Protein/19358/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit beta
stoichiometric coefficient: 1.0

Protein/19489 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ribosomal protein S6 kinase beta-1
stoichiometric coefficient: 1.0

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: Protein
cellular location: Cell Membrane
entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

cAMP
type: SmallMolecule
cellular location: Cytosol
entity reference: cAMP
name: SubPathwayInput

BCL2 associated agonist of cell death
type: ProteinReference
xref: Reference/UniProt F1MUT9
organism: Bos taurus

Protein/19493 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: BCL2 associated agonist of cell death
stoichiometric coefficient: 1.0

Reference/UniProt O18957
type: UnificationXref
id: O18957
db: UniProt

ProteinComplex/11209 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dual specificity mitogen-activated protein kinase kinase 6
stoichiometric coefficient: 1.0

Cyclic AMP-responsive element-binding protein 1
type: ProteinReference
xref: Reference/UniProt O18957
organism: Bos taurus

Reaction2109
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006188 Cytosol/Stoichiometry/1.0
right: PIP3(16:0/16:0)
spontaneous: false
left: PIP3(16:0/16:0)
name: PIP3(16:0/16:0) → PIP3(16:0/16:0)
conversion direction: LEFT_TO_RIGHT

Reference/UniProt Q95KV0
type: UnificationXref
id: Q95KV0
db: UniProt

Reference/UniProt Q2KIC2
type: UnificationXref
id: Q2KIC2
db: UniProt

Adenosine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 60961
xref: Reference/ChEBI CHEBI 16335
xref: Reference/ChemSpider 54923
xref: Reference/HMDB HMDB0000050
xref: Reference/CAS 58-61-7
xref: Reference/KEGG Compound C00212
xref: Reference/BioCyc ADENOSINE
chemical formula: C10H13N5O4
molecular weight: 267.09674
structure: ChemicalStructure/PW C000034

Compound/PW C000041 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

Reference/TAXONOMY 9913
type: UnificationXref
id: 9913
db: TAXONOMY

cAMP-dependent protein kinase catalytic subunit beta
type: Protein
cellular location: Cell Membrane
entity reference: cAMP-dependent protein kinase catalytic subunit beta

Rho guanine nucleotide exchange factor 9
type: Protein
cellular location: Cytosol
entity reference: Rho guanine nucleotide exchange factor 9

Reaction174200
type: BiochemicalReaction
participant stoichiometry: Protein/19358/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006188/Stoichiometry/1.0
right: cAMP-dependent protein kinase catalytic subunit beta
right: PIP3(16:0/16:0)
spontaneous: false
left: cAMP-dependent protein kinase catalytic subunit beta
left: PIP3(16:0/16:0)
name: 3-phosphoinositide-dependent protein kinase 1 + PIP3(16:0/16:0) → 3-phosphoinositide-dependent protein kinase 1 + PIP3(16:0/16:0)
conversion direction: LEFT_TO_RIGHT

Protein/19514 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NF-kappa-B inhibitor zeta
stoichiometric coefficient: 1.0

Reaction174201
type: BiochemicalReaction
participant stoichiometry: Protein/19500 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006188 Cell Membrane/Stoichiometry/1.0
right: PIP3(16:0/16:0)
right: RAC-alpha serine/threonine-protein kinase
spontaneous: true
left: PIP3(16:0/16:0)
left: RAC-alpha serine/threonine-protein kinase
name: PIP3(16:0/16:0) + RAC-alpha serine/threonine-protein kinase → PIP3(16:0/16:0) + RAC-alpha serine/threonine-protein kinase
conversion direction: LEFT_TO_RIGHT

2.7.11.1
type: BiochemicalReaction
participant stoichiometry: Protein/19500 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006188 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
right: Phosphate
right: PIP3(16:0/16:0)
right: RAC-alpha serine/threonine-protein kinase
spontaneous: false
EC number: 2.7.11.1
left: PIP3(16:0/16:0)
left: RAC-alpha serine/threonine-protein kinase
name: PIP3(16:0/16:0) + RAC-alpha serine/threonine-protein kinase → PIP3(16:0/16:0) + Phosphate + RAC-alpha serine/threonine-protein kinase
conversion direction: LEFT_TO_RIGHT

2.7.11.1
type: BiochemicalReaction
participant stoichiometry: Protein/19509 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Protein/19503 Cell Membrane/Stoichiometry/1.0
right: Inhibitor of nuclear factor kappa-B kinase subunit alpha
right: Phosphate
right: Inhibitor of nuclear factor kappa-B kinase subunit beta
spontaneous: false
EC number: 2.7.11.1
left: Inhibitor of nuclear factor kappa-B kinase subunit alpha
left: Inhibitor of nuclear factor kappa-B kinase subunit beta
name: Inhibitor of nuclear factor kappa-B kinase subunit alpha + Inhibitor of nuclear factor kappa-B kinase subunit beta → Inhibitor of nuclear factor kappa-B kinase subunit alpha + Inhibitor of nuclear factor kappa-B kinase subunit beta + Phosphate
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/UniProt F1N177
type: UnificationXref
id: F1N177
db: UniProt

Guanine nucleotide-binding protein gamma-beta
type: Complex
component stoichiometry: Protein/19753 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/19350 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Guanine nucleotide-binding protein G(T) subunit gamma-T1
component: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Unknown
type: Protein
cellular location: Cytosol
entity reference: Unknown

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Adenosine receptor A2b
type: ProteinReference
xref: Reference/UniProt Q1LZD0
organism: Bos taurus

PIP3(16:0/16:0)
type: SmallMolecule
cellular location: Cell Membrane
entity reference: PIP3(16:0/16:0)

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

2.7.11.10
type: BiochemicalReaction
participant stoichiometry: Protein/19514 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: NF-kappa-B inhibitor zeta
spontaneous: false
EC number: 2.7.11.10
left: NF-kappa-B inhibitor zeta
name: NF-kappa-B inhibitor alpha → NF-kappa-B inhibitor alpha + Phosphate
conversion direction: LEFT_TO_RIGHT

Reaction174207
type: BiochemicalReaction
participant stoichiometry: Protein/19514 Cytosol/Stoichiometry/1.0
right: NF-kappa-B inhibitor zeta
spontaneous: true
left: NF-kappa-B inhibitor zeta
name: NF-kappa-B inhibitor alpha + Nuclear factor NF-kappa-B p100 subunit + Nuclear factor NF-kappa-B p105 subunit → NF-kappa-B inhibitor alpha + Nuclear factor NF-kappa-B p100 subunit + Nuclear factor NF-kappa-B p105 subunit
conversion direction: LEFT_TO_RIGHT

RAF proto-oncogene serine/threonine-protein kinase
type: Protein
cellular location: Cytosol
entity reference: RAF proto-oncogene serine/threonine-protein kinase

cAMP
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6076
xref: Reference/HMDB HMDB0000058
xref: Reference/ChEBI CHEBI 17489
xref: Reference/CAS 60-92-4
xref: Reference/BioCyc CAMP
xref: Reference/ChemSpider 5851
xref: Reference/KEGG Compound C00575
chemical formula: C10H12N5O6P
molecular weight: 329.05252
structure: ChemicalStructure/PW C000041

Protein/19379 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cyclic AMP-responsive element-binding protein 1
stoichiometric coefficient: 1.0

Protein/19485 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Protein kinase C beta type
stoichiometric coefficient: 1.0

Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Mitogen-activated protein kinase 1
type: Protein
cellular location: Cytosol
entity reference: Mitogen-activated protein kinase 1

Reference/KEGG Compound C00575
type: UnificationXref
id: C00575
db: KEGG Compound

Reference/KEGG Compound C00212
type: UnificationXref
id: C00212
db: KEGG Compound

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Rap guanine nucleotide exchange factor 2
type: ProteinReference
xref: Reference/UniProt F1MSG6
organism: Bos taurus

SubPathwayInteraction109197
type: Interaction
name: SubPathwayReaction
name: SubPathway109197Reaction
participant: cAMP

SubPathwayInteraction109196
type: Interaction
name: SubPathwayReaction
name: SubPathway109196Reaction
participant: cAMP

Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
type: Pathway
pathway order: PathwayEnzymeReaction/2117931
pathway order: PathwayEnzymeReaction/2117910
pathway order: PathwayEnzymeReaction/2117932
pathway order: PathwayEnzymeReaction/2117911
pathway order: PathwayEnzymeReaction/2117933
pathway order: PathwayEnzymeReaction/2117912
pathway order: PathwayEnzymeReaction/2117934
pathway order: PathwayEnzymeReaction/2117930
pathway order: PathwayEnzymeReaction/2117917
pathway order: PathwayEnzymeReaction/2117939
pathway order: PathwayTransport/2117951
pathway order: PathwayEnzymeReaction/2117918
pathway order: PathwayEnzymeReaction/2117919
pathway order: PathwayTransport/2117950
pathway order: PathwayEnzymeReaction/2117913
pathway order: PathwayEnzymeReaction/2117935
pathway order: PathwayEnzymeReaction/2117914
pathway order: PathwayEnzymeReaction/2117936
pathway order: PathwayEnzymeReaction/2117915
pathway order: PathwayEnzymeReaction/2117937
pathway order: PathwayEnzymeReaction/2117916
pathway order: PathwayEnzymeReaction/2117938
pathway order: PathwayEnzymeReaction/2117920
pathway order: PathwayEnzymeReaction/2117942
pathway order: PathwayEnzymeReaction/2117921
pathway order: PathwayEnzymeReaction/2117943
pathway order: PathwayEnzymeReaction/2117922
pathway order: PathwayEnzymeReaction/2117944
pathway order: PathwayEnzymeReaction/2117923
pathway order: PathwayEnzymeReaction/2117945
pathway order: PathwaySubPathway/109196
pathway order: PathwayEnzymeReaction/2117940
pathway order: PathwaySubPathway/109198
pathway order: PathwayEnzymeReaction/2117941
pathway order: PathwaySubPathway/109197
pathway order: PathwayEnzymeReaction/2117928
pathway order: PathwayEnzymeReaction/2117929
pathway order: PathwayEnzymeReaction/2117908
pathway order: PathwayEnzymeReaction/2117909
pathway order: PathwayEnzymeReaction/2117924
pathway order: PathwayEnzymeReaction/2117946
pathway order: PathwayEnzymeReaction/2117925
pathway order: PathwayEnzymeReaction/2117947
pathway order: PathwayEnzymeReaction/2117926
pathway order: PathwayEnzymeReaction/2117948
pathway order: PathwayEnzymeReaction/2117927
pathway order: PathwayEnzymeReaction/2117949
pathway component: Reaction174175
pathway component: ReactionCatalysis164436
pathway component: 2.7.12.2
pathway component: ReactionCatalysis164435
pathway component: ReactionCatalysis164438
pathway component: 2.7.11.24
pathway component: ReactionCatalysis164437
pathway component: 2.7.11.11
pathway component: Reaction174179
pathway component: ReactionCatalysis164432
pathway component: ReactionCatalysis164434
pathway component: ReactionCatalysis164430
pathway component: Reaction174172
pathway component: Reaction174173
pathway component: Reaction174174
pathway component: Transport10000
pathway component: Transport10001
pathway component: Reaction2109
pathway component: ReactionCatalysis164428
pathway component: ReactionCatalysis164425
pathway component: ReactionCatalysis164424
pathway component: ReactionCatalysis164427
pathway component: ReactionCatalysis164426
pathway component: Reaction174200
pathway component: Reaction174201
pathway component: ReactionCatalysis164420
pathway component: 2.7.11.1
pathway component: ReactionCatalysis164423
pathway component: ReactionCatalysis164422
pathway component: 2.7.11.10

Protein/19438 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cell division control protein 42 homolog
stoichiometric coefficient: 1.0

Protein/19350 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
stoichiometric coefficient: 1.0

Reference/ChemSpider 24767909
type: UnificationXref
id: 24767909
db: ChemSpider

Par-6 family cell polarity regulator alpha
type: Protein
cellular location: Cytosol
entity reference: Par-6 family cell polarity regulator alpha

SubPathwayInteraction109198
type: Interaction
name: SubPathwayReaction
name: SubPathway109198Reaction
participant: BCL2 associated agonist of cell death

Guanosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Guanosine triphosphate

TransportCatalysis1235
type: Catalysis
controller: Adenosine receptor A2b
controlled: Transport10000
control type: ACTIVATION

Guanosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Guanosine diphosphate

Phosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Phosphate

Compound/PW C000034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine
stoichiometric coefficient: 1.0

Reference/UniProt P32871
type: UnificationXref
id: P32871
db: UniProt

Protein/19500 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: RAC-alpha serine/threonine-protein kinase
stoichiometric coefficient: 1.0

Pyrophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyrophosphate

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: O4P
molecular weight: 94.95342
structure: ChemicalStructure/PW C001104

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: Protein
cellular location: Cytosol
entity reference: Inhibitor of nuclear factor kappa-B kinase subunit beta

Protein/19391 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine receptor A2b
stoichiometric coefficient: 1.0

Reference/ChemSpider 5851
type: UnificationXref
id: 5851
db: ChemSpider

Reference/PubChem-compound 6830
type: UnificationXref
id: 6830
db: PubChem-compound

Guanosine diphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001201
xref: Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
xref: Reference/CAS 146-91-8
xref: Reference/PubChem-compound 8977
xref: Reference/ChEBI CHEBI 17552
xref: Reference/ChemSpider 8630
xref: Reference/KEGG Compound C00035
chemical formula: C10H15N5O11P2
molecular weight: 443.02432
structure: ChemicalStructure/PW C000936

Mitogen-activated protein kinase 13
type: Protein
cellular location: Nucleus
entity reference: Mitogen-activated protein kinase 13

Protein/19430 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ras-related protein Rap-1b
stoichiometric coefficient: 1.0

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Adenosine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Adenosine

RAC-alpha serine/threonine-protein kinase
type: Protein
cellular location: Cell Membrane
entity reference: RAC-alpha serine/threonine-protein kinase

Protein/19460 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Transcription factor AP-1
stoichiometric coefficient: 1.0

Guanosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15996
xref: Reference/ChemSpider 6569
xref: Reference/KEGG Compound C00044
xref: Reference/PubChem-compound 6830
xref: Reference/HMDB HMDB0001273
xref: Reference/CAS 86-01-1
xref: Reference/BioCyc GTP
chemical formula: C10H16N5O14P3
molecular weight: 522.99066
structure: ChemicalStructure/PW C000986

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: Protein
cellular location: Cytosol
entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Guanosine triphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Guanosine triphosphate

Reference/UniProt A7YWD1
type: UnificationXref
id: A7YWD1
db: UniProt

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Compound/PW C000170 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Protein kinase C beta type
type: Protein
cellular location: Cytosol
entity reference: Protein kinase C beta type

Transport10000
type: Transport
participant stoichiometry: Compound/PW C000034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000034 Extracellular Space/Stoichiometry/1.0
right: Adenosine
spontaneous: false
left: Adenosine
name: Adenosine (→) Transport: Bos taurus, Extracellular Space to Bos taurus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport10001
type: Transport
participant stoichiometry: Protein/19514 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19514 Nucleus/Stoichiometry/1.0
right: NF-kappa-B inhibitor zeta
spontaneous: false
left: NF-kappa-B inhibitor zeta
name: Nuclear factor NF-kappa-B p105 subunit (→), Nuclear factor NF-kappa-B p100 subunit (→) Transport: Bos taurus, Cell, Cytosol to Bos taurus, Cell, Nucleus
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])([O-])=O

Ras-related protein Rap-1b
type: Protein
cellular location: Cell Membrane
entity reference: Ras-related protein Rap-1b

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Mitogen-activated protein kinase 13
type: ProteinReference
xref: Reference/UniProt Q3T0N5
organism: Bos taurus

Compound/PW C000936 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine diphosphate
stoichiometric coefficient: 1.0

Aurora kinase A
type: Protein
cellular location: Cytosol
entity reference: Aurora kinase A

PIP3(16:0/16:0)
type: SmallMolecule
cellular location: Cytosol
entity reference: PIP3(16:0/16:0)

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/BioCyc Phosphatidylinositols
type: UnificationXref
id: Phosphatidylinositols
db: BioCyc

Reference/PubChem-compound 53480223
type: UnificationXref
id: 53480223
db: PubChem-compound

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Adenosine
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine

ProteinComplex/10492 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein gamma-beta
stoichiometric coefficient: 1.0

Protein/19448 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Aurora kinase A
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/HMDB HMDB0010147
type: UnificationXref
id: HMDB0010147
db: HMDB

Reference/UniProt Q3T0N5
type: UnificationXref
id: Q3T0N5
db: UniProt

ChemicalStructure/PW C000936
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Transcription factor AP-1
type: ProteinReference
xref: Reference/UniProt O77627
organism: Bos taurus

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
type: ProteinReference
xref: Reference/UniProt Q3SZE7
organism: Bos taurus

Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
type: UnificationXref
id: GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
db: BioCyc

PIP3(16:0/16:0)
type: SmallMolecule
entity reference: PIP3(16:0/16:0)

Reference/GENE ONTOLOGY GO 0005634
type: UnificationXref
id: GO:0005634
db: GENE ONTOLOGY

Serine/threonine-protein kinase PAK 1
type: Protein
cellular location: Cytosol
entity reference: Serine/threonine-protein kinase PAK 1

PIP3(16:0/16:0)
type: SmallMoleculeReference
xref: Reference/BioCyc Phosphatidylinositols
xref: Reference/KEGG Compound C00626
xref: Reference/HMDB HMDB0010147
xref: Reference/ChemSpider 24768024
chemical formula: C41H82O22P4
molecular weight: 1050.4248
structure: ChemicalStructure/PW C006188

Reference/HMDB HMDB0010032
type: UnificationXref
id: HMDB0010032
db: HMDB

Compound/PW C006188 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: PIP3(16:0/16:0)
stoichiometric coefficient: 1.0

Reference/UniProt Q58DL7
type: UnificationXref
id: Q58DL7
db: UniProt

Dual specificity mitogen-activated protein kinase kinase 6
type: Complex
component stoichiometry: Protein/19407 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Dual specificity mitogen-activated protein kinase kinase 6

Reference/PubChem-compound 60961
type: UnificationXref
id: 60961
db: PubChem-compound

Reference/ChEBI CHEBI 17489
type: UnificationXref
id: CHEBI:17489
db: ChEBI

Reference/UniProt O77627
type: UnificationXref
id: O77627
db: UniProt

Cyclic AMP-responsive element-binding protein 1
type: Protein
cellular location: Cytosol
entity reference: Cyclic AMP-responsive element-binding protein 1

Reference/UniProt A7YY51
type: UnificationXref
id: A7YY51
db: UniProt

PIP2(16:0/16:0)
type: SmallMolecule
cellular location: Cell Membrane
entity reference: PIP2(16:0/16:0)

Reference/BioCyc CAMP
type: UnificationXref
id: CAMP
db: BioCyc

Inhibitor of nuclear factor kappa-B kinase subunit alpha
type: Protein
cellular location: Cytosol
entity reference: Inhibitor of nuclear factor kappa-B kinase subunit alpha

Reference/UniProt Q3T0M4
type: UnificationXref
id: Q3T0M4
db: UniProt

Protein/19358 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit beta
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q3MHF1
organism: Bos taurus

Reference/HMDB HMDB0001201
type: UnificationXref
id: HMDB0001201
db: HMDB

Protein/16922 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
stoichiometric coefficient: 1.0

Protein/19475 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Activating transcription factor 2
stoichiometric coefficient: 1.0

Apoptosis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway109198
pathway component: SubPathwayInteraction109198
name: SubPathway

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: O7P2
molecular weight: 173.91193
structure: ChemicalStructure/PW C000170

Regulation of glutamate and Dopamine release in the brain
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway109196
pathway component: SubPathwayInteraction109196
name: SubPathway

Protein/19433 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Rho guanine nucleotide exchange factor 9
stoichiometric coefficient: 1.0

Coronary Artery Vasodilation in the heart
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway109197
pathway component: SubPathwayInteraction109197
name: SubPathway

Activating transcription factor 2
type: ProteinReference
xref: Reference/UniProt F1N177
organism: Bos taurus

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: Reference/UniProt P24256
organism: Bos taurus

Par-6 family cell polarity regulator alpha
type: ProteinReference
xref: Reference/UniProt F6RHP0
organism: Bos taurus

Reference/UniProt Q6TJY3
type: UnificationXref
id: Q6TJY3
db: UniProt

Guanine nucleotide-binding protein G(T) subunit gamma-T1
type: Protein
cellular location: Cytosol
entity reference: Guanine nucleotide-binding protein G(T) subunit gamma-T1

cAMP-dependent protein kinase catalytic subunit beta
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit beta

ReactionCatalysis164446
type: Catalysis
controller: Inhibitor of nuclear factor kappa-B kinase subunit beta
controlled: 2.7.11.10
control type: ACTIVATION

Reference/ChEBI CHEBI 15996
type: UnificationXref
id: CHEBI:15996
db: ChEBI

ReactionCatalysis164442
type: Catalysis
controller: cAMP-dependent protein kinase catalytic subunit beta
controlled: 2.7.11.1
control type: ACTIVATION

ReactionCatalysis164445
type: Catalysis
controller: Inhibitor of nuclear factor kappa-B kinase subunit alpha
controlled: 2.7.11.10
control type: ACTIVATION

ReactionCatalysis164444
type: Catalysis
controller: RAC-alpha serine/threonine-protein kinase
controlled: 2.7.11.1
control type: ACTIVATION

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

ReactionCatalysis164441
type: Catalysis
controller: Ribosomal protein S6 kinase beta-1
controlled: 2.7.11.1
control type: ACTIVATION

Protein/7764 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 1.0

ReactionCatalysis164440
type: Catalysis
controller: Cell division control protein 42 homolog
controlled: 2.7.11.13
control type: ACTIVATION

Protein/19509 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inhibitor of nuclear factor kappa-B kinase subunit beta
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Protein kinase C beta type
type: ProteinReference
xref: Reference/UniProt A5D7N0
organism: Bos taurus

Reference/CAS 60-92-4
type: UnificationXref
id: 60-92-4
db: CAS

Compound/PW C006188/Stoichiometry/1.0
type: Stoichiometry
physical entity: PIP3(16:0/16:0)
stoichiometric coefficient: 1.0

Ribosomal protein S6 kinase beta-1
type: ProteinReference
xref: Reference/UniProt Q6TJY3
organism: Bos taurus

Protein/19458 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mitogen-activated protein kinase 13
stoichiometric coefficient: 1.0

ReactionCatalysis164439
type: Catalysis
controller: Par-6 family cell polarity regulator alpha
controlled: 2.7.11.13
control type: ACTIVATION

Reaction174175
type: BiochemicalReaction
participant stoichiometry: Protein/19409 Cytosol/Stoichiometry/1.0
right: RAF proto-oncogene serine/threonine-protein kinase
spontaneous: false
left: RAF proto-oncogene serine/threonine-protein kinase
name: Serine/threonine-protein kinase B-raf → Serine/threonine-protein kinase B-raf
conversion direction: LEFT_TO_RIGHT

Guanosine diphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Guanosine diphosphate

ReactionCatalysis164436
type: Catalysis
controller: Dual specificity mitogen-activated protein kinase kinase 6
controlled: 2.7.12.2
control type: ACTIVATION

2.7.12.2
type: BiochemicalReaction
participant stoichiometry: Protein/19413 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: Mitogen-activated protein kinase 1
spontaneous: false
EC number: 2.7.12.2
left: Mitogen-activated protein kinase 1
name: Mitogen-activated protein kinase 1 → Mitogen-activated protein kinase 1 + Phosphate
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis164435
type: Catalysis
controller: Cell division control protein 42 homolog
controlled: 2.7.11.1
control type: ACTIVATION

ReactionCatalysis164438
type: Catalysis
controller: Protein kinase C beta type
controlled: 2.7.11.13
control type: ACTIVATION

2.7.11.24
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001104 Nucleus/Stoichiometry/1.0
participant stoichiometry: Protein/19422 Nucleus/Stoichiometry/1.0
right: Phosphate
right: ETS translocation variant 1
spontaneous: false
EC number: 2.7.11.24
left: ETS translocation variant 1
name: ETS domain-containing protein Elk-1 → ETS domain-containing protein Elk-1 + Phosphate
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis164437
type: Catalysis
controller: Mitogen-activated protein kinase 13
controlled: 2.7.11.24
control type: ACTIVATION

2.7.11.11
type: BiochemicalReaction
participant stoichiometry: Protein/19358 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000041 Cytosol/Stoichiometry/1.0
right: cAMP-dependent protein kinase catalytic subunit beta
right: cAMP
spontaneous: false
EC number: 2.7.11.11
left: cAMP
name: cAMP → cAMP + cAMP-dependent protein kinase catalytic subunit beta
conversion direction: LEFT_TO_RIGHT

Reaction174179
type: BiochemicalReaction
participant stoichiometry: Protein/19396 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000041 Cytosol/Stoichiometry/1.0
right: Rap guanine nucleotide exchange factor 2
spontaneous: true
left: Rap guanine nucleotide exchange factor 2
left: cAMP
name: Rap guanine nucleotide exchange factor 2 + cAMP → Rap guanine nucleotide exchange factor 2 with cAMP
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis164432
type: Catalysis
controller: Mitogen-activated protein kinase 13
controlled: 2.7.11.24
control type: ACTIVATION

ReactionCatalysis164434
type: Catalysis
controller: Serine/threonine-protein kinase PAK 1
controlled: 2.7.11.1
control type: ACTIVATION

Compound/PW C006188 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: PIP3(16:0/16:0)
stoichiometric coefficient: 1.0

Reference/UniProt A5D7N0
type: UnificationXref
id: A5D7N0
db: UniProt

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

ReactionCatalysis164430
type: Catalysis
controller: Dual specificity mitogen-activated protein kinase kinase 6
controlled: 2.7.12.2
control type: ACTIVATION

Reaction174172
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/10492 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19391 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/7764 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000986 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000936 Cytosol/Stoichiometry/1.0
right: Guanosine diphosphate
right: Guanine nucleotide-binding protein gamma-beta
right: Unknown
right: Adenosine receptor A2b
spontaneous: false
left: Adenosine receptor A2b
left: Guanosine triphosphate
name: Adenosine receptor A2a + Guanosine triphosphate → Adenosine receptor A2a + Guanine nucleotide-binding protein alpha + Guanine nucleotide-binding protein gamma-beta + Guanosine diphosphate
conversion direction: LEFT_TO_RIGHT

Protein/19396 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Rap guanine nucleotide exchange factor 2
stoichiometric coefficient: 1.0

Reaction174173
type: BiochemicalReaction
participant stoichiometry: Protein/19400 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19396 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000986 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000936 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000041 Cytosol/Stoichiometry/1.0
right: Guanosine diphosphate
right: Ras-related protein Rap-1A
spontaneous: false
left: Rap guanine nucleotide exchange factor 2
left: Ras-related protein Rap-1A
left: cAMP
left: Guanosine triphosphate
name: Guanosine triphosphate + Rap guanine nucleotide exchange factor 3 + Ras-related protein Rap-1A + cAMP → Guanosine diphosphate + Ras-related protein Rap-1A
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00035
type: UnificationXref
id: C00035
db: KEGG Compound

Reaction174174
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19407 Cytosol/Stoichiometry/1.0
right: Phosphate
right: Dual specificity mitogen-activated protein kinase kinase 6
spontaneous: false
left: Dual specificity mitogen-activated protein kinase kinase 6
name: Dual specificity mitogen-activated protein kinase kinase 2 → Dual specificity mitogen-activated protein kinase kinase 2 + Phosphate
conversion direction: LEFT_TO_RIGHT

Reference/UniProt Q1LZD0
type: UnificationXref
id: Q1LZD0
db: UniProt

Inhibitor of nuclear factor kappa-B kinase subunit alpha
type: Protein
cellular location: Cell Membrane
entity reference: Inhibitor of nuclear factor kappa-B kinase subunit alpha

Reference/UniProt A2VE60
type: UnificationXref
id: A2VE60
db: UniProt

2.7.11.11
type: BiochemicalReaction
participant stoichiometry: Protein/19379 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: Cyclic AMP-responsive element-binding protein 1
spontaneous: false
EC number: 2.7.11.11
left: Cyclic AMP-responsive element-binding protein 1
name: Cyclic AMP-responsive element-binding protein 1 → Cyclic AMP-responsive element-binding protein 1 + Phosphate
conversion direction: LEFT_TO_RIGHT

Mitogen-activated protein kinase 1
type: ProteinReference
xref: Reference/UniProt A2VE60
organism: Bos taurus

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ETS translocation variant 1
type: Protein
cellular location: Nucleus
entity reference: ETS translocation variant 1

ReactionCatalysis164428
type: Catalysis
controller: Aurora kinase A
controlled: 2.7.11.25
control type: ACTIVATION

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])(=O)OP([O-])([O-])=O

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

ReactionCatalysis164425
type: Catalysis
controller: Rho guanine nucleotide exchange factor 9
controlled: Reaction174184
control type: ACTIVATION

Transcription factor AP-1
type: Protein
cellular location: Nucleus
entity reference: Transcription factor AP-1

ReactionCatalysis164424
type: Catalysis
controller: cAMP-dependent protein kinase catalytic subunit beta
controlled: 2.7.11.11
control type: ACTIVATION

ReactionCatalysis164427
type: Catalysis
controller: Cell division control protein 42 homolog
controlled: 2.7.11.25
control type: ACTIVATION

Reference/UniProt Q3MHF1
type: UnificationXref
id: Q3MHF1
db: UniProt

ReactionCatalysis164426
type: Catalysis
controller: Serine/threonine-protein kinase PAK 1
controlled: 2.7.11.25
control type: ACTIVATION

ReactionCatalysis164420
type: Catalysis
controller: Rap guanine nucleotide exchange factor 2
controlled: Reaction174180
control type: ACTIVATION

ReactionCatalysis164423
type: Catalysis
controller: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
controlled: Reaction174182
control type: ACTIVATION

Phosphate
type: SmallMolecule
cellular location: Nucleus
entity reference: Phosphate

ReactionCatalysis164422
type: Catalysis
controller: Ras-related protein Rap-1b
controlled: Reaction174182
control type: ACTIVATION

Reference/KEGG Compound C00044
type: UnificationXref
id: C00044
db: KEGG Compound

Reference/ChemSpider 24768024
type: UnificationXref
id: 24768024
db: ChemSpider

Ras-related protein Rap-1A
type: Protein
cellular location: Cytosol
entity reference: Ras-related protein Rap-1A

BCL2 associated agonist of cell death
type: Protein
cellular location: Cytosol
entity reference: BCL2 associated agonist of cell death
name: SubPathwayInput

Bos taurus
type: BioSource
xref: Reference/TAXONOMY 9913

ETS translocation variant 1
type: ProteinReference
xref: Reference/UniProt Q2KIC2
organism: Bos taurus

Reference/UniProt A4IFG1
type: UnificationXref
id: A4IFG1
db: UniProt

ReactionCatalysis164417
type: Catalysis
controller: Dual specificity mitogen-activated protein kinase kinase 6
controlled: 2.7.12.2
control type: ACTIVATION

ReactionCatalysis164419
type: Catalysis
controller: Mitogen-activated protein kinase 1
controlled: 2.7.11.24
control type: ACTIVATION

Compound/PW C000986 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine triphosphate
stoichiometric coefficient: 1.0

ReactionCatalysis164414
type: Catalysis
controller: Rap guanine nucleotide exchange factor 2
controlled: Reaction174173
control type: ACTIVATION

Reaction174197
type: BiochemicalReaction
participant stoichiometry: Protein/19479 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19485 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19438 Cytosol/Stoichiometry/1.0
right: Cell division control protein 42 homolog
right: Par-6 family cell polarity regulator alpha
right: Protein kinase C beta type
spontaneous: false
left: Cell division control protein 42 homolog
left: Par-6 family cell polarity regulator alpha
left: Protein kinase C beta type
name: Cell division control protein 42 homolog with GTP + Partitioning defective 6 homolog alpha + Protein kinase C zeta type → Cell division control protein 42 homolog with GTP + Partitioning defective 6 homolog alpha + Protein kinase C zeta type
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis164413
type: Catalysis
controller: Guanine nucleotide-binding protein alpha-beta-gamma
controlled: Reaction174172
control type: ACTIVATION

2.7.11.13
type: BiochemicalReaction
participant stoichiometry: Protein/19489 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: Ribosomal protein S6 kinase beta-1
spontaneous: false
EC number: 2.7.11.13
left: Ribosomal protein S6 kinase beta-1
name: Ribosomal protein S6 kinase alpha-1 → Phosphate + Ribosomal protein S6 kinase alpha-1
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis164416
type: Catalysis
controller: RAF proto-oncogene serine/threonine-protein kinase
controlled: Reaction174174
control type: ACTIVATION

2.7.11.1
type: BiochemicalReaction
participant stoichiometry: Protein/19493 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: BCL2 associated agonist of cell death
spontaneous: false
EC number: 2.7.11.1
left: BCL2 associated agonist of cell death
name: Bcl2-associated agonist of cell death → Bcl2-associated agonist of cell death + Phosphate
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

ReactionCatalysis164415
type: Catalysis
controller: Ras-related protein Rap-1A
controlled: Reaction174174
control type: ACTIVATION

Mitogen-activated protein kinase 13
type: Protein
cellular location: Cytosol
entity reference: Mitogen-activated protein kinase 13

2.7.11.24
type: BiochemicalReaction
participant stoichiometry: Protein/19460 Nucleus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Nucleus/Stoichiometry/1.0
right: Transcription factor AP-1
right: Phosphate
spontaneous: false
EC number: 2.7.11.24
left: Transcription factor AP-1
name: Transcription factor AP-1 → Phosphate + Transcription factor AP-1
conversion direction: LEFT_TO_RIGHT

Reaction174192
type: BiochemicalReaction
participant stoichiometry: Protein/19443 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19438 Cytosol/Stoichiometry/1.0
right: Cell division control protein 42 homolog
right: Serine/threonine-protein kinase PAK 1
spontaneous: false
left: Cell division control protein 42 homolog
left: Serine/threonine-protein kinase PAK 1
name: Cell division control protein 42 homolog with GTP + Serine/threonine-protein kinase PAK 1 → Cell division control protein 42 homolog with GTP + Serine/threonine-protein kinase PAK 1
conversion direction: LEFT_TO_RIGHT

2.7.11.1
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/11209 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: Dual specificity mitogen-activated protein kinase kinase 6
spontaneous: false
EC number: 2.7.11.1
left: Dual specificity mitogen-activated protein kinase kinase 6
name: Dual specificity mitogen-activated protein kinase kinase 6 → Dual specificity mitogen-activated protein kinase kinase 6 + Phosphate
conversion direction: LEFT_TO_RIGHT

2.7.12.2
type: BiochemicalReaction
participant stoichiometry: Protein/19458 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: Mitogen-activated protein kinase 13
spontaneous: false
EC number: 2.7.12.2
left: Mitogen-activated protein kinase 13
name: Mitogen-activated protein kinase 11 → Mitogen-activated protein kinase 11 + Phosphate
conversion direction: LEFT_TO_RIGHT

2.7.11.24
type: BiochemicalReaction
participant stoichiometry: Protein/19475 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Activating transcription factor 2
right: Phosphate
spontaneous: false
EC number: 2.7.11.24
left: Activating transcription factor 2
name: Cyclic AMP-dependent transcription factor ATF-2 → Cyclic AMP-dependent transcription factor ATF-2 + Phosphate
conversion direction: LEFT_TO_RIGHT

Ras-related protein Rap-1b
type: ProteinReference
xref: Reference/UniProt Q3T0M4
organism: Bos taurus

Rho guanine nucleotide exchange factor 9
type: ProteinReference
xref: Reference/UniProt Q58DL7
organism: Bos taurus

ChemicalStructure/PW C000034
type: ChemicalStructure
structure format: SMILES

PIP2(16:0/16:0)
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0010032
xref: Reference/BioCyc Phosphatidylinositols
xref: Reference/PubChem-compound 53480223
xref: Reference/KEGG Compound C00626
xref: Reference/ChemSpider 24767909
chemical formula: C41H81O19P3
molecular weight: 970.4585
structure: ChemicalStructure/PW C006073

Cell division control protein 42 homolog
type: ProteinReference
xref: Reference/UniProt Q2KJ93
organism: Bos taurus

2.7.11.25
type: BiochemicalReaction
participant stoichiometry: Protein/19448 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: Aurora kinase A
spontaneous: false
EC number: 2.7.11.25
left: Aurora kinase A
name: Mitogen-activated protein kinase kinase kinase 1 → Mitogen-activated protein kinase kinase kinase 1 + Phosphate
conversion direction: LEFT_TO_RIGHT

2.7.11.25
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19407 Cytosol/Stoichiometry/1.0
right: Phosphate
right: Dual specificity mitogen-activated protein kinase kinase 6
spontaneous: false
EC number: 2.7.11.25
left: Dual specificity mitogen-activated protein kinase kinase 6
name: Dual specificity mitogen-activated protein kinase kinase 7 → Dual specificity mitogen-activated protein kinase kinase 7 + Phosphate
conversion direction: LEFT_TO_RIGHT

Reference/PathWhiz PW109216
type: UnificationXref
id: PW109216
db: PathWhiz

Protein/19400 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ras-related protein Rap-1A
stoichiometric coefficient: 1.0

Rho guanine nucleotide exchange factor 9
type: Protein
cellular location: Cell Membrane
entity reference: Rho guanine nucleotide exchange factor 9

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
type: Protein
cellular location: Cytosol
entity reference: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

2.7.12.2
type: BiochemicalReaction
participant stoichiometry: Protein/19458 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: Mitogen-activated protein kinase 13
spontaneous: false
EC number: 2.7.12.2
left: Mitogen-activated protein kinase 13
name: Mitogen-activated protein kinase 8 → Mitogen-activated protein kinase 8 + Phosphate
conversion direction: LEFT_TO_RIGHT

Guanine nucleotide-binding protein alpha-beta-gamma
type: Complex
component stoichiometry: Protein/19341 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/19753 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/19350 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Guanine nucleotide-binding protein G(T) subunit gamma-T1
component: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
component: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Protein/19443 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Serine/threonine-protein kinase PAK 1
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00626
type: UnificationXref
id: C00626
db: KEGG Compound

Reaction174180
type: BiochemicalReaction
participant stoichiometry: Protein/19430 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000936 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000986 Cell Membrane/Stoichiometry/1.0
right: Guanosine diphosphate
right: Ras-related protein Rap-1b
spontaneous: false
left: Guanosine triphosphate
left: Ras-related protein Rap-1b
name: GTPase HRas with GDP + Guanosine triphosphate → GTPase HRas with GTP + Guanosine diphosphate
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 8977
type: UnificationXref
id: 8977
db: PubChem-compound

Reaction174181
type: BiochemicalReaction
participant stoichiometry: Protein/16922 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Protein/19430 Cell Membrane/Stoichiometry/1.0
right: Ras-related protein Rap-1b
right: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
spontaneous: false
left: Ras-related protein Rap-1b
left: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
name: GTPase HRas with GTP + Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform → GTPase HRas with GTP + Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
conversion direction: LEFT_TO_RIGHT

Reaction174182
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006188 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006073 Cell Membrane/Stoichiometry/1.0
right: PIP3(16:0/16:0)
spontaneous: false
left: PIP2(16:0/16:0)
name: PIP2(16:0/16:0) → PIP3(16:0/16:0)
conversion direction: LEFT_TO_RIGHT

Reference/CAS 58-61-7
type: UnificationXref
id: 58-61-7
db: CAS

2.7.11.11
type: BiochemicalReaction
participant stoichiometry: Protein/19433 Cell Membrane/Stoichiometry/1.0
right: Rho guanine nucleotide exchange factor 9
spontaneous: false
EC number: 2.7.11.11
left: Rho guanine nucleotide exchange factor 9
name: Rho guanine nucleotide exchange factor 7 → Rho guanine nucleotide exchange factor 7 with phosphate
conversion direction: LEFT_TO_RIGHT

Reaction174184
type: BiochemicalReaction
participant stoichiometry: Protein/19438 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000986 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000936 Cytosol/Stoichiometry/1.0
right: Cell division control protein 42 homolog
right: Guanosine diphosphate
spontaneous: false
left: Cell division control protein 42 homolog
left: Guanosine triphosphate
name: Cell division control protein 42 homolog with GDP + Guanosine triphosphate → Cell division control protein 42 homolog with GTP + Guanosine diphosphate
conversion direction: LEFT_TO_RIGHT

Reference/UniProt Q2KJ93
type: UnificationXref
id: Q2KJ93
db: UniProt

Reaction174185
type: BiochemicalReaction
participant stoichiometry: Protein/19443 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19438 Cytosol/Stoichiometry/1.0
right: Cell division control protein 42 homolog
right: Serine/threonine-protein kinase PAK 1
spontaneous: true
left: Cell division control protein 42 homolog
left: Serine/threonine-protein kinase PAK 1
name: Cell division control protein 42 homolog with GTP + Mitogen-activated protein kinase kinase kinase 4 → Cell division control protein 42 homolog with GTP + Mitogen-activated protein kinase kinase kinase 4
conversion direction: LEFT_TO_RIGHT

Activating transcription factor 2
type: Protein
cellular location: Cytosol
entity reference: Activating transcription factor 2

Protein/19479 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Par-6 family cell polarity regulator alpha
stoichiometric coefficient: 1.0

Reference/UniProt Q3SZE7
type: UnificationXref
id: Q3SZE7
db: UniProt

NF-kappa-B inhibitor zeta
type: Protein
cellular location: Cytosol
entity reference: NF-kappa-B inhibitor zeta

ChemicalStructure/PW C000041
type: ChemicalStructure
structure format: SMILES

Serine/threonine-protein kinase PAK 1
type: ProteinReference
xref: Reference/UniProt Q08E52
organism: Bos taurus

Reference/UniProt F1MSG6
type: UnificationXref
id: F1MSG6
db: UniProt

Aurora kinase A
type: ProteinReference
xref: Reference/UniProt Q2TA06
organism: Bos taurus

Protein/19341 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
stoichiometric coefficient: 1.0

Reference/UniProt A7Z059
type: UnificationXref
id: A7Z059
db: UniProt

Mitogen-activated protein kinase 1
type: Protein
cellular location: Nucleus
entity reference: Mitogen-activated protein kinase 1

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: Protein
cellular location: Cell Membrane
entity reference: Inhibitor of nuclear factor kappa-B kinase subunit beta

Reference/ChEBI CHEBI 16335
type: UnificationXref
id: CHEBI:16335
db: ChEBI

Protein/19413 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mitogen-activated protein kinase 1
stoichiometric coefficient: 1.0

Adenosine receptor A2b
type: Protein
entity reference: Adenosine receptor A2b

NF-kappa-B inhibitor zeta
type: Protein
cellular location: Nucleus
entity reference: NF-kappa-B inhibitor zeta

Reference/ChemSpider 8630
type: UnificationXref
id: 8630
db: ChemSpider

Reference/SMPDB SMP0108174
type: UnificationXref
id: SMP0108174
db: SMPDB

Protein/19409 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: RAF proto-oncogene serine/threonine-protein kinase
stoichiometric coefficient: 1.0

Reference/UniProt F1MUT9
type: UnificationXref
id: F1MUT9
db: UniProt

Reference/HMDB HMDB0000058
type: UnificationXref
id: HMDB0000058
db: HMDB

Reference/UniProt P02698
type: UnificationXref
id: P02698
db: UniProt

Reference/HMDB HMDB0000050
type: UnificationXref
id: HMDB0000050
db: HMDB

ChemicalStructure/PW C006073
type: ChemicalStructure
structure format: SMILES

Adenosine receptor A2b
type: Protein
cellular location: Cytosol
entity reference: Adenosine receptor A2b

Reference/BioCyc ADENOSINE
type: UnificationXref
id: ADENOSINE
db: BioCyc

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: Reference/UniProt Q95KV0
organism: Bos taurus

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/ChemSpider 6569
type: UnificationXref
id: 6569
db: ChemSpider

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 17552
type: UnificationXref
id: CHEBI:17552
db: ChEBI

Reference/BioCyc GTP
type: UnificationXref
id: GTP
db: BioCyc

Compound/PW C000034 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine
stoichiometric coefficient: 1.0

Phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphate

Cell division control protein 42 homolog
type: Protein
cellular location: Cytosol
entity reference: Cell division control protein 42 homolog

Protein/19407 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Dual specificity mitogen-activated protein kinase kinase 6
stoichiometric coefficient: 2.0

Dual specificity mitogen-activated protein kinase kinase 6
type: Protein
cellular location: Cytosol
entity reference: Dual specificity mitogen-activated protein kinase kinase 6

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: Reference/UniProt Q5ER96
organism: Bos taurus

Inhibitor of nuclear factor kappa-B kinase subunit alpha
type: ProteinReference
xref: Reference/UniProt A7YWD1
organism: Bos taurus

Compound/PW C006073 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: PIP2(16:0/16:0)
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001273
type: UnificationXref
id: HMDB0001273
db: HMDB

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Rap guanine nucleotide exchange factor 2
type: Protein
cellular location: Cytosol
entity reference: Rap guanine nucleotide exchange factor 2

ReactionCatalysis136704
type: Catalysis
controller: Unknown
controlled: 4.6.1.1
control type: ACTIVATION

Reference/UniProt F6RHP0
type: UnificationXref
id: F6RHP0
db: UniProt

ChemicalStructure/PW C000986
type: ChemicalStructure
structure format: SMILES

Rap guanine nucleotide exchange factor 2
type: Protein
cellular location: Cell Membrane
entity reference: Rap guanine nucleotide exchange factor 2

Compound/PW C000986 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine triphosphate
stoichiometric coefficient: 1.0

ReactionCatalysis164170
type: Catalysis
controller: cAMP-dependent protein kinase catalytic subunit beta
controlled: 2.7.11.11
control type: ACTIVATION

Reference/UniProt Q5E9X2
type: UnificationXref
id: Q5E9X2
db: UniProt

ReactionCatalysis164173
type: Catalysis
controller: cAMP-dependent protein kinase catalytic subunit beta
controlled: 2.7.11.11
control type: ACTIVATION

ReactionCatalysis136703
type: Catalysis
controller: Unknown
controlled: 4.6.1.1
control type: ACTIVATION

Reference/UniProt Q5ER96
type: UnificationXref
id: Q5ER96
db: UniProt

Protein/19514 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: NF-kappa-B inhibitor zeta
stoichiometric coefficient: 1.0

Reference/ChemSpider 54923
type: UnificationXref
id: 54923
db: ChemSpider

Guanine nucleotide-binding protein G(T) subunit gamma-T1
type: ProteinReference
xref: Reference/UniProt P02698
organism: Bos taurus

Protein/19422 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: ETS translocation variant 1
stoichiometric coefficient: 1.0

NF-kappa-B inhibitor zeta
type: ProteinReference
xref: Reference/UniProt A7Z059
organism: Bos taurus

Protein/19753 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein G(T) subunit gamma-T1
stoichiometric coefficient: 1.0

Reference/CAS 86-01-1
type: UnificationXref
id: 86-01-1
db: CAS

Nucleus
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005634

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: Reference/UniProt P32871
organism: Bos taurus

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
xref: Reference/UniProt A7YY51
organism: Bos taurus

Reference/PubChem-compound 6076
type: UnificationXref
id: 6076
db: PubChem-compound

Compound/PW C001104 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/UniProt Q2TA06
type: UnificationXref
id: Q2TA06
db: UniProt

Reference/UniProt P24256
type: UnificationXref
id: P24256
db: UniProt

Protein/19503 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inhibitor of nuclear factor kappa-B kinase subunit alpha
stoichiometric coefficient: 1.0

Unknown
type: ProteinReference
organism: Bos taurus

Compound/PW C001104 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase catalytic subunit beta
type: Protein
entity reference: cAMP-dependent protein kinase catalytic subunit beta

4.6.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000041 Cytosol/Stoichiometry/1.0
right: Pyrophosphate
right: cAMP
spontaneous: false
EC number: 4.6.1.1
left: Adenosine triphosphate
name: Adenosine triphosphate → Pyrophosphate + cAMP
conversion direction: LEFT_TO_RIGHT

Compound/PW C000936 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine diphosphate
stoichiometric coefficient: 1.0

Reference/CAS 146-91-8
type: UnificationXref
id: 146-91-8
db: CAS

Ras-related protein Rap-1A
type: ProteinReference
xref: Reference/UniProt A4IFG1
organism: Bos taurus

Reference/UniProt Q08E52
type: UnificationXref
id: Q08E52
db: UniProt

Ribosomal protein S6 kinase beta-1
type: Protein
cellular location: Cytosol
entity reference: Ribosomal protein S6 kinase beta-1

ChemicalStructure/PW C006188
type: ChemicalStructure
structure format: SMILES

Protein/19407 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dual specificity mitogen-activated protein kinase kinase 6
stoichiometric coefficient: 1.0

Dual specificity mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: Reference/UniProt Q5E9X2
organism: Bos taurus