ReactionCatalysis139755
type: Catalysis
controller: Uncharacterized protein
controlled: Reaction149359
control type: ACTIVATION

ReactionCatalysis139754
type: Catalysis
controller: Uncharacterized protein
controlled: 1.1.1.21
control type: ACTIVATION

ReactionCatalysis139757
type: Catalysis
controller: L-xylulose reductase
controlled: 1.1.1.153
control type: ACTIVATION

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

ReactionCatalysis139751
type: Catalysis
controller: Putative 6-pyruvoyl tetrahydrobiopterin synthase
controlled: 4.2.3.12
control type: ACTIVATION

ReactionCatalysis139750
type: Catalysis
controller: GTP cyclohydrolase
controlled: 3.5.4.16
control type: ACTIVATION

ReactionCatalysis139753
type: Catalysis
controller: L-xylulose reductase
controlled: 1.1.1.153
control type: ACTIVATION

Dihydrobiopterin
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 64277
xref: Reference/ChemSpider 247
xref: Reference/HMDB HMDB0000038
xref: Reference/KEGG Compound C02953
xref: Reference/BioCyc BIOPTERIN
xref: Reference/CAS 6779-87-9
xref: Reference/PubChem-compound 252
chemical formula: C9H13N5O3
molecular weight: 239.10184
structure: ChemicalStructure/PW C000027

ReactionCatalysis139752
type: Catalysis
controller: L-xylulose reductase
controlled: 1.1.1.153
control type: ACTIVATION

Reference/ChemSpider 389682
type: UnificationXref
id: 389682
db: ChemSpider

ChemicalStructure/PW C001537
type: ChemicalStructure
structure format: SMILES
structure data: NC1=NC(=O)C2=C(NCC(=N2)C(O)C(O)CO)N1

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

ReactionCatalysis139759
type: Catalysis
controller: L-xylulose reductase
controlled: 1.1.1.153
control type: ACTIVATION

ReactionCatalysis139758
type: Catalysis
controller: Uncharacterized protein
controlled: Reaction149362
control type: ACTIVATION

Reference/ChemSpider 389683
type: UnificationXref
id: 389683
db: ChemSpider

Dihydrofolate reductase
type: Complex
component stoichiometry: Protein/10857 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Unknown

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Dihydropteridine reductase
type: Complex
component stoichiometry: Protein/17258 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Quinoid DihydroPteridine Reductase

SubPathwayInteraction109058
type: Interaction
name: SubPathway109058Reaction
name: SubPathwayReaction
participant: Guanosine triphosphate

Reference/UniProt Q9NAI5
type: UnificationXref
id: Q9NAI5
db: UniProt

Reference/HMDB HMDB0002275
type: UnificationXref
id: HMDB0002275
db: HMDB

Compound/PW C000019 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tetrahydrobiopterin
stoichiometric coefficient: 1.0

Pterine Biosynthesis
type: Pathway
pathway order: PathwayEnzymeReaction/2116985
pathway order: PathwayEnzymeReaction/2116996
pathway order: PathwayEnzymeReaction/2116986
pathway order: PathwayEnzymeReaction/2116997
pathway order: PathwayEnzymeReaction/2116987
pathway order: PathwayEnzymeReaction/2116998
pathway order: PathwayEnzymeReaction/2116988
pathway order: PathwayEnzymeReaction/2116999
pathway order: PathwaySubPathway/109058
pathway order: PathwayEnzymeReaction/2116992
pathway order: PathwayEnzymeReaction/2116993
pathway order: PathwayEnzymeReaction/2116994
pathway order: PathwayEnzymeReaction/2116984
pathway order: PathwayEnzymeReaction/2116995
pathway order: PathwayEnzymeReaction/2116989
pathway order: PathwayEnzymeReaction/2117000
pathway order: PathwayEnzymeReaction/2116990
pathway order: PathwayEnzymeReaction/2116991
pathway component: 3.5.4.16
pathway component: ReactionCatalysis139755
pathway component: ReactionCatalysis139754
pathway component: ReactionCatalysis139757
pathway component: 4.2.3.12
pathway component: ReactionCatalysis139751
pathway component: ReactionCatalysis139750
pathway component: 1.1.1.153
pathway component: ReactionCatalysis139753
pathway component: ReactionCatalysis139752
pathway component: 1.1.1.21
pathway component: Reaction149359
pathway component: ReactionCatalysis139759
pathway component: ReactionCatalysis139758
pathway component: Reaction1111
pathway component: Purine Metabolism
pathway component: Reaction149362
pathway component: 1.5.1.3
pathway component: 1.5.1.34
pathway component: ReactionCatalysis139762
pathway component: ReactionCatalysis139761
pathway component: ReactionCatalysis139748
pathway component: ReactionCatalysis139747
pathway component: ReactionCatalysis139749
pathway component: Reaction1105
pathway component: ReactionCatalysis139760
xref: Reference/PathWhiz PW088505
xref: Reference/SMPDB SMP0087486
organism: Caenorhabditis elegans

ReactionCatalysis139762
type: Catalysis
controller: L-xylulose reductase
controlled: 1.1.1.153
control type: ACTIVATION

ReactionCatalysis139761
type: Catalysis
controller: Dihydropteridine reductase
controlled: 1.5.1.34
control type: ACTIVATION

Uncharacterized protein
type: Protein
cellular location: Cytosol
entity reference: Uncharacterized protein

Reference/PubChem-compound 1125
type: UnificationXref
id: 1125
db: PubChem-compound

Compound/PW C000143 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Reference/KEGG Compound C04244
type: UnificationXref
id: C04244
db: KEGG Compound

Reference/PathWhiz PW000052
type: UnificationXref
id: PW000052
db: PathWhiz

Reference/ChEBI CHEBI 58104
type: UnificationXref
id: CHEBI:58104
db: ChEBI

Sepiapterin
type: SmallMoleculeReference
xref: Reference/ChemSpider 58746
xref: Reference/HMDB HMDB0000238
xref: Reference/KEGG Compound C00835
xref: Reference/BioCyc CPD-374
xref: Reference/PubChem-compound 65253
xref: Reference/CAS 17094-01-8
xref: Reference/ChEBI CHEBI 804632
chemical formula: C9H11N5O3
molecular weight: 237.08618
structure: ChemicalStructure/PW C000160

Reference/ChemSpider 247
type: UnificationXref
id: 247
db: ChemSpider

Reference/CAS 20574-65-6
type: UnificationXref
id: 20574-65-6
db: CAS

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/HMDB HMDB0001195
type: UnificationXref
id: HMDB0001195
db: HMDB

ReactionCatalysis139760
type: Catalysis
controller: Dihydrofolate reductase
controlled: 1.5.1.3
control type: ACTIVATION

L-xylulose reductase
type: Protein
cellular location: Cytosol
entity reference: L-xylulose reductase

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

1-hydroxy-2-Oxopropyl tetrahydropterin
type: SmallMolecule
cellular location: Cytosol
entity reference: 1-hydroxy-2-Oxopropyl tetrahydropterin

6-Lactoyltetrahydropterin
type: SmallMolecule
cellular location: Cytosol
entity reference: 6-Lactoyltetrahydropterin

Reference/PubChem-compound 65253
type: UnificationXref
id: 65253
db: PubChem-compound

Reference/ChemSpider 958
type: UnificationXref
id: 958
db: ChemSpider

NADH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADH

2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
type: SmallMolecule
cellular location: Cytosol
entity reference: 2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine

Reference/PubChem-compound 440841
type: UnificationXref
id: 440841
db: PubChem-compound

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/PubChem-compound 440840
type: UnificationXref
id: 440840
db: PubChem-compound

Compound/PW C000092 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Formic acid
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/ChemSpider 278
type: UnificationXref
id: 278
db: ChemSpider

ChemicalStructure/PW C000673
type: ChemicalStructure
structure format: SMILES
structure data: NC1=NC2=C(N=C(C=N2)C(O)C(O)CO)C(=O)N1

Purine Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway109058
pathway component: SubPathwayInteraction109058
xref: Reference/SMPDB SMP0000050
xref: Reference/PathWhiz PW000052
name: SubPathway

Reference/BioCyc 6-LACTOYL-5678-TETRAHYDROPTERIN
type: UnificationXref
id: 6-LACTOYL-5678-TETRAHYDROPTERIN
db: BioCyc

Reference/CAS 2009-64-5
type: UnificationXref
id: 2009-64-5
db: CAS

Guanosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Guanosine triphosphate
name: SubPathwayOutput

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Protein/17258 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Quinoid DihydroPteridine Reductase
stoichiometric coefficient: 2.0

Tetrahydrobiopterin
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00272
xref: Reference/HMDB HMDB0000027
xref: Reference/CAS 17528-72-2
xref: Reference/BioCyc TETRA-H-BIOPTERIN
xref: Reference/PubChem-compound 1125
xref: Reference/ChemSpider 1093
xref: Reference/ChEBI CHEBI 15372
chemical formula: C9H15N5O3
molecular weight: 241.1175
structure: ChemicalStructure/PW C000019

Compound/PW C000027 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydrobiopterin
stoichiometric coefficient: 1.0

Reference/PubChem-compound 13846017
type: UnificationXref
id: 13846017
db: PubChem-compound

Dyspropterin
type: SmallMoleculeReference
xref: Reference/PubChem-compound 128973
xref: Reference/ChemSpider 114280
xref: Reference/CAS 89687-39-8
xref: Reference/BioCyc 6-PYRUVOYL-5678-TETRAHYDROPTERIN
xref: Reference/HMDB HMDB0001195
xref: Reference/ChEBI CHEBI 17804
xref: Reference/KEGG Compound C03684
chemical formula: C9H11N5O3
molecular weight: 237.08618
structure: ChemicalStructure/PW C000930

Compound/PW C002950 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2,5-Diaminopyrimidine nucleoside triphosphate
stoichiometric coefficient: 1.0

ReactionCatalysis139748
type: Catalysis
controller: GTP cyclohydrolase
controlled: 3.5.4.16
control type: ACTIVATION

Reference/PubChem-compound 6830
type: UnificationXref
id: 6830
db: PubChem-compound

ReactionCatalysis139747
type: Catalysis
controller: GTP cyclohydrolase
controlled: 3.5.4.16
control type: ACTIVATION

Reference/BioCyc DIHYDRONEOPTERIN-P3
type: UnificationXref
id: DIHYDRONEOPTERIN-P3
db: BioCyc

Reference/PubChem-compound 252
type: UnificationXref
id: 252
db: PubChem-compound

ReactionCatalysis139749
type: Catalysis
controller: GTP cyclohydrolase
controlled: 3.5.4.16
control type: ACTIVATION

Reference/UniProt Q2MGF4
type: UnificationXref
id: Q2MGF4
db: UniProt

Reference/PubChem-compound 169508
type: UnificationXref
id: 169508
db: PubChem-compound

Uncharacterized protein
type: Protein
cellular location: Cytosol
entity reference: Uncharacterized protein

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H29N7O17P3
molecular weight: 744.08325
structure: ChemicalStructure/PW C000143

Reference/HMDB HMDB0002065
type: UnificationXref
id: HMDB0002065
db: HMDB

Reference/ChEBI CHEBI 929
type: UnificationXref
id: CHEBI:929
db: ChEBI

Reference/HMDB HMDB0013642
type: UnificationXref
id: HMDB0013642
db: HMDB

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Guanosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15996
xref: Reference/ChemSpider 6569
xref: Reference/KEGG Compound C00044
xref: Reference/PubChem-compound 6830
xref: Reference/HMDB HMDB0001273
xref: Reference/CAS 86-01-1
xref: Reference/BioCyc GTP
chemical formula: C10H16N5O14P3
molecular weight: 522.99066
structure: ChemicalStructure/PW C000986

Compound/PW C000146 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Reference/KEGG Compound C05926
type: UnificationXref
id: C05926
db: KEGG Compound

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/KEGG Compound C05923
type: UnificationXref
id: C05923
db: KEGG Compound

Reference/KEGG Compound C05922
type: UnificationXref
id: C05922
db: KEGG Compound

Uncharacterized protein
type: ProteinReference
xref: Reference/UniProt Q93544
organism: Caenorhabditis elegans

Protein/10857 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 2.0

Reference/ChemSpider 148245
type: UnificationXref
id: 148245
db: ChemSpider

Compound/PW C001144 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

PPPi
type: SmallMoleculeReference
xref: Reference/BioCyc P3I
xref: Reference/KEGG Compound C00404
xref: Reference/PubChem-compound 983
xref: Reference/ChEBI CHEBI 39949
xref: Reference/CAS 10380-08-2
xref: Reference/HMDB HMDB0012282
xref: Reference/ChemSpider 958
chemical formula: H5O10P3
molecular weight: 257.90955
structure: ChemicalStructure/PW C007822

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Reference/CAS 33405-80-0
type: UnificationXref
id: 33405-80-0
db: CAS

Protein/17243 Cytosol/Stoichiometry/10.0
type: Stoichiometry
physical entity: GTP cyclohydrolase I Feedback Regulatory Protein homolog
stoichiometric coefficient: 10.0

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

GTP cyclohydrolase I Feedback Regulatory Protein homolog
type: Protein
cellular location: Cytosol
entity reference: GTP cyclohydrolase I Feedback Regulatory Protein homolog

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

ChemicalStructure/PW C000019
type: ChemicalStructure
structure format: SMILES
structure data: CC(O)C(O)C1CNC2=C(N1)C(=O)N=C(N)N2

Compound/PW C007822 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: PPPi
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000930
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)C(=O)C1CNC2=C(N1)C(=O)NC(N)=N2

Compound/PW C000721 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/ChemSpider 4300
type: UnificationXref
id: 4300
db: ChemSpider

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

NADPH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADPH

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/SMPDB SMP0000050
type: UnificationXref
id: SMP0000050
db: SMPDB

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Dihydroneopterin triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Dihydroneopterin triphosphate

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/UniProt Q19980
type: UnificationXref
id: Q19980
db: UniProt

Reference/ChemSpider 108735
type: UnificationXref
id: 108735
db: ChemSpider

Tetrahydrobiopterin
type: SmallMolecule
cellular location: Cytosol
entity reference: Tetrahydrobiopterin

GTP cyclohydrolase 1
type: Protein
cellular location: Cytosol
entity reference: GTP cyclohydrolase 1

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Reference/ChEBI CHEBI 17248
type: UnificationXref
id: CHEBI:17248
db: ChEBI

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H28N7O14P2
molecular weight: 664.11694
structure: ChemicalStructure/PW C000721

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Reference/ChEBI CHEBI 804632
type: UnificationXref
id: CHEBI:804632
db: ChEBI

Reference/ChEBI CHEBI 17001
type: UnificationXref
id: CHEBI:17001
db: ChEBI

Reference/CAS 89687-39-8
type: UnificationXref
id: 89687-39-8
db: CAS

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reference/ChEBI CHEBI 39949
type: UnificationXref
id: CHEBI:39949
db: ChEBI

6-Lactoyltetrahydropterin
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17248
xref: Reference/PubChem-compound 169508
xref: Reference/BioCyc 6-LACTOYL-5678-TETRAHYDROPTERIN
xref: Reference/CAS 33405-80-0
xref: Reference/KEGG Compound C04244
xref: Reference/ChemSpider 148245
xref: Reference/HMDB HMDB0002065
chemical formula: C9H13N5O3
molecular weight: 239.10184
structure: ChemicalStructure/PW C001388

Reference/HMDB HMDB0000238
type: UnificationXref
id: HMDB0000238
db: HMDB

Quinoid DihydroPteridine Reductase
type: Protein
cellular location: Cytosol
entity reference: Quinoid DihydroPteridine Reductase

Reference/ChemSpider 114280
type: UnificationXref
id: 114280
db: ChemSpider

Reference/ChemSpider 389753
type: UnificationXref
id: 389753
db: ChemSpider

Reference/ChEBI CHEBI 15996
type: UnificationXref
id: CHEBI:15996
db: ChEBI

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

ChemicalStructure/PW C008528
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)C(O)C1CNC2=C(N1)C(=O)NC(N)=N2

Dyspropterin
type: SmallMolecule
cellular location: Cytosol
entity reference: Dyspropterin

Reference/KEGG Compound C00272
type: UnificationXref
id: C00272
db: KEGG Compound

Reference/ChEBI CHEBI 17804
type: UnificationXref
id: CHEBI:17804
db: ChEBI

NADP
type: SmallMolecule
cellular location: Cytosol
entity reference: NADP

Reference/ChemSpider 58746
type: UnificationXref
id: 58746
db: ChemSpider

Reference/KEGG Compound C00835
type: UnificationXref
id: C00835
db: KEGG Compound

Reference/BioCyc CPD-374
type: UnificationXref
id: CPD-374
db: BioCyc

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Formamidopyrimidine nucleoside triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Formamidopyrimidine nucleoside triphosphate

Reference/KEGG Compound C04874
type: UnificationXref
id: C04874
db: KEGG Compound

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Formic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Formic acid

ChemicalStructure/PW C001388
type: ChemicalStructure
structure format: SMILES
structure data: CC(O)C(=O)C1CNC2=C(N1)C(=O)NC(N)=N2

Reference/BioCyc TETRA-H-BIOPTERIN
type: UnificationXref
id: TETRA-H-BIOPTERIN
db: BioCyc

Reference/CAS 10380-08-2
type: UnificationXref
id: 10380-08-2
db: CAS

Neopterin
type: SmallMoleculeReference
xref: Reference/KEGG Compound C05926
xref: Reference/CAS 2009-64-5
xref: Reference/HMDB HMDB0000845
xref: Reference/ChemSpider 4300
xref: Reference/PubChem-compound 4455
chemical formula: C9H11N5O4
molecular weight: 253.0811
structure: ChemicalStructure/PW C000673

GTP cyclohydrolase 1
type: ProteinReference
xref: Reference/UniProt Q19980
organism: Caenorhabditis elegans

Compound/PW C001388 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 6-Lactoyltetrahydropterin
stoichiometric coefficient: 1.0

Reference/BioCyc BIOPTERIN
type: UnificationXref
id: BIOPTERIN
db: BioCyc

Reference/CAS 1218-98-0
type: UnificationXref
id: 1218-98-0
db: CAS

Reference/SMPDB SMP0087486
type: UnificationXref
id: SMP0087486
db: SMPDB

GTP cyclohydrolase
type: Complex
component stoichiometry: Protein/17237 Cytosol/Stoichiometry/10.0
component stoichiometry: Protein/17243 Cytosol/Stoichiometry/10.0
cellular location: Cytosol
component: GTP cyclohydrolase 1
component: GTP cyclohydrolase I Feedback Regulatory Protein homolog

Reference/KEGG Compound C00044
type: UnificationXref
id: C00044
db: KEGG Compound

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/KEGG Compound C06148
type: UnificationXref
id: C06148
db: KEGG Compound

Caenorhabditis elegans
type: BioSource
xref: Reference/TAXONOMY 6239

Reference/HMDB HMDB0000027
type: UnificationXref
id: HMDB0000027
db: HMDB

GTP cyclohydrolase I Feedback Regulatory Protein homolog
type: ProteinReference
xref: Reference/UniProt D6RYD9
organism: Caenorhabditis elegans

Reference/PubChem-compound 18971002
type: UnificationXref
id: 18971002
db: PubChem-compound

Putative 6-pyruvoyl tetrahydrobiopterin synthase
type: ProteinReference
xref: Reference/UniProt Q2MGF4
organism: Caenorhabditis elegans

Unknown
type: ProteinReference
organism: Caenorhabditis elegans

Unknown
type: Protein
cellular location: Cytosol
entity reference: Unknown

Reference/HMDB HMDB0000142
type: UnificationXref
id: HMDB0000142
db: HMDB

Reference/TAXONOMY 6239
type: UnificationXref
id: 6239
db: TAXONOMY

Reference/BioCyc 6-1S2R-12-DIHYDROXY-3-TRIPHOSPHOOXY
type: UnificationXref
id: 6-1S2R-12-DIHYDROXY-3-TRIPHOSPHOOXY
db: BioCyc

Reference/ChEBI CHEBI 18372
type: UnificationXref
id: CHEBI:18372
db: ChEBI

ChemicalStructure/PW C000027
type: ChemicalStructure
structure format: SMILES
structure data: CC(O)C(O)C1=NC2=C(NC1)N=C(N)NC2=O

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Reference/KEGG Compound C03684
type: UnificationXref
id: C03684
db: KEGG Compound

Reference/KEGG Compound C00058
type: UnificationXref
id: C00058
db: KEGG Compound

Compound/PW C002952 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
stoichiometric coefficient: 1.0

Reference/UniProt D6RYD9
type: UnificationXref
id: D6RYD9
db: UniProt

Reference/KEGG Compound C04895
type: UnificationXref
id: C04895
db: KEGG Compound

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Formic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 30751
xref: Reference/ChemSpider 278
xref: Reference/PubChem-compound 18971002
xref: Reference/BioCyc FORMATE
xref: Reference/CAS 64-18-6
xref: Reference/KEGG Compound C00058
xref: Reference/HMDB HMDB0000142
chemical formula: CH2O2
molecular weight: 46.005478
structure: ChemicalStructure/PW C000092

L-xylulose reductase
type: ProteinReference
xref: Reference/UniProt Q27GP8
organism: Caenorhabditis elegans

Reference/HMDB HMDB0000038
type: UnificationXref
id: HMDB0000038
db: HMDB

2,5-Diaminopyrimidine nucleoside triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 929
xref: Reference/HMDB HMDB0006821
xref: Reference/KEGG Compound C05923
xref: Reference/PubChem-compound 440841
xref: Reference/ChemSpider 389683
chemical formula: C9H18N5O14P3
molecular weight: 513.0063
structure: ChemicalStructure/PW C002950

Formamidopyrimidine nucleoside triphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 440840
xref: Reference/HMDB HMDB0006822
xref: Reference/ChemSpider 389682
xref: Reference/KEGG Compound C05922
xref: Reference/ChEBI CHEBI 58104
chemical formula: C10H18N5O15P3
molecular weight: 541.0012
structure: ChemicalStructure/PW C002951

Dihydrobiopterin
type: SmallMolecule
cellular location: Cytosol
entity reference: Dihydrobiopterin

Reference/BioCyc FORMATE
type: UnificationXref
id: FORMATE
db: BioCyc

Quinoid DihydroPteridine Reductase
type: ProteinReference
xref: Reference/UniProt Q9XVJ3
organism: Caenorhabditis elegans

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

NAD
type: SmallMolecule
cellular location: Cytosol
entity reference: NAD

Dihydroneopterin triphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000980
xref: Reference/CAS 20574-65-6
xref: Reference/PubChem-compound 121885
xref: Reference/ChemSpider 108735
xref: Reference/BioCyc 6-1S2R-12-DIHYDROXY-3-TRIPHOSPHOOXY
xref: Reference/ChEBI CHEBI 18372
xref: Reference/KEGG Compound C04895
chemical formula: C9H16N5O13P3
molecular weight: 494.99576
structure: ChemicalStructure/PW C000779

Reference/PubChem-compound 659
type: UnificationXref
id: 659
db: PubChem-compound

2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
type: SmallMoleculeReference
xref: Reference/ChemSpider 389753
xref: Reference/HMDB HMDB0006823
xref: Reference/PubChem-compound 440923
xref: Reference/KEGG Compound C06148
chemical formula: C9H18N5O14P3
molecular weight: 513.0063
structure: ChemicalStructure/PW C002952

Compound/PW C000930 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dyspropterin
stoichiometric coefficient: 1.0

Neopterin
type: SmallMolecule
cellular location: Cytosol
entity reference: Neopterin

Reference/ChemSpider 1093
type: UnificationXref
id: 1093
db: ChemSpider

Putative 6-pyruvoyl tetrahydrobiopterin synthase
type: Protein
cellular location: Cytosol
entity reference: Putative 6-pyruvoyl tetrahydrobiopterin synthase

Reference/PathWhiz PW088505
type: UnificationXref
id: PW088505
db: PathWhiz

Reference/HMDB HMDB0006821
type: UnificationXref
id: HMDB0006821
db: HMDB

Reference/HMDB HMDB0006822
type: UnificationXref
id: HMDB0006822
db: HMDB

Reference/PubChem-compound 121885
type: UnificationXref
id: 121885
db: PubChem-compound

Reference/HMDB HMDB0006823
type: UnificationXref
id: HMDB0006823
db: HMDB

Compound/PW C000160 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sepiapterin
stoichiometric coefficient: 1.0

Reference/UniProt Q27GP8
type: UnificationXref
id: Q27GP8
db: UniProt

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000160
type: ChemicalStructure
structure format: SMILES
structure data: C[C@H](O)C(=O)C1=NC2=C(NC1)NC(N)=NC2=O

Compound/PW C002951 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Formamidopyrimidine nucleoside triphosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/UniProt Q93544
type: UnificationXref
id: Q93544
db: UniProt

Reference/CAS 17528-72-2
type: UnificationXref
id: 17528-72-2
db: CAS

Reference/HMDB HMDB0000845
type: UnificationXref
id: HMDB0000845
db: HMDB

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Protein/17237 Cytosol/Stoichiometry/10.0
type: Stoichiometry
physical entity: GTP cyclohydrolase 1
stoichiometric coefficient: 10.0

ChemicalStructure/PW C002950
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C002951
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 30751
type: UnificationXref
id: CHEBI:30751
db: ChEBI

ChemicalStructure/PW C002952
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc 6-PYRUVOYL-5678-TETRAHYDROPTERIN
type: UnificationXref
id: 6-PYRUVOYL-5678-TETRAHYDROPTERIN
db: BioCyc

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

ChemicalStructure/PW C000092
type: ChemicalStructure
structure format: SMILES
structure data: OC=O

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/PubChem-compound 128973
type: UnificationXref
id: 128973
db: PubChem-compound

Reference/KEGG Compound C00404
type: UnificationXref
id: C00404
db: KEGG Compound

Compound/PW C000779 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydroneopterin triphosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 6569
type: UnificationXref
id: 6569
db: ChemSpider

Reference/HMDB HMDB0012282
type: UnificationXref
id: HMDB0012282
db: HMDB

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

7,8-Dihydroneopterin
type: SmallMolecule
cellular location: Cytosol
entity reference: 7,8-Dihydroneopterin

Reference/BioCyc GTP
type: UnificationXref
id: GTP
db: BioCyc

Reference/ChEBI CHEBI 15372
type: UnificationXref
id: CHEBI:15372
db: ChEBI

ChemicalStructure/PW C000779
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000980
type: UnificationXref
id: HMDB0000980
db: HMDB

Reference/UniProt Q9XVJ3
type: UnificationXref
id: Q9XVJ3
db: UniProt

1-hydroxy-2-Oxopropyl tetrahydropterin
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0013642
xref: Reference/PubChem-compound 13846017
xref: Reference/ChemSpider 26777299
chemical formula: C9H13N5O3
molecular weight: 239.10184
structure: ChemicalStructure/PW C008528

Reference/HMDB HMDB0001273
type: UnificationXref
id: HMDB0001273
db: HMDB

3.5.4.16
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000092 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002950 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002951 Cytosol/Stoichiometry/1.0
right: Formic acid
right: 2,5-Diaminopyrimidine nucleoside triphosphate
spontaneous: false
EC number: 3.5.4.16
left: Formamidopyrimidine nucleoside triphosphate
left: Water
name: Formamidopyrimidine nucleoside triphosphate + Water → 2,5-Diaminopyrimidine nucleoside triphosphate + Formic acid
conversion direction: LEFT_TO_RIGHT

3.5.4.16
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000092 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000986 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002951 Cytosol/Stoichiometry/1.0
right: Formic acid
right: Formamidopyrimidine nucleoside triphosphate
spontaneous: false
EC number: 3.5.4.16
left: Guanosine triphosphate
left: Water
name: Guanosine triphosphate + Water → Formamidopyrimidine nucleoside triphosphate + Formic acid
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 64277
type: UnificationXref
id: CHEBI:64277
db: ChEBI

3.5.4.16
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002950 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002952 Cytosol/Stoichiometry/1.0
right: 2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
spontaneous: false
EC number: 3.5.4.16
left: 2,5-Diaminopyrimidine nucleoside triphosphate
name: 2,5-Diaminopyrimidine nucleoside triphosphate → 2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
conversion direction: LEFT_TO_RIGHT

3.5.4.16
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000779 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002952 Cytosol/Stoichiometry/1.0
right: Dihydroneopterin triphosphate
right: Water
spontaneous: false
EC number: 3.5.4.16
left: 2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
name: 2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine → Dihydroneopterin triphosphate + Water
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 983
type: UnificationXref
id: 983
db: PubChem-compound

4.2.3.12
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000779 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007822 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000930 Cytosol/Stoichiometry/1.0
right: Dyspropterin
right: PPPi
spontaneous: false
EC number: 4.2.3.12
left: Dihydroneopterin triphosphate
name: Dihydroneopterin triphosphate → Dyspropterin + PPPi
conversion direction: LEFT_TO_RIGHT

1.1.1.153
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000930 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C008528 Cytosol/Stoichiometry/1.0
right: 1-hydroxy-2-Oxopropyl tetrahydropterin
right: NADPH
spontaneous: false
EC number: 1.1.1.153
left: Dyspropterin
left: NADP
name: Dyspropterin + NADP → 1-hydroxy-2-Oxopropyl tetrahydropterin + NADPH
conversion direction: LEFT_TO_RIGHT

1.1.1.153
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000930 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001388 Cytosol/Stoichiometry/1.0
right: 6-Lactoyltetrahydropterin
right: NADPH
spontaneous: false
EC number: 1.1.1.153
left: Dyspropterin
left: NADP
name: Dyspropterin + NADP → 6-Lactoyltetrahydropterin + NADPH
conversion direction: LEFT_TO_RIGHT

1.1.1.21
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000930 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001388 Cytosol/Stoichiometry/1.0
right: 6-Lactoyltetrahydropterin
right: NADPH
spontaneous: false
EC number: 1.1.1.21
left: Dyspropterin
left: NADP
name: Dyspropterin + NADP → 6-Lactoyltetrahydropterin + NADPH
conversion direction: LEFT_TO_RIGHT

Reaction149359
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000930 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001388 Cytosol/Stoichiometry/1.0
right: 6-Lactoyltetrahydropterin
right: NADPH
spontaneous: false
left: Dyspropterin
left: NADP
name: Dyspropterin + NADP → 6-Lactoyltetrahydropterin + NADPH
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000986
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 440923
type: UnificationXref
id: 440923
db: PubChem-compound

Reference/ChemSpider 639
type: UnificationXref
id: 639
db: ChemSpider

Reference/CAS 64-18-6
type: UnificationXref
id: 64-18-6
db: CAS

Reference/KEGG Compound C02953
type: UnificationXref
id: C02953
db: KEGG Compound

7,8-Dihydroneopterin
type: SmallMoleculeReference
xref: Reference/CAS 1218-98-0
xref: Reference/PubChem-compound 659
xref: Reference/ChemSpider 639
xref: Reference/KEGG Compound C04874
xref: Reference/BioCyc DIHYDRONEOPTERIN-P3
xref: Reference/HMDB HMDB0002275
xref: Reference/ChEBI CHEBI 17001
chemical formula: C9H13N5O4
molecular weight: 255.09676
structure: ChemicalStructure/PW C001537

Compound/PW C000986 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine triphosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 26777299
type: UnificationXref
id: 26777299
db: ChemSpider

Reference/CAS 6779-87-9
type: UnificationXref
id: 6779-87-9
db: CAS

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Reaction1111
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001537 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000673 Cytosol/Stoichiometry/1.0
right: Neopterin
spontaneous: false
left: 7,8-Dihydroneopterin
name: 7,8-Dihydroneopterin → Neopterin
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C007822
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(=O)OP(O)(O)=O

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

PPPi
type: SmallMolecule
cellular location: Cytosol
entity reference: PPPi

2,5-Diaminopyrimidine nucleoside triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: 2,5-Diaminopyrimidine nucleoside triphosphate

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Reference/CAS 86-01-1
type: UnificationXref
id: 86-01-1
db: CAS

1.1.1.153
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001537 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000160 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
right: 7,8-Dihydroneopterin
right: NADP
spontaneous: false
EC number: 1.1.1.153
left: NADPH
left: Sepiapterin
name: NADPH + Sepiapterin ← 7,8-Dihydroneopterin + NADP
conversion direction: RIGHT_TO_LEFT

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Reaction149362
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001537 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000160 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
right: 7,8-Dihydroneopterin
right: NADPH
spontaneous: false
left: NADP
left: Sepiapterin
name: NADP + Sepiapterin ← 7,8-Dihydroneopterin + NADPH
conversion direction: RIGHT_TO_LEFT

1.1.1.153
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001388 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000019 Cytosol/Stoichiometry/1.0
right: Tetrahydrobiopterin
right: NADPH
spontaneous: false
EC number: 1.1.1.153
left: 6-Lactoyltetrahydropterin
left: NADP
name: 6-Lactoyltetrahydropterin + NADP → NADPH + Tetrahydrobiopterin
conversion direction: LEFT_TO_RIGHT

1.5.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001537 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000019 Cytosol/Stoichiometry/1.0
right: NADP
right: Tetrahydrobiopterin
right: Water
spontaneous: false
EC number: 1.5.1.3
left: 7,8-Dihydroneopterin
left: NADPH
name: 7,8-Dihydroneopterin + NADPH ← NADP + Tetrahydrobiopterin + Water
conversion direction: RIGHT_TO_LEFT

1.5.1.34
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000027 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000019 Cytosol/Stoichiometry/1.0
right: Dihydrobiopterin
right: NADPH
spontaneous: false
EC number: 1.5.1.34
left: NADP
left: Tetrahydrobiopterin
name: NADP + Tetrahydrobiopterin → Dihydrobiopterin + NADPH
conversion direction: LEFT_TO_RIGHT

1.1.1.153
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000721 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001388 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C008528 Cytosol/Stoichiometry/1.0
right: 1-hydroxy-2-Oxopropyl tetrahydropterin
right: NADH
spontaneous: false
EC number: 1.1.1.153
left: NAD
left: 6-Lactoyltetrahydropterin
name: 6-Lactoyltetrahydropterin + NAD ↔ 1-hydroxy-2-Oxopropyl tetrahydropterin + NADH
conversion direction: REVERSIBLE

Compound/PW C008528 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1-hydroxy-2-Oxopropyl tetrahydropterin
stoichiometric coefficient: 1.0

Reference/PubChem-compound 4455
type: UnificationXref
id: 4455
db: PubChem-compound

Reference/BioCyc P3I
type: UnificationXref
id: P3I
db: BioCyc

Compound/PW C001537 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 7,8-Dihydroneopterin
stoichiometric coefficient: 1.0

Compound/PW C000673 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Neopterin
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: Reference/UniProt Q9NAI5
organism: Caenorhabditis elegans

Reaction1105
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000160 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001388 Cytosol/Stoichiometry/1.0
right: Sepiapterin
spontaneous: false
left: 6-Lactoyltetrahydropterin
name: 6-Lactoyltetrahydropterin → Sepiapterin
conversion direction: LEFT_TO_RIGHT

Reference/CAS 17094-01-8
type: UnificationXref
id: 17094-01-8
db: CAS

Sepiapterin
type: SmallMolecule
cellular location: Cytosol
entity reference: Sepiapterin