Guanosine diphosphate
Inositol 1,4,5-trisphosphate receptor type 1
C04637
KEGG Compound
1.0
Endoplasmic Reticulum
Interaction1165
Histamine activates Histamine H1 receptor (Rattus norvegicus) + Gαq (Rattus norvegicus) + Guanosine diphosphate + Gβγ (Rattus norvegicus)
937
ChemSpider
SMP0108013
SMPDB
10116
TAXONOMY
Inositol 1,4,5-trisphosphate
51-45-6
CAS
Inositol 1,4,5-trisphosphate receptor type 1
Interaction1169
Calcium activates protein kinase C beta
Interaction1168
1,2-diacyl-sn-glycerol activates protein kinase C beta
Interaction1167
Inositol 1,4,5-trisphosphate activates Inositol 1,4,5-trisphosphate receptor type 1
C01245
KEGG Compound
C00035
KEGG Compound
SMILES
NCCC1=CNC=N1
direct_interaction
1,2-diacyl-sn-glycerol
Histamine
SubPathwayOutput
SMILES
O
Calcium
TransportCatalysis1164
ACTIVATION
Reaction173922
false
Water + phosphatidylinositol 4,5-bisphosphate → 1,2-diacyl-sn-glycerol + Inositol 1,4,5-trisphosphate
LEFT_TO_RIGHT
Reaction173923
false
Histamine H1 receptor (Rattus norvegicus) + Gαq (Rattus norvegicus) + Guanosine diphosphate + Gβγ (Rattus norvegicus) → Guanosine triphosphate + Gαq (Rattus norvegicus) + Gβγ + Histamine + Histamine H1 receptor (Rattus norvegicus)
LEFT_TO_RIGHT
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
P10687
UniProt
Inositol 1,4,5-trisphosphate receptor type 1
Guanine nucleotide-binding protein G(q) subunit alpha
C00044
KEGG Compound
Water
1.0
1.0
SMILES
O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O
4.0
Interaction1314
Guanosine triphosphate + Gαq (Rattus norvegicus) activates Phospholipase C, beta 1
Guanosine triphosphate_Gαq (Rattus norvegicus)
4.0
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
Cytoplasm
Guanine nucleotide-binding protein G(q) subunit alpha
1.0
1.0
7732-18-5
CAS
CHEBI:16595
ChEBI
Q62869
UniProt
1.0
P68403
UniProt
Mast Cells Release Histamine
SubPathway
439456
PubChem-compound
Histamine_Histamine H1 receptor (Rattus norvegicus)
P31390
UniProt
85166-31-0
CAS
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
GO:0005783
GENE ONTOLOGY
Inositol 1,4,5-trisphosphate receptor type 1
Histamine H1 receptor
774
PubChem-compound
Interaction1170
protein kinase C beta activates Nuclear factor NF-kappa-B p105 subunit
8977
PubChem-compound
Inositol 1,4,5-trisphosphate
6830
PubChem-compound
C10H15N5O11P2
Guanosine diphosphate
443.02432
P63077
UniProt
HMDB0001498
HMDB
266
ChemSpider
Rattus norvegicus
Protein kinase C beta type
PW109054
PathWhiz
1.0
962
PubChem-compound
Q9QWG8
UniProt
C10H16N5O14P3
Guanosine triphosphate
522.99066
Guanosine triphosphate
C00076
KEGG Compound
8630
ChemSpider
1.0
CA%2b2
BioCyc
GO:0005886
GENE ONTOLOGY
Inositol 1,4,5-trisphosphate receptor type 1
Ca
Calcium
39.96259
Histamine
1.0
HMDB0002111
HMDB
inositol_1,4,5-trisphosphate
BioCyc
1,2-diacyl-sn-glycerol
Histamine H1 receptor (Rattus norvegicus)_Gαq (Rattus norvegicus)_Guanosine diphosphate_Gβγ (Rattus norvegicus)
Cell Membrane
CHEBI:15377
ChEBI
6569
ChemSpider
C00001
KEGG Compound
P82471
UniProt
HISTAMINE
BioCyc
271
PubChem-compound
CHEBI:17552
ChEBI
SMILES
NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
GTP
BioCyc
C00641
KEGG Compound
388562
ChemSpider
HMDB0000464
HMDB
GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
BioCyc
1,2-diacyl-sn-glycerol
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
Nuclear factor NF-kappa-B p105 subunit
GO:0005634
GENE ONTOLOGY
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
HMDB0001273
HMDB
SMILES
NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1
CHEBI:18295
ChEBI
Histamine H1 receptor
Histamine H1 Receptor Activation
HMDB0001201
HMDB
HMDB0000870
HMDB
753
ChemSpider
SubPathwayInteraction109152
SubPathway109152Reaction
SubPathwayReaction
H2O
Water
18.010565
Gβγ
14127-61-8
CAS
SMILES
[Ca++]
C5H9N3
Histamine
111.07965
phosphatidylinositol 4,5-bisphosphate
86-01-1
CAS
Nucleus
Nuclear factor NF-kappa-B p105 subunit
ReactionCatalysis164205
ACTIVATION
CHEBI:15996
ChEBI
Q63369
UniProt
1.0
Calcium
Protein kinase C beta type
Protein kinase C beta type
1.0
1.0
C00388
KEGG Compound
Transport9396
false
Calcium (→) Transport: Rattus norvegicus, Cell, Endoplasmic Reticulum to Rattus norvegicus, Cell, Cytoplasm
LEFT_TO_RIGHT
C6H15O15P3
Inositol 1,4,5-trisphosphate
419.96237
1.0
CHEBI:29108
ChEBI
GO:0005737
GENE ONTOLOGY
146-91-8
CAS
1.0
phosphatidylinositol 4,5-bisphosphate
1.0