAS 138-08-9
type: UnificationXref
id: 138-08-9
db: CAS

ChemicalStructure/PW C000808
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 1161
type: UnificationXref
id: 1161
db: ChemSpider

Reference/KEGG Compound C00231
type: UnificationXref
id: C00231
db: KEGG Compound

Glutaminase 2
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Glutaminase 2

Reference/KEGG Compound C00236
type: UnificationXref
id: C00236
db: KEGG Compound

Compound/PW C001144 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Compound/PW C000122 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Lactic acid
stoichiometric coefficient: 1.0

Reference/BioCyc SUC
type: UnificationXref
id: SUC
db: BioCyc

Reference/UniProt Q3ZCB1
type: UnificationXref
id: Q3ZCB1
db: UniProt

Transketolase
type: ProteinReference
xref: Reference/UniProt Q6B855
organism: Bos taurus

Reference/CAS 7664-38-2
type: UnificationXref
id: 7664-38-2
db: CAS

Transaldolase
type: ProteinReference
xref: Reference/UniProt Q2TBL6
organism: Bos taurus

Reference/UniProt Q0V8L1
type: UnificationXref
id: Q0V8L1
db: UniProt

Reference/UniProt Q0P576
type: UnificationXref
id: Q0P576
db: UniProt

Compound/PW C000035 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonia
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

ChemicalStructure/PW C001906
type: ChemicalStructure
structure format: SMILES

Protein/17159 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Transaldolase
stoichiometric coefficient: 2.0

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Fructose 6-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Fructose 6-phosphate

Reference/PubChem-compound 439190
type: UnificationXref
id: 439190
db: PubChem-compound

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

NADPH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADPH

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Coenzyme A
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Coenzyme A

6-Phosphonoglucono-D-lactone
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001127
xref: Reference/PubChem-compound 439452
xref: Reference/ChemSpider 388559
xref: Reference/ChEBI CHEBI 16938
xref: Reference/KEGG Compound C01236
xref: Reference/CAS 2641-81-8
xref: Reference/BioCyc D-6-P-GLUCONO-DELTA-LACTONE
chemical formula: C6H11O9P
molecular weight: 258.01407
structure: ChemicalStructure/PW C000881

6-phosphofructokinase, liver type
type: Complex
component stoichiometry: Protein/15626 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: ATP-dependent 6-phosphofructokinase, liver type

Reference/KEGG Compound C11378
type: UnificationXref
id: C11378
db: KEGG Compound

Coenzyme Q10
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001072
xref: Reference/BioCyc UBIQUINONE-10
xref: Reference/PubChem-compound 5281915
xref: Reference/ChemSpider 4445197
xref: Reference/CAS 303-98-0
xref: Reference/KEGG Compound C11378
xref: Reference/ChEBI CHEBI 46245
chemical formula: C59H90O4
molecular weight: 862.6839
structure: ChemicalStructure/PW C000846

Reference/ChemSpider 388411
type: UnificationXref
id: 388411
db: ChemSpider

D-Sedoheptulose 7-phosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001068
xref: Reference/ChemSpider 17216052
xref: Reference/BioCyc D-SEDOHEPTULOSE-7-P
xref: Reference/PubChem-compound 22833559
xref: Reference/ChEBI CHEBI 15721
xref: Reference/KEGG Compound C00281
xref: Reference/CAS 2646-35-7
chemical formula: C7H15O10P
molecular weight: 290.04028
structure: ChemicalStructure/PW C000843

Compound/PW C001316 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Glucose-6-phosphate isomerase
type: Complex
component stoichiometry: Protein/16125 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Glucose-6-phosphate isomerase

Reference/PubChem-compound 107689
type: UnificationXref
id: 107689
db: PubChem-compound

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/BioCyc FRUCTOSE-6P
type: UnificationXref
id: FRUCTOSE-6P
db: BioCyc

ATP-dependent 6-phosphofructokinase, liver type
type: Protein
cellular location: Cytosol
entity reference: ATP-dependent 6-phosphofructokinase, liver type

Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

Reference/KEGG Compound C00016
type: UnificationXref
id: C00016
db: KEGG Compound

Reference/KEGG Compound C00014
type: UnificationXref
id: C00014
db: KEGG Compound

Reference/ChEBI CHEBI 17363
type: UnificationXref
id: CHEBI:17363
db: ChEBI

1.1.1.42
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000134 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000125 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
right: Oxoglutaric acid
right: Carbon dioxide
right: NADPH
spontaneous: false
EC number: 1.1.1.42
left: Isocitric acid
left: NADP
name: Isocitric acid + NADP → Carbon dioxide + NADPH + Oxoglutaric acid
conversion direction: LEFT_TO_RIGHT

1.1.1.49
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001906 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000881 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
right: 6-Phosphonoglucono-D-lactone
right: Hydrogen Ion
right: NADPH
spontaneous: false
EC number: 1.1.1.49
left: β-D-Glucose 6-phosphate
left: NADP
name: NADP + β-D-Glucose 6-phosphate ↔ 6-Phosphonoglucono-D-lactone + Hydrogen Ion + NADPH
conversion direction: REVERSIBLE

3.1.1.31
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001015 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000881 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001051 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: Hydrogen
right: 6-Phosphogluconic acid
spontaneous: false
EC number: 3.1.1.31
left: 6-Phosphonoglucono-D-lactone
left: Water
name: 6-Phosphonoglucono-D-lactone + Water → 6-Phosphogluconic acid + Hydrogen
conversion direction: LEFT_TO_RIGHT

4.2.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000063 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000125 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000125 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000063 Cytosol/Stoichiometry/1.0
right: Isocitric acid
spontaneous: false
EC number: 4.2.1.3
left: Citric acid
name: Citric acid → Isocitric acid
conversion direction: LEFT_TO_RIGHT

Pyruvate carboxylase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q866R1
organism: Bos taurus

Isocitrate dehydrogenase [NADP] cytoplasmic
type: Protein
cellular location: Cytosol
entity reference: Isocitrate dehydrogenase [NADP] cytoplasmic

Reference/ChEBI CHEBI 17138
type: UnificationXref
id: CHEBI:17138
db: ChEBI

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Phosphate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Phosphate

Reference/KEGG Compound C00022
type: UnificationXref
id: C00022
db: KEGG Compound

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/KEGG Compound C01352
type: UnificationXref
id: C01352
db: KEGG Compound

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/KEGG Compound C00026
type: UnificationXref
id: C00026
db: KEGG Compound

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

Reference/ChEBI CHEBI 26078
type: UnificationXref
id: CHEBI:26078
db: ChEBI

Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q9T2T6
organism: Bos taurus

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q3T189
organism: Bos taurus

Glucose-6-phosphate 1-dehydrogenase
type: Protein
cellular location: Cytosol
entity reference: Glucose-6-phosphate 1-dehydrogenase

L-Glutamic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: L-Glutamic acid

NADP
type: SmallMolecule
cellular location: Cytosol
entity reference: NADP

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q9TUY8
organism: Bos taurus

Reference/ChEBI CHEBI 48928
type: UnificationXref
id: CHEBI:48928
db: ChEBI

Protein/15676 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Glyceraldehyde-3-phosphate dehydrogenase
stoichiometric coefficient: 4.0

Reference/PubChem-compound 769
type: UnificationXref
id: 769
db: PubChem-compound

ChemicalStructure/PW C001019
type: ChemicalStructure
structure format: SMILES
structure data: O[C@H](COP(O)(O)=O)[C@@H](O)C=O

Reference/KEGG Compound C00031
type: UnificationXref
id: C00031
db: KEGG Compound

Reference/UniProt Q3SYW4
type: UnificationXref
id: Q3SYW4
db: UniProt

Reference/KEGG Compound C00279
type: UnificationXref
id: C00279
db: KEGG Compound

Reference/KEGG Compound C00036
type: UnificationXref
id: C00036
db: KEGG Compound

Reference/ChEBI CHEBI 18276
type: UnificationXref
id: CHEBI:18276
db: ChEBI

Reference/KEGG Compound C00035
type: UnificationXref
id: C00035
db: KEGG Compound

Protein/17132 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Glucose-6-phosphate 1-dehydrogenase
stoichiometric coefficient: 4.0

Reference/HMDB HMDB0000134
type: UnificationXref
id: HMDB0000134
db: HMDB

ChemicalStructure/PW C000174
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(O)=O

Compound/PW C000500 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamine
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00282
type: UnificationXref
id: C00282
db: KEGG Compound

Reference/KEGG Compound C00281
type: UnificationXref
id: C00281
db: KEGG Compound

Compound/PW C000463 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen carbonate
stoichiometric coefficient: 1.0

Protein/14899 Mitochondrial Matrix/Stoichiometry/4.0
type: Stoichiometry
physical entity: Fumarate hydratase
stoichiometric coefficient: 4.0

Compound/PW C001019 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Erythrose 4-phosphate
stoichiometric coefficient: 1.0

Transport7940
type: Transport
participant stoichiometry: Compound/PW C000063 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000063 Cytosol/Stoichiometry/1.0
right: Citric acid
spontaneous: false
left: Citric acid
name: Citric acid (←) Transport: Bos taurus, Cell, Cytosol to Bos taurus, Cell, Mitochondrial Matrix
conversion direction: LEFT_TO_RIGHT

D-Erythrose 4-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Erythrose 4-phosphate

Reference/KEGG Compound C00044
type: UnificationXref
id: C00044
db: KEGG Compound

Reference/UniProt Q3SYV2
type: UnificationXref
id: Q3SYV2
db: UniProt

Reference/KEGG Compound C00042
type: UnificationXref
id: C00042
db: KEGG Compound

L-Glutamine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Glutamine

Reference/ChemSpider 648
type: UnificationXref
id: 648
db: ChemSpider

Compound/PW C000932 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: FADH
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00288
type: UnificationXref
id: C00288
db: KEGG Compound

Reference/CAS 56-85-9
type: UnificationXref
id: 56-85-9
db: CAS

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Reference/CAS 604-98-8
type: UnificationXref
id: 604-98-8
db: CAS

6-phosphogluconate dehydrogenase, decarboxylating
type: Complex
component stoichiometry: Protein/17664 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: 6-phosphogluconate dehydrogenase, decarboxylating

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

Compound/PW C000134 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxoglutaric acid
stoichiometric coefficient: 1.0

Succinyl-CoA ligase
type: Complex
component stoichiometry: Protein/14890 Mitochondrial Matrix/Stoichiometry/1.0
component stoichiometry: Protein/14887 Mitochondrial Matrix/Stoichiometry/1.0
cellular location: Mitochondrial Matrix
component: Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
component: Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial

Reference/HMDB HMDB0001473
type: UnificationXref
id: HMDB0001473
db: HMDB

ChemicalStructure/PW C000180
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C(=C)OP(O)(O)=O

3-Phosphoglyceric acid
type: SmallMoleculeReference
xref: Reference/BioCyc G3P
xref: Reference/PubChem-compound 724
xref: Reference/ChEBI CHEBI 17050
xref: Reference/ChemSpider 704
xref: Reference/CAS 820-11-1
xref: Reference/KEGG Compound C00597
xref: Reference/HMDB HMDB0000807
chemical formula: C3H7O7P
molecular weight: 185.99294
structure: ChemicalStructure/PW C000644

Reference/BioCyc FUM
type: UnificationXref
id: FUM
db: BioCyc

ChemicalStructure/PW C000148
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC(=O)C(O)=O

Reference/ChEBI CHEBI 4170
type: UnificationXref
id: CHEBI:4170
db: ChEBI

Reference/ChEBI CHEBI 18012
type: UnificationXref
id: CHEBI:18012
db: ChEBI

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Reference/HMDB HMDB0000156
type: UnificationXref
id: HMDB0000156
db: HMDB

Compound/PW C000095 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001248
type: UnificationXref
id: HMDB0001248
db: HMDB

Glucose-6-phosphate 1-dehydrogenase
type: ProteinReference
xref: Reference/UniProt F1MMK2
organism: Bos taurus

Pyruvic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Pyruvic acid

6-phosphogluconolactonase
type: ProteinReference
xref: Reference/UniProt Q2TBQ8
organism: Bos taurus

Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Ribose-5-phosphate isomerase
type: ProteinReference
xref: Reference/UniProt Q3T186
organism: Bos taurus

Compound/PW C001015 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 6-Phosphogluconic acid
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Phosphoric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphoric acid

Reference/BioCyc DPG
type: UnificationXref
id: DPG
db: BioCyc

Reference/BioCyc DIHYDROXY-ACETONE-PHOSPHATE
type: UnificationXref
id: DIHYDROXY-ACETONE-PHOSPHATE
db: BioCyc

ChemicalStructure/PW C001006
type: ChemicalStructure
structure format: SMILES
structure data: COC1=C(O)C(C)=C(C\C=C(/C)CCC=C(C)C)C(O)=C1OC

Reference/KEGG Compound C00064
type: UnificationXref
id: C00064
db: KEGG Compound

Compound/PW C000077 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glucose
stoichiometric coefficient: 1.0

NAD
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: NAD

ChemicalStructure/PW C000164
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)C(O)=O

Reference/ChemSpider 663
type: UnificationXref
id: 663
db: ChemSpider

Reference/KEGG Compound C00074
type: UnificationXref
id: C00074
db: KEGG Compound

ChemicalStructure/PW C001015
type: ChemicalStructure
structure format: SMILES

3-Phosphoglyceric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: 3-Phosphoglyceric acid

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Compound/PW C000808 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinyl-CoA
stoichiometric coefficient: 1.0

Reference/PubChem-compound 724
type: UnificationXref
id: 724
db: PubChem-compound

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Transport7915
type: Transport
participant stoichiometry: Compound/PW C000500 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500 Cytoplasm/Stoichiometry/1.0
right: L-Glutamine
spontaneous: false
left: L-Glutamine
name: L-Glutamine (→) Transport: Bos taurus, Extracellular Space to Bos taurus, Cell, Cytoplasm
conversion direction: LEFT_TO_RIGHT

Glyceraldehyde-3-phosphate dehydrogenase
type: Protein
cellular location: Cytosol
entity reference: Glyceraldehyde-3-phosphate dehydrogenase

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reference/KEGG Compound C00085
type: UnificationXref
id: C00085
db: KEGG Compound

Reference/KEGG Compound C01172
type: UnificationXref
id: C01172
db: KEGG Compound

Reference/PubChem-compound 729
type: UnificationXref
id: 729
db: PubChem-compound

Pyruvate kinase PKLR
type: Complex
component stoichiometry: Protein/16155 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Pyruvate kinase
name: SubPathwayInhibition

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Adenosine diphosphate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Adenosine diphosphate

Reference/HMDB HMDB0001022
type: UnificationXref
id: HMDB0001022
db: HMDB

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/BioCyc PYRUVATE
type: UnificationXref
id: PYRUVATE
db: BioCyc

Reference/BioCyc QH2
type: UnificationXref
id: QH2
db: BioCyc

D-Ribulose 5-phosphate
type: SmallMoleculeReference
xref: Reference/CAS 4151-19-3
xref: Reference/BioCyc RIBULOSE-5P
xref: Reference/KEGG Compound C00199
xref: Reference/PubChem-compound 439184
xref: Reference/HMDB HMDB0000618
xref: Reference/ChEBI CHEBI 17363
chemical formula: C5H11O8P
molecular weight: 230.01915
structure: ChemicalStructure/PW C000479

Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00092
type: UnificationXref
id: C00092
db: KEGG Compound

Reference/KEGG Compound C00091
type: UnificationXref
id: C00091
db: KEGG Compound

Reference/BioCyc G3P
type: UnificationXref
id: G3P
db: BioCyc

Compound/PW C001006 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: QH2
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 4167
type: UnificationXref
id: CHEBI:4167
db: ChEBI

Reference/HMDB HMDB0001270
type: UnificationXref
id: HMDB0001270
db: HMDB

Protein/15098 Mitochondrial Matrix/Stoichiometry/6.0
type: Stoichiometry
physical entity: Glutamate dehydrogenase 1, mitochondrial
stoichiometric coefficient: 6.0

Reference/HMDB HMDB0001273
type: UnificationXref
id: HMDB0001273
db: HMDB

Isocitric acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Isocitric acid

L-Glutamine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: L-Glutamine

Compound/PW C000869 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glyceraldehyde 3-phosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000190
type: UnificationXref
id: HMDB0000190
db: HMDB

Succinic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Succinic acid

Reference/BioCyc XYLULOSE-5-PHOSPHATE
type: UnificationXref
id: XYLULOSE-5-PHOSPHATE
db: BioCyc

Coenzyme Q10
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Coenzyme Q10

Reference/ChEBI CHEBI 18050
type: UnificationXref
id: CHEBI:18050
db: ChEBI

Reference/BioCyc FADH2
type: UnificationXref
id: FADH2
db: BioCyc

Reference/HMDB HMDB0000193
type: UnificationXref
id: HMDB0000193
db: HMDB

Reference/ChemSpider 393165
type: UnificationXref
id: 393165
db: ChemSpider

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Xylulose 5-phosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000868
xref: Reference/KEGG Compound C00231
xref: Reference/BioCyc XYLULOSE-5-PHOSPHATE
xref: Reference/PubChem-compound 439190
xref: Reference/CAS 60802-29-1
xref: Reference/ChEBI CHEBI 16332
xref: Reference/ChemSpider 388330
chemical formula: C5H11O8P
molecular weight: 230.01915
structure: ChemicalStructure/PW C000691

Compound/PW C000122 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Lactic acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 970
type: UnificationXref
id: 970
db: PubChem-compound

Reference/HMDB HMDB0001058
type: UnificationXref
id: HMDB0001058
db: HMDB

Acetyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Acetyl-CoA

Protein/15626 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: ATP-dependent 6-phosphofructokinase, liver type
stoichiometric coefficient: 4.0

Hydrogen carbonate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000595
xref: Reference/ChEBI CHEBI 17544
xref: Reference/PubChem-compound 769
xref: Reference/BioCyc HCO3
xref: Reference/ChemSpider 749
xref: Reference/CAS 71-52-3
xref: Reference/KEGG Compound C00288
chemical formula: CHO3
molecular weight: 60.99257
structure: ChemicalStructure/PW C000463

Reference/UniProt A7MB35
type: UnificationXref
id: A7MB35
db: UniProt

Reference/CAS 820-11-1
type: UnificationXref
id: 820-11-1
db: CAS

ChemicalStructure/PW C001051
type: ChemicalStructure
structure format: SMILES
structure data: [H][H]

Reference/HMDB HMDB0002142
type: UnificationXref
id: HMDB0002142
db: HMDB

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

ReactionCatalysis136127
type: Catalysis
controller: Fructose-bisphosphate aldolase B
controlled: 4.1.2.13
control type: ACTIVATION

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Dihydrolipoyl dehydrogenase
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Dihydrolipoyl dehydrogenase

Reference/PubChem-compound 446013
type: UnificationXref
id: 446013
db: PubChem-compound

Reference/ChEBI CHEBI 15721
type: UnificationXref
id: CHEBI:15721
db: ChEBI

ReactionCatalysis136122
type: Catalysis
controller: 6-phosphofructokinase, liver type
controlled: 2.7.1.11
control type: ACTIVATION

L-Malic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: L-Malic acid

Compound/PW C000174 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinic acid
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000691
type: ChemicalStructure
structure format: SMILES
structure data: OCC(=O)[C@@H](O)[C@H](O)COP(O)(O)=O

Reference/PubChem-compound 21883788
type: UnificationXref
id: 21883788
db: PubChem-compound

Glucose-6-phosphate isomerase
type: Protein
cellular location: Cytosol
entity reference: Glucose-6-phosphate isomerase

Guanosine triphosphate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Guanosine triphosphate

Ammonia
type: SmallMoleculeReference
xref: Reference/BioCyc AMMONIA
xref: Reference/CAS 7664-41-7
xref: Reference/HMDB HMDB0000051
xref: Reference/PubChem-compound 222
xref: Reference/KEGG Compound C00014
xref: Reference/ChEBI CHEBI 16134
xref: Reference/ChemSpider 217
chemical formula: H3N
molecular weight: 17.026548
structure: ChemicalStructure/PW C000035

Compound/PW C000180 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoenolpyruvic acid
stoichiometric coefficient: 1.0

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Unknown
type: Protein
cellular location: Cytosol
entity reference: Unknown

Reference/PubChem-compound 5961
type: UnificationXref
id: 5961
db: PubChem-compound

Protein/17664 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: 6-phosphogluconate dehydrogenase, decarboxylating
stoichiometric coefficient: 2.0

Reference/CAS 643-13-0
type: UnificationXref
id: 643-13-0
db: CAS

Reference/CAS 1981-49-3
type: UnificationXref
id: 1981-49-3
db: CAS

Compound/PW C000148 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxalacetic acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Dihydroxyacetone phosphate
type: SmallMoleculeReference
xref: Reference/BioCyc DIHYDROXY-ACETONE-PHOSPHATE
xref: Reference/PubChem-compound 668
xref: Reference/ChEBI CHEBI 16108
xref: Reference/KEGG Compound C00111
xref: Reference/CAS 57-04-5
xref: Reference/ChemSpider 648
xref: Reference/HMDB HMDB0001473
chemical formula: C3H7O6P
molecular weight: 169.99803
structure: ChemicalStructure/PW C001134

Reference/PubChem-compound 51
type: UnificationXref
id: 51
db: PubChem-compound

FADH
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: FADH

ChemicalStructure/PW C000463
type: ChemicalStructure
structure format: SMILES
structure data: OC([O-])=O

Reference/ChEBI CHEBI 46245
type: UnificationXref
id: CHEBI:46245
db: ChEBI

Reference/HMDB HMDB0001401
type: UnificationXref
id: HMDB0001401
db: HMDB

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: O4P
molecular weight: 94.95342
structure: ChemicalStructure/PW C001104

Reference/PubChem-compound 6830
type: UnificationXref
id: 6830
db: PubChem-compound

Reference/ChEBI CHEBI 15946
type: UnificationXref
id: CHEBI:15946
db: ChEBI

ReactionCatalysis136322
type: Catalysis
controller: Pyruvate kinase PKLR
controlled: 2.7.1.40
control type: ACTIVATION

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

ReactionCatalysis136320
type: Catalysis
controller: Phosphoglycerate mutase 2
controlled: Reaction146183
control type: ACTIVATION

ReactionCatalysis136321
type: Catalysis
controller: Alpha-enolase
controlled: 4.2.1.11
control type: ACTIVATION

Carbon dioxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbon dioxide

ReactionCatalysis136326
type: Catalysis
controller: Unknown
controlled: 1.1.1.27
control type: ACTIVATION

Reference/ChemSpider 217
type: UnificationXref
id: 217
db: ChemSpider

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Neutral amino acid transporter B(0)
type: Protein
entity reference: Neutral amino acid transporter B(0)

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])([O-])=O

Fructose 6-phosphate
type: SmallMoleculeReference
xref: Reference/CAS 643-13-0
xref: Reference/HMDB HMDB0000124
xref: Reference/KEGG Compound C00085
xref: Reference/ChEBI CHEBI 15946
xref: Reference/BioCyc FRUCTOSE-6P
xref: Reference/PubChem-compound 69507
xref: Reference/ChemSpider 62713
chemical formula: C6H13O9P
molecular weight: 260.02972
structure: ChemicalStructure/PW C000079

Reference/ChEBI CHEBI 30915
type: UnificationXref
id: CHEBI:30915
db: ChEBI

Compound/PW C001051 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen
stoichiometric coefficient: 1.0

D-Glucose
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000122
xref: Reference/PubChem-compound 5793
xref: Reference/CAS 2280-44-6
xref: Reference/ChemSpider 5589
xref: Reference/ChEBI CHEBI 4167
xref: Reference/BioCyc GLC
xref: Reference/KEGG Compound C00031
chemical formula: C6H12O6
molecular weight: 180.06339
structure: ChemicalStructure/PW C000077

L-Glutamine
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: L-Glutamine

Transport7986
type: Transport
participant stoichiometry: Compound/PW C000500 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500 Mitochondrial Matrix/Stoichiometry/1.0
right: L-Glutamine
spontaneous: false
left: L-Glutamine
name: L-Glutamine (→) Transport: Bos taurus, Cell, Cytosol to Bos taurus, Cell, Mitochondrial Matrix
conversion direction: LEFT_TO_RIGHT

Transport7985
type: Transport
participant stoichiometry: Compound/PW C000122 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000122 Extracellular Space/Stoichiometry/1.0
right: L-Lactic acid
spontaneous: false
left: L-Lactic acid
name: L-Lactic acid (→) Transport: Bos taurus, Cell, Cytosol to Bos taurus, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport7984
type: Transport
participant stoichiometry: Compound/PW C000077 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000077 Extracellular Space/Stoichiometry/1.0
right: D-Glucose
spontaneous: false
left: D-Glucose
name: D-Glucose (↔) Transport: Bos taurus, Extracellular Space to Bos taurus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/GENE ONTOLOGY GO 0005759
type: UnificationXref
id: GO:0005759
db: GENE ONTOLOGY

Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
type: UnificationXref
id: GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
db: BioCyc

Compound/PW C000164 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 1.0

Fumaric acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000134
xref: Reference/ChemSpider 10197150
xref: Reference/CAS 110-17-8
xref: Reference/PubChem-compound 21883788
xref: Reference/KEGG Compound C00122
xref: Reference/BioCyc FUM
xref: Reference/ChEBI CHEBI 18012
chemical formula: C4H4O4
molecular weight: 116.010956
structure: ChemicalStructure/PW C000088

Reference/ChEBI CHEBI 15741
type: UnificationXref
id: CHEBI:15741
db: ChEBI

Oxoglutaric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxoglutaric acid

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

ReactionCatalysis136306
type: Catalysis
controller: Hexokinase-1
controlled: 2.7.1.1
control type: ACTIVATION

Reference/PubChem-compound 1110
type: UnificationXref
id: 1110
db: PubChem-compound

Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

Pyruvate dehydrogenase complex
type: Complex
component stoichiometry: Protein/14855 Mitochondrial Matrix/Stoichiometry/60.0
component stoichiometry: Protein/14843 Mitochondrial Matrix/Stoichiometry/60.0
component stoichiometry: Protein/14860 Mitochondrial Matrix/Stoichiometry/24.0
component stoichiometry: Protein/14848 Mitochondrial Matrix/Stoichiometry/60.0
cellular location: Mitochondrial Matrix
component: Dihydrolipoyl dehydrogenase
component: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
component: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
component: Pyruvate dehydrogenase protein X component

Reference/HMDB HMDB0001201
type: UnificationXref
id: HMDB0001201
db: HMDB

Reference/HMDB HMDB0000595
type: UnificationXref
id: HMDB0000595
db: HMDB

Reference/PubChem-compound 5958
type: UnificationXref
id: 5958
db: PubChem-compound

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

Transaldolase
type: Complex
component stoichiometry: Protein/17159 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Transaldolase

Reference/UniProt Q9T2T6
type: UnificationXref
id: Q9T2T6
db: UniProt

Reference/ChEBI CHEBI 15996
type: UnificationXref
id: CHEBI:15996
db: ChEBI

ReactionCatalysis136310
type: Catalysis
controller: Glucose-6-phosphate isomerase
controlled: 5.3.1.9
control type: ACTIVATION

ChemicalStructure/PW C000479
type: ChemicalStructure
structure format: SMILES
structure data: OCC(=O)[C@H](O)[C@H](O)COP(O)(O)=O

ReactionCatalysis136317
type: Catalysis
controller: Phosphoglycerate kinase 1
controlled: 2.7.2.3
control type: ACTIVATION

Citrate synthase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Citrate synthase, mitochondrial

Reference/HMDB HMDB0000122
type: UnificationXref
id: HMDB0000122
db: HMDB

Reference/HMDB HMDB0000124
type: UnificationXref
id: HMDB0000124
db: HMDB

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Reference/UniProt A6QPH3
type: UnificationXref
id: A6QPH3
db: UniProt

Pyruvate kinase PKM
type: Complex
component stoichiometry: Protein/16155 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Pyruvate kinase
name: SubPathwayInhibitor

Citric acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 30769
xref: Reference/BioCyc CIT
xref: Reference/HMDB HMDB0000094
xref: Reference/PubChem-compound 19782904
xref: Reference/KEGG Compound C00158
xref: Reference/CAS 77-92-9
xref: Reference/ChemSpider 305
chemical formula: C6H8O7
molecular weight: 192.02701
structure: ChemicalStructure/PW C000063

Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q58DR8
organism: Bos taurus

Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q0V8L1
organism: Bos taurus

ChemicalStructure/PW C000843
type: ChemicalStructure
structure format: SMILES

Compound/PW C000414 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 82615
type: UnificationXref
id: 82615
db: ChemSpider

ChemicalStructure/PW C000846
type: ChemicalStructure
structure format: SMILES
structure data: COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(\C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Reference/ChEBI CHEBI 52742
type: UnificationXref
id: CHEBI:52742
db: ChEBI

Reaction146017
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001441 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000983 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000869 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytosol/Stoichiometry/1.0
right: NADH
right: Glyceric acid 1,3-biphosphate
spontaneous: false
left: NAD
left: Phosphoric acid
left: D-Glyceraldehyde 3-phosphate
name: D-Glyceraldehyde 3-phosphate + NAD + Phosphoric acid ↔ Glyceric acid 1,3-biphosphate + NADH
conversion direction: REVERSIBLE

Mitochondrial Matrix
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005759

D-Glucose
type: SmallMolecule
cellular location: Extracellular Space
entity reference: D-Glucose

Reference/UniProt Q3MHW6
type: UnificationXref
id: Q3MHW6
db: UniProt

Reference/BioCyc D-SEDOHEPTULOSE-7-P
type: UnificationXref
id: D-SEDOHEPTULOSE-7-P
db: BioCyc

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q3MHX5
organism: Bos taurus

Reference/PubChem-compound 222656
type: UnificationXref
id: 222656
db: PubChem-compound

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

Reference/ChemSpider 1078
type: UnificationXref
id: 1078
db: ChemSpider

Reference/UniProt Q2TBQ8
type: UnificationXref
id: Q2TBQ8
db: UniProt

Alpha-enolase
type: Protein
cellular location: Cytosol
entity reference: Alpha-enolase

4.1.2.13
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001134 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000833 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000869 Cytosol/Stoichiometry/1.0
right: Dihydroxyacetone phosphate
right: D-Glyceraldehyde 3-phosphate
spontaneous: false
EC number: 4.1.2.13
left: Fructose 1,6-bisphosphate
name: Fructose 1,6-bisphosphate ↔ D-Glyceraldehyde 3-phosphate + Dihydroxyacetone phosphate
conversion direction: REVERSIBLE

Transaldolase
type: Protein
cellular location: Cytosol
entity reference: Transaldolase

2.7.1.11
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000833 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000079 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: Fructose 1,6-bisphosphate
spontaneous: false
EC number: 2.7.1.11
left: Adenosine triphosphate
left: Fructose 6-phosphate
name: Adenosine triphosphate + Fructose 6-phosphate → Adenosine diphosphate + Fructose 1,6-bisphosphate
conversion direction: LEFT_TO_RIGHT

Fumarate hydratase
type: ProteinReference
xref: Reference/UniProt Q148D3
organism: Bos taurus

Isocitrate dehydrogenase [NADP] cytoplasmic
type: Complex
component stoichiometry: Protein/17672 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Isocitrate dehydrogenase [NADP] cytoplasmic

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

Reference/PubChem-compound 643975
type: UnificationXref
id: 643975
db: PubChem-compound

β-D-Glucose 6-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: β-D-Glucose 6-phosphate

Reference/CAS 127-17-3
type: UnificationXref
id: 127-17-3
db: CAS

Reference/ChEBI CHEBI 17719
type: UnificationXref
id: CHEBI:17719
db: ChEBI

Reference/BioCyc D-6-P-GLUCONO-DELTA-LACTONE
type: UnificationXref
id: D-6-P-GLUCONO-DELTA-LACTONE
db: BioCyc

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Transketolase
type: Protein
cellular location: Cytosol
entity reference: Transketolase

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

Protein/14860 Mitochondrial Matrix/Stoichiometry/24.0
type: Stoichiometry
physical entity: Dihydrolipoyl dehydrogenase
stoichiometric coefficient: 24.0

ChemicalStructure/PW C000833
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc GLC-6-P
type: UnificationXref
id: GLC-6-P
db: BioCyc

Reference/UniProt F1MMK2
type: UnificationXref
id: F1MMK2
db: UniProt

D-Ribose 5-phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00117
xref: Reference/ChEBI CHEBI 52742
xref: Reference/ChemSpider 388313
xref: Reference/HMDB HMDB0001548
xref: Reference/BioCyc RIBOSE-5P
xref: Reference/PubChem-compound 439167
xref: Reference/CAS 4300-28-1
chemical formula: C5H11O8P
molecular weight: 230.01915
structure: ChemicalStructure/PW C001191

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
type: ProteinReference
xref: Reference/UniProt A7MB35
organism: Bos taurus

Reference/CAS 1333-74-0
type: UnificationXref
id: 1333-74-0
db: CAS

Reference/ChEBI CHEBI 17544
type: UnificationXref
id: CHEBI:17544
db: ChEBI

Protein/14868 Mitochondrial Matrix/Stoichiometry/2.0
type: Stoichiometry
physical entity: Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
stoichiometric coefficient: 2.0

Glucose-6-phosphate 1-dehydrogenase
type: Complex
component stoichiometry: Protein/17132 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Glucose-6-phosphate 1-dehydrogenase

Reference/BioCyc 2-KETOGLUTARATE
type: UnificationXref
id: 2-KETOGLUTARATE
db: BioCyc

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

ChemicalStructure/PW C000644
type: ChemicalStructure
structure format: SMILES
structure data: OC(COP(O)(O)=O)C(O)=O

Hexokinase-1
type: Protein
cellular location: Cytosol
entity reference: Hexokinase-1

Protein/14860 Mitochondrial Matrix/Stoichiometry/2.0
type: Stoichiometry
physical entity: Dihydrolipoyl dehydrogenase
stoichiometric coefficient: 2.0

Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial

Reference/CAS 110-15-6
type: UnificationXref
id: 110-15-6
db: CAS

5.3.1.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001906 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001083 Cytosol/Stoichiometry/1.0
right: Glucose 6-phosphate
spontaneous: false
EC number: 5.3.1.9
left: β-D-Glucose 6-phosphate
name: β-D-Glucose 6-phosphate ↔ Glucose 6-phosphate
conversion direction: REVERSIBLE

Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q58CN6
organism: Bos taurus

2.2.1.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001019 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000843 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000869 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000079 Cytosol/Stoichiometry/1.0
right: D-Sedoheptulose 7-phosphate
right: D-Glyceraldehyde 3-phosphate
spontaneous: false
EC number: 2.2.1.2
left: D-Erythrose 4-phosphate
left: Fructose 6-phosphate
name: D-Erythrose 4-phosphate + Fructose 6-phosphate ↔ D-Glyceraldehyde 3-phosphate + D-Sedoheptulose 7-phosphate
conversion direction: REVERSIBLE

2.2.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001191 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000843 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000869 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000691 Cytosol/Stoichiometry/1.0
right: Xylulose 5-phosphate
right: D-Ribose 5-phosphate
spontaneous: false
EC number: 2.2.1.1
left: D-Sedoheptulose 7-phosphate
left: D-Glyceraldehyde 3-phosphate
name: D-Glyceraldehyde 3-phosphate + D-Sedoheptulose 7-phosphate ↔ D-Ribose 5-phosphate + Xylulose 5-phosphate
conversion direction: REVERSIBLE

Compound/PW C000846 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme Q10
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/ChemSpider 6569
type: UnificationXref
id: 6569
db: ChemSpider

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 17552
type: UnificationXref
id: CHEBI:17552
db: ChEBI

Protein/16155 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Pyruvate kinase
stoichiometric coefficient: 4.0

Reference/ChEBI CHEBI 422
type: UnificationXref
id: CHEBI:422
db: ChEBI

Reference/ChEBI CHEBI 30744
type: UnificationXref
id: CHEBI:30744
db: ChEBI

5.3.1.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001191 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000479 Cytosol/Stoichiometry/1.0
right: D-Ribose 5-phosphate
spontaneous: false
EC number: 5.3.1.6
left: D-Ribulose 5-phosphate
name: D-Ribulose 5-phosphate ↔ D-Ribose 5-phosphate
conversion direction: REVERSIBLE

1.1.1.44
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001015 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000479 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
right: D-Ribulose 5-phosphate
right: Carbon dioxide
right: NADPH
spontaneous: false
EC number: 1.1.1.44
left: 6-Phosphogluconic acid
left: NADP
name: 6-Phosphogluconic acid + NADP → Carbon dioxide + D-Ribulose 5-phosphate + NADPH
conversion direction: LEFT_TO_RIGHT

Pyruvate dehydrogenase protein X component
type: ProteinReference
xref: Reference/UniProt Q0P576
organism: Bos taurus

Reference/PubChem-compound 5793
type: UnificationXref
id: 5793
db: PubChem-compound

L-Glutamine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Glutamine

Citrate synthase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q29RK1
organism: Bos taurus

Dihydrolipoyl dehydrogenase
type: ProteinReference
xref: Reference/UniProt F1N206
organism: Bos taurus

Warburg Effect
type: Pathway
pathway order: PathwayEnzymeReaction/2113650
pathway order: PathwayEnzymeReaction/2113651
pathway order: PathwayEnzymeReaction/2113654
pathway order: PathwayEnzymeReaction/2113655
pathway order: PathwayEnzymeReaction/2113652
pathway order: PathwayEnzymeReaction/2113653
pathway order: PathwayEnzymeReaction/2113658
pathway order: PathwayTransport/2113670
pathway order: PathwayEnzymeReaction/2113659
pathway order: PathwayTransport/2113671
pathway order: PathwayEnzymeReaction/2113656
pathway order: PathwayTransport/2113672
pathway order: PathwayEnzymeReaction/2113657
pathway order: PathwayTransport/2113673
pathway order: PathwayTransport/2113674
pathway order: PathwayEnzymeReaction/2113638
pathway order: PathwayEnzymeReaction/2113639
pathway order: PathwayEnzymeReaction/2113661
pathway order: PathwayEnzymeReaction/2113640
pathway order: PathwayEnzymeReaction/2113662
pathway order: PathwayTransport/2113669
pathway order: PathwayEnzymeReaction/2113660
pathway order: PathwayEnzymeReaction/2113643
pathway order: PathwayEnzymeReaction/2113665
pathway order: PathwayEnzymeReaction/2113644
pathway order: PathwayEnzymeReaction/2113666
pathway order: PathwayEnzymeReaction/2113641
pathway order: PathwayEnzymeReaction/2113663
pathway order: PathwayEnzymeReaction/2113642
pathway order: PathwayEnzymeReaction/2113664
pathway order: PathwayEnzymeReaction/2113647
pathway order: PathwayEnzymeReaction/2113648
pathway order: PathwayEnzymeReaction/2113645
pathway order: PathwayEnzymeReaction/2113667
pathway order: PathwayEnzymeReaction/2113646
pathway order: PathwayEnzymeReaction/2113668
pathway order: PathwaySubPathway/108400
pathway order: PathwayEnzymeReaction/2113649
pathway component: ReactionCatalysis136322
pathway component: 2.7.2.3
pathway component: ReactionCatalysis136127
pathway component: TransportCatalysis1045
pathway component: ReactionCatalysis136122
pathway component: ReactionCatalysis136320
pathway component: ReactionCatalysis136321
pathway component: TransportCatalysis1002
pathway component: TransportCatalysis1046
pathway component: ReactionCatalysis136847
pathway component: ReactionCatalysis136326
pathway component: ReactionCatalysis135838
pathway component: Transport7915
pathway component: ReactionCatalysis136846
pathway component: 1.4.1.3
pathway component: Reaction146017
pathway component: 5.3.1.9
pathway component: 2.2.1.2
pathway component: 2.2.1.1
pathway component: 2.7.1.1
pathway component: ReactionCatalysis136851
pathway component: Transport7824
pathway component: ReactionCatalysis136852
pathway component: TransportCatalysis1018
pathway component: Transport7986
pathway component: Transport7985
pathway component: Transport7984
pathway component: Transport7940
pathway component: ReactionCatalysis135768
pathway component: ReactionCatalysis135766
pathway component: ReactionCatalysis135765
pathway component: ReactionCatalysis136856
pathway component: ReactionCatalysis135769
pathway component: 4.1.2.13
pathway component: 3.5.1.2
pathway component: 5.3.1.6
pathway component: 1.1.1.44
pathway component: 2.7.1.11
pathway component: ReactionCatalysis135771
pathway component: TransportCatalysis1026

Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

Reference/PathWhiz PW088289
type: UnificationXref
id: PW088289
db: PathWhiz

ChemicalStructure/PW C000869
type: ChemicalStructure
structure format: SMILES
structure data: OC(COP(O)(O)=O)C=O

Protein/14861 Mitochondrial Matrix/Stoichiometry/2.0
type: Stoichiometry
physical entity: Citrate synthase, mitochondrial
stoichiometric coefficient: 2.0

Reference/PubChem-compound 1198
type: UnificationXref
id: 1198
db: PubChem-compound

Reference/BioCyc FAD
type: UnificationXref
id: FAD
db: BioCyc

ReactionCatalysis136140
type: Catalysis
controller: Glyceraldehyde-3-phosphate dehydrogenase
controlled: Reaction146017
control type: ACTIVATION

SubPathwayControl108400
type: Interaction
name: InhibitorySubPathwayControl
name: SubPathway108400Control
participant: Pyruvate kinase PKM
participant: Pyruvate kinase PKLR
participant: Tyrosine kinase regulation

Reference/BioCyc 3-METHYLBENZYLSUCCINYL-COA
type: UnificationXref
id: 3-METHYLBENZYLSUCCINYL-COA
db: BioCyc

Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
type: ProteinReference
xref: Reference/UniProt P41563
organism: Bos taurus

Reference/CAS 86-01-1
type: UnificationXref
id: 86-01-1
db: CAS

2-oxoglutarate dehydrogenase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q148N0
organism: Bos taurus

Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q148J3
organism: Bos taurus

Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q3MI01
organism: Bos taurus

Compound/PW C000164 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 109096
type: UnificationXref
id: 109096
db: ChemSpider

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

ChemicalStructure/PW C000881
type: ChemicalStructure
structure format: SMILES

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

Reference/UniProt Q3MHX5
type: UnificationXref
id: Q3MHX5
db: UniProt

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/KEGG Compound C00311
type: UnificationXref
id: C00311
db: KEGG Compound

Reference/ChEBI CHEBI 16134
type: UnificationXref
id: CHEBI:16134
db: ChEBI

Reference/PubChem-compound 439278
type: UnificationXref
id: 439278
db: PubChem-compound

Reference/CAS 110-17-8
type: UnificationXref
id: 110-17-8
db: CAS

Reference/UniProt Q3MI01
type: UnificationXref
id: Q3MI01
db: UniProt

Reference/HMDB HMDB0000094
type: UnificationXref
id: HMDB0000094
db: HMDB

Reference/CAS 2641-81-8
type: UnificationXref
id: 2641-81-8
db: CAS

Compound/PW C000101 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Malic acid
stoichiometric coefficient: 1.0

Protein/14890 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial
stoichiometric coefficient: 1.0

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Protein/14905 Mitochondrial Matrix/Stoichiometry/4.0
type: Stoichiometry
physical entity: Pyruvate carboxylase, mitochondrial
stoichiometric coefficient: 4.0

Protein/14924 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001197
type: UnificationXref
id: HMDB0001197
db: HMDB

Fructose-bisphosphate aldolase B
type: Protein
cellular location: Cytosol
entity reference: Fructose-bisphosphate aldolase B

Protein/16125 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Glucose-6-phosphate isomerase
stoichiometric coefficient: 2.0

Cytoplasmic aconitate hydratase
type: Protein
cellular location: Cytosol
entity reference: Cytoplasmic aconitate hydratase

Reference/UniProt Q58CN6
type: UnificationXref
id: Q58CN6
db: UniProt

Reference/ChemSpider 388330
type: UnificationXref
id: 388330
db: ChemSpider

Reference/CAS 2280-44-6
type: UnificationXref
id: 2280-44-6
db: CAS

Reference/BioCyc ALPHA-GLUCOSE-16-BISPHOSPHATE
type: UnificationXref
id: ALPHA-GLUCOSE-16-BISPHOSPHATE
db: BioCyc

Reference/PubChem-compound 5281915
type: UnificationXref
id: 5281915
db: PubChem-compound

FADH
type: SmallMoleculeReference
xref: Reference/PubChem-compound 446013
xref: Reference/ChEBI CHEBI 17877
xref: Reference/BioCyc FADH2
xref: Reference/KEGG Compound C01352
xref: Reference/ChemSpider 393487
xref: Reference/HMDB HMDB0001197
xref: Reference/CAS 1910-41-4
chemical formula: C27H35N9O15P2
molecular weight: 787.1728
structure: ChemicalStructure/PW C000932

Reference/HMDB HMDB0003391
type: UnificationXref
id: HMDB0003391
db: HMDB

Carbon dioxide
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Carbon dioxide

Reference/ChemSpider 709
type: UnificationXref
id: 709
db: ChemSpider

Pyruvate kinase
type: Protein
cellular location: Cytosol
entity reference: Pyruvate kinase

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

Reference/ChemSpider 704
type: UnificationXref
id: 704
db: ChemSpider

Reference/ChemSpider 945
type: UnificationXref
id: 945
db: ChemSpider

Reference/KEGG Compound C00345
type: UnificationXref
id: C00345
db: KEGG Compound

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Guanosine diphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001201
xref: Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
xref: Reference/CAS 146-91-8
xref: Reference/PubChem-compound 8977
xref: Reference/ChEBI CHEBI 17552
xref: Reference/ChemSpider 8630
xref: Reference/KEGG Compound C00035
chemical formula: C10H15N5O11P2
molecular weight: 443.02432
structure: ChemicalStructure/PW C000936

Reference/CAS 488-69-7
type: UnificationXref
id: 488-69-7
db: CAS

Reference/ChEBI CHEBI 30887
type: UnificationXref
id: CHEBI:30887
db: ChEBI

Reference/UniProt P27595
type: UnificationXref
id: P27595
db: UniProt

Reference/KEGG Compound C00117
type: UnificationXref
id: C00117
db: KEGG Compound

Protein/14843 Mitochondrial Matrix/Stoichiometry/60.0
type: Stoichiometry
physical entity: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
stoichiometric coefficient: 60.0

Reference/ChemSpider 388313
type: UnificationXref
id: 388313
db: ChemSpider

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Guanosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15996
xref: Reference/ChemSpider 6569
xref: Reference/KEGG Compound C00044
xref: Reference/PubChem-compound 6830
xref: Reference/HMDB HMDB0001273
xref: Reference/CAS 86-01-1
xref: Reference/BioCyc GTP
chemical formula: C10H16N5O14P3
molecular weight: 522.99066
structure: ChemicalStructure/PW C000986

Compound/PW C000843 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Sedoheptulose 7-phosphate
stoichiometric coefficient: 1.0

Compound/PW C000146 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

L-Glutamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000641
xref: Reference/ChEBI CHEBI 18050
xref: Reference/ChemSpider 5746
xref: Reference/BioCyc GLN
xref: Reference/KEGG Compound C00064
xref: Reference/PubChem-compound 5961
xref: Reference/CAS 56-85-9
chemical formula: C5H10N2O3
molecular weight: 146.06914
structure: ChemicalStructure/PW C000500

Reference/BioCyc CPD-2961
type: UnificationXref
id: CPD-2961
db: BioCyc

Glyceric acid 1,3-biphosphate
type: SmallMoleculeReference
xref: Reference/CAS 1981-49-3
xref: Reference/ChemSpider 663
xref: Reference/BioCyc DPG
xref: Reference/HMDB HMDB0001270
xref: Reference/KEGG Compound C00236
xref: Reference/PubChem-compound 683
chemical formula: C3H8O10P2
molecular weight: 265.95926
structure: ChemicalStructure/PW C000983

Reference/ChemSpider 388559
type: UnificationXref
id: 388559
db: ChemSpider

Reference/KEGG Compound C00111
type: UnificationXref
id: C00111
db: KEGG Compound

Glutamate dehydrogenase 1, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q8HZ49
organism: Bos taurus

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/KEGG Compound C00597
type: UnificationXref
id: C00597
db: KEGG Compound

Reference/KEGG Compound C00354
type: UnificationXref
id: C00354
db: KEGG Compound

1.4.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Mitochondrial Matrix/Stoichiometry/1.0
right: Ammonia
right: Oxoglutaric acid
right: NADH
spontaneous: false
EC number: 1.4.1.3
left: Water
left: L-Glutamic acid
left: NAD
name: L-Glutamic acid + NAD + Water → Ammonia + NADH + Oxoglutaric acid
conversion direction: LEFT_TO_RIGHT

Compound/PW C000134 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxoglutaric acid
stoichiometric coefficient: 1.0

Fructose 1,6-bisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Fructose 1,6-bisphosphate

Compound/PW C000077 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glucose
stoichiometric coefficient: 1.0

Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/ChemSpider 559059
type: UnificationXref
id: 559059
db: ChemSpider

Reference/KEGG Compound C00122
type: UnificationXref
id: C00122
db: KEGG Compound

ChemicalStructure/PW C000932
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 122357
type: UnificationXref
id: 122357
db: PubChem-compound

Reference/CAS 921-62-0
type: UnificationXref
id: 921-62-0
db: CAS

NADH
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: NADH

ChemicalStructure/PW C000936
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/CAS 1910-41-4
type: UnificationXref
id: 1910-41-4
db: CAS

Reference/ChemSpider 1031
type: UnificationXref
id: 1031
db: ChemSpider

Phosphoglycerate kinase 1
type: Protein
cellular location: Cytosol
entity reference: Phosphoglycerate kinase 1

3.5.1.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Mitochondrial Matrix/Stoichiometry/1.0
right: Ammonia
right: L-Glutamic acid
spontaneous: false
EC number: 3.5.1.2
left: L-Glutamine
left: Water
name: L-Glutamine + Water → Ammonia + L-Glutamic acid
conversion direction: LEFT_TO_RIGHT

Pyruvic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyruvic acid

FAD
type: SmallMoleculeReference
xref: Reference/CAS 146-14-5
xref: Reference/HMDB HMDB0001248
xref: Reference/ChEBI CHEBI 16238
xref: Reference/BioCyc FAD
xref: Reference/PubChem-compound 643975
xref: Reference/ChemSpider 559059
xref: Reference/KEGG Compound C00016
chemical formula: C27H33N9O15P2
molecular weight: 785.1571
structure: ChemicalStructure/PW C000964

Reference/ChemSpider 388538
type: UnificationXref
id: 388538
db: ChemSpider

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H28N7O14P2
molecular weight: 664.11694
structure: ChemicalStructure/PW C000721

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Reference/UniProt Q2TBL6
type: UnificationXref
id: Q2TBL6
db: UniProt

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Reference/UniProt Q8HZ49
type: UnificationXref
id: Q8HZ49
db: UniProt

Fumarate hydratase, mitochondrial
type: Complex
component stoichiometry: Protein/14899 Mitochondrial Matrix/Stoichiometry/4.0
cellular location: Mitochondrial Matrix
component: Fumarate hydratase

Reference/KEGG Compound C00149
type: UnificationXref
id: C00149
db: KEGG Compound

Reference/ChemSpider 388307
type: UnificationXref
id: 388307
db: ChemSpider

Reference/UniProt E1BHZ6
type: UnificationXref
id: E1BHZ6
db: UniProt

Reference/KEGG Compound C01236
type: UnificationXref
id: C01236
db: KEGG Compound

Reference/ChemSpider 62713
type: UnificationXref
id: 62713
db: ChemSpider

Aconitate hydratase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Aconitate hydratase, mitochondrial

Fumaric acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Fumaric acid

Reference/KEGG Compound C00390
type: UnificationXref
id: C00390
db: KEGG Compound

Protein/14848 Mitochondrial Matrix/Stoichiometry/60.0
type: Stoichiometry
physical entity: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
stoichiometric coefficient: 60.0

Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

Compound/PW C001191 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Ribose 5-phosphate
stoichiometric coefficient: 1.0

TransportCatalysis1045
type: Catalysis
controller: Solute carrier family 2, facilitated glucose transporter member 2
controlled: Transport7984
control type: ACTIVATION

TransportCatalysis1046
type: Catalysis
controller: Monocarboxylate transporter 1
controlled: Transport7985
control type: ACTIVATION

Reference/CAS 56275-39-9
type: UnificationXref
id: 56275-39-9
db: CAS

Reference/KEGG Compound C00158
type: UnificationXref
id: C00158
db: KEGG Compound

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/CAS 328-50-7
type: UnificationXref
id: 328-50-7
db: CAS

Reference/HMDB HMDB0000254
type: UnificationXref
id: HMDB0000254
db: HMDB

L-Lactic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Lactic acid

D-Glucose
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Glucose

L-Lactic acid
type: SmallMolecule
cellular location: Extracellular Space
entity reference: L-Lactic acid

Phosphoglycerate mutase 2
type: ProteinReference
xref: Reference/UniProt Q32KV0
organism: Bos taurus

Alpha-enolase
type: ProteinReference
xref: Reference/UniProt Q3SYW4
organism: Bos taurus

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Transport7824
type: Transport
participant stoichiometry: Compound/PW C000164 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Mitochondrial Matrix/Stoichiometry/1.0
right: Pyruvic acid
spontaneous: false
left: Pyruvic acid
name: Pyruvic acid (→) Transport: Bos taurus, Cell, Cytosol to Bos taurus, Cell, Mitochondrial Matrix
conversion direction: LEFT_TO_RIGHT

Compound/PW C001104 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Glutaminase 2
type: ProteinReference
xref: Reference/UniProt E1BHZ6
organism: Bos taurus

Solute carrier family 2, facilitated glucose transporter member 2
type: Protein
entity reference: Solute carrier family 2, facilitated glucose transporter member 2

Citrate synthase, mitochondrial
type: Complex
component stoichiometry: Protein/14861 Mitochondrial Matrix/Stoichiometry/2.0
cellular location: Mitochondrial Matrix
component: Citrate synthase, mitochondrial

Reference/ChemSpider 4445197
type: UnificationXref
id: 4445197
db: ChemSpider

Reference/CAS 303-98-0
type: UnificationXref
id: 303-98-0
db: CAS

Reference/HMDB HMDB0001112
type: UnificationXref
id: HMDB0001112
db: HMDB

6-phosphogluconolactonase
type: Protein
cellular location: Cytosol
entity reference: 6-phosphogluconolactonase

ChemicalStructure/PW C000063
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC(O)(CC(O)=O)C(O)=O

Reference/UniProt Q6B855
type: UnificationXref
id: Q6B855
db: UniProt

Reference/ChemSpider 762
type: UnificationXref
id: 762
db: ChemSpider

Reference/BioCyc PHOSPHO-ENOL-PYRUVATE
type: UnificationXref
id: PHOSPHO-ENOL-PYRUVATE
db: BioCyc

Reference/UniProt Q148J3
type: UnificationXref
id: Q148J3
db: UniProt

Pyruvate kinase
type: ProteinReference
xref: Reference/UniProt F1MIZ0
organism: Bos taurus

Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial

Reference/HMDB HMDB0000263
type: UnificationXref
id: HMDB0000263
db: HMDB

ReactionCatalysis135771
type: Catalysis
controller: Succinyl-CoA ligase
controlled: Reaction145704
control type: ACTIVATION

Succinyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Succinyl-CoA

Reference/ChemSpider 10197150
type: UnificationXref
id: 10197150
db: ChemSpider

ReactionCatalysis135775
type: Catalysis
controller: Pyruvate carboxylase, mitochondrial
controlled: 6.4.1.1
control type: ACTIVATION

Reference/UniProt F2Z4G6
type: UnificationXref
id: F2Z4G6
db: UniProt

ReactionCatalysis135774
type: Catalysis
controller: Malate dehydrogenase, cytoplasmic
controlled: Reaction145707
control type: ACTIVATION

Reference/PubChem-compound 668
type: UnificationXref
id: 668
db: PubChem-compound

ReactionCatalysis135772
type: Catalysis
controller: Fumarate hydratase, mitochondrial
controlled: 4.2.1.2
control type: ACTIVATION

Ammonia
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Ammonia

1.3.5.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001006 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000088 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000174 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000964 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000932 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000846 Mitochondrial Matrix/Stoichiometry/1.0
right: Fumaric acid
right: FADH
right: QH2
spontaneous: false
EC number: 1.3.5.1
left: Succinic acid
left: FAD
left: Coenzyme Q10
name: Coenzyme Q10 + FAD + Succinic acid ↔ FADH + Fumaric acid + QH2
conversion direction: REVERSIBLE

6.4.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001034 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000148 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000463 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Mitochondrial Matrix/Stoichiometry/1.0
right: Oxalacetic acid
right: Phosphate
right: Adenosine diphosphate
spontaneous: false
EC number: 6.4.1.1
left: Pyruvic acid
left: Adenosine triphosphate
left: Hydrogen carbonate
name: Adenosine triphosphate + Hydrogen carbonate + Pyruvic acid → Adenosine diphosphate + Oxalacetic acid + Phosphate
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis135776
type: Catalysis
controller: Succinate dehydrogenase
controlled: 1.3.5.1
control type: ACTIVATION

Glyceraldehyde-3-phosphate dehydrogenase
type: Complex
component stoichiometry: Protein/15676 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Glyceraldehyde-3-phosphate dehydrogenase

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reaction145707
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000101 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000148 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
right: Oxalacetic acid
right: NADH
right: Hydrogen Ion
spontaneous: false
left: L-Malic acid
left: NAD
name: L-Malic acid + NAD ↔ Hydrogen Ion + NADH + Oxalacetic acid
conversion direction: REVERSIBLE

4.2.1.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000101 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000088 Mitochondrial Matrix/Stoichiometry/1.0
right: Fumaric acid
right: Water
spontaneous: false
EC number: 4.2.1.2
left: L-Malic acid
name: L-Malic acid ↔ Fumaric acid + Water
conversion direction: REVERSIBLE

Reference/CAS 591-59-3
type: UnificationXref
id: 591-59-3
db: CAS

Reaction145704
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000808 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000986 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000936 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000174 Mitochondrial Matrix/Stoichiometry/1.0
right: Succinic acid
right: Coenzyme A
right: Guanosine triphosphate
spontaneous: false
left: Succinyl-CoA
left: Phosphate
left: Guanosine diphosphate
name: Guanosine diphosphate + Phosphate + Succinyl-CoA ↔ Coenzyme A + Guanosine triphosphate + Succinic acid
conversion direction: REVERSIBLE

1.2.4.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000808 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
right: Succinyl-CoA
right: Carbon dioxide
right: NADH
right: Hydrogen Ion
spontaneous: false
EC number: 1.2.4.2
left: Coenzyme A
left: Oxoglutaric acid
left: NAD
name: Coenzyme A + NAD + Oxoglutaric acid → Carbon dioxide + Hydrogen Ion + NADH + Succinyl-CoA
conversion direction: LEFT_TO_RIGHT

1.1.1.41
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000125 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
right: Carbon dioxide
right: Oxoglutaric acid
right: NADH
right: Hydrogen Ion
spontaneous: false
EC number: 1.1.1.41
left: Isocitric acid
left: NAD
name: Isocitric acid + NAD → Carbon dioxide + Hydrogen Ion + NADH + Oxoglutaric acid
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 22833559
type: UnificationXref
id: 22833559
db: PubChem-compound

Reference/HMDB HMDB0001127
type: UnificationXref
id: HMDB0001127
db: HMDB

Reference/BioCyc AMMONIA
type: UnificationXref
id: AMMONIA
db: BioCyc

ChemicalStructure/PW C000035
type: ChemicalStructure
structure format: SMILES
structure data: N

Unknown
type: Protein
entity reference: Unknown

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

Reference/CAS 585-18-2
type: UnificationXref
id: 585-18-2
db: CAS

Neutral amino acid transporter B(0)
type: ProteinReference
xref: Reference/UniProt Q08DD9

Reference/HMDB HMDB0001362
type: UnificationXref
id: HMDB0001362
db: HMDB

NAD
type: SmallMolecule
cellular location: Cytosol
entity reference: NAD

Reference/KEGG Compound C00186
type: UnificationXref
id: C00186
db: KEGG Compound

Protein/17154 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Transketolase
stoichiometric coefficient: 2.0

Monocarboxylate transporter 1
type: Protein
entity reference: Monocarboxylate transporter 1

Reference/ChemSpider 305
type: UnificationXref
id: 305
db: ChemSpider

Reference/PubChem-compound 445557
type: UnificationXref
id: 445557
db: PubChem-compound

2-Phospho-D-glyceric acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 439278
xref: Reference/ChemSpider 388411
xref: Reference/ChEBI CHEBI 17835
xref: Reference/HMDB HMDB0003391
xref: Reference/BioCyc 2-PG
xref: Reference/KEGG Compound C00631
chemical formula: C3H7O7P
molecular weight: 185.99294
structure: ChemicalStructure/PW C001870

Reference/ChEBI CHEBI 17050
type: UnificationXref
id: CHEBI:17050
db: ChEBI

ChemicalStructure/PW C001134
type: ChemicalStructure
structure format: SMILES
structure data: OCC(=O)COP(O)(O)=O

Reference/UniProt Q0VCU1
type: UnificationXref
id: Q0VCU1
db: UniProt

Solute carrier family 2, facilitated glucose transporter member 2
type: ProteinReference
xref: Reference/UniProt A6QPH3

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Reference/BioCyc RIBULOSE-5P
type: UnificationXref
id: RIBULOSE-5P
db: BioCyc

TransportCatalysis1002
type: Catalysis
controller: Mitochondrial pyruvate carrier 1
controlled: Transport7824
control type: ACTIVATION

ReactionCatalysis136847
type: Catalysis
controller: Ribose-5-phosphate isomerase
controlled: 5.3.1.6
control type: ACTIVATION

Reference/KEGG Compound C00199
type: UnificationXref
id: C00199
db: KEGG Compound

Reference/ChemSpider 979
type: UnificationXref
id: 979
db: ChemSpider

QH2
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: QH2

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

ReactionCatalysis136846
type: Catalysis
controller: 6-phosphogluconate dehydrogenase, decarboxylating
controlled: 1.1.1.44
control type: ACTIVATION

Water
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Water

Phosphoric acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/ChEBI CHEBI 26078
xref: Reference/CAS 7664-38-2
xref: Reference/PubChem-compound 1004
xref: Reference/ChemSpider 979
xref: Reference/HMDB HMDB0002142
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001441

Isocitrate dehydrogenase [NADP] cytoplasmic
type: ProteinReference
xref: Reference/UniProt Q3SYV2
organism: Bos taurus

Reference/HMDB HMDB0000051
type: UnificationXref
id: HMDB0000051
db: HMDB

Malate dehydrogenase, cytoplasmic
type: ProteinReference
xref: Reference/UniProt Q3T145
organism: Bos taurus

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

ReactionCatalysis136851
type: Catalysis
controller: Transketolase
controlled: 2.2.1.1
control type: ACTIVATION

Reference/CAS 146-14-5
type: UnificationXref
id: 146-14-5
db: CAS

ReactionCatalysis136852
type: Catalysis
controller: Transaldolase
controlled: 2.2.1.2
control type: ACTIVATION

TransportCatalysis1018
type: Catalysis
controller: Neutral amino acid transporter B(0)
controlled: Transport7915
control type: ACTIVATION

Reference/ChEBI CHEBI 44897
type: UnificationXref
id: CHEBI:44897
db: ChEBI

2-oxoglutarate dehydrogenase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: 2-oxoglutarate dehydrogenase, mitochondrial

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

ReactionCatalysis135768
type: Catalysis
controller: Isocitrate dehydrogenase
controlled: 1.1.1.41
control type: ACTIVATION

ReactionCatalysis135766
type: Catalysis
controller: Citrate synthase, mitochondrial
controlled: 2.3.3.1
control type: ACTIVATION

ReactionCatalysis135765
type: Catalysis
controller: Pyruvate dehydrogenase complex
controlled: 1.2.4.1
control type: ACTIVATION

Pyruvate carboxylase, mitochondrial
type: Complex
component stoichiometry: Protein/14905 Mitochondrial Matrix/Stoichiometry/4.0
cellular location: Mitochondrial Matrix
component: Pyruvate carboxylase, mitochondrial

Pyruvate dehydrogenase protein X component
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Pyruvate dehydrogenase protein X component

Reference/BioCyc GTP
type: UnificationXref
id: GTP
db: BioCyc

ReactionCatalysis136856
type: Catalysis
controller: Glucose-6-phosphate isomerase
controlled: 5.3.1.9
control type: ACTIVATION

ReactionCatalysis135769
type: Catalysis
controller: Oxoglutarate dehydrogenase complex
controlled: 1.2.4.2
control type: ACTIVATION

Reference/BioCyc RIBOSE-5P
type: UnificationXref
id: RIBOSE-5P
db: BioCyc

ChemicalStructure/PW C001191
type: ChemicalStructure
structure format: SMILES
structure data: OC1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O

Reference/UniProt Q148N0
type: UnificationXref
id: Q148N0
db: UniProt

L-Lactic acid
type: SmallMoleculeReference
xref: Reference/CAS 79-33-4
xref: Reference/ChEBI CHEBI 422
xref: Reference/HMDB HMDB0000190
xref: Reference/PubChem-compound 107689
xref: Reference/KEGG Compound C00186
xref: Reference/BioCyc L-LACTATE
xref: Reference/ChemSpider 96860
chemical formula: C3H6O3
molecular weight: 90.03169
structure: ChemicalStructure/PW C000122

TransportCatalysis1026
type: Catalysis
controller: Unknown
controlled: Transport7940
control type: ACTIVATION

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

Reference/CAS 56-73-5
type: UnificationXref
id: 56-73-5
db: CAS

Reference/BioCyc 2-PG
type: UnificationXref
id: 2-PG
db: BioCyc

ChemicalStructure/PW C000077
type: ChemicalStructure
structure format: SMILES
structure data: OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O

Compound/PW C001441 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoric acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

ChemicalStructure/PW C000079
type: ChemicalStructure
structure format: SMILES

Glucose-6-phosphate isomerase
type: ProteinReference
xref: Reference/UniProt O46595
organism: Bos taurus

Hydrogen carbonate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Hydrogen carbonate

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Ribose-5-phosphate isomerase
type: Protein
cellular location: Cytosol
entity reference: Ribose-5-phosphate isomerase

Compound/PW C001316 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/ChemSpider 749
type: UnificationXref
id: 749
db: ChemSpider

Reference/CAS 71-52-3
type: UnificationXref
id: 71-52-3
db: CAS

ChemicalStructure/PW C000088
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)\C=C\C(O)=O

Reference/ChemSpider 980
type: UnificationXref
id: 980
db: ChemSpider

Reference/UniProt Q3SZZ1
type: UnificationXref
id: Q3SZZ1
db: UniProt

Reference/CAS 146-91-8
type: UnificationXref
id: 146-91-8
db: CAS

L-Malic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000156
xref: Reference/ChEBI CHEBI 30797
xref: Reference/KEGG Compound C00149
xref: Reference/ChemSpider 193317
xref: Reference/PubChem-compound 222656
xref: Reference/CAS 97-67-6
chemical formula: C4H6O5
molecular weight: 134.02153
structure: ChemicalStructure/PW C000101

2-Phospho-D-glyceric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: 2-Phospho-D-glyceric acid

Compound/PW C001134 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydroxyacetone phosphate
stoichiometric coefficient: 1.0

Protein/14855 Mitochondrial Matrix/Stoichiometry/60.0
type: Stoichiometry
physical entity: Pyruvate dehydrogenase protein X component
stoichiometric coefficient: 60.0

Oxalacetic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000223
xref: Reference/CAS 328-42-7
xref: Reference/ChEBI CHEBI 30744
xref: Reference/BioCyc OXALACETIC ACID
xref: Reference/ChemSpider 945
xref: Reference/PubChem-compound 970
xref: Reference/KEGG Compound C00036
chemical formula: C4H4O5
molecular weight: 132.00587
structure: ChemicalStructure/PW C000148

Adenosine triphosphate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Adenosine triphosphate

Compound/PW C000983 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glyceric acid 1,3-biphosphate
stoichiometric coefficient: 1.0

Compound/PW C000833 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fructose 1,6-bisphosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/BioCyc CIT
type: UnificationXref
id: CIT
db: BioCyc

Reference/UniProt Q5UAB3
type: UnificationXref
id: Q5UAB3
db: UniProt

Reference/PubChem-compound 58838673
type: UnificationXref
id: 58838673
db: PubChem-compound

QH2
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001304
xref: Reference/BioCyc QH2
xref: Reference/PubChem-compound 5280344
xref: Reference/KEGG Compound C00390
xref: Reference/CAS 56275-39-9
xref: Reference/ChemSpider 4444052
chemical formula: (C5H8)nC14H20O4
structure: ChemicalStructure/PW C001006

Reference/PubChem-compound 1004
type: UnificationXref
id: 1004
db: PubChem-compound

Reference/PubChem-compound 1005
type: UnificationXref
id: 1005
db: PubChem-compound

Compound/PW C000143 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Reference/CAS 328-42-7
type: UnificationXref
id: 328-42-7
db: CAS

ChemicalStructure/PW C000101
type: ChemicalStructure
structure format: SMILES
structure data: O[C@@H](CC(O)=O)C(O)=O

6-Phosphogluconic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 48928
xref: Reference/BioCyc CPD-2961
xref: Reference/HMDB HMDB0001316
xref: Reference/CAS 921-62-0
xref: Reference/PubChem-compound 91493
xref: Reference/ChemSpider 82615
xref: Reference/KEGG Compound C00345
chemical formula: C6H13O10P
molecular weight: 276.02463
structure: ChemicalStructure/PW C001015

Compound/PW C000936 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine diphosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/ChEBI CHEBI 16938
type: UnificationXref
id: CHEBI:16938
db: ChEBI

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

6-Phosphogluconic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: 6-Phosphogluconic acid

Pyruvic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 1060
xref: Reference/HMDB HMDB0000243
xref: Reference/CAS 127-17-3
xref: Reference/BioCyc PYRUVATE
xref: Reference/KEGG Compound C00022
xref: Reference/ChEBI CHEBI 32816
xref: Reference/ChemSpider 1031
chemical formula: C3H4O3
molecular weight: 88.016045
structure: ChemicalStructure/PW C000164

Reference/UniProt F1MIZ0
type: UnificationXref
id: F1MIZ0
db: UniProt

6-Phosphonoglucono-D-lactone
type: SmallMolecule
cellular location: Cytosol
entity reference: 6-Phosphonoglucono-D-lactone

Compound/PW C000986 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine triphosphate
stoichiometric coefficient: 1.0

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Hexokinase-1
type: ProteinReference
xref: Reference/UniProt P27595
organism: Bos taurus

Succinate dehydrogenase
type: Complex
component stoichiometry: Protein/14910 Mitochondrial Matrix/Stoichiometry/1.0
component stoichiometry: Protein/14919 Mitochondrial Matrix/Stoichiometry/1.0
component stoichiometry: Protein/14924 Mitochondrial Matrix/Stoichiometry/1.0
component stoichiometry: Protein/14914 Mitochondrial Matrix/Stoichiometry/1.0
cellular location: Mitochondrial Matrix
component: Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
component: Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
component: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
component: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Isocitric acid
type: SmallMoleculeReference
xref: Reference/CAS 320-77-4
xref: Reference/BioCyc threo-d(s)-iso-citrate
xref: Reference/ChEBI CHEBI 30887
xref: Reference/ChemSpider 1161
xref: Reference/HMDB HMDB0000193
xref: Reference/KEGG Compound C00311
xref: Reference/PubChem-compound 1198
chemical formula: C6H8O7
molecular weight: 192.02701
structure: ChemicalStructure/PW C000125

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Glutamate dehydrogenase 1, mitochondrial
type: Complex
component stoichiometry: Protein/15098 Mitochondrial Matrix/Stoichiometry/6.0
cellular location: Mitochondrial Matrix
component: Glutamate dehydrogenase 1, mitochondrial

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Phosphoglycerate kinase 1
type: ProteinReference
xref: Reference/UniProt Q3T0P6
organism: Bos taurus

Oxoglutaric acid
type: SmallMoleculeReference
xref: Reference/CAS 328-50-7
xref: Reference/PubChem-compound 51
xref: Reference/BioCyc 2-KETOGLUTARATE
xref: Reference/HMDB HMDB0000208
xref: Reference/ChEBI CHEBI 30915
xref: Reference/KEGG Compound C00026
xref: Reference/ChemSpider 50
chemical formula: C5H6O5
molecular weight: 146.02153
structure: ChemicalStructure/PW C000134

Reference/ChEBI CHEBI 16905
type: UnificationXref
id: CHEBI:16905
db: ChEBI

Reference/ChemSpider 393487
type: UnificationXref
id: 393487
db: ChemSpider

Monocarboxylate transporter 1
type: ProteinReference
xref: Reference/UniProt Q3MHW6

Citric acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Citric acid

Reference/UniProt A1A4J1
type: UnificationXref
id: A1A4J1
db: UniProt

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Protein/14919 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
stoichiometric coefficient: 1.0

Glutamate dehydrogenase 1, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Glutamate dehydrogenase 1, mitochondrial

Reference/CAS 77-92-9
type: UnificationXref
id: 77-92-9
db: CAS

Compound/PW C000644 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Phosphoglyceric acid
stoichiometric coefficient: 1.0

Phosphoglycerate mutase 2
type: Protein
cellular location: Cytosol
entity reference: Phosphoglycerate mutase 2

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

1.1.1.27
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000122 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytosol/Stoichiometry/1.0
right: Pyruvic acid
right: Hydrogen Ion
right: NADH
spontaneous: false
EC number: 1.1.1.27
left: NAD
left: L-Lactic acid
name: L-Lactic acid + NAD ↔ Hydrogen Ion + NADH + Pyruvic acid
conversion direction: REVERSIBLE

6-phosphogluconate dehydrogenase, decarboxylating
type: ProteinReference
xref: Reference/UniProt F2Z4G6
organism: Bos taurus

Reference/BioCyc L-LACTATE
type: UnificationXref
id: L-LACTATE
db: BioCyc

Cytoplasmic aconitate hydratase
type: ProteinReference
xref: Reference/UniProt Q0VCU1
organism: Bos taurus

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H29N7O17P3
molecular weight: 744.08325
structure: ChemicalStructure/PW C000143

Protein/14887 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
stoichiometric coefficient: 1.0

2.7.1.40
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000180 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: Phosphoenolpyruvic acid
spontaneous: false
EC number: 2.7.1.40
left: Adenosine triphosphate
left: Pyruvic acid
name: Adenosine triphosphate + Pyruvic acid ↔ Adenosine diphosphate + Phosphoenolpyruvic acid
conversion direction: REVERSIBLE

4.2.1.11
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000180 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001870 Cytosol/Stoichiometry/1.0
right: Phosphoenolpyruvic acid
right: Water
spontaneous: false
EC number: 4.2.1.11
left: 2-Phospho-D-glyceric acid
name: 2-Phospho-D-glyceric acid ↔ Phosphoenolpyruvic acid + Water
conversion direction: REVERSIBLE

Reaction146183
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000644 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001870 Cytosol/Stoichiometry/1.0
right: 2-Phospho-D-glyceric acid
spontaneous: false
left: 3-Phosphoglyceric acid
name: 3-Phosphoglyceric acid ↔ 2-Phospho-D-glyceric acid
conversion direction: REVERSIBLE

2.7.2.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000644 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000983 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine triphosphate
right: 3-Phosphoglyceric acid
spontaneous: false
EC number: 2.7.2.3
left: Adenosine diphosphate
left: Glyceric acid 1,3-biphosphate
name: Adenosine diphosphate + Glyceric acid 1,3-biphosphate → 3-Phosphoglyceric acid + Adenosine triphosphate
conversion direction: LEFT_TO_RIGHT

Reference/UniProt Q866R1
type: UnificationXref
id: Q866R1
db: UniProt

Reference/HMDB HMDB0000208
type: UnificationXref
id: HMDB0000208
db: HMDB

Reference/PubChem-compound 683
type: UnificationXref
id: 683
db: PubChem-compound

Phosphoenolpyruvic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphoenolpyruvic acid

Reference/UniProt Q148D3
type: UnificationXref
id: Q148D3
db: UniProt

Protein/14910 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001304
type: UnificationXref
id: HMDB0001304
db: HMDB

ChemicalStructure/PW C000134
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(=O)C(O)=O

Reference/HMDB HMDB0001548
type: UnificationXref
id: HMDB0001548
db: HMDB

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Compound/PW C000500 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamine
stoichiometric coefficient: 1.0

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Guanosine diphosphate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Guanosine diphosphate

Protein/14914 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
stoichiometric coefficient: 1.0

5.3.1.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001083 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000079 Cytosol/Stoichiometry/1.0
right: Glucose 6-phosphate
spontaneous: false
EC number: 5.3.1.9
left: Fructose 6-phosphate
name: Fructose 6-phosphate ↔ Glucose 6-phosphate
conversion direction: REVERSIBLE

2.7.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000077 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001083 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Glucose 6-phosphate
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.1.1
left: Adenosine triphosphate
left: D-Glucose
name: Adenosine triphosphate + D-Glucose → Adenosine diphosphate + Glucose 6-phosphate
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 17835
type: UnificationXref
id: CHEBI:17835
db: ChEBI

Reference/BioCyc GLC
type: UnificationXref
id: GLC
db: BioCyc

Compound/PW C000721 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Tyrosine kinase regulation
type: Pathway
name: InhibitorySubPathway

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Reference/HMDB HMDB0000223
type: UnificationXref
id: HMDB0000223
db: HMDB

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc GLN
type: UnificationXref
id: GLN
db: BioCyc

Reference/HMDB HMDB0001316
type: UnificationXref
id: HMDB0001316
db: HMDB

Hydrogen
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

Reference/CAS 7664-41-7
type: UnificationXref
id: 7664-41-7
db: CAS

Compound/PW C000088 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fumaric acid
stoichiometric coefficient: 1.0

Reference/CAS 57-04-5
type: UnificationXref
id: 57-04-5
db: CAS

Reference/PubChem-compound 69507
type: UnificationXref
id: 69507
db: PubChem-compound

Hydrogen
type: SmallMoleculeReference
xref: Reference/PubChem-compound 58838673
xref: Reference/CAS 1333-74-0
xref: Reference/ChemSpider 762
xref: Reference/BioCyc ALPHA-GLUCOSE-16-BISPHOSPHATE
xref: Reference/KEGG Compound C00282
xref: Reference/HMDB HMDB0001362
xref: Reference/ChEBI CHEBI 18276
chemical formula: H2
molecular weight: 2.01565
structure: ChemicalStructure/PW C001051

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: Reference/UniProt Q3ZCB1
organism: Bos taurus

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

D-Erythrose 4-phosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 48153
xref: Reference/HMDB HMDB0001321
xref: Reference/CAS 585-18-2
xref: Reference/BioCyc ERYTHROSE-4P
xref: Reference/PubChem-compound 122357
xref: Reference/ChemSpider 109096
xref: Reference/KEGG Compound C00279
chemical formula: C4H9O7P
molecular weight: 200.00859
structure: ChemicalStructure/PW C001019

Reference/ChemSpider 4444052
type: UnificationXref
id: 4444052
db: ChemSpider

Reference/PubChem-compound 222
type: UnificationXref
id: 222
db: PubChem-compound

Hydrogen Ion
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Hydrogen Ion

ChemicalStructure/PW C001441
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/UniProt Q29RK1
type: UnificationXref
id: Q29RK1
db: UniProt

Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001321
type: UnificationXref
id: HMDB0001321
db: HMDB

Reference/PubChem-compound 5280344
type: UnificationXref
id: 5280344
db: PubChem-compound

Reference/UniProt Q9TUY8
type: UnificationXref
id: Q9TUY8
db: UniProt

Succinic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000254
xref: Reference/CAS 110-15-6
xref: Reference/ChEBI CHEBI 15741
xref: Reference/KEGG Compound C00042
xref: Reference/ChemSpider 1078
xref: Reference/PubChem-compound 1110
xref: Reference/BioCyc SUC
chemical formula: C4H6O4
molecular weight: 118.02661
structure: ChemicalStructure/PW C000174

Reference/CAS 60802-29-1
type: UnificationXref
id: 60802-29-1
db: CAS

Reference/CAS 320-77-4
type: UnificationXref
id: 320-77-4
db: CAS

Reference/BioCyc threo-d(s)-iso-citrate
type: UnificationXref
id: threo-d(s)-iso-citrate
db: BioCyc

Reference/BioCyc ERYTHROSE-4P
type: UnificationXref
id: ERYTHROSE-4P
db: BioCyc

Reference/UniProt Q32KV0
type: UnificationXref
id: Q32KV0
db: UniProt

Reference/HMDB HMDB0000243
type: UnificationXref
id: HMDB0000243
db: HMDB

Phosphoenolpyruvic acid
type: SmallMoleculeReference
xref: Reference/CAS 138-08-9
xref: Reference/ChEBI CHEBI 44897
xref: Reference/KEGG Compound C00074
xref: Reference/BioCyc PHOSPHO-ENOL-PYRUVATE
xref: Reference/ChemSpider 980
xref: Reference/PubChem-compound 1005
xref: Reference/HMDB HMDB0000263
chemical formula: C3H5O6P
molecular weight: 167.98238
structure: ChemicalStructure/PW C000180

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

ChemicalStructure/PW C000125
type: ChemicalStructure
structure format: SMILES
structure data: OC(C(CC(O)=O)C(O)=O)C(O)=O

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000122
type: ChemicalStructure
structure format: SMILES
structure data: C[C@@H](O)C(O)=O

Reference/CAS 4151-19-3
type: UnificationXref
id: 4151-19-3
db: CAS

D-Glyceraldehyde 3-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Glyceraldehyde 3-phosphate

Isocitrate dehydrogenase
type: Complex
component stoichiometry: Protein/14874 Mitochondrial Matrix/Stoichiometry/1.0
component stoichiometry: Protein/14868 Mitochondrial Matrix/Stoichiometry/2.0
component stoichiometry: Protein/14871 Mitochondrial Matrix/Stoichiometry/1.0
cellular location: Mitochondrial Matrix
component: Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
component: Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
component: Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial

ChemicalStructure/PW C000964
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Reference/PubChem-compound 19782904
type: UnificationXref
id: 19782904
db: PubChem-compound

Pyruvate carboxylase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Pyruvate carboxylase, mitochondrial

Reference/HMDB HMDB0000807
type: UnificationXref
id: HMDB0000807
db: HMDB

Dihydroxyacetone phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Dihydroxyacetone phosphate

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

Oxalacetic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Oxalacetic acid

Reference/ChemSpider 17216052
type: UnificationXref
id: 17216052
db: ChemSpider

Reference/UniProt Q3T0S5
type: UnificationXref
id: Q3T0S5
db: UniProt

Reference/UniProt Q3T145
type: UnificationXref
id: Q3T145
db: UniProt

Glucose 6-phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00092
xref: Reference/BioCyc GLC-6-P
xref: Reference/HMDB HMDB0001401
xref: Reference/PubChem-compound 5958
xref: Reference/ChemSpider 5743
xref: Reference/CAS 56-73-5
xref: Reference/ChEBI CHEBI 4170
chemical formula: C6H13O9P
molecular weight: 260.02972
structure: ChemicalStructure/PW C001083

Reference/UniProt O46595
type: UnificationXref
id: O46595
db: UniProt

Reference/ChEBI CHEBI 17877
type: UnificationXref
id: CHEBI:17877
db: ChEBI

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Bos taurus
type: BioSource
xref: Reference/TAXONOMY 9913

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine diphosphate

ChemicalStructure/PW C000983
type: ChemicalStructure
structure format: SMILES
structure data: OC(COP(O)(O)=O)C(=O)OP(O)(O)=O

Isocitric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Isocitric acid

Reference/UniProt F1N206
type: UnificationXref
id: F1N206
db: UniProt

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Reference/PubChem-compound 91493
type: UnificationXref
id: 91493
db: PubChem-compound

ATP-dependent 6-phosphofructokinase, liver type
type: ProteinReference
xref: Reference/UniProt A1A4J1
organism: Bos taurus

Reference/PubChem-compound 439427
type: UnificationXref
id: 439427
db: PubChem-compound

Compound/PW C001906 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: β-D-Glucose 6-phosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/ChemSpider 5589
type: UnificationXref
id: 5589
db: ChemSpider

Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Compound/PW C001034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Compound/PW C001870 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Phospho-D-glyceric acid
stoichiometric coefficient: 1.0

Protein/14881 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 48153
type: UnificationXref
id: CHEBI:48153
db: ChEBI

Reference/CAS 79-33-4
type: UnificationXref
id: 79-33-4
db: CAS

Reference/PubChem-compound 439452
type: UnificationXref
id: 439452
db: PubChem-compound

Compound/PW C000500 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamine
stoichiometric coefficient: 1.0

Reference/BioCyc FRUCTOSE-16-DIPHOSPHATE
type: UnificationXref
id: FRUCTOSE-16-DIPHOSPHATE
db: BioCyc

Fructose-bisphosphate aldolase B
type: ProteinReference
xref: Reference/UniProt Q3T0S5
organism: Bos taurus

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Oxoglutarate dehydrogenase complex
type: Complex
component stoichiometry: Protein/14860 Mitochondrial Matrix/Stoichiometry/2.0
component stoichiometry: Protein/14876 Mitochondrial Matrix/Stoichiometry/1.0
component stoichiometry: Protein/14881 Mitochondrial Matrix/Stoichiometry/1.0
cellular location: Mitochondrial Matrix
component: 2-oxoglutarate dehydrogenase, mitochondrial
component: Dihydrolipoyl dehydrogenase
component: Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

Reference/UniProt Q3T0P6
type: UnificationXref
id: Q3T0P6
db: UniProt

Reference/PubChem-compound 8977
type: UnificationXref
id: 8977
db: PubChem-compound

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial

Compound/PW C000079 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fructose 6-phosphate
stoichiometric coefficient: 1.0

Glucose 6-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Glucose 6-phosphate

6-phosphogluconate dehydrogenase, decarboxylating
type: Protein
cellular location: Cytosol
entity reference: 6-phosphogluconate dehydrogenase, decarboxylating

Compound/PW C000964 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: FAD
stoichiometric coefficient: 1.0

Oxoglutaric acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Oxoglutaric acid

Reference/UniProt Q58DR8
type: UnificationXref
id: Q58DR8
db: UniProt

Reference/SMPDB SMP0087270
type: UnificationXref
id: SMP0087270
db: SMPDB

Reference/KEGG Compound C00631
type: UnificationXref
id: C00631
db: KEGG Compound

Reference/ChemSpider 8630
type: UnificationXref
id: 8630
db: ChemSpider

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/ChEBI CHEBI 16332
type: UnificationXref
id: CHEBI:16332
db: ChEBI

Reference/UniProt Q08DD9
type: UnificationXref
id: Q08DD9
db: UniProt

Reference/UniProt Q3T186
type: UnificationXref
id: Q3T186
db: UniProt

Reference/UniProt Q3T189
type: UnificationXref
id: Q3T189
db: UniProt

Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

Reference/ChEBI CHEBI 32816
type: UnificationXref
id: CHEBI:32816
db: ChEBI

Protein/17672 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Isocitrate dehydrogenase [NADP] cytoplasmic
stoichiometric coefficient: 2.0

Mitochondrial pyruvate carrier 1
type: Protein
entity reference: Mitochondrial pyruvate carrier 1

Xylulose 5-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Xylulose 5-phosphate

Reference/ChEBI CHEBI 16108
type: UnificationXref
id: CHEBI:16108
db: ChEBI

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Glyceric acid 1,3-biphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Glyceric acid 1,3-biphosphate

Reference/HMDB HMDB0000618
type: UnificationXref
id: HMDB0000618
db: HMDB

ChemicalStructure/PW C001870
type: ChemicalStructure
structure format: SMILES
structure data: OC[C@@H](OP(O)(O)=O)C(O)=O

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Reference/HMDB HMDB0000868
type: UnificationXref
id: HMDB0000868
db: HMDB

ChemicalStructure/PW C000986
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000500
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(N)=O)C(O)=O

Citric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Citric acid

Reference/ChemSpider 193317
type: UnificationXref
id: 193317
db: ChemSpider

Malate dehydrogenase, cytoplasmic
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Malate dehydrogenase, cytoplasmic

Protein/14876 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-oxoglutarate dehydrogenase, mitochondrial
stoichiometric coefficient: 1.0

Reference/BioCyc GAP
type: UnificationXref
id: GAP
db: BioCyc

Reference/PubChem-compound 1060
type: UnificationXref
id: 1060
db: PubChem-compound

Protein/14874 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
stoichiometric coefficient: 1.0

ReactionCatalysis137125
type: Catalysis
controller: Glucose-6-phosphate 1-dehydrogenase
controlled: 1.1.1.49
control type: ACTIVATION

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

ReactionCatalysis137126
type: Catalysis
controller: Isocitrate dehydrogenase [NADP] cytoplasmic
controlled: 1.1.1.42
control type: ACTIVATION

ReactionCatalysis137122
type: Catalysis
controller: Aconitate hydratase, mitochondrial
controlled: 4.2.1.3
control type: ACTIVATION

ReactionCatalysis137123
type: Catalysis
controller: Cytoplasmic aconitate hydratase
controlled: 4.2.1.3
control type: ACTIVATION

ReactionCatalysis137124
type: Catalysis
controller: 6-phosphogluconolactonase
controlled: 3.1.1.31
control type: ACTIVATION

Reference/KEGG Compound C00661
type: UnificationXref
id: C00661
db: KEGG Compound

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Unknown
type: ProteinReference
organism: Bos taurus

Protein/14871 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000641
type: UnificationXref
id: HMDB0000641
db: HMDB

2.3.3.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000063 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000148 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
right: Coenzyme A
right: Citric acid
spontaneous: false
EC number: 2.3.3.1
left: Acetyl-CoA
left: Water
left: Oxalacetic acid
name: Acetyl-CoA + Oxalacetic acid + Water → Citric acid + Coenzyme A
conversion direction: LEFT_TO_RIGHT

1.2.4.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Mitochondrial Matrix/Stoichiometry/1.0
right: Acetyl-CoA
right: Carbon dioxide
right: NADH
spontaneous: false
EC number: 1.2.4.1
left: Pyruvic acid
left: Coenzyme A
left: NAD
name: Coenzyme A + NAD + Pyruvic acid → Acetyl-CoA + Carbon dioxide + NADH
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc UBIQUINONE-10
type: UnificationXref
id: UBIQUINONE-10
db: BioCyc

Reference/CAS 4300-28-1
type: UnificationXref
id: 4300-28-1
db: CAS

Reference/UniProt Q3ZCG2
type: UnificationXref
id: Q3ZCG2
db: UniProt