Guanine
nucleotide-
binding protein
G(I)/G(S)/G(O)
subunit gamma-2
Guanine
nucleotide-
binding protein
G(I)/G(S)/G(T)
subunit beta-1
Phospholipase
C, beta 1
Inositol 1,4,5-
trisphosphate
receptor type 1
protein kinase
C beta
NF-kappa-B
inhibitor zeta
Guanine
nucleotide-
binding protein
G(I)/G(S)/G(O)
subunit gamma-2
Histamine H1
receptor
Gαq
Gαq
Histamine H1
receptor
Guanine
nucleotide-
binding protein
G(I)/G(S)/G(T)
subunit beta-1
Histamine
Inositol 1,4,5-
trisphosphate
Ca+
Ca+
H2O
Calcium
Calcium
GDP
GTP
Histamine
1,2-diacyl-
sn-glycerol
phosphatidylinositol
4,5-
bisphosphate
↑ Pro-inflammatory
Cytokines, Cell Adhesion
Molecules, Chemotactic
Factors
Mast Cells
Release
Histamine
Endoplasmic Reticulum
Nucleus
Calcium Ion Channel
Cell Membrane
Cytoplasm
↑ Antigen Presentation
↑ Mediator Release
↓ Mast Cell Stabilization