S-Adenosylmethionine
type: SmallMolecule
cellular location: Mitochondrion
entity reference: S-Adenosylmethionine

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Compound/PW C017005 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ubiquinone-6
stoichiometric coefficient: 1.0

2-Hexaprenyl-6-methoxy-1,4-benzoquinone
type: SmallMolecule
cellular location: Mitochondrion
entity reference: 2-Hexaprenyl-6-methoxy-1,4-benzoquinone

Reference/ChemSpider 132
type: UnificationXref
id: 132
db: ChemSpider

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/UniProt Q4G064
type: UnificationXref
id: Q4G064
db: UniProt

Reference/HMDB HMDB0001063
type: UnificationXref
id: HMDB0001063
db: HMDB

Reference/HMDB HMDB0001185
type: UnificationXref
id: HMDB0001185
db: HMDB

Ubiquinone-6
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Ubiquinone-6

4-Hydroxybenzoic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: 4-Hydroxybenzoic acid

Compound/PW C007741 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: All-trans-hexaprenyl diphosphate
stoichiometric coefficient: 1.0

Compound/PW C002946 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Hexaprenyl-6-methoxyphenol
stoichiometric coefficient: 1.0

3-Hexaprenyl-4,5-Dihydroxybenzoic acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C05200
xref: Reference/ChemSpider 4444330
xref: Reference/ChEBI CHEBI 18081
xref: Reference/PubChem-compound 5280760
xref: Reference/CAS 63975-40-6
xref: Reference/HMDB HMDB0001063
xref: Reference/BioCyc 3-HEXAPRENYL-45-DIHYDROXYBENZOATE
chemical formula: C37H54O4
molecular weight: 562.4022
structure: ChemicalStructure/PW C000838

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Compound/PW C000838 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Hexaprenyl-4,5-Dihydroxybenzoic acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 4444377
type: UnificationXref
id: 4444377
db: ChemSpider

Ubiquinone-6
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 52971
xref: Reference/CAS 1065-31-2
xref: Reference/ChemSpider 4446657
xref: Reference/HMDB HMDB0036062
xref: Reference/PubChem-compound 98470
xref: Reference/KEGG Compound C17568
chemical formula: C39H58O4
molecular weight: 590.43353
structure: ChemicalStructure/PW C017005

S-Adenosylmethionine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24762165
xref: Reference/KEGG Compound C00019
xref: Reference/ChemSpider 31983
xref: Reference/ChEBI CHEBI 15414
xref: Reference/CAS 485-80-3
xref: Reference/BioCyc S-ADENOSYLMETHIONINE
xref: Reference/HMDB HMDB0001185
chemical formula: C15H23N6O5S
molecular weight: 399.14505
structure: ChemicalStructure/PW C000921

3-Hexaprenyl-4,5-Dihydroxybenzoic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: 3-Hexaprenyl-4,5-Dihydroxybenzoic acid

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Reference/ChemSpider 4444374
type: UnificationXref
id: 4444374
db: ChemSpider

Reference/ChemSpider 4444375
type: UnificationXref
id: 4444375
db: ChemSpider

Reference/HMDB HMDB0036062
type: UnificationXref
id: HMDB0036062
db: HMDB

Reference/ChemSpider 4444376
type: UnificationXref
id: 4444376
db: ChemSpider

2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

Reference/CAS 66551-60-8
type: UnificationXref
id: 66551-60-8
db: CAS

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Compound/PW C002945 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Hexaprenyl-4-hydroxybenzoic acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Reference/CAS 1065-31-2
type: UnificationXref
id: 1065-31-2
db: CAS

ChemicalStructure/PW C007741
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5280828
type: UnificationXref
id: 5280828
db: PubChem-compound

Hydrogen Ion
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Hydrogen Ion

Reference/PubChem-compound 5280826
type: UnificationXref
id: 5280826
db: PubChem-compound

Reference/PubChem-compound 5280827
type: UnificationXref
id: 5280827
db: PubChem-compound

Reference/PubChem-compound 5280825
type: UnificationXref
id: 5280825
db: PubChem-compound

5-demethoxyubiquinone hydroxylase, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: 5-demethoxyubiquinone hydroxylase, mitochondrial

Reference/KEGG Compound C17568
type: UnificationXref
id: C17568
db: KEGG Compound

Ubiquinone biosynthesis O-methyltransferase, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Ubiquinone biosynthesis O-methyltransferase, mitochondrial

Reference/PubChem-compound 135
type: UnificationXref
id: 135
db: PubChem-compound

Reference/BioCyc ADENOSYL-HOMO-CYS
type: UnificationXref
id: ADENOSYL-HOMO-CYS
db: BioCyc

Reference/CAS 485-80-3
type: UnificationXref
id: 485-80-3
db: CAS

Compound/PW C000143 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Reference/UniProt Q499N4
type: UnificationXref
id: Q499N4
db: UniProt

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reference/ChEBI CHEBI 30763
type: UnificationXref
id: CHEBI:30763
db: ChEBI

Rattus norvegicus
type: BioSource
xref: Reference/TAXONOMY 10116

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

Mitochondrion
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005739

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H29N7O17P3
molecular weight: 744.08325
structure: ChemicalStructure/PW C000143

4-Hydroxybenzoic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 135
xref: Reference/ChEBI CHEBI 30763
xref: Reference/HMDB HMDB0000500
xref: Reference/CAS 99-96-7
xref: Reference/ChemSpider 132
xref: Reference/KEGG Compound C00156
chemical formula: C7H6O3
molecular weight: 138.0317
structure: ChemicalStructure/PW C000382

4-hydroxybenzoate polyprenyltransferase, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: 4-hydroxybenzoate polyprenyltransferase, mitochondrial

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Reference/SMPDB SMP0087310
type: UnificationXref
id: SMP0087310
db: SMPDB

Reference/KEGG Compound C05804
type: UnificationXref
id: C05804
db: KEGG Compound

Reference/KEGG Compound C05803
type: UnificationXref
id: C05803
db: KEGG Compound

2-Hexaprenyl-3-methyl-6-methoxy-1,4 benzoquinone
type: SmallMolecule
cellular location: Mitochondrion
entity reference: 2-Hexaprenyl-3-methyl-6-methoxy-1,4 benzoquinone

ChemicalStructure/PW C017005
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C05805
type: UnificationXref
id: C05805
db: KEGG Compound

ChemicalStructure/PW C000921
type: ChemicalStructure
structure format: SMILES

Reference/CAS 979-92-0
type: UnificationXref
id: 979-92-0
db: CAS

Reference/KEGG Compound C05802
type: UnificationXref
id: C05802
db: KEGG Compound

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Compound/PW C000382 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-Hydroxybenzoic acid
stoichiometric coefficient: 1.0

S-Adenosylhomocysteine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 25246222
xref: Reference/ChemSpider 388301
xref: Reference/BioCyc ADENOSYL-HOMO-CYS
xref: Reference/CAS 979-92-0
xref: Reference/KEGG Compound C00021
xref: Reference/ChEBI CHEBI 16680
xref: Reference/HMDB HMDB0000939
chemical formula: C14H20N6O5S
molecular weight: 384.12158
structure: ChemicalStructure/PW C000749

Reference/ChEBI CHEBI 27752
type: UnificationXref
id: CHEBI:27752
db: ChEBI

Water
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Water

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Reference/KEGG Compound C13425
type: UnificationXref
id: C13425
db: KEGG Compound

Reaction849
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000838 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002945 Mitochondrion/Stoichiometry/1.0
right: 3-Hexaprenyl-4,5-Dihydroxybenzoic acid
spontaneous: true
left: 3-Hexaprenyl-4-hydroxybenzoic acid
name: 3-Hexaprenyl-4-hydroxybenzoic acid → 3-Hexaprenyl-4,5-Dihydroxybenzoic acid
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/ChEBI CHEBI 15414
type: UnificationXref
id: CHEBI:15414
db: ChEBI

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/BioCyc 3-HEXAPRENYL-45-DIHYDROXYBENZOATE
type: UnificationXref
id: 3-HEXAPRENYL-45-DIHYDROXYBENZOATE
db: BioCyc

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Compound/PW C000749 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylhomocysteine
stoichiometric coefficient: 1.0

2-Hexaprenyl-6-methoxyphenol
type: SmallMolecule
cellular location: Mitochondrion
entity reference: 2-Hexaprenyl-6-methoxyphenol

Compound/PW C001065 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Compound/PW C040034 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/PathWhiz PW088329
type: UnificationXref
id: PW088329
db: PathWhiz

ChemicalStructure/PW C000382
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C1=CC=C(O)C=C1

Reference/ChEBI CHEBI 28711
type: UnificationXref
id: CHEBI:28711
db: ChEBI

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Compound/PW C000170 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reaction147259
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002949 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000749 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C017005 Mitochondrion/Stoichiometry/1.0
right: Ubiquinone-6
right: S-Adenosylhomocysteine
spontaneous: false
left: 2-Hexaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone
left: S-Adenosylmethionine
name: 2-Hexaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone + S-Adenosylmethionine → S-Adenosylhomocysteine + Ubiquinone-6
conversion direction: LEFT_TO_RIGHT

Reaction147258
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001065 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002949 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002948 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Mitochondrion/Stoichiometry/1.0
right: 2-Hexaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone
right: Water
right: NADP
spontaneous: false
left: NADPH
left: 2-Hexaprenyl-3-methyl-6-methoxy-1,4 benzoquinone
left: Hydrogen Ion
left: Oxygen
name: 2-Hexaprenyl-3-methyl-6-methoxy-1,4 benzoquinone + Hydrogen Ion + NADPH + Oxygen → 2-Hexaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone + NADP + Water
conversion direction: LEFT_TO_RIGHT

2.1.1.201
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000749 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002947 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002948 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921 Mitochondrion/Stoichiometry/1.0
right: 2-Hexaprenyl-3-methyl-6-methoxy-1,4 benzoquinone
right: S-Adenosylhomocysteine
spontaneous: false
EC number: 2.1.1.201
left: S-Adenosylmethionine
left: 2-Hexaprenyl-6-methoxy-1,4-benzoquinone
name: 2-Hexaprenyl-6-methoxy-1,4-benzoquinone + S-Adenosylmethionine → 2-Hexaprenyl-3-methyl-6-methoxy-1,4 benzoquinone + S-Adenosylhomocysteine
conversion direction: LEFT_TO_RIGHT

1.14.13.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001065 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002947 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002946 Mitochondrion/Stoichiometry/1.0
right: Water
right: 2-Hexaprenyl-6-methoxy-1,4-benzoquinone
spontaneous: false
EC number: 1.14.13.-
left: 2-Hexaprenyl-6-methoxyphenol
left: Oxygen
name: 2-Hexaprenyl-6-methoxyphenol + Oxygen → 2-Hexaprenyl-6-methoxy-1,4-benzoquinone + Water
conversion direction: LEFT_TO_RIGHT

Reaction147255
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000749 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000838 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000777 Mitochondrion/Stoichiometry/1.0
right: 3-Hexaprenyl-4-hydroxy-5-methoxybenzoic acid
right: S-Adenosylhomocysteine
spontaneous: false
left: S-Adenosylmethionine
left: 3-Hexaprenyl-4,5-Dihydroxybenzoic acid
name: 3-Hexaprenyl-4,5-Dihydroxybenzoic acid + S-Adenosylmethionine → 3-Hexaprenyl-4-hydroxy-5-methoxybenzoic acid + S-Adenosylhomocysteine
conversion direction: LEFT_TO_RIGHT

2.5.1.39
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000170 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007741 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000382 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002945 Mitochondrion/Stoichiometry/1.0
right: Pyrophosphate
right: 3-Hexaprenyl-4-hydroxybenzoic acid
spontaneous: false
EC number: 2.5.1.39
left: 4-Hydroxybenzoic acid
left: All-trans-hexaprenyl diphosphate
name: 4-Hydroxybenzoic acid + All-trans-hexaprenyl diphosphate → 3-Hexaprenyl-4-hydroxybenzoic acid + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Reference/KEGG Compound C00019
type: UnificationXref
id: C00019
db: KEGG Compound

Ubiquinone Biosynthesis
type: Pathway
pathway order: PathwayEnzymeReaction/2114146
pathway order: PathwayEnzymeReaction/2114145
pathway order: PathwayEnzymeReaction/2114144
pathway order: PathwayEnzymeReaction/2114149
pathway order: PathwayEnzymeReaction/2114148
pathway order: PathwayEnzymeReaction/2114147
pathway order: PathwayEnzymeReaction/2114151
pathway order: PathwayEnzymeReaction/2114150
pathway component: Reaction849
pathway component: ReactionCatalysis137488
pathway component: ReactionCatalysis137489
pathway component: ReactionCatalysis137486
pathway component: ReactionCatalysis137487
pathway component: Reaction147259
pathway component: Reaction147258
pathway component: 2.1.1.201
pathway component: ReactionCatalysis137491
pathway component: 1.14.13.-
pathway component: Reaction147255
pathway component: Reaction850
pathway component: 2.5.1.39
pathway component: ReactionCatalysis137490
xref: Reference/PathWhiz PW088329
xref: Reference/SMPDB SMP0087310
organism: Rattus norvegicus

Reference/BioCyc ALL-TRANS-HEXAPRENYL-DIPHOSPHATE
type: UnificationXref
id: ALL-TRANS-HEXAPRENYL-DIPHOSPHATE
db: BioCyc

Reference/ChEBI CHEBI 16835
type: UnificationXref
id: CHEBI:16835
db: ChEBI

Reference/BioCyc S-ADENOSYLMETHIONINE
type: UnificationXref
id: S-ADENOSYLMETHIONINE
db: BioCyc

Oxygen
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Oxygen

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: O7P2
molecular weight: 173.91193
structure: ChemicalStructure/PW C000170

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Reference/UniProt O08887
type: UnificationXref
id: O08887
db: UniProt

Reaction850
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002946 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000777 Mitochondrion/Stoichiometry/1.0
right: 2-Hexaprenyl-6-methoxyphenol
spontaneous: true
left: 3-Hexaprenyl-4-hydroxy-5-methoxybenzoic acid
name: 3-Hexaprenyl-4-hydroxy-5-methoxybenzoic acid → 2-Hexaprenyl-6-methoxyphenol
conversion direction: LEFT_TO_RIGHT

2-Hexaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone
type: SmallMolecule
cellular location: Mitochondrion
entity reference: 2-Hexaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/ChemSpider 388301
type: UnificationXref
id: 388301
db: ChemSpider

Reference/KEGG Compound C00021
type: UnificationXref
id: C00021
db: KEGG Compound

Reference/KEGG Compound C01230
type: UnificationXref
id: C01230
db: KEGG Compound

Reference/GENE ONTOLOGY GO 0005739
type: UnificationXref
id: GO:0005739
db: GENE ONTOLOGY

Reference/UniProt Q68FU7
type: UnificationXref
id: Q68FU7
db: UniProt

Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/CAS 65848-03-5
type: UnificationXref
id: 65848-03-5
db: CAS

Reference/TAXONOMY 10116
type: UnificationXref
id: 10116
db: TAXONOMY

Reference/KEGG Compound C00156
type: UnificationXref
id: C00156
db: KEGG Compound

Compound/PW C000777 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Hexaprenyl-4-hydroxy-5-methoxybenzoic acid
stoichiometric coefficient: 1.0

All-trans-hexaprenyl diphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 5280413
xref: Reference/ChemSpider 4444089
xref: Reference/BioCyc ALL-TRANS-HEXAPRENYL-DIPHOSPHATE
xref: Reference/ChEBI CHEBI 17528
xref: Reference/KEGG Compound C01230
xref: Reference/HMDB HMDB0012188
chemical formula: C30H52O7P2
molecular weight: 586.31885
structure: ChemicalStructure/PW C007741

Reference/PubChem-compound 5280760
type: UnificationXref
id: 5280760
db: PubChem-compound

S-Adenosylhomocysteine
type: SmallMolecule
cellular location: Mitochondrion
entity reference: S-Adenosylhomocysteine

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])(=O)OP([O-])([O-])=O

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Compound/PW C000921 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylmethionine
stoichiometric coefficient: 1.0

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/HMDB HMDB0000939
type: UnificationXref
id: HMDB0000939
db: HMDB

Reference/ChEBI CHEBI 31116
type: UnificationXref
id: CHEBI:31116
db: ChEBI

4-hydroxybenzoate polyprenyltransferase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q499N4
organism: Rattus norvegicus

Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q68FU7
organism: Rattus norvegicus

2-Hexaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone
type: SmallMoleculeReference
xref: Reference/ChemSpider 4444377
xref: Reference/KEGG Compound C05805
xref: Reference/PubChem-compound 5280828
xref: Reference/HMDB HMDB0006820
chemical formula: C38H56O4
molecular weight: 576.41785
structure: ChemicalStructure/PW C002949

Reference/PubChem-compound 11954011
type: UnificationXref
id: 11954011
db: PubChem-compound

Ubiquinone biosynthesis O-methyltransferase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q642D7
organism: Rattus norvegicus

3-Hexaprenyl-4-hydroxybenzoic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 11954011
xref: Reference/ChEBI CHEBI 31116
xref: Reference/HMDB HMDB0006816
xref: Reference/ChemSpider 10128306
xref: Reference/CAS 65848-03-5
xref: Reference/KEGG Compound C13425
chemical formula: C37H54O3
molecular weight: 546.4073
structure: ChemicalStructure/PW C002945

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

2-Hexaprenyl-6-methoxyphenol
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0006817
xref: Reference/ChemSpider 4444374
xref: Reference/KEGG Compound C05802
xref: Reference/PubChem-compound 5280825
xref: Reference/ChEBI CHEBI 1109
chemical formula: C37H56O2
molecular weight: 532.42804
structure: ChemicalStructure/PW C002946

All-trans-hexaprenyl diphosphate
type: SmallMolecule
cellular location: Mitochondrion
entity reference: All-trans-hexaprenyl diphosphate

2-Hexaprenyl-6-methoxy-1,4-benzoquinone
type: SmallMoleculeReference
xref: Reference/BioCyc 2-HEXAPRENYL-6-METHOXY-14-BENZOQUINOL
xref: Reference/ChEBI CHEBI 27752
xref: Reference/KEGG Compound C05803
xref: Reference/ChemSpider 4444375
xref: Reference/PubChem-compound 5280826
xref: Reference/HMDB HMDB0006818
chemical formula: C37H54O3
molecular weight: 546.4073
structure: ChemicalStructure/PW C002947

2-Hexaprenyl-3-methyl-6-methoxy-1,4 benzoquinone
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 28711
xref: Reference/KEGG Compound C05804
xref: Reference/ChemSpider 4444376
xref: Reference/PubChem-compound 5280827
xref: Reference/HMDB HMDB0006819
chemical formula: C38H56O3
molecular weight: 560.423
structure: ChemicalStructure/PW C002948

Reference/UniProt Q642D7
type: UnificationXref
id: Q642D7
db: UniProt

Reference/HMDB HMDB0006816
type: UnificationXref
id: HMDB0006816
db: HMDB

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Reference/HMDB HMDB0006817
type: UnificationXref
id: HMDB0006817
db: HMDB

3-Hexaprenyl-4-hydroxybenzoic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: 3-Hexaprenyl-4-hydroxybenzoic acid

Reference/ChEBI CHEBI 1109
type: UnificationXref
id: CHEBI:1109
db: ChEBI

Reference/ChemSpider 4444089
type: UnificationXref
id: 4444089
db: ChemSpider

5-demethoxyubiquinone hydroxylase, mitochondrial
type: ProteinReference
xref: Reference/UniProt O08887
organism: Rattus norvegicus

ChemicalStructure/PW C000838
type: ChemicalStructure
structure format: SMILES

3-Hexaprenyl-4-hydroxy-5-methoxybenzoic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 5280776
xref: Reference/ChEBI CHEBI 16835
xref: Reference/HMDB HMDB0000977
xref: Reference/CAS 66551-60-8
xref: Reference/ChemSpider 4444339
xref: Reference/KEGG Compound C05313
chemical formula: C38H56O4
molecular weight: 576.41785
structure: ChemicalStructure/PW C000777

Reference/CAS 99-96-7
type: UnificationXref
id: 99-96-7
db: CAS

2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q4G064
organism: Rattus norvegicus

Reference/HMDB HMDB0006818
type: UnificationXref
id: HMDB0006818
db: HMDB

Reference/HMDB HMDB0006819
type: UnificationXref
id: HMDB0006819
db: HMDB

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Reference/PubChem-compound 5280413
type: UnificationXref
id: 5280413
db: PubChem-compound

Reference/PubChem-compound 5280776
type: UnificationXref
id: 5280776
db: PubChem-compound

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

3-Hexaprenyl-4-hydroxy-5-methoxybenzoic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: 3-Hexaprenyl-4-hydroxy-5-methoxybenzoic acid

Reference/CAS 63975-40-6
type: UnificationXref
id: 63975-40-6
db: CAS

Reference/HMDB HMDB0006820
type: UnificationXref
id: HMDB0006820
db: HMDB

Reference/BioCyc 2-HEXAPRENYL-6-METHOXY-14-BENZOQUINOL
type: UnificationXref
id: 2-HEXAPRENYL-6-METHOXY-14-BENZOQUINOL
db: BioCyc

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChemSpider 31983
type: UnificationXref
id: 31983
db: ChemSpider

Reference/ChemSpider 4446657
type: UnificationXref
id: 4446657
db: ChemSpider

ChemicalStructure/PW C002946
type: ChemicalStructure
structure format: SMILES
structure data: COC1=CC=CC(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C1O

ChemicalStructure/PW C002947
type: ChemicalStructure
structure format: SMILES
structure data: COC1=CC(=O)C=C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)C1=O

ChemicalStructure/PW C002948
type: ChemicalStructure
structure format: SMILES
structure data: COC1=CC(=O)C(C)=C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)C1=O

ChemicalStructure/PW C002949
type: ChemicalStructure
structure format: SMILES
structure data: COC1=C(O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C(=O)C1=O

ChemicalStructure/PW C002945
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Reference/ChemSpider 10128306
type: UnificationXref
id: 10128306
db: ChemSpider

ReactionCatalysis137491
type: Catalysis
controller: Ubiquinone biosynthesis O-methyltransferase, mitochondrial
controlled: Reaction147259
control type: ACTIVATION

Reference/PubChem-compound 98470
type: UnificationXref
id: 98470
db: PubChem-compound

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Compound/PW C000146 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

ReactionCatalysis137490
type: Catalysis
controller: 5-demethoxyubiquinone hydroxylase, mitochondrial
controlled: Reaction147258
control type: ACTIVATION

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Pyrophosphate
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Pyrophosphate

Compound/PW C002949 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Hexaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/HMDB HMDB0000977
type: UnificationXref
id: HMDB0000977
db: HMDB

ChemicalStructure/PW C000777
type: ChemicalStructure
structure format: SMILES
structure data: COC1=CC(=CC(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C1O)C(O)=O

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

NADP
type: SmallMolecule
cellular location: Mitochondrion
entity reference: NADP

Reference/HMDB HMDB0000500
type: UnificationXref
id: HMDB0000500
db: HMDB

Reference/ChEBI CHEBI 18081
type: UnificationXref
id: CHEBI:18081
db: ChEBI

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Reference/ChEBI CHEBI 17528
type: UnificationXref
id: CHEBI:17528
db: ChEBI

Reference/ChemSpider 4444330
type: UnificationXref
id: 4444330
db: ChemSpider

ChemicalStructure/PW C000749
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 25246222
type: UnificationXref
id: 25246222
db: PubChem-compound

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Compound/PW C002948 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Hexaprenyl-3-methyl-6-methoxy-1,4 benzoquinone
stoichiometric coefficient: 1.0

Reference/ChemSpider 4444339
type: UnificationXref
id: 4444339
db: ChemSpider

ReactionCatalysis137488
type: Catalysis
controller: Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial
controlled: 1.14.13.-
control type: ACTIVATION

ReactionCatalysis137489
type: Catalysis
controller: 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
controlled: 2.1.1.201
control type: ACTIVATION

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

NADPH
type: SmallMolecule
cellular location: Mitochondrion
entity reference: NADPH

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

ReactionCatalysis137486
type: Catalysis
controller: 4-hydroxybenzoate polyprenyltransferase, mitochondrial
controlled: 2.5.1.39
control type: ACTIVATION

ReactionCatalysis137487
type: Catalysis
controller: Ubiquinone biosynthesis O-methyltransferase, mitochondrial
controlled: Reaction147255
control type: ACTIVATION

Reference/ChEBI CHEBI 16680
type: UnificationXref
id: CHEBI:16680
db: ChEBI

Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

Reference/HMDB HMDB0012188
type: UnificationXref
id: HMDB0012188
db: HMDB

Reference/KEGG Compound C05313
type: UnificationXref
id: C05313
db: KEGG Compound

Reference/PubChem-compound 24762165
type: UnificationXref
id: 24762165
db: PubChem-compound

Reference/ChEBI CHEBI 52971
type: UnificationXref
id: CHEBI:52971
db: ChEBI

Reference/KEGG Compound C05200
type: UnificationXref
id: C05200
db: KEGG Compound

Compound/PW C002947 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Hexaprenyl-6-methoxy-1,4-benzoquinone
stoichiometric coefficient: 1.0