Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Ammonia Recycling
type: Pathway
pathway order: PathwayEnzymeReaction/2115587
pathway order: PathwaySubPathway/108770
pathway order: PathwayEnzymeReaction/2115586
pathway order: PathwaySubPathway/108771
pathway order: PathwayEnzymeReaction/2115585
pathway order: PathwaySubPathway/108772
pathway order: PathwayEnzymeReaction/2115584
pathway order: PathwaySubPathway/108773
pathway order: PathwayEnzymeReaction/2115589
pathway order: PathwayEnzymeReaction/2115588
pathway order: PathwaySubPathway/108767
pathway order: PathwaySubPathway/108768
pathway order: PathwaySubPathway/108769
pathway order: PathwayTransport/2115591
pathway order: PathwayEnzymeReaction/2115590
pathway order: PathwayEnzymeReaction/2115583
pathway order: PathwayEnzymeReaction/2115582
pathway order: PathwayEnzymeReaction/2115581
pathway order: PathwayEnzymeReaction/2115580
pathway component: 4.3.1.3
pathway component: 2.1.2.10
pathway component: ReactionCatalysis138426
pathway component: 1.8.1.4
pathway component: 1.4.4.2
pathway component: 1.4.1.3
pathway component: ReactionCatalysis138466
pathway component: Glutamate Metabolism
pathway component: ReactionCatalysis138581
pathway component: ReactionCatalysis138580
pathway component: ReactionCatalysis138461
pathway component: ReactionCatalysis138582
pathway component: Urea Cycle
pathway component: Transport8095
pathway component: Citric Acid Cycle
pathway component: ReactionCatalysis138578
pathway component: 6.3.5.4
pathway component: ReactionCatalysis138577
pathway component: ReactionCatalysis138456
pathway component: ReactionCatalysis138579
pathway component: 6.3.1.2
pathway component: 3.5.1.2
pathway component: ReactionCatalysis138455
pathway component: Aspartate Metabolism
pathway component: Histidine Metabolism
pathway component: Glycine and Serine Metabolism
pathway component: Reaction148260
pathway component: Reaction148261
pathway component: 6.3.4.16
xref: Reference/SMPDB SMP0087375
xref: Reference/PathWhiz PW088394
organism: Drosophila melanogaster

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Compound/PW C000500 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16134
type: UnificationXref
id: CHEBI:16134
db: ChEBI

Reference/PubChem-compound 6267
type: UnificationXref
id: 6267
db: PubChem-compound

L-Histidine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Histidine

Reference/ChEBI CHEBI 30314
type: UnificationXref
id: CHEBI:30314
db: ChEBI

Compound/PW C000035 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonia
stoichiometric coefficient: 1.0

L-Aspartic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Aspartic acid

Compound/PW C001034 Mitochondrial Matrix/Stoichiometry/2.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 2.0

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

Reference/ChemSpider 50
type: UnificationXref
id: 50
db: ChemSpider

Transport8095
type: Transport
participant stoichiometry: Compound/PW C000035 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Mitochondrial Matrix/Stoichiometry/1.0
right: Ammonia
spontaneous: false
left: Ammonia
name: Ammonia (→) Transport: Drosophila melanogaster, Cell, Cytoplasm to Drosophila melanogaster, Cell, Mitochondrial Matrix
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 20506
type: UnificationXref
id: CHEBI:20506
db: ChEBI

Reference/PubChem-compound 53481912
type: UnificationXref
id: 53481912
db: PubChem-compound

Reference/ChEBI CHEBI 17115
type: UnificationXref
id: CHEBI:17115
db: ChEBI

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Dihydrolipoyl dehydrogenase
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Dihydrolipoyl dehydrogenase

Reference/ChemSpider 18714427
type: UnificationXref
id: 18714427
db: ChemSpider

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Reference/UniProt Q9VCF7
type: UnificationXref
id: Q9VCF7
db: UniProt

Tetrahydrofolic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Tetrahydrofolic acid

Reference/PathWhiz PW000043
type: UnificationXref
id: PW000043
db: PathWhiz

Reference/ChemSpider 5746
type: UnificationXref
id: 5746
db: ChemSpider

Reference/ChemSpider 5745
type: UnificationXref
id: 5745
db: ChemSpider

Reference/BioCyc ASN
type: UnificationXref
id: ASN
db: BioCyc

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/BioCyc L-ASPARTATE
type: UnificationXref
id: L-ASPARTATE
db: BioCyc

Compound/PW C000862 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbamoyl phosphate
stoichiometric coefficient: 1.0

Reference/PathWhiz PW000162
type: UnificationXref
id: PW000162
db: PathWhiz

Compound/PW C001034 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 439175
type: UnificationXref
id: 439175
db: PubChem-compound

Compound/PW C001441 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoric acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

L-Glutamic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: L-Glutamic acid
name: SubPathwayInput

Reference/ChemSpider 5736
type: UnificationXref
id: 5736
db: ChemSpider

Adenosine monophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine monophosphate

Reference/PubChem-compound 6274
type: UnificationXref
id: 6274
db: PubChem-compound

Carbon dioxide
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Carbon dioxide

SubPathwayInteraction108767
type: Interaction
name: SubPathwayReaction
name: SubPathway108767Reaction
participant: L-Serine

SubPathwayInteraction108768
type: Interaction
name: SubPathway108768Reaction
name: SubPathwayReaction
participant: L-Histidine

Reference/PathWhiz PW000157
type: UnificationXref
id: PW000157
db: PathWhiz

SubPathwayInteraction108769
type: Interaction
name: SubPathwayReaction
name: SubPathway108769Reaction
participant: Pyruvic acid

Reference/BioCyc METHYLENE-THF
type: UnificationXref
id: METHYLENE-THF
db: BioCyc

Protein/15256 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: CG8129, isoform B
stoichiometric coefficient: 2.0

Reference/KEGG Compound C00101
type: UnificationXref
id: C00101
db: KEGG Compound

ChemicalStructure/PW C007757
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCCCC(S)CCS

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

SubPathwayInteraction108773
type: Interaction
name: SubPathwayReaction
name: SubPathway108773Reaction
participant: L-Aspartic acid

Drosophila melanogaster
type: BioSource
xref: Reference/TAXONOMY 7227

Glycine dehydrogenase [decarboxylating], mitochondrial
type: Complex
component stoichiometry: Protein/15265 Mitochondrial Matrix/Stoichiometry/2.0
cellular location: Mitochondrial Matrix
component: Glycine cleavage system P protein

Reference/HMDB HMDB0001096
type: UnificationXref
id: HMDB0001096
db: HMDB

SubPathwayInteraction108770
type: Interaction
name: SubPathway108770Reaction
name: SubPathwayReaction
participant: Carbamoyl phosphate

SubPathwayInteraction108771
type: Interaction
name: SubPathway108771Reaction
name: SubPathwayReaction
participant: Glycine

SubPathwayInteraction108772
type: Interaction
name: SubPathwayReaction
name: SubPathway108772Reaction
participant: L-Glutamic acid

Reference/ChemSpider 643824
type: UnificationXref
id: 643824
db: ChemSpider

Compound/PW C000120 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Serine
stoichiometric coefficient: 1.0

Reference/ChemSpider 5886
type: UnificationXref
id: 5886
db: ChemSpider

L-Glutamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000641
xref: Reference/ChEBI CHEBI 18050
xref: Reference/ChemSpider 5746
xref: Reference/BioCyc GLN
xref: Reference/KEGG Compound C00064
xref: Reference/PubChem-compound 5961
xref: Reference/CAS 56-85-9
chemical formula: C5H10N2O3
molecular weight: 146.06914
structure: ChemicalStructure/PW C000500

Carbamoyl phosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 278
xref: Reference/BioCyc CARBAMOYL-P
xref: Reference/ChemSpider 272
xref: Reference/HMDB HMDB0001096
xref: Reference/CAS 590-55-6
xref: Reference/KEGG Compound C00169
xref: Reference/ChEBI CHEBI 17672
chemical formula: CH4NO5P
molecular weight: 140.98271
structure: ChemicalStructure/PW C000862

L-Glutamic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Glutamic acid

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Glutamate dehydrogenase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Glutamate dehydrogenase, mitochondrial

Reference/CAS 7664-38-2
type: UnificationXref
id: 7664-38-2
db: CAS

Compound/PW C000134 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxoglutaric acid
stoichiometric coefficient: 1.0

Urocanic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Urocanic acid

Protein/10981 Mitochondrial Matrix/Stoichiometry/10.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 10.0

Compound/PW C000035 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonia
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/UniProt Q9VKR4
type: UnificationXref
id: Q9VKR4
db: UniProt

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

NADH
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: NADH

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/CAS 135-16-0
type: UnificationXref
id: 135-16-0
db: CAS

Reference/ChemSpider 1031
type: UnificationXref
id: 1031
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/ChemSpider 388320
type: UnificationXref
id: 388320
db: ChemSpider

Carbamoyl phosphate
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Carbamoyl phosphate
name: SubPathwayInput

Pyruvic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyruvic acid
name: SubPathwayInput

Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Compound/PW C001316 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H28N7O14P2
molecular weight: 664.11694
structure: ChemicalStructure/PW C000721

Reference/PubChem-compound 44367445
type: UnificationXref
id: 44367445
db: PubChem-compound

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine triphosphate

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

L-Asparagine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Asparagine

Compound/PW C000414 Mitochondrial Matrix/Stoichiometry/2.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 2.0

Reference/KEGG Compound C00014
type: UnificationXref
id: C00014
db: KEGG Compound

Reference/KEGG Compound C00135
type: UnificationXref
id: C00135
db: KEGG Compound

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Compound/PW C000078 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glycine
stoichiometric coefficient: 1.0

Pyruvic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pyruvic acid

Reference/PubChem-compound 6112
type: UnificationXref
id: 6112
db: PubChem-compound

Phosphate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Phosphate

Reference/KEGG Compound C00022
type: UnificationXref
id: C00022
db: KEGG Compound

Reference/KEGG Compound C00143
type: UnificationXref
id: C00143
db: KEGG Compound

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Protein/15265 Mitochondrial Matrix/Stoichiometry/2.0
type: Stoichiometry
physical entity: Glycine cleavage system P protein
stoichiometric coefficient: 2.0

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/KEGG Compound C00026
type: UnificationXref
id: C00026
db: KEGG Compound

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

Reference/ChEBI CHEBI 26078
type: UnificationXref
id: CHEBI:26078
db: ChEBI

ChemicalStructure/PW C008526
type: ChemicalStructure
structure format: SMILES
structure data: NCSCCC(S)CCCCC(O)=O

Reference/CAS 3432-99-3
type: UnificationXref
id: 3432-99-3
db: CAS

Reference/CAS 104-98-3
type: UnificationXref
id: 104-98-3
db: CAS

L-Glutamic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: L-Glutamic acid

Reference/KEGG Compound C00152
type: UnificationXref
id: C00152
db: KEGG Compound

Compound/PW C000164 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 1.0

Asparagine synthetase
type: Protein
cellular location: Cytoplasm
entity reference: Asparagine synthetase

Reference/KEGG Compound C00037
type: UnificationXref
id: C00037
db: KEGG Compound

Reference/CAS 328-50-7
type: UnificationXref
id: 328-50-7
db: CAS

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

L-Histidine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Histidine
name: SubPathwayOutput

Reference/UniProt Q7KTW9
type: UnificationXref
id: Q7KTW9
db: UniProt

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])(=O)OP([O-])([O-])=O

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Compound/PW C001104 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/BioCyc LIPOIC-ACID
type: UnificationXref
id: LIPOIC-ACID
db: BioCyc

Reference/ChEBI CHEBI 17196
type: UnificationXref
id: CHEBI:17196
db: ChEBI

GH22838p
type: ProteinReference
xref: Reference/UniProt Q961I1
organism: Drosophila melanogaster

Reference/ChemSpider 408
type: UnificationXref
id: 408
db: ChemSpider

L-Glutamine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Glutamine

Reference/KEGG Compound C00049
type: UnificationXref
id: C00049
db: KEGG Compound

Reference/ChEBI CHEBI 18047
type: UnificationXref
id: CHEBI:18047
db: ChEBI

Reference/KEGG Compound C00169
type: UnificationXref
id: C00169
db: KEGG Compound

Reference/CAS 56-85-9
type: UnificationXref
id: 56-85-9
db: CAS

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

(R)-lipoic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: (R)-lipoic acid

Probable isoaspartyl peptidase/L-asparaginase CG7860
type: Protein
cellular location: Cytoplasm
entity reference: Probable isoaspartyl peptidase/L-asparaginase CG7860

Reference/PubChem-compound 421
type: UnificationXref
id: 421
db: PubChem-compound

Unknown
type: ProteinReference
organism: Drosophila melanogaster

Reference/UniProt Q9VXD5
type: UnificationXref
id: Q9VXD5
db: UniProt

Ammonia
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Ammonia

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

Reference/UniProt Q9VHE9
type: UnificationXref
id: Q9VHE9
db: UniProt

ChemicalStructure/PW C001120
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCCC[C@@H]1CCSS1

Compound/PW C000095 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Reference/BioCyc AMMONIA
type: UnificationXref
id: AMMONIA
db: BioCyc

ChemicalStructure/PW C000035
type: ChemicalStructure
structure format: SMILES
structure data: N

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

Reference/CAS 590-55-6
type: UnificationXref
id: 590-55-6
db: CAS

Compound/PW C001120 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: (R)-lipoic acid
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/ChEBI CHEBI 17053
type: UnificationXref
id: CHEBI:17053
db: ChEBI

Reference/CAS 56-40-6
type: UnificationXref
id: 56-40-6
db: CAS

Reference/KEGG Compound C00065
type: UnificationXref
id: C00065
db: KEGG Compound

Reference/KEGG Compound C00064
type: UnificationXref
id: C00064
db: KEGG Compound

NAD
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: NAD

Pyrophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pyrophosphate

ChemicalStructure/PW C000164
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)C(O)=O

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

Reference/HMDB HMDB0000168
type: UnificationXref
id: HMDB0000168
db: HMDB

Ammonia
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Ammonia

Reference/BioCyc UROCANATE
type: UnificationXref
id: UROCANATE
db: BioCyc

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

CG8129, isoform B
type: ProteinReference
xref: Reference/UniProt Q9VHE9
organism: Drosophila melanogaster

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Reference/ChemSpider 979
type: UnificationXref
id: 979
db: ChemSpider

Reference/HMDB HMDB0000177
type: UnificationXref
id: HMDB0000177
db: HMDB

Reference/ChemSpider 730
type: UnificationXref
id: 730
db: ChemSpider

Water
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Water

Phosphoric acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/ChEBI CHEBI 26078
xref: Reference/CAS 7664-38-2
xref: Reference/PubChem-compound 1004
xref: Reference/ChemSpider 979
xref: Reference/HMDB HMDB0002142
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001441

Glutamate Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108772
pathway component: SubPathwayInteraction108772
xref: Reference/SMPDB SMP0000072
xref: Reference/PathWhiz PW000003
name: SubPathway

Reference/HMDB HMDB0000051
type: UnificationXref
id: HMDB0000051
db: HMDB

L-Asparagine
type: SmallMoleculeReference
xref: Reference/ChemSpider 6031
xref: Reference/HMDB HMDB0000168
xref: Reference/CAS 70-47-3
xref: Reference/ChEBI CHEBI 17196
xref: Reference/BioCyc ASN
xref: Reference/KEGG Compound C00152
xref: Reference/PubChem-compound 6267
chemical formula: C4H8N2O3
molecular weight: 132.0535
structure: ChemicalStructure/PW C000110

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Adenosine diphosphate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Adenosine diphosphate

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/BioCyc PYRUVATE
type: UnificationXref
id: PYRUVATE
db: BioCyc

L-Histidine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15971
xref: Reference/HMDB HMDB0000177
xref: Reference/PubChem-compound 6274
xref: Reference/ChemSpider 6038
xref: Reference/CAS 71-00-1
xref: Reference/BioCyc HIS
xref: Reference/KEGG Compound C00135
chemical formula: C6H9N3O2
molecular weight: 155.06947
structure: ChemicalStructure/PW C000116

Glycine cleavage system P protein
type: ProteinReference
xref: Reference/UniProt Q9VH09
organism: Drosophila melanogaster

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

Aminomethyltransferase
type: ProteinReference
xref: Reference/UniProt Q9VKR4
organism: Drosophila melanogaster

Reference/KEGG Compound C02147
type: UnificationXref
id: C02147
db: KEGG Compound

Protein/15101 Mitochondrial Matrix/Stoichiometry/6.0
type: Stoichiometry
physical entity: Glutamate dehydrogenase, mitochondrial
stoichiometric coefficient: 6.0

L-Aspartic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 44367445
xref: Reference/ChemSpider 5745
xref: Reference/ChEBI CHEBI 17053
xref: Reference/HMDB HMDB0000191
xref: Reference/CAS 56-84-8
xref: Reference/KEGG Compound C00049
xref: Reference/BioCyc L-ASPARTATE
chemical formula: C4H7NO4
molecular weight: 133.0375
structure: ChemicalStructure/PW C000123

L-Serine
type: SmallMoleculeReference
xref: Reference/ChemSpider 5736
xref: Reference/ChEBI CHEBI 17115
xref: Reference/CAS 56-45-1
xref: Reference/KEGG Compound C00065
xref: Reference/PubChem-compound 5951
xref: Reference/HMDB HMDB0000187
xref: Reference/BioCyc SER
chemical formula: C3H7NO3
molecular weight: 105.042595
structure: ChemicalStructure/PW C000120

Reaction148260
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000035 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000120 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Cytoplasm/Stoichiometry/1.0
right: Pyruvic acid
right: Ammonia
spontaneous: false
left: L-Serine
name: L-Serine → Ammonia + Pyruvic acid
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0000187
type: UnificationXref
id: HMDB0000187
db: HMDB

Reaction148261
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000035 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000123 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000110 Cytoplasm/Stoichiometry/1.0
right: L-Aspartic acid
right: Ammonia
spontaneous: false
left: Water
left: L-Asparagine
name: L-Asparagine + Water ↔ Ammonia + L-Aspartic acid
conversion direction: REVERSIBLE

4.3.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000035 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000116 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000205 Cytoplasm/Stoichiometry/1.0
right: Ammonia
right: Urocanic acid
spontaneous: false
EC number: 4.3.1.3
left: L-Histidine
name: L-Histidine ↔ Ammonia + Urocanic acid
conversion direction: REVERSIBLE

2.1.2.10
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001178 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C008526 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007757 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001221 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Mitochondrial Matrix/Stoichiometry/1.0
right: 5,10-Methylene-THF
right: Ammonia
right: Dihydrolipoate
spontaneous: false
EC number: 2.1.2.10
left: 8-[(Aminomethyl)sulfanyl]-6-sulfanyloctanoic acid
left: Tetrahydrofolic acid
name: 8-[(Aminomethyl)sulfanyl]-6-sulfanyloctanoic acid + Tetrahydrofolic acid → 5,10-Methylene-THF + Ammonia + Dihydrolipoate
conversion direction: LEFT_TO_RIGHT

1.8.1.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001120 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007757 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
right: (R)-lipoic acid
right: NADH
spontaneous: false
EC number: 1.8.1.4
left: Dihydrolipoate
left: NAD
name: Dihydrolipoate + NAD → (R)-lipoic acid + NADH
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

1.4.4.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001120 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C008526 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000078 Mitochondrial Matrix/Stoichiometry/1.0
right: Carbon dioxide
right: 8-[(Aminomethyl)sulfanyl]-6-sulfanyloctanoic acid
spontaneous: false
EC number: 1.4.4.2
left: Glycine
left: (R)-lipoic acid
name: (R)-lipoic acid + Glycine → 8-[(Aminomethyl)sulfanyl]-6-sulfanyloctanoic acid + Carbon dioxide
conversion direction: LEFT_TO_RIGHT

Urocanic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000301
xref: Reference/ChemSpider 643824
xref: Reference/CAS 104-98-3
xref: Reference/ChEBI CHEBI 30817
xref: Reference/KEGG Compound C00785
xref: Reference/BioCyc UROCANATE
xref: Reference/PubChem-compound 736715
chemical formula: C6H6N2O2
molecular weight: 138.04292
structure: ChemicalStructure/PW C000205

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

Unknown
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Unknown

L-Aspartic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Aspartic acid
name: SubPathwayInput

Reference/ChEBI CHEBI 18050
type: UnificationXref
id: CHEBI:18050
db: ChEBI

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/BioCyc 6-S-ACETYL-DIHYDROLIPOATE
type: UnificationXref
id: 6-S-ACETYL-DIHYDROLIPOATE
db: BioCyc

ChemicalStructure/PW C000078
type: ChemicalStructure
structure format: SMILES
structure data: NCC(O)=O

Reference/HMDB HMDB0000191
type: UnificationXref
id: HMDB0000191
db: HMDB

Phosphoric acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Phosphoric acid

Glycine
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Glycine
name: SubPathwayOutput

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

6.3.5.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000123 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000110 Cytoplasm/Stoichiometry/1.0
right: Adenosine monophosphate
right: L-Glutamic acid
right: L-Asparagine
right: Pyrophosphate
spontaneous: false
EC number: 6.3.5.4
left: L-Aspartic acid
left: Water
left: Adenosine triphosphate
left: L-Glutamine
name: Adenosine triphosphate + L-Aspartic acid + L-Glutamine + Water ↔ Adenosine monophosphate + L-Asparagine + L-Glutamic acid + Pyrophosphate
conversion direction: REVERSIBLE

Compound/PW C001221 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tetrahydrofolic acid
stoichiometric coefficient: 1.0

Reference/CAS 56-84-8
type: UnificationXref
id: 56-84-8
db: CAS

Reference/CAS 70-47-3
type: UnificationXref
id: 70-47-3
db: CAS

ChemicalStructure/PW C001178
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0002142
type: UnificationXref
id: HMDB0002142
db: HMDB

ReactionCatalysis138426
type: Catalysis
controller: Asparagine synthetase
controlled: 6.3.5.4
control type: ACTIVATION

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

Aminomethyltransferase
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Aminomethyltransferase

ChemicalStructure/PW C000205
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)\C=C\C1=CNC=N1

Adenosine triphosphate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Adenosine triphosphate

(R)-lipoic acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C16241
xref: Reference/ChEBI CHEBI 30314
xref: Reference/CAS 62-46-4
xref: Reference/PubChem-compound 6112
xref: Reference/ChemSpider 5886
xref: Reference/BioCyc LIPOIC-ACID
xref: Reference/HMDB HMDB0001451
chemical formula: C8H14O2S2
molecular weight: 206.04352
structure: ChemicalStructure/PW C001120

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Ammonia
type: SmallMoleculeReference
xref: Reference/BioCyc AMMONIA
xref: Reference/CAS 7664-41-7
xref: Reference/HMDB HMDB0000051
xref: Reference/PubChem-compound 222
xref: Reference/KEGG Compound C00014
xref: Reference/ChEBI CHEBI 16134
xref: Reference/ChemSpider 217
chemical formula: H3N
molecular weight: 17.026548
structure: ChemicalStructure/PW C000035

Unknown
type: Protein
cellular location: Cytoplasm
entity reference: Unknown

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

Reference/ChEBI CHEBI 15971
type: UnificationXref
id: CHEBI:15971
db: ChEBI

6.3.1.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001034 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Mitochondrial Matrix/Stoichiometry/1.0
right: L-Glutamine
right: Phosphate
right: Adenosine diphosphate
spontaneous: false
EC number: 6.3.1.2
left: Ammonia
left: Adenosine triphosphate
left: L-Glutamic acid
name: Adenosine triphosphate + Ammonia + L-Glutamic acid → Adenosine diphosphate + L-Glutamine + Phosphate
conversion direction: LEFT_TO_RIGHT

3.5.1.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Mitochondrial Matrix/Stoichiometry/1.0
right: Ammonia
right: L-Glutamic acid
spontaneous: false
EC number: 3.5.1.2
left: L-Glutamine
left: Water
name: L-Glutamine + Water → Ammonia + L-Glutamic acid
conversion direction: LEFT_TO_RIGHT

Glutamate dehydrogenase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q9VCF7
organism: Drosophila melanogaster

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/PubChem-compound 1004
type: UnificationXref
id: 1004
db: PubChem-compound

Reference/PubChem-compound 5961
type: UnificationXref
id: 5961
db: PubChem-compound

Compound/PW C000123 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Aspartic acid
stoichiometric coefficient: 1.0

Reference/CAS 62-46-4
type: UnificationXref
id: 62-46-4
db: CAS

Histidine Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108768
pathway component: SubPathwayInteraction108768
xref: Reference/PathWhiz PW000043
xref: Reference/SMPDB SMP0000044
name: SubPathway

Reference/HMDB HMDB0000301
type: UnificationXref
id: HMDB0000301
db: HMDB

Water
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Water

Reference/PubChem-compound 51
type: UnificationXref
id: 51
db: PubChem-compound

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Pyruvic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 1060
xref: Reference/HMDB HMDB0000243
xref: Reference/CAS 127-17-3
xref: Reference/BioCyc PYRUVATE
xref: Reference/KEGG Compound C00022
xref: Reference/ChEBI CHEBI 32816
xref: Reference/ChemSpider 1031
chemical formula: C3H4O3
molecular weight: 88.016045
structure: ChemicalStructure/PW C000164

6.3.4.16
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Mitochondrial Matrix/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001316 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Mitochondrial Matrix/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000862 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001441 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Mitochondrial Matrix/Stoichiometry/1.0
right: Phosphoric acid
right: Carbamoyl phosphate
right: Adenosine diphosphate
spontaneous: false
EC number: 6.3.4.16
left: Water
left: Carbon dioxide
left: Ammonia
left: Adenosine triphosphate
name: 2 Adenosine triphosphate + Ammonia + Carbon dioxide + Water → 2 Adenosine diphosphate + Carbamoyl phosphate + Phosphoric acid
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C16241
type: UnificationXref
id: C16241
db: KEGG Compound

1.4.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Mitochondrial Matrix/Stoichiometry/1.0
right: Ammonia
right: Oxoglutaric acid
right: NADH
spontaneous: false
EC number: 1.4.1.3
left: Water
left: L-Glutamic acid
left: NAD
name: L-Glutamic acid + NAD + Water → Ammonia + NADH + Oxoglutaric acid
conversion direction: LEFT_TO_RIGHT

Compound/PW C000095 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 6038
type: UnificationXref
id: 6038
db: ChemSpider

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Tetrahydrofolic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 20506
xref: Reference/ChemSpider 18714427
xref: Reference/HMDB HMDB0001846
xref: Reference/PubChem-compound 13781857
xref: Reference/BioCyc THF
xref: Reference/CAS 135-16-0
xref: Reference/KEGG Compound C00101
chemical formula: C19H23N7O6
molecular weight: 445.171
structure: ChemicalStructure/PW C001221

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Reference/ChemSpider 272
type: UnificationXref
id: 272
db: ChemSpider

Oxoglutaric acid
type: SmallMoleculeReference
xref: Reference/CAS 328-50-7
xref: Reference/PubChem-compound 51
xref: Reference/BioCyc 2-KETOGLUTARATE
xref: Reference/HMDB HMDB0000208
xref: Reference/ChEBI CHEBI 30915
xref: Reference/KEGG Compound C00026
xref: Reference/ChemSpider 50
chemical formula: C5H6O5
molecular weight: 146.02153
structure: ChemicalStructure/PW C000134

Urea Cycle
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108770
pathway component: SubPathwayInteraction108770
xref: Reference/SMPDB SMP0000059
xref: Reference/PathWhiz PW000162
name: SubPathway

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Citric Acid Cycle
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108769
pathway component: SubPathwayInteraction108769
xref: Reference/PathWhiz PW000005
xref: Reference/SMPDB SMP0000057
name: SubPathway

Probable isoaspartyl peptidase/L-asparaginase CG7860
type: ProteinReference
xref: Reference/UniProt Q9VXT7
organism: Drosophila melanogaster

CAD protein
type: ProteinReference
xref: Reference/UniProt Q9VXD5
organism: Drosophila melanogaster

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: O4P
molecular weight: 94.95342
structure: ChemicalStructure/PW C001104

Reference/BioCyc SER
type: UnificationXref
id: SER
db: BioCyc

Glycine cleavage system P protein
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Glycine cleavage system P protein

Aspartate Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108773
pathway component: SubPathwayInteraction108773
xref: Reference/PathWhiz PW000002
xref: Reference/SMPDB SMP0000067
name: SubPathway

Reference/ChemSpider 6031
type: UnificationXref
id: 6031
db: ChemSpider

Reference/HMDB HMDB0001533
type: UnificationXref
id: HMDB0001533
db: HMDB

Mitochondrion
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005739

Reference/BioCyc THF
type: UnificationXref
id: THF
db: BioCyc

Reference/BioCyc GLY
type: UnificationXref
id: GLY
db: BioCyc

CAD protein
type: Protein
cellular location: Mitochondrial Matrix
entity reference: CAD protein

Reference/HMDB HMDB0000208
type: UnificationXref
id: HMDB0000208
db: HMDB

Reference/CAS 71-00-1
type: UnificationXref
id: 71-00-1
db: CAS

Reference/ChemSpider 217
type: UnificationXref
id: 217
db: ChemSpider

Compound/PW C000110 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Asparagine
stoichiometric coefficient: 1.0

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

ChemicalStructure/PW C001221
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])([O-])=O

ChemicalStructure/PW C000134
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(=O)C(O)=O

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Reference/ChEBI CHEBI 30915
type: UnificationXref
id: CHEBI:30915
db: ChEBI

Reference/HMDB HMDB0013639
type: UnificationXref
id: HMDB0013639
db: HMDB

Glycine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000123
xref: Reference/BioCyc GLY
xref: Reference/ChemSpider 730
xref: Reference/PubChem-compound 5257127
xref: Reference/CAS 56-40-6
xref: Reference/ChEBI CHEBI 15428
xref: Reference/KEGG Compound C00037
chemical formula: C2H5NO2
molecular weight: 75.03203
structure: ChemicalStructure/PW C000078

Reference/SMPDB SMP0000044
type: UnificationXref
id: SMP0000044
db: SMPDB

L-Glutamine
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: L-Glutamine

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/PubChem-compound 5257127
type: UnificationXref
id: 5257127
db: PubChem-compound

Reference/GENE ONTOLOGY GO 0005759
type: UnificationXref
id: GO:0005759
db: GENE ONTOLOGY

5,10-Methylene-THF
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001533
xref: Reference/CAS 3432-99-3
xref: Reference/PubChem-compound 439175
xref: Reference/ChEBI CHEBI 15636
xref: Reference/KEGG Compound C00143
xref: Reference/BioCyc METHYLENE-THF
xref: Reference/ChemSpider 388320
chemical formula: C20H23N7O6
molecular weight: 457.171
structure: ChemicalStructure/PW C001178

Reference/BioCyc GLN
type: UnificationXref
id: GLN
db: BioCyc

Reference/CAS 7664-41-7
type: UnificationXref
id: 7664-41-7
db: CAS

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

Reference/SMPDB SMP0000059
type: UnificationXref
id: SMP0000059
db: SMPDB

Reference/SMPDB SMP0000057
type: UnificationXref
id: SMP0000057
db: SMPDB

Glycine and Serine Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108771
pathway order: SubPathwayInteractionSteps/SubPathway108767
pathway component: SubPathwayInteraction108767
pathway component: SubPathwayInteraction108771
xref: Reference/PathWhiz PW000157
xref: Reference/SMPDB SMP0000004
name: SubPathway

Reference/CAS 462-20-4
type: UnificationXref
id: 462-20-4
db: CAS

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Reference/PubChem-compound 5951
type: UnificationXref
id: 5951
db: PubChem-compound

Reference/PubChem-compound 222
type: UnificationXref
id: 222
db: PubChem-compound

Reference/HMDB HMDB0012210
type: UnificationXref
id: HMDB0012210
db: HMDB

ChemicalStructure/PW C000110
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC(N)=O)C(O)=O

Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001441
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: O7P2
molecular weight: 173.91193
structure: ChemicalStructure/PW C000170

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/SMPDB SMP0000067
type: UnificationXref
id: SMP0000067
db: SMPDB

CG8129, isoform B
type: Protein
cellular location: Cytoplasm
entity reference: CG8129, isoform B

Reference/ChEBI CHEBI 15636
type: UnificationXref
id: CHEBI:15636
db: ChEBI

ChemicalStructure/PW C000116
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CN=CN1)C(O)=O

Reference/HMDB HMDB0000123
type: UnificationXref
id: HMDB0000123
db: HMDB

Reference/SMPDB SMP0000072
type: UnificationXref
id: SMP0000072
db: SMPDB

ChemicalStructure/PW C000120
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CO)C(O)=O

Reference/HMDB HMDB0000243
type: UnificationXref
id: HMDB0000243
db: HMDB

Reference/GENE ONTOLOGY GO 0005739
type: UnificationXref
id: GO:0005739
db: GENE ONTOLOGY

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

ChemicalStructure/PW C000123
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC(O)=O)C(O)=O

Compound/PW C000205 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Urocanic acid
stoichiometric coefficient: 1.0

Glutamate dehydrogenase 1, mitochondrial
type: Complex
component stoichiometry: Protein/15101 Mitochondrial Matrix/Stoichiometry/6.0
cellular location: Mitochondrial Matrix
component: Glutamate dehydrogenase, mitochondrial

Reference/HMDB HMDB0001451
type: UnificationXref
id: HMDB0001451
db: HMDB

Reference/TAXONOMY 7227
type: UnificationXref
id: 7227
db: TAXONOMY

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Compound/PW C000414 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

5,10-Methylene-THF
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: 5,10-Methylene-THF

L-serine dehydratase/L-threonine deaminase
type: Complex
component stoichiometry: Protein/15256 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: CG8129, isoform B

Reference/SMPDB SMP0000004
type: UnificationXref
id: SMP0000004
db: SMPDB

Mitochondrial Matrix
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005759

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/BioCyc CARBAMOYL-P
type: UnificationXref
id: CARBAMOYL-P
db: BioCyc

ChemicalStructure/PW C000862
type: ChemicalStructure
structure format: SMILES
structure data: NC(=O)OP(O)(O)=O

Dihydrolipoate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 421
xref: Reference/CAS 462-20-4
xref: Reference/BioCyc 6-S-ACETYL-DIHYDROLIPOATE
xref: Reference/KEGG Compound C02147
xref: Reference/ChemSpider 408
xref: Reference/ChEBI CHEBI 18047
xref: Reference/HMDB HMDB0012210
chemical formula: C8H16O2S2
molecular weight: 208.05917
structure: ChemicalStructure/PW C007757

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Glycine
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Glycine

Reference/SMPDB SMP0087375
type: UnificationXref
id: SMP0087375
db: SMPDB

Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Reference/CAS 127-17-3
type: UnificationXref
id: 127-17-3
db: CAS

Reference/ChEBI CHEBI 30817
type: UnificationXref
id: CHEBI:30817
db: ChEBI

Compound/PW C000500 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamine
stoichiometric coefficient: 1.0

Reference/BioCyc HIS
type: UnificationXref
id: HIS
db: BioCyc

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

Compound/PW C007757 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydrolipoate
stoichiometric coefficient: 1.0

Reference/UniProt Q961I1
type: UnificationXref
id: Q961I1
db: UniProt

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Glutamine synthetase
type: Complex
component stoichiometry: Protein/10981 Mitochondrial Matrix/Stoichiometry/10.0
cellular location: Mitochondrial Matrix
component: Unknown

Reference/ChEBI CHEBI 15428
type: UnificationXref
id: CHEBI:15428
db: ChEBI

ReactionCatalysis138466
type: Catalysis
controller: Glutamate dehydrogenase 1, mitochondrial
controlled: 1.4.1.3
control type: ACTIVATION

Reference/BioCyc 2-KETOGLUTARATE
type: UnificationXref
id: 2-KETOGLUTARATE
db: BioCyc

Oxoglutaric acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Oxoglutaric acid

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Compound/PW C001178 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5,10-Methylene-THF
stoichiometric coefficient: 1.0

Compound/PW C008526 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: 8-[(Aminomethyl)sulfanyl]-6-sulfanyloctanoic acid
stoichiometric coefficient: 1.0

ReactionCatalysis138581
type: Catalysis
controller: Dihydrolipoyl dehydrogenase
controlled: 1.8.1.4
control type: ACTIVATION

ReactionCatalysis138580
type: Catalysis
controller: Aminomethyltransferase
controlled: 2.1.2.10
control type: ACTIVATION

ReactionCatalysis138461
type: Catalysis
controller: CAD protein
controlled: 6.3.4.16
control type: ACTIVATION

ReactionCatalysis138582
type: Catalysis
controller: Glycine dehydrogenase [decarboxylating], mitochondrial
controlled: 1.4.4.2
control type: ACTIVATION

Reference/ChEBI CHEBI 32816
type: UnificationXref
id: CHEBI:32816
db: ChEBI

L-Serine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Serine
name: SubPathwayOutput

Asparagine synthetase
type: ProteinReference
xref: Reference/UniProt Q7KTW9
organism: Drosophila melanogaster

Compound/PW C000032 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

GH22838p
type: Protein
cellular location: Mitochondrial Matrix
entity reference: GH22838p

Reference/PubChem-compound 278
type: UnificationXref
id: 278
db: PubChem-compound

Reference/CAS 56-45-1
type: UnificationXref
id: 56-45-1
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17672
type: UnificationXref
id: CHEBI:17672
db: ChEBI

Reference/UniProt Q9VXT7
type: UnificationXref
id: Q9VXT7
db: UniProt

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

8-[(Aminomethyl)sulfanyl]-6-sulfanyloctanoic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 53481912
xref: Reference/HMDB HMDB0013639
chemical formula: C9H19NO2S2
molecular weight: 237.08572
structure: ChemicalStructure/PW C008526

L-Serine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Serine

Dihydrolipoyl dehydrogenase
type: ProteinReference
xref: Reference/UniProt Q9VVL7
organism: Drosophila melanogaster

Carbamoyl phosphate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Carbamoyl phosphate

Reference/PubChem-compound 736715
type: UnificationXref
id: 736715
db: PubChem-compound

Reference/PathWhiz PW000002
type: UnificationXref
id: PW000002
db: PathWhiz

Reference/PathWhiz PW000005
type: UnificationXref
id: PW000005
db: PathWhiz

Reference/PathWhiz PW000003
type: UnificationXref
id: PW000003
db: PathWhiz

ChemicalStructure/PW C000500
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(N)=O)C(O)=O

Reference/UniProt Q9VVL7
type: UnificationXref
id: Q9VVL7
db: UniProt

Reference/UniProt Q9VH09
type: UnificationXref
id: Q9VH09
db: UniProt

Reference/PubChem-compound 1060
type: UnificationXref
id: 1060
db: PubChem-compound

ReactionCatalysis138578
type: Catalysis
controller: Probable isoaspartyl peptidase/L-asparaginase CG7860
controlled: Reaction148261
control type: ACTIVATION

ReactionCatalysis138577
type: Catalysis
controller: L-serine dehydratase/L-threonine deaminase
controlled: Reaction148260
control type: ACTIVATION

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

ReactionCatalysis138456
type: Catalysis
controller: GH22838p
controlled: 3.5.1.2
control type: ACTIVATION

ReactionCatalysis138579
type: Catalysis
controller: Unknown
controlled: 4.3.1.3
control type: ACTIVATION

ReactionCatalysis138455
type: Catalysis
controller: Glutamine synthetase
controlled: 6.3.1.2
control type: ACTIVATION

Reference/PathWhiz PW088394
type: UnificationXref
id: PW088394
db: PathWhiz

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/HMDB HMDB0001846
type: UnificationXref
id: HMDB0001846
db: HMDB

Reference/KEGG Compound C00785
type: UnificationXref
id: C00785
db: KEGG Compound

8-[(Aminomethyl)sulfanyl]-6-sulfanyloctanoic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: 8-[(Aminomethyl)sulfanyl]-6-sulfanyloctanoic acid

Reference/HMDB HMDB0000641
type: UnificationXref
id: HMDB0000641
db: HMDB

Compound/PW C000116 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Histidine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 13781857
type: UnificationXref
id: 13781857
db: PubChem-compound

Dihydrolipoate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Dihydrolipoate