Guanosine diphosphate
C04637
KEGG Compound
1.0
Endoplasmic Reticulum
A5D7N0
UniProt
937
ChemSpider
Inositol 1,4,5-trisphosphate
51-45-6
CAS
C01245
KEGG Compound
C00035
KEGG Compound
SMILES
NCCC1=CNC=N1
Mast Cells Release Histamine
SubPathway
direct_interaction
1,2-diacyl-sn-glycerol
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Histamine
SubPathwayOutput
SMILES
O
Calcium
Inositol 1,4,5-trisphosphate receptor type 1
PW109043
PathWhiz
9913
TAXONOMY
Inositol 1,4,5-trisphosphate receptor type 1
Q3MHF1
UniProt
Histamine H1 receptor
C00044
KEGG Compound
Water
Histamine H1 receptor (Bos taurus)_Gαq (Bos taurus)_Guanosine diphosphate_Gβγ (Bos taurus)
1.0
SMILES
O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O
Gβγ
Bos taurus
Q7M2U0
UniProt
Cytoplasm
Guanine nucleotide-binding protein subunit alpha-11
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
1.0
4.0
7732-18-5
CAS
CHEBI:16595
ChEBI
439456
PubChem-compound
85166-31-0
CAS
GO:0005783
GENE ONTOLOGY
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Histamine H1 receptor
774
PubChem-compound
SMP0108002
SMPDB
8977
PubChem-compound
Inositol 1,4,5-trisphosphate
6830
PubChem-compound
Inositol 1,4,5-trisphosphate receptor type 1
C10H15N5O11P2
Guanosine diphosphate
443.02432
HMDB0001498
HMDB
266
ChemSpider
Protein kinase C beta type
1.0
A7Z059
UniProt
962
PubChem-compound
Guanosine triphosphate_Gαq (Bos taurus)
C10H16N5O14P3
Guanosine triphosphate
522.99066
NF-kappa-B inhibitor zeta
Guanosine triphosphate
C00076
KEGG Compound
8630
ChemSpider
1.0
Inositol 1,4,5-trisphosphate receptor type 1
CA%2b2
BioCyc
Transport9387
false
Calcium (→) Transport: Bos taurus, Cell, Endoplasmic Reticulum to Bos taurus, Cell, Cytoplasm
LEFT_TO_RIGHT
Q2TA47
UniProt
GO:0005886
GENE ONTOLOGY
Inositol 1,4,5-trisphosphate receptor type 1
Ca
Calcium
39.96259
Guanine nucleotide-binding protein subunit alpha-11
Histamine
1.0
HMDB0002111
HMDB
inositol_1,4,5-trisphosphate
BioCyc
SubPathwayInteraction109132
SubPathwayReaction
SubPathway109132Reaction
1,2-diacyl-sn-glycerol
Cell Membrane
CHEBI:15377
ChEBI
1.0
6569
ChemSpider
C00001
KEGG Compound
ReactionCatalysis164188
ACTIVATION
HISTAMINE
BioCyc
271
PubChem-compound
CHEBI:17552
ChEBI
SMILES
NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1
GTP
BioCyc
C00641
KEGG Compound
Interaction1112
Guanosine triphosphate + Gαq (Bos taurus) activates Phospholipase C, beta 1
388562
ChemSpider
Interaction1111
Histamine activates Histamine H1 receptor (Bos taurus) + Gαq (Bos taurus) + Guanosine diphosphate + Gβγ (Bos taurus)
HMDB0000464
HMDB
GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
BioCyc
1,2-diacyl-sn-glycerol
GO:0005634
GENE ONTOLOGY
HMDB0001273
HMDB
1.0
1.0
P10894
UniProt
1.0
SMILES
NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1
P30546
UniProt
CHEBI:18295
ChEBI
4.0
HMDB0001201
HMDB
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Interaction1305
1,2-diacyl-sn-glycerol activates protein kinase C beta
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
HMDB0000870
HMDB
753
ChemSpider
Interaction1304
Inositol 1,4,5-trisphosphate activates Inositol 1,4,5-trisphosphate receptor type 1
H2O
Water
18.010565
Interaction1307
protein kinase C beta activates Nuclear factor NF-kappa-B p105 subunit
14127-61-8
CAS
SMILES
[Ca++]
Interaction1306
Calcium activates protein kinase C beta
Protein kinase C beta type
NF-kappa-B inhibitor zeta
C5H9N3
Histamine
111.07965
Reaction173902
false
Water + phosphatidylinositol 4,5-bisphosphate → 1,2-diacyl-sn-glycerol + Inositol 1,4,5-trisphosphate
LEFT_TO_RIGHT
phosphatidylinositol 4,5-bisphosphate
86-01-1
CAS
Reaction173903
false
Histamine H1 receptor (Bos taurus) + Gαq (Bos taurus) + Guanosine diphosphate + Gβγ (Bos taurus) → Guanosine triphosphate + Gαq (Bos taurus) + Gβγ + Histamine + Histamine H1 receptor (Bos taurus)
LEFT_TO_RIGHT
Nucleus
CHEBI:15996
ChEBI
1.0
TransportCatalysis1157
ACTIVATION
Calcium
Histamine_Histamine H1 receptor (Bos taurus)
1.0
Q2KI31
UniProt
1.0
C00388
KEGG Compound
Histamine H1 Receptor Activation
C6H15O15P3
Inositol 1,4,5-trisphosphate
419.96237
1.0
CHEBI:29108
ChEBI
GO:0005737
GENE ONTOLOGY
Protein kinase C beta type
146-91-8
CAS
1.0
phosphatidylinositol 4,5-bisphosphate