Protein/19584 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tyrosine-protein kinase SYK
stoichiometric coefficient: 1.0

Arachidonic acid
type: SmallMoleculeReference
xref: Reference/CAS 506-32-1
xref: Reference/BioCyc ARACHIDONIC ACID
xref: Reference/ChEBI CHEBI 15843
xref: Reference/KEGG Compound C00219
xref: Reference/HMDB HMDB0001043
xref: Reference/ChemSpider 392692
xref: Reference/PubChem-compound 444899
chemical formula: C20H32O2
molecular weight: 304.24023
structure: ChemicalStructure/PW C000821

Reference/ChEBI CHEBI 15843
type: UnificationXref
id: CHEBI:15843
db: ChEBI

GTPase HRas
type: Protein
cellular location: Cytosol
entity reference: GTPase HRas

[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial
type: Complex
component stoichiometry: Protein/19612 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial

Reference/UniProt Q91VX1
type: UnificationXref
id: Q91VX1
db: UniProt

Compound/PW C013567 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mono- and diglycerides
stoichiometric coefficient: 1.0

Reference/UniProt P63001
type: UnificationXref
id: P63001
db: UniProt

SubPathwayInteraction109173
type: Interaction
name: SubPathwayReaction
name: SubPathway109173Reaction
participant: Unknown
participant: Tumor necrosis factor
participant: Mitogen-activated protein kinase 1
participant: Striated muscle-specific serine/threonine-protein kinase
participant: Mitogen-activated protein kinase 14
participant: Mitogen-activated protein kinase 10
participant: Granulocyte-macrophage colony-stimulating factor
participant: Interleukin-5
participant: Protein kinase C alpha type
participant: Interleukin-4
participant: Interleukin-13

ChemicalStructure/PW C000693
type: ChemicalStructure
structure format: SMILES
structure data: NCCC1=CNC=N1

SubPathwayInteraction109175
type: Interaction
name: SubPathwayReaction
name: SubPathway109175Reaction
participant: Histamine
participant: Calcium
participant: Protein kinase C alpha type
participant: Heparin

SubPathwayInteraction109174
type: Interaction
name: SubPathway109174Reaction
name: SubPathwayReaction
participant: Prostaglandin D2
participant: Arachidonic acid
participant: Leukotriene D4
participant: Leukotriene C4
participant: Leukotriene E4

Leukotriene E4
type: SmallMoleculeReference
xref: Reference/CAS 75715-89-8
xref: Reference/ChemSpider 4444402
xref: Reference/PubChem-compound 5280749
xref: Reference/HMDB HMDB0002200
xref: Reference/KEGG Compound C05952
xref: Reference/ChEBI CHEBI 15650
chemical formula: C23H37NO5S
molecular weight: 439.23926
structure: ChemicalStructure/PW C001485

High affinity immunoglobulin epsilon receptor subunit beta
type: Protein
cellular location: Cytosol
entity reference: High affinity immunoglobulin epsilon receptor subunit beta

Linker for activation of T-cells family member 1
type: ProteinReference
xref: Reference/UniProt O54957
organism: Mus musculus

SubPathwayInteraction109177
type: Interaction
name: SubPathway109177Reaction
name: SubPathwayReaction
participant: Dual specificity mitogen-activated protein kinase kinase

Dual specificity mitogen-activated protein kinase kinase 7
type: Protein
cellular location: Cytosol
entity reference: Dual specificity mitogen-activated protein kinase kinase 7

SubPathwayInteraction109176
type: Interaction
name: SubPathway109176Reaction
name: SubPathwayReaction
participant: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

Reference/UniProt Q6P1G1
type: UnificationXref
id: Q6P1G1
db: UniProt

SubPathwayInteraction109178
type: Interaction
name: SubPathway109178Reaction
name: SubPathwayReaction
participant: Arachidonic acid

Reference/CAS 9005-49-6
type: UnificationXref
id: 9005-49-6
db: CAS

Reference/UniProt Q922M0
type: UnificationXref
id: Q922M0
db: UniProt

Reference/UniProt Q61365
type: UnificationXref
id: Q61365
db: UniProt

Reference/UniProt P08643
type: UnificationXref
id: P08643
db: UniProt

Interleukin-5
type: ProteinReference
xref: Reference/UniProt P04401
organism: Mus musculus

Reference/BioCyc LEUKOTRIENE-C4
type: UnificationXref
id: LEUKOTRIENE-C4
db: BioCyc

ProteinComplex/11100 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dual specificity mitogen-activated protein kinase kinase 6
stoichiometric coefficient: 1.0

Interleukin-4
type: ProteinReference
xref: Reference/UniProt P07750
organism: Mus musculus

Calcium
type: SmallMolecule
cellular location: Cytosol
entity reference: Calcium
name: SubPathwayInput

Protein/19624 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mitogen-activated protein kinase 14
stoichiometric coefficient: 1.0

SubPathwayControl109172
type: Interaction
name: SubPathway109172Control
name: InhibitorySubPathwayControl
participant: Phosphatidylinositol-3,4,5-trisphosphate
participant: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 inhibition of Phosphatidylinositol-3,4,5-trisphosphate
participant: SH2 domain-containing protein 1B

Interleukin-4
type: Protein
cellular location: Cytosol
entity reference: Interleukin-4
name: SubPathwayOutput

SubPathwayControl109171
type: Interaction
name: SubPathway109171Control
name: ActivatingSubPathwayControl
participant: Immunoglobulin E
participant: Immunoglobulin Activation
participant: High affinity immunoglobulin epsilon receptor

Protein/19612 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial
stoichiometric coefficient: 2.0

Reference/UniProt Q91VF3
type: UnificationXref
id: Q91VF3
db: UniProt

Leukotriene D4
type: SmallMolecule
cellular location: Cytosol
entity reference: Leukotriene D4
name: SubPathwayOutput

Dual specificity mitogen-activated protein kinase kinase 1
type: Protein
cellular location: Cytosol
entity reference: Dual specificity mitogen-activated protein kinase kinase 1

Reference/HMDB HMDB0001198
type: UnificationXref
id: HMDB0001198
db: HMDB

Reaction174110
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/11133 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19617 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19594 Cytosol/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/11130 Cytosol/Stoichiometry/1.0
right: Ras-related C3 botulinum toxin substrate 1
right: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
right: [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial
spontaneous: true
left: Phosphatidylinositol 3-kinase
name: Phosphatidylinositol 3-kinase → 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 + Ras-related C3 botulinum toxin substrate 1 + [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 4444133
type: UnificationXref
id: 4444133
db: ChemSpider

Reaction174111
type: BiochemicalReaction
participant stoichiometry: Protein/19594 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19599 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19596 Cytosol/Stoichiometry/1.0
right: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
right: Guanine nucleotide exchange factor VAV3
spontaneous: true
left: Lymphocyte cytosolic protein 2
name: Lymphocyte cytosolic protein 2 → 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 + Guanine nucleotide exchange factor VAV3
conversion direction: LEFT_TO_RIGHT

Reference/PathWhiz PW000044
type: UnificationXref
id: PW000044
db: PathWhiz

Reaction174112
type: BiochemicalReaction
participant stoichiometry: Protein/19617 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19599 Cytosol/Stoichiometry/1.0
right: Ras-related C3 botulinum toxin substrate 1
spontaneous: true
left: Guanine nucleotide exchange factor VAV3
name: Guanine nucleotide exchange factor VAV3 → Ras-related C3 botulinum toxin substrate 1
conversion direction: LEFT_TO_RIGHT

Reference/TAXONOMY 10090
type: UnificationXref
id: 10090
db: TAXONOMY

Reaction174113
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/11133 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/11454 Cytosol/Stoichiometry/1.0
right: Striated muscle-specific serine/threonine-protein kinase
spontaneous: true
left: [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial
name: [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial → RAC-alpha serine/threonine-protein kinase
conversion direction: LEFT_TO_RIGHT

Protein/19599 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide exchange factor VAV3
stoichiometric coefficient: 1.0

Reaction174114
type: BiochemicalReaction
participant stoichiometry: Protein/19617 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19621 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19451 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19623 Cytosol/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/11100 Cytosol/Stoichiometry/1.0
right: Dual specificity mitogen-activated protein kinase kinase 4
right: Dual specificity mitogen-activated protein kinase kinase 3
right: Dual specificity mitogen-activated protein kinase kinase 6
right: Dual specificity mitogen-activated protein kinase kinase 7
spontaneous: true
left: Ras-related C3 botulinum toxin substrate 1
name: Ras-related C3 botulinum toxin substrate 1 → Dual specificity mitogen-activated protein kinase kinase 3 + Dual specificity mitogen-activated protein kinase kinase 4 + Dual specificity mitogen-activated protein kinase kinase 6 + Dual specificity mitogen-activated protein kinase kinase 7
conversion direction: LEFT_TO_RIGHT

Reaction174115
type: BiochemicalReaction
participant stoichiometry: Protein/19621 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19451 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19455 Cytosol/Stoichiometry/1.0
right: Mitogen-activated protein kinase 10
spontaneous: true
left: Dual specificity mitogen-activated protein kinase kinase 4
left: Dual specificity mitogen-activated protein kinase kinase 7
name: Dual specificity mitogen-activated protein kinase kinase 4 + Dual specificity mitogen-activated protein kinase kinase 7 → Mitogen-activated protein kinase 8
conversion direction: LEFT_TO_RIGHT

Phosphatidylinositol 3-kinase
type: Complex
component stoichiometry: Protein/16937 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/17374 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Phosphatidylinositol 3-kinase regulatory subunit alpha
component: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Reaction174116
type: BiochemicalReaction
participant stoichiometry: Protein/19623 Cytosol/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/11100 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19624 Cytosol/Stoichiometry/1.0
right: Mitogen-activated protein kinase 14
spontaneous: true
left: Dual specificity mitogen-activated protein kinase kinase 3
left: Dual specificity mitogen-activated protein kinase kinase 6
name: Dual specificity mitogen-activated protein kinase kinase 3 + Dual specificity mitogen-activated protein kinase kinase 6 → Mitogen-activated protein kinase 14
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00219
type: UnificationXref
id: C00219
db: KEGG Compound

High affinity immunoglobulin epsilon receptor subunit gamma
type: Protein
cellular location: Cell Membrane
entity reference: High affinity immunoglobulin epsilon receptor subunit gamma

Reference/KEGG Compound C00696
type: UnificationXref
id: C00696
db: KEGG Compound

Reference/ChEBI CHEBI 16595
type: UnificationXref
id: CHEBI:16595
db: ChEBI

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/UniProt Q8K2A3
type: UnificationXref
id: Q8K2A3
db: UniProt

Reference/HMDB HMDB0001403
type: UnificationXref
id: HMDB0001403
db: HMDB

Reference/UniProt Q3V1U6
type: UnificationXref
id: Q3V1U6
db: UniProt

Immunoglobulin E
type: Complex
component stoichiometry: Protein/19563 Extracellular Space/Stoichiometry/4.0
cellular location: Extracellular Space
component: Ig epsilon chain C region
name: SubPathwayActivation
name: SubPathwayActivator

Reaction174117
type: BiochemicalReaction
participant stoichiometry: Protein/13957 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/11455 Cytosol/Stoichiometry/1.0
right: Endophilin-A3
spontaneous: true
left: Linker for activation of T-cells family member 1
name: Linker for activation of T-cells family member 1 → Growth factor receptor-bound protein 2
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P01587
type: UnificationXref
id: P01587
db: UniProt

Reference/CAS 85166-31-0
type: UnificationXref
id: 85166-31-0
db: CAS

Reaction174119
type: BiochemicalReaction
participant stoichiometry: Protein/11456 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/11455 Cytosol/Stoichiometry/1.0
right: Ras-GEF domain-containing family member 1B
spontaneous: true
left: Endophilin-A3
name: Growth factor receptor-bound protein 2 → Son of sevenless homolog 1
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 17216115
type: UnificationXref
id: 17216115
db: ChemSpider

Reference/PathWhiz PW109180
type: UnificationXref
id: PW109180
db: PathWhiz

ChemicalStructure/PW C001084
type: ChemicalStructure
structure format: SMILES

Protein/19427 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: GTPase HRas
stoichiometric coefficient: 1.0

Protein kinase C alpha type
type: ProteinReference
xref: Reference/UniProt P20444
organism: Mus musculus

Leukotriene C4
type: SmallMoleculeReference
xref: Reference/ChemSpider 4444133
xref: Reference/CAS 72025-60-6
xref: Reference/ChEBI CHEBI 16978
xref: Reference/BioCyc LEUKOTRIENE-C4
xref: Reference/PubChem-compound 5280493
xref: Reference/KEGG Compound C02166
xref: Reference/HMDB HMDB0001198
chemical formula: C30H47N3O9S
molecular weight: 625.3033
structure: ChemicalStructure/PW C000933

Protein/11457 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Receptor-interacting serine/threonine-protein kinase 4
stoichiometric coefficient: 1.0

Reaction174103
type: BiochemicalReaction
participant stoichiometry: Protein/19583 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19574 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19578 Cytosol/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/11117 Cytosol/Stoichiometry/1.0
right: Tyrosine-protein kinase Fyn
right: Tyrosine-protein kinase BTK
spontaneous: true
left: Tyrosine-protein kinase Lyn
left: High affinity immunoglobulin epsilon receptor
name: High affinity immunoglobulin epsilon receptor + Tyrosine-protein kinase Lyn → Tyrosine-protein kinase BTK + Tyrosine-protein kinase Fyn
conversion direction: LEFT_TO_RIGHT

Reaction174104
type: BiochemicalReaction
participant stoichiometry: Protein/19589 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19584 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19594 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19599 Cytosol/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/11117 Cytosol/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/11130 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19596 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/13957 Cytosol/Stoichiometry/1.0
right: Lymphocyte cytosolic protein 2
right: Linker for activation of T-cells family member 1
right: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
right: Phosphatidylinositol 3-kinase
right: Guanine nucleotide exchange factor VAV3
right: GRB2-associated-binding protein 2
spontaneous: true
left: High affinity immunoglobulin epsilon receptor
left: Tyrosine-protein kinase SYK
name: High affinity immunoglobulin epsilon receptor + Tyrosine-protein kinase SYK → 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 + GRB2-associated-binding protein 2 + Guanine nucleotide exchange factor VAV3 + Linker for activation of T-cells family member 1 + Lymphocyte cytosolic protein 2 + Phosphatidylinositol 3-kinase
conversion direction: LEFT_TO_RIGHT

Reference/UniProt O54957
type: UnificationXref
id: O54957
db: UniProt

Reaction174105
type: BiochemicalReaction
participant stoichiometry: Protein/19578 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19594 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002108 Cytosol/Stoichiometry/1.0
right: Phosphatidylinositol-3,4,5-trisphosphate
right: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
spontaneous: true
left: Phosphatidylinositol-3,4,5-trisphosphate
left: Tyrosine-protein kinase BTK
name: Phosphatidylinositol-3,4,5-trisphosphate + Tyrosine-protein kinase BTK → 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 + Phosphatidylinositol-3,4,5-trisphosphate
conversion direction: LEFT_TO_RIGHT

Dual specificity mitogen-activated protein kinase kinase 2
type: Protein
cellular location: Cytosol
entity reference: Dual specificity mitogen-activated protein kinase kinase 2

Reference/PubChem-compound 5280493
type: UnificationXref
id: 5280493
db: PubChem-compound

Reference/BioCyc HEPARIN
type: UnificationXref
id: HEPARIN
db: BioCyc

Reference/HMDB HMDB0004249
type: UnificationXref
id: HMDB0004249
db: HMDB

ProteinComplex/11133 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial
stoichiometric coefficient: 1.0

Protein/11456 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ras-GEF domain-containing family member 1B
stoichiometric coefficient: 1.0

Reference/UniProt Q9D7B0
type: UnificationXref
id: Q9D7B0
db: UniProt

Reference/UniProt Q8K3B3
type: UnificationXref
id: Q8K3B3
db: UniProt

ChemicalStructure/PW C001775
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Mono- and diglycerides
type: SmallMoleculeReference
xref: Reference/CAS 67254-73-3
xref: Reference/PubChem-compound 6850771
xref: Reference/ChemSpider 5254058
xref: Reference/HMDB HMDB0032436
chemical formula: C100H188O22
molecular weight: 1741.3593
structure: ChemicalStructure/PW C013567

Ras-GEF domain-containing family member 1B
type: Protein
cellular location: Cytosol
entity reference: Ras-GEF domain-containing family member 1B

Reaction174106
type: BiochemicalReaction
participant stoichiometry: Protein/19583 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19589 Cytosol/Stoichiometry/1.0
right: GRB2-associated-binding protein 2
spontaneous: true
left: Tyrosine-protein kinase Fyn
name: Tyrosine-protein kinase Fyn → GRB2-associated-binding protein 2
conversion direction: LEFT_TO_RIGHT

Interleukin-5
type: Complex
component stoichiometry: Protein/14011 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Interleukin-5
name: SubPathwayOutput

Reaction174107
type: BiochemicalReaction
participant stoichiometry: Protein/19589 Cytosol/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/11130 Cytosol/Stoichiometry/1.0
right: Phosphatidylinositol 3-kinase
spontaneous: true
left: GRB2-associated-binding protein 2
name: GRB2-associated-binding protein 2 → Phosphatidylinositol 3-kinase
conversion direction: LEFT_TO_RIGHT

Reaction174108
type: BiochemicalReaction
participant stoichiometry: Protein/19594 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C013567 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001155 Cytosol/Stoichiometry/1.0
right: Mono- and diglycerides
right: Inositol 1,4,5-trisphosphate
spontaneous: true
left: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 → Inositol 1,4,5-trisphosphate + Mono- and diglycerides
conversion direction: LEFT_TO_RIGHT

Mus musculus
type: BioSource
xref: Reference/TAXONOMY 10090

Reaction174109
type: BiochemicalReaction
participant stoichiometry: Protein/19607 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C013567 Cytosol/Stoichiometry/1.0
right: Protein kinase C alpha type
spontaneous: true
left: Mono- and diglycerides
name: Mono- and diglycerides → Protein kinase C alpha type
conversion direction: LEFT_TO_RIGHT

Protein kinase C alpha type
type: Protein
cellular location: Cytosol
entity reference: Protein kinase C alpha type
name: SubPathwayInput

Protein/19563 Extracellular Space/Stoichiometry/4.0
type: Stoichiometry
physical entity: Ig epsilon chain C region
stoichiometric coefficient: 4.0

Mitogen-activated protein kinase 14
type: Protein
cellular location: Cytosol
entity reference: Mitogen-activated protein kinase 14
name: SubPathwayInput

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: Protein
cellular location: Cytosol
entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
name: SubPathwayInput

ChemicalStructure/PW C013567
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 16978
type: UnificationXref
id: CHEBI:16978
db: ChEBI

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Compound/PW C001155 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate
stoichiometric coefficient: 1.0

Reference/UniProt E9QLR4
type: UnificationXref
id: E9QLR4
db: UniProt

Reference/UniProt Q62407
type: UnificationXref
id: Q62407
db: UniProt

Phosphatidylinositol signaling system
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway109176
pathway component: SubPathwayInteraction109176
name: SubPathway

MAPK signaling pathway
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway109177
pathway component: SubPathwayInteraction109177
name: SubPathway

Dual specificity mitogen-activated protein kinase kinase 7
type: ProteinReference
xref: Reference/UniProt Q9R1Z6
organism: Mus musculus

Generation of eicosanoids
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway109174
pathway component: SubPathwayInteraction109174
name: SubPathway

Protein/19574 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tyrosine-protein kinase Lyn
stoichiometric coefficient: 1.0

Ig epsilon chain C region
type: Protein
cellular location: Extracellular Space
entity reference: Ig epsilon chain C region

Degranulation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway109175
pathway component: SubPathwayInteraction109175
name: SubPathway

Tyrosine-protein kinase Lyn
type: ProteinReference
xref: Reference/UniProt Q62127
organism: Mus musculus

Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 inhibition of Phosphatidylinositol-3,4,5-trisphosphate
type: Pathway
name: InhibitorySubPathway

Cytokine gene transcription
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway109173
pathway component: SubPathwayInteraction109173
name: SubPathway

Mitogen-activated protein kinase 10
type: ProteinReference
xref: Reference/UniProt Q9R0U6
organism: Mus musculus

Immunoglobulin Activation
type: Pathway
name: ActivatingSubPathway

Tyrosine-protein kinase BTK
type: ProteinReference
xref: Reference/UniProt Q61365
organism: Mus musculus

Reference/UniProt Q3U5E5
type: UnificationXref
id: Q3U5E5
db: UniProt

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Protein/19565 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: High affinity immunoglobulin epsilon receptor subunit alpha
stoichiometric coefficient: 1.0

SH2 domain-containing protein 1B
type: Protein
cellular location: Cytosol
entity reference: SH2 domain-containing protein 1B
name: SubPathwayInhibitor

Reference/BioCyc inositol 1,4,5-trisphosphate
type: UnificationXref
id: inositol_1,4,5-trisphosphate
db: BioCyc

Reference/UniProt Q9R1Z6
type: UnificationXref
id: Q9R1Z6
db: UniProt

Reaction174120
type: BiochemicalReaction
participant stoichiometry: Protein/11456 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19637 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19635 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19427 Cytosol/Stoichiometry/1.0
right: GTPase HRas
right: GTPase KRas
right: GTPase NRas
spontaneous: true
left: Ras-GEF domain-containing family member 1B
name: Son of sevenless homolog 1 → GTPase HRas + GTPase KRas + GTPase NRas
conversion direction: LEFT_TO_RIGHT

Reaction174121
type: BiochemicalReaction
participant stoichiometry: Protein/11457 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19637 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19635 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19427 Cytosol/Stoichiometry/1.0
right: Receptor-interacting serine/threonine-protein kinase 4
spontaneous: true
left: GTPase HRas
left: GTPase KRas
left: GTPase NRas
name: GTPase HRas + GTPase KRas + GTPase NRas → RAF proto-oncogene serine/threonine-protein kinase
conversion direction: LEFT_TO_RIGHT

Reaction174122
type: BiochemicalReaction
participant stoichiometry: Protein/11457 Cytosol/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/11124 Cytosol/Stoichiometry/1.0
right: Dual specificity mitogen-activated protein kinase kinase
spontaneous: true
left: Receptor-interacting serine/threonine-protein kinase 4
name: RAF proto-oncogene serine/threonine-protein kinase → Dual specificity mitogen-activated protein kinase kinase
conversion direction: LEFT_TO_RIGHT

Reaction174123
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/11124 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19415 Cytosol/Stoichiometry/1.0
right: Mitogen-activated protein kinase 1
spontaneous: true
left: Dual specificity mitogen-activated protein kinase kinase
name: Dual specificity mitogen-activated protein kinase kinase → Mitogen-activated protein kinase 1
conversion direction: LEFT_TO_RIGHT

Reaction174124
type: BiochemicalReaction
participant stoichiometry: Protein/7736 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19415 Cytosol/Stoichiometry/1.0
right: Unknown
spontaneous: true
left: Mitogen-activated protein kinase 1
name: Mitogen-activated protein kinase 1 → Cytosolic phospholipase A2
conversion direction: LEFT_TO_RIGHT

Reaction174125
type: BiochemicalReaction
participant stoichiometry: Protein/7736 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000821 Cytosol/Stoichiometry/1.0
right: Arachidonic acid
spontaneous: true
left: Unknown
name: Cytosolic phospholipase A2 → Arachidonic acid
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P07750
type: UnificationXref
id: P07750
db: UniProt

Protein/7736 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 1.0

Reference/UniProt Q8JZL7
type: UnificationXref
id: Q8JZL7
db: UniProt

Protein/19455 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mitogen-activated protein kinase 10
stoichiometric coefficient: 1.0

High affinity immunoglobulin epsilon receptor subunit alpha
type: Protein
cellular location: Cell Membrane
entity reference: High affinity immunoglobulin epsilon receptor subunit alpha

Protein/19565 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: High affinity immunoglobulin epsilon receptor subunit alpha
stoichiometric coefficient: 1.0

Leukotriene E4
type: SmallMolecule
cellular location: Cytosol
entity reference: Leukotriene E4
name: SubPathwayOutput

Tyrosine-protein kinase SYK
type: Protein
cellular location: Cytosol
entity reference: Tyrosine-protein kinase SYK

Reference/ChEBI CHEBI 15650
type: UnificationXref
id: CHEBI:15650
db: ChEBI

Reference/ChemSpider 388562
type: UnificationXref
id: 388562
db: ChemSpider

ChemicalStructure/PW C000933
type: ChemicalStructure
structure format: SMILES

Reference/CAS 75715-89-8
type: UnificationXref
id: 75715-89-8
db: CAS

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

Tyrosine-protein kinase Fyn
type: ProteinReference
xref: Reference/UniProt Q8K2A3
organism: Mus musculus

Protein/19594 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
stoichiometric coefficient: 1.0

Tyrosine-protein kinase SYK
type: ProteinReference
xref: Reference/UniProt P48025
organism: Mus musculus

Granulocyte-macrophage colony-stimulating factor
type: Protein
cellular location: Cytosol
entity reference: Granulocyte-macrophage colony-stimulating factor
name: SubPathwayOutput

GRB2-associated-binding protein 2
type: ProteinReference
xref: Reference/UniProt Q9R1X3
organism: Mus musculus

Dual specificity mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: Reference/UniProt P70236
organism: Mus musculus

Protein/16937 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16618
type: UnificationXref
id: CHEBI:16618
db: ChEBI

Leukotriene C4
type: SmallMolecule
cellular location: Cytosol
entity reference: Leukotriene C4
name: SubPathwayOutput

Reference/PubChem-compound 22833565
type: UnificationXref
id: 22833565
db: PubChem-compound

Arachidonic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Arachidonic acid
name: SubPathwayInput

Linker for activation of T-cells family member 1
type: Protein
cellular location: Cytosol
entity reference: Linker for activation of T-cells family member 1

Reference/UniProt Q62421
type: UnificationXref
id: Q62421
db: UniProt

Reference/KEGG Compound C00374
type: UnificationXref
id: C00374
db: KEGG Compound

Reference/PubChem-compound 448457
type: UnificationXref
id: 448457
db: PubChem-compound

Phosphatidylinositol-3,4,5-trisphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0004249
xref: Reference/KEGG Compound C05981
xref: Reference/ChEBI CHEBI 16618
xref: Reference/BioCyc PHOSPHATIDYL-INOSITOL-345-TRISPHOSPHAT
chemical formula: C12H24O22P4
molecular weight: 643.97095
structure: ChemicalStructure/PW C002108

Reference/BioCyc PHOSPHATIDYL-INOSITOL-345-TRISPHOSPHAT
type: UnificationXref
id: PHOSPHATIDYL-INOSITOL-345-TRISPHOSPHAT
db: BioCyc

Reference/PubChem-compound 444899
type: UnificationXref
id: 444899
db: PubChem-compound

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Mitogen-activated protein kinase 1
type: Protein
cellular location: Cytosol
entity reference: Mitogen-activated protein kinase 1
name: SubPathwayInput

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: Reference/UniProt Q6P1G1
organism: Mus musculus

Protein/14099 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: High affinity immunoglobulin epsilon receptor subunit gamma
stoichiometric coefficient: 2.0

Lymphocyte cytosolic protein 2
type: ProteinReference
xref: Reference/UniProt Q922M0
organism: Mus musculus

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

Guanine nucleotide exchange factor VAV3
type: ProteinReference
xref: Reference/UniProt Q9JLS6
organism: Mus musculus

Reference/UniProt Q9R1X3
type: UnificationXref
id: Q9R1X3
db: UniProt

Protein/19467 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Dual specificity mitogen-activated protein kinase kinase 6
stoichiometric coefficient: 2.0

Unknown
type: Protein
cellular location: Cytosol
entity reference: Unknown
name: SubPathwayOutput

Striated muscle-specific serine/threonine-protein kinase
type: Protein
cellular location: Cytosol
entity reference: Striated muscle-specific serine/threonine-protein kinase
name: SubPathwayInput

Protein/19568 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: High affinity immunoglobulin epsilon receptor subunit beta
stoichiometric coefficient: 1.0

Ras-related C3 botulinum toxin substrate 1
type: Protein
cellular location: Cytosol
entity reference: Ras-related C3 botulinum toxin substrate 1

Interleukin-13
type: ProteinReference
xref: Reference/UniProt P20109
organism: Mus musculus

High affinity immunoglobulin epsilon receptor subunit beta
type: Protein
cellular location: Cell Membrane
entity reference: High affinity immunoglobulin epsilon receptor subunit beta

Guanine nucleotide exchange factor VAV3
type: Protein
cellular location: Cytosol
entity reference: Guanine nucleotide exchange factor VAV3

Reference/KEGG Compound C05952
type: UnificationXref
id: C05952
db: KEGG Compound

Reference/KEGG Compound C00388
type: UnificationXref
id: C00388
db: KEGG Compound

Reference/KEGG Compound C05951
type: UnificationXref
id: C05951
db: KEGG Compound

Protein/19583 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tyrosine-protein kinase Fyn
stoichiometric coefficient: 1.0

Reference/UniProt O35324
type: UnificationXref
id: O35324
db: UniProt

Inositol 1,4,5-trisphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001498
xref: Reference/PubChem-compound 439456
xref: Reference/CAS 85166-31-0
xref: Reference/BioCyc inositol 1,4,5-trisphosphate
xref: Reference/KEGG Compound C01245
xref: Reference/ChEBI CHEBI 16595
xref: Reference/ChemSpider 388562
chemical formula: C6H15O15P3
molecular weight: 419.96237
structure: ChemicalStructure/PW C001155

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Heparin
type: SmallMolecule
cellular location: Cytosol
entity reference: Heparin
name: SubPathwayOutput

Tyrosine-protein kinase BTK
type: Protein
cellular location: Cytosol
entity reference: Tyrosine-protein kinase BTK

Interleukin-13
type: Protein
cellular location: Cytosol
entity reference: Interleukin-13
name: SubPathwayOutput

Reference/SMPDB SMP0000075
type: UnificationXref
id: SMP0000075
db: SMPDB

Reference/UniProt Q811B9
type: UnificationXref
id: Q811B9
db: UniProt

Reference/SMPDB SMP0108139
type: UnificationXref
id: SMP0108139
db: SMPDB

Reference/HMDB HMDB0003080
type: UnificationXref
id: HMDB0003080
db: HMDB

Mitogen-activated protein kinase 10
type: Protein
cellular location: Cytosol
entity reference: Mitogen-activated protein kinase 10
name: SubPathwayInput

Reference/CAS 51-45-6
type: UnificationXref
id: 51-45-6
db: CAS

Reference/UniProt P31938
type: UnificationXref
id: P31938
db: UniProt

ChemicalStructure/PW C002108
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C01245
type: UnificationXref
id: C01245
db: KEGG Compound

Protein/11455 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Endophilin-A3
stoichiometric coefficient: 1.0

Protein/19607 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Protein kinase C alpha type
stoichiometric coefficient: 1.0

Phosphatidylinositol-3,4,5-trisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphatidylinositol-3,4,5-trisphosphate
name: SubPathwayInhibition

Reference/UniProt Q9JLS6
type: UnificationXref
id: Q9JLS6
db: UniProt

Reference/BioCyc 5Z13E-15S-9-ALPHA15-DIHYDROXY-11-O
type: UnificationXref
id: 5Z13E-15S-9-ALPHA15-DIHYDROXY-11-O
db: BioCyc

Mitogen-activated protein kinase 1
type: ProteinReference
xref: Reference/UniProt Q3V1U6
organism: Mus musculus

Reference/ChemSpider 392692
type: UnificationXref
id: 392692
db: ChemSpider

Prostaglandin D2
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15555
xref: Reference/ChemSpider 395250
xref: Reference/HMDB HMDB0001403
xref: Reference/BioCyc 5Z13E-15S-9-ALPHA15-DIHYDROXY-11-O
xref: Reference/PubChem-compound 448457
xref: Reference/KEGG Compound C00696
xref: Reference/CAS 41598-07-6
chemical formula: C20H32O5
molecular weight: 352.22498
structure: ChemicalStructure/PW C001084

Protein/19568 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: High affinity immunoglobulin epsilon receptor subunit beta
stoichiometric coefficient: 1.0

High affinity immunoglobulin epsilon receptor subunit gamma
type: ProteinReference
xref: Reference/UniProt P20491
organism: Mus musculus

Protein/14011 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Interleukin-5
stoichiometric coefficient: 2.0

Reference/UniProt P48025
type: UnificationXref
id: P48025
db: UniProt

Protein/17374 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol 3-kinase regulatory subunit alpha
stoichiometric coefficient: 1.0

High affinity immunoglobulin epsilon receptor
type: Complex
component stoichiometry: Protein/14099 Cell Membrane/Stoichiometry/2.0
component stoichiometry: Protein/19568 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/19565 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: High affinity immunoglobulin epsilon receptor subunit beta
component: High affinity immunoglobulin epsilon receptor subunit alpha
component: High affinity immunoglobulin epsilon receptor subunit gamma
name: SubPathwayActivation
name: SubPathwayActivator

GTPase NRas
type: Protein
cellular location: Cytosol
entity reference: GTPase NRas

Tumor necrosis factor
type: Protein
cellular location: Cytosol
entity reference: Tumor necrosis factor

ChemicalStructure/PW C001155
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C05981
type: UnificationXref
id: C05981
db: KEGG Compound

Protein/19578 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tyrosine-protein kinase BTK
stoichiometric coefficient: 1.0

Lymphocyte cytosolic protein 2
type: Protein
cellular location: Cytosol
entity reference: Lymphocyte cytosolic protein 2

Histamine
type: SmallMolecule
cellular location: Cytosol
entity reference: Histamine
name: SubPathwayOutput

Dual specificity mitogen-activated protein kinase kinase 3
type: Protein
cellular location: Cytosol
entity reference: Dual specificity mitogen-activated protein kinase kinase 3

Receptor-interacting serine/threonine-protein kinase 4
type: Protein
cellular location: Cytosol
entity reference: Receptor-interacting serine/threonine-protein kinase 4

GTPase HRas
type: ProteinReference
xref: Reference/UniProt Q811B9
organism: Mus musculus

Reference/HMDB HMDB0002200
type: UnificationXref
id: HMDB0002200
db: HMDB

Reference/UniProt Q9R0U6
type: UnificationXref
id: Q9R0U6
db: UniProt

Reference/UniProt P01856
type: UnificationXref
id: P01856
db: UniProt

Reference/PubChem-compound 5280878
type: UnificationXref
id: 5280878
db: PubChem-compound

Prostaglandin D2
type: SmallMolecule
cellular location: Cytosol
entity reference: Prostaglandin D2
name: SubPathwayOutput

High affinity immunoglobulin epsilon receptor
type: Complex
component stoichiometry: Protein/19568 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/14099 Cytosol/Stoichiometry/2.0
component stoichiometry: Protein/19565 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: High affinity immunoglobulin epsilon receptor subunit beta
component: High affinity immunoglobulin epsilon receptor subunit alpha
component: High affinity immunoglobulin epsilon receptor subunit gamma

Phosphatidylinositol 3-kinase regulatory subunit alpha
type: Protein
cellular location: Cytosol
entity reference: Phosphatidylinositol 3-kinase regulatory subunit alpha

ChemicalStructure/PW C000821
type: ChemicalStructure
structure format: SMILES
structure data: CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O

Dual specificity mitogen-activated protein kinase kinase 4
type: Protein
cellular location: Cytosol
entity reference: Dual specificity mitogen-activated protein kinase kinase 4

[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial
type: Protein
cellular location: Cytosol
entity reference: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial

Reference/UniProt Q9ERK0
type: UnificationXref
id: Q9ERK0
db: UniProt

ChemicalStructure/PW C001485
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 439456
type: UnificationXref
id: 439456
db: PubChem-compound

Dual specificity mitogen-activated protein kinase kinase 6
type: Protein
cellular location: Cytosol
entity reference: Dual specificity mitogen-activated protein kinase kinase 6

Phosphatidylinositol 3-kinase regulatory subunit alpha
type: ProteinReference
xref: Reference/UniProt Q8K3B3
organism: Mus musculus

ProteinComplex/11124 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dual specificity mitogen-activated protein kinase kinase
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15555
type: UnificationXref
id: CHEBI:15555
db: ChEBI

Reference/ChemSpider 4444401
type: UnificationXref
id: 4444401
db: ChemSpider

Reference/ChemSpider 4444402
type: UnificationXref
id: 4444402
db: ChemSpider

Reference/PubChem-compound 774
type: UnificationXref
id: 774
db: PubChem-compound

Reference/UniProt P20491
type: UnificationXref
id: P20491
db: UniProt

Reference/UniProt P20490
type: UnificationXref
id: P20490
db: UniProt

Protein/19596 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lymphocyte cytosolic protein 2
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001498
type: UnificationXref
id: HMDB0001498
db: HMDB

Protein/19589 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: GRB2-associated-binding protein 2
stoichiometric coefficient: 1.0

Protein/19451 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dual specificity mitogen-activated protein kinase kinase 7
stoichiometric coefficient: 1.0

Ig epsilon chain C region
type: ProteinReference
xref: Reference/UniProt P01856
organism: Mus musculus

Heparin
type: SmallMoleculeReference
xref: Reference/CAS 9005-49-6
xref: Reference/ChEBI CHEBI 28304
xref: Reference/KEGG Compound C00374
xref: Reference/ChemSpider 17216115
xref: Reference/HMDB HMDB0001394
xref: Reference/BioCyc HEPARIN
xref: Reference/PubChem-compound 22833565
chemical formula: (C12H19NO19S3)nH2O
structure: ChemicalStructure/PW C001078

High affinity immunoglobulin epsilon receptor subunit alpha
type: ProteinReference
xref: Reference/UniProt E9QLR4
organism: Mus musculus

Compound/PW C002108 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol-3,4,5-trisphosphate
stoichiometric coefficient: 1.0

Compound/PW C000821 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Arachidonic acid
stoichiometric coefficient: 1.0

High affinity immunoglobulin epsilon receptor subunit gamma
type: Protein
cellular location: Cytosol
entity reference: High affinity immunoglobulin epsilon receptor subunit gamma

High affinity immunoglobulin epsilon receptor subunit beta
type: ProteinReference
xref: Reference/UniProt P20490
organism: Mus musculus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: Protein
cellular location: Cytosol
entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Reference/UniProt Q9QZ80
type: UnificationXref
id: Q9QZ80
db: UniProt

Reference/UniProt P08556
type: UnificationXref
id: P08556
db: UniProt

Tumor necrosis factor
type: Complex
component stoichiometry: Protein/19649 Cytosol/Stoichiometry/3.0
cellular location: Cytosol
component: Tumor necrosis factor
name: SubPathwayOutput

Endophilin-A3
type: ProteinReference
xref: Reference/UniProt Q62421
organism: Mus musculus

Striated muscle-specific serine/threonine-protein kinase
type: ProteinReference
xref: Reference/UniProt Q62407
organism: Mus musculus

Reference/UniProt Q62127
type: UnificationXref
id: Q62127
db: UniProt

Unknown
type: ProteinReference
organism: Mus musculus

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Reference/UniProt Q0VGQ5
type: UnificationXref
id: Q0VGQ5
db: UniProt

Reference/UniProt P20444
type: UnificationXref
id: P20444
db: UniProt

Protein/11454 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Striated muscle-specific serine/threonine-protein kinase
stoichiometric coefficient: 1.0

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Arachidonic Acid Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway109178
pathway component: SubPathwayInteraction109178
xref: Reference/PathWhiz PW000044
xref: Reference/SMPDB SMP0000075
name: SubPathway

Protein/19621 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dual specificity mitogen-activated protein kinase kinase 4
stoichiometric coefficient: 1.0

Reference/UniProt P47809
type: UnificationXref
id: P47809
db: UniProt

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q3U5E5
organism: Mus musculus

Receptor-interacting serine/threonine-protein kinase 4
type: ProteinReference
xref: Reference/UniProt Q9ERK0
organism: Mus musculus

Granulocyte-macrophage colony-stimulating factor
type: ProteinReference
xref: Reference/UniProt P01587
organism: Mus musculus

ProteinComplex/11117 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: High affinity immunoglobulin epsilon receptor
stoichiometric coefficient: 1.0

Ras-GEF domain-containing family member 1B
type: ProteinReference
xref: Reference/UniProt Q8JZL7
organism: Mus musculus

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: Reference/UniProt P63001
organism: Mus musculus

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Protein/19617 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ras-related C3 botulinum toxin substrate 1
stoichiometric coefficient: 1.0

Protein/19404 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dual specificity mitogen-activated protein kinase kinase 2
stoichiometric coefficient: 1.0

Reference/UniProt P04401
type: UnificationXref
id: P04401
db: UniProt

Endophilin-A3
type: Protein
cellular location: Cytosol
entity reference: Endophilin-A3

Reference/BioCyc HISTAMINE
type: UnificationXref
id: HISTAMINE
db: BioCyc

Reference/HMDB HMDB0032436
type: UnificationXref
id: HMDB0032436
db: HMDB

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

GRB2-associated-binding protein 2
type: Protein
cellular location: Cytosol
entity reference: GRB2-associated-binding protein 2

Mono- and diglycerides
type: SmallMolecule
cellular location: Cytosol
entity reference: Mono- and diglycerides

ChemicalStructure/PW C001078
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 395250
type: UnificationXref
id: 395250
db: ChemSpider

Protein/19623 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dual specificity mitogen-activated protein kinase kinase 3
stoichiometric coefficient: 1.0

High affinity immunoglobulin epsilon receptor subunit alpha
type: Protein
cellular location: Cytosol
entity reference: High affinity immunoglobulin epsilon receptor subunit alpha

Dual specificity mitogen-activated protein kinase kinase 4
type: ProteinReference
xref: Reference/UniProt P47809
organism: Mus musculus

Mitogen-activated protein kinase 14
type: ProteinReference
xref: Reference/UniProt Q9QZ80
organism: Mus musculus

Dual specificity mitogen-activated protein kinase kinase 3
type: ProteinReference
xref: Reference/UniProt Q91VX1
organism: Mus musculus

GTPase KRas
type: Protein
cellular location: Cytosol
entity reference: GTPase KRas

Reference/HMDB HMDB0001394
type: UnificationXref
id: HMDB0001394
db: HMDB

ProteinComplex/11130 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol 3-kinase
stoichiometric coefficient: 1.0

Protein/13957 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Linker for activation of T-cells family member 1
stoichiometric coefficient: 1.0

Reference/CAS 72025-60-6
type: UnificationXref
id: 72025-60-6
db: CAS

Reference/ChemSpider 5254058
type: UnificationXref
id: 5254058
db: ChemSpider

Leukotriene D4
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 28666
xref: Reference/ChemSpider 4444401
xref: Reference/HMDB HMDB0003080
xref: Reference/CAS 73836-78-9
xref: Reference/KEGG Compound C05951
xref: Reference/PubChem-compound 5280878
chemical formula: C25H40N2O6S
molecular weight: 496.2607
structure: ChemicalStructure/PW C001775

Protein/19637 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: GTPase KRas
stoichiometric coefficient: 1.0

Fc Epsilon Receptor I Signaling in Mast Cells
type: Pathway
pathway order: PathwayEnzymeReaction/2117634
pathway order: PathwayEnzymeReaction/2117635
pathway order: PathwayEnzymeReaction/2117636
pathway order: PathwayEnzymeReaction/2117637
pathway order: PathwayEnzymeReaction/2117630
pathway order: PathwayEnzymeReaction/2117631
pathway order: PathwayEnzymeReaction/2117632
pathway order: PathwayEnzymeReaction/2117633
pathway order: PathwayEnzymeReaction/2117616
pathway order: PathwayEnzymeReaction/2117617
pathway order: PathwayEnzymeReaction/2117618
pathway order: PathwayEnzymeReaction/2117619
pathway order: PathwayEnzymeReaction/2117623
pathway order: PathwaySubPathway/109178
pathway order: PathwayEnzymeReaction/2117624
pathway order: PathwaySubPathway/109177
pathway order: PathwayEnzymeReaction/2117625
pathway order: PathwayEnzymeReaction/2117626
pathway order: PathwaySubPathway/109174
pathway order: PathwayEnzymeReaction/2117620
pathway order: PathwaySubPathway/109173
pathway order: PathwayEnzymeReaction/2117621
pathway order: PathwaySubPathway/109176
pathway order: PathwayEnzymeReaction/2117622
pathway order: PathwaySubPathway/109175
pathway order: PathwayEnzymeReaction/2117627
pathway order: PathwayEnzymeReaction/2117628
pathway order: PathwayEnzymeReaction/2117629
pathway order: PathwaySubPathway/109172
pathway order: PathwaySubPathway/109171
pathway component: Reaction174110
pathway component: Reaction174111
pathway component: Reaction174112
pathway component: Reaction174113
pathway component: Reaction174114
pathway component: Reaction174115
pathway component: Reaction174116
pathway component: Phosphatidylinositol signaling system
pathway component: MAPK signaling pathway
pathway component: Generation of eicosanoids
pathway component: Degranulation
pathway component: Arachidonic Acid Metabolism
pathway component: Cytokine gene transcription
pathway component: Reaction174117
pathway component: Reaction174119
pathway component: Reaction174120
pathway component: Reaction174121
pathway component: Reaction174122
pathway component: Reaction174123
pathway component: Reaction174124
pathway component: Reaction174103
pathway component: Reaction174125
pathway component: Reaction174104
pathway component: Reaction174105
pathway component: SubPathwayControl109172
pathway component: SubPathwayControl109171
pathway component: Reaction174106
pathway component: Reaction174107
pathway component: Reaction174108
pathway component: Reaction174109
xref: Reference/SMPDB SMP0108139
xref: Reference/PathWhiz PW109180
organism: Mus musculus

Reference/ChEBI CHEBI 18295
type: UnificationXref
id: CHEBI:18295
db: ChEBI

Reference/CAS 41598-07-6
type: UnificationXref
id: 41598-07-6
db: CAS

Tyrosine-protein kinase Lyn
type: Protein
cellular location: Cytosol
entity reference: Tyrosine-protein kinase Lyn

Reference/HMDB HMDB0000870
type: UnificationXref
id: HMDB0000870
db: HMDB

Reference/ChemSpider 753
type: UnificationXref
id: 753
db: ChemSpider

Reference/ChEBI CHEBI 28666
type: UnificationXref
id: CHEBI:28666
db: ChEBI

Reference/ChEBI CHEBI 28304
type: UnificationXref
id: CHEBI:28304
db: ChEBI

Reference/PubChem-compound 6850771
type: UnificationXref
id: 6850771
db: PubChem-compound

Protein/19640 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dual specificity mitogen-activated protein kinase kinase 1
stoichiometric coefficient: 1.0

GTPase NRas
type: ProteinReference
xref: Reference/UniProt P08556
organism: Mus musculus

Reference/PubChem-compound 5280749
type: UnificationXref
id: 5280749
db: PubChem-compound

Histamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000870
xref: Reference/ChemSpider 753
xref: Reference/PubChem-compound 774
xref: Reference/BioCyc HISTAMINE
xref: Reference/CAS 51-45-6
xref: Reference/ChEBI CHEBI 18295
xref: Reference/KEGG Compound C00388
chemical formula: C5H9N3
molecular weight: 111.07965
structure: ChemicalStructure/PW C000693

Dual specificity mitogen-activated protein kinase kinase 6
type: Complex
component stoichiometry: Protein/19467 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Dual specificity mitogen-activated protein kinase kinase 6

GTPase KRas
type: ProteinReference
xref: Reference/UniProt P08643
organism: Mus musculus

Reference/HMDB HMDB0001043
type: UnificationXref
id: HMDB0001043
db: HMDB

Reference/UniProt P20109
type: UnificationXref
id: P20109
db: UniProt

Reference/CAS 506-32-1
type: UnificationXref
id: 506-32-1
db: CAS

Dual specificity mitogen-activated protein kinase kinase
type: Complex
component stoichiometry: Protein/19404 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/19640 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Dual specificity mitogen-activated protein kinase kinase 2
component: Dual specificity mitogen-activated protein kinase kinase 1
name: SubPathwayInput

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: Reference/UniProt Q0VGQ5
organism: Mus musculus

Protein/14099 Cell Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: High affinity immunoglobulin epsilon receptor subunit gamma
stoichiometric coefficient: 2.0

Interleukin-5
type: Protein
cellular location: Cytosol
entity reference: Interleukin-5

Tyrosine-protein kinase Fyn
type: Protein
cellular location: Cytosol
entity reference: Tyrosine-protein kinase Fyn

Protein/19415 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mitogen-activated protein kinase 1
stoichiometric coefficient: 1.0

Reference/KEGG Compound C02166
type: UnificationXref
id: C02166
db: KEGG Compound

Protein/19635 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: GTPase NRas
stoichiometric coefficient: 1.0

Reference/UniProt P70236
type: UnificationXref
id: P70236
db: UniProt

Reference/BioCyc ARACHIDONIC ACID
type: UnificationXref
id: ARACHIDONIC_ACID
db: BioCyc

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: Reference/UniProt P31938
organism: Mus musculus

Reference/CAS 67254-73-3
type: UnificationXref
id: 67254-73-3
db: CAS

Protein/19649 Cytosol/Stoichiometry/3.0
type: Stoichiometry
physical entity: Tumor necrosis factor
stoichiometric coefficient: 3.0

Inositol 1,4,5-trisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Inositol 1,4,5-trisphosphate

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: Reference/UniProt Q9D7B0
organism: Mus musculus

Reference/CAS 73836-78-9
type: UnificationXref
id: 73836-78-9
db: CAS

SH2 domain-containing protein 1B
type: ProteinReference
xref: Reference/UniProt O35324
organism: Mus musculus

Tumor necrosis factor
type: ProteinReference
xref: Reference/UniProt Q91VF3
organism: Mus musculus