Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Compound/PW C001765 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lactaldehyde
stoichiometric coefficient: 1.0

NADP-dependent malic enzyme
type: Complex
component stoichiometry: Protein/16352 Cytoplasm/Stoichiometry/4.0
cellular location: Cytoplasm
component: Malic enzyme

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

Reference/ChEBI CHEBI 17460
type: UnificationXref
id: CHEBI:17460
db: ChEBI

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/ChemSpider 96860
type: UnificationXref
id: 96860
db: ChemSpider

Reference/ChemSpider 388473
type: UnificationXref
id: 388473
db: ChemSpider

Reference/ChemSpider 388353
type: UnificationXref
id: 388353
db: ChemSpider

Compound/PW C000164 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 30797
type: UnificationXref
id: CHEBI:30797
db: ChEBI

Ferrocytochrome c
type: Protein
cellular location: Mitochondrion
entity reference: Ferrocytochrome c

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

Compound/PW C000986 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine triphosphate
stoichiometric coefficient: 1.0

Reference/UniProt O17626
type: UnificationXref
id: O17626
db: UniProt

Reference/HMDB HMDB0006878
type: UnificationXref
id: HMDB0006878
db: HMDB

Compound/PW C000143 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001066
type: UnificationXref
id: HMDB0001066
db: HMDB

Reference/ChemSpider 388368
type: UnificationXref
id: 388368
db: ChemSpider

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

Reference/BioCyc OXALACETIC ACID
type: UnificationXref
id: OXALACETIC_ACID
db: BioCyc

Reference/UniProt O17732
type: UnificationXref
id: O17732
db: UniProt

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/PubChem-compound 440018
type: UnificationXref
id: 440018
db: PubChem-compound

Reference/PathWhiz PW000051
type: UnificationXref
id: PW000051
db: PathWhiz

Unknown
type: Protein
cellular location: Cytoplasm
entity reference: Unknown

Reference/UniProt Q9XXJ1
type: UnificationXref
id: Q9XXJ1
db: UniProt

Acetoacetyl-CoA
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Acetoacetyl-CoA

Pyruvate dehydrogenase E1
type: Complex
component stoichiometry: Protein/14850 Mitochondrion/Stoichiometry/2.0
component stoichiometry: Protein/14845 Mitochondrion/Stoichiometry/2.0
cellular location: Mitochondrion
component: Probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial
component: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Reference/HMDB HMDB0006880
type: UnificationXref
id: HMDB0006880
db: HMDB

Reference/KEGG Compound C00579
type: UnificationXref
id: C00579
db: KEGG Compound

Reference/BioCyc D-LACTATE
type: UnificationXref
id: D-LACTATE
db: BioCyc

Reference/BioCyc HCO3
type: UnificationXref
id: HCO3
db: BioCyc

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Acetyl-CoA
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Acetyl-CoA

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/KEGG Compound C00332
type: UnificationXref
id: C00332
db: KEGG Compound

Acetaldehyde
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Acetaldehyde

Carbon dioxide
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Carbon dioxide

Guanosine triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Guanosine triphosphate

Reference/CAS 97-67-6
type: UnificationXref
id: 97-67-6
db: CAS

Alkyldihydroxyacetonephosphate synthase
type: ProteinReference
xref: Reference/UniProt O45218
organism: Caenorhabditis elegans

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

Reference/KEGG Compound C00227
type: UnificationXref
id: C00227
db: KEGG Compound

Compound/PW C000463 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen carbonate
stoichiometric coefficient: 1.0

Pyruvaldehyde
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pyruvaldehyde
name: SubPathwayInput

Dihydrolipoyl dehydrogenase, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Dihydrolipoyl dehydrogenase, mitochondrial

Reference/CAS 13015-87-7
type: UnificationXref
id: 13015-87-7
db: CAS

Reference/PathWhiz PW000157
type: UnificationXref
id: PW000157
db: PathWhiz

Compound/PW C000143 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00583
type: UnificationXref
id: C00583
db: KEGG Compound

2.7.1.40
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000180 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
right: Adenosine diphosphate
right: Phosphoenolpyruvic acid
spontaneous: false
EC number: 2.7.1.40
left: Pyruvic acid
left: Adenosine triphosphate
name: Adenosine triphosphate + Pyruvic acid ↔ Adenosine diphosphate + Phosphoenolpyruvic acid
conversion direction: REVERSIBLE

Reference/ChemSpider 945
type: UnificationXref
id: 945
db: ChemSpider

Reference/PathWhiz PW000151
type: UnificationXref
id: PW000151
db: PathWhiz

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reference/CAS 10326-41-7
type: UnificationXref
id: 10326-41-7
db: CAS

Guanosine diphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001201
xref: Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
xref: Reference/CAS 146-91-8
xref: Reference/PubChem-compound 8977
xref: Reference/ChEBI CHEBI 17552
xref: Reference/ChemSpider 8630
xref: Reference/KEGG Compound C00035
chemical formula: C10H15N5O11P2
molecular weight: 443.02432
structure: ChemicalStructure/PW C000936

Reference/ChEBI CHEBI 17694
type: UnificationXref
id: CHEBI:17694
db: ChEBI

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

Compound/PW C000148 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxalacetic acid
stoichiometric coefficient: 1.0

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Uncharacterized protein
type: ProteinReference
xref: Reference/UniProt Q9XXJ1
organism: Caenorhabditis elegans

Protein/15364 Mitochondrion/Stoichiometry/4.0
type: Stoichiometry
physical entity: ALdehyde deHydrogenase
stoichiometric coefficient: 4.0

Reference/CAS 138-08-9
type: UnificationXref
id: 138-08-9
db: CAS

Compound/PW C000784 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetaldehyde
stoichiometric coefficient: 1.0

Guanosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15996
xref: Reference/ChemSpider 6569
xref: Reference/KEGG Compound C00044
xref: Reference/PubChem-compound 6830
xref: Reference/HMDB HMDB0001273
xref: Reference/CAS 86-01-1
xref: Reference/BioCyc GTP
chemical formula: C10H16N5O14P3
molecular weight: 522.99066
structure: ChemicalStructure/PW C000986

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Dihydrolipoamide
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Dihydrolipoamide

Reference/PubChem-compound 124886
type: UnificationXref
id: 124886
db: PubChem-compound

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Compound/PW C000170 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/UniProt Q22100
type: UnificationXref
id: Q22100
db: UniProt

Reference/CAS 7664-38-2
type: UnificationXref
id: 7664-38-2
db: CAS

ReactionCatalysis139155
type: Catalysis
controller: Pyruvate carboxylase, mitochondrial
controlled: 6.4.1.1
control type: ACTIVATION

Pyruvate Metabolism
type: Pathway
pathway order: PathwayEnzymeReaction/2116666
pathway order: PathwayEnzymeReaction/2116667
pathway order: PathwayEnzymeReaction/2116668
pathway order: PathwayEnzymeReaction/2116669
pathway order: PathwayEnzymeReaction/2116662
pathway order: PathwayEnzymeReaction/2116663
pathway order: PathwayEnzymeReaction/2116664
pathway order: PathwayEnzymeReaction/2116665
pathway order: PathwaySubPathway/109009
pathway order: PathwayEnzymeReaction/2116660
pathway order: PathwayEnzymeReaction/2116661
pathway order: PathwayEnzymeReaction/2116655
pathway order: PathwaySubPathway/109013
pathway order: PathwayEnzymeReaction/2116656
pathway order: PathwaySubPathway/109012
pathway order: PathwayEnzymeReaction/2116657
pathway order: PathwaySubPathway/109015
pathway order: PathwayEnzymeReaction/2116658
pathway order: PathwaySubPathway/109014
pathway order: PathwayEnzymeReaction/2116651
pathway order: PathwayEnzymeReaction/2116652
pathway order: PathwayEnzymeReaction/2116653
pathway order: PathwaySubPathway/109011
pathway order: PathwayEnzymeReaction/2116654
pathway order: PathwaySubPathway/109010
pathway order: PathwayEnzymeReaction/2116659
pathway order: PathwayEnzymeReaction/2116670
pathway order: PathwayEnzymeReaction/2116671
pathway order: PathwayEnzymeReaction/2116650
pathway component: ReactionCatalysis139435
pathway component: ReactionCatalysis139438
pathway component: ReactionCatalysis139437
pathway component: ReactionCatalysis139432
pathway component: ReactionCatalysis139431
pathway component: ReactionCatalysis139434
pathway component: ReactionCatalysis139433
pathway component: ReactionCatalysis139439
pathway component: Valine, Leucine, and Isoleucine Degradation
pathway component: Ketone Body Metabolism
pathway component: ReactionCatalysis139155
pathway component: ReactionCatalysis139430
pathway component: ReactionCatalysis139154
pathway component: ReactionCatalysis139443
pathway component: ReactionCatalysis139442
pathway component: Reaction148815
pathway component: 6.4.1.1
pathway component: Glycolysis
pathway component: ReactionCatalysis139441
pathway component: Nicotinate and Nicotinamide Metabolism
pathway component: Glycine and Serine Metabolism
pathway component: 1.1.1.27
pathway component: 4.1.1.32
pathway component: Reaction149036
pathway component: 1.1.2.4
pathway component: 3.1.2.6
pathway component: 4.4.1.5
pathway component: Propanoate Metabolism
pathway component: Reaction149040
pathway component: 1.1.1.21
pathway component: 1.8.1.4
pathway component: Citric Acid Cycle
pathway component: ReactionCatalysis139425
pathway component: 2.3.1.12
pathway component: ReactionCatalysis139424
pathway component: Reaction149044
pathway component: ReactionCatalysis139427
pathway component: 2.3.1.9
pathway component: ReactionCatalysis139426
pathway component: 3.1.2.1
pathway component: ReactionCatalysis139388
pathway component: 3.6.1.7
pathway component: 1.2.1.3
pathway component: 6.2.1.1
pathway component: 2.7.1.40
pathway component: ReactionCatalysis139429
pathway component: ReactionCatalysis139428
pathway component: 1.2.4.1
xref: Reference/SMPDB SMP0087449

ReactionCatalysis139154
type: Catalysis
controller: Malate dehydrogenase
controlled: Reaction148815
control type: ACTIVATION

Phosphoenolpyruvic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphoenolpyruvic acid
name: SubPathwayOutput

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/ChEBI CHEBI 17158
type: UnificationXref
id: CHEBI:17158
db: ChEBI

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/KEGG Compound C00248
type: UnificationXref
id: C00248
db: KEGG Compound

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Uncharacterized protein
type: Protein
cellular location: Cytoplasm
entity reference: Uncharacterized protein

Compound/PW C001010 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Lactic acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

ChemicalStructure/PW C000936
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Pyruvic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Pyruvic acid

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/ChemSpider 1031
type: UnificationXref
id: 1031
db: ChemSpider

NADP
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NADP

Reference/CAS 598-35-6
type: UnificationXref
id: 598-35-6
db: CAS

Ferricytochrome c
type: Protein
cellular location: Mitochondrion
entity reference: Ferricytochrome c

Reference/HMDB HMDB0003052
type: UnificationXref
id: HMDB0003052
db: HMDB

Protein/14845 Mitochondrion/Stoichiometry/2.0
type: Stoichiometry
physical entity: Probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial
stoichiometric coefficient: 2.0

ChemicalStructure/PW C000905
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)C=O

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H28N7O14P2
molecular weight: 664.11694
structure: ChemicalStructure/PW C000721

Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 107689
type: UnificationXref
id: 107689
db: PubChem-compound

S-Lactoylglutathione
type: SmallMoleculeReference
xref: Reference/CAS 25138-66-3
xref: Reference/BioCyc S-LACTOYL-GLUTATHIONE
xref: Reference/KEGG Compound C03451
xref: Reference/ChemSpider 389032
xref: Reference/PubChem-compound 440018
xref: Reference/ChEBI CHEBI 15694
xref: Reference/HMDB HMDB0001066
chemical formula: C13H21N3O8S
molecular weight: 379.10495
structure: ChemicalStructure/PW C000841

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine triphosphate

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

D-Lactic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: D-Lactic acid

Reference/UniProt P52899
type: UnificationXref
id: P52899
db: UniProt

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Reference/CAS 3946-09-6
type: UnificationXref
id: 3946-09-6
db: CAS

Reference/KEGG Compound C00256
type: UnificationXref
id: C00256
db: KEGG Compound

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Reference/HMDB HMDB0006458
type: UnificationXref
id: HMDB0006458
db: HMDB

Phosphoenolypyruvate CarboxyKinase
type: Protein
cellular location: Cytoplasm
entity reference: Phosphoenolypyruvate CarboxyKinase

Pyruvate carboxylase 1
type: ProteinReference
xref: Reference/UniProt O17732
organism: Caenorhabditis elegans

S-Lactoylglutathione
type: SmallMolecule
cellular location: Cytoplasm
entity reference: S-Lactoylglutathione

Pyruvic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pyruvic acid
name: SubPathwayOutput
name: SubPathwayInput

Reference/CAS 25138-66-3
type: UnificationXref
id: 25138-66-3
db: CAS

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Acetyl adenylate
type: SmallMolecule
cellular location: Cytosol
entity reference: Acetyl adenylate

Reference/KEGG Compound C00149
type: UnificationXref
id: C00149
db: KEGG Compound

ReactionCatalysis139388
type: Catalysis
controller: Pyruvate kinase PKLR
controlled: 2.7.1.40
control type: ACTIVATION

Reference/KEGG Compound C00022
type: UnificationXref
id: C00022
db: KEGG Compound

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

Protein/10857 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 2.0

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

ChemicalStructure/PW C000911
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 26078
type: UnificationXref
id: CHEBI:26078
db: ChEBI

Reference/BioCyc ACET
type: UnificationXref
id: ACET
db: BioCyc

Uncharacterized protein
type: Protein
cellular location: Cytoplasm
entity reference: Uncharacterized protein

Reference/CAS 940-69-2
type: UnificationXref
id: 940-69-2
db: CAS

Acetyl-CoA acetyltransferase, mitochondrial
type: Complex
component stoichiometry: Protein/15162 Mitochondrion/Stoichiometry/4.0
cellular location: Mitochondrion
component: Acetyl-CoA acetyltransferase homolog, mitochondrial

Reference/BioCyc OXIDIZED-GLUTATHIONE
type: UnificationXref
id: OXIDIZED-GLUTATHIONE
db: BioCyc

Reference/PubChem-compound 769
type: UnificationXref
id: 769
db: PubChem-compound

Reference/KEGG Compound C00033
type: UnificationXref
id: C00033
db: KEGG Compound

Compound/PW C000784 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetaldehyde
stoichiometric coefficient: 1.0

Compound/PW C000164 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00036
type: UnificationXref
id: C00036
db: KEGG Compound

Reference/KEGG Compound C00035
type: UnificationXref
id: C00035
db: KEGG Compound

Reference/PubChem-compound 880
type: UnificationXref
id: 880
db: PubChem-compound

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C001142
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

Compound/PW C001099 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Compound/PW C001316 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

Reference/CAS 590-54-5
type: UnificationXref
id: 590-54-5
db: CAS

Reference/CAS 57-55-6
type: UnificationXref
id: 57-55-6
db: CAS

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

Pyruvate kinase PKLR
type: Complex
component stoichiometry: Protein/16154 Cytoplasm/Stoichiometry/4.0
cellular location: Cytoplasm
component: Pyruvate kinase

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])(=O)OP([O-])([O-])=O

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Aldehyde dehydrogenase, mitochondrial
type: Complex
component stoichiometry: Protein/15364 Mitochondrion/Stoichiometry/4.0
cellular location: Mitochondrion
component: ALdehyde deHydrogenase

Reference/KEGG Compound C00044
type: UnificationXref
id: C00044
db: KEGG Compound

Lactaldehyde
type: SmallMoleculeReference
xref: Reference/CAS 598-35-6
xref: Reference/KEGG Compound C00424
xref: Reference/ChemSpider 388368
xref: Reference/PubChem-compound 439231
xref: Reference/ChEBI CHEBI 18041
xref: Reference/HMDB HMDB0003052
xref: Reference/BioCyc LACTALD
chemical formula: C3H6O2
molecular weight: 74.03678
structure: ChemicalStructure/PW C001765

Reference/ChEBI CHEBI 18041
type: UnificationXref
id: CHEBI:18041
db: ChEBI

Reference/KEGG Compound C00288
type: UnificationXref
id: C00288
db: KEGG Compound

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 643
type: UnificationXref
id: 643
db: ChemSpider

Reference/BioCyc PHOSPHO-ENOL-PYRUVATE
type: UnificationXref
id: PHOSPHO-ENOL-PYRUVATE
db: BioCyc

Reference/KEGG Compound C00051
type: UnificationXref
id: C00051
db: KEGG Compound

Pyruvate kinase
type: ProteinReference
xref: Reference/UniProt Q3S1I8
organism: Caenorhabditis elegans

Compound/PW C001144 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Unknown
type: ProteinReference
organism: Caenorhabditis elegans

ChemicalStructure/PW C001151
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)OP(O)(O)=O

L-Malic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Malic acid

Reference/HMDB HMDB0000263
type: UnificationXref
id: HMDB0000263
db: HMDB

ChemicalStructure/PW C000180
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C(=C)OP(O)(O)=O

Ferricytochrome c
type: ProteinReference
xref: Reference/ChEBI CHEBI 15991
organism: Caenorhabditis elegans

Lipoamide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 863
xref: Reference/ChemSpider 840
xref: Reference/KEGG Compound C00248
xref: Reference/HMDB HMDB0000962
xref: Reference/BioCyc LIPOAMIDE
xref: Reference/CAS 940-69-2
xref: Reference/ChEBI CHEBI 17460
chemical formula: C8H15NOS2
molecular weight: 205.05951
structure: ChemicalStructure/PW C000769

Hydrogen carbonate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Hydrogen carbonate

Reference/BioCyc CPD-358
type: UnificationXref
id: CPD-358
db: BioCyc

Reference/PubChem-compound 663
type: UnificationXref
id: 663
db: PubChem-compound

Reference/ChemSpider 389703
type: UnificationXref
id: 389703
db: ChemSpider

Reference/CAS 78-98-8
type: UnificationXref
id: 78-98-8
db: CAS

Compound/PW C002750 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Lactaldehyde
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000029
type: ChemicalStructure
structure format: SMILES
structure data: CC(O)=O

ChemicalStructure/PW C000148
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC(=O)C(O)=O

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/ChEBI CHEBI 17167
type: UnificationXref
id: CHEBI:17167
db: ChEBI

Ferrocytochrome c
type: ProteinReference
xref: Reference/ChEBI CHEBI 16928
organism: Caenorhabditis elegans

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Reference/HMDB HMDB0000156
type: UnificationXref
id: HMDB0000156
db: HMDB

NAD
type: SmallMolecule
cellular location: Mitochondrion
entity reference: NAD

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C03451
type: UnificationXref
id: C03451
db: KEGG Compound

Compound/PW C000782 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydrolipoamide
stoichiometric coefficient: 1.0

Phosphoenolypyruvate CarboxyKinase
type: ProteinReference
xref: Reference/UniProt Q7JKI2
organism: Caenorhabditis elegans

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine diphosphate

Reference/HMDB HMDB0001484
type: UnificationXref
id: HMDB0001484
db: HMDB

Acetylphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Acetylphosphate

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/KEGG Compound C00186
type: UnificationXref
id: C00186
db: KEGG Compound

Reference/KEGG Compound C05993
type: UnificationXref
id: C05993
db: KEGG Compound

Pyrophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pyrophosphate

ChemicalStructure/PW C000164
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)C(O)=O

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

Reference/UniProt Q7JKI2
type: UnificationXref
id: Q7JKI2
db: UniProt

ChemicalStructure/PW C001010
type: ChemicalStructure
structure format: SMILES
structure data: C[C@@H](O)C(O)=O

ChemicalStructure/PW C001252
type: ChemicalStructure
structure format: SMILES
structure data: CC(O)CO

Reference/KEGG Compound C00074
type: UnificationXref
id: C00074
db: KEGG Compound

Protein/Generic17 Mitochondrion/Stoichiometry/2.0
type: Stoichiometry
physical entity: Ferricytochrome c
stoichiometric coefficient: 2.0

Acetaldehyde
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15343
xref: Reference/KEGG Compound C00084
xref: Reference/CAS 75-07-0
xref: Reference/BioCyc ACETALD
xref: Reference/ChemSpider 172
xref: Reference/PubChem-compound 177
xref: Reference/HMDB HMDB0000990
chemical formula: C2H4O
molecular weight: 44.026215
structure: ChemicalStructure/PW C000784

Dihydrolipoamide
type: SmallMoleculeReference
xref: Reference/ChemSpider 643
xref: Reference/CAS 3884-47-7
xref: Reference/KEGG Compound C00579
xref: Reference/PubChem-compound 663
xref: Reference/HMDB HMDB0000985
xref: Reference/BioCyc DIHYDROLIPOAMIDE
xref: Reference/ChEBI CHEBI 17694
chemical formula: C8H17NOS2
molecular weight: 207.07515
structure: ChemicalStructure/PW C000782

Reference/HMDB HMDB0000042
type: UnificationXref
id: HMDB0000042
db: HMDB

Reference/HMDB HMDB0001494
type: UnificationXref
id: HMDB0001494
db: HMDB

S-Acetyldihydrolipoamide-E
type: SmallMolecule
cellular location: Mitochondrion
entity reference: S-Acetyldihydrolipoamide-E

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Reference/ChemSpider 979
type: UnificationXref
id: 979
db: ChemSpider

Reference/ChemSpider 857
type: UnificationXref
id: 857
db: ChemSpider

Reference/BioCyc LACTALD
type: UnificationXref
id: LACTALD
db: BioCyc

D-Lactic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: D-Lactic acid

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Compound/PW C000940 Mitochondrion/Stoichiometry/2.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 2.0

Phosphoric acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/ChEBI CHEBI 26078
xref: Reference/CAS 7664-38-2
xref: Reference/PubChem-compound 1004
xref: Reference/ChemSpider 979
xref: Reference/HMDB HMDB0002142
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001441

Reference/KEGG Compound C00084
type: UnificationXref
id: C00084
db: KEGG Compound

Reference/KEGG Compound C00083
type: UnificationXref
id: C00083
db: KEGG Compound

Ketone Body Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway109015
pathway component: SubPathwayInteraction109015
xref: Reference/SMPDB SMP0000071
xref: Reference/PathWhiz PW000028
name: SubPathway

Protein/14907 Cytoplasm/Stoichiometry/4.0
type: Stoichiometry
physical entity: Pyruvate carboxylase 1
stoichiometric coefficient: 4.0

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Glutathione
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Glutathione

Malate dehydrogenase
type: ProteinReference
xref: Reference/UniProt Q9UAV5
organism: Caenorhabditis elegans

Reference/ChEBI CHEBI 42111
type: UnificationXref
id: CHEBI:42111
db: ChEBI

Compound/PW C000782 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydrolipoamide
stoichiometric coefficient: 1.0

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/ChEBI CHEBI 44897
type: UnificationXref
id: CHEBI:44897
db: ChEBI

Reference/BioCyc PYRUVATE
type: UnificationXref
id: PYRUVATE
db: BioCyc

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

Reference/UniProt Q18496
type: UnificationXref
id: Q18496
db: UniProt

Compound/PW C001316 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/BioCyc GTP
type: UnificationXref
id: GTP
db: BioCyc

NADP
type: SmallMolecule
cellular location: Mitochondrion
entity reference: NADP

Reference/ChemSpider 840
type: UnificationXref
id: 840
db: ChemSpider

Malic enzyme
type: ProteinReference
xref: Reference/UniProt Q9U296
organism: Caenorhabditis elegans

L-Lactic acid
type: SmallMoleculeReference
xref: Reference/CAS 79-33-4
xref: Reference/ChEBI CHEBI 422
xref: Reference/HMDB HMDB0000190
xref: Reference/PubChem-compound 107689
xref: Reference/KEGG Compound C00186
xref: Reference/BioCyc L-LACTATE
xref: Reference/ChemSpider 96860
chemical formula: C3H6O3
molecular weight: 90.03169
structure: ChemicalStructure/PW C000122

Uncharacterized protein
type: ProteinReference
xref: Reference/UniProt O17626
organism: Caenorhabditis elegans

Reference/HMDB HMDB0001273
type: UnificationXref
id: HMDB0001273
db: HMDB

Reference/PubChem-compound 863
type: UnificationXref
id: 863
db: PubChem-compound

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

Reference/BioCyc LIPOAMIDE
type: UnificationXref
id: LIPOAMIDE
db: BioCyc

Reference/HMDB HMDB0000190
type: UnificationXref
id: HMDB0000190
db: HMDB

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

Compound/PW C000721 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

S-Acetyldihydrolipoamide-E
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24906332
xref: Reference/KEGG Compound C16255
xref: Reference/HMDB HMDB0006878
xref: Reference/ChEBI CHEBI 50623
xref: Reference/ChemSpider 21865772
chemical formula: C10H19NO2S2
molecular weight: 249.08572
structure: ChemicalStructure/PW C002986

Acetyl adenylate
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL AMP
xref: Reference/ChemSpider 389703
xref: Reference/CAS 13015-87-7
xref: Reference/ChEBI CHEBI 37666
xref: Reference/PubChem-compound 440867
xref: Reference/HMDB HMDB0006880
xref: Reference/KEGG Compound C05993
chemical formula: C12H16N5O8P
molecular weight: 389.07364
structure: ChemicalStructure/PW C002987

Reference/UniProt Q9UAV5
type: UnificationXref
id: Q9UAV5
db: UniProt

Reference/ChemSpider 21865772
type: UnificationXref
id: 21865772
db: ChemSpider

Reference/PubChem-compound 10663
type: UnificationXref
id: 10663
db: PubChem-compound

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Reference/HMDB HMDB0001167
type: UnificationXref
id: HMDB0001167
db: HMDB

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

D-Lactaldehyde
type: SmallMoleculeReference
xref: Reference/BioCyc CPD-358
xref: Reference/HMDB HMDB0006458
xref: Reference/KEGG Compound C00937
xref: Reference/PubChem-compound 439350
xref: Reference/CAS 3946-09-6
xref: Reference/ChEBI CHEBI 17167
xref: Reference/ChemSpider 388473
chemical formula: C3H6O2
molecular weight: 74.03678
structure: ChemicalStructure/PW C002750

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Propionyl-CoA carboxylase alpha chain, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q19842
organism: Caenorhabditis elegans

Reference/UniProt Q20780
type: UnificationXref
id: Q20780
db: UniProt

Compound/PW C000936 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine diphosphate
stoichiometric coefficient: 1.0

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Uncharacterized protein
type: Protein
cellular location: Cytoplasm
entity reference: Uncharacterized protein

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

NADPH
type: SmallMolecule
cellular location: Mitochondrion
entity reference: NADPH

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Compound/PW C000101 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Malic acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 749
type: UnificationXref
id: 749
db: ChemSpider

Reference/UniProt Q3S1I8
type: UnificationXref
id: Q3S1I8
db: UniProt

Reference/CAS 71-52-3
type: UnificationXref
id: 71-52-3
db: CAS

Acetyl-CoA acetyltransferase homolog, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q22100
organism: Caenorhabditis elegans

Reference/PubChem-compound 970
type: UnificationXref
id: 970
db: PubChem-compound

Reference/ChemSpider 980
type: UnificationXref
id: 980
db: ChemSpider

Reference/CAS 146-91-8
type: UnificationXref
id: 146-91-8
db: CAS

Compound/PW C000080 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glutathione
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000080
type: ChemicalStructure
structure format: SMILES

L-Malic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000156
xref: Reference/ChEBI CHEBI 30797
xref: Reference/KEGG Compound C00149
xref: Reference/ChemSpider 193317
xref: Reference/PubChem-compound 222656
xref: Reference/CAS 97-67-6
chemical formula: C4H6O5
molecular weight: 134.02153
structure: ChemicalStructure/PW C000101

Hydrogen carbonate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000595
xref: Reference/ChEBI CHEBI 17544
xref: Reference/PubChem-compound 769
xref: Reference/BioCyc HCO3
xref: Reference/ChemSpider 749
xref: Reference/CAS 71-52-3
xref: Reference/KEGG Compound C00288
chemical formula: CHO3
molecular weight: 60.99257
structure: ChemicalStructure/PW C000463

NAD
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NAD

Reference/HMDB HMDB0001175
type: UnificationXref
id: HMDB0001175
db: HMDB

Reference/UniProt Q9U296
type: UnificationXref
id: Q9U296
db: UniProt

Reference/HMDB HMDB0002142
type: UnificationXref
id: HMDB0002142
db: HMDB

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Acetic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15366
xref: Reference/BioCyc ACET
xref: Reference/CAS 64-19-7
xref: Reference/KEGG Compound C00033
xref: Reference/ChemSpider 171
xref: Reference/HMDB HMDB0000042
xref: Reference/PubChem-compound 176
chemical formula: C2H4O2
molecular weight: 60.02113
structure: ChemicalStructure/PW C000029

Oxalacetic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000223
xref: Reference/CAS 328-42-7
xref: Reference/ChEBI CHEBI 30744
xref: Reference/BioCyc OXALACETIC ACID
xref: Reference/ChemSpider 945
xref: Reference/PubChem-compound 970
xref: Reference/KEGG Compound C00036
chemical formula: C4H4O5
molecular weight: 132.00587
structure: ChemicalStructure/PW C000148

Compound/PW C000029 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetic acid
stoichiometric coefficient: 1.0

ChemicalStructure/PW C002986
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)SCCC(S)CCCCC(N)=O

ChemicalStructure/PW C002987
type: ChemicalStructure
structure format: SMILES

Valine, Leucine, and Isoleucine Degradation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway109010
pathway component: SubPathwayInteraction109010
xref: Reference/SMPDB SMP0000032
xref: Reference/PathWhiz PW000051
name: SubPathway

Adenosine monophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine monophosphate

Reference/CAS 64-19-7
type: UnificationXref
id: 64-19-7
db: CAS

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

ChemicalStructure/PW C002750
type: ChemicalStructure
structure format: SMILES
structure data: C[C@@H](O)C=O

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

Reference/ChEBI CHEBI 16928
type: UnificationXref
id: CHEBI:16928
db: ChEBI

Reference/UniProt Q9NAI5
type: UnificationXref
id: Q9NAI5
db: UniProt

Reference/UniProt O44451
type: UnificationXref
id: O44451
db: UniProt

Compound/PW C001142 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetoacetyl-CoA
stoichiometric coefficient: 1.0

Compound/PW C002986 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Acetyldihydrolipoamide-E
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/PubChem-compound 1004
type: UnificationXref
id: 1004
db: PubChem-compound

Reference/PubChem-compound 1005
type: UnificationXref
id: 1005
db: PubChem-compound

Acetyl-CoA acetyltransferase homolog, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Acetyl-CoA acetyltransferase homolog, mitochondrial

D-Lactic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001311
xref: Reference/ChemSpider 55423
xref: Reference/BioCyc D-LACTATE
xref: Reference/CAS 10326-41-7
xref: Reference/KEGG Compound C00256
xref: Reference/PubChem-compound 61503
xref: Reference/ChEBI CHEBI 42111
chemical formula: C3H6O3
molecular weight: 90.03169
structure: ChemicalStructure/PW C001010

Propylene glycol
type: SmallMoleculeReference
xref: Reference/PubChem-compound 1030
xref: Reference/ChemSpider 13835224
xref: Reference/ChEBI CHEBI 16997
xref: Reference/KEGG Compound C00583
xref: Reference/CAS 57-55-6
xref: Reference/BioCyc PROPANE-1,2-DIOL
xref: Reference/HMDB HMDB0001881
chemical formula: C3H8O2
molecular weight: 76.05243
structure: ChemicalStructure/PW C001252

Reference/CAS 328-42-7
type: UnificationXref
id: 328-42-7
db: CAS

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Water
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Water

Glycolysis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway109012
pathway component: SubPathwayInteraction109012
xref: Reference/SMPDB SMP0000040
xref: Reference/PathWhiz PW000146
name: SubPathway

ChemicalStructure/PW C000101
type: ChemicalStructure
structure format: SMILES
structure data: O[C@@H](CC(O)=O)C(O)=O

ChemicalStructure/PW C000463
type: ChemicalStructure
structure format: SMILES
structure data: OC([O-])=O

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Pyruvic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 1060
xref: Reference/HMDB HMDB0000243
xref: Reference/CAS 127-17-3
xref: Reference/BioCyc PYRUVATE
xref: Reference/KEGG Compound C00022
xref: Reference/ChEBI CHEBI 32816
xref: Reference/ChemSpider 1031
chemical formula: C3H4O3
molecular weight: 88.016045
structure: ChemicalStructure/PW C000164

Nicotinate and Nicotinamide Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway109009
pathway component: SubPathwayInteraction109009
xref: Reference/SMPDB SMP0000048
xref: Reference/PathWhiz PW000151
name: SubPathway

1.1.1.27
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000122 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Cytoplasm/Stoichiometry/1.0
right: Pyruvic acid
right: Hydrogen Ion
right: NADH
spontaneous: false
EC number: 1.1.1.27
left: L-Lactic acid
left: NAD
name: L-Lactic acid + NAD ↔ Hydrogen Ion + NADH + Pyruvic acid
conversion direction: REVERSIBLE

4.1.1.32
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000148 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000986 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000936 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000180 Cytoplasm/Stoichiometry/1.0
right: Carbon dioxide
right: Phosphoenolpyruvic acid
right: Guanosine diphosphate
spontaneous: false
EC number: 4.1.1.32
left: Oxalacetic acid
left: Guanosine triphosphate
name: Guanosine triphosphate + Oxalacetic acid ↔ Carbon dioxide + Guanosine diphosphate + Phosphoenolpyruvic acid
conversion direction: REVERSIBLE

Reference/PubChem-compound 1030
type: UnificationXref
id: 1030
db: PubChem-compound

Reaction149036
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000164 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000101 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000101 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Cytoplasm/Stoichiometry/1.0
right: Carbon dioxide
right: Pyruvic acid
right: Hydrogen Ion
right: NADPH
spontaneous: false
left: L-Malic acid
left: NADP
name: L-Malic acid + NADP ↔ Carbon dioxide + Hydrogen Ion + NADPH + Pyruvic acid
conversion direction: REVERSIBLE

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

1.1.2.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000164 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrion/Stoichiometry/2.0
participant stoichiometry: Protein/Generic17 Mitochondrion/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001010 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Protein/Generic16 Mitochondrion/Stoichiometry/2.0
right: Ferrocytochrome c
right: Hydrogen Ion
right: Pyruvic acid
spontaneous: false
EC number: 1.1.2.4
left: Ferricytochrome c
left: D-Lactic acid
name: D-Lactic acid + 2 Ferricytochrome c ↔ 2 Ferrocytochrome c + 2 Hydrogen Ion + Pyruvic acid
conversion direction: REVERSIBLE

3.1.2.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001010 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000841 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000080 Cytoplasm/Stoichiometry/1.0
right: D-Lactic acid
right: Hydrogen Ion
right: Glutathione
spontaneous: false
EC number: 3.1.2.6
left: Water
left: S-Lactoylglutathione
name: S-Lactoylglutathione + Water → D-Lactic acid + Glutathione + Hydrogen Ion
conversion direction: LEFT_TO_RIGHT

4.4.1.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000841 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000905 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000080 Cytoplasm/Stoichiometry/1.0
right: Pyruvaldehyde
right: Glutathione
spontaneous: false
EC number: 4.4.1.5
left: S-Lactoylglutathione
name: S-Lactoylglutathione ↔ Glutathione + Pyruvaldehyde
conversion direction: REVERSIBLE

Reference/ChEBI CHEBI 50623
type: UnificationXref
id: CHEBI:50623
db: ChEBI

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Lactaldehyde
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Lactaldehyde

Compound/PW C001099 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Compound/PW C000101 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Malic acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Hydrogen Ion
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Hydrogen Ion

Reaction149040
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000905 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002750 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytoplasm/Stoichiometry/1.0
right: Hydrogen Ion
right: Pyruvaldehyde
right: NADH
spontaneous: false
left: D-Lactaldehyde
left: NAD
name: D-Lactaldehyde + NAD ↔ Hydrogen Ion + NADH + Pyruvaldehyde
conversion direction: REVERSIBLE

1.1.1.21
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001252 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001765 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytoplasm/Stoichiometry/1.0
right: Hydrogen Ion
right: NADPH
right: Lactaldehyde
spontaneous: false
EC number: 1.1.1.21
left: Propylene glycol
left: NADP
name: NADP + Propylene glycol ← Hydrogen Ion + Lactaldehyde + NADPH
conversion direction: RIGHT_TO_LEFT

Reference/HMDB HMDB0001881
type: UnificationXref
id: HMDB0001881
db: HMDB

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

1.8.1.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000769 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000782 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrion/Stoichiometry/1.0
right: Lipoamide
right: Hydrogen Ion
right: NADH
spontaneous: false
EC number: 1.8.1.4
left: NAD
left: Dihydrolipoamide
name: Dihydrolipoamide + NAD → Hydrogen Ion + Lipoamide + NADH
conversion direction: LEFT_TO_RIGHT

Citric Acid Cycle
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway109011
pathway component: SubPathwayInteraction109011
xref: Reference/PathWhiz PW000005
xref: Reference/SMPDB SMP0000057
name: SubPathway

2.3.1.12
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001099 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000782 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002986 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Cytoplasm/Stoichiometry/1.0
right: Dihydrolipoamide
right: Acetyl-CoA
spontaneous: false
EC number: 2.3.1.12
left: Coenzyme A
left: S-Acetyldihydrolipoamide-E
name: Coenzyme A + S-Acetyldihydrolipoamide-E → Acetyl-CoA + Dihydrolipoamide
conversion direction: LEFT_TO_RIGHT

Reaction149044
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000463 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001441 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000911 Cytoplasm/Stoichiometry/1.0
right: Malonyl-CoA
right: Phosphoric acid
right: Adenosine diphosphate
spontaneous: false
left: Hydrogen carbonate
left: Adenosine triphosphate
left: Acetyl-CoA
name: Acetyl-CoA + Adenosine triphosphate + Hydrogen carbonate → Adenosine diphosphate + Malonyl-CoA + Phosphoric acid
conversion direction: LEFT_TO_RIGHT

Compound/PW C000029 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetic acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 55423
type: UnificationXref
id: 55423
db: ChemSpider

2.3.1.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001142 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Mitochondrion/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001099 Mitochondrion/Stoichiometry/1.0
right: Acetyl-CoA
spontaneous: false
EC number: 2.3.1.9
left: Acetoacetyl-CoA
left: Coenzyme A
name: Acetoacetyl-CoA + Coenzyme A → 2 Acetyl-CoA
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C16255
type: UnificationXref
id: C16255
db: KEGG Compound

3.1.2.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001099 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000029 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Cytoplasm/Stoichiometry/1.0
right: Water
right: Acetyl-CoA
spontaneous: false
EC number: 3.1.2.1
left: Coenzyme A
left: Acetic acid
name: Acetic acid + Coenzyme A ← Acetyl-CoA + Water
conversion direction: RIGHT_TO_LEFT

3.6.1.7
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000029 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001441 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001151 Cytoplasm/Stoichiometry/1.0
right: Acetic acid
right: Phosphoric acid
spontaneous: false
EC number: 3.6.1.7
left: Acetylphosphate
left: Water
name: Acetylphosphate + Water → Acetic acid + Phosphoric acid
conversion direction: LEFT_TO_RIGHT

1.2.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000784 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000029 Mitochondrion/Stoichiometry/1.0
right: Hydrogen Ion
right: Acetic acid
right: NADH
spontaneous: false
EC number: 1.2.1.3
left: Acetaldehyde
left: NAD
left: Water
name: Acetaldehyde + NAD + Water → Acetic acid + Hydrogen Ion + NADH
conversion direction: LEFT_TO_RIGHT

6.2.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000029 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002987 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
right: Acetyl adenylate
right: Pyrophosphate
spontaneous: false
EC number: 6.2.1.1
left: Adenosine triphosphate
left: Acetic acid
name: Acetic acid + Adenosine triphosphate ↔ Acetyl adenylate + Pyrophosphate
conversion direction: REVERSIBLE

ALdehyde deHydrogenase
type: ProteinReference
xref: Reference/UniProt Q20780
organism: Caenorhabditis elegans

Pyrophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyrophosphate

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: O4P
molecular weight: 94.95342
structure: ChemicalStructure/PW C001104

ChemicalStructure/PW C001765
type: ChemicalStructure
structure format: SMILES
structure data: CC(O)C=O

Reference/PubChem-compound 6830
type: UnificationXref
id: 6830
db: PubChem-compound

Compound/PW C001142 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetoacetyl-CoA
stoichiometric coefficient: 1.0

Compound/PW C002987 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl adenylate
stoichiometric coefficient: 1.0

L-Lactic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Lactic acid

Protein/14858 Mitochondrion/Stoichiometry/2.0
type: Stoichiometry
physical entity: Dihydrolipoyl dehydrogenase, mitochondrial
stoichiometric coefficient: 2.0

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

Reference/BioCyc L-LACTATE
type: UnificationXref
id: L-LACTATE
db: BioCyc

Mitochondrion
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005739

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H29N7O17P3
molecular weight: 744.08325
structure: ChemicalStructure/PW C000143

Acetyl-CoA
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Acetyl-CoA
name: SubPathwayInput

6.2.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002987 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000784 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001142 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytosol/Stoichiometry/1.0
right: Acetyl adenylate
right: Adenosine triphosphate
right: Acetaldehyde
spontaneous: false
EC number: 6.2.1.1
left: Adenosine monophosphate
left: Acetoacetyl-CoA
left: Pyrophosphate
name: Acetoacetyl-CoA + Adenosine monophosphate + Pyrophosphate → Acetaldehyde + Acetyl adenylate + Adenosine triphosphate
conversion direction: LEFT_TO_RIGHT

1.2.4.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000164 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000769 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002986 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Mitochondrion/Stoichiometry/1.0
right: Carbon dioxide
right: S-Acetyldihydrolipoamide-E
spontaneous: false
EC number: 1.2.4.1
left: Lipoamide
left: Pyruvic acid
name: Lipoamide + Pyruvic acid → Carbon dioxide + S-Acetyldihydrolipoamide-E
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

SubPathwayInteraction109009
type: Interaction
name: SubPathway109009Reaction
name: SubPathwayReaction
participant: Pyruvic acid

Acetyl-coenzyme A synthetase
type: ProteinReference
xref: Reference/UniProt Q18496
organism: Caenorhabditis elegans

Reference/ChEBI CHEBI 16856
type: UnificationXref
id: CHEBI:16856
db: ChEBI

Dihydrolipoyl dehydrogenase E3
type: Complex
component stoichiometry: Protein/14858 Mitochondrion/Stoichiometry/2.0
cellular location: Mitochondrion
component: Dihydrolipoyl dehydrogenase, mitochondrial

Reference/PubChem-compound 440867
type: UnificationXref
id: 440867
db: PubChem-compound

Reference/PathWhiz PW088468
type: UnificationXref
id: PW088468
db: PathWhiz

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Reference/BioCyc S-LACTOYL-GLUTATHIONE
type: UnificationXref
id: S-LACTOYL-GLUTATHIONE
db: BioCyc

Reference/SMPDB SMP0000040
type: UnificationXref
id: SMP0000040
db: SMPDB

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

Water
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Water

SubPathwayInteraction109010
type: Interaction
name: SubPathwayReaction
name: SubPathway109010Reaction
participant: Pyruvic acid

Malic enzyme
type: Protein
cellular location: Cytoplasm
entity reference: Malic enzyme

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])([O-])=O

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Compound/PW C000146 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Reference/UniProt O45218
type: UnificationXref
id: O45218
db: UniProt

Reference/SMPDB SMP0000048
type: UnificationXref
id: SMP0000048
db: SMPDB

SubPathwayInteraction109015
type: Interaction
name: SubPathway109015Reaction
name: SubPathwayReaction
participant: Acetoacetyl-CoA

SubPathwayInteraction109012
type: Interaction
name: SubPathway109012Reaction
name: SubPathwayReaction
participant: Phosphoenolpyruvic acid

SubPathwayInteraction109011
type: Interaction
name: SubPathwayReaction
name: SubPathway109011Reaction
participant: Oxalacetic acid

SubPathwayInteraction109014
type: Interaction
name: SubPathwayReaction
name: SubPathway109014Reaction
participant: Acetyl-CoA

SubPathwayInteraction109013
type: Interaction
name: SubPathway109013Reaction
name: SubPathwayReaction
participant: Pyruvaldehyde

Reference/ChEBI CHEBI 15531
type: UnificationXref
id: CHEBI:15531
db: ChEBI

Probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

Compound/PW C002987 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl adenylate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/BioCyc DIHYDROLIPOAMIDE
type: UnificationXref
id: DIHYDROLIPOAMIDE
db: BioCyc

Reference/ChEBI CHEBI 37666
type: UnificationXref
id: CHEBI:37666
db: ChEBI

ALdehyde deHydrogenase
type: Protein
cellular location: Mitochondrion
entity reference: ALdehyde deHydrogenase

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0001311
type: UnificationXref
id: HMDB0001311
db: HMDB

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Compound/PW C040034 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Lipoamide
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Lipoamide

Reference/HMDB HMDB0000223
type: UnificationXref
id: HMDB0000223
db: HMDB

Glutathione
type: SmallMoleculeReference
xref: Reference/CAS 70-18-8
xref: Reference/HMDB HMDB0000125
xref: Reference/BioCyc OXIDIZED-GLUTATHIONE
xref: Reference/KEGG Compound C00051
xref: Reference/ChEBI CHEBI 16856
xref: Reference/PubChem-compound 124886
xref: Reference/ChemSpider 111188
chemical formula: C10H17N3O6S
molecular weight: 307.0838
structure: ChemicalStructure/PW C000080

Protein/16154 Cytoplasm/Stoichiometry/4.0
type: Stoichiometry
physical entity: Pyruvate kinase
stoichiometric coefficient: 4.0

Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
type: UnificationXref
id: GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
db: BioCyc

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Acetoacetyl-CoA
type: SmallMolecule
cellular location: Cytosol
entity reference: Acetoacetyl-CoA

Reference/BioCyc PROPANE-1,2-DIOL
type: UnificationXref
id: PROPANE-1,2-DIOL
db: BioCyc

Reference/SMPDB SMP0000057
type: UnificationXref
id: SMP0000057
db: SMPDB

Glycine and Serine Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway109013
pathway component: SubPathwayInteraction109013
xref: Reference/PathWhiz PW000157
xref: Reference/SMPDB SMP0000004
name: SubPathway

Reference/UniProt Q19749
type: UnificationXref
id: Q19749
db: UniProt

Reference/SMPDB SMP0087449
type: UnificationXref
id: SMP0087449
db: SMPDB

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Compound/PW C001252 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Propylene glycol
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00937
type: UnificationXref
id: C00937
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Pyruvate carboxylase 1
type: Protein
cellular location: Cytoplasm
entity reference: Pyruvate carboxylase 1

Reference/HMDB HMDB0001201
type: UnificationXref
id: HMDB0001201
db: HMDB

ChemicalStructure/PW C001441
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/HMDB HMDB0000595
type: UnificationXref
id: HMDB0000595
db: HMDB

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: O7P2
molecular weight: 173.91193
structure: ChemicalStructure/PW C000170

Acetoacetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETOACETYL-COA
xref: Reference/PubChem-compound 439214
xref: Reference/ChEBI CHEBI 15345
xref: Reference/CAS 1420-36-6
xref: Reference/HMDB HMDB0001484
xref: Reference/KEGG Compound C00332
xref: Reference/ChemSpider 388353
chemical formula: C25H40N7O18P3S
molecular weight: 851.13635
structure: ChemicalStructure/PW C001142

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Compound/PW C000905 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvaldehyde
stoichiometric coefficient: 1.0

Acetoacetyl-CoA
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Acetoacetyl-CoA
name: SubPathwayInput

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

Propanoate Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway109014
pathway component: SubPathwayInteraction109014
xref: Reference/PathWhiz PW000149
xref: Reference/SMPDB SMP0000016
name: SubPathway

Compound/PW C000180 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoenolpyruvic acid
stoichiometric coefficient: 1.0

Compound/PW C000122 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Lactic acid
stoichiometric coefficient: 1.0

Reference/UniProt Q19842
type: UnificationXref
id: Q19842
db: UniProt

Reference/ChEBI CHEBI 15996
type: UnificationXref
id: CHEBI:15996
db: ChEBI

Malonyl-CoA
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Malonyl-CoA

Reference/ChEBI CHEBI 15991
type: UnificationXref
id: CHEBI:15991
db: ChEBI

Compound/PW C040034 Mitochondrion/Stoichiometry/2.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 2.0

Acetylphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00227
xref: Reference/CAS 590-54-5
xref: Reference/BioCyc ACETYL-P
xref: Reference/HMDB HMDB0001494
xref: Reference/ChemSpider 181
xref: Reference/ChEBI CHEBI 15350
xref: Reference/PubChem-compound 186
chemical formula: C2H5O5P
molecular weight: 139.98746
structure: ChemicalStructure/PW C001151

Reference/HMDB HMDB0000243
type: UnificationXref
id: HMDB0000243
db: HMDB

Compound/PW C001144 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Phosphoenolpyruvic acid
type: SmallMoleculeReference
xref: Reference/CAS 138-08-9
xref: Reference/ChEBI CHEBI 44897
xref: Reference/KEGG Compound C00074
xref: Reference/BioCyc PHOSPHO-ENOL-PYRUVATE
xref: Reference/ChemSpider 980
xref: Reference/PubChem-compound 1005
xref: Reference/HMDB HMDB0000263
chemical formula: C3H5O6P
molecular weight: 167.98238
structure: ChemicalStructure/PW C000180

Reference/HMDB HMDB0000125
type: UnificationXref
id: HMDB0000125
db: HMDB

Reference/GENE ONTOLOGY GO 0005739
type: UnificationXref
id: GO:0005739
db: GENE ONTOLOGY

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Reference/SMPDB SMP0000071
type: UnificationXref
id: SMP0000071
db: SMPDB

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/BioCyc ACETYL AMP
type: UnificationXref
id: ACETYL_AMP
db: BioCyc

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

ChemicalStructure/PW C000122
type: ChemicalStructure
structure format: SMILES
structure data: C[C@@H](O)C(O)=O

Coenzyme A
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Coenzyme A

Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/CAS 70-18-8
type: UnificationXref
id: 70-18-8
db: CAS

Acetyl adenylate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Acetyl adenylate

Compound/PW C000841 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Lactoylglutathione
stoichiometric coefficient: 1.0

NADH
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NADH

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Alkyldihydroxyacetonephosphate synthase
type: Protein
cellular location: Mitochondrion
entity reference: Alkyldihydroxyacetonephosphate synthase

ChemicalStructure/PW C000841
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/BioCyc METHYL-GLYOXAL
type: UnificationXref
id: METHYL-GLYOXAL
db: BioCyc

Reference/BioCyc ACETYL-P
type: UnificationXref
id: ACETYL-P
db: BioCyc

Reference/SMPDB SMP0000004
type: UnificationXref
id: SMP0000004
db: SMPDB

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Reference/SMPDB SMP0000016
type: UnificationXref
id: SMP0000016
db: SMPDB

Reference/PubChem-compound 222656
type: UnificationXref
id: 222656
db: PubChem-compound

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

Acetic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Acetic acid

Pyruvate kinase
type: Protein
cellular location: Cytoplasm
entity reference: Pyruvate kinase

Reference/ChEBI CHEBI 15694
type: UnificationXref
id: CHEBI:15694
db: ChEBI

Carbon dioxide
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Carbon dioxide

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Caenorhabditis elegans
type: BioSource
xref: Reference/TAXONOMY 6239

Propionyl-CoA carboxylase alpha chain, mitochondrial
type: Protein
cellular location: Cytoplasm
entity reference: Propionyl-CoA carboxylase alpha chain, mitochondrial

Protein/14850 Mitochondrion/Stoichiometry/2.0
type: Stoichiometry
physical entity: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
stoichiometric coefficient: 2.0

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Malate dehydrogenase
type: Protein
cellular location: Cytoplasm
entity reference: Malate dehydrogenase

Propylene glycol
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Propylene glycol

Compound/PW C000032 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

Compound/PW C000940 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

NADPH
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NADPH

Reference/ChemSpider 10213
type: UnificationXref
id: 10213
db: ChemSpider

Reference/BioCyc ACETOACETYL-COA
type: UnificationXref
id: ACETOACETYL-COA
db: BioCyc

Reference/TAXONOMY 6239
type: UnificationXref
id: 6239
db: TAXONOMY

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Coenzyme A
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Coenzyme A

Reference/ChEBI CHEBI 16997
type: UnificationXref
id: CHEBI:16997
db: ChEBI

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

Oxalacetic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Oxalacetic acid
name: SubPathwayInput

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

Reference/CAS 524-14-1
type: UnificationXref
id: 524-14-1
db: CAS

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Compound/PW C001441 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoric acid
stoichiometric coefficient: 1.0

Guanosine diphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Guanosine diphosphate

Reference/CAS 79-33-4
type: UnificationXref
id: 79-33-4
db: CAS

Hydrogen Ion
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Hydrogen Ion

Reference/CAS 127-17-3
type: UnificationXref
id: 127-17-3
db: CAS

Reference/ChemSpider 13835224
type: UnificationXref
id: 13835224
db: ChemSpider

Reference/PubChem-compound 439214
type: UnificationXref
id: 439214
db: PubChem-compound

S-Acetyldihydrolipoamide-E
type: SmallMolecule
cellular location: Cytoplasm
entity reference: S-Acetyldihydrolipoamide-E

Reference/UniProt D3YT81
type: UnificationXref
id: D3YT81
db: UniProt

Protein/Generic16 Mitochondrion/Stoichiometry/2.0
type: Stoichiometry
physical entity: Ferrocytochrome c
stoichiometric coefficient: 2.0

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Reference/ChemSpider 389032
type: UnificationXref
id: 389032
db: ChemSpider

Reference/PubChem-compound 8977
type: UnificationXref
id: 8977
db: PubChem-compound

Phosphoric acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphoric acid

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Compound/PW C002986 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Acetyldihydrolipoamide-E
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000962
type: UnificationXref
id: HMDB0000962
db: HMDB

D-Lactaldehyde
type: SmallMolecule
cellular location: Cytoplasm
entity reference: D-Lactaldehyde

Reference/SMPDB SMP0000032
type: UnificationXref
id: SMP0000032
db: SMPDB

NADH
type: SmallMolecule
cellular location: Mitochondrion
entity reference: NADH

Reference/ChEBI CHEBI 15366
type: UnificationXref
id: CHEBI:15366
db: ChEBI

ReactionCatalysis139435
type: Catalysis
controller: Acetyl-CoA acetyltransferase, mitochondrial
controlled: 2.3.1.9
control type: ACTIVATION

ReactionCatalysis139438
type: Catalysis
controller: Unknown
controlled: 3.6.1.7
control type: ACTIVATION

Reference/ChEBI CHEBI 17544
type: UnificationXref
id: CHEBI:17544
db: ChEBI

ReactionCatalysis139437
type: Catalysis
controller: Unknown
controlled: 3.1.2.1
control type: ACTIVATION

ReactionCatalysis139432
type: Catalysis
controller: Dihydrolipoyl dehydrogenase E3
controlled: 1.8.1.4
control type: ACTIVATION

Reference/PathWhiz PW000149
type: UnificationXref
id: PW000149
db: PathWhiz

Reference/PathWhiz PW000028
type: UnificationXref
id: PW000028
db: PathWhiz

ReactionCatalysis139431
type: Catalysis
controller: Uncharacterized protein
controlled: 1.1.1.21
control type: ACTIVATION

ReactionCatalysis139434
type: Catalysis
controller: Propionyl-CoA carboxylase alpha chain, mitochondrial
controlled: Reaction149044
control type: ACTIVATION

ReactionCatalysis139433
type: Catalysis
controller: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
controlled: 2.3.1.12
control type: ACTIVATION

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

Reference/PathWhiz PW000146
type: UnificationXref
id: PW000146
db: PathWhiz

Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 8630
type: UnificationXref
id: 8630
db: ChemSpider

Pyruvaldehyde
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001167
xref: Reference/KEGG Compound C00546
xref: Reference/ChEBI CHEBI 17158
xref: Reference/CAS 78-98-8
xref: Reference/BioCyc METHYL-GLYOXAL
xref: Reference/ChemSpider 857
xref: Reference/PubChem-compound 880
chemical formula: C3H4O2
molecular weight: 72.021126
structure: ChemicalStructure/PW C000905

ReactionCatalysis139439
type: Catalysis
controller: Aldehyde dehydrogenase, mitochondrial
controlled: 1.2.1.3
control type: ACTIVATION

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

ChemicalStructure/PW C000769
type: ChemicalStructure
structure format: SMILES
structure data: NC(=O)CCCCC1CCSS1

Compound/PW C000911 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Malonyl-CoA
stoichiometric coefficient: 1.0

Acetyl-coenzyme A synthetase
type: Protein
cellular location: Cytoplasm
entity reference: Acetyl-coenzyme A synthetase

Pyruvate carboxylase, mitochondrial
type: Complex
component stoichiometry: Protein/14907 Cytoplasm/Stoichiometry/4.0
cellular location: Cytoplasm
component: Pyruvate carboxylase 1

Reference/PubChem-compound 439231
type: UnificationXref
id: 439231
db: PubChem-compound

Reference/CAS 75-07-0
type: UnificationXref
id: 75-07-0
db: CAS

ReactionCatalysis139430
type: Catalysis
controller: Uncharacterized protein
controlled: Reaction149040
control type: ACTIVATION

Reference/ChemSpider 172
type: UnificationXref
id: 172
db: ChemSpider

Reference/ChemSpider 171
type: UnificationXref
id: 171
db: ChemSpider

Reference/ChEBI CHEBI 32816
type: UnificationXref
id: CHEBI:32816
db: ChEBI

Compound/PW C000146 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Reference/CAS 1420-36-6
type: UnificationXref
id: 1420-36-6
db: CAS

Protein/15162 Mitochondrion/Stoichiometry/4.0
type: Stoichiometry
physical entity: Acetyl-CoA acetyltransferase homolog, mitochondrial
stoichiometric coefficient: 4.0

Probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial
type: ProteinReference
xref: Reference/UniProt P52899
organism: Caenorhabditis elegans

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q19749
organism: Caenorhabditis elegans

Malonyl-CoA
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15531
xref: Reference/KEGG Compound C00083
xref: Reference/BioCyc MALONYL-COA
xref: Reference/CAS 524-14-1
xref: Reference/HMDB HMDB0001175
xref: Reference/PubChem-compound 10663
xref: Reference/ChemSpider 10213
chemical formula: C24H38N7O19P3S
molecular weight: 853.1156
structure: ChemicalStructure/PW C000911

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
type: ProteinReference
xref: Reference/UniProt O44451
organism: Caenorhabditis elegans

ReactionCatalysis139443
type: Catalysis
controller: Pyruvate dehydrogenase E1
controlled: 1.2.4.1
control type: ACTIVATION

ReactionCatalysis139442
type: Catalysis
controller: Acetyl-coenzyme A synthetase
controlled: 6.2.1.1
control type: ACTIVATION

Reference/ChemSpider 6569
type: UnificationXref
id: 6569
db: ChemSpider

Reference/BioCyc ACETALD
type: UnificationXref
id: ACETALD
db: BioCyc

Acetaldehyde
type: SmallMolecule
cellular location: Cytosol
entity reference: Acetaldehyde

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
type: Protein
cellular location: Cytoplasm
entity reference: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Reference/PubChem-compound 439350
type: UnificationXref
id: 439350
db: PubChem-compound

L-Malic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: L-Malic acid

Reference/ChEBI CHEBI 17552
type: UnificationXref
id: CHEBI:17552
db: ChEBI

Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphate

Reaction148815
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000148 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000101 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytoplasm/Stoichiometry/1.0
right: Hydrogen Ion
right: NADH
right: Oxalacetic acid
spontaneous: false
left: NAD
left: L-Malic acid
name: L-Malic acid + NAD ↔ Hydrogen Ion + NADH + Oxalacetic acid
conversion direction: REVERSIBLE

6.4.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000463 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000148 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
right: Oxalacetic acid
right: Adenosine diphosphate
right: Phosphate
spontaneous: false
EC number: 6.4.1.1
left: Pyruvic acid
left: Hydrogen carbonate
left: Adenosine triphosphate
name: Adenosine triphosphate + Hydrogen carbonate + Pyruvic acid → Adenosine diphosphate + Oxalacetic acid + Phosphate
conversion direction: LEFT_TO_RIGHT

Lactoylglutathione lyase
type: Complex
component stoichiometry: Protein/10857 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Unknown

Compound/PW C000769 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lipoamide
stoichiometric coefficient: 1.0

Acetyl-coenzyme A synthetase
type: Protein
cellular location: Cytosol
entity reference: Acetyl-coenzyme A synthetase

Reference/ChEBI CHEBI 422
type: UnificationXref
id: CHEBI:422
db: ChEBI

Reference/HMDB HMDB0000985
type: UnificationXref
id: HMDB0000985
db: HMDB

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

ChemicalStructure/PW C000784
type: ChemicalStructure
structure format: SMILES
structure data: CC=O

Reference/ChEBI CHEBI 30744
type: UnificationXref
id: CHEBI:30744
db: ChEBI

ChemicalStructure/PW C000782
type: ChemicalStructure
structure format: SMILES
structure data: OC(=N)CCCCC(S)CCS

ReactionCatalysis139441
type: Catalysis
controller: Acetyl-coenzyme A synthetase
controlled: 6.2.1.1
control type: ACTIVATION

Reference/ChemSpider 111188
type: UnificationXref
id: 111188
db: ChemSpider

Dihydrolipoyl dehydrogenase, mitochondrial
type: ProteinReference
xref: Reference/UniProt D3YT81
organism: Caenorhabditis elegans

Reference/PubChem-compound 61503
type: UnificationXref
id: 61503
db: PubChem-compound

Reference/ChEBI CHEBI 15343
type: UnificationXref
id: CHEBI:15343
db: ChEBI

Reference/ChEBI CHEBI 15345
type: UnificationXref
id: CHEBI:15345
db: ChEBI

Reference/PathWhiz PW000005
type: UnificationXref
id: PW000005
db: PathWhiz

ChemicalStructure/PW C000986
type: ChemicalStructure
structure format: SMILES

Acetic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Acetic acid

Reference/PubChem-compound 186
type: UnificationXref
id: 186
db: PubChem-compound

Reference/ChemSpider 193317
type: UnificationXref
id: 193317
db: ChemSpider

Reference/CAS 86-01-1
type: UnificationXref
id: 86-01-1
db: CAS

Compound/PW C001151 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetylphosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000990
type: UnificationXref
id: HMDB0000990
db: HMDB

Reference/PubChem-compound 1060
type: UnificationXref
id: 1060
db: PubChem-compound

ReactionCatalysis139425
type: Catalysis
controller: Phosphoenolypyruvate CarboxyKinase
controlled: 4.1.1.32
control type: ACTIVATION

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

ReactionCatalysis139424
type: Catalysis
controller: Unknown
controlled: 1.1.1.27
control type: ACTIVATION

ReactionCatalysis139427
type: Catalysis
controller: Alkyldihydroxyacetonephosphate synthase
controlled: 1.1.2.4
control type: ACTIVATION

Reference/KEGG Compound C00546
type: UnificationXref
id: C00546
db: KEGG Compound

Reference/KEGG Compound C00424
type: UnificationXref
id: C00424
db: KEGG Compound

ReactionCatalysis139426
type: Catalysis
controller: NADP-dependent malic enzyme
controlled: Reaction149036
control type: ACTIVATION

Compound/PW C001010 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Lactic acid
stoichiometric coefficient: 1.0

Protein/16352 Cytoplasm/Stoichiometry/4.0
type: Stoichiometry
physical entity: Malic enzyme
stoichiometric coefficient: 4.0

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

ReactionCatalysis139429
type: Catalysis
controller: Lactoylglutathione lyase
controlled: 4.4.1.5
control type: ACTIVATION

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

Reference/PubChem-compound 177
type: UnificationXref
id: 177
db: PubChem-compound

ReactionCatalysis139428
type: Catalysis
controller: Uncharacterized protein
controlled: 3.1.2.6
control type: ACTIVATION

Reference/ChEBI CHEBI 15350
type: UnificationXref
id: CHEBI:15350
db: ChEBI

Reference/PubChem-compound 176
type: UnificationXref
id: 176
db: PubChem-compound

Reference/PubChem-compound 24906332
type: UnificationXref
id: 24906332
db: PubChem-compound

Reference/CAS 3884-47-7
type: UnificationXref
id: 3884-47-7
db: CAS

Compound/PW C000721 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

Uncharacterized protein
type: ProteinReference
xref: Reference/UniProt Q9NAI5
organism: Caenorhabditis elegans

Dihydrolipoamide
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Dihydrolipoamide

Reference/BioCyc MALONYL-COA
type: UnificationXref
id: MALONYL-COA
db: BioCyc

Reference/ChemSpider 181
type: UnificationXref
id: 181
db: ChemSpider