ReactionCatalysis37444
type: Catalysis
controller: TBC domain-containing protein kinase-like protein
controlled: 2.7.10.1
control type: ACTIVATION

ProteinComplex/5241 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol 4,5-bisphosphate 3-kinase
stoichiometric coefficient: 1.0

Protein/11458 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ribosomal protein S6 kinase alpha-2
stoichiometric coefficient: 1.0

Protein/19660 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Insulin receptor substrate 2
stoichiometric coefficient: 1.0

ReactionCatalysis37446
type: Catalysis
controller: TBC domain-containing protein kinase-like protein
controlled: 2.7.10.1
control type: ACTIVATION

ReactionCatalysis37445
type: Catalysis
controller: TBC domain-containing protein kinase-like protein
controlled: 2.7.10.1
control type: ACTIVATION

RAF proto-oncogene serine/threonine-protein kinase recruited by GTPase HRas
type: Complex
component stoichiometry: Protein/11450 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/11457 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Receptor-interacting serine/threonine-protein kinase 4
component: Ras-related protein Rab-36

GTPase HRas
type: Protein
cellular location: Cytosol
entity reference: GTPase HRas

ReactionCatalysis37448
type: Catalysis
controller: STE20-like serine/threonine-protein kinase
controlled: 2.7.11.1
control type: ACTIVATION

ReactionCatalysis37447
type: Catalysis
controller: GRB2-SOS-IRS-SHC complex
controlled: Reaction47304
control type: ACTIVATION

Insulin receptor substrate 1
type: Protein
cellular location: Cytoplasm
entity reference: Insulin receptor substrate 1

GRB2-SOS-IRS-SHC complex
type: Complex
component stoichiometry: Protein/11456 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/11449 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/7725 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/11455 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Unknown
component: Insulin receptor substrate 4
component: Ras-GEF domain-containing family member 1B
component: Endophilin-A3

Ras-GEF domain-containing family member 1B
type: Protein
cellular location: Cell Membrane
entity reference: Ras-GEF domain-containing family member 1B

ProteinComplex/11140 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Activated Phosphatidylinositol 4,5-bisphosphate 3-kinase complex
stoichiometric coefficient: 1.0

Ras-related protein Rab-36
type: Protein
cellular location: Cytosol
entity reference: Ras-related protein Rab-36

Reference/UniProt P01325
type: UnificationXref
id: P01325
db: UniProt

Reference/UniProt P35569
type: UnificationXref
id: P35569
db: UniProt

STE20-like serine/threonine-protein kinase
type: Protein
cellular location: Cytosol
entity reference: STE20-like serine/threonine-protein kinase

ReactionCatalysis164384
type: Catalysis
controller: Activated Phosphatidylinositol 4,5-bisphosphate 3-kinase complex
controlled: Reaction174128
control type: ACTIVATION

Protein/19653 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoinositide 3-kinase regulatory subunit 6
stoichiometric coefficient: 1.0

Protein/11459 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ribosomal protein S6 kinase alpha-6
stoichiometric coefficient: 1.0

Protein/19427 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: GTPase HRas
stoichiometric coefficient: 1.0

Insulin Signalling
type: Pathway
pathway order: PathwayEnzymeReaction/2117645
pathway order: PathwayEnzymeReaction/2117646
pathway order: PathwayEnzymeReaction/2117647
pathway order: PathwayEnzymeReaction/2117648
pathway order: PathwaySubPathway/109179
pathway order: PathwayEnzymeReaction/2117641
pathway order: PathwayEnzymeReaction/2117652
pathway order: PathwayEnzymeReaction/2117642
pathway order: PathwayEnzymeReaction/2117643
pathway order: PathwayEnzymeReaction/2117644
pathway order: PathwayTransport/2117653
pathway order: PathwayEnzymeReaction/2117638
pathway order: PathwayEnzymeReaction/2117649
pathway order: PathwayEnzymeReaction/2117639
pathway order: PathwaySubPathway/109181
pathway order: PathwaySubPathway/109180
pathway order: PathwayEnzymeReaction/2117650
pathway order: PathwayEnzymeReaction/2117640
pathway order: PathwayEnzymeReaction/2117651
pathway component: ReactionCatalysis37444
pathway component: ReactionCatalysis37446
pathway component: ReactionCatalysis37445
pathway component: ReactionCatalysis37448
pathway component: ReactionCatalysis37447
pathway component: 2.7.10.1
pathway component: Reaction47302
pathway component: Reaction47303
pathway component: Reaction47304
pathway component: 2.7.11.1
pathway component: Reaction174130
pathway component: Reaction47306
pathway component: SubPathwayControl109180
pathway component: 2.7.12.2
pathway component: SubPathwayControl109179
pathway component: Starch and Sucrose Metabolism
pathway component: ReactionCatalysis37452
pathway component: ReactionCatalysis164384
pathway component: ReactionCatalysis37451
pathway component: ReactionCatalysis37450
pathway component: Reaction174128
pathway component: Reaction173876
pathway component: ReactionCatalysis37449
pathway component: Transport884
pathway component: TransportCatalysis784
xref: Reference/SMPDB SMP0108142
xref: Reference/PathWhiz PW109183
organism: Mus musculus

PIP3(16:0/16:0)
type: SmallMolecule
cellular location: Cytoplasm
entity reference: PIP3(16:0/16:0)

Phosphatidylinositol 4-kinase beta
type: Protein
cellular location: Cytosol
entity reference: Phosphatidylinositol 4-kinase beta

Unknown
type: Protein
cellular location: Cell Membrane
entity reference: Unknown

Reference/TAXONOMY 10090
type: UnificationXref
id: 10090
db: TAXONOMY

Insulin receptor substrate 1
type: Protein
cellular location: Cytosol
entity reference: Insulin receptor substrate 1

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/CAS 2280-44-6
type: UnificationXref
id: 2280-44-6
db: CAS

GRB2-SOS-IRS-SHC complex
type: Complex
component stoichiometry: Protein/7725 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/11456 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/11449 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/11455 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Unknown
component: Ras-GEF domain-containing family member 1B
component: Endophilin-A3
component: Insulin receptor substrate 4

Reference/ChemSpider 24767909
type: UnificationXref
id: 24767909
db: ChemSpider

Reference/UniProt Q9WUT3
type: UnificationXref
id: Q9WUT3
db: UniProt

Protein/19427 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: GTPase HRas
stoichiometric coefficient: 1.0

Starch and Sucrose Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway109181
pathway component: SubPathwayInteraction109181
xref: Reference/SMPDB SMP0000058
xref: Reference/PathWhiz PW000150
name: SubPathway

Reference/PathWhiz PW109183
type: UnificationXref
id: PW109183
db: PathWhiz

Protein/7725 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 1.0

ReactionCatalysis37452
type: Catalysis
controller: Ribosomal protein S6 kinase alpha-2
controlled: 2.7.12.2
control type: ACTIVATION

Reference/UniProt Q8K323
type: UnificationXref
id: Q8K323
db: UniProt

2.7.10.1
type: BiochemicalReaction
participant stoichiometry: Protein/11449 Cytosol/Stoichiometry/1.0
right: Insulin receptor substrate 4
spontaneous: false
EC number: 2.7.10.1
left: Insulin receptor substrate 4
name: Insulin receptor substrate 1 → Insulin receptor substrate 1 with Phosphorylation
conversion direction: LEFT_TO_RIGHT

Protein/19657 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Insulin receptor substrate 1
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6830
type: UnificationXref
id: 6830
db: PubChem-compound

ReactionCatalysis37451
type: Catalysis
controller: Ribosomal protein S6 kinase alpha-6
controlled: 2.7.12.2
control type: ACTIVATION

Reference/PathWhiz PW000150
type: UnificationXref
id: PW000150
db: PathWhiz

Guanosine diphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001201
xref: Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
xref: Reference/CAS 146-91-8
xref: Reference/PubChem-compound 8977
xref: Reference/ChEBI CHEBI 17552
xref: Reference/ChemSpider 8630
xref: Reference/KEGG Compound C00035
chemical formula: C10H15N5O11P2
molecular weight: 443.02432
structure: ChemicalStructure/PW C000936

ReactionCatalysis37450
type: Catalysis
controller: RAF proto-oncogene serine/threonine-protein kinase recruited by GTPase HRas
controlled: 2.7.11.1
control type: ACTIVATION

Protein/11456 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ras-GEF domain-containing family member 1B
stoichiometric coefficient: 1.0

Compound/PW C006073 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: PIP2(16:0/16:0)
stoichiometric coefficient: 1.0

Protein/11449 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Insulin receptor substrate 4
stoichiometric coefficient: 1.0

Ras-GEF domain-containing family member 1B
type: Protein
cellular location: Cytosol
entity reference: Ras-GEF domain-containing family member 1B

SubPathwayInteraction109181
type: Interaction
name: SubPathwayReaction
name: SubPathway109181Reaction
participant: D-Glucose

Insulin receptor substrate 4
type: ProteinReference
xref: Reference/UniProt Q9Z0Y7
organism: Mus musculus

ReactionCatalysis37449
type: Catalysis
controller: RAF proto-oncogene serine/threonine-protein kinase recruited by GTPase HRas
controlled: 2.7.11.1
control type: ACTIVATION

Mus musculus
type: BioSource
xref: Reference/TAXONOMY 10090

Solute carrier family 2, facilitated glucose transporter member 12
type: ProteinReference
xref: Reference/UniProt Q8BFW9

Ras-related protein Rab-36
type: Protein
cellular location: Cell Membrane
entity reference: Ras-related protein Rab-36

Phosphoinositide 3-kinase regulatory subunit 5
type: ProteinReference
xref: Reference/UniProt Q5SW28
organism: Mus musculus

Phosphatidylinositol 4-kinase beta
type: ProteinReference
xref: Reference/UniProt Q8BKC8
organism: Mus musculus

Guanosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15996
xref: Reference/ChemSpider 6569
xref: Reference/KEGG Compound C00044
xref: Reference/PubChem-compound 6830
xref: Reference/HMDB HMDB0001273
xref: Reference/CAS 86-01-1
xref: Reference/BioCyc GTP
chemical formula: C10H16N5O14P3
molecular weight: 522.99066
structure: ChemicalStructure/PW C000986

Guanosine triphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Guanosine triphosphate

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/UniProt B9EJW3
type: UnificationXref
id: B9EJW3
db: UniProt

ProteinComplex/5249 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: GRB2-IRS-SHC complex
stoichiometric coefficient: 1.0

Reaction174130
type: BiochemicalReaction
participant stoichiometry: Protein/11450 Cytosol/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/10414 Cytosol/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/11140 Cytosol/Stoichiometry/1.0
right: Activated Phosphatidylinositol 4,5-bisphosphate 3-kinase complex
spontaneous: true
left: Ras-related protein Rab-36
left: Phosphatidylinositol 4,5-bisphosphate 3-kinase complex
name: GTPase HRas with GTP + Phosphatidylinositol 4,5-bisphosphate 3-kinase complex → Activated Phosphatidylinositol 4,5-bisphosphate 3-kinase complex
conversion direction: LEFT_TO_RIGHT

Reference/UniProt Q62407
type: UnificationXref
id: Q62407
db: UniProt

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

D-Glucose
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000122
xref: Reference/PubChem-compound 5793
xref: Reference/CAS 2280-44-6
xref: Reference/ChemSpider 5589
xref: Reference/ChEBI CHEBI 4167
xref: Reference/BioCyc GLC
xref: Reference/KEGG Compound C00031
chemical formula: C6H12O6
molecular weight: 180.06339
structure: ChemicalStructure/PW C000077

Protein/11451 Extracellular Space/Stoichiometry/2.0
type: Stoichiometry
physical entity: Insulin-1
stoichiometric coefficient: 2.0

Reference/BioCyc Phosphatidylinositols
type: UnificationXref
id: Phosphatidylinositols
db: BioCyc

Compound/PW C000077 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glucose
stoichiometric coefficient: 1.0

Reference/PubChem-compound 53480223
type: UnificationXref
id: 53480223
db: PubChem-compound

Reference/BioCyc GLC
type: UnificationXref
id: GLC
db: BioCyc

Reference/UniProt Q80V09
type: UnificationXref
id: Q80V09
db: UniProt

GRB2-IRS-SHC complex
type: Complex
component stoichiometry: Protein/7725 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/11449 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/11455 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Unknown
component: Endophilin-A3
component: Insulin receptor substrate 4

Reference/UniProt Q8JZL7
type: UnificationXref
id: Q8JZL7
db: UniProt

Reference/HMDB HMDB0010147
type: UnificationXref
id: HMDB0010147
db: HMDB

ChemicalStructure/PW C000936
type: ChemicalStructure
structure format: SMILES

Insulin receptor activation by insulin
type: Pathway
name: ActivatingSubPathway

TBC domain-containing protein kinase-like protein
type: Protein
cellular location: Cell Membrane
entity reference: TBC domain-containing protein kinase-like protein
name: SubPathwayActivation

Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
type: UnificationXref
id: GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
db: BioCyc

Receptor-interacting serine/threonine-protein kinase 4
type: Protein
cellular location: Cell Membrane
entity reference: Receptor-interacting serine/threonine-protein kinase 4

Ribosomal protein S6 kinase alpha-6
type: Protein
cellular location: Cytosol
entity reference: Ribosomal protein S6 kinase alpha-6

Reaction174128
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006073 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006188 Cytoplasm/Stoichiometry/1.0
right: PIP3(16:0/16:0)
spontaneous: false
left: PIP2(16:0/16:0)
name: PIP2(16:0/16:0) → PIP3(16:0/16:0)
conversion direction: LEFT_TO_RIGHT

Reference/SMPDB SMP0000058
type: UnificationXref
id: SMP0000058
db: SMPDB

GLUT4 activation by AKT
type: Pathway
name: ActivatingSubPathway

PIP3(16:0/16:0)
type: SmallMoleculeReference
xref: Reference/BioCyc Phosphatidylinositols
xref: Reference/KEGG Compound C00626
xref: Reference/HMDB HMDB0010147
xref: Reference/ChemSpider 24768024
chemical formula: C41H82O22P4
molecular weight: 1050.4248
structure: ChemicalStructure/PW C006188

Reference/HMDB HMDB0010032
type: UnificationXref
id: HMDB0010032
db: HMDB

Reference/UniProt O54988
type: UnificationXref
id: O54988
db: UniProt

Reference/UniProt Q62421
type: UnificationXref
id: Q62421
db: UniProt

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/HMDB HMDB0001201
type: UnificationXref
id: HMDB0001201
db: HMDB

Insulin-1
type: Protein
cellular location: Extracellular Space
entity reference: Insulin-1

Protein/11450 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ras-related protein Rab-36
stoichiometric coefficient: 1.0

Activated Phosphatidylinositol 4,5-bisphosphate 3-kinase complex
type: Complex
component stoichiometry: Protein/19657 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/19660 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/19652 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/19653 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/19427 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Insulin receptor substrate 2
component: Insulin receptor substrate 1
component: Phosphoinositide 3-kinase regulatory subunit 6
component: GTPase HRas
component: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Striated muscle-specific serine/threonine-protein kinase
type: Protein
cellular location: Cytosol
entity reference: Striated muscle-specific serine/threonine-protein kinase

Reference/ChEBI CHEBI 15996
type: UnificationXref
id: CHEBI:15996
db: ChEBI

Reference/UniProt Q5SW28
type: UnificationXref
id: Q5SW28
db: UniProt

Insulin
type: Complex
component stoichiometry: Protein/11451 Extracellular Space/Stoichiometry/2.0
cellular location: Extracellular Space
component: Insulin-1
name: SubPathwayActivator

Insulin receptor substrate 2
type: Protein
cellular location: Cytosol
entity reference: Insulin receptor substrate 2

Endophilin-A3
type: Protein
cellular location: Cell Membrane
entity reference: Endophilin-A3

Reference/HMDB HMDB0000122
type: UnificationXref
id: HMDB0000122
db: HMDB

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

ProteinComplex/5256 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: RAF proto-oncogene serine/threonine-protein kinase recruited by GTPase HRas
stoichiometric coefficient: 1.0

Phosphatidylinositol 4,5-bisphosphate 3-kinase
type: Complex
component stoichiometry: Protein/11447 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/11448 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Phosphatidylinositol 4-kinase beta
component: Phosphoinositide 3-kinase regulatory subunit 5

Guanosine diphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Guanosine diphosphate

Reference/UniProt Q811B9
type: UnificationXref
id: Q811B9
db: UniProt

Reference/UniProt Q8BKC8
type: UnificationXref
id: Q8BKC8
db: UniProt

PIP2(16:0/16:0)
type: SmallMolecule
cellular location: Cytoplasm
entity reference: PIP2(16:0/16:0)

Phosphoinositide 3-kinase regulatory subunit 5
type: Protein
cellular location: Cytosol
entity reference: Phosphoinositide 3-kinase regulatory subunit 5

Reference/KEGG Compound C00031
type: UnificationXref
id: C00031
db: KEGG Compound

GTPase HRas
type: Protein
cellular location: Cytoplasm
entity reference: GTPase HRas

Reference/UniProt Q8CAM5
type: UnificationXref
id: Q8CAM5
db: UniProt

Protein/11455 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Endophilin-A3
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00035
type: UnificationXref
id: C00035
db: KEGG Compound

Phosphoinositide 3-kinase regulatory subunit 6
type: ProteinReference
xref: Reference/UniProt Q8K323
organism: Mus musculus

D-Glucose
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Glucose

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: ProteinReference
xref: Reference/UniProt Q80V09
organism: Mus musculus

Insulin receptor substrate 1
type: ProteinReference
xref: Reference/UniProt P35569
organism: Mus musculus

D-Glucose
type: SmallMolecule
cellular location: Extracellular Space
entity reference: D-Glucose

Reference/KEGG Compound C00044
type: UnificationXref
id: C00044
db: KEGG Compound

Reference/ChemSpider 24768024
type: UnificationXref
id: 24768024
db: ChemSpider

Reference/SMPDB SMP0108142
type: UnificationXref
id: SMP0108142
db: SMPDB

Insulin receptor substrate 2
type: ProteinReference
xref: Reference/UniProt B9EJW3
organism: Mus musculus

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Reaction173876
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/5241 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/11449 Cytosol/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/10414 Cytosol/Stoichiometry/1.0
right: Phosphatidylinositol 4,5-bisphosphate 3-kinase complex
spontaneous: true
left: Phosphatidylinositol 4,5-bisphosphate 3-kinase
left: Insulin receptor substrate 4
name: Insulin receptor substrate 1 with Phosphorylation + Insulin receptor substrate 2 with Phosphorylation + Phosphatidylinositol 4,5-bisphosphate 3-kinase → Phosphatidylinositol 4,5-bisphosphate 3-kinase complex
conversion direction: LEFT_TO_RIGHT

Reference/UniProt Q7TPS0
type: UnificationXref
id: Q7TPS0
db: UniProt

Transport884
type: Transport
participant stoichiometry: Compound/PW C000077 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000077 Extracellular Space/Stoichiometry/1.0
right: D-Glucose
spontaneous: false
left: D-Glucose
name: D-Glucose (→) Transport: Mus musculus, Extracellular Space to Mus musculus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

GTPase HRas
type: ProteinReference
xref: Reference/UniProt Q811B9
organism: Mus musculus

Compound/PW C000986 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine triphosphate
stoichiometric coefficient: 1.0

Tyrosine-protein kinase Srms
type: Protein
cellular location: Cytosol
entity reference: Tyrosine-protein kinase Srms

Solute carrier family 2, facilitated glucose transporter member 12
type: Protein
entity reference: Solute carrier family 2, facilitated glucose transporter member 12

Protein/11448 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoinositide 3-kinase regulatory subunit 5
stoichiometric coefficient: 1.0

Reference/ChemSpider 5589
type: UnificationXref
id: 5589
db: ChemSpider

Phosphoinositide 3-kinase regulatory subunit 6
type: Protein
cellular location: Cytosol
entity reference: Phosphoinositide 3-kinase regulatory subunit 6

Protein/7725 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 1.0

ProteinComplex/10414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol 4,5-bisphosphate 3-kinase complex
stoichiometric coefficient: 1.0

Reference/UniProt Q9ERK0
type: UnificationXref
id: Q9ERK0
db: UniProt

Ribosomal protein S6 kinase alpha-2
type: Protein
cellular location: Cell Membrane
entity reference: Ribosomal protein S6 kinase alpha-2

Protein/11447 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol 4-kinase beta
stoichiometric coefficient: 1.0

PIP2(16:0/16:0)
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0010032
xref: Reference/BioCyc Phosphatidylinositols
xref: Reference/PubChem-compound 53480223
xref: Reference/KEGG Compound C00626
xref: Reference/ChemSpider 24767909
chemical formula: C41H81O19P3
molecular weight: 970.4585
structure: ChemicalStructure/PW C006073

Protein/19657 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Insulin receptor substrate 1
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00626
type: UnificationXref
id: C00626
db: KEGG Compound

Unknown
type: ProteinReference
organism: Mus musculus

Protein/11449 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Insulin receptor substrate 4
stoichiometric coefficient: 1.0

Reference/UniProt Q8BM85
type: UnificationXref
id: Q8BM85
db: UniProt

Reference/PubChem-compound 8977
type: UnificationXref
id: 8977
db: PubChem-compound

Compound/PW C000077 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glucose
stoichiometric coefficient: 1.0

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: Protein
cellular location: Cytoplasm
entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Phosphatidylinositol 4,5-bisphosphate 3-kinase complex
type: Complex
component stoichiometry: Protein/19660 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/19652 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/19653 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/19657 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Phosphoinositide 3-kinase regulatory subunit 6
component: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
component: Insulin receptor substrate 1
component: Insulin receptor substrate 2

Ribosomal protein S6 kinase alpha-6
type: Protein
cellular location: Cell Membrane
entity reference: Ribosomal protein S6 kinase alpha-6

STE20-like serine/threonine-protein kinase
type: ProteinReference
xref: Reference/UniProt O54988
organism: Mus musculus

TBC domain-containing protein kinase-like protein
type: ProteinReference
xref: Reference/UniProt Q8BM85
organism: Mus musculus

Endophilin-A3
type: ProteinReference
xref: Reference/UniProt Q62421
organism: Mus musculus

Striated muscle-specific serine/threonine-protein kinase
type: ProteinReference
xref: Reference/UniProt Q62407
organism: Mus musculus

Insulin-1
type: ProteinReference
xref: Reference/UniProt P01325
organism: Mus musculus

Ras-related protein Rab-36
type: ProteinReference
xref: Reference/UniProt Q8CAM5
organism: Mus musculus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: Protein
cellular location: Cytosol
entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

2.7.10.1
type: BiochemicalReaction
participant stoichiometry: Protein/11449 Cytosol/Stoichiometry/1.0
right: Insulin receptor substrate 4
spontaneous: false
EC number: 2.7.10.1
left: Insulin receptor substrate 4
name: Insulin receptor substrate 2 → Insulin receptor substrate 2 with Phosphorylation
conversion direction: LEFT_TO_RIGHT

2.7.10.1
type: BiochemicalReaction
participant stoichiometry: Protein/7725 Cytosol/Stoichiometry/1.0
right: Unknown
spontaneous: false
EC number: 2.7.10.1
left: Unknown
name: SHC-transforming protein 1 → SHC-transforming protein 1 with phosphorylation
conversion direction: LEFT_TO_RIGHT

Phosphoinositide 3-kinase regulatory subunit 6
type: Protein
cellular location: Cytoplasm
entity reference: Phosphoinositide 3-kinase regulatory subunit 6

Reaction47302
type: BiochemicalReaction
participant stoichiometry: Protein/7725 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/11449 Cytosol/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/5249 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/11455 Cytosol/Stoichiometry/1.0
right: GRB2-IRS-SHC complex
spontaneous: true
left: Unknown
left: Endophilin-A3
left: Insulin receptor substrate 4
name: Growth factor receptor-bound protein 2 + Insulin receptor substrate 1 with Phosphorylation + SHC-transforming protein 1 with phosphorylation → GRB2-IRS-SHC complex
conversion direction: LEFT_TO_RIGHT

ProteinComplex/5251 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: GRB2-SOS-IRS-SHC complex
stoichiometric coefficient: 1.0

Reaction47303
type: BiochemicalReaction
participant stoichiometry: Protein/11456 Cytosol/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/5251 Cytosol/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/5249 Cytosol/Stoichiometry/1.0
right: GRB2-SOS-IRS-SHC complex
spontaneous: true
left: Ras-GEF domain-containing family member 1B
left: GRB2-IRS-SHC complex
name: GRB2-IRS-SHC complex + Son of sevenless homolog 1 → GRB2-SOS-IRS-SHC complex
conversion direction: LEFT_TO_RIGHT

Reaction47304
type: BiochemicalReaction
participant stoichiometry: Protein/11450 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000936 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000986 Cell Membrane/Stoichiometry/1.0
right: Guanosine diphosphate
right: Ras-related protein Rab-36
spontaneous: false
left: Guanosine triphosphate
left: Ras-related protein Rab-36
name: GTPase HRas with GDP + Guanosine triphosphate → GTPase HRas with GTP + Guanosine diphosphate
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 8630
type: UnificationXref
id: 8630
db: ChemSpider

Protein/11455 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Endophilin-A3
stoichiometric coefficient: 1.0

2.7.11.1
type: BiochemicalReaction
participant stoichiometry: Protein/11454 Cytosol/Stoichiometry/1.0
right: Striated muscle-specific serine/threonine-protein kinase
spontaneous: false
EC number: 2.7.11.1
left: Striated muscle-specific serine/threonine-protein kinase
name: RAC-alpha serine/threonine-protein kinase → RAC-alpha serine/threonine-protein kinase with phosphorylation
conversion direction: LEFT_TO_RIGHT

Reaction47306
type: BiochemicalReaction
participant stoichiometry: Protein/11450 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/5256 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Protein/11457 Cell Membrane/Stoichiometry/1.0
right: RAF proto-oncogene serine/threonine-protein kinase recruited by GTPase HRas
spontaneous: true
left: Receptor-interacting serine/threonine-protein kinase 4
left: Ras-related protein Rab-36
name: GTPase HRas with GTP + RAF proto-oncogene serine/threonine-protein kinase → RAF proto-oncogene serine/threonine-protein kinase recruited by GTPase HRas
conversion direction: LEFT_TO_RIGHT

2.7.11.1
type: BiochemicalReaction
participant stoichiometry: Protein/11458 Cell Membrane/Stoichiometry/1.0
right: Ribosomal protein S6 kinase alpha-2
spontaneous: false
EC number: 2.7.11.1
left: Ribosomal protein S6 kinase alpha-2
name: Inactive Dual specificity mitogen-activated protein kinase kinase 1 → Active Dual specificity mitogen-activated protein kinase kinase 1
conversion direction: LEFT_TO_RIGHT

Protein/11454 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Striated muscle-specific serine/threonine-protein kinase
stoichiometric coefficient: 1.0

2.7.11.1
type: BiochemicalReaction
participant stoichiometry: Protein/11459 Cell Membrane/Stoichiometry/1.0
right: Ribosomal protein S6 kinase alpha-6
spontaneous: false
EC number: 2.7.11.1
left: Ribosomal protein S6 kinase alpha-6
name: Inactive Dual specificity mitogen-activated protein kinase kinase 2 → Active Dual specificity mitogen-activated protein kinase kinase 2
conversion direction: LEFT_TO_RIGHT

Unknown
type: Protein
cellular location: Cytosol
entity reference: Unknown

2.7.12.2
type: BiochemicalReaction
participant stoichiometry: Protein/11460 Cytosol/Stoichiometry/1.0
right: Tyrosine-protein kinase Srms
spontaneous: false
EC number: 2.7.12.2
left: Tyrosine-protein kinase Srms
name: Inactive Mitogen-activated protein kinase 1 → Active Mitogen-activated protein kinase 1
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C006073
type: ChemicalStructure
structure format: SMILES

Receptor-interacting serine/threonine-protein kinase 4
type: ProteinReference
xref: Reference/UniProt Q9ERK0
organism: Mus musculus

Protein/19653 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoinositide 3-kinase regulatory subunit 6
stoichiometric coefficient: 1.0

TBC domain-containing protein kinase-like protein
type: Protein
cellular location: Cytosol
entity reference: TBC domain-containing protein kinase-like protein

Ras-GEF domain-containing family member 1B
type: ProteinReference
xref: Reference/UniProt Q8JZL7
organism: Mus musculus

Ribosomal protein S6 kinase alpha-6
type: ProteinReference
xref: Reference/UniProt Q7TPS0
organism: Mus musculus

Ribosomal protein S6 kinase alpha-2
type: ProteinReference
xref: Reference/UniProt Q9WUT3
organism: Mus musculus

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Protein/11460 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tyrosine-protein kinase Srms
stoichiometric coefficient: 1.0

Insulin receptor substrate 2
type: Protein
cellular location: Cytoplasm
entity reference: Insulin receptor substrate 2

Striated muscle-specific serine/threonine-protein kinase
type: Protein
cellular location: Cytoplasm
entity reference: Striated muscle-specific serine/threonine-protein kinase
name: SubPathwayActivator

Tyrosine-protein kinase Srms
type: ProteinReference
xref: Reference/UniProt Q62270
organism: Mus musculus

Reference/UniProt Q9Z0Y7
type: UnificationXref
id: Q9Z0Y7
db: UniProt

Protein/19652 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
stoichiometric coefficient: 1.0

Reference/ChemSpider 6569
type: UnificationXref
id: 6569
db: ChemSpider

2.7.12.2
type: BiochemicalReaction
participant stoichiometry: Protein/11460 Cytosol/Stoichiometry/1.0
right: Tyrosine-protein kinase Srms
spontaneous: false
EC number: 2.7.12.2
left: Tyrosine-protein kinase Srms
name: Inactive Mitogen-activated protein kinase 1 → Active Mitogen-activated protein kinase 1
conversion direction: LEFT_TO_RIGHT

Endophilin-A3
type: Protein
cellular location: Cytosol
entity reference: Endophilin-A3

Protein/19652 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17552
type: UnificationXref
id: CHEBI:17552
db: ChEBI

Reference/BioCyc GTP
type: UnificationXref
id: GTP
db: BioCyc

Protein/19660 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Insulin receptor substrate 2
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 4167
type: UnificationXref
id: CHEBI:4167
db: ChEBI

Solute carrier family 2, facilitated glucose transporter member 12
type: Protein
cellular location: Cell Membrane
entity reference: Solute carrier family 2, facilitated glucose transporter member 12
name: SubPathwayActivation

Reference/HMDB HMDB0001273
type: UnificationXref
id: HMDB0001273
db: HMDB

Activated Phosphatidylinositol 4,5-bisphosphate 3-kinase complex
type: Complex
component stoichiometry: Protein/19660 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/19652 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/19653 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/19657 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/19427 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: GTPase HRas
component: Phosphoinositide 3-kinase regulatory subunit 6
component: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
component: Insulin receptor substrate 1
component: Insulin receptor substrate 2

Reference/PubChem-compound 5793
type: UnificationXref
id: 5793
db: PubChem-compound

ChemicalStructure/PW C000986
type: ChemicalStructure
structure format: SMILES

SubPathwayControl109180
type: Interaction
name: SubPathway109180Control
name: ActivatingSubPathwayControl
participant: Striated muscle-specific serine/threonine-protein kinase
participant: GLUT4 activation by AKT
participant: Solute carrier family 2, facilitated glucose transporter member 12

ChemicalStructure/PW C000077
type: ChemicalStructure
structure format: SMILES
structure data: OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O

Protein/11450 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ras-related protein Rab-36
stoichiometric coefficient: 1.0

Protein/11456 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ras-GEF domain-containing family member 1B
stoichiometric coefficient: 1.0

SubPathwayControl109179
type: Interaction
name: SubPathway109179Control
name: ActivatingSubPathwayControl
participant: TBC domain-containing protein kinase-like protein
participant: Insulin
participant: Insulin receptor activation by insulin

Reference/CAS 86-01-1
type: UnificationXref
id: 86-01-1
db: CAS

Insulin receptor substrate 4
type: Protein
cellular location: Cytosol
entity reference: Insulin receptor substrate 4

Insulin receptor substrate 4
type: Protein
cellular location: Cell Membrane
entity reference: Insulin receptor substrate 4

D-Glucose
type: SmallMolecule
cellular location: Cytoplasm
entity reference: D-Glucose
name: SubPathwayInput

Reference/UniProt Q8BFW9
type: UnificationXref
id: Q8BFW9
db: UniProt

Ribosomal protein S6 kinase alpha-2
type: Protein
cellular location: Cytosol
entity reference: Ribosomal protein S6 kinase alpha-2

Compound/PW C006188 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: PIP3(16:0/16:0)
stoichiometric coefficient: 1.0

Compound/PW C000936 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine diphosphate
stoichiometric coefficient: 1.0

Reference/CAS 146-91-8
type: UnificationXref
id: 146-91-8
db: CAS

ChemicalStructure/PW C006188
type: ChemicalStructure
structure format: SMILES

Protein/11457 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Receptor-interacting serine/threonine-protein kinase 4
stoichiometric coefficient: 1.0

TransportCatalysis784
type: Catalysis
controller: Solute carrier family 2, facilitated glucose transporter member 12
controlled: Transport884
control type: ACTIVATION

Reference/UniProt Q62270
type: UnificationXref
id: Q62270
db: UniProt