NADPH oxidase 3
type: ProteinReference
xref: Reference/UniProt Q672K1
organism: Rattus norvegicus

Reference/CAS 7722-84-1
type: UnificationXref
id: 7722-84-1
db: CAS

1.11.1.8
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001783 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007784 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/2.0
participant stoichiometry: Protein/17632 Cytosol/Stoichiometry/1.0
right: Thyroglobulin
right: Water
spontaneous: false
EC number: 1.11.1.8
left: Iodide
left: Hydrogen peroxide
left: Thyroglobulin
name: Hydrogen peroxide + Iodide + [thyroglobulin]-3-iodo-L-tyrosine → 2 Water + [thyroglobulin]-3,5-diiodo-L-tyrosine
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 28015
type: UnificationXref
id: 28015
db: ChemSpider

Reference/PathWhiz PW088381
type: UnificationXref
id: PW088381
db: PathWhiz

Reference/HMDB HMDB0012238
type: UnificationXref
id: HMDB0012238
db: HMDB

1.11.1.8
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001783 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/17632 Cytosol/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/2.0
participant stoichiometry: Protein/17632 Cytosol/Stoichiometry/1.0
right: Thyroglobulin
right: Water
spontaneous: false
EC number: 1.11.1.8
left: Hydrogen peroxide
left: Thyroglobulin
name: Hydrogen peroxide + 2 [thyroglobulin]-3,5-diiodo-L-tyrosine → 2 Water + [thyroglobulin]-3,5,3'-triiodo-L-thyronine + [thyroglobulin]-aminoacrylate
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 923
type: UnificationXref
id: 923
db: PubChem-compound

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/GENE ONTOLOGY GO 0030139
type: UnificationXref
id: GO:0030139
db: GENE ONTOLOGY

Reference/TAXONOMY 10116
type: UnificationXref
id: 10116
db: TAXONOMY

Reference/CAS 20461-54-5
type: UnificationXref
id: 20461-54-5
db: CAS

Reference/ChemSpider 899
type: UnificationXref
id: 899
db: ChemSpider

Sodium
type: SmallMolecule
entity reference: Sodium

Reference/PubChem-compound 25201348
type: UnificationXref
id: 25201348
db: PubChem-compound

Reference/HMDB HMDB0003125
type: UnificationXref
id: HMDB0003125
db: HMDB

Reference/BioCyc HYDROGEN-PEROXIDE
type: UnificationXref
id: HYDROGEN-PEROXIDE
db: BioCyc

ChemicalStructure/PW C001783
type: ChemicalStructure
structure format: SMILES
structure data: OO

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/GENE ONTOLOGY GO 0070382
type: UnificationXref
id: GO:0070382
db: GENE ONTOLOGY

Thyroglobulin
type: ProteinReference
xref: Reference/UniProt Q9JM94
organism: Rattus norvegicus

Thyroid peroxidase
type: ProteinReference
xref: Reference/UniProt P14650
organism: Rattus norvegicus

Reference/BioCyc L-THYROXINE
type: UnificationXref
id: L-THYROXINE
db: BioCyc

Compound/PW C000169 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thyroxine
stoichiometric coefficient: 1.0

Compound/PW C000181 Endocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: Liothyronine
stoichiometric coefficient: 1.0

NADPH oxidase 4
type: ProteinReference
xref: Reference/UniProt Q99M78
organism: Rattus norvegicus

Reference/SMPDB SMP0087362
type: UnificationXref
id: SMP0087362
db: SMPDB

Reference/UniProt Q672K1
type: UnificationXref
id: Q672K1
db: UniProt

Reference/BioCyc CPD-387
type: UnificationXref
id: CPD-387
db: BioCyc

ChemicalStructure/PW C000458
type: ChemicalStructure
structure format: SMILES
structure data: [Na+]

Reference/UniProt Q99M78
type: UnificationXref
id: Q99M78
db: UniProt

Reference/ChEBI CHEBI 16382
type: UnificationXref
id: CHEBI:16382
db: ChEBI

Unknown
type: Protein
entity reference: Unknown

Thyroid Hormone Synthesis
type: Pathway
pathway order: PathwayEnzymeReaction/2115344
pathway order: PathwayEnzymeReaction/2115343
pathway order: PathwayEnzymeReaction/2115342
pathway order: PathwayTransport/2115354
pathway order: PathwayTransport/2115353
pathway order: PathwayTransport/2115345
pathway order: PathwayTransport/2115356
pathway order: PathwayTransport/2115355
pathway order: PathwayTransport/2115347
pathway order: PathwayTransport/2115358
pathway order: PathwayTransport/2115346
pathway order: PathwayTransport/2115357
pathway order: PathwayTransport/2115349
pathway order: PathwayTransport/2115348
pathway order: PathwayTransport/2115350
pathway order: PathwayTransport/2115352
pathway order: PathwaySubPathway/108707
pathway order: PathwayTransport/2115351
pathway order: PathwayEnzymeReaction/2115341
pathway component: 1.11.1.8
pathway component: ReactionCatalysis168777
pathway component: ReactionCatalysis168776
pathway component: ReactionCatalysis168775
pathway component: ReactionCatalysis168774
pathway component: Transport8074
pathway component: Transport8075
pathway component: Transport8076
pathway component: Transport8077
pathway component: Transport8078
pathway component: Transport8079
pathway component: TransportCatalysis1084
pathway component: Transport8072
pathway component: TransportCatalysis1083
pathway component: Transport8073
pathway component: Thyroglobulin secretion
pathway component: Transport8085
pathway component: Transport8080
pathway component: Transport8081
pathway component: Transport8082
pathway component: Transport8083
pathway component: Transport8084
xref: Reference/SMPDB SMP0087362
xref: Reference/PathWhiz PW088381
organism: Rattus norvegicus

Reference/KEGG Compound C02465
type: UnificationXref
id: C02465
db: KEGG Compound

Transport8085
type: Transport
participant stoichiometry: Protein/17632 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/17632 Endocytic Vesicle/Stoichiometry/1.0
right: Thyroglobulin
spontaneous: false
left: Thyroglobulin
name: Thyroglobulin with L-Tyrosine (↔) Transport: Rattus norvegicus, Cell, Endocytic Vesicle to Rattus norvegicus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0000265
type: UnificationXref
id: HMDB0000265
db: HMDB

Reference/ChemSpider 763
type: UnificationXref
id: 763
db: ChemSpider

Protein/17646 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dual oxidase 2
stoichiometric coefficient: 1.0

Cytochrome b-245 light chain
type: ProteinReference
xref: Reference/UniProt Q9ER27
organism: Rattus norvegicus

Compound/PW C001420 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 2.0

Transport8080
type: Transport
participant stoichiometry: Compound/PW C000181 Endocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000181 Cytosol/Stoichiometry/1.0
right: Liothyronine
spontaneous: false
left: Liothyronine
name: Liothyronine (→) Transport: Rattus norvegicus, Cell, Endocytic Vesicle to Rattus norvegicus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Dual oxidase 1
type: ProteinReference
xref: Reference/UniProt Q8CIY2
organism: Rattus norvegicus

Transport8081
type: Transport
participant stoichiometry: Compound/PW C000181 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000181 Cytosol/Stoichiometry/1.0
right: Liothyronine
spontaneous: false
left: Liothyronine
name: Liothyronine (→) Transport: Rattus norvegicus, Cell, Cytosol to Rattus norvegicus, Cell, Exocytic Vesicle
conversion direction: LEFT_TO_RIGHT

Dual oxidase 2
type: ProteinReference
xref: Reference/UniProt Q811Y4
organism: Rattus norvegicus

Transport8082
type: Transport
participant stoichiometry: Protein/17632 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/17632 Endocytic Vesicle/Stoichiometry/1.0
right: Thyroglobulin
spontaneous: false
left: Thyroglobulin
name: Thyroglobulin with L-Tyrosine (←) Transport: Rattus norvegicus, Cell, Endocytic Vesicle to Rattus norvegicus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000181
type: ChemicalStructure
structure format: SMILES

Transport8083
type: Transport
participant stoichiometry: Protein/17632 Nucleus/Stoichiometry/1.0
participant stoichiometry: Protein/17632 Exocytic Vesicle/Stoichiometry/1.0
right: Thyroglobulin
spontaneous: false
left: Thyroglobulin
name: Thyroglobulin with L-Tyrosine (←) Transport: Rattus norvegicus, Cell, Exocytic Vesicle to Rattus norvegicus, Cell, Nucleus
conversion direction: LEFT_TO_RIGHT

Reference/CAS 17341-25-2
type: UnificationXref
id: 17341-25-2
db: CAS

Transport8084
type: Transport
participant stoichiometry: Protein/17632 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Protein/17632 Cytosol/Stoichiometry/1.0
right: Thyroglobulin
spontaneous: false
left: Thyroglobulin
name: Thyroglobulin with L-Tyrosine (←) Transport: Rattus norvegicus, Cell, Cytosol to Rattus norvegicus, Cell, Exocytic Vesicle
conversion direction: LEFT_TO_RIGHT

Thyroid peroxidase
type: Complex
component stoichiometry: Protein/17646 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/17645 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/17633 Cytosol/Stoichiometry/2.0
component stoichiometry: Protein/17643 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/17639 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/17649 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: NADPH oxidase 4
component: Thyroid peroxidase
component: NADPH oxidase 3
component: Dual oxidase 1
component: Cytochrome b-245 light chain
component: Dual oxidase 2

Thyroid peroxidase
type: Protein
cellular location: Cytosol
entity reference: Thyroid peroxidase

Reference/PubChem-compound 784
type: UnificationXref
id: 784
db: PubChem-compound

Reference/ChEBI CHEBI 18258
type: UnificationXref
id: CHEBI:18258
db: ChEBI

Endocytic Vesicle
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0030139

Compound/PW C000169 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thyroxine
stoichiometric coefficient: 1.0

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/UniProt Q9ER27
type: UnificationXref
id: Q9ER27
db: UniProt

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/CAS 6893-02-3
type: UnificationXref
id: 6893-02-3
db: CAS

Protein/17632 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thyroglobulin
stoichiometric coefficient: 1.0

Reference/UniProt P14650
type: UnificationXref
id: P14650
db: UniProt

Exocytic Vesicle
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0070382

Compound/PW C007784 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Iodide
stoichiometric coefficient: 1.0

Thyroglobulin
type: Protein
cellular location: Endocytic Vesicle
entity reference: Thyroglobulin

Liothyronine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Liothyronine

Reference/KEGG Compound C01829
type: UnificationXref
id: C01829
db: KEGG Compound

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Compound/PW C000458/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Reference/ChemSpider 5614
type: UnificationXref
id: 5614
db: ChemSpider

Reference/PubChem-compound 30165
type: UnificationXref
id: 30165
db: PubChem-compound

Reference/ChEBI CHEBI 16240
type: UnificationXref
id: CHEBI:16240
db: ChEBI

1.11.1.8
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001783 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007784 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/17632 Cytosol/Stoichiometry/1.0
right: Thyroglobulin
right: Water
spontaneous: false
EC number: 1.11.1.8
left: Iodide
left: Hydrogen peroxide
left: Thyroglobulin
name: Hydrogen peroxide + Iodide + Thyroglobulin with L-Tyrosine → Water + [thyroglobulin]-3-iodo-L-tyrosine
conversion direction: LEFT_TO_RIGHT

1.11.1.8
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001783 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007784 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/2.0
participant stoichiometry: Protein/17632 Cytosol/Stoichiometry/1.0
right: Thyroglobulin
right: Water
spontaneous: false
EC number: 1.11.1.8
left: Iodide
left: Hydrogen peroxide
left: Thyroglobulin
name: Hydrogen peroxide + Iodide + [thyroglobulin]-3,5,3'-triiodo-L-thyronine → 2 Water + [thyroglobulin]-thyroxine
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000169
type: ChemicalStructure
structure format: SMILES

Liothyronine
type: SmallMolecule
cellular location: Endocytic Vesicle
entity reference: Liothyronine

Rattus norvegicus
type: BioSource
xref: Reference/TAXONOMY 10116

Dual oxidase 1
type: Protein
cellular location: Cytosol
entity reference: Dual oxidase 1

Compound/PW C000181 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Liothyronine
stoichiometric coefficient: 1.0

Iodide
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Iodide

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Protein/17643 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cytochrome b-245 light chain
stoichiometric coefficient: 1.0

NADPH oxidase 4
type: Protein
cellular location: Cytosol
entity reference: NADPH oxidase 4

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/UniProt Q8CIY2
type: UnificationXref
id: Q8CIY2
db: UniProt

Compound/PW C001783 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen peroxide
stoichiometric coefficient: 1.0

Thyroglobulin
type: Protein
cellular location: Exocytic Vesicle
entity reference: Thyroglobulin

Protein/17645 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dual oxidase 1
stoichiometric coefficient: 1.0

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Hydrogen peroxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen peroxide

Sodium
type: SmallMolecule
cellular location: Cytosol
entity reference: Sodium

Compound/PW C000458 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Thyroxine
type: SmallMolecule
cellular location: Endocytic Vesicle
entity reference: Thyroxine

Thyroxine
type: SmallMolecule
cellular location: Cytosol
entity reference: Thyroxine

Compound/PW C000181 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Liothyronine
stoichiometric coefficient: 1.0

Iodide
type: SmallMoleculeReference
xref: Reference/ChemSpider 28015
xref: Reference/HMDB HMDB0012238
xref: Reference/BioCyc CPD-387
xref: Reference/KEGG Compound C00708
xref: Reference/PubChem-compound 30165
xref: Reference/ChEBI CHEBI 16382
xref: Reference/CAS 20461-54-5
chemical formula: I
molecular weight: 126.904465
structure: ChemicalStructure/PW C007784

TransportCatalysis1084
type: Catalysis
controller: Unknown
controlled: Transport8073
control type: ACTIVATION

Compound/PW C007784 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Iodide
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

TransportCatalysis1083
type: Catalysis
controller: Sodium/iodide cotransporter
controlled: Transport8072
control type: ACTIVATION

Liothyronine
type: SmallMolecule
cellular location: Exocytic Vesicle
entity reference: Liothyronine

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

SubPathwayInteraction108707
type: Interaction
name: SubPathwayReaction
name: SubPathway108707Reaction
participant: Thyroglobulin

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/KEGG Compound C01330
type: UnificationXref
id: C01330
db: KEGG Compound

Reference/PubChem-compound 5920
type: UnificationXref
id: 5920
db: PubChem-compound

Reference/HMDB HMDB0000588
type: UnificationXref
id: HMDB0000588
db: HMDB

Compound/PW C000169 Exocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thyroxine
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005634
type: UnificationXref
id: GO:0005634
db: GENE ONTOLOGY

Protein/17632 Exocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thyroglobulin
stoichiometric coefficient: 1.0

Iodide
type: SmallMolecule
cellular location: Cytosol
entity reference: Iodide

Reference/UniProt Q9JM94
type: UnificationXref
id: Q9JM94
db: UniProt

Dual oxidase 2
type: Protein
cellular location: Cytosol
entity reference: Dual oxidase 2

Thyroglobulin
type: Protein
cellular location: Cytosol
entity reference: Thyroglobulin

Protein/17632 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thyroglobulin
stoichiometric coefficient: 1.0

Protein/17639 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH oxidase 3
stoichiometric coefficient: 1.0

Compound/PW C000169 Endocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thyroxine
stoichiometric coefficient: 1.0

Reference/BioCyc LIOTHYRONINE
type: UnificationXref
id: LIOTHYRONINE
db: BioCyc

ReactionCatalysis168777
type: Catalysis
controller: Thyroid peroxidase
controlled: 1.11.1.8
control type: ACTIVATION

ReactionCatalysis168776
type: Catalysis
controller: Thyroid peroxidase
controlled: 1.11.1.8
control type: ACTIVATION

Unknown
type: ProteinReference

Thyroxine
type: SmallMoleculeReference
xref: Reference/CAS 51-48-9
xref: Reference/PubChem-compound 25201348
xref: Reference/HMDB HMDB0000248
xref: Reference/ChemSpider 5614
xref: Reference/KEGG Compound C01829
xref: Reference/BioCyc L-THYROXINE
xref: Reference/ChEBI CHEBI 18332
chemical formula: C15H11I4NO4
molecular weight: 776.6867
structure: ChemicalStructure/PW C000169

ReactionCatalysis168775
type: Catalysis
controller: Thyroid peroxidase
controlled: 1.11.1.8
control type: ACTIVATION

ReactionCatalysis168774
type: Catalysis
controller: Thyroid peroxidase
controlled: 1.11.1.8
control type: ACTIVATION

Sodium/iodide cotransporter
type: Protein
entity reference: Sodium/iodide cotransporter

Liothyronine
type: SmallMolecule
cellular location: Cytosol
entity reference: Liothyronine

Thyroglobulin
type: Protein
cellular location: Nucleus
entity reference: Thyroglobulin
name: SubPathwayOutput

Thyroxine
type: SmallMolecule
cellular location: Exocytic Vesicle
entity reference: Thyroxine

Protein/17649 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH oxidase 4
stoichiometric coefficient: 1.0

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/ChEBI CHEBI 18332
type: UnificationXref
id: CHEBI:18332
db: ChEBI

Protein/17632 Endocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thyroglobulin
stoichiometric coefficient: 1.0

Transport8074
type: Transport
participant stoichiometry: Protein/17632 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Protein/17632 Cytosol/Stoichiometry/1.0
right: Thyroglobulin
spontaneous: false
left: Thyroglobulin
name: [thyroglobulin]-3,5,3'-triiodo-L-thyronine (→) Transport: Rattus norvegicus, Extracellular Space to Rattus norvegicus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Thyroglobulin
type: Protein
cellular location: Extracellular Space
entity reference: Thyroglobulin

Transport8075
type: Transport
participant stoichiometry: Protein/17632 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Protein/17632 Cytosol/Stoichiometry/1.0
right: Thyroglobulin
spontaneous: false
left: Thyroglobulin
name: [thyroglobulin]-thyroxine (→) Transport: Rattus norvegicus, Extracellular Space to Rattus norvegicus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/CAS 51-48-9
type: UnificationXref
id: 51-48-9
db: CAS

Transport8076
type: Transport
participant stoichiometry: Compound/PW C000169 Endocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000169 Cytosol/Stoichiometry/1.0
right: Thyroxine
spontaneous: false
left: Thyroxine
name: Thyroxine (→) Transport: Rattus norvegicus, Cell, Endocytic Vesicle to Rattus norvegicus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport8077
type: Transport
participant stoichiometry: Compound/PW C000169 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000169 Cytosol/Stoichiometry/1.0
right: Thyroxine
spontaneous: false
left: Thyroxine
name: Thyroxine (→) Transport: Rattus norvegicus, Cell, Cytosol to Rattus norvegicus, Cell, Exocytic Vesicle
conversion direction: LEFT_TO_RIGHT

Transport8078
type: Transport
participant stoichiometry: Compound/PW C000169 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000169 Extracellular Space/Stoichiometry/1.0
right: Thyroxine
spontaneous: false
left: Thyroxine
name: Thyroxine (→) Transport: Rattus norvegicus, Cell, Exocytic Vesicle to Rattus norvegicus, Cell, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Hydrogen peroxide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003125
xref: Reference/PubChem-compound 784
xref: Reference/ChemSpider 763
xref: Reference/CAS 7722-84-1
xref: Reference/BioCyc HYDROGEN-PEROXIDE
xref: Reference/ChEBI CHEBI 16240
xref: Reference/KEGG Compound C00027
chemical formula: H2O2
molecular weight: 34.005478
structure: ChemicalStructure/PW C001783

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Transport8079
type: Transport
participant stoichiometry: Compound/PW C000181 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000181 Exocytic Vesicle/Stoichiometry/1.0
right: Liothyronine
spontaneous: false
left: Liothyronine
name: Liothyronine (→) Transport: Rattus norvegicus, Cell, Exocytic Vesicle to Rattus norvegicus, Cell, Extracellular Space
conversion direction: LEFT_TO_RIGHT

NADPH oxidase 3
type: Protein
cellular location: Cytosol
entity reference: NADPH oxidase 3

Iodide
type: SmallMolecule
entity reference: Iodide

ChemicalStructure/PW C007784
type: ChemicalStructure
structure format: SMILES
structure data: [I-]

Reference/ChemSpider 5707
type: UnificationXref
id: 5707
db: ChemSpider

Compound/PW C000181 Exocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: Liothyronine
stoichiometric coefficient: 1.0

Reference/UniProt Q811Y4
type: UnificationXref
id: Q811Y4
db: UniProt

Transport8072
type: Transport
participant stoichiometry: Compound/PW C000458/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007784 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007784/Stoichiometry/1.0
right: Iodide
right: Sodium
spontaneous: false
left: Iodide
left: Sodium
name: Sodium (→), Iodide (→) Transport: Rattus norvegicus, Blood Vessel to Rattus norvegicus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Thyroxine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Thyroxine

Nucleus
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005634

Transport8073
type: Transport
participant stoichiometry: Compound/PW C007784 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007784 Cytosol/Stoichiometry/1.0
right: Iodide
spontaneous: false
left: Iodide
name: Iodide (→) Transport: Rattus norvegicus, Cell, Cytosol to Rattus norvegicus, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Thyroglobulin secretion
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108707
pathway component: SubPathwayInteraction108707
name: SubPathway

Sodium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000588
xref: Reference/PubChem-compound 923
xref: Reference/KEGG Compound C01330
xref: Reference/ChEBI CHEBI 29101
xref: Reference/ChemSpider 899
xref: Reference/CAS 17341-25-2
chemical formula: Na
molecular weight: 22.989769
structure: ChemicalStructure/PW C000458

Protein/17633 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Thyroid peroxidase
stoichiometric coefficient: 2.0

Reference/UniProt Q63008
type: UnificationXref
id: Q63008
db: UniProt

Cytochrome b-245 light chain
type: Protein
cellular location: Cytosol
entity reference: Cytochrome b-245 light chain

Reference/KEGG Compound C00027
type: UnificationXref
id: C00027
db: KEGG Compound

Compound/PW C007784/Stoichiometry/1.0
type: Stoichiometry
physical entity: Iodide
stoichiometric coefficient: 1.0

Liothyronine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000265
xref: Reference/CAS 6893-02-3
xref: Reference/ChEBI CHEBI 18258
xref: Reference/BioCyc LIOTHYRONINE
xref: Reference/PubChem-compound 5920
xref: Reference/ChemSpider 5707
xref: Reference/KEGG Compound C02465
chemical formula: C15H12I3NO4
molecular weight: 650.79004
structure: ChemicalStructure/PW C000181

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/HMDB HMDB0000248
type: UnificationXref
id: HMDB0000248
db: HMDB

Protein/17632 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thyroglobulin
stoichiometric coefficient: 1.0

Protein/17632 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Thyroglobulin
stoichiometric coefficient: 2.0

Reference/KEGG Compound C00708
type: UnificationXref
id: C00708
db: KEGG Compound

Reference/ChEBI CHEBI 29101
type: UnificationXref
id: CHEBI:29101
db: ChEBI

Sodium/iodide cotransporter
type: ProteinReference
xref: Reference/UniProt Q63008