1.0
PW109202
PathWhiz
1.0
127983
ChemSpider
ReactionCatalysis164396
ACTIVATION
ReactionCatalysis164391
ACTIVATION
Nitric oxide synthase, endothelial
direct_interaction
Q9DBQ3
UniProt
1.0
cGMP-dependent protein kinase 1
Potassium voltage-gated channel subfamily KQT member 3
Calcium
Nitric oxide
Potassium voltage-gated channel subfamily KQT member 4
cGMP-dependent protein kinase 2
Potassium voltage-gated channel subfamily KQT member 2
1.0
Potassium voltage-gated channel subfamily KQT member 5
HMDB0000250
HMDB
SMILES
[O-]P([O-])(=O)OP([O-])([O-])=O
14000-31-8
CAS
Q9ES76
UniProt
HMDB0000538
HMDB
C00044
KEGG Compound
1.0
ATP
BioCyc
NITRIC-OXIDE
BioCyc
cAMP
HMDB0003378
HMDB
Cyclic GMP
C10H12N5O7P
Cyclic GMP
345.04742
559142
ChemSpider
Cytoplasm
C10H12N5O6P
cAMP
329.05252
CHEBI:16356
ChEBI
CHEBI:15422
ChEBI
10090
TAXONOMY
1.0
Q61410
UniProt
CGMP
BioCyc
5742
ChemSpider
Q9Z0Z0
UniProt
C00575
KEGG Compound
cGMP-dependent protein kinase 2
1.0
2.0
Guanosine triphosphate
Guanylate cyclase soluble subunit beta-1
C10H16N5O13P3
Adenosine triphosphate
506.99576
3.0
Interaction1051
3 Calcium activates Nitric-oxide synthase, endothelial
Cyclic GMP
E9QJY5
UniProt
CHEBI:16480
ChEBI
Interaction1055
cGMP-dependent protein kinase inhibits Potassium voltage-gated channel, KQT-like subfamily
Interaction1296
Cyclic GMP activates cGMP-dependent protein kinase
Interaction1295
cAMP activates Transient receptor potential cation channel
5851
ChemSpider
Interaction1052
Cyclic GMP activates Transient receptor potential cation channel
NO
Nitric oxide
29.997988
6830
PubChem-compound
Pyrophosphate
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@@H]2COP(O)(=O)O[C@H]2[C@H]1O
266
ChemSpider
Ion Channels and Their Functional Role in Vascular Endothelium
PPI
BioCyc
SMILES
NC1=NC2=C(N=CN2[C@@H]2O[C@@H]3COP(O)(=O)O[C@H]3[C@H]2O)C(=O)N1
1.0
Mus musculus
1.0
C10H16N5O14P3
Guanosine triphosphate
522.99066
Q7TSV7
UniProt
Q9Z350
UniProt
1.0
145068
PubChem-compound
Nitric oxide
Q9WVC5
UniProt
C00076
KEGG Compound
1.0
CA%2b2
BioCyc
HMDB0000058
HMDB
1.0
Ca
Calcium
39.96259
Q8C9Y6
UniProt
Q8BSF6
UniProt
Potassium voltage-gated channel subfamily KQT member 4
cGMP-dependent protein kinase 1
Potassium voltage-gated channel subfamily KQT member 5
6569
ChemSpider
SMILES
[N]=O
Soluble guanylyl cyclase
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
CHEBI:18361
ChEBI
271
PubChem-compound
GTP
BioCyc
1.0
1.0
C00002
KEGG Compound
HMDB0000464
HMDB
Interaction1359
Nitric oxide activates Soluble guanylyl cyclase
Potassium voltage-gated channel subfamily KQT member 2
HMDB0001314
HMDB
Transport9379
false
Calcium (→) Transport: Mus musculus, Extracellular Space to Mus musculus, Cell, Cytoplasm
LEFT_TO_RIGHT
cGMP-dependent protein kinase
2.0
HMDB0001273
HMDB
24316
PubChem-compound
Potassium voltage-gated channel subfamily KQT member 3
Guanylate cyclase soluble subunit alpha-1
Q9QZC0
UniProt
Reaction174154
false
Nitric-oxide synthase, endothelial → Nitric oxide
LEFT_TO_RIGHT
Reaction174155
false
Guanosine triphosphate → Cyclic GMP
LEFT_TO_RIGHT
644102
PubChem-compound
CHEBI:17489
ChEBI
1.0
1.0
CAMP
BioCyc
Q61058
UniProt
Adenosine triphosphate
SMILES
NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1
O54865
UniProt
cGMP-dependent protein kinase 1
Adenylate cyclase type 10
C00533
KEGG Compound
3.0
C00013
KEGG Compound
Extracellular Space
cGMP-dependent protein kinase 2
22734
ChemSpider
Transient receptor potential cation channel subfamily V member 4
O7P2
Pyrophosphate
173.91193
SMP0108160
SMPDB
1.0
10102-43-9
CAS
Calcium
1.0
5957
PubChem-compound
14127-61-8
CAS
SMILES
[Ca++]
Nitric oxide synthase, endothelial
86-01-1
CAS
Short transient receptor potential channel 3
Adenylate cyclase type 10
Transient receptor potential cation channel
cGMP-dependent protein kinase
Reaction174144
false
Adenosine triphosphate → Pyrophosphate + cAMP
LEFT_TO_RIGHT
6076
PubChem-compound
C00942
KEGG Compound
1.0
Q3V0F8
UniProt
CHEBI:15996
ChEBI
Calcium
Nitric-oxide synthase, endothelial
Potassium voltage-gated channel, KQT-like subfamily
56-65-5
CAS
Short transient receptor potential channel 4
Short transient receptor potential channel 7
Guanylate cyclase soluble subunit beta-1
Short transient receptor potential channel 3
GO:0005615
GENE ONTOLOGY
GO:0005737
GENE ONTOLOGY
1.0
CHEBI:29108
ChEBI
Short transient receptor potential channel 4
60-92-4
CAS
Guanylate cyclase soluble subunit alpha-1
Transient receptor potential cation channel subfamily V member 4
TransportCatalysis1150
ACTIVATION
Short transient receptor potential channel 7
cAMP
7665-99-8
CAS