Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Compound/PW C001977 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoroselenoic acid
stoichiometric coefficient: 1.0

Reference/KEGG Compound C01528
type: UnificationXref
id: C01528
db: KEGG Compound

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/ChEBI CHEBI 16134
type: UnificationXref
id: CHEBI:16134
db: ChEBI

Compound/PW C000035 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonia
stoichiometric coefficient: 1.0

Reference/ChemSpider 57
type: UnificationXref
id: 57
db: ChemSpider

Putative cystathionine gamma-lyase 2
type: ProteinReference
xref: Reference/UniProt P55216
organism: Caenorhabditis elegans

Protein/14811 Cytoplasm/Stoichiometry/4.0
type: Stoichiometry
physical entity: Cysteine synthase 1
stoichiometric coefficient: 4.0

Probable selenide, water dikinase
type: ProteinReference
xref: Reference/UniProt O62461
organism: Caenorhabditis elegans

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

Reference/ChEBI CHEBI 17115
type: UnificationXref
id: CHEBI:17115
db: ChEBI

3'-Phosphoadenosine 5'-Phosphosulfate Synthetase
type: Protein
cellular location: Cytoplasm
entity reference: 3'-Phosphoadenosine 5'-Phosphosulfate Synthetase

Selenohomocysteine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Selenohomocysteine

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Unknown
type: Protein
cellular location: Cytoplasm
entity reference: Unknown

Protein/14807 Cytoplasm/Stoichiometry/4.0
type: Stoichiometry
physical entity: Putative cystathionine gamma-lyase 2
stoichiometric coefficient: 4.0

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Adenosylhomocysteinase
type: ProteinReference
xref: Reference/UniProt P27604
organism: Caenorhabditis elegans

Cysteine synthase 1
type: ProteinReference
xref: Reference/UniProt Q93244
organism: Caenorhabditis elegans

Reference/ChemSpider 17615371
type: UnificationXref
id: 17615371
db: ChemSpider

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Probable S-adenosylmethionine synthase 3
type: Protein
cellular location: Cytoplasm
entity reference: Probable S-adenosylmethionine synthase 3

Reference/ChEBI CHEBI 9100
type: UnificationXref
id: CHEBI:9100
db: ChEBI

Reference/KEGG Compound C00212
type: UnificationXref
id: C00212
db: KEGG Compound

Compound/PW C002066 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Selenohomocysteine
stoichiometric coefficient: 1.0

Compound/PW C006724 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: γ-Glutamyl-Se-methylselenocysteine
stoichiometric coefficient: 1.0

RNA/9 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: tRNA(Met)
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0004119
type: UnificationXref
id: HMDB0004119
db: HMDB

Probable S-adenosylmethionine synthase 3
type: ProteinReference
xref: Reference/UniProt P50305
organism: Caenorhabditis elegans

Reference/HMDB HMDB0004113
type: UnificationXref
id: HMDB0004113
db: HMDB

Reference/HMDB HMDB0004112
type: UnificationXref
id: HMDB0004112
db: HMDB

Methyltransferase-like protein
type: ProteinReference
xref: Reference/UniProt Q23383
organism: Caenorhabditis elegans

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

Reference/ChemSpider 5736
type: UnificationXref
id: 5736
db: ChemSpider

Adenosine monophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine monophosphate

Methionine--tRNA ligase, cytoplasmic
type: ProteinReference
xref: Reference/UniProt Q20970
organism: Caenorhabditis elegans

Reference/ChemSpider 5735
type: UnificationXref
id: 5735
db: ChemSpider

Reference/KEGG Compound C00109
type: UnificationXref
id: C00109
db: KEGG Compound

Intestinal Digestion and Absorption
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108901
pathway component: SubPathwayInteraction108901
name: SubPathway

ChemicalStructure/PW C002066
type: ChemicalStructure
structure format: SMILES
structure data: NC(CC[SeH])C(O)=O

Reference/PubChem-compound 24892762
type: UnificationXref
id: 24892762
db: PubChem-compound

ChemicalStructure/PW C002067
type: ChemicalStructure
structure format: SMILES
structure data: NC(C[Se][Se]CC(N)C(O)=O)C(O)=O

Reference/PubChem-compound 24892761
type: UnificationXref
id: 24892761
db: PubChem-compound

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Reference/CAS 10236-58-5
type: UnificationXref
id: 10236-58-5
db: CAS

Se-Adenosylselenomethionine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Se-Adenosylselenomethionine

ChemicalStructure/PW C002063
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 28450
type: UnificationXref
id: CHEBI:28450
db: ChEBI

ChemicalStructure/PW C002064
type: ChemicalStructure
structure format: SMILES
structure data: C[Se]C[C@H](N)C(O)=O

3'-Phosphoadenosine 5'-Phosphosulfate Synthetase
type: ProteinReference
xref: Reference/UniProt Q22501
organism: Caenorhabditis elegans

Reference/HMDB HMDB0004122
type: UnificationXref
id: HMDB0004122
db: HMDB

Compound/PW C000120 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Serine
stoichiometric coefficient: 1.0

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/CAS 7664-38-2
type: UnificationXref
id: 7664-38-2
db: CAS

Reference/HMDB HMDB0003288
type: UnificationXref
id: HMDB0003288
db: HMDB

Adenosine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

CH3-R
type: SmallMolecule
cellular location: Cytoplasm
entity reference: CH3-R

Reference/UniProt V6CLP9
type: UnificationXref
id: V6CLP9
db: UniProt

Reference/BioCyc L-ALPHA-ALANINE
type: UnificationXref
id: L-ALPHA-ALANINE
db: BioCyc

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/CAS 56-41-7
type: UnificationXref
id: 56-41-7
db: CAS

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/BioCyc 2-OXOBUTANOATE
type: UnificationXref
id: 2-OXOBUTANOATE
db: BioCyc

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Phosphoroselenoic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphoroselenoic acid

Reference/UniProt O62461
type: UnificationXref
id: O62461
db: UniProt

ReactionCatalysis139139
type: Catalysis
controller: Probable selenide, water dikinase
controlled: 2.7.9.3
control type: ACTIVATION

ReactionCatalysis139138
type: Catalysis
controller: Selenocysteine lyase
controlled: 4.4.1.16
control type: ACTIVATION

Reference/ChemSpider 389628
type: UnificationXref
id: 389628
db: ChemSpider

Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C05704
type: UnificationXref
id: C05704
db: KEGG Compound

ChemicalStructure/PW C040445
type: ChemicalStructure
structure format: SMILES
structure data: O[Se](O)(=O)=O

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine triphosphate

Reference/ChemSpider 1061
type: UnificationXref
id: 1061
db: ChemSpider

Reference/ChEBI CHEBI 18212
type: UnificationXref
id: CHEBI:18212
db: ChEBI

Reference/KEGG Compound C00014
type: UnificationXref
id: C00014
db: KEGG Compound

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Reference/ChemSpider 389629
type: UnificationXref
id: 389629
db: ChemSpider

Reference/ChemSpider 1059
type: UnificationXref
id: 1059
db: ChemSpider

Selenocysteine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 16633
xref: Reference/PubChem-compound 25076
xref: Reference/CAS 10236-58-5
xref: Reference/HMDB HMDB0003288
xref: Reference/BioCyc L-SELENOCYSTEINE
xref: Reference/KEGG Compound C05688
xref: Reference/ChemSpider 23436
chemical formula: C3H7NO2Se
molecular weight: 168.9642
structure: ChemicalStructure/PW C001829

Reference/ChemSpider 1058
type: UnificationXref
id: 1058
db: ChemSpider

Reference/ChemSpider 389632
type: UnificationXref
id: 389632
db: ChemSpider

ReactionCatalysis139146
type: Catalysis
controller: 3'-Phosphoadenosine 5'-Phosphosulfate Synthetase
controlled: Reaction148807
control type: ACTIVATION

ReactionCatalysis139145
type: Catalysis
controller: Methionine--tRNA ligase, cytoplasmic
controlled: 6.1.1.10
control type: ACTIVATION

ReactionCatalysis139148
type: Catalysis
controller: Uncharacterized protein
controlled: Reaction148809
control type: ACTIVATION

Selenoamino Acid Metabolism
type: Pathway
pathway order: PathwayEnzymeReaction/2116358
pathway order: PathwayEnzymeReaction/2116359
pathway order: PathwayEnzymeReaction/2116354
pathway order: PathwayEnzymeReaction/2116355
pathway order: PathwayEnzymeReaction/2116356
pathway order: PathwayEnzymeReaction/2116357
pathway order: PathwaySubPathway/108901
pathway order: PathwaySubPathway/108902
pathway order: PathwaySubPathway/108903
pathway order: PathwaySubPathway/108904
pathway order: PathwaySubPathway/108905
pathway order: PathwayEnzymeReaction/2116361
pathway order: PathwayEnzymeReaction/2116351
pathway order: PathwayEnzymeReaction/2116362
pathway order: PathwayEnzymeReaction/2116352
pathway order: PathwayEnzymeReaction/2116363
pathway order: PathwayEnzymeReaction/2116353
pathway order: PathwayEnzymeReaction/2116364
pathway order: PathwayEnzymeReaction/2116360
pathway component: ReactionCatalysis139139
pathway component: ReactionCatalysis139138
pathway component: Reaction614
pathway component: 2.7.9.3
pathway component: 4.4.1.1
pathway component: 4.2.1.22
pathway component: 3.3.1.1
pathway component: 2.1.1.-
pathway component: 2.5.1.6
pathway component: 6.1.1.10
pathway component: Reaction148807
pathway component: Alanine Metabolism
pathway component: Reaction148808
pathway component: Reaction148809
pathway component: Glutamate Metabolism
pathway component: D-Arginine and D-Ornithine Metabolism
pathway component: ReactionCatalysis139146
pathway component: ReactionCatalysis139145
pathway component: ReactionCatalysis139148
pathway component: ReactionCatalysis139147
pathway component: Intestinal Digestion and Absorption
pathway component: 4.4.1.16
pathway component: Aspartate Metabolism
pathway component: Reaction2297
pathway component: ReactionCatalysis139142
pathway component: Reaction621
pathway component: ReactionCatalysis139141
pathway component: ReactionCatalysis139144
pathway component: ReactionCatalysis139143
pathway component: ReactionCatalysis139140
xref: Reference/SMPDB SMP0087423
xref: Reference/PathWhiz PW088442
organism: Caenorhabditis elegans

ReactionCatalysis139147
type: Catalysis
controller: 3'-Phosphoadenosine 5'-Phosphosulfate Synthetase
controlled: Reaction148808
control type: ACTIVATION

Reference/ChemSpider 129633
type: UnificationXref
id: 129633
db: ChemSpider

4.4.1.16
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000105 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006752 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001829 Cytoplasm/Stoichiometry/1.0
right: L-Alanine
right: Hydrogen selenide
spontaneous: false
EC number: 4.4.1.16
left: Selenocysteine
name: Selenocysteine → Hydrogen selenide + L-Alanine
conversion direction: LEFT_TO_RIGHT

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

Se-Methylselenocysteine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Se-Methylselenocysteine
name: SubPathwayOutput

Compound/PW C000003 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Ketobutyric acid
stoichiometric coefficient: 1.0

Se-Methylselenocysteine
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Se-Methylselenocysteine

Reference/ChEBI CHEBI 26078
type: UnificationXref
id: CHEBI:26078
db: ChEBI

Reference/HMDB HMDB0010716
type: UnificationXref
id: HMDB0010716
db: HMDB

Adenosylhomocysteinase
type: Protein
cellular location: Cytoplasm
entity reference: Adenosylhomocysteinase

ReactionCatalysis139142
type: Catalysis
controller: Adenosylhomocysteinase
controlled: 3.3.1.1
control type: ACTIVATION

ReactionCatalysis139141
type: Catalysis
controller: Cystathionine beta-synthase
controlled: 4.2.1.22
control type: ACTIVATION

ReactionCatalysis139144
type: Catalysis
controller: S-adenosylmethionine synthase
controlled: 2.5.1.6
control type: ACTIVATION

ReactionCatalysis139143
type: Catalysis
controller: Methyltransferase-like protein
controlled: 2.1.1.-
control type: ACTIVATION

Protein/14798 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Uncharacterized protein
stoichiometric coefficient: 2.0

ReactionCatalysis139140
type: Catalysis
controller: Cystathionine gamma-lyase
controlled: 4.4.1.1
control type: ACTIVATION

Reference/HMDB HMDB0006343
type: UnificationXref
id: HMDB0006343
db: HMDB

Compound/PW C040445 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Selenic acid
stoichiometric coefficient: 1.0

Selenocystathionine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 26630
xref: Reference/ChemSpider 88693
xref: Reference/PubChem-compound 98223
xref: Reference/KEGG Compound C05699
xref: Reference/HMDB HMDB0006343
xref: Reference/CAS 2196-58-9
chemical formula: C7H14N2O4Se
molecular weight: 270.01187
structure: ChemicalStructure/PW C002727

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

Reference/KEGG Compound C00041
type: UnificationXref
id: C00041
db: KEGG Compound

Selenocystathionine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Selenocystathionine

Selenomethionyl-tRNA(Met)
type: RnaReference
xref: Reference/ChEBI CHEBI 9100
organism: Caenorhabditis elegans

Reference/ChEBI CHEBI 29173
type: UnificationXref
id: CHEBI:29173
db: ChEBI

Reference/ChemSpider 30785505
type: UnificationXref
id: 30785505
db: ChemSpider

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])(=O)OP([O-])([O-])=O

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Methyltransferase-like protein
type: Protein
cellular location: Cytoplasm
entity reference: Methyltransferase-like protein

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C006724
type: ChemicalStructure
structure format: SMILES
structure data: C[Se]CC(NC(=O)CCC(N)C(O)=O)C(O)=O

Reaction2297
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002019 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002066 Cytosol/Stoichiometry/1.0
right: Selenomethionine
spontaneous: true
left: Selenohomocysteine
name: Selenohomocysteine → Selenomethionine
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 14375
type: UnificationXref
id: 14375
db: ChemSpider

Unknown
type: ProteinReference
organism: Caenorhabditis elegans

Reference/ChemSpider 14376
type: UnificationXref
id: 14376
db: ChemSpider

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Phosphoroselenoic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 29269
xref: Reference/HMDB HMDB0003840
xref: Reference/KEGG Compound C05172
xref: Reference/PubChem-compound 1092
xref: Reference/ChemSpider 1061
xref: Reference/CAS 25758-66-1
chemical formula: H3O3PSe
molecular weight: 161.8985
structure: ChemicalStructure/PW C001977

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc AMMONIA
type: UnificationXref
id: AMMONIA
db: BioCyc

ChemicalStructure/PW C000035
type: ChemicalStructure
structure format: SMILES
structure data: N

ChemicalStructure/PW C000034
type: ChemicalStructure
structure format: SMILES

Reference/CAS 26046-90-2
type: UnificationXref
id: 26046-90-2
db: CAS

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine diphosphate

Reference/PubChem-compound 533
type: UnificationXref
id: 533
db: PubChem-compound

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/KEGG Compound C00065
type: UnificationXref
id: C00065
db: KEGG Compound

Reference/CAS 58-61-7
type: UnificationXref
id: 58-61-7
db: CAS

Pyrophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pyrophosphate

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

Reference/ChEBI CHEBI 29269
type: UnificationXref
id: CHEBI:29269
db: ChEBI

Ammonia
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Ammonia

Reference/HMDB HMDB0000161
type: UnificationXref
id: HMDB0000161
db: HMDB

Protein/14817 Cytoplasm/Stoichiometry/4.0
type: Stoichiometry
physical entity: Adenosylhomocysteinase
stoichiometric coefficient: 4.0

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

L-Alanine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00041
xref: Reference/ChemSpider 5735
xref: Reference/ChEBI CHEBI 16977
xref: Reference/BioCyc L-ALPHA-ALANINE
xref: Reference/HMDB HMDB0000161
xref: Reference/CAS 56-41-7
xref: Reference/PubChem-compound 5950
chemical formula: C3H7NO2
molecular weight: 89.047676
structure: ChemicalStructure/PW C000105

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Reference/UniProt Q22501
type: UnificationXref
id: Q22501
db: UniProt

Reference/ChemSpider 979
type: UnificationXref
id: 979
db: ChemSpider

Reference/CAS 25758-66-1
type: UnificationXref
id: 25758-66-1
db: CAS

Compound/PW C000105 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Alanine
stoichiometric coefficient: 1.0

ChemicalStructure/PW C006752
type: ChemicalStructure
structure format: SMILES
structure data: [SeH2]

Phosphoric acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/ChEBI CHEBI 26078
xref: Reference/CAS 7664-38-2
xref: Reference/PubChem-compound 1004
xref: Reference/ChemSpider 979
xref: Reference/HMDB HMDB0002142
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001441

Glutamate Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108903
pathway component: SubPathwayInteraction108903
xref: Reference/SMPDB SMP0000072
xref: Reference/PathWhiz PW000003
name: SubPathway

Reference/HMDB HMDB0000051
type: UnificationXref
id: HMDB0000051
db: HMDB

Reference/HMDB HMDB0000050
type: UnificationXref
id: HMDB0000050
db: HMDB

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Compound/PW C006760 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Se-Adenosylselenomethionine
stoichiometric coefficient: 1.0

Compound/PW C002067 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Selenocystine
stoichiometric coefficient: 1.0

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

ChemicalStructure/PW C006759
type: ChemicalStructure
structure format: SMILES

Reference/UniProt P50305
type: UnificationXref
id: P50305
db: UniProt

2-Ketobutyric acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 30831
xref: Reference/HMDB HMDB0000005
xref: Reference/CAS 600-18-0
xref: Reference/ChemSpider 57
xref: Reference/KEGG Compound C00109
xref: Reference/PubChem-compound 58
xref: Reference/BioCyc 2-OXOBUTANOATE
chemical formula: C4H6O3
molecular weight: 102.03169
structure: ChemicalStructure/PW C000003

ChemicalStructure/PW C006761
type: ChemicalStructure
structure format: SMILES
structure data: [O-][Se]([O-])=O

ChemicalStructure/PW C006760
type: ChemicalStructure
structure format: SMILES

L-Serine
type: SmallMoleculeReference
xref: Reference/ChemSpider 5736
xref: Reference/ChEBI CHEBI 17115
xref: Reference/CAS 56-45-1
xref: Reference/KEGG Compound C00065
xref: Reference/PubChem-compound 5951
xref: Reference/HMDB HMDB0000187
xref: Reference/BioCyc SER
chemical formula: C3H7NO3
molecular weight: 105.042595
structure: ChemicalStructure/PW C000120

Hydrogen selenide
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Hydrogen selenide

Reference/HMDB HMDB0000187
type: UnificationXref
id: HMDB0000187
db: HMDB

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Reference/HMDB HMDB0060694
type: UnificationXref
id: HMDB0060694
db: HMDB

Reference/UniProt Q19434
type: UnificationXref
id: Q19434
db: UniProt

Uncharacterized protein
type: Protein
cellular location: Cytoplasm
entity reference: Uncharacterized protein

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

Reference/ChemSpider 518
type: UnificationXref
id: 518
db: ChemSpider

Compound/PW C006759 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Se-Adenosylselenohomocysteine
stoichiometric coefficient: 1.0

Putative cystathionine gamma-lyase 2
type: Protein
cellular location: Cytoplasm
entity reference: Putative cystathionine gamma-lyase 2

RNA/10 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Selenomethionyl-tRNA(Met)
stoichiometric coefficient: 1.0

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Compound/PW C001829 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Selenocysteine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 18170
type: UnificationXref
id: CHEBI:18170
db: ChEBI

Reference/ChemSpider 54923
type: UnificationXref
id: 54923
db: ChemSpider

ChemicalStructure/PW C002019
type: ChemicalStructure
structure format: SMILES
structure data: C[Se]CCC(N)C(O)=O

Selenomethionine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Selenomethionine

ChemicalStructure/PW C006747
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C05684
type: UnificationXref
id: C05684
db: KEGG Compound

Reference/PubChem-compound 98223
type: UnificationXref
id: 98223
db: PubChem-compound

Reference/HMDB HMDB0002142
type: UnificationXref
id: HMDB0002142
db: HMDB

Compound/PW C006747 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Phosphoadenylylselenate
stoichiometric coefficient: 1.0

tRNA(Met)
type: Rna
cellular location: Cytoplasm
entity reference: tRNA(Met)

Reference/KEGG Compound C05689
type: UnificationXref
id: C05689
db: KEGG Compound

Reference/KEGG Compound C05686
type: UnificationXref
id: C05686
db: KEGG Compound

Reference/KEGG Compound C05688
type: UnificationXref
id: C05688
db: KEGG Compound

Reference/KEGG Compound C05692
type: UnificationXref
id: C05692
db: KEGG Compound

Reference/KEGG Compound C05695
type: UnificationXref
id: C05695
db: KEGG Compound

Reference/KEGG Compound C05691
type: UnificationXref
id: C05691
db: KEGG Compound

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Ammonia
type: SmallMoleculeReference
xref: Reference/BioCyc AMMONIA
xref: Reference/CAS 7664-41-7
xref: Reference/HMDB HMDB0000051
xref: Reference/PubChem-compound 222
xref: Reference/KEGG Compound C00014
xref: Reference/ChEBI CHEBI 16134
xref: Reference/ChemSpider 217
chemical formula: H3N
molecular weight: 17.026548
structure: ChemicalStructure/PW C000035

Adenosine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 60961
xref: Reference/ChEBI CHEBI 16335
xref: Reference/ChemSpider 54923
xref: Reference/HMDB HMDB0000050
xref: Reference/CAS 58-61-7
xref: Reference/KEGG Compound C00212
xref: Reference/BioCyc ADENOSINE
chemical formula: C10H13N5O4
molecular weight: 267.09674
structure: ChemicalStructure/PW C000034

S-adenosylmethionine synthase
type: Complex
component stoichiometry: Protein/14826 Cytoplasm/Stoichiometry/2.0
component stoichiometry: Protein/10857 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Probable S-adenosylmethionine synthase 3
component: Unknown

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

D-Arginine and D-Ornithine Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108905
pathway component: SubPathwayInteraction108905
xref: Reference/SMPDB SMP0000036
xref: Reference/PathWhiz PW000019
name: SubPathway

Compound/Generic8 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: R
stoichiometric coefficient: 1.0

Reference/CAS 14124-67-5
type: UnificationXref
id: 14124-67-5
db: CAS

Compound/PW C006752 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen selenide
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/PubChem-compound 1004
type: UnificationXref
id: 1004
db: PubChem-compound

Reference/KEGG Compound C05697
type: UnificationXref
id: C05697
db: KEGG Compound

Reference/KEGG Compound C05696
type: UnificationXref
id: C05696
db: KEGG Compound

Reference/KEGG Compound C05699
type: UnificationXref
id: C05699
db: KEGG Compound

Reference/KEGG Compound C05698
type: UnificationXref
id: C05698
db: KEGG Compound

Reference/KEGG Compound C05335
type: UnificationXref
id: C05335
db: KEGG Compound

Reference/ChEBI CHEBI 3274
type: UnificationXref
id: CHEBI:3274
db: ChEBI

Water
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Water

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Reference/PubChem-compound 58
type: UnificationXref
id: 58
db: PubChem-compound

ChemicalStructure/PW C002727
type: ChemicalStructure
structure format: SMILES
structure data: NC(CC[Se]CC(N)C(O)=O)C(O)=O

Reference/ChemSpider 88693
type: UnificationXref
id: 88693
db: ChemSpider

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Alanine Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108904
pathway component: SubPathwayInteraction108904
xref: Reference/PathWhiz PW000001
xref: Reference/SMPDB SMP0000055
name: SubPathway

Adenosylhomocysteinase
type: Complex
component stoichiometry: Protein/14817 Cytoplasm/Stoichiometry/4.0
cellular location: Cytoplasm
component: Adenosylhomocysteinase

Reference/ChEBI CHEBI 27812
type: UnificationXref
id: CHEBI:27812
db: ChEBI

Adenylylselenate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenylylselenate

Compound/PW C002019 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Selenomethionine
stoichiometric coefficient: 1.0

R
type: SmallMolecule
cellular location: Cytoplasm
entity reference: R

Reference/BioCyc SER
type: UnificationXref
id: SER
db: BioCyc

Aspartate Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108902
pathway component: SubPathwayInteraction108902
xref: Reference/PathWhiz PW000002
xref: Reference/SMPDB SMP0000067
name: SubPathway

Reference/BioCyc SELENOMETHIONINE
type: UnificationXref
id: SELENOMETHIONINE
db: BioCyc

Reference/CAS 600-18-0
type: UnificationXref
id: 600-18-0
db: CAS

Reference/PubChem-compound 16682731
type: UnificationXref
id: 16682731
db: PubChem-compound

Reference/SMPDB SMP0087423
type: UnificationXref
id: SMP0087423
db: SMPDB

Reference/UniProt P27604
type: UnificationXref
id: P27604
db: UniProt

Reference/ChEBI CHEBI 16977
type: UnificationXref
id: CHEBI:16977
db: ChEBI

Selenite
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Selenite
name: SubPathwayOutput

Reference/HMDB HMDB0011104
type: UnificationXref
id: HMDB0011104
db: HMDB

R
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17792

Reference/BioCyc L-SELENOCYSTEINE
type: UnificationXref
id: L-SELENOCYSTEINE
db: BioCyc

CH3-R
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 3274

Reference/ChemSpider 217
type: UnificationXref
id: 217
db: ChemSpider

Reference/HMDB HMDB0003840
type: UnificationXref
id: HMDB0003840
db: HMDB

Reference/HMDB HMDB0003966
type: UnificationXref
id: HMDB0003966
db: HMDB

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Reference/HMDB HMDB0011110
type: UnificationXref
id: HMDB0011110
db: HMDB

Reference/CAS 1464-43-3
type: UnificationXref
id: 1464-43-3
db: CAS

Reference/ChEBI CHEBI 16503
type: UnificationXref
id: CHEBI:16503
db: ChEBI

Reference/HMDB HMDB0011118
type: UnificationXref
id: HMDB0011118
db: HMDB

Reference/HMDB HMDB0011117
type: UnificationXref
id: HMDB0011117
db: HMDB

Selenomethionine
type: SmallMoleculeReference
xref: Reference/BioCyc SELENOMETHIONINE
xref: Reference/ChemSpider 14375
xref: Reference/HMDB HMDB0003966
xref: Reference/PubChem-compound 15103
xref: Reference/CAS 1464-42-2
xref: Reference/KEGG Compound C05335
xref: Reference/ChEBI CHEBI 27585
chemical formula: C5H11NO2Se
molecular weight: 196.9955
structure: ChemicalStructure/PW C002019

Reference/UniProt Q20970
type: UnificationXref
id: Q20970
db: UniProt

γ-Glutamyl-Se-methylselenocysteine
type: SmallMolecule
cellular location: Cell Membrane
entity reference: γ-Glutamyl-Se-methylselenocysteine

Reference/CAS 7664-41-7
type: UnificationXref
id: 7664-41-7
db: CAS

Reference/SMPDB SMP0000055
type: UnificationXref
id: SMP0000055
db: SMPDB

Reference/PubChem-compound 60961
type: UnificationXref
id: 60961
db: PubChem-compound

Reaction614
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002067 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001829 Cytoplasm/Stoichiometry/1.0
right: Selenocystine
spontaneous: true
left: Selenocysteine
name: Selenocysteine → Selenocystine
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000105
type: ChemicalStructure
structure format: SMILES
structure data: C[C@H](N)C(O)=O

Compound/PW C002727 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Selenocystathionine
stoichiometric coefficient: 1.0

Reference/PathWhiz PW088442
type: UnificationXref
id: PW088442
db: PathWhiz

Reference/PubChem-compound 5950
type: UnificationXref
id: 5950
db: PubChem-compound

Reference/PubChem-compound 222
type: UnificationXref
id: 222
db: PubChem-compound

Reference/PubChem-compound 5951
type: UnificationXref
id: 5951
db: PubChem-compound

ChemicalStructure/PW C001441
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/PubChem-compound 440763
type: UnificationXref
id: 440763
db: PubChem-compound

Cysteine synthase 1
type: Protein
cellular location: Cytoplasm
entity reference: Cysteine synthase 1

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: O7P2
molecular weight: 173.91193
structure: ChemicalStructure/PW C000170

Reference/PubChem-compound 440760
type: UnificationXref
id: 440760
db: PubChem-compound

Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/PubChem-compound 25076
type: UnificationXref
id: 25076
db: PubChem-compound

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/HMDB HMDB0011119
type: UnificationXref
id: HMDB0011119
db: HMDB

Reference/SMPDB SMP0000067
type: UnificationXref
id: SMP0000067
db: SMPDB

Selenomethionine
type: SmallMolecule
cellular location: Cytosol
entity reference: Selenomethionine

Compound/PW C002063 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenylylselenate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 440758
type: UnificationXref
id: 440758
db: PubChem-compound

3-Phosphoadenylylselenate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 3-Phosphoadenylylselenate

Compound/Generic9 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: CH3-R
stoichiometric coefficient: 1.0

Reference/SMPDB SMP0000072
type: UnificationXref
id: SMP0000072
db: SMPDB

Reference/ChEBI CHEBI 26630
type: UnificationXref
id: CHEBI:26630
db: ChEBI

ChemicalStructure/PW C000120
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CO)C(O)=O

Reference/ChEBI CHEBI 2485
type: UnificationXref
id: CHEBI:2485
db: ChEBI

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Compound/PW C002019 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Selenomethionine
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Reference/HMDB HMDB0000005
type: UnificationXref
id: HMDB0000005
db: HMDB

ChemicalStructure/PW C000003
type: ChemicalStructure
structure format: SMILES
structure data: CCC(=O)C(O)=O

γ-Glutamyl-Se-methylselenocysteine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C05695
xref: Reference/HMDB HMDB0010716
xref: Reference/PubChem-compound 440760
xref: Reference/ChemSpider 389629
chemical formula: C9H16N2O5Se
molecular weight: 312.02243
structure: ChemicalStructure/PW C006724

Reaction621
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040445 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006761 Cytoplasm/Stoichiometry/1.0
right: Selenic acid
spontaneous: true
left: Selenite
name: Selenite → Selenic acid
conversion direction: LEFT_TO_RIGHT

Selenocysteine lyase
type: Complex
component stoichiometry: Protein/14798 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Uncharacterized protein

Selenic acid
type: SmallMoleculeReference
xref: Reference/ChemSpider 1058
xref: Reference/HMDB HMDB0060694
xref: Reference/CAS 7783-08-6
xref: Reference/ChEBI CHEBI 18170
xref: Reference/KEGG Compound C05697
xref: Reference/PubChem-compound 1089
chemical formula: H2O4Se
molecular weight: 145.91183
structure: ChemicalStructure/PW C040445

Reference/PubChem-compound 1090
type: UnificationXref
id: 1090
db: PubChem-compound

Reference/PubChem-compound 1092
type: UnificationXref
id: 1092
db: PubChem-compound

Reference/ChEBI CHEBI 30831
type: UnificationXref
id: CHEBI:30831
db: ChEBI

Selenocysteine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Selenocysteine
name: SubPathwayOutput

Reference/KEGG Compound C05172
type: UnificationXref
id: C05172
db: KEGG Compound

Compound/PW C002064 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Se-Methylselenocysteine
stoichiometric coefficient: 1.0

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

SubPathwayInteraction108902
type: Interaction
name: SubPathwayReaction
name: SubPathway108902Reaction
participant: L-Alanine

SubPathwayInteraction108903
type: Interaction
name: SubPathway108903Reaction
name: SubPathwayReaction
participant: L-Alanine

ChemicalStructure/PW C001829
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](C[SeH])C(O)=O

SubPathwayInteraction108904
type: Interaction
name: SubPathway108904Reaction
name: SubPathwayReaction
participant: L-Alanine

SubPathwayInteraction108905
type: Interaction
name: SubPathwayReaction
name: SubPathway108905Reaction
participant: L-Alanine

Reference/CAS 7783-08-6
type: UnificationXref
id: 7783-08-6
db: CAS

SubPathwayInteraction108901
type: Interaction
name: SubPathway108901Reaction
name: SubPathwayReaction
participant: Selenocysteine
participant: Selenite
participant: Se-Methylselenocysteine

Protein/10857 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1089
type: UnificationXref
id: 1089
db: PubChem-compound

Se-Methylselenocysteine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 27812
xref: Reference/ChemSpider 129633
xref: Reference/KEGG Compound C05689
xref: Reference/CAS 26046-90-2
xref: Reference/HMDB HMDB0004113
xref: Reference/PubChem-compound 147004
chemical formula: C4H9NO2Se
molecular weight: 182.97984
structure: ChemicalStructure/PW C002064

Selenohomocysteine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 440763
xref: Reference/ChemSpider 389632
xref: Reference/HMDB HMDB0004119
xref: Reference/CAS 29412-93-9
xref: Reference/BioCyc SELENOHOMOCYSTEINE
xref: Reference/KEGG Compound C05698
chemical formula: C4H9NO2Se
molecular weight: 182.97984
structure: ChemicalStructure/PW C002066

Selenocystine
type: SmallMoleculeReference
xref: Reference/CAS 1464-43-3
xref: Reference/KEGG Compound C05704
xref: Reference/ChemSpider 14376
xref: Reference/PubChem-compound 15104
xref: Reference/HMDB HMDB0004122
xref: Reference/ChEBI CHEBI 28553
chemical formula: C6H12N2O4Se2
molecular weight: 335.91275
structure: ChemicalStructure/PW C002067

Caenorhabditis elegans
type: BioSource
xref: Reference/TAXONOMY 6239

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Compound/PW C000034 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine
stoichiometric coefficient: 1.0

Adenylylselenate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 2485
xref: Reference/ChemSpider 389628
xref: Reference/PubChem-compound 440758
xref: Reference/KEGG Compound C05686
xref: Reference/HMDB HMDB0004112
chemical formula: C10H14N5O10PSe
molecular weight: 474.96436
structure: ChemicalStructure/PW C002063

Selenomethionyl-tRNA(Met)
type: Rna
cellular location: Cytoplasm
entity reference: Selenomethionyl-tRNA(Met)

Reference/ChEBI CHEBI 16633
type: UnificationXref
id: CHEBI:16633
db: ChEBI

Reference/TAXONOMY 6239
type: UnificationXref
id: 6239
db: TAXONOMY

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Se-Adenosylselenohomocysteine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Se-Adenosylselenohomocysteine

Reference/UniProt Q93244
type: UnificationXref
id: Q93244
db: UniProt

3-Phosphoadenylylselenate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24892762
xref: Reference/HMDB HMDB0011104
xref: Reference/ChEBI CHEBI 28450
xref: Reference/ChemSpider 30785505
xref: Reference/KEGG Compound C05696
chemical formula: C10H15N5O13P2Se
molecular weight: 554.93066
structure: ChemicalStructure/PW C006747

Compound/PW C001441 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoric acid
stoichiometric coefficient: 1.0

Hydrogen selenide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0011110
xref: Reference/PubChem-compound 533
xref: Reference/CAS 7783-07-5
xref: Reference/ChEBI CHEBI 16503
xref: Reference/KEGG Compound C01528
xref: Reference/ChemSpider 518
chemical formula: H2Se
molecular weight: 81.932175
structure: ChemicalStructure/PW C006752

Methionine--tRNA ligase, cytoplasmic
type: Protein
cellular location: Cytoplasm
entity reference: Methionine--tRNA ligase, cytoplasmic

Reference/CAS 1464-42-2
type: UnificationXref
id: 1464-42-2
db: CAS

Uncharacterized protein
type: ProteinReference
xref: Reference/UniProt Q19434
organism: Caenorhabditis elegans

Protein/14826 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Probable S-adenosylmethionine synthase 3
stoichiometric coefficient: 2.0

Reference/CAS 7783-07-5
type: UnificationXref
id: 7783-07-5
db: CAS

Reference/UniProt P55216
type: UnificationXref
id: P55216
db: UniProt

Reference/BioCyc SELENOHOMOCYSTEINE
type: UnificationXref
id: SELENOHOMOCYSTEINE
db: BioCyc

Se-Adenosylselenohomocysteine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C05692
xref: Reference/ChemSpider 17615371
xref: Reference/HMDB HMDB0011117
xref: Reference/PubChem-compound 16682731
chemical formula: C14H20N6O5Se
molecular weight: 432.06604
structure: ChemicalStructure/PW C006759

Phosphoric acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphoric acid

Reference/PubChem-compound 15103
type: UnificationXref
id: 15103
db: PubChem-compound

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Reference/PubChem-compound 15104
type: UnificationXref
id: 15104
db: PubChem-compound

Selenite
type: SmallMoleculeReference
xref: Reference/ChemSpider 1059
xref: Reference/KEGG Compound C05684
xref: Reference/PubChem-compound 1090
xref: Reference/HMDB HMDB0011119
xref: Reference/ChEBI CHEBI 18212
xref: Reference/CAS 14124-67-5
chemical formula: O3Se
molecular weight: 127.90127
structure: ChemicalStructure/PW C006761

Reference/SMPDB SMP0000036
type: UnificationXref
id: SMP0000036
db: SMPDB

Se-Adenosylselenomethionine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C05691
xref: Reference/PubChem-compound 24892761
xref: Reference/HMDB HMDB0011118
chemical formula: C15H23N6O5Se
molecular weight: 447.0895
structure: ChemicalStructure/PW C006760

Probable selenide, water dikinase
type: Protein
cellular location: Cytoplasm
entity reference: Probable selenide, water dikinase

Uncharacterized protein
type: ProteinReference
xref: Reference/UniProt V6CLP9
organism: Caenorhabditis elegans

Reference/ChEBI CHEBI 16335
type: UnificationXref
id: CHEBI:16335
db: ChEBI

ChemicalStructure/PW C001977
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=[Se]

Reference/CAS 29412-93-9
type: UnificationXref
id: 29412-93-9
db: CAS

2.7.9.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001977 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006752 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001441 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Cytoplasm/Stoichiometry/1.0
right: Adenosine monophosphate
right: Phosphoroselenoic acid
right: Phosphoric acid
spontaneous: false
EC number: 2.7.9.3
left: Water
left: Adenosine triphosphate
left: Hydrogen selenide
name: Adenosine triphosphate + Hydrogen selenide + Water ↔ Adenosine monophosphate + Phosphoric acid + Phosphoroselenoic acid
conversion direction: REVERSIBLE

4.4.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000035 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001829 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002727 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000003 Cytoplasm/Stoichiometry/1.0
right: Selenocysteine
right: 2-Ketobutyric acid
right: Ammonia
spontaneous: false
EC number: 4.4.1.1
left: Water
left: Selenocystathionine
name: Selenocystathionine + Water → 2-Ketobutyric acid + Ammonia + Selenocysteine
conversion direction: LEFT_TO_RIGHT

4.2.1.22
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000120 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002066 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002727 Cytoplasm/Stoichiometry/1.0
right: Water
right: Selenocystathionine
spontaneous: false
EC number: 4.2.1.22
left: Selenohomocysteine
left: L-Serine
name: L-Serine + Selenohomocysteine → Selenocystathionine + Water
conversion direction: LEFT_TO_RIGHT

Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

3.3.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002066 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006759 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000034 Cytoplasm/Stoichiometry/1.0
right: Selenohomocysteine
right: Adenosine
spontaneous: false
EC number: 3.3.1.1
left: Se-Adenosylselenohomocysteine
left: Water
name: Se-Adenosylselenohomocysteine + Water → Adenosine + Selenohomocysteine
conversion direction: LEFT_TO_RIGHT

2.1.1.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006759 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006760 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/Generic9 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/Generic8 Cytoplasm/Stoichiometry/1.0
right: CH3-R
right: Se-Adenosylselenohomocysteine
spontaneous: false
EC number: 2.1.1.-
left: Se-Adenosylselenomethionine
left: R
name: R + Se-Adenosylselenomethionine → CH3-R + Se-Adenosylselenohomocysteine
conversion direction: LEFT_TO_RIGHT

Reference/CAS 2196-58-9
type: UnificationXref
id: 2196-58-9
db: CAS

2.5.1.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002019 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001441 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006760 Cytoplasm/Stoichiometry/1.0
right: Se-Adenosylselenomethionine
right: Phosphoric acid
right: Pyrophosphate
spontaneous: false
EC number: 2.5.1.6
left: Selenomethionine
left: Water
left: Adenosine triphosphate
name: Adenosine triphosphate + Selenomethionine + Water → Phosphoric acid + Pyrophosphate + Se-Adenosylselenomethionine
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 147004
type: UnificationXref
id: 147004
db: PubChem-compound

6.1.1.10
type: BiochemicalReaction
participant stoichiometry: RNA/9 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: RNA/10 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002019 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Cytoplasm/Stoichiometry/1.0
right: Selenomethionyl-tRNA(Met)
right: Adenosine monophosphate
right: Pyrophosphate
spontaneous: false
EC number: 6.1.1.10
left: Selenomethionine
left: Adenosine triphosphate
left: tRNA(Met)
name: Adenosine triphosphate + Selenomethionine + tRNA(Met) → Adenosine monophosphate + Pyrophosphate + Selenomethionyl-tRNA(Met)
conversion direction: LEFT_TO_RIGHT

Reaction148807
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002063 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040445 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
right: Adenylylselenate
right: Pyrophosphate
spontaneous: false
left: Selenic acid
left: Adenosine triphosphate
name: Adenosine triphosphate + Selenic acid → Adenylylselenate + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Reaction148808
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002063 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006747 Cytoplasm/Stoichiometry/1.0
right: 3-Phosphoadenylylselenate
right: Adenosine diphosphate
spontaneous: false
left: Adenosine triphosphate
left: Adenylylselenate
name: Adenosine triphosphate + Adenylylselenate → 3-Phosphoadenylylselenate + Adenosine diphosphate
conversion direction: LEFT_TO_RIGHT

Reaction148809
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006724 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002064 Cell Membrane/Stoichiometry/1.0
right: γ-Glutamyl-Se-methylselenocysteine
spontaneous: false
left: Se-Methylselenocysteine
name: Se-Methylselenocysteine → γ-Glutamyl-Se-methylselenocysteine
conversion direction: LEFT_TO_RIGHT

Compound/PW C002066 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Selenohomocysteine
stoichiometric coefficient: 1.0

L-Alanine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Alanine
name: SubPathwayInput

Reference/PathWhiz PW000019
type: UnificationXref
id: PW000019
db: PathWhiz

Compound/PW C000032 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

Reference/BioCyc ADENOSINE
type: UnificationXref
id: ADENOSINE
db: BioCyc

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/CAS 56-45-1
type: UnificationXref
id: 56-45-1
db: CAS

Cystathionine gamma-lyase
type: Complex
component stoichiometry: Protein/14807 Cytoplasm/Stoichiometry/4.0
cellular location: Cytoplasm
component: Putative cystathionine gamma-lyase 2

Compound/PW C006761 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Selenite
stoichiometric coefficient: 1.0

Reference/ChemSpider 23436
type: UnificationXref
id: 23436
db: ChemSpider

Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17792
type: UnificationXref
id: CHEBI:17792
db: ChEBI

L-Serine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Serine

Reference/ChEBI CHEBI 27585
type: UnificationXref
id: CHEBI:27585
db: ChEBI

Reference/ChEBI CHEBI 28553
type: UnificationXref
id: CHEBI:28553
db: ChEBI

Reference/PathWhiz PW000002
type: UnificationXref
id: PW000002
db: PathWhiz

Reference/PathWhiz PW000001
type: UnificationXref
id: PW000001
db: PathWhiz

Uncharacterized protein
type: Protein
cellular location: Cell Membrane
entity reference: Uncharacterized protein

Reference/PathWhiz PW000003
type: UnificationXref
id: PW000003
db: PathWhiz

Selenic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Selenic acid

tRNA(Met)
type: RnaReference
xref: Reference/ChEBI CHEBI 29173
organism: Caenorhabditis elegans

Selenohomocysteine
type: SmallMolecule
cellular location: Cytosol
entity reference: Selenohomocysteine

Reference/UniProt Q23383
type: UnificationXref
id: Q23383
db: UniProt

Cystathionine beta-synthase
type: Complex
component stoichiometry: Protein/14811 Cytoplasm/Stoichiometry/4.0
cellular location: Cytoplasm
component: Cysteine synthase 1

2-Ketobutyric acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 2-Ketobutyric acid

Selenocystine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Selenocystine