Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Protein/16154 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Pyruvate kinase
stoichiometric coefficient: 4.0

Reference/PubChem-compound 439161
type: UnificationXref
id: 439161
db: PubChem-compound

Reference/UniProt Q19013
type: UnificationXref
id: Q19013
db: UniProt

Compound/PW C000691 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Xylulose 5-phosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 96860
type: UnificationXref
id: 96860
db: ChemSpider

Compound/PW C000500 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 30797
type: UnificationXref
id: CHEBI:30797
db: ChEBI

Reference/HMDB HMDB0001068
type: UnificationXref
id: HMDB0001068
db: HMDB

Tyrosine kinase regulation
type: Pathway
name: InhibitorySubPathway

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

Compound/PW C000125 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isocitric acid
stoichiometric coefficient: 1.0

Putative succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
type: ProteinReference
xref: Reference/UniProt O62215
organism: Caenorhabditis elegans

Compound/PW C000063 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Citric acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 50
type: UnificationXref
id: 50
db: ChemSpider

Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
type: ProteinReference
xref: Reference/UniProt P41956
organism: Caenorhabditis elegans

ReactionCatalysis139194
type: Catalysis
controller: Putative glutaminase 2
controlled: 3.5.1.2
control type: ACTIVATION

Fructose 1,6-bisphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001058
xref: Reference/BioCyc FRUCTOSE-16-DIPHOSPHATE
xref: Reference/CAS 488-69-7
xref: Reference/ChEBI CHEBI 16905
xref: Reference/ChemSpider 393165
xref: Reference/KEGG Compound C00354
xref: Reference/PubChem-compound 445557
chemical formula: C6H14O12P2
molecular weight: 339.99606
structure: ChemicalStructure/PW C000833

D-Ribulose 5-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Ribulose 5-phosphate

Compound/PW C000881 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 6-Phosphonoglucono-D-lactone
stoichiometric coefficient: 1.0

Reference/BioCyc OXALACETIC ACID
type: UnificationXref
id: OXALACETIC_ACID
db: BioCyc

Reference/HMDB HMDB0001072
type: UnificationXref
id: HMDB0001072
db: HMDB

Compound/PW C000479 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Ribulose 5-phosphate
stoichiometric coefficient: 1.0

Probable aconitate hydratase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q8WQF0
organism: Caenorhabditis elegans

Probable fumarate hydratase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Probable fumarate hydratase, mitochondrial

Reference/HMDB HMDB0003498
type: UnificationXref
id: HMDB0003498
db: HMDB

Probable mitochondrial pyruvate carrier 1
type: ProteinReference
xref: Reference/UniProt Q21828

2.7.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000077 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001083 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Glucose 6-phosphate
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.1.1
left: Adenosine triphosphate
left: D-Glucose
name: Adenosine triphosphate + D-Glucose → Adenosine diphosphate + Glucose 6-phosphate
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 5743
type: UnificationXref
id: 5743
db: ChemSpider

Reference/ChEBI CHEBI 16238
type: UnificationXref
id: CHEBI:16238
db: ChEBI

Reference/ChemSpider 5746
type: UnificationXref
id: 5746
db: ChemSpider

Reference/BioCyc HCO3
type: UnificationXref
id: HCO3
db: BioCyc

Reference/ChEBI CHEBI 15380
type: UnificationXref
id: CHEBI:15380
db: ChEBI

5.3.1.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001083 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000079 Cytosol/Stoichiometry/1.0
right: Glucose 6-phosphate
spontaneous: false
EC number: 5.3.1.9
left: Fructose 6-phosphate
name: Fructose 6-phosphate ↔ Glucose 6-phosphate
conversion direction: REVERSIBLE

Putative glutaminase 2
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Putative glutaminase 2

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

NADH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADH

Succinyl-CoA
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00091
xref: Reference/CAS 604-98-8
xref: Reference/ChemSpider 388307
xref: Reference/PubChem-compound 439161
xref: Reference/ChEBI CHEBI 15380
xref: Reference/BioCyc 3-METHYLBENZYLSUCCINYL-COA
xref: Reference/HMDB HMDB0001022
chemical formula: C25H40N7O19P3S
molecular weight: 867.1312
structure: ChemicalStructure/PW C000808

Reference/PubChem-compound 439184
type: UnificationXref
id: 439184
db: PubChem-compound

D-Ribose 5-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Ribose 5-phosphate

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/UniProt O62215
type: UnificationXref
id: O62215
db: UniProt

Compound/PW C001034 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Dihydrolipoyl dehydrogenase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Dihydrolipoyl dehydrogenase, mitochondrial

ChemicalStructure/PW C001083
type: ChemicalStructure
structure format: SMILES

Reference/CAS 97-67-6
type: UnificationXref
id: 97-67-6
db: CAS

Glutamate dehydrogenase 1, mitochondrial
type: Complex
component stoichiometry: Protein/15102 Mitochondrial Matrix/Stoichiometry/6.0
cellular location: Mitochondrial Matrix
component: Glutamate dehydrogenase

β-D-Glucose 6-phosphate
type: SmallMoleculeReference
xref: Reference/ChemSpider 388538
xref: Reference/KEGG Compound C01172
xref: Reference/ChEBI CHEBI 17719
xref: Reference/HMDB HMDB0003498
xref: Reference/PubChem-compound 439427
chemical formula: C6H13O9P
molecular weight: 260.02972
structure: ChemicalStructure/PW C001906

2.7.2.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000644 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000983 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine triphosphate
right: 3-Phosphoglyceric acid
spontaneous: false
EC number: 2.7.2.3
left: Adenosine diphosphate
left: Glyceric acid 1,3-biphosphate
name: Adenosine diphosphate + Glyceric acid 1,3-biphosphate → 3-Phosphoglyceric acid + Adenosine triphosphate
conversion direction: LEFT_TO_RIGHT

D-Sedoheptulose 7-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Sedoheptulose 7-phosphate

Reference/CAS 2646-35-7
type: UnificationXref
id: 2646-35-7
db: CAS

Reaction148996
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000644 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001870 Cytosol/Stoichiometry/1.0
right: 2-Phospho-D-glyceric acid
spontaneous: false
left: 3-Phosphoglyceric acid
name: 3-Phosphoglyceric acid ↔ 2-Phospho-D-glyceric acid
conversion direction: REVERSIBLE

4.2.1.11
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000180 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001870 Cytosol/Stoichiometry/1.0
right: Phosphoenolpyruvic acid
right: Water
spontaneous: false
EC number: 4.2.1.11
left: 2-Phospho-D-glyceric acid
name: 2-Phospho-D-glyceric acid ↔ Phosphoenolpyruvic acid + Water
conversion direction: REVERSIBLE

2.7.1.40
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000180 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: Phosphoenolpyruvic acid
spontaneous: false
EC number: 2.7.1.40
left: Adenosine triphosphate
left: Pyruvic acid
name: Adenosine triphosphate + Pyruvic acid ↔ Adenosine diphosphate + Phosphoenolpyruvic acid
conversion direction: REVERSIBLE

FAD
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: FAD

Reference/UniProt Q23500
type: UnificationXref
id: Q23500
db: UniProt

Compound/PW C001083 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glucose 6-phosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

Compound/PW C000063 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Citric acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 30769
type: UnificationXref
id: CHEBI:30769
db: ChEBI

Oxoglutarate dehydrogenase complex
type: Complex
component stoichiometry: Protein/14854 Mitochondrial Matrix/Stoichiometry/1.0
component stoichiometry: Protein/15716 Mitochondrial Matrix/Stoichiometry/1.0
component stoichiometry: Protein/14858 Mitochondrial Matrix/Stoichiometry/2.0
cellular location: Mitochondrial Matrix
component: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
component: Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial
component: Dihydrolipoyl dehydrogenase, mitochondrial

Reference/PubChem-compound 439167
type: UnificationXref
id: 439167
db: PubChem-compound

Compound/PW C000125 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isocitric acid
stoichiometric coefficient: 1.0

D-Glyceraldehyde 3-phosphate
type: SmallMoleculeReference
xref: Reference/BioCyc GAP
xref: Reference/ChEBI CHEBI 17138
xref: Reference/HMDB HMDB0001112
xref: Reference/ChemSpider 709
xref: Reference/KEGG Compound C00661
xref: Reference/PubChem-compound 729
xref: Reference/CAS 591-59-3
chemical formula: C3H7O6P
molecular weight: 169.99803
structure: ChemicalStructure/PW C000869

Reference/CAS 138-08-9
type: UnificationXref
id: 138-08-9
db: CAS

ChemicalStructure/PW C000808
type: ChemicalStructure
structure format: SMILES

ReactionCatalysis139156
type: Catalysis
controller: Succinate dehydrogenase
controlled: 1.3.5.1
control type: ACTIVATION

Reference/ChemSpider 1161
type: UnificationXref
id: 1161
db: ChemSpider

Reference/KEGG Compound C00231
type: UnificationXref
id: C00231
db: KEGG Compound

Reference/KEGG Compound C00236
type: UnificationXref
id: C00236
db: KEGG Compound

Compound/PW C001144 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Compound/PW C000122 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Lactic acid
stoichiometric coefficient: 1.0

Reference/BioCyc SUC
type: UnificationXref
id: SUC
db: BioCyc

Reference/CAS 7664-38-2
type: UnificationXref
id: 7664-38-2
db: CAS

TransKeTolase homolog
type: ProteinReference
xref: Reference/UniProt O17759
organism: Caenorhabditis elegans

ReactionCatalysis139153
type: Catalysis
controller: Fumarate hydratase, mitochondrial
controlled: 4.2.1.2
control type: ACTIVATION

ReactionCatalysis139152
type: Catalysis
controller: Succinyl-CoA ligase
controlled: Reaction148813
control type: ACTIVATION

ReactionCatalysis139155
type: Catalysis
controller: Pyruvate carboxylase, mitochondrial
controlled: 6.4.1.1
control type: ACTIVATION

ReactionCatalysis139154
type: Catalysis
controller: Malate dehydrogenase
controlled: Reaction148815
control type: ACTIVATION

Protein/17131 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Glucose-6-phosphate 1-dehydrogenase
stoichiometric coefficient: 4.0

ReactionCatalysis139151
type: Catalysis
controller: Oxoglutarate dehydrogenase complex
controlled: 1.2.4.2
control type: ACTIVATION

ReactionCatalysis139150
type: Catalysis
controller: Citrate synthase, mitochondrial
controlled: 2.3.3.1
control type: ACTIVATION

Compound/PW C000035 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonia
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Fumarate hydratase, mitochondrial
type: Complex
component stoichiometry: Protein/14897 Mitochondrial Matrix/Stoichiometry/4.0
cellular location: Mitochondrial Matrix
component: Probable fumarate hydratase, mitochondrial

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Protein/14892 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001906
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/UniProt Q6BET1
type: UnificationXref
id: Q6BET1
db: UniProt

Fructose 6-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Fructose 6-phosphate

Reference/PubChem-compound 439190
type: UnificationXref
id: 439190
db: PubChem-compound

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

NADPH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADPH

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Transaldolase
type: ProteinReference
xref: Reference/UniProt Q966C7
organism: Caenorhabditis elegans

Coenzyme A
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Coenzyme A

6-Phosphonoglucono-D-lactone
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001127
xref: Reference/PubChem-compound 439452
xref: Reference/ChemSpider 388559
xref: Reference/ChEBI CHEBI 16938
xref: Reference/KEGG Compound C01236
xref: Reference/CAS 2641-81-8
xref: Reference/BioCyc D-6-P-GLUCONO-DELTA-LACTONE
chemical formula: C6H11O9P
molecular weight: 258.01407
structure: ChemicalStructure/PW C000881

Reference/KEGG Compound C11378
type: UnificationXref
id: C11378
db: KEGG Compound

Coenzyme Q10
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001072
xref: Reference/BioCyc UBIQUINONE-10
xref: Reference/PubChem-compound 5281915
xref: Reference/ChemSpider 4445197
xref: Reference/CAS 303-98-0
xref: Reference/KEGG Compound C11378
xref: Reference/ChEBI CHEBI 46245
chemical formula: C59H90O4
molecular weight: 862.6839
structure: ChemicalStructure/PW C000846

Reference/ChemSpider 388411
type: UnificationXref
id: 388411
db: ChemSpider

D-Sedoheptulose 7-phosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001068
xref: Reference/ChemSpider 17216052
xref: Reference/BioCyc D-SEDOHEPTULOSE-7-P
xref: Reference/PubChem-compound 22833559
xref: Reference/ChEBI CHEBI 15721
xref: Reference/KEGG Compound C00281
xref: Reference/CAS 2646-35-7
chemical formula: C7H15O10P
molecular weight: 290.04028
structure: ChemicalStructure/PW C000843

Compound/PW C001316 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/PubChem-compound 107689
type: UnificationXref
id: 107689
db: PubChem-compound

Reference/UniProt P52899
type: UnificationXref
id: P52899
db: UniProt

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/BioCyc FRUCTOSE-6P
type: UnificationXref
id: FRUCTOSE-6P
db: BioCyc

Reference/KEGG Compound C00016
type: UnificationXref
id: C00016
db: KEGG Compound

Reference/KEGG Compound C00014
type: UnificationXref
id: C00014
db: KEGG Compound

Reference/ChEBI CHEBI 17363
type: UnificationXref
id: CHEBI:17363
db: ChEBI

Reference/UniProt P91427
type: UnificationXref
id: P91427
db: UniProt

Pyruvate carboxylase 1
type: ProteinReference
xref: Reference/UniProt O17732
organism: Caenorhabditis elegans

ReactionCatalysis139375
type: Catalysis
controller: Glucose-6-phosphate isomerase
controlled: 5.3.1.9
control type: ACTIVATION

ReactionCatalysis139371
type: Catalysis
controller: Phosphotransferase
controlled: 2.7.1.1
control type: ACTIVATION

Reference/ChEBI CHEBI 17138
type: UnificationXref
id: CHEBI:17138
db: ChEBI

ReactionCatalysis139149
type: Catalysis
controller: Pyruvate dehydrogenase complex
controlled: 1.2.4.1
control type: ACTIVATION

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

ReactionCatalysis139388
type: Catalysis
controller: Pyruvate kinase PKLR
controlled: 2.7.1.40
control type: ACTIVATION

ReactionCatalysis139387
type: Catalysis
controller: Enolase
controlled: 4.2.1.11
control type: ACTIVATION

Phosphate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Phosphate

Reference/KEGG Compound C00022
type: UnificationXref
id: C00022
db: KEGG Compound

Isocitrate dehydrogenase
type: Complex
component stoichiometry: Protein/14873 Mitochondrial Matrix/Stoichiometry/1.0
component stoichiometry: Protein/14870 Mitochondrial Matrix/Stoichiometry/2.0
cellular location: Mitochondrial Matrix
component: Probable isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
component: Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/KEGG Compound C01352
type: UnificationXref
id: C01352
db: KEGG Compound

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/KEGG Compound C00026
type: UnificationXref
id: C00026
db: KEGG Compound

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

Reference/ChEBI CHEBI 26078
type: UnificationXref
id: CHEBI:26078
db: ChEBI

Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
type: ProteinReference
xref: Reference/UniProt O44075
organism: Caenorhabditis elegans

ReactionCatalysis139383
type: Catalysis
controller: Probable phosphoglycerate kinase
controlled: 2.7.2.3
control type: ACTIVATION

ReactionCatalysis139386
type: Catalysis
controller: Unknown
controlled: Reaction148996
control type: ACTIVATION

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q34089
organism: Caenorhabditis elegans

L-Glutamic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: L-Glutamic acid

NADP
type: SmallMolecule
cellular location: Cytosol
entity reference: NADP

Protein/14854 Mitochondrial Matrix/Stoichiometry/60.0
type: Stoichiometry
physical entity: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
stoichiometric coefficient: 60.0

Reference/ChEBI CHEBI 48928
type: UnificationXref
id: CHEBI:48928
db: ChEBI

Reference/PubChem-compound 769
type: UnificationXref
id: 769
db: PubChem-compound

Succinate dehydrogenase
type: Complex
component stoichiometry: Protein/14921 Mitochondrial Matrix/Stoichiometry/1.0
component stoichiometry: Protein/14913 Mitochondrial Matrix/Stoichiometry/1.0
component stoichiometry: Protein/14928 Mitochondrial Matrix/Stoichiometry/1.0
component stoichiometry: Protein/14918 Mitochondrial Matrix/Stoichiometry/1.0
cellular location: Mitochondrial Matrix
component: Putative succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
component: Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
component: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
component: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

ChemicalStructure/PW C001019
type: ChemicalStructure
structure format: SMILES
structure data: O[C@H](COP(O)(O)=O)[C@@H](O)C=O

Reference/KEGG Compound C00031
type: UnificationXref
id: C00031
db: KEGG Compound

Reference/KEGG Compound C00279
type: UnificationXref
id: C00279
db: KEGG Compound

Reference/KEGG Compound C00036
type: UnificationXref
id: C00036
db: KEGG Compound

Reference/ChEBI CHEBI 18276
type: UnificationXref
id: CHEBI:18276
db: ChEBI

Reference/KEGG Compound C00035
type: UnificationXref
id: C00035
db: KEGG Compound

Reference/HMDB HMDB0000134
type: UnificationXref
id: HMDB0000134
db: HMDB

ChemicalStructure/PW C000174
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(O)=O

Compound/PW C000500 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamine
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00282
type: UnificationXref
id: C00282
db: KEGG Compound

Reference/KEGG Compound C00281
type: UnificationXref
id: C00281
db: KEGG Compound

Compound/PW C000463 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen carbonate
stoichiometric coefficient: 1.0

Warburg Effect
type: Pathway
pathway order: PathwayEnzymeReaction/2117279
pathway order: PathwayTransport/2117313
pathway order: PathwayTransport/2117314
pathway order: PathwayTransport/2117311
pathway order: PathwayTransport/2117312
pathway order: PathwayTransport/2117315
pathway order: PathwayEnzymeReaction/2117290
pathway order: PathwayEnzymeReaction/2117291
pathway order: PathwayEnzymeReaction/2117296
pathway order: PathwayEnzymeReaction/2117297
pathway order: PathwayEnzymeReaction/2117298
pathway order: PathwayEnzymeReaction/2117299
pathway order: PathwayEnzymeReaction/2117292
pathway order: PathwayEnzymeReaction/2117293
pathway order: PathwayEnzymeReaction/2117294
pathway order: PathwayEnzymeReaction/2117295
pathway order: PathwayEnzymeReaction/2117304
pathway order: PathwayEnzymeReaction/2117305
pathway order: PathwayEnzymeReaction/2117306
pathway order: PathwayEnzymeReaction/2117307
pathway order: PathwayEnzymeReaction/2117289
pathway order: PathwayEnzymeReaction/2117300
pathway order: PathwaySubPathway/109097
pathway order: PathwayEnzymeReaction/2117301
pathway order: PathwayEnzymeReaction/2117302
pathway order: PathwayEnzymeReaction/2117303
pathway order: PathwayEnzymeReaction/2117308
pathway order: PathwayEnzymeReaction/2117309
pathway order: PathwayEnzymeReaction/2117280
pathway order: PathwayTransport/2117310
pathway order: PathwayEnzymeReaction/2117285
pathway order: PathwayEnzymeReaction/2117286
pathway order: PathwayEnzymeReaction/2117287
pathway order: PathwayEnzymeReaction/2117288
pathway order: PathwayEnzymeReaction/2117281
pathway order: PathwayEnzymeReaction/2117282
pathway order: PathwayEnzymeReaction/2117283
pathway order: PathwayEnzymeReaction/2117284
pathway component: ReactionCatalysis139953
pathway component: 2.2.1.1
pathway component: 2.2.1.2
pathway component: ReactionCatalysis139954
pathway component: 4.1.2.13
pathway component: ReactionCatalysis139156
pathway component: TransportCatalysis1124
pathway component: ReactionCatalysis139957
pathway component: ReactionCatalysis139318
pathway component: ReactionCatalysis139956
pathway component: ReactionCatalysis139959
pathway component: Transport8294
pathway component: Transport8295
pathway component: Transport8296
pathway component: Transport8297
pathway component: ReactionCatalysis139153
pathway component: ReactionCatalysis139152
pathway component: ReactionCatalysis139155
pathway component: ReactionCatalysis139154
pathway component: 2.7.1.11
pathway component: ReactionCatalysis139151
pathway component: ReactionCatalysis139150
pathway component: ReactionCatalysis139194
pathway component: 5.3.1.9
pathway component: ReactionCatalysis139204
pathway component: ReactionCatalysis139644
pathway component: TransportCatalysis1139
pathway component: 3.5.1.2
pathway component: ReactionCatalysis168788
pathway component: ReactionCatalysis139643
pathway component: Reaction148931
pathway component: 1.2.4.1
pathway component: 2.3.3.1
pathway component: 1.2.4.2
pathway component: Reaction148813
pathway component: ReactionCatalysis139649
pathway component: 4.2.1.2
pathway component: Reaction148815
pathway component: 6.4.1.1
pathway component: 1.3.5.1
pathway component: ReactionCatalysis139656

Compound/PW C001019 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Erythrose 4-phosphate
stoichiometric coefficient: 1.0

D-Erythrose 4-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Erythrose 4-phosphate

Reference/KEGG Compound C00044
type: UnificationXref
id: C00044
db: KEGG Compound

Reference/KEGG Compound C00042
type: UnificationXref
id: C00042
db: KEGG Compound

L-Glutamine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Glutamine

Reference/ChemSpider 648
type: UnificationXref
id: 648
db: ChemSpider

Compound/PW C000932 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: FADH
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00288
type: UnificationXref
id: C00288
db: KEGG Compound

Reference/CAS 56-85-9
type: UnificationXref
id: 56-85-9
db: CAS

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Reference/CAS 604-98-8
type: UnificationXref
id: 604-98-8
db: CAS

Reference/UniProt P41994
type: UnificationXref
id: P41994
db: UniProt

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

Compound/PW C000134 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxoglutaric acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001473
type: UnificationXref
id: HMDB0001473
db: HMDB

ChemicalStructure/PW C000180
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C(=C)OP(O)(O)=O

3-Phosphoglyceric acid
type: SmallMoleculeReference
xref: Reference/BioCyc G3P
xref: Reference/PubChem-compound 724
xref: Reference/ChEBI CHEBI 17050
xref: Reference/ChemSpider 704
xref: Reference/CAS 820-11-1
xref: Reference/KEGG Compound C00597
xref: Reference/HMDB HMDB0000807
chemical formula: C3H7O7P
molecular weight: 185.99294
structure: ChemicalStructure/PW C000644

Reference/BioCyc FUM
type: UnificationXref
id: FUM
db: BioCyc

ChemicalStructure/PW C000148
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC(=O)C(O)=O

Reference/ChEBI CHEBI 4170
type: UnificationXref
id: CHEBI:4170
db: ChEBI

Reference/ChEBI CHEBI 18012
type: UnificationXref
id: CHEBI:18012
db: ChEBI

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Reference/HMDB HMDB0000156
type: UnificationXref
id: HMDB0000156
db: HMDB

Compound/PW C000095 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Glucose-6-phosphate 1-dehydrogenase
type: ProteinReference
xref: Reference/UniProt Q27464
organism: Caenorhabditis elegans

Reference/HMDB HMDB0001248
type: UnificationXref
id: HMDB0001248
db: HMDB

Reference/UniProt Q966C7
type: UnificationXref
id: Q966C7
db: UniProt

Pyruvic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Pyruvic acid

Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Putative 6-phosphogluconolactonase
type: ProteinReference
xref: Reference/UniProt Q2EEL9
organism: Caenorhabditis elegans

Compound/PW C001015 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 6-Phosphogluconic acid
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Phosphoric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphoric acid

Reference/BioCyc DPG
type: UnificationXref
id: DPG
db: BioCyc

Reference/BioCyc DIHYDROXY-ACETONE-PHOSPHATE
type: UnificationXref
id: DIHYDROXY-ACETONE-PHOSPHATE
db: BioCyc

Protein/15716 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001006
type: ChemicalStructure
structure format: SMILES
structure data: COC1=C(O)C(C)=C(C\C=C(/C)CCC=C(C)C)C(O)=C1OC

Reference/KEGG Compound C00064
type: UnificationXref
id: C00064
db: KEGG Compound

Compound/PW C000077 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glucose
stoichiometric coefficient: 1.0

Glutamate dehydrogenase
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Glutamate dehydrogenase

NAD
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: NAD

ChemicalStructure/PW C000164
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)C(O)=O

Probable-ribose 5-phosphate isomerase
type: ProteinReference
xref: Reference/UniProt P41994
organism: Caenorhabditis elegans

Reference/ChemSpider 663
type: UnificationXref
id: 663
db: ChemSpider

Reference/KEGG Compound C00074
type: UnificationXref
id: C00074
db: KEGG Compound

ChemicalStructure/PW C001015
type: ChemicalStructure
structure format: SMILES

3-Phosphoglyceric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: 3-Phosphoglyceric acid

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Compound/PW C000808 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinyl-CoA
stoichiometric coefficient: 1.0

Reference/PubChem-compound 724
type: UnificationXref
id: 724
db: PubChem-compound

Protein/16154 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Pyruvate kinase
stoichiometric coefficient: 2.0

TransportCatalysis1124
type: Catalysis
controller: Unknown
controlled: Transport8223
control type: ACTIVATION

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Probable-ribose 5-phosphate isomerase
type: Protein
cellular location: Cytosol
entity reference: Probable-ribose 5-phosphate isomerase

Reference/KEGG Compound C00085
type: UnificationXref
id: C00085
db: KEGG Compound

Reference/KEGG Compound C01172
type: UnificationXref
id: C01172
db: KEGG Compound

Reference/PubChem-compound 729
type: UnificationXref
id: 729
db: PubChem-compound

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Adenosine diphosphate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Adenosine diphosphate

Reference/HMDB HMDB0001022
type: UnificationXref
id: HMDB0001022
db: HMDB

TransportCatalysis1139
type: Catalysis
controller: Facilitated glucose transporter protein 1
controlled: Transport8294
control type: ACTIVATION

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/BioCyc PYRUVATE
type: UnificationXref
id: PYRUVATE
db: BioCyc

Reference/BioCyc QH2
type: UnificationXref
id: QH2
db: BioCyc

D-Ribulose 5-phosphate
type: SmallMoleculeReference
xref: Reference/CAS 4151-19-3
xref: Reference/BioCyc RIBULOSE-5P
xref: Reference/KEGG Compound C00199
xref: Reference/PubChem-compound 439184
xref: Reference/HMDB HMDB0000618
xref: Reference/ChEBI CHEBI 17363
chemical formula: C5H11O8P
molecular weight: 230.01915
structure: ChemicalStructure/PW C000479

ReactionCatalysis168788
type: Catalysis
controller: Isocitrate dehydrogenase
controlled: 1.1.1.41
control type: ACTIVATION

Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00092
type: UnificationXref
id: C00092
db: KEGG Compound

Reference/KEGG Compound C00091
type: UnificationXref
id: C00091
db: KEGG Compound

Reference/BioCyc G3P
type: UnificationXref
id: G3P
db: BioCyc

Protein/14921 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
stoichiometric coefficient: 1.0

Compound/PW C001006 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: QH2
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 4167
type: UnificationXref
id: CHEBI:4167
db: ChEBI

Reference/UniProt O45747
type: UnificationXref
id: O45747
db: UniProt

Reference/HMDB HMDB0001270
type: UnificationXref
id: HMDB0001270
db: HMDB

Enolase
type: Protein
cellular location: Cytosol
entity reference: Enolase

Protein/14907 Mitochondrial Matrix/Stoichiometry/4.0
type: Stoichiometry
physical entity: Pyruvate carboxylase 1
stoichiometric coefficient: 4.0

Reference/UniProt P41956
type: UnificationXref
id: P41956
db: UniProt

Reference/HMDB HMDB0001273
type: UnificationXref
id: HMDB0001273
db: HMDB

Isocitric acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Isocitric acid

L-Glutamine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: L-Glutamine

Compound/PW C000869 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glyceraldehyde 3-phosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000190
type: UnificationXref
id: HMDB0000190
db: HMDB

Succinic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Succinic acid

Reference/BioCyc XYLULOSE-5-PHOSPHATE
type: UnificationXref
id: XYLULOSE-5-PHOSPHATE
db: BioCyc

Coenzyme Q10
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Coenzyme Q10

Reference/ChEBI CHEBI 18050
type: UnificationXref
id: CHEBI:18050
db: ChEBI

TransportCatalysis1140
type: Catalysis
controller: MonoCarboxylate Transporter family
controlled: Transport8295
control type: ACTIVATION

Reference/BioCyc FADH2
type: UnificationXref
id: FADH2
db: BioCyc

Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

Reference/HMDB HMDB0000193
type: UnificationXref
id: HMDB0000193
db: HMDB

TransportCatalysis1141
type: Catalysis
controller: Excitatory amino acid transporter
controlled: Transport8297
control type: ACTIVATION

Reference/ChemSpider 393165
type: UnificationXref
id: 393165
db: ChemSpider

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Xylulose 5-phosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000868
xref: Reference/KEGG Compound C00231
xref: Reference/BioCyc XYLULOSE-5-PHOSPHATE
xref: Reference/PubChem-compound 439190
xref: Reference/CAS 60802-29-1
xref: Reference/ChEBI CHEBI 16332
xref: Reference/ChemSpider 388330
chemical formula: C5H11O8P
molecular weight: 230.01915
structure: ChemicalStructure/PW C000691

Compound/PW C000122 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Lactic acid
stoichiometric coefficient: 1.0

1.1.1.44
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001015 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000479 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
right: D-Ribulose 5-phosphate
right: Carbon dioxide
right: NADPH
spontaneous: false
EC number: 1.1.1.44
left: 6-Phosphogluconic acid
left: NADP
name: 6-Phosphogluconic acid + NADP → Carbon dioxide + D-Ribulose 5-phosphate + NADPH
conversion direction: LEFT_TO_RIGHT

5.3.1.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001191 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000479 Cytosol/Stoichiometry/1.0
right: D-Ribose 5-phosphate
spontaneous: false
EC number: 5.3.1.6
left: D-Ribulose 5-phosphate
name: D-Ribulose 5-phosphate ↔ D-Ribose 5-phosphate
conversion direction: REVERSIBLE

Reference/UniProt Q3S1I8
type: UnificationXref
id: Q3S1I8
db: UniProt

Reference/PubChem-compound 970
type: UnificationXref
id: 970
db: PubChem-compound

Pyruvate kinase PKM
type: Complex
component stoichiometry: Protein/16154 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Pyruvate kinase
name: SubPathwayInhibitor

Reference/HMDB HMDB0001058
type: UnificationXref
id: HMDB0001058
db: HMDB

Acetyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Acetyl-CoA

Hydrogen carbonate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000595
xref: Reference/ChEBI CHEBI 17544
xref: Reference/PubChem-compound 769
xref: Reference/BioCyc HCO3
xref: Reference/ChemSpider 749
xref: Reference/CAS 71-52-3
xref: Reference/KEGG Compound C00288
chemical formula: CHO3
molecular weight: 60.99257
structure: ChemicalStructure/PW C000463

Reference/CAS 820-11-1
type: UnificationXref
id: 820-11-1
db: CAS

ChemicalStructure/PW C001051
type: ChemicalStructure
structure format: SMILES
structure data: [H][H]

Reference/HMDB HMDB0002142
type: UnificationXref
id: HMDB0002142
db: HMDB

Protein/16129 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Glucose-6-phosphate isomerase
stoichiometric coefficient: 2.0

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

2.2.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001191 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000843 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000869 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000691 Cytosol/Stoichiometry/1.0
right: Xylulose 5-phosphate
right: D-Ribose 5-phosphate
spontaneous: false
EC number: 2.2.1.1
left: D-Sedoheptulose 7-phosphate
left: D-Glyceraldehyde 3-phosphate
name: D-Glyceraldehyde 3-phosphate + D-Sedoheptulose 7-phosphate ↔ D-Ribose 5-phosphate + Xylulose 5-phosphate
conversion direction: REVERSIBLE

2.2.1.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001019 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000843 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000869 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000079 Cytosol/Stoichiometry/1.0
right: D-Sedoheptulose 7-phosphate
right: D-Glyceraldehyde 3-phosphate
spontaneous: false
EC number: 2.2.1.2
left: D-Erythrose 4-phosphate
left: Fructose 6-phosphate
name: D-Erythrose 4-phosphate + Fructose 6-phosphate ↔ D-Glyceraldehyde 3-phosphate + D-Sedoheptulose 7-phosphate
conversion direction: REVERSIBLE

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

4.1.2.13
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001134 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000833 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000869 Cytosol/Stoichiometry/1.0
right: Dihydroxyacetone phosphate
right: D-Glyceraldehyde 3-phosphate
spontaneous: false
EC number: 4.1.2.13
left: Fructose 1,6-bisphosphate
name: Fructose 1,6-bisphosphate ↔ D-Glyceraldehyde 3-phosphate + Dihydroxyacetone phosphate
conversion direction: REVERSIBLE

Reference/PubChem-compound 446013
type: UnificationXref
id: 446013
db: PubChem-compound

Reference/ChEBI CHEBI 15721
type: UnificationXref
id: CHEBI:15721
db: ChEBI

L-Malic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: L-Malic acid

Compound/PW C000174 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinic acid
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000691
type: ChemicalStructure
structure format: SMILES
structure data: OCC(=O)[C@@H](O)[C@H](O)COP(O)(O)=O

Reference/PubChem-compound 21883788
type: UnificationXref
id: 21883788
db: PubChem-compound

Guanosine triphosphate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Guanosine triphosphate

Ammonia
type: SmallMoleculeReference
xref: Reference/BioCyc AMMONIA
xref: Reference/CAS 7664-41-7
xref: Reference/HMDB HMDB0000051
xref: Reference/PubChem-compound 222
xref: Reference/KEGG Compound C00014
xref: Reference/ChEBI CHEBI 16134
xref: Reference/ChemSpider 217
chemical formula: H3N
molecular weight: 17.026548
structure: ChemicalStructure/PW C000035

Putative 6-phosphogluconolactonase
type: Protein
cellular location: Cytosol
entity reference: Putative 6-phosphogluconolactonase

2.7.1.11
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000833 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000079 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: Fructose 1,6-bisphosphate
spontaneous: false
EC number: 2.7.1.11
left: Adenosine triphosphate
left: Fructose 6-phosphate
name: Adenosine triphosphate + Fructose 6-phosphate → Adenosine diphosphate + Fructose 1,6-bisphosphate
conversion direction: LEFT_TO_RIGHT

Compound/PW C000180 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoenolpyruvic acid
stoichiometric coefficient: 1.0

5.3.1.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001906 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001083 Cytosol/Stoichiometry/1.0
right: Glucose 6-phosphate
spontaneous: false
EC number: 5.3.1.9
left: β-D-Glucose 6-phosphate
name: β-D-Glucose 6-phosphate ↔ Glucose 6-phosphate
conversion direction: REVERSIBLE

Reference/UniProt O44451
type: UnificationXref
id: O44451
db: UniProt

ReactionCatalysis139644
type: Catalysis
controller: Probable-ribose 5-phosphate isomerase
controlled: 5.3.1.6
control type: ACTIVATION

Glutamate dehydrogenase
type: ProteinReference
xref: Reference/UniProt Q23621
organism: Caenorhabditis elegans

ReactionCatalysis139643
type: Catalysis
controller: 6-phosphogluconate dehydrogenase, decarboxylating
controlled: 1.1.1.44
control type: ACTIVATION

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/PubChem-compound 5961
type: UnificationXref
id: 5961
db: PubChem-compound

ReactionCatalysis139649
type: Catalysis
controller: Transketolase
controlled: 2.2.1.1
control type: ACTIVATION

Reference/CAS 643-13-0
type: UnificationXref
id: 643-13-0
db: CAS

Reference/CAS 1981-49-3
type: UnificationXref
id: 1981-49-3
db: CAS

Compound/PW C000148 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxalacetic acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Dihydroxyacetone phosphate
type: SmallMoleculeReference
xref: Reference/BioCyc DIHYDROXY-ACETONE-PHOSPHATE
xref: Reference/PubChem-compound 668
xref: Reference/ChEBI CHEBI 16108
xref: Reference/KEGG Compound C00111
xref: Reference/CAS 57-04-5
xref: Reference/ChemSpider 648
xref: Reference/HMDB HMDB0001473
chemical formula: C3H7O6P
molecular weight: 169.99803
structure: ChemicalStructure/PW C001134

Reference/PubChem-compound 51
type: UnificationXref
id: 51
db: PubChem-compound

FADH
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: FADH

ChemicalStructure/PW C000463
type: ChemicalStructure
structure format: SMILES
structure data: OC([O-])=O

Reference/SMPDB SMP0087527
type: UnificationXref
id: SMP0087527
db: SMPDB

Reference/ChEBI CHEBI 46245
type: UnificationXref
id: CHEBI:46245
db: ChEBI

Reference/UniProt Q2EEL9
type: UnificationXref
id: Q2EEL9
db: UniProt

1.1.1.27
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000122 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytosol/Stoichiometry/1.0
right: Pyruvic acid
right: Hydrogen Ion
right: NADH
spontaneous: false
EC number: 1.1.1.27
left: NAD
left: L-Lactic acid
name: L-Lactic acid + NAD ↔ Hydrogen Ion + NADH + Pyruvic acid
conversion direction: REVERSIBLE

Reference/HMDB HMDB0001401
type: UnificationXref
id: HMDB0001401
db: HMDB

Isocitrate dehydrogenase [NADP]
type: Protein
cellular location: Cytosol
entity reference: Isocitrate dehydrogenase [NADP]

Protein/17156 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: TransKeTolase homolog
stoichiometric coefficient: 2.0

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: O4P
molecular weight: 94.95342
structure: ChemicalStructure/PW C001104

Glucose-6-phosphate isomerase
type: Complex
component stoichiometry: Protein/16129 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Glucose-6-phosphate isomerase

Reference/PubChem-compound 6830
type: UnificationXref
id: 6830
db: PubChem-compound

TransportCatalysis1118
type: Catalysis
controller: Probable mitochondrial pyruvate carrier 1
controlled: Transport8147
control type: ACTIVATION

Reference/ChEBI CHEBI 15946
type: UnificationXref
id: CHEBI:15946
db: ChEBI

Protein/14850 Mitochondrial Matrix/Stoichiometry/60.0
type: Stoichiometry
physical entity: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
stoichiometric coefficient: 60.0

Unknown
type: Protein
entity reference: Unknown

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Carbon dioxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbon dioxide

Reference/ChemSpider 217
type: UnificationXref
id: 217
db: ChemSpider

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])([O-])=O

Fructose 6-phosphate
type: SmallMoleculeReference
xref: Reference/CAS 643-13-0
xref: Reference/HMDB HMDB0000124
xref: Reference/KEGG Compound C00085
xref: Reference/ChEBI CHEBI 15946
xref: Reference/BioCyc FRUCTOSE-6P
xref: Reference/PubChem-compound 69507
xref: Reference/ChemSpider 62713
chemical formula: C6H13O9P
molecular weight: 260.02972
structure: ChemicalStructure/PW C000079

Reference/UniProt Q8WQF0
type: UnificationXref
id: Q8WQF0
db: UniProt

Reference/ChEBI CHEBI 30915
type: UnificationXref
id: CHEBI:30915
db: ChEBI

Compound/PW C001051 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen
stoichiometric coefficient: 1.0

D-Glucose
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000122
xref: Reference/PubChem-compound 5793
xref: Reference/CAS 2280-44-6
xref: Reference/ChemSpider 5589
xref: Reference/ChEBI CHEBI 4167
xref: Reference/BioCyc GLC
xref: Reference/KEGG Compound C00031
chemical formula: C6H12O6
molecular weight: 180.06339
structure: ChemicalStructure/PW C000077

Reference/UniProt Q9U1Q2
type: UnificationXref
id: Q9U1Q2
db: UniProt

Pyruvate kinase PKLR
type: Complex
component stoichiometry: Protein/16154 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Pyruvate kinase
name: SubPathwayInhibition

L-Glutamine
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: L-Glutamine

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Probable isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Probable isocitrate dehydrogenase [NAD] subunit beta, mitochondrial

Reference/GENE ONTOLOGY GO 0005759
type: UnificationXref
id: GO:0005759
db: GENE ONTOLOGY

Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
type: UnificationXref
id: GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
db: BioCyc

Compound/PW C000164 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 1.0

Fumaric acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000134
xref: Reference/ChemSpider 10197150
xref: Reference/CAS 110-17-8
xref: Reference/PubChem-compound 21883788
xref: Reference/KEGG Compound C00122
xref: Reference/BioCyc FUM
xref: Reference/ChEBI CHEBI 18012
chemical formula: C4H4O4
molecular weight: 116.010956
structure: ChemicalStructure/PW C000088

Reference/ChEBI CHEBI 15741
type: UnificationXref
id: CHEBI:15741
db: ChEBI

Oxoglutaric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxoglutaric acid

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Reference/PubChem-compound 1110
type: UnificationXref
id: 1110
db: PubChem-compound

Reference/HMDB HMDB0001201
type: UnificationXref
id: HMDB0001201
db: HMDB

Reference/HMDB HMDB0000595
type: UnificationXref
id: HMDB0000595
db: HMDB

Reference/PubChem-compound 5958
type: UnificationXref
id: 5958
db: PubChem-compound

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

Reference/ChEBI CHEBI 15996
type: UnificationXref
id: CHEBI:15996
db: ChEBI

Glyceraldehyde-3-phosphate dehydrogenase
type: Complex
component stoichiometry: Protein/15680 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Glyceraldehyde-3-phosphate dehydrogenase 3

Protein/14858 Mitochondrial Matrix/Stoichiometry/24.0
type: Stoichiometry
physical entity: Dihydrolipoyl dehydrogenase, mitochondrial
stoichiometric coefficient: 24.0

ChemicalStructure/PW C000479
type: ChemicalStructure
structure format: SMILES
structure data: OCC(=O)[C@H](O)[C@H](O)COP(O)(O)=O

Reference/HMDB HMDB0000122
type: UnificationXref
id: HMDB0000122
db: HMDB

Transaldolase
type: Complex
component stoichiometry: Protein/17161 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Transaldolase

Reference/HMDB HMDB0000124
type: UnificationXref
id: HMDB0000124
db: HMDB

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Reference/UniProt Q27464
type: UnificationXref
id: Q27464
db: UniProt

Citric acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 30769
xref: Reference/BioCyc CIT
xref: Reference/HMDB HMDB0000094
xref: Reference/PubChem-compound 19782904
xref: Reference/KEGG Compound C00158
xref: Reference/CAS 77-92-9
xref: Reference/ChemSpider 305
chemical formula: C6H8O7
molecular weight: 192.02701
structure: ChemicalStructure/PW C000063

ChemicalStructure/PW C000843
type: ChemicalStructure
structure format: SMILES

Compound/PW C000414 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 82615
type: UnificationXref
id: 82615
db: ChemSpider

ChemicalStructure/PW C000846
type: ChemicalStructure
structure format: SMILES
structure data: COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(\C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Reference/ChEBI CHEBI 52742
type: UnificationXref
id: CHEBI:52742
db: ChEBI

Mitochondrial Matrix
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005759

Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
type: ProteinReference
xref: Reference/UniProt P53596
organism: Caenorhabditis elegans

D-Glucose
type: SmallMolecule
cellular location: Extracellular Space
entity reference: D-Glucose

Probable fumarate hydratase, mitochondrial
type: ProteinReference
xref: Reference/UniProt O17214
organism: Caenorhabditis elegans

Reference/BioCyc D-SEDOHEPTULOSE-7-P
type: UnificationXref
id: D-SEDOHEPTULOSE-7-P
db: BioCyc

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial
type: ProteinReference
xref: Reference/UniProt P53589
organism: Caenorhabditis elegans

Reference/PubChem-compound 222656
type: UnificationXref
id: 222656
db: PubChem-compound

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

Protein/14870 Mitochondrial Matrix/Stoichiometry/2.0
type: Stoichiometry
physical entity: Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
stoichiometric coefficient: 2.0

Reference/ChemSpider 1078
type: UnificationXref
id: 1078
db: ChemSpider

Pyruvate carboxylase, mitochondrial
type: Complex
component stoichiometry: Protein/14907 Mitochondrial Matrix/Stoichiometry/4.0
cellular location: Mitochondrial Matrix
component: Pyruvate carboxylase 1

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

Reference/PubChem-compound 643975
type: UnificationXref
id: 643975
db: PubChem-compound

β-D-Glucose 6-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: β-D-Glucose 6-phosphate

1.1.1.41
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000125 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
right: Carbon dioxide
right: Oxoglutaric acid
right: NADH
right: Hydrogen Ion
spontaneous: false
EC number: 1.1.1.41
left: Isocitric acid
left: NAD
name: Isocitric acid + NAD → Carbon dioxide + Hydrogen Ion + NADH + Oxoglutaric acid
conversion direction: LEFT_TO_RIGHT

Reference/CAS 127-17-3
type: UnificationXref
id: 127-17-3
db: CAS

Reference/UniProt O17328
type: UnificationXref
id: O17328
db: UniProt

Reference/ChEBI CHEBI 17719
type: UnificationXref
id: CHEBI:17719
db: ChEBI

Reference/UniProt D3YT81
type: UnificationXref
id: D3YT81
db: UniProt

Glyceraldehyde-3-phosphate dehydrogenase 3
type: Protein
cellular location: Cytosol
entity reference: Glyceraldehyde-3-phosphate dehydrogenase 3

Reference/BioCyc D-6-P-GLUCONO-DELTA-LACTONE
type: UnificationXref
id: D-6-P-GLUCONO-DELTA-LACTONE
db: BioCyc

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

Reference/UniProt O44075
type: UnificationXref
id: O44075
db: UniProt

ChemicalStructure/PW C000833
type: ChemicalStructure
structure format: SMILES

Reference/UniProt Q93353
type: UnificationXref
id: Q93353
db: UniProt

6-phosphofructokinase, liver type
type: Complex
component stoichiometry: Protein/15630 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: ATP-dependent 6-phosphofructokinase 1

Reference/BioCyc GLC-6-P
type: UnificationXref
id: GLC-6-P
db: BioCyc

D-Ribose 5-phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00117
xref: Reference/ChEBI CHEBI 52742
xref: Reference/ChemSpider 388313
xref: Reference/HMDB HMDB0001548
xref: Reference/BioCyc RIBOSE-5P
xref: Reference/PubChem-compound 439167
xref: Reference/CAS 4300-28-1
chemical formula: C5H11O8P
molecular weight: 230.01915
structure: ChemicalStructure/PW C001191

Reference/CAS 1333-74-0
type: UnificationXref
id: 1333-74-0
db: CAS

Reference/ChEBI CHEBI 17544
type: UnificationXref
id: CHEBI:17544
db: ChEBI

Reference/BioCyc 2-KETOGLUTARATE
type: UnificationXref
id: 2-KETOGLUTARATE
db: BioCyc

Protein/17674 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Isocitrate dehydrogenase [NADP]
stoichiometric coefficient: 2.0

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

ChemicalStructure/PW C000644
type: ChemicalStructure
structure format: SMILES
structure data: OC(COP(O)(O)=O)C(O)=O

Reference/CAS 110-15-6
type: UnificationXref
id: 110-15-6
db: CAS

Probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial
type: ProteinReference
xref: Reference/UniProt P52899
organism: Caenorhabditis elegans

Compound/PW C000846 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme Q10
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q19749
organism: Caenorhabditis elegans

ReactionCatalysis139204
type: Catalysis
controller: Glutamate dehydrogenase 1, mitochondrial
controlled: 1.4.1.3
control type: ACTIVATION

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
type: ProteinReference
xref: Reference/UniProt O44451
organism: Caenorhabditis elegans

Reference/ChemSpider 6569
type: UnificationXref
id: 6569
db: ChemSpider

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

1.2.4.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Mitochondrial Matrix/Stoichiometry/1.0
right: Acetyl-CoA
right: Carbon dioxide
right: NADH
spontaneous: false
EC number: 1.2.4.1
left: Pyruvic acid
left: Coenzyme A
left: NAD
name: Coenzyme A + NAD + Pyruvic acid → Acetyl-CoA + Carbon dioxide + NADH
conversion direction: LEFT_TO_RIGHT

2.3.3.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000063 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000148 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
right: Coenzyme A
right: Citric acid
spontaneous: false
EC number: 2.3.3.1
left: Acetyl-CoA
left: Water
left: Oxalacetic acid
name: Acetyl-CoA + Oxalacetic acid + Water → Citric acid + Coenzyme A
conversion direction: LEFT_TO_RIGHT

1.2.4.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000808 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
right: Succinyl-CoA
right: Carbon dioxide
right: NADH
right: Hydrogen Ion
spontaneous: false
EC number: 1.2.4.2
left: Coenzyme A
left: Oxoglutaric acid
left: NAD
name: Coenzyme A + NAD + Oxoglutaric acid → Carbon dioxide + Hydrogen Ion + NADH + Succinyl-CoA
conversion direction: LEFT_TO_RIGHT

Reaction148813
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000808 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000986 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000936 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000174 Mitochondrial Matrix/Stoichiometry/1.0
right: Succinic acid
right: Coenzyme A
right: Guanosine triphosphate
spontaneous: false
left: Succinyl-CoA
left: Phosphate
left: Guanosine diphosphate
name: Guanosine diphosphate + Phosphate + Succinyl-CoA ↔ Coenzyme A + Guanosine triphosphate + Succinic acid
conversion direction: REVERSIBLE

Reference/ChEBI CHEBI 17552
type: UnificationXref
id: CHEBI:17552
db: ChEBI

4.2.1.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000101 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000088 Mitochondrial Matrix/Stoichiometry/1.0
right: Fumaric acid
right: Water
spontaneous: false
EC number: 4.2.1.2
left: L-Malic acid
name: L-Malic acid ↔ Fumaric acid + Water
conversion direction: REVERSIBLE

Reaction148815
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000101 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000148 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
right: Oxalacetic acid
right: NADH
right: Hydrogen Ion
spontaneous: false
left: L-Malic acid
left: NAD
name: L-Malic acid + NAD ↔ Hydrogen Ion + NADH + Oxalacetic acid
conversion direction: REVERSIBLE

6.4.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001034 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000148 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000463 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Mitochondrial Matrix/Stoichiometry/1.0
right: Oxalacetic acid
right: Phosphate
right: Adenosine diphosphate
spontaneous: false
EC number: 6.4.1.1
left: Pyruvic acid
left: Adenosine triphosphate
left: Hydrogen carbonate
name: Adenosine triphosphate + Hydrogen carbonate + Pyruvic acid → Adenosine diphosphate + Oxalacetic acid + Phosphate
conversion direction: LEFT_TO_RIGHT

1.3.5.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001006 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000088 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000174 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000964 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000932 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000846 Mitochondrial Matrix/Stoichiometry/1.0
right: Fumaric acid
right: FADH
right: QH2
spontaneous: false
EC number: 1.3.5.1
left: Succinic acid
left: FAD
left: Coenzyme Q10
name: Coenzyme Q10 + FAD + Succinic acid ↔ FADH + Fumaric acid + QH2
conversion direction: REVERSIBLE

Reference/ChEBI CHEBI 422
type: UnificationXref
id: CHEBI:422
db: ChEBI

Reference/ChEBI CHEBI 30744
type: UnificationXref
id: CHEBI:30744
db: ChEBI

Dihydrolipoyl dehydrogenase, mitochondrial
type: ProteinReference
xref: Reference/UniProt D3YT81
organism: Caenorhabditis elegans

ReactionCatalysis139656
type: Catalysis
controller: 6-phosphofructokinase, liver type
controlled: 2.7.1.11
control type: ACTIVATION

Probable citrate synthase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P34575
organism: Caenorhabditis elegans

Reference/PubChem-compound 5793
type: UnificationXref
id: 5793
db: PubChem-compound

Protein/14865 Mitochondrial Matrix/Stoichiometry/2.0
type: Stoichiometry
physical entity: Probable citrate synthase, mitochondrial
stoichiometric coefficient: 2.0

L-Glutamine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Glutamine

Reference/UniProt P53589
type: UnificationXref
id: P53589
db: UniProt

ReactionCatalysis139653
type: Catalysis
controller: Fructose-bisphosphate aldolase 1
controlled: 4.1.2.13
control type: ACTIVATION

ChemicalStructure/PW C000869
type: ChemicalStructure
structure format: SMILES
structure data: OC(COP(O)(O)=O)C=O

ReactionCatalysis139659
type: Catalysis
controller: Glucose-6-phosphate isomerase
controlled: 5.3.1.9
control type: ACTIVATION

Pyruvate dehydrogenase complex
type: Complex
component stoichiometry: Protein/14850 Mitochondrial Matrix/Stoichiometry/60.0
component stoichiometry: Protein/14858 Mitochondrial Matrix/Stoichiometry/24.0
component stoichiometry: Protein/14845 Mitochondrial Matrix/Stoichiometry/60.0
component stoichiometry: Protein/14854 Mitochondrial Matrix/Stoichiometry/60.0
cellular location: Mitochondrial Matrix
component: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
component: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
component: Dihydrolipoyl dehydrogenase, mitochondrial
component: Probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

Reference/PubChem-compound 1198
type: UnificationXref
id: 1198
db: PubChem-compound

Reference/BioCyc FAD
type: UnificationXref
id: FAD
db: BioCyc

ReactionCatalysis139650
type: Catalysis
controller: Transaldolase
controlled: 2.2.1.2
control type: ACTIVATION

Protein/14845 Mitochondrial Matrix/Stoichiometry/60.0
type: Stoichiometry
physical entity: Probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial
stoichiometric coefficient: 60.0

Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q23629
organism: Caenorhabditis elegans

Reference/BioCyc 3-METHYLBENZYLSUCCINYL-COA
type: UnificationXref
id: 3-METHYLBENZYLSUCCINYL-COA
db: BioCyc

Reference/CAS 86-01-1
type: UnificationXref
id: 86-01-1
db: CAS

ReactionCatalysis139424
type: Catalysis
controller: Unknown
controlled: 1.1.1.27
control type: ACTIVATION

Reference/UniProt P53596
type: UnificationXref
id: P53596
db: UniProt

Probable isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q93353
organism: Caenorhabditis elegans

Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q93714
organism: Caenorhabditis elegans

Compound/PW C000164 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 1.0

Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

Reference/ChemSpider 109096
type: UnificationXref
id: 109096
db: ChemSpider

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

Reference/UniProt O17759
type: UnificationXref
id: O17759
db: UniProt

Transport8223
type: Transport
participant stoichiometry: Compound/PW C000063 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000063 Cytosol/Stoichiometry/1.0
right: Citric acid
spontaneous: false
left: Citric acid
name: Citric acid (←) Transport: Caenorhabditis elegans, Cell, Cytosol to Caenorhabditis elegans, Cell, Mitochondrial Matrix
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000881
type: ChemicalStructure
structure format: SMILES

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

6-phosphogluconate dehydrogenase, decarboxylating
type: Protein
cellular location: Cytosol
entity reference: 6-phosphogluconate dehydrogenase, decarboxylating

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

Transaldolase
type: Protein
cellular location: Cytosol
entity reference: Transaldolase

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Malate dehydrogenase
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Malate dehydrogenase

Reference/KEGG Compound C00311
type: UnificationXref
id: C00311
db: KEGG Compound

Reference/ChEBI CHEBI 16134
type: UnificationXref
id: CHEBI:16134
db: ChEBI

Reference/PubChem-compound 439278
type: UnificationXref
id: 439278
db: PubChem-compound

Reference/CAS 110-17-8
type: UnificationXref
id: 110-17-8
db: CAS

Reference/HMDB HMDB0000094
type: UnificationXref
id: HMDB0000094
db: HMDB

Reference/CAS 2641-81-8
type: UnificationXref
id: 2641-81-8
db: CAS

Compound/PW C000101 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Malic acid
stoichiometric coefficient: 1.0

3.5.1.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Mitochondrial Matrix/Stoichiometry/1.0
right: Ammonia
right: L-Glutamic acid
spontaneous: false
EC number: 3.5.1.2
left: L-Glutamine
left: Water
name: L-Glutamine + Water → Ammonia + L-Glutamic acid
conversion direction: LEFT_TO_RIGHT

Protein/14858 Mitochondrial Matrix/Stoichiometry/2.0
type: Stoichiometry
physical entity: Dihydrolipoyl dehydrogenase, mitochondrial
stoichiometric coefficient: 2.0

Reference/UniProt O17732
type: UnificationXref
id: O17732
db: UniProt

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/HMDB HMDB0001197
type: UnificationXref
id: HMDB0001197
db: HMDB

1.4.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Mitochondrial Matrix/Stoichiometry/1.0
right: Ammonia
right: Oxoglutaric acid
right: NADH
spontaneous: false
EC number: 1.4.1.3
left: Water
left: L-Glutamic acid
left: NAD
name: L-Glutamic acid + NAD + Water → Ammonia + NADH + Oxoglutaric acid
conversion direction: LEFT_TO_RIGHT

Probable aconitate hydratase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Probable aconitate hydratase, mitochondrial

Reference/ChemSpider 388330
type: UnificationXref
id: 388330
db: ChemSpider

Reference/CAS 2280-44-6
type: UnificationXref
id: 2280-44-6
db: CAS

Citrate synthase, mitochondrial
type: Complex
component stoichiometry: Protein/14865 Mitochondrial Matrix/Stoichiometry/2.0
cellular location: Mitochondrial Matrix
component: Probable citrate synthase, mitochondrial

Reference/BioCyc ALPHA-GLUCOSE-16-BISPHOSPHATE
type: UnificationXref
id: ALPHA-GLUCOSE-16-BISPHOSPHATE
db: BioCyc

Protein/14913 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5281915
type: UnificationXref
id: 5281915
db: PubChem-compound

Reference/UniProt Q23629
type: UnificationXref
id: Q23629
db: UniProt

FADH
type: SmallMoleculeReference
xref: Reference/PubChem-compound 446013
xref: Reference/ChEBI CHEBI 17877
xref: Reference/BioCyc FADH2
xref: Reference/KEGG Compound C01352
xref: Reference/ChemSpider 393487
xref: Reference/HMDB HMDB0001197
xref: Reference/CAS 1910-41-4
chemical formula: C27H35N9O15P2
molecular weight: 787.1728
structure: ChemicalStructure/PW C000932

Reference/HMDB HMDB0003391
type: UnificationXref
id: HMDB0003391
db: HMDB

Carbon dioxide
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Carbon dioxide

Reference/ChemSpider 709
type: UnificationXref
id: 709
db: ChemSpider

Reference/UniProt Q23621
type: UnificationXref
id: Q23621
db: UniProt

Reference/ChemSpider 704
type: UnificationXref
id: 704
db: ChemSpider

Protein/17161 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Transaldolase
stoichiometric coefficient: 2.0

Reference/ChemSpider 945
type: UnificationXref
id: 945
db: ChemSpider

Reference/KEGG Compound C00345
type: UnificationXref
id: C00345
db: KEGG Compound

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Guanosine diphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001201
xref: Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
xref: Reference/CAS 146-91-8
xref: Reference/PubChem-compound 8977
xref: Reference/ChEBI CHEBI 17552
xref: Reference/ChemSpider 8630
xref: Reference/KEGG Compound C00035
chemical formula: C10H15N5O11P2
molecular weight: 443.02432
structure: ChemicalStructure/PW C000936

Reference/UniProt Q22772
type: UnificationXref
id: Q22772
db: UniProt

Reference/CAS 488-69-7
type: UnificationXref
id: 488-69-7
db: CAS

Reference/ChEBI CHEBI 30887
type: UnificationXref
id: CHEBI:30887
db: ChEBI

Reference/KEGG Compound C00117
type: UnificationXref
id: C00117
db: KEGG Compound

Reference/ChemSpider 388313
type: UnificationXref
id: 388313
db: ChemSpider

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Guanosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15996
xref: Reference/ChemSpider 6569
xref: Reference/KEGG Compound C00044
xref: Reference/PubChem-compound 6830
xref: Reference/HMDB HMDB0001273
xref: Reference/CAS 86-01-1
xref: Reference/BioCyc GTP
chemical formula: C10H16N5O14P3
molecular weight: 522.99066
structure: ChemicalStructure/PW C000986

Protein/14888 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
stoichiometric coefficient: 1.0

Compound/PW C000843 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Sedoheptulose 7-phosphate
stoichiometric coefficient: 1.0

Compound/PW C000146 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

L-Glutamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000641
xref: Reference/ChEBI CHEBI 18050
xref: Reference/ChemSpider 5746
xref: Reference/BioCyc GLN
xref: Reference/KEGG Compound C00064
xref: Reference/PubChem-compound 5961
xref: Reference/CAS 56-85-9
chemical formula: C5H10N2O3
molecular weight: 146.06914
structure: ChemicalStructure/PW C000500

Reference/BioCyc CPD-2961
type: UnificationXref
id: CPD-2961
db: BioCyc

Glyceric acid 1,3-biphosphate
type: SmallMoleculeReference
xref: Reference/CAS 1981-49-3
xref: Reference/ChemSpider 663
xref: Reference/BioCyc DPG
xref: Reference/HMDB HMDB0001270
xref: Reference/KEGG Compound C00236
xref: Reference/PubChem-compound 683
chemical formula: C3H8O10P2
molecular weight: 265.95926
structure: ChemicalStructure/PW C000983

Reference/ChemSpider 388559
type: UnificationXref
id: 388559
db: ChemSpider

Reference/KEGG Compound C00111
type: UnificationXref
id: C00111
db: KEGG Compound

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/KEGG Compound C00597
type: UnificationXref
id: C00597
db: KEGG Compound

Reference/KEGG Compound C00354
type: UnificationXref
id: C00354
db: KEGG Compound

Transport8294
type: Transport
participant stoichiometry: Compound/PW C000077 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000077 Extracellular Space/Stoichiometry/1.0
right: D-Glucose
spontaneous: false
left: D-Glucose
name: D-Glucose (↔) Transport: Caenorhabditis elegans, Extracellular Space to Caenorhabditis elegans, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport8295
type: Transport
participant stoichiometry: Compound/PW C000122 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000122 Extracellular Space/Stoichiometry/1.0
right: L-Lactic acid
spontaneous: false
left: L-Lactic acid
name: L-Lactic acid (→) Transport: Caenorhabditis elegans, Cell, Cytosol to Caenorhabditis elegans, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Probable cytoplasmic aconitate hydratase
type: Protein
cellular location: Cytosol
entity reference: Probable cytoplasmic aconitate hydratase

Transport8296
type: Transport
participant stoichiometry: Compound/PW C000500 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500 Mitochondrial Matrix/Stoichiometry/1.0
right: L-Glutamine
spontaneous: false
left: L-Glutamine
name: L-Glutamine (→) Transport: Caenorhabditis elegans, Cell, Cytosol to Caenorhabditis elegans, Cell, Mitochondrial Matrix
conversion direction: LEFT_TO_RIGHT

Transport8297
type: Transport
participant stoichiometry: Compound/PW C000500 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500 Cytoplasm/Stoichiometry/1.0
right: L-Glutamine
spontaneous: false
left: L-Glutamine
name: L-Glutamine (→) Transport: Caenorhabditis elegans, Extracellular Space to Caenorhabditis elegans, Cell, Cytoplasm
conversion direction: LEFT_TO_RIGHT

Compound/PW C000134 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxoglutaric acid
stoichiometric coefficient: 1.0

Fructose 1,6-bisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Fructose 1,6-bisphosphate

Compound/PW C000077 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glucose
stoichiometric coefficient: 1.0

Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/ChemSpider 559059
type: UnificationXref
id: 559059
db: ChemSpider

Reference/KEGG Compound C00122
type: UnificationXref
id: C00122
db: KEGG Compound

ChemicalStructure/PW C000932
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 122357
type: UnificationXref
id: 122357
db: PubChem-compound

Reference/CAS 921-62-0
type: UnificationXref
id: 921-62-0
db: CAS

NADH
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: NADH

ChemicalStructure/PW C000936
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/CAS 1910-41-4
type: UnificationXref
id: 1910-41-4
db: CAS

Reference/ChemSpider 1031
type: UnificationXref
id: 1031
db: ChemSpider

Probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

Pyruvic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyruvic acid

FAD
type: SmallMoleculeReference
xref: Reference/CAS 146-14-5
xref: Reference/HMDB HMDB0001248
xref: Reference/ChEBI CHEBI 16238
xref: Reference/BioCyc FAD
xref: Reference/PubChem-compound 643975
xref: Reference/ChemSpider 559059
xref: Reference/KEGG Compound C00016
chemical formula: C27H33N9O15P2
molecular weight: 785.1571
structure: ChemicalStructure/PW C000964

Reference/ChemSpider 388538
type: UnificationXref
id: 388538
db: ChemSpider

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H28N7O14P2
molecular weight: 664.11694
structure: ChemicalStructure/PW C000721

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

TransKeTolase homolog
type: Protein
cellular location: Cytosol
entity reference: TransKeTolase homolog

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Glucose-6-phosphate 1-dehydrogenase
type: Complex
component stoichiometry: Protein/17131 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Glucose-6-phosphate 1-dehydrogenase

Reference/UniProt Q93714
type: UnificationXref
id: Q93714
db: UniProt

Reference/KEGG Compound C00149
type: UnificationXref
id: C00149
db: KEGG Compound

Reference/ChemSpider 388307
type: UnificationXref
id: 388307
db: ChemSpider

Reference/UniProt Q8I4F9
type: UnificationXref
id: Q8I4F9
db: UniProt

Reference/KEGG Compound C01236
type: UnificationXref
id: C01236
db: KEGG Compound

Reference/ChemSpider 62713
type: UnificationXref
id: 62713
db: ChemSpider

Fumaric acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Fumaric acid

Reference/UniProt P17330
type: UnificationXref
id: P17330
db: UniProt

Reference/KEGG Compound C00390
type: UnificationXref
id: C00390
db: KEGG Compound

Compound/PW C001191 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Ribose 5-phosphate
stoichiometric coefficient: 1.0

Protein/14928 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Putative succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
stoichiometric coefficient: 1.0

Excitatory amino acid transporter
type: Protein
entity reference: Excitatory amino acid transporter

Reference/CAS 56275-39-9
type: UnificationXref
id: 56275-39-9
db: CAS

Reference/KEGG Compound C00158
type: UnificationXref
id: C00158
db: KEGG Compound

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/CAS 328-50-7
type: UnificationXref
id: 328-50-7
db: CAS

Reference/HMDB HMDB0000254
type: UnificationXref
id: HMDB0000254
db: HMDB

Phosphotransferase
type: Protein
cellular location: Cytosol
entity reference: Phosphotransferase

L-Lactic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Lactic acid

D-Glucose
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Glucose

L-Lactic acid
type: SmallMolecule
cellular location: Extracellular Space
entity reference: L-Lactic acid

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Compound/PW C001104 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Putative glutaminase 2
type: ProteinReference
xref: Reference/UniProt Q19013
organism: Caenorhabditis elegans

Reference/ChemSpider 4445197
type: UnificationXref
id: 4445197
db: ChemSpider

Reference/CAS 303-98-0
type: UnificationXref
id: 303-98-0
db: CAS

Reference/HMDB HMDB0001112
type: UnificationXref
id: HMDB0001112
db: HMDB

Facilitated glucose transporter protein 1
type: Protein
entity reference: Facilitated glucose transporter protein 1

Enolase
type: ProteinReference
xref: Reference/UniProt Q8I4F9
organism: Caenorhabditis elegans

ChemicalStructure/PW C000063
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC(O)(CC(O)=O)C(O)=O

Reference/ChemSpider 762
type: UnificationXref
id: 762
db: ChemSpider

Reference/BioCyc PHOSPHO-ENOL-PYRUVATE
type: UnificationXref
id: PHOSPHO-ENOL-PYRUVATE
db: BioCyc

Protein/15680 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Glyceraldehyde-3-phosphate dehydrogenase 3
stoichiometric coefficient: 4.0

Pyruvate kinase
type: ProteinReference
xref: Reference/UniProt Q3S1I8
organism: Caenorhabditis elegans

Unknown
type: ProteinReference
organism: Caenorhabditis elegans

Reference/HMDB HMDB0000263
type: UnificationXref
id: HMDB0000263
db: HMDB

4.2.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000063 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000125 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000125 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000063 Cytosol/Stoichiometry/1.0
right: Isocitric acid
spontaneous: false
EC number: 4.2.1.3
left: Citric acid
name: Citric acid → Isocitric acid
conversion direction: LEFT_TO_RIGHT

Succinyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Succinyl-CoA

Reference/ChemSpider 10197150
type: UnificationXref
id: 10197150
db: ChemSpider

3.1.1.31
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001015 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000881 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001051 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: Hydrogen
right: 6-Phosphogluconic acid
spontaneous: false
EC number: 3.1.1.31
left: 6-Phosphonoglucono-D-lactone
left: Water
name: 6-Phosphonoglucono-D-lactone + Water → 6-Phosphogluconic acid + Hydrogen
conversion direction: LEFT_TO_RIGHT

1.1.1.49
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001906 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000881 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
right: 6-Phosphonoglucono-D-lactone
right: Hydrogen Ion
right: NADPH
spontaneous: false
EC number: 1.1.1.49
left: β-D-Glucose 6-phosphate
left: NADP
name: NADP + β-D-Glucose 6-phosphate ↔ 6-Phosphonoglucono-D-lactone + Hydrogen Ion + NADPH
conversion direction: REVERSIBLE

1.1.1.42
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000134 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000125 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
right: Oxoglutaric acid
right: Carbon dioxide
right: NADPH
spontaneous: false
EC number: 1.1.1.42
left: Isocitric acid
left: NADP
name: Isocitric acid + NADP → Carbon dioxide + NADPH + Oxoglutaric acid
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 668
type: UnificationXref
id: 668
db: PubChem-compound

Ammonia
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Ammonia

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/CAS 591-59-3
type: UnificationXref
id: 591-59-3
db: CAS

SubPathwayControl109097
type: Interaction
name: SubPathway109097Control
name: InhibitorySubPathwayControl
participant: Tyrosine kinase regulation
participant: Pyruvate kinase PKM
participant: Pyruvate kinase PKLR

Reference/PubChem-compound 22833559
type: UnificationXref
id: 22833559
db: PubChem-compound

Reference/HMDB HMDB0001127
type: UnificationXref
id: HMDB0001127
db: HMDB

Reference/BioCyc AMMONIA
type: UnificationXref
id: AMMONIA
db: BioCyc

ChemicalStructure/PW C000035
type: ChemicalStructure
structure format: SMILES
structure data: N

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

Reference/CAS 585-18-2
type: UnificationXref
id: 585-18-2
db: CAS

Reference/HMDB HMDB0001362
type: UnificationXref
id: HMDB0001362
db: HMDB

NAD
type: SmallMolecule
cellular location: Cytosol
entity reference: NAD

Protein/14918 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
stoichiometric coefficient: 1.0

MonoCarboxylate Transporter family
type: Protein
entity reference: MonoCarboxylate Transporter family

Reference/KEGG Compound C00186
type: UnificationXref
id: C00186
db: KEGG Compound

Reference/ChemSpider 305
type: UnificationXref
id: 305
db: ChemSpider

Reference/PubChem-compound 445557
type: UnificationXref
id: 445557
db: PubChem-compound

2-Phospho-D-glyceric acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 439278
xref: Reference/ChemSpider 388411
xref: Reference/ChEBI CHEBI 17835
xref: Reference/HMDB HMDB0003391
xref: Reference/BioCyc 2-PG
xref: Reference/KEGG Compound C00631
chemical formula: C3H7O7P
molecular weight: 185.99294
structure: ChemicalStructure/PW C001870

Reference/ChEBI CHEBI 17050
type: UnificationXref
id: CHEBI:17050
db: ChEBI

ChemicalStructure/PW C001134
type: ChemicalStructure
structure format: SMILES
structure data: OCC(=O)COP(O)(O)=O

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Reference/BioCyc RIBULOSE-5P
type: UnificationXref
id: RIBULOSE-5P
db: BioCyc

Reference/KEGG Compound C00199
type: UnificationXref
id: C00199
db: KEGG Compound

Reference/ChemSpider 979
type: UnificationXref
id: 979
db: ChemSpider

QH2
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: QH2

Water
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Water

Phosphoric acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/ChEBI CHEBI 26078
xref: Reference/CAS 7664-38-2
xref: Reference/PubChem-compound 1004
xref: Reference/ChemSpider 979
xref: Reference/HMDB HMDB0002142
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001441

Isocitrate dehydrogenase [NADP]
type: ProteinReference
xref: Reference/UniProt H9G2T4
organism: Caenorhabditis elegans

Putative succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Putative succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

Protein/14897 Mitochondrial Matrix/Stoichiometry/4.0
type: Stoichiometry
physical entity: Probable fumarate hydratase, mitochondrial
stoichiometric coefficient: 4.0

Reference/HMDB HMDB0000051
type: UnificationXref
id: HMDB0000051
db: HMDB

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Probable citrate synthase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Probable citrate synthase, mitochondrial

Malate dehydrogenase
type: ProteinReference
xref: Reference/UniProt Q9UAV5
organism: Caenorhabditis elegans

Reference/CAS 146-14-5
type: UnificationXref
id: 146-14-5
db: CAS

Reference/ChEBI CHEBI 44897
type: UnificationXref
id: CHEBI:44897
db: ChEBI

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

Reference/BioCyc GTP
type: UnificationXref
id: GTP
db: BioCyc

Reference/BioCyc RIBOSE-5P
type: UnificationXref
id: RIBOSE-5P
db: BioCyc

Facilitated glucose transporter protein 1
type: ProteinReference
xref: Reference/UniProt H2L0B9

ChemicalStructure/PW C001191
type: ChemicalStructure
structure format: SMILES
structure data: OC1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O

L-Lactic acid
type: SmallMoleculeReference
xref: Reference/CAS 79-33-4
xref: Reference/ChEBI CHEBI 422
xref: Reference/HMDB HMDB0000190
xref: Reference/PubChem-compound 107689
xref: Reference/KEGG Compound C00186
xref: Reference/BioCyc L-LACTATE
xref: Reference/ChemSpider 96860
chemical formula: C3H6O3
molecular weight: 90.03169
structure: ChemicalStructure/PW C000122

Transketolase
type: Complex
component stoichiometry: Protein/17156 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: TransKeTolase homolog

Excitatory amino acid transporter
type: ProteinReference
xref: Reference/UniProt Q17920

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

Reference/CAS 56-73-5
type: UnificationXref
id: 56-73-5
db: CAS

Reference/BioCyc 2-PG
type: UnificationXref
id: 2-PG
db: BioCyc

Reference/UniProt Q9UAV5
type: UnificationXref
id: Q9UAV5
db: UniProt

ChemicalStructure/PW C000077
type: ChemicalStructure
structure format: SMILES
structure data: OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O

Compound/PW C001441 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoric acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Pyruvate carboxylase 1
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Pyruvate carboxylase 1

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

ChemicalStructure/PW C000079
type: ChemicalStructure
structure format: SMILES

Hydrogen carbonate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Hydrogen carbonate

6-phosphogluconate dehydrogenase, decarboxylating
type: Complex
component stoichiometry: Protein/17662 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: 6-phosphogluconate dehydrogenase, decarboxylating

Glucose-6-phosphate isomerase
type: ProteinReference
xref: Reference/UniProt Q9U1Q2
organism: Caenorhabditis elegans

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Compound/PW C001316 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/ChemSpider 749
type: UnificationXref
id: 749
db: ChemSpider

Reference/CAS 71-52-3
type: UnificationXref
id: 71-52-3
db: CAS

ChemicalStructure/PW C000088
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)\C=C\C(O)=O

Reference/ChemSpider 980
type: UnificationXref
id: 980
db: ChemSpider

Reference/CAS 146-91-8
type: UnificationXref
id: 146-91-8
db: CAS

L-Malic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000156
xref: Reference/ChEBI CHEBI 30797
xref: Reference/KEGG Compound C00149
xref: Reference/ChemSpider 193317
xref: Reference/PubChem-compound 222656
xref: Reference/CAS 97-67-6
chemical formula: C4H6O5
molecular weight: 134.02153
structure: ChemicalStructure/PW C000101

2-Phospho-D-glyceric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: 2-Phospho-D-glyceric acid

Compound/PW C001134 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydroxyacetone phosphate
stoichiometric coefficient: 1.0

Oxalacetic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000223
xref: Reference/CAS 328-42-7
xref: Reference/ChEBI CHEBI 30744
xref: Reference/BioCyc OXALACETIC ACID
xref: Reference/ChemSpider 945
xref: Reference/PubChem-compound 970
xref: Reference/KEGG Compound C00036
chemical formula: C4H4O5
molecular weight: 132.00587
structure: ChemicalStructure/PW C000148

Adenosine triphosphate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Adenosine triphosphate

Compound/PW C000983 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glyceric acid 1,3-biphosphate
stoichiometric coefficient: 1.0

Compound/PW C000833 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fructose 1,6-bisphosphate
stoichiometric coefficient: 1.0

Probable phosphoglycerate kinase
type: Protein
cellular location: Cytosol
entity reference: Probable phosphoglycerate kinase

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/BioCyc CIT
type: UnificationXref
id: CIT
db: BioCyc

Reference/PubChem-compound 58838673
type: UnificationXref
id: 58838673
db: PubChem-compound

Protein/15630 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: ATP-dependent 6-phosphofructokinase 1
stoichiometric coefficient: 4.0

Reference/UniProt Q34089
type: UnificationXref
id: Q34089
db: UniProt

Protein/15102 Mitochondrial Matrix/Stoichiometry/6.0
type: Stoichiometry
physical entity: Glutamate dehydrogenase
stoichiometric coefficient: 6.0

QH2
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001304
xref: Reference/BioCyc QH2
xref: Reference/PubChem-compound 5280344
xref: Reference/KEGG Compound C00390
xref: Reference/CAS 56275-39-9
xref: Reference/ChemSpider 4444052
chemical formula: (C5H8)nC14H20O4
structure: ChemicalStructure/PW C001006

Reference/PubChem-compound 1004
type: UnificationXref
id: 1004
db: PubChem-compound

Reference/PubChem-compound 1005
type: UnificationXref
id: 1005
db: PubChem-compound

Compound/PW C000143 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Reference/CAS 328-42-7
type: UnificationXref
id: 328-42-7
db: CAS

ChemicalStructure/PW C000101
type: ChemicalStructure
structure format: SMILES
structure data: O[C@@H](CC(O)=O)C(O)=O

6-Phosphogluconic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 48928
xref: Reference/BioCyc CPD-2961
xref: Reference/HMDB HMDB0001316
xref: Reference/CAS 921-62-0
xref: Reference/PubChem-compound 91493
xref: Reference/ChemSpider 82615
xref: Reference/KEGG Compound C00345
chemical formula: C6H13O10P
molecular weight: 276.02463
structure: ChemicalStructure/PW C001015

Compound/PW C000936 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine diphosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/ChEBI CHEBI 16938
type: UnificationXref
id: CHEBI:16938
db: ChEBI

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

6-Phosphogluconic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: 6-Phosphogluconic acid

Pyruvic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 1060
xref: Reference/HMDB HMDB0000243
xref: Reference/CAS 127-17-3
xref: Reference/BioCyc PYRUVATE
xref: Reference/KEGG Compound C00022
xref: Reference/ChEBI CHEBI 32816
xref: Reference/ChemSpider 1031
chemical formula: C3H4O3
molecular weight: 88.016045
structure: ChemicalStructure/PW C000164

6-Phosphonoglucono-D-lactone
type: SmallMolecule
cellular location: Cytosol
entity reference: 6-Phosphonoglucono-D-lactone

Phosphotransferase
type: ProteinReference
xref: Reference/UniProt Q6BET1
organism: Caenorhabditis elegans

Compound/PW C000986 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine triphosphate
stoichiometric coefficient: 1.0

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Isocitric acid
type: SmallMoleculeReference
xref: Reference/CAS 320-77-4
xref: Reference/BioCyc threo-d(s)-iso-citrate
xref: Reference/ChEBI CHEBI 30887
xref: Reference/ChemSpider 1161
xref: Reference/HMDB HMDB0000193
xref: Reference/KEGG Compound C00311
xref: Reference/PubChem-compound 1198
chemical formula: C6H8O7
molecular weight: 192.02701
structure: ChemicalStructure/PW C000125

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Probable phosphoglycerate kinase
type: ProteinReference
xref: Reference/UniProt P91427
organism: Caenorhabditis elegans

Oxoglutaric acid
type: SmallMoleculeReference
xref: Reference/CAS 328-50-7
xref: Reference/PubChem-compound 51
xref: Reference/BioCyc 2-KETOGLUTARATE
xref: Reference/HMDB HMDB0000208
xref: Reference/ChEBI CHEBI 30915
xref: Reference/KEGG Compound C00026
xref: Reference/ChemSpider 50
chemical formula: C5H6O5
molecular weight: 146.02153
structure: ChemicalStructure/PW C000134

Reference/UniProt H2L0B9
type: UnificationXref
id: H2L0B9
db: UniProt

Reference/ChEBI CHEBI 16905
type: UnificationXref
id: CHEBI:16905
db: ChEBI

Reference/ChemSpider 393487
type: UnificationXref
id: 393487
db: ChemSpider

Citric acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Citric acid

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

MonoCarboxylate Transporter family
type: ProteinReference
xref: Reference/UniProt O17328

Isocitrate dehydrogenase [NADP] cytoplasmic
type: Complex
component stoichiometry: Protein/17674 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Isocitrate dehydrogenase [NADP]

Reference/CAS 77-92-9
type: UnificationXref
id: 77-92-9
db: CAS

Compound/PW C000644 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Phosphoglyceric acid
stoichiometric coefficient: 1.0

6-phosphogluconate dehydrogenase, decarboxylating
type: ProteinReference
xref: Reference/UniProt Q22772
organism: Caenorhabditis elegans

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

Reference/BioCyc L-LACTATE
type: UnificationXref
id: L-LACTATE
db: BioCyc

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H29N7O17P3
molecular weight: 744.08325
structure: ChemicalStructure/PW C000143

Probable cytoplasmic aconitate hydratase
type: ProteinReference
xref: Reference/UniProt Q23500
organism: Caenorhabditis elegans

ReactionCatalysis139953
type: Catalysis
controller: Probable aconitate hydratase, mitochondrial
controlled: 4.2.1.3
control type: ACTIVATION

ReactionCatalysis139954
type: Catalysis
controller: Probable cytoplasmic aconitate hydratase
controlled: 4.2.1.3
control type: ACTIVATION

Reference/HMDB HMDB0000208
type: UnificationXref
id: HMDB0000208
db: HMDB

Reference/PubChem-compound 683
type: UnificationXref
id: 683
db: PubChem-compound

Phosphoenolpyruvic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphoenolpyruvic acid

ReactionCatalysis139957
type: Catalysis
controller: Glucose-6-phosphate 1-dehydrogenase
controlled: 1.1.1.49
control type: ACTIVATION

ReactionCatalysis139956
type: Catalysis
controller: Putative 6-phosphogluconolactonase
controlled: 3.1.1.31
control type: ACTIVATION

ReactionCatalysis139959
type: Catalysis
controller: Isocitrate dehydrogenase [NADP] cytoplasmic
controlled: 1.1.1.42
control type: ACTIVATION

Reference/HMDB HMDB0001304
type: UnificationXref
id: HMDB0001304
db: HMDB

ChemicalStructure/PW C000134
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(=O)C(O)=O

Reference/HMDB HMDB0001548
type: UnificationXref
id: HMDB0001548
db: HMDB

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Compound/PW C000500 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamine
stoichiometric coefficient: 1.0

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Guanosine diphosphate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Guanosine diphosphate

Protein/14854 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17835
type: UnificationXref
id: CHEBI:17835
db: ChEBI

Reference/UniProt Q21828
type: UnificationXref
id: Q21828
db: UniProt

Reference/BioCyc GLC
type: UnificationXref
id: GLC
db: BioCyc

Compound/PW C000721 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Pyruvate kinase
type: Protein
cellular location: Cytosol
entity reference: Pyruvate kinase

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Reference/HMDB HMDB0000223
type: UnificationXref
id: HMDB0000223
db: HMDB

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc GLN
type: UnificationXref
id: GLN
db: BioCyc

Reference/HMDB HMDB0001316
type: UnificationXref
id: HMDB0001316
db: HMDB

Hydrogen
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

Reference/CAS 7664-41-7
type: UnificationXref
id: 7664-41-7
db: CAS

Compound/PW C000088 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fumaric acid
stoichiometric coefficient: 1.0

Reference/CAS 57-04-5
type: UnificationXref
id: 57-04-5
db: CAS

Reference/UniProt Q19749
type: UnificationXref
id: Q19749
db: UniProt

Reference/PubChem-compound 69507
type: UnificationXref
id: 69507
db: PubChem-compound

Hydrogen
type: SmallMoleculeReference
xref: Reference/PubChem-compound 58838673
xref: Reference/CAS 1333-74-0
xref: Reference/ChemSpider 762
xref: Reference/BioCyc ALPHA-GLUCOSE-16-BISPHOSPHATE
xref: Reference/KEGG Compound C00282
xref: Reference/HMDB HMDB0001362
xref: Reference/ChEBI CHEBI 18276
chemical formula: H2
molecular weight: 2.01565
structure: ChemicalStructure/PW C001051

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Reference/UniProt H9G2T4
type: UnificationXref
id: H9G2T4
db: UniProt

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

D-Erythrose 4-phosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 48153
xref: Reference/HMDB HMDB0001321
xref: Reference/CAS 585-18-2
xref: Reference/BioCyc ERYTHROSE-4P
xref: Reference/PubChem-compound 122357
xref: Reference/ChemSpider 109096
xref: Reference/KEGG Compound C00279
chemical formula: C4H9O7P
molecular weight: 200.00859
structure: ChemicalStructure/PW C001019

Reference/ChemSpider 4444052
type: UnificationXref
id: 4444052
db: ChemSpider

Reference/PubChem-compound 222
type: UnificationXref
id: 222
db: PubChem-compound

Hydrogen Ion
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Hydrogen Ion

ChemicalStructure/PW C001441
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001321
type: UnificationXref
id: HMDB0001321
db: HMDB

Reference/PubChem-compound 5280344
type: UnificationXref
id: 5280344
db: PubChem-compound

Succinic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000254
xref: Reference/CAS 110-15-6
xref: Reference/ChEBI CHEBI 15741
xref: Reference/KEGG Compound C00042
xref: Reference/ChemSpider 1078
xref: Reference/PubChem-compound 1110
xref: Reference/BioCyc SUC
chemical formula: C4H6O4
molecular weight: 118.02661
structure: ChemicalStructure/PW C000174

Reference/CAS 60802-29-1
type: UnificationXref
id: 60802-29-1
db: CAS

Reference/CAS 320-77-4
type: UnificationXref
id: 320-77-4
db: CAS

Reference/BioCyc threo-d(s)-iso-citrate
type: UnificationXref
id: threo-d(s)-iso-citrate
db: BioCyc

Reference/UniProt P34575
type: UnificationXref
id: P34575
db: UniProt

Reference/BioCyc ERYTHROSE-4P
type: UnificationXref
id: ERYTHROSE-4P
db: BioCyc

Glyceraldehyde-3-phosphate dehydrogenase 3
type: ProteinReference
xref: Reference/UniProt P17330
organism: Caenorhabditis elegans

Reference/PathWhiz PW088546
type: UnificationXref
id: PW088546
db: PathWhiz

Reference/HMDB HMDB0000243
type: UnificationXref
id: HMDB0000243
db: HMDB

Phosphoenolpyruvic acid
type: SmallMoleculeReference
xref: Reference/CAS 138-08-9
xref: Reference/ChEBI CHEBI 44897
xref: Reference/KEGG Compound C00074
xref: Reference/BioCyc PHOSPHO-ENOL-PYRUVATE
xref: Reference/ChemSpider 980
xref: Reference/PubChem-compound 1005
xref: Reference/HMDB HMDB0000263
chemical formula: C3H5O6P
molecular weight: 167.98238
structure: ChemicalStructure/PW C000180

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

ChemicalStructure/PW C000125
type: ChemicalStructure
structure format: SMILES
structure data: OC(C(CC(O)=O)C(O)=O)C(O)=O

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000122
type: ChemicalStructure
structure format: SMILES
structure data: C[C@@H](O)C(O)=O

Reference/CAS 4151-19-3
type: UnificationXref
id: 4151-19-3
db: CAS

D-Glyceraldehyde 3-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Glyceraldehyde 3-phosphate

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

ChemicalStructure/PW C000964
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Reference/PubChem-compound 19782904
type: UnificationXref
id: 19782904
db: PubChem-compound

Reference/HMDB HMDB0000807
type: UnificationXref
id: HMDB0000807
db: HMDB

Dihydroxyacetone phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Dihydroxyacetone phosphate

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

Protein/17662 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: 6-phosphogluconate dehydrogenase, decarboxylating
stoichiometric coefficient: 2.0

Oxalacetic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Oxalacetic acid

Reference/ChemSpider 17216052
type: UnificationXref
id: 17216052
db: ChemSpider

Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

Glucose 6-phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00092
xref: Reference/BioCyc GLC-6-P
xref: Reference/HMDB HMDB0001401
xref: Reference/PubChem-compound 5958
xref: Reference/ChemSpider 5743
xref: Reference/CAS 56-73-5
xref: Reference/ChEBI CHEBI 4170
chemical formula: C6H13O9P
molecular weight: 260.02972
structure: ChemicalStructure/PW C001083

Reference/UniProt Q17920
type: UnificationXref
id: Q17920
db: UniProt

Reference/ChEBI CHEBI 17877
type: UnificationXref
id: CHEBI:17877
db: ChEBI

Reference/UniProt O17214
type: UnificationXref
id: O17214
db: UniProt

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine diphosphate

ChemicalStructure/PW C000983
type: ChemicalStructure
structure format: SMILES
structure data: OC(COP(O)(O)=O)C(=O)OP(O)(O)=O

Caenorhabditis elegans
type: BioSource
xref: Reference/TAXONOMY 6239

Isocitric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Isocitric acid

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Unknown
type: Protein
cellular location: Cytosol
entity reference: Unknown

Reference/PubChem-compound 91493
type: UnificationXref
id: 91493
db: PubChem-compound

Reference/PubChem-compound 439427
type: UnificationXref
id: 439427
db: PubChem-compound

Compound/PW C001906 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: β-D-Glucose 6-phosphate
stoichiometric coefficient: 1.0

Reference/TAXONOMY 6239
type: UnificationXref
id: 6239
db: TAXONOMY

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/ChemSpider 5589
type: UnificationXref
id: 5589
db: ChemSpider

ATP-dependent 6-phosphofructokinase 1
type: ProteinReference
xref: Reference/UniProt Q95X24
organism: Caenorhabditis elegans

Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Compound/PW C001034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Compound/PW C001870 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Phospho-D-glyceric acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 48153
type: UnificationXref
id: CHEBI:48153
db: ChEBI

Reference/CAS 79-33-4
type: UnificationXref
id: 79-33-4
db: CAS

ATP-dependent 6-phosphofructokinase 1
type: Protein
cellular location: Cytosol
entity reference: ATP-dependent 6-phosphofructokinase 1

Reference/PubChem-compound 439452
type: UnificationXref
id: 439452
db: PubChem-compound

Compound/PW C000500 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamine
stoichiometric coefficient: 1.0

Reference/BioCyc FRUCTOSE-16-DIPHOSPHATE
type: UnificationXref
id: FRUCTOSE-16-DIPHOSPHATE
db: BioCyc

Fructose-bisphosphate aldolase 1
type: ProteinReference
xref: Reference/UniProt O45747
organism: Caenorhabditis elegans

Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Reference/PubChem-compound 8977
type: UnificationXref
id: 8977
db: PubChem-compound

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Glucose-6-phosphate isomerase
type: Protein
cellular location: Cytosol
entity reference: Glucose-6-phosphate isomerase

Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

Transport8147
type: Transport
participant stoichiometry: Compound/PW C000164 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Mitochondrial Matrix/Stoichiometry/1.0
right: Pyruvic acid
spontaneous: false
left: Pyruvic acid
name: Pyruvic acid (→) Transport: Caenorhabditis elegans, Cell, Cytosol to Caenorhabditis elegans, Cell, Mitochondrial Matrix
conversion direction: LEFT_TO_RIGHT

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Compound/PW C000079 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fructose 6-phosphate
stoichiometric coefficient: 1.0

Glucose 6-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Glucose 6-phosphate

Probable mitochondrial pyruvate carrier 1
type: Protein
entity reference: Probable mitochondrial pyruvate carrier 1

Compound/PW C000964 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: FAD
stoichiometric coefficient: 1.0

Oxoglutaric acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Oxoglutaric acid

ReactionCatalysis139318
type: Catalysis
controller: Glyceraldehyde-3-phosphate dehydrogenase
controlled: Reaction148931
control type: ACTIVATION

Reference/KEGG Compound C00631
type: UnificationXref
id: C00631
db: KEGG Compound

Reference/ChemSpider 8630
type: UnificationXref
id: 8630
db: ChemSpider

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/ChEBI CHEBI 16332
type: UnificationXref
id: CHEBI:16332
db: ChEBI

Reference/ChEBI CHEBI 32816
type: UnificationXref
id: CHEBI:32816
db: ChEBI

Succinyl-CoA ligase
type: Complex
component stoichiometry: Protein/14892 Mitochondrial Matrix/Stoichiometry/1.0
component stoichiometry: Protein/14888 Mitochondrial Matrix/Stoichiometry/1.0
cellular location: Mitochondrial Matrix
component: Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial
component: Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

Reference/UniProt Q95X24
type: UnificationXref
id: Q95X24
db: UniProt

Xylulose 5-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Xylulose 5-phosphate

Reference/ChEBI CHEBI 16108
type: UnificationXref
id: CHEBI:16108
db: ChEBI

Reaction148931
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001441 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000983 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000869 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytosol/Stoichiometry/1.0
right: NADH
right: Glyceric acid 1,3-biphosphate
spontaneous: false
left: NAD
left: Phosphoric acid
left: D-Glyceraldehyde 3-phosphate
name: D-Glyceraldehyde 3-phosphate + NAD + Phosphoric acid ↔ Glyceric acid 1,3-biphosphate + NADH
conversion direction: REVERSIBLE

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Glyceric acid 1,3-biphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Glyceric acid 1,3-biphosphate

Reference/HMDB HMDB0000618
type: UnificationXref
id: HMDB0000618
db: HMDB

ChemicalStructure/PW C001870
type: ChemicalStructure
structure format: SMILES
structure data: OC[C@@H](OP(O)(O)=O)C(O)=O

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Glucose-6-phosphate 1-dehydrogenase
type: Protein
cellular location: Cytosol
entity reference: Glucose-6-phosphate 1-dehydrogenase

Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial

Reference/HMDB HMDB0000868
type: UnificationXref
id: HMDB0000868
db: HMDB

ChemicalStructure/PW C000986
type: ChemicalStructure
structure format: SMILES

Fructose-bisphosphate aldolase 1
type: Protein
cellular location: Cytosol
entity reference: Fructose-bisphosphate aldolase 1

ChemicalStructure/PW C000500
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(N)=O)C(O)=O

Citric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Citric acid

Reference/ChemSpider 193317
type: UnificationXref
id: 193317
db: ChemSpider

Reference/BioCyc GAP
type: UnificationXref
id: GAP
db: BioCyc

Reference/PubChem-compound 1060
type: UnificationXref
id: 1060
db: PubChem-compound

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Protein/14873 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Probable isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00661
type: UnificationXref
id: C00661
db: KEGG Compound

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/HMDB HMDB0000641
type: UnificationXref
id: HMDB0000641
db: HMDB

Reference/BioCyc UBIQUINONE-10
type: UnificationXref
id: UBIQUINONE-10
db: BioCyc

Reference/CAS 4300-28-1
type: UnificationXref
id: 4300-28-1
db: CAS