Reference/CAS 2457-80-9
type: UnificationXref
id: 2457-80-9
db: CAS

Reference/KEGG Compound C00315
type: UnificationXref
id: C00315
db: KEGG Compound

Reference/CAS 71-44-3
type: UnificationXref
id: 71-44-3
db: CAS

Compound/PW C000970 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Spermine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6262
type: UnificationXref
id: 6262
db: PubChem-compound

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

S-Adenosylmethioninamine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: S-Adenosylmethioninamine

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/ChemSpider 13837702
type: UnificationXref
id: 13837702
db: ChemSpider

Reference/HMDB HMDB0001185
type: UnificationXref
id: HMDB0001185
db: HMDB

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Spermidine synthase
type: Protein
cellular location: Cytoplasm
entity reference: Spermidine synthase

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/UniProt P09057
type: UnificationXref
id: P09057
db: UniProt

Reference/PubChem-compound 6137
type: UnificationXref
id: 6137
db: PubChem-compound

Reference/BioCyc S-ADENOSYLMETHIONINAMINE
type: UnificationXref
id: S-ADENOSYLMETHIONINAMINE
db: BioCyc

Water
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Water

Reference/CAS 124-20-9
type: UnificationXref
id: 124-20-9
db: CAS

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Reference/ChEBI CHEBI 15729
type: UnificationXref
id: CHEBI:15729
db: ChEBI

S-Adenosylmethionine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24762165
xref: Reference/KEGG Compound C00019
xref: Reference/ChemSpider 31983
xref: Reference/ChEBI CHEBI 15414
xref: Reference/CAS 485-80-3
xref: Reference/BioCyc S-ADENOSYLMETHIONINE
xref: Reference/HMDB HMDB0001185
chemical formula: C15H23N6O5S
molecular weight: 399.14505
structure: ChemicalStructure/PW C000921

Reference/UniProt P13444
type: UnificationXref
id: P13444
db: UniProt

Compound/PW C000921 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylmethionine
stoichiometric coefficient: 1.0

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Protein/7814 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: S-adenosylmethionine synthase isoform type-1
stoichiometric coefficient: 2.0

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

ChemicalStructure/PW C000548
type: ChemicalStructure
structure format: SMILES
structure data: CSCC[C@H](N)C(O)=O

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Carbon dioxide
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Carbon dioxide

Reference/PubChem-compound 439176
type: UnificationXref
id: 439176
db: PubChem-compound

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Ornithine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Ornithine

Compound/PW C000910 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5'-Methylthioadenosine
stoichiometric coefficient: 1.0

Reference/CAS 70-26-8
type: UnificationXref
id: 70-26-8
db: CAS

Reference/CAS 485-80-3
type: UnificationXref
id: 485-80-3
db: CAS

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: O4P
molecular weight: 94.95342
structure: ChemicalStructure/PW C001104

Reference/ChemSpider 6026
type: UnificationXref
id: 6026
db: ChemSpider

Compound/PW C000783 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylmethioninamine
stoichiometric coefficient: 1.0

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Ornithine
type: SmallMolecule
entity reference: Ornithine
name: SubPathwayOutput

Compound/PW C000921 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylmethionine
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001414
type: UnificationXref
id: HMDB0001414
db: HMDB

Putrescine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Putrescine

Rattus norvegicus
type: BioSource
xref: Reference/TAXONOMY 10116

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

ChemicalStructure/PW C001092
type: ChemicalStructure
structure format: SMILES
structure data: NCCCCN

Protein/7815 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Methionine adenosyltransferase 2 subunit beta
stoichiometric coefficient: 1.0

SubPathwayInteraction108533
type: Interaction
name: SubPathway108533Reaction
name: SubPathwayReaction
participant: Ornithine

S-Adenosylmethioninamine
type: SmallMolecule
cellular location: Cytosol
entity reference: S-Adenosylmethioninamine

Reference/SMPDB SMP0087308
type: UnificationXref
id: SMP0087308
db: SMPDB

Ornithine
type: SmallMoleculeReference
xref: Reference/CAS 70-26-8
xref: Reference/HMDB HMDB0000214
xref: Reference/PubChem-compound 6262
xref: Reference/KEGG Compound C00077
xref: Reference/BioCyc L-ORNITHINE
xref: Reference/ChemSpider 6026
xref: Reference/ChEBI CHEBI 15729
chemical formula: C5H12N2O2
molecular weight: 132.08987
structure: ChemicalStructure/PW C000140

Reference/ChEBI CHEBI 17148
type: UnificationXref
id: CHEBI:17148
db: ChEBI

Reference/ChEBI CHEBI 16610
type: UnificationXref
id: CHEBI:16610
db: ChEBI

ChemicalStructure/PW C000921
type: ChemicalStructure
structure format: SMILES

Protein/15849 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Ornithine decarboxylase
stoichiometric coefficient: 2.0

Carbon dioxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbon dioxide

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Spermine synthase
type: Complex
component stoichiometry: Protein/15846 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Spermine synthase

Reference/HMDB HMDB0000696
type: UnificationXref
id: HMDB0000696
db: HMDB

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])([O-])=O

Reference/HMDB HMDB0000214
type: UnificationXref
id: HMDB0000214
db: HMDB

S-adenosylmethionine synthase isoform type-1
type: Protein
cellular location: Cytoplasm
entity reference: S-adenosylmethionine synthase isoform type-1

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/CAS 110-60-1
type: UnificationXref
id: 110-60-1
db: CAS

Reference/ChEBI CHEBI 15414
type: UnificationXref
id: CHEBI:15414
db: ChEBI

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Spermidine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Spermidine

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/ChemSpider 388321
type: UnificationXref
id: 388321
db: ChemSpider

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/PathWhiz PW088327
type: UnificationXref
id: PW088327
db: PathWhiz

ChemicalStructure/PW C000140
type: ChemicalStructure
structure format: SMILES
structure data: NCCC[C@H](N)C(O)=O

Reference/UniProt Q5U2R0
type: UnificationXref
id: Q5U2R0
db: UniProt

Reference/KEGG Compound C00019
type: UnificationXref
id: C00019
db: KEGG Compound

S-adenosylmethionine decarboxylase proenzyme
type: Protein
cellular location: Cytosol
entity reference: S-adenosylmethionine decarboxylase proenzyme

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15625
type: UnificationXref
id: CHEBI:15625
db: ChEBI

Reference/ChEBI CHEBI 15746
type: UnificationXref
id: CHEBI:15746
db: ChEBI

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine triphosphate

Reference/BioCyc S-ADENOSYLMETHIONINE
type: UnificationXref
id: S-ADENOSYLMETHIONINE
db: BioCyc

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Reference/KEGG Compound C00134
type: UnificationXref
id: C00134
db: KEGG Compound

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: O7P2
molecular weight: 173.91193
structure: ChemicalStructure/PW C000170

4.1.1.50
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000783 Cytosol/Stoichiometry/1.0
right: Carbon dioxide
right: S-Adenosylmethioninamine
spontaneous: false
EC number: 4.1.1.50
left: Hydrogen Ion
left: S-Adenosylmethionine
name: Hydrogen Ion + S-Adenosylmethionine → Carbon dioxide + S-Adenosylmethioninamine
conversion direction: LEFT_TO_RIGHT

Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

4.1.1.17
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001092 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000140 Cytoplasm/Stoichiometry/1.0
right: Carbon dioxide
right: Putrescine
spontaneous: false
EC number: 4.1.1.17
left: Ornithine
name: Ornithine → Carbon dioxide + Putrescine
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/UniProt Q99MI5
type: UnificationXref
id: Q99MI5
db: UniProt

2.5.1.22
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000970 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000971 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000783 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000910 Cytoplasm/Stoichiometry/1.0
right: 5'-Methylthioadenosine
right: Spermine
spontaneous: false
EC number: 2.5.1.22
left: S-Adenosylmethioninamine
left: Spermidine
name: S-Adenosylmethioninamine + Spermidine → 5'-Methylthioadenosine + Spermine
conversion direction: LEFT_TO_RIGHT

2.5.1.16
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000971 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001092 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000783 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000910 Cytoplasm/Stoichiometry/1.0
right: Spermidine
right: 5'-Methylthioadenosine
spontaneous: false
EC number: 2.5.1.16
left: S-Adenosylmethioninamine
left: Putrescine
name: Putrescine + S-Adenosylmethioninamine → 5'-Methylthioadenosine + Spermidine
conversion direction: LEFT_TO_RIGHT

Spermidine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00315
xref: Reference/HMDB HMDB0001257
xref: Reference/ChEBI CHEBI 16610
xref: Reference/CAS 124-20-9
xref: Reference/BioCyc SPERMIDINE
xref: Reference/PubChem-compound 1102
xref: Reference/ChemSpider 1071
chemical formula: C7H19N3
molecular weight: 145.1579
structure: ChemicalStructure/PW C000971

Spermidine and Spermine Biosynthesis
type: Pathway
pathway order: PathwayEnzymeReaction/2114134
pathway order: PathwayEnzymeReaction/2114133
pathway order: PathwayEnzymeReaction/2114132
pathway order: PathwayEnzymeReaction/2114131
pathway order: PathwayEnzymeReaction/2114130
pathway order: PathwaySubPathway/108533
pathway component: ReactionCatalysis137477
pathway component: ReactionCatalysis137478
pathway component: ReactionCatalysis137479
pathway component: Arginine and Proline Metabolism
pathway component: 4.1.1.50
pathway component: 4.1.1.17
pathway component: ReactionCatalysis2649
pathway component: ReactionCatalysis137476
pathway component: 2.5.1.22
pathway component: 2.5.1.16
pathway component: 2.5.1.6
xref: Reference/PathWhiz PW088327
xref: Reference/SMPDB SMP0087308
organism: Rattus norvegicus

Spermine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001256
xref: Reference/CAS 71-44-3
xref: Reference/BioCyc SPERMINE
xref: Reference/ChEBI CHEBI 15746
xref: Reference/PubChem-compound 1103
xref: Reference/ChemSpider 1072
xref: Reference/KEGG Compound C00750
chemical formula: C10H26N4
molecular weight: 202.21574
structure: ChemicalStructure/PW C000970

Reference/PubChem-compound 439415
type: UnificationXref
id: 439415
db: PubChem-compound

Compound/PW C000548 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Methionine
stoichiometric coefficient: 1.0

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/CAS 22365-13-5
type: UnificationXref
id: 22365-13-5
db: CAS

ChemicalStructure/PW C000910
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 1102
type: UnificationXref
id: 1102
db: PubChem-compound

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/BioCyc MET
type: UnificationXref
id: MET
db: BioCyc

Reference/PubChem-compound 1103
type: UnificationXref
id: 1103
db: PubChem-compound

Spermidine synthase
type: Complex
component stoichiometry: Protein/15841 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Spermidine synthase

Arginine and Proline Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108533
pathway component: SubPathwayInteraction108533
xref: Reference/PathWhiz PW000010
xref: Reference/SMPDB SMP0000020
name: SubPathway

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

ReactionCatalysis2649
type: Catalysis
controller: S-adenosylmethionine synthase
controlled: 2.5.1.6
control type: ACTIVATION

Ornithine decarboxylase
type: Protein
cellular location: Cytoplasm
entity reference: Ornithine decarboxylase

S-adenosylmethionine decarboxylase proenzyme
type: ProteinReference
xref: Reference/UniProt P17708
organism: Rattus norvegicus

L-Methionine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000696
xref: Reference/ChEBI CHEBI 16643
xref: Reference/KEGG Compound C00073
xref: Reference/CAS 63-68-3
xref: Reference/BioCyc MET
xref: Reference/PubChem-compound 6137
xref: Reference/ChemSpider 5907
chemical formula: C5H11NO2S
molecular weight: 149.05106
structure: ChemicalStructure/PW C000548

Protein/15841 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Spermidine synthase
stoichiometric coefficient: 2.0

Reference/BioCyc PUTRESCINE
type: UnificationXref
id: PUTRESCINE
db: BioCyc

Methionine adenosyltransferase 2 subunit beta
type: ProteinReference
xref: Reference/UniProt Q5U2R0
organism: Rattus norvegicus

S-adenosylmethionine synthase isoform type-1
type: ProteinReference
xref: Reference/UniProt P13444
organism: Rattus norvegicus

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Reference/TAXONOMY 10116
type: UnificationXref
id: 10116
db: TAXONOMY

ChemicalStructure/PW C000971
type: ChemicalStructure
structure format: SMILES
structure data: NCCCCNCCCN

ChemicalStructure/PW C000970
type: ChemicalStructure
structure format: SMILES
structure data: NCCCNCCCCNCCCN

Compound/PW C001316 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/BioCyc 5-METHYLTHIOADENOSINE
type: UnificationXref
id: 5-METHYLTHIOADENOSINE
db: BioCyc

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])(=O)OP([O-])([O-])=O

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Protein/15846 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Spermine synthase
stoichiometric coefficient: 2.0

Reference/ChemSpider 1072
type: UnificationXref
id: 1072
db: ChemSpider

Reference/ChemSpider 1071
type: UnificationXref
id: 1071
db: ChemSpider

Reference/KEGG Compound C01137
type: UnificationXref
id: C01137
db: KEGG Compound

S-Adenosylmethionine
type: SmallMolecule
cellular location: Cytosol
entity reference: S-Adenosylmethionine

Reference/BioCyc SPERMINE
type: UnificationXref
id: SPERMINE
db: BioCyc

Reference/KEGG Compound C00170
type: UnificationXref
id: C00170
db: KEGG Compound

Reference/ChEBI CHEBI 17509
type: UnificationXref
id: CHEBI:17509
db: ChEBI

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Reference/ChemSpider 388529
type: UnificationXref
id: 388529
db: ChemSpider

Putrescine
type: SmallMoleculeReference
xref: Reference/CAS 110-60-1
xref: Reference/BioCyc PUTRESCINE
xref: Reference/ChEBI CHEBI 17148
xref: Reference/HMDB HMDB0001414
xref: Reference/ChemSpider 13837702
xref: Reference/KEGG Compound C00134
xref: Reference/PubChem-compound 1045
chemical formula: C4H12N2
molecular weight: 88.10005
structure: ChemicalStructure/PW C001092

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

5'-Methylthioadenosine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 5'-Methylthioadenosine

Spermine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Spermine

L-Methionine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Methionine

Reference/CAS 63-68-3
type: UnificationXref
id: 63-68-3
db: CAS

Reference/ChemSpider 5907
type: UnificationXref
id: 5907
db: ChemSpider

Reference/SMPDB SMP0000020
type: UnificationXref
id: SMP0000020
db: SMPDB

Reference/ChEBI CHEBI 16643
type: UnificationXref
id: CHEBI:16643
db: ChEBI

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Pyrophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pyrophosphate

Reference/HMDB HMDB0001256
type: UnificationXref
id: HMDB0001256
db: HMDB

Reference/HMDB HMDB0001257
type: UnificationXref
id: HMDB0001257
db: HMDB

Reference/KEGG Compound C00073
type: UnificationXref
id: C00073
db: KEGG Compound

Reference/UniProt Q3MIE9
type: UnificationXref
id: Q3MIE9
db: UniProt

S-Adenosylmethioninamine
type: SmallMoleculeReference
xref: Reference/CAS 22365-13-5
xref: Reference/ChEBI CHEBI 15625
xref: Reference/HMDB HMDB0000988
xref: Reference/ChemSpider 388529
xref: Reference/PubChem-compound 439415
xref: Reference/KEGG Compound C01137
xref: Reference/BioCyc S-ADENOSYLMETHIONINAMINE
chemical formula: C14H23N6O3S
molecular weight: 355.15524
structure: ChemicalStructure/PW C000783

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChemSpider 31983
type: UnificationXref
id: 31983
db: ChemSpider

Reference/KEGG Compound C00077
type: UnificationXref
id: C00077
db: KEGG Compound

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Reference/UniProt P17708
type: UnificationXref
id: P17708
db: UniProt

Reference/KEGG Compound C00750
type: UnificationXref
id: C00750
db: KEGG Compound

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

5'-Methylthioadenosine
type: SmallMoleculeReference
xref: Reference/CAS 2457-80-9
xref: Reference/PubChem-compound 439176
xref: Reference/KEGG Compound C00170
xref: Reference/ChEBI CHEBI 17509
xref: Reference/HMDB HMDB0001173
xref: Reference/BioCyc 5-METHYLTHIOADENOSINE
xref: Reference/ChemSpider 388321
chemical formula: C11H15N5O3S
molecular weight: 297.08957
structure: ChemicalStructure/PW C000910

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/PathWhiz PW000010
type: UnificationXref
id: PW000010
db: PathWhiz

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphate

Reference/PubChem-compound 1045
type: UnificationXref
id: 1045
db: PubChem-compound

S-adenosylmethionine synthase
type: Complex
component stoichiometry: Protein/7815 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/7814 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: S-adenosylmethionine synthase isoform type-1
component: Methionine adenosyltransferase 2 subunit beta

Ornithine decarboxylase
type: Complex
component stoichiometry: Protein/15849 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Ornithine decarboxylase

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

ChemicalStructure/PW C000783
type: ChemicalStructure
structure format: SMILES

S-adenosylmethionine decarboxylase proenzyme
type: Complex
component stoichiometry: Protein/15855 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: S-adenosylmethionine decarboxylase proenzyme

2.5.1.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000921 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000548 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
right: S-Adenosylmethionine
right: Phosphate
right: Pyrophosphate
spontaneous: false
EC number: 2.5.1.6
left: L-Methionine
left: Water
left: Adenosine triphosphate
name: Adenosine triphosphate + L-Methionine + Water → Phosphate + Pyrophosphate + S-Adenosylmethionine
conversion direction: LEFT_TO_RIGHT

Methionine adenosyltransferase 2 subunit beta
type: Protein
cellular location: Cytoplasm
entity reference: Methionine adenosyltransferase 2 subunit beta

ReactionCatalysis137477
type: Catalysis
controller: Spermine synthase
controlled: 2.5.1.22
control type: ACTIVATION

ReactionCatalysis137478
type: Catalysis
controller: Ornithine decarboxylase
controlled: 4.1.1.17
control type: ACTIVATION

ReactionCatalysis137479
type: Catalysis
controller: S-adenosylmethionine decarboxylase proenzyme
controlled: 4.1.1.50
control type: ACTIVATION

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

ReactionCatalysis137476
type: Catalysis
controller: Spermidine synthase
controlled: 2.5.1.16
control type: ACTIVATION

Reference/HMDB HMDB0000988
type: UnificationXref
id: HMDB0000988
db: HMDB

Protein/15855 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: S-adenosylmethionine decarboxylase proenzyme
stoichiometric coefficient: 4.0

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Spermidine synthase
type: ProteinReference
xref: Reference/UniProt Q99MI5
organism: Rattus norvegicus

Spermine synthase
type: Protein
cellular location: Cytoplasm
entity reference: Spermine synthase

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Reference/BioCyc SPERMIDINE
type: UnificationXref
id: SPERMIDINE
db: BioCyc

Compound/PW C001316 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Compound/PW C001092 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Putrescine
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Compound/PW C000140 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ornithine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 24762165
type: UnificationXref
id: 24762165
db: PubChem-compound

Compound/PW C000971 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Spermidine
stoichiometric coefficient: 1.0

Compound/PW C000783 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylmethioninamine
stoichiometric coefficient: 1.0

S-Adenosylmethionine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: S-Adenosylmethionine

Reference/HMDB HMDB0001173
type: UnificationXref
id: HMDB0001173
db: HMDB

Reference/BioCyc L-ORNITHINE
type: UnificationXref
id: L-ORNITHINE
db: BioCyc

Ornithine decarboxylase
type: ProteinReference
xref: Reference/UniProt P09057
organism: Rattus norvegicus

Spermine synthase
type: ProteinReference
xref: Reference/UniProt Q3MIE9
organism: Rattus norvegicus